2,124 results on '"Marietta, M."'
Search Results
2. Th17/1 and ex-Th17 cells are detected in patients with polyarticular juvenile arthritis and increase following treatment
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Stephanie Wood, Justin Branch, Priscilla Vasquez, Marietta M. DeGuzman, Amanda Brown, Anna Carmela Sagcal-Gironella, Saimun Singla, Andrea Ramirez, and Tiphanie P. Vogel
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IL-6 ,STAT3 ,Th17 ,Treg ,Th17/1 ,Ex-Th17 ,Pediatrics ,RJ1-570 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background A better understanding of the pathogenesis of polyarticular juvenile idiopathic arthritis (polyJIA) is needed to aide in the development of data-driven approaches to guide selection between therapeutic options. One inflammatory pathway of interest is JAK-STAT signaling. STAT3 is a transcription factor critical to the differentiation of inflammatory T helper 17 cells (Th17s). Previous studies have demonstrated increased STAT3 activation in adult patients with rheumatoid arthritis, but less is known about STAT3 activation in polyJIA. We hypothesized that Th17 cells and STAT3 activation would be increased in treatment-naïve polyJIA patients compared to pediatric controls. Methods Blood from 17 patients with polyJIA was collected at initial diagnosis and again if remission was achieved (post-treatment). Pediatric healthy controls were also collected. Peripheral blood mononuclear cells were isolated and CD4 + T cell subsets and STAT activation (phosphorylation) were evaluated using flow cytometry. Data were analyzed using Mann–Whitney U and Wilcoxon matched-pairs signed rank tests. Results Treatment-naïve polyJIA patients had increased Th17 cells (CD3 + CD4 + interleukin(IL)-17 +) compared to controls (0.15% v 0.44%, p
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- 2024
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3. Hospital energy demand forecasting for prioritisation during periods of constrained supply
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Megashnee Munsamy, Arnesh Telukdarie, Takeru Igusa, and Marietta M Squire
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energy, healthcare, hospital, business ,Industrial engineering. Management engineering ,T55.4-60.8 ,Social Sciences ,Commerce ,HF1-6182 ,Business ,HF5001-6182 - Abstract
Purpose: Sustaining healthcare operations without adequate energy capacity creates significant challenges, especially during periods of constrained energy supply. This research develops a clinical and non-clinical activity-based hospital energy model for electrical load prioritization during periods of constrained energy supply. Design/methodology/approach: Discrete event modelling is adopted for development of the hospital energy model (HEM). The basis of the HEM is business process mapping of the hospitals clinical and non-clinical activities. The model prioritizes the electrical load demand as Priority 1, 2 and 3; with Priority 1 activities essential to the survival of patients, Priority 2 activities are critical activities that are required after one to four hours, and Priority 3 activities can run for several hours without electricity. Findings: The model was applied to a small, medium, and large hospital. The results demonstrate that Priority 2 activities have the highest energy demand, followed by Priority 1 and Priority 3 activities, respectively for all hospital sizes. For the medium and large hospitals, the top three contributors to energy demand are lighting, HVAC, and patient services. For the small hospital, it is patient services, lighting, and HVAC, respectively. Research limitations/implications: The model is specific to hospitals but can be modified for other healthcare facilities. Practical implications: The resolution of the electrical energy demand down to the business activity level, enables hospitals to evaluate current practices for optimization. It facilitates multiple energy supply scenarios, enabling hospital management to conduct feasibility studies based on available power supply options Social implications: Improved planning of capital expenditure and operational budgets and during constrained energy supply. This reduces risk to hospitals and ensures consistent quality of service. Originality/value: Current hospital energy models are limited, especially for operations management under constrained energy supply. A simple to use model is proposed to assist in planning of activities based on available supply.
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- 2023
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4. Identification of eight novel proteasome variants in five unrelated cases of proteasome-associated autoinflammatory syndromes (PRAAS)
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Jonas Johannes Papendorf, Frédéric Ebstein, Sara Alehashemi, Daniela Gerent Petry Piotto, Anna Kozlova, Maria Teresa Terreri, Anna Shcherbina, Andre Rastegar, Marta Rodrigues, Renan Pereira, Sophia Park, Bin Lin, Kat Uss, Sophie Möller, Ana Flávia da Silva Pina, Flavio Sztajnbok, Sofia Torreggiani, Julie Niemela, Jennifer Stoddard, Sergio D. Rosenzweig, Andrew J. Oler, Colton McNinch, Marietta M. de Guzman, Adriana Fonseca, Nicole Micheloni, Melissa Mariti Fraga, Sandro Félix Perazzio, Raphaela Goldbach-Mansky, Adriana A. de Jesus, and Elke Krüger
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proteasomopathy ,proteasome associated autoinflammatory syndrome ,type I interferon ,interferonopathy ,PSMB8 ,PSMB10 ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Mutations in genes coding for proteasome subunits and/or proteasome assembly helpers typically cause recurring autoinflammation referred to as chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperatures (CANDLE) or proteasome-associated autoinflammatory syndrome (PRAAS). Patients with CANDLE/PRAAS present with mostly chronically elevated type I interferon scores that emerge as a consequence of increased proteotoxic stress by mechanisms that are not fully understood. Here, we report on five unrelated patients with CANDLE/PRAAS carrying novel inherited proteasome missense and/or nonsense variants. Four patients were compound heterozygous for novel pathogenic variants in the known CANDLE/PRAAS associated genes, PSMB8 and PSMB10, whereas one patient showed additive loss-of-function mutations in PSMB8. Variants in two previously not associated proteasome genes, PSMA5 and PSMC5, were found in a patient who also carried the PSMB8 founder mutation, p.T75M. All newly identified mutations substantially impact the steady-state expression of the affected proteasome subunits and/or their incorporation into mature 26S proteasomes. Our observations expand the spectrum of PRAAS-associated genetic variants and improve a molecular diagnosis and genetic counseling of patients with sterile autoinflammation.
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- 2023
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5. Regulation of Mitochondrial Homeostasis and Metabolic Programming in Memory B cells by Mitophagy
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Marietta M. Budai, Min Li, Srikanth Kodali, Min Chen, and Jin Wang
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Cytology ,QH573-671 - Abstract
The formation of long-lived immune memory cells specific for pathogens is critical for the establishment of long-term immune protection against future infections. BNIP3L/NIX and BNIP3, two functionally redundant BCL2 family members required for mitophagy, undergo significant upregulation after memory B cells are formed. Deletion of Bnip3l and Bnip3 leads to mitochondrial accumulation, and increases in oxidative phosphorylation and fatty acid synthesis, resulting in the loss of memory B cells. These observations suggest that after the formation of memory B cells, mitophagy is critical for clearing superfluous mitochondria to re-shape the metabolic programs, thereby protecting the metabolic quiescence and longevity of memory B cells .
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- 2022
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6. Targeting HIV-1 reservoirs in T cell subsets
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Min Li, Marietta M. Budai, Min Chen, and Jin Wang
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HIV-1 ,cell death ,anti-apoptotic molecules ,autophagy ,latency reversal agents ,T cell subsets ,Immunologic diseases. Allergy ,RC581-607 - Abstract
The HIV-1 reservoirs harbor the latent proviruses that are integrated into the host genome. It is a challenging task to eradicate the proviruses in order to achieve an HIV cure. We have described a strategy for the clearance of HIV-1 infection through selective elimination of host cells harboring replication-competent HIV (SECH), by inhibition of autophagy and promotion of apoptosis during viral re-activation. HIV-1 can infect various CD4+ T cell subsets, but it is not known whether the SECH approach is equally effective in targeting HIV-1 reservoirs in these different subsets in vivo. In a humanized mouse model, we found that treatments of HIV-1 infection by suppressive antiretroviral therapy (ART) led to the establishment of latent HIV reservoirs in naïve, central memory and effector memory T cells. Moreover, SECH treatments could clear latent HIV-1 reservoirs in these different T cell subsets of humanized mice. Co-culture studies showed that T cell subsets latently infected by HIV-1, but not uninfected bystander cells, were susceptible to cell death induced by SECH treatments. Our study suggests that the SECH strategy is effective for specific targeting of latent HIV-1 reservoirs in different T cell subsets.
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- 2023
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7. Particle yields from numerical simulations
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Homor, Marietta M. and Jakovác, Antal
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High Energy Physics - Phenomenology ,Condensed Matter - Statistical Mechanics ,High Energy Physics - Lattice - Abstract
In this paper we use numerical simulations to calculate the particle yields. We demonstrate that in the model of local particle creation the deviation from the pure exponential distribution is natural even in equilibrium, and an approximate Tsallis-Pareto-like distribution function can be well fitted to the calculated yields, in accordance with the experimental observations. We present numerical simulations in classical $\Phi^4$ model as well as in the SU(3) quantum Yang-Mills theory to clarify this issue., Comment: 8 pages, 12 figures
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- 2017
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8. The Utility of Self-Determination Theory in Predicting Transition Readiness in Adolescents With Special Healthcare Needs
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Stephens, Sara B., Raphael, Jean L., Zimmerman, Cortney T., Garland, Beth H., de Guzman, Marietta M., Walsh, Seema M., Hergenroeder, Albert C., and Wiemann, Constance M.
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- 2021
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9. Modeling hospital energy and economic costs for COVID-19 infection control interventions
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Squire, Marietta M., Munsamy, Megashnee, Lin, Gary, Telukdarie, Arnesh, and Igusa, Takeru
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- 2021
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10. Association between mobility patterns and COVID-19 transmission in the USA: a mathematical modelling study
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Badr, Hamada S, Du, Hongru, Marshall, Maximilian, Dong, Ensheng, Squire, Marietta M, and Gardner, Lauren M
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- 2020
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11. Results of treatment with myo-Inositol and D-chiro inositol combination in ratio 5:1 in women with polycystic ovary syndrome
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Tatiana A. Oboskalova, Anna V. Vorontsova, Maksim A. Zvychainyi, Karina G. Gushchina, and Marietta M. Maitesian
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polycystic ovary syndrome ,myo-inositol ,d-chiro inositol ,dikirogen ,Gynecology and obstetrics ,RG1-991 - Abstract
We conducted an observational descriptive study evaluating the effectiveness of therapeutic modification of lifestyle with adding of 1000 mg of myo-inositol and 200 mg of D-chiro inositol combination (ratio 5:1) for nutritional support in 104 women of reproductive age with polycystic ovary syndrome (classic phenotype and nonclassical phenotypes in the presence of hyperandrogenism) for 6 months. Revealed changes in anthropometric parameters (decrease in body mass index by 0.89 kg/m2; p0.05 and waist circumference by 3.0 cm; p0.05), skin status (decrease in the incidence of acne from 96.2 up to 58.6%; p0.05 and seborrhea from 34.6 to 5.8%; p0.05), hormonal profile (statistically significant change in all studied parameters; p0.05: decrease in total testosterone to 1.27 nmol/L and a free androgen index up to 4.12% under an increase in globulin binding sex hormones), carbohydrate metabolism (normalization of glucose tolerance without the development of hypoglycemia) and restoration of menstrual cycle (MC) parameters (regular MC in 76.9 %; p0.05, MC duration 33.4 days; p0.05) indicate a significant role of stage I therapy in patients with polycystic ovary syndrome and the possible benefits of 1000 mg of myo-inositol and 200 mg of D-chiro inositol combination as a nutritional support.
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- 2020
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12. Contaminated water delivery as a simple and effective method of experimental Salmonella infection
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Donnell, Hope O, Pham, Oanh H, Benoun, Joseph M, Ravesloot-Chvez, Marietta M, and McSorley, Stephen J
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Microbiology ,Biological Sciences ,Emerging Infectious Diseases ,Digestive Diseases ,Foodborne Illness ,Prevention ,Biodefense ,Infectious Diseases ,Vaccine Related ,Aetiology ,2.2 Factors relating to the physical environment ,Infection ,Good Health and Well Being ,Animals ,Disease Models ,Animal ,Drinking Water ,Female ,Intestinal Mucosa ,Mice ,Mice ,Inbred C57BL ,Salmonella Infections ,Animal ,Salmonella typhimurium ,Water Microbiology ,Water Pollution ,alternative infection technique ,experimental stress ,gavage ,intragastric ,natural route ,oral infection ,Salmonella ,water contamination ,Medical Microbiology - Abstract
AimIn most infectious disease models, it is assumed that gavage needle infection is the most reliable means of pathogen delivery to the GI tract. However, this methodology can cause esophageal tearing and induces stress in experimental animals, both of which have the potential to impact early infection and the subsequent immune response.Materials & methodsC57BL/6 mice were orally infected with virulent Salmonella Typhimurium SL1344 either by intragastric gavage preceded by sodium bicarbonate, or by contamination of drinking water.ResultsWe demonstrate that water contamination delivery of Salmonella is equivalent to gavage inoculation in providing a consistent model of infection. Furthermore, exposure of mice to contaminated drinking water for as little as 4 h allowed maximal mucosal and systemic infection, suggesting an abbreviated window exists for natural intestinal entry.ConclusionTogether, these data question the need for gavage delivery for infection with oral pathogens.
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- 2015
13. Mitochondrion-Mediated Cell Death through Erk1-Alox5 Independent of Caspase-9 Signaling
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Min Chen, Lei Wang, Min Li, Marietta M. Budai, and Jin Wang
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caspase-9-independent cell death ,Erk1 ,Alox5 ,ROS ,lipid peroxidation ,Cytology ,QH573-671 - Abstract
Mitochondrial disruption leads to the release of cytochrome c to activate caspase-9 and the downstream caspase cascade for the execution of apoptosis. However, cell death can proceed efficiently in the absence of caspase-9 following mitochondrial disruption, suggesting the existence of caspase-9-independent cell death mechanisms. Through a genome-wide siRNA library screening, we identified a network of genes that mediate caspase-9-independent cell death, through ROS production and Alox5-dependent membrane lipid peroxidation. Erk1-dependent phosphorylation of Alox5 is critical for targeting Alox5 to the nuclear membrane to mediate lipid peroxidation, resulting in nuclear translocation of cytolytic molecules to induce DNA damage and cell death. Consistently, double knockouts of caspase-9 and Alox5 in mice, but not deletion of either gene alone, led to significant T cell expansion with inhibited cell death, indicating that caspase-9- and Alox5-dependent pathways function in parallel to regulate T cell death in vivo. This unbiased whole-genome screening reveals an Erk1-Alox5-mediated pathway that promotes membrane lipid peroxidation and nuclear translocation of cytolytic molecules, leading to the execution of cell death in parallel to the caspase-9 signaling cascade.
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- 2022
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14. Toll-like Receptor and Inflammasome Signals Converge to Amplify the Innate Bactericidal Capacity of T Helper 1 Cells
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O'Donnell, Hope, Pham, Oanh H, Li, Lin-xi, Atif, Shaikh M, Lee, Seung-Joo, Ravesloot, Marietta M, Stolfi, Jessica L, Nuccio, Sean-Paul, Broz, Petr, Monack, Denise M, Baumler, Andreas J, and McSorley, Stephen J
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Biomedical and Clinical Sciences ,Immunology ,Emerging Infectious Diseases ,Vaccine Related ,Infectious Diseases ,Aetiology ,2.1 Biological and endogenous factors ,Inflammatory and immune system ,Infection ,Animals ,Bacterial Load ,CD4 Antigens ,Chlamydia ,Flow Cytometry ,Immunity ,Innate ,Inflammasomes ,Interleukin-18 ,Mice ,Mice ,Inbred C57BL ,Real-Time Polymerase Chain Reaction ,Salmonella ,Signal Transduction ,Th1 Cells ,Toll-Like Receptor 4 ,Toll-Like Receptors - Abstract
T cell effector functions can be elicited by noncognate stimuli, but the mechanism and contribution of this pathway to the resolution of intracellular macrophage infections have not been defined. Here, we show that CD4(+) T helper 1 (Th1) cells could be rapidly stimulated by microbe-associated molecular patterns during active infection with Salmonella or Chlamydia. Further, maximal stimulation of Th1 cells by lipopolysaccharide (LPS) did not require T-cell-intrinsic expression of toll-like receptor 4 (TLR4), interleukin-1 receptor (IL-1R), or interferon-γ receptor (IFN-γR) but instead required IL-18R, IL-33R, and adaptor protein MyD88. Innate stimulation of Th1 cells also required host expression of TLR4 and inflammasome components that together increased serum concentrations of IL-18. Finally, the elimination of noncognate Th1 cell stimulation hindered the resolution of primary Salmonella infection. Thus, the in vivo bactericidal capacity of Th1 cells is regulated by the response to noncognate stimuli elicited by multiple innate immune receptors.
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- 2014
15. Identification of eight novel proteasome variants in five unrelated cases of proteasome-associated autoinflammatory syndromes (PRAAS)
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Papendorf, Jonas Johannes, primary, Ebstein, Frédéric, additional, Alehashemi, Sara, additional, Piotto, Daniela Gerent Petry, additional, Kozlova, Anna, additional, Terreri, Maria Teresa, additional, Shcherbina, Anna, additional, Rastegar, Andre, additional, Rodrigues, Marta, additional, Pereira, Renan, additional, Park, Sophia, additional, Lin, Bin, additional, Uss, Kat, additional, Möller, Sophie, additional, da Silva Pina, Ana Flávia, additional, Sztajnbok, Flavio, additional, Torreggiani, Sofia, additional, Niemela, Julie, additional, Stoddard, Jennifer, additional, Rosenzweig, Sergio D., additional, Oler, Andrew J., additional, McNinch, Colton, additional, de Guzman, Marietta M., additional, Fonseca, Adriana, additional, Micheloni, Nicole, additional, Fraga, Melissa Mariti, additional, Perazzio, Sandro Félix, additional, Goldbach-Mansky, Raphaela, additional, de Jesus, Adriana A., additional, and Krüger, Elke, additional
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- 2023
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16. Development of an Internationalized Dietetic Technician Program for the Milwaukee Area Technical College with a Plan for Implementation and Evaluation.
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Advincula-Carpenter, Marietta M.
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An internationalized dietetic technician (DT) program was developed at the Milwaukee Area Technical College through a process that included the design and development of international modules to be used through infusion or an individual unit approach in selected courses. The following procedures were used: a review of the literature on benefits of international education, models to internationalize curriculum, appropriate instructional design, and appropriate tools to evaluate program impact; establishment of formative committees to provide feedback during the developmental process; establishment of a process for the internationalization of the DT program; use of the framework developed by the author to internationalize the selected courses; establishment of a summative committee to provide feedback on program content and face validity; and development of plans for program implementation and evaluation. Of 15 technical courses in the program, 7 were internationalized by infusion and 8 by the addition of a new unit. The process of infusion was accomplished by adding an internationalized competency or competencies in an existing unit. Evaluation was planned for two years after program implementation. (Contains 129 references. Appendixes include: DT curriculum; diagram of the internationalization process; committee reports; guidebook of internationalized DT courses, with a course outcome summary and example lesson plan; and list of 241 academic support resources.) (YLB)
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- 1996
17. Comparison of Responses on the 1994 Biennial Student Survey by the Consumer and Hospitality Services Division and Overall Students of the Milwaukee Area Technical College.
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Advincula-Carpenter, Marietta M.
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To gather curriculum planning information, the Research, Planning and Development Division of Milwaukee Area Technical College (MATC) conducts student surveys biennially. Responses of 579 MATC students enrolled in consumer and hospitality services division (CHSD) programs to the 1994 survey were compared with those of the 5,071 students constituting MATC's overall student population. Special attention was paid to students' reasons for attending MATC, educational background, major objectives for taking courses at MATC, and student status. Compared to the overall student population, the CHSD students were more likely to be female, have a lower average family income, have chosen MATC based on program rather than on schedule and/or cost, already have a vocational diploma/certificate, and be a full-time student. For both groups, the three biggest factors influencing their decision to attend MATC were the following: class schedule; printed mailed materials, and parents, relatives, and current/former MATC students. The following were among the study recommendations: (1) each program in the CHSD should be promoted to the entire MATC service area; (2) brochures/printed materials should reflect diversity of students and successful graduates; and (3) programs should address students' and industry's need for short-term programs providing skills facilitating employment. (The bibliography contains 11 references. Appended are key study findings and recommendations.) (MN)
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- 1995
18. An Evaluation of the Human Relations Workshops and Training Programs.
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Advincula-Carpenter, Marietta M.
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The human relations task force of Milwaukee Area Technical College (MATC) sponsors a workshop series to improve human relations/productivity at the college. A practicum study evaluated the workshops by using the postworkshop training evaluation forms completed by workshop participants from 1990 to 1994. Data from a literature review were also incorporated into the evaluation. Of the 202 past workshop participants surveyed, 145 (72%) believed that the workshops trained them to discuss and resolve differences with college objectives and 182 (90%) credited the workshops with helping them treat people with more understanding. Although most participants believed that the workshops increased their understanding of coworkers who are ethnically and culturally different from them, only 32%-46% stated that the workshops improved their understanding of coworkers with disabilities, and 22 (11%) stated that they still did not understand their disabled coworkers after having attended the workshops. It was recommended that the workshops be continued but that their curriculum be modified to include modules on dealing with disabled individuals and that future workshops be offered to part-time faculty and staff. (The bibliography contains 34 references. Appended are lists of task force members and recommendations and postworkshop training evaluation forms and responses to it.) (MN)
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- 1994
19. Unique Auditory Language-Learning Needs of Hearing-Impaired Children: Implications for Intervention.
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Johnson, Barbara Ann and Paterson, Marietta M.
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Twenty-seven hearing-impaired young adults with hearing potentially usable for language comprehension and a history of speech language therapy participated in this study of training in using residual hearing for the purpose of learning spoken language. Evaluation of their recalled therapy experiences indicated that listening to spoken language did not emerge as a memorable speech therapy activity for 81 percent of the subjects. This may indicate that essential listening practice was either neglected or minimized during speech language therapy. Subjects demonstrated poor listening skills (70 percent scored at chance or below on the listening task), and two-thirds reported negative feelings toward listening practice and thought that listening training would not be expected in a speech language therapy program. Study recommendations stress the need to identify clients with potentially usable aided audition and maximize their listening capabilities through training. (16 references) (DB)
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- 1991
20. Regulation of type I interferon responses by mitochondria-derived reactive oxygen species in plasmacytoid dendritic cells
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Zsofia Agod, Tünde Fekete, Marietta M. Budai, Aliz Varga, Attila Szabo, Hyelim Moon, Istvan Boldogh, Tamas Biro, Arpad Lanyi, Attila Bacsi, and Kitti Pazmandi
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Plasmacytoid dendritic cell ,Mitochondrial ROS ,Type I interferon ,Endosomal TLR signaling ,RIG-I signaling ,Antiviral response ,Medicine (General) ,R5-920 ,Biology (General) ,QH301-705.5 - Abstract
Mitochondrial reactive oxygen species (mtROS) generated continuously under physiological conditions have recently emerged as critical players in the regulation of immune signaling pathways. In this study we have investigated the regulation of antiviral signaling by increased mtROS production in plasmacytoid dendritic cells (pDCs), which, as major producers of type I interferons (IFN), are the key coordinators of antiviral immunity. The early phase of type I IFN production in pDCs is mediated by endosomal Toll-like receptors (TLRs), whereas the late phase of IFN response can also be triggered by cytosolic retinoic acid-inducible gene-I (RIG-I), expression of which is induced upon TLR stimulation. Therefore, pDCs provide an ideal model to study the impact of elevated mtROS on the antiviral signaling pathways initiated by receptors with distinct subcellular localization. We found that elevated level of mtROS alone did not change the phenotype and the baseline cytokine profile of resting pDCs. Nevertheless increased mtROS levels in pDCs lowered the TLR9-induced secretion of pro-inflammatory mediators slightly, whereas reduced type I IFN production markedly via blocking phosphorylation of interferon regulatory factor 7 (IRF7), the key transcription factor of the TLR9 signaling pathway. The TLR9-induced expression of RIG-I in pDCs was also negatively regulated by enhanced mtROS production. On the contrary, elevated mtROS significantly augmented the RIG-I-stimulated expression of type I IFNs, as well as the expression of mitochondrial antiviral-signaling (MAVS) protein and the phosphorylation of Akt and IRF3 that are essential components of RIG-I signaling. Collectively, our data suggest that increased mtROS exert diverse immunoregulatory functions in pDCs both in the early and late phase of type I IFN responses depending on which type of viral sensing pathway is stimulated.
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- 2017
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21. Diagnosis and management of 365 ureteric injuries following obstetric and gynecologic surgery in resource-limited settings
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Raassen, Thomas J. I. P., Ngongo, Carrie J., and Mahendeka, Marietta M.
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- 2018
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22. Hospital energy demand forecasting for prioritisation during periods of constrained supply
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Munsamy, Megashnee, primary, Telukdarie, Arnesh, additional, Igusa, Takeru, additional, and Squire, Marietta M, additional
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- 2023
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23. Targeting HIV-1 reservoirs in T cell subsets
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Li, Min, primary, Budai, Marietta M., additional, Chen, Min, additional, and Wang, Jin, additional
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- 2023
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24. Performance Assessment for the Waste Isolation Pilot Plant: From Regulation to Calculation for 40 CFR 191.13
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Helton, J. C., Anderson, D. R., Marietta, M. G., and Rechard, R. P.
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- 1997
25. Does psychotherapy work with school-aged youth? A meta-analytic examination of moderator variables that influence therapeutic outcomes
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Fedewa, Alicia L., Ahn, Soyeon, Reese, Robert J., Suarez, Marietta M., Macquoid, Ahjane, Davis, Matthew C., and Prout, H. Thompson
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- 2016
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26. Protection of Quiescence and Longevity of IgG Memory B Cells by Mitochondrial Autophagy
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Srikanth Kodali, Min Li, Marietta M. Budai, Min Chen, and Jin Wang
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Mice, Knockout ,Fatty Acids ,Longevity ,Immunology ,Mitophagy ,Membrane Proteins ,Adoptive Transfer ,Article ,Oxidative Phosphorylation ,Mitochondria ,Mice, Inbred C57BL ,Mitochondrial Proteins ,Mice ,Memory B Cells ,Immunoglobulin G ,Receptor-Interacting Protein Serine-Threonine Kinases ,Necroptosis ,Animals ,Homeostasis ,Immunology and Allergy ,RNA Interference ,RNA, Small Interfering ,Immunologic Memory - Abstract
The development of long-lived immune memory cells against pathogens is critical for the success of vaccines to establish protection against future infections. However, the mechanisms governing the long-term survival of immune memory cells remain to be elucidated. In this article, we show that the maintenance mitochondrial homeostasis by autophagy is critical for restricting metabolic functions to protect IgG memory B cell survival. Knockout of mitochondrial autophagy genes, Nix and Bnip3, leads to mitochondrial accumulation and increases in oxidative phosphorylation and fatty acid synthesis, resulting in the loss of IgG+ memory B cells in mice. Inhibiting fatty acid synthesis or silencing necroptosis gene Ripk3 rescued Nix−/−Bnip3−/− IgG memory B cells, indicating that mitochondrial autophagy is important for limiting metabolic functions to prevent cell death. Our results suggest a critical role for mitochondrial autophagy in the maintenance of immunological memory by protecting the metabolic quiescence and longevity of memory B cells.
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- 2022
27. Autoantibodies Recognizing Specificity Protein 4 Co‐occur With Anti–Transcription Intermediary Factor 1 and Are Associated With Distinct Clinical Features and Immunogenetic Risk Factors in Juvenile Myositis.
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Sherman, Matthew A., Pak, Katherine, Pinal‐Fernandez, Iago, Flegel, Willy A., Targoff, Ira N., Miller, Frederick W., Rider, Lisa G., Mammen, Andrew L., Albert, Daniel A., Arabshahi, Bita, Balboni, Imelda M., Ballinger, Susan, Bayat, Nastaran, Bingham, C. April, Bohnsack, John F., Cartwright, Victoria W., Cron, Randy Q., Curiel, Rodolfo, de la Pena, Wendy, and de Guzman, Marietta M.
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AUTOANTIBODIES ,PROTEINS ,RISK assessment ,DISEASE susceptibility ,DESCRIPTIVE statistics ,RESEARCH funding ,MYOSITIS ,TRANSCRIPTION factors ,AMINOTRANSFERASES ,PHENOTYPES ,DISEASE risk factors ,CHILDREN ,ADOLESCENCE - Abstract
Objective: Autoantibodies recognizing specificity protein 4 (Sp4) were recently discovered in adults with idiopathic inflammatory myopathies (IIM). Anti‐Sp4 autoantibodies co‐occurred in patients with anti–transcription intermediary factor 1 (anti‐TIF1) autoantibody‐positive dermatomyositis (DM) and were associated with a reduced risk of cancer. In the present study, the prevalence and clinical features associated with anti‐Sp4 autoantibodies in juvenile‐onset IIM were investigated. Methods: Serum samples from 336 patients with juvenile myositis in a cross‐sectional cohort and 91 healthy controls were screened for anti‐Sp4 autoantibodies using enzyme‐linked immunosorbent assay. Clinical characteristics, outcomes, and HLA alleles of those with and those without anti‐Sp4 autoantibodies were compared. Results: Anti‐Sp4 autoantibodies were present in 23 patients (7%) with juvenile myositis and were not present in any of the controls. Anti‐Sp4 autoantibodies were found among each clinical myositis subgroup. The frequency of TIF1 autoantibody positivity was significantly higher among those with anti‐Sp4 autoantibodies (21 [91%] versus 92 [30%], P < 0.001). In the anti‐TIF1 autoantibody–positive subgroup, Raynaud's phenomenon (8 [38%] versus 2 [2%], P < 0.001) was more common and peak aspartate aminotransferase was significantly lower in those with anti‐Sp4 autoantibodies. None of the patients with anti‐Sp4 autoantibodies required a wheelchair. Among White patients, DQA1*04 and DRB1*08 were associated with anti‐Sp4 autoantibodies. Conclusion: Anti‐Sp4 autoantibodies were found in patients with juvenile‐onset IIM, predominantly those with coexisting anti‐TIF1 autoantibodies. Patients with anti‐Sp4 autoantibodies represent a phenotypic subset of anti‐TIF1 autoantibody–positive myositis characterized by frequent Raynaud's phenomenon and less pronounced muscle involvement, similar to adults with these autoantibodies. Novel immunogenetic risk factors for White patients with IIM were identified among juveniles with anti‐Sp4 autoantibodies. [ABSTRACT FROM AUTHOR]
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- 2023
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28. HSCT corrects primary immunodeficiency and immune dysregulation in patients with POMP-related autoinflammatory disease
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Jordan S. Orange, Riccardo Castagnoli, Elke Krüger, Marita Bosticardo, Robert A. Krance, Marietta M. de Guzman, Luigi D. Notarangelo, Lisa R. Forbes, M. Cecilia Poli, Ottavia M. Delmonte, Caridad Martinez, Frédéric Ebstein, and Sarah K. Nicholas
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0301 basic medicine ,business.industry ,Immunology ,Cell Biology ,Hematology ,Disease ,Immune dysregulation ,medicine.disease ,medicine.disease_cause ,Biochemistry ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Immune system ,Proteasome ,Immunity ,Proteasome assembly ,Primary immunodeficiency ,Medicine ,Letter to Blood ,business ,Immunodeficiency ,030215 immunology - Abstract
Inborn errors of immunity that present with concomitant immunodeficiency and auto-inflammation are therapeutically challenging; furthermore, complexity is added when they are caused by mutations in genes that encode for proteins expressed beyond immune cells. The ubiquitin-proteasome system is the main intracellular proteolytic machinery and participates in most cellular processes by degrading ubiquitinated proteins. Mutations in proteasome subunits resulting in proteasome deficiency cause a severe auto-inflammatory disease characterized by chronic auto-inflammation neutrophilic dermatosis and fever, collectively referred to as Proteasome Associated Auto-inflammatory Syndromes (PRAAS). POMP is a chaperone for proteasome assembly and AD mutations in POMP cause a form of PRAAS with prominent immunodeficiency referred to as POMP-related auto-inflammation and immune dysregulation (PRAID) manifesting with recurrent, severe and opportunistic infections in addition to inflammatory features that are characteristic for all PRAAS disorders, most importantly early-onset neutrophilic dermatosis. JAK inhibitors partially control the disease in individuals with PRAAS, however life-threatening, recurrent and opportunistic infections in patients with POMP mutations limit immunosuppressive therapies and prompted consideration of hematopoietic stem cell transplant (HSCT). We describe successful HSCT in two patients with POMP deficiency. Despite POMP being ubiquitously expressed, the immunologic and auto-inflammatory phenotype were both ameliorated through HSCT which suggests that the clinical and immunological features of PRAID are predominantly derived from a proteasome defect in hematopoietic cells. To our knowledge, these are the first patients with a form of PRAAS cured by HSCT, opening new therapeutic possibilities for these diseases.
- Published
- 2021
29. Cure Characteristics and Mechanical Properties of Rubber Compound Reinforced with Activated Carbon from Coconut Husks as Alternative to Carbon Black
- Author
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Ivy Ann C. Razonado, Marietta M. Valdez-Liu, Miguel Lorenzo H. Yorro, Mitch Irene Kate Oyales, and Leslie Joy L. Diaz
- Subjects
021110 strategic, defence & security studies ,Materials science ,Mechanical Engineering ,0211 other engineering and technologies ,02 engineering and technology ,Carbon black ,Condensed Matter Physics ,Husk ,Natural rubber ,Mechanics of Materials ,visual_art ,medicine ,visual_art.visual_art_medium ,General Materials Science ,021108 energy ,Composite material ,Activated carbon ,medicine.drug - Abstract
Selection of raw materials for rubber products is an important aspect of rubber engineering. One of the components often investigated is the filler material, wherein among the considerations include reinforcing capability, cost, and environmental impact. In this study, a greener alternative to carbon black (CB) was explored using activated carbon (AC) from coconut husk. Results showed that AC has lower fixed carbon content (33.64 wt%C) than CB (96.92 wt%C) due to the retained volatile organic components. AC also has a larger particle size distribution (< 150μm) in terms of 80% passing than CB (which is 28-36 nm for technically specified particle size of commercial N330). However, AC exhibits larger BET surface area (423.66 m2/g) due to natural porosity of activated carbon materials as compared to CB (58.109 m2/g). Moreover, AC was found to be basic while CB has a neutral pH. Consequently, the tensile strength and complex modulus G* of the AC-compound (4.3 MPa and 75.36 kPa, respectively) are inferior to CB-compound (20.3 MPa and 87.41 kPa, respectively). This is thought to be mainly due to the larger particle size and porous structure of the activated carbon. Yet, the % elongation and hardness values are comparable. Processability may also be a concern in using activated carbon as a filler due to higher Mooney viscosity (45.8 M). Nonetheless, the scorch time and cure index of the two compounds were found to be comparable. Hence, the potential of complete replacement of carbon black with activated carbon is viable for rubber products with low tensile strength requirements, such as protective matting.
- Published
- 2021
30. Mitochondrion-Mediated Cell Death through Erk1-Alox5 Independent of Caspase-9 Signaling
- Author
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Chen, Min, primary, Wang, Lei, additional, Li, Min, additional, Budai, Marietta M., additional, and Wang, Jin, additional
- Published
- 2022
- Full Text
- View/download PDF
31. Outcome of intracranial electroencephalography monitoring and surgery in magnetic resonance imaging-negative temporal lobe epilepsy
- Author
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Lee, Ricky W., Hoogs, Marietta M., Burkholder, David B., Trenerry, Max R., Drazkowski, Joseph F., Shih, Jerry J., Doll, Karey E., Tatum, William O., IV, Cascino, Gregory D., Marsh, W. Richard, Wirrell, Elaine C., Worrell, Gregory A., and So, Elson L.
- Published
- 2014
- Full Text
- View/download PDF
32. Severe bleeding in critical care
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Girardis, M., Busani, S., Marietta, M., and Gullo, Antonino, editor
- Published
- 2006
- Full Text
- View/download PDF
33. Interrogation of STAT3 activation in patients with polyarticular juvenile arthritis
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Wood, Stephanie Leigh, primary, Branch, Justin, additional, Vasquez, Pricilla, additional, DeGuzman, Marietta M., additional, Brown, Amanda, additional, Sagcal Gironella, A. Carmela, additional, Singla, Saimun, additional, Ramirez, Andrea, additional, and Vogel, Tiphanie P., additional
- Published
- 2022
- Full Text
- View/download PDF
34. Regulation of Mitochondrial Homeostasis and Metabolic Programming in Memory B cells by Mitophagy
- Author
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Budai, Marietta M., primary, Li, Min, additional, Kodali, Srikanth, additional, Chen, Min, additional, and Wang, Jin, additional
- Published
- 2022
- Full Text
- View/download PDF
35. The University of Hartford and CREC Soundbridge: A New Master's of Education in Aural Habilitation and Education of Hearing Impaired Children
- Author
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Paterson, Marietta M. and Cole, Elizabeth
- Abstract
This profile describes the University of Hartford's new Master of Education degree program in Aural Habilitation and Education of Hearing-Impaired Children. The Aural Habilitation and Education graduate program was conceptualized as a model partnership between Capitol Region Education Council (CREC) Soundbridge, the largest public provider of services to children who are deaf or hard of hearing and their families in Connecticut, and the University of Hartford, "a private university with a public purpose." The program was specifically created to address the nationally recognized need to increase the quality and quantity of professionals in auditory-based deaf education who are prepared to work with advanced hearing technology to promote the listening and spoken language development of children who are deaf or hard of hearing. As a result of 9 years of sustained effort, planning, and approvals, the program was launched in July 2007. (Contains 1 table.)
- Published
- 2010
36. Optimal Design of Paired Built Environment Interventions for Control of MDROs in Acute Care and Community Hospitals
- Author
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Marietta M. Squire, Edward N. Squire, Gary Lin, Takeru Igusa, and Gareth K. Sessel
- Subjects
Methicillin-Resistant Staphylococcus aureus ,medicine.medical_specialty ,Quality management ,Control (management) ,Psychological intervention ,Hospitals, Community ,Critical Care and Intensive Care Medicine ,Vancomycin-Resistant Enterococci ,03 medical and health sciences ,Patient safety ,0302 clinical medicine ,Drug Resistance, Multiple, Bacterial ,Acute care ,medicine ,Humans ,Infection control ,030212 general & internal medicine ,Built Environment ,Intensive care medicine ,Built environment ,Cross Infection ,0303 health sciences ,030306 microbiology ,business.industry ,Public Health, Environmental and Occupational Health ,Direct cost ,business - Abstract
Objectives: Our goal was to optimize infection control of paired environmental control interventions within hospitals to reduce methicillin-resistant Staphylococcus aureus (MRSA), carbapenem-resistant Enterobacteriaceae (CRE), and vancomycin-resistant Enterococci (VRE). Background: The most widely used infection control interventions are deployment of handwashing (HW) stations, control of relative humidity (RH), and negative pressure (NP) treatment rooms. Direct costs of multidrug-resistant organism (MDRO) infections are typically not included in the design of such interventions. Methods: We examined the effectiveness of pairing HW with RH and HW with NP. We used the following three data sets: A meta-analysis of progression rates from uncolonized to colonized to infected, 6 years of MDRO treatment costs from 400 hospitals, and 8 years of MDRO incidence rates at nine army hospitals. We used these data as inputs into an Infection De-Escalation Model with varying budgets to obtain optimal intervention designs. We then computed the infection and prevention rates and cost savings resulting from these designs. Results: The average direct cost of an MDRO infection was $3,289, $1,535, and $1,067 for MRSA, CRE, and VRE. The mean annual incidence rates per facility were 0.39%, 0.034%, and 0.011% for MRSA, CRE, and VRE. After applying the cost-minimizing intervention pair to each scenario, the percentage reductions in infections (and annual direct cost savings) in large, community, and small acute care hospitals were 69% ($1.5 million), 73% ($631K), 60% ($118K) for MRSA, 52% ($460.5K), 58% ($203K), 50% ($37K) for CRE, and 0%, 0%, and 50% ($12.8K) for VRE. Conclusion: The application of this Infection De-Escalation Model can guide cost-effective decision making in hospital built environment design to improve control of MDRO infections.
- Published
- 2020
37. Results of treatment with myo-Inositol and D-chiro inositol combination in ratio 5:1 in women with polycystic ovary syndrome
- Author
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Maksim A. Zvychainyi, Tatiana A. Oboskalova, Anna V. Vorontsova, Karina G. Gushchina, and Marietta M. Maitesian
- Subjects
medicine.medical_specialty ,myo-inositol ,media_common.quotation_subject ,Hypoglycemia ,lcsh:Gynecology and obstetrics ,chemistry.chemical_compound ,Internal medicine ,medicine ,Inositol ,lcsh:RG1-991 ,Menstrual cycle ,media_common ,D-chiro-Inositol ,business.industry ,Free androgen index ,Hyperandrogenism ,Obstetrics and Gynecology ,dikirogen ,medicine.disease ,Polycystic ovary ,Endocrinology ,chemistry ,polycystic ovary syndrome ,d-chiro inositol ,business ,Body mass index - Abstract
We conducted an observational descriptive study evaluating the effectiveness of therapeutic modification of lifestyle with adding of 1000 mg of myo-inositol and 200 mg of D-chiro inositol combination (ratio 5:1) for nutritional support in 104 women of reproductive age with polycystic ovary syndrome (classic phenotype and nonclassical phenotypes in the presence of hyperandrogenism) for 6 months. Revealed changes in anthropometric parameters (decrease in body mass index by 0.89 kg/m 2 ; p
- Published
- 2020
38. Hereditary fibrosing poikiloderma with tendon contractures, myopathy, and pulmonary fibrosis: Hepatic disease in a child with a novel pathogenic variant of FAM111B
- Author
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Kalyani R. Patel, Thuy L. Phung, Paula M. Hertel, Yelena Dokic, Marietta M. de Guzman, Raegan D. Hunt, and Yasser Albahrani
- Subjects
Systemic disease ,medicine.medical_specialty ,Poikiloderma ,Case Report ,Dermatology ,systemic disease ,hereditary fibrosing poikiloderma ,hepatomegaly ,Pulmonary fibrosis ,medicine ,lcsh:Dermatology ,transaminitis ,genetics ,Myopathy ,hypohidrosis ,liver biopsy ,Muscle contracture ,Hypopigmentation ,FAM111B ,medicine.diagnostic_test ,pulmonary fibrosis ,business.industry ,poikiloderma ,cutaneous manifestation of systemic disease ,pancreatic insufficiency ,tendon contractures ,lcsh:RL1-803 ,medicine.disease ,POIKTMP, hereditary fibrosing poikiloderma with tendon contracture, myopathy, and pulmonary fibrosis ,Tendon ,medicine.anatomical_structure ,nonscarring alopecia ,Liver biopsy ,POIKTMP ,muscle contractures ,medicine.symptom ,business ,hypopigmentation ,FAM111B gene ,myopathy - Published
- 2020
39. Clearance of HIV-1 or SIV reservoirs by promotion of apoptosis and inhibition of autophagy: Targeting intracellular molecules in cure-directed strategies
- Author
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Min Chen, Min Li, Marietta M Budai, Andrew P Rice, Jason T Kimata, Mahesh Mohan, and Jin Wang
- Subjects
CD4-Positive T-Lymphocytes ,Immunology ,NF-kappa B ,HIV Infections ,Apoptosis ,Cell Biology ,Macaca mulatta ,Virus Latency ,Transcription Factor AP-1 ,Mice ,HIV-1 ,Autophagy ,Immunology and Allergy ,Animals ,Myeloid Cell Leukemia Sequence 1 Protein ,Virus Activation - Abstract
The reservoirs of the HIV display cellular properties resembling long-lived immune memory cells that could be exploited for viral clearance. Our interest in developing a cure for HIV stems from the studies of immunologic memory against infections. We and others have found that long-lived immune memory cells employ prosurvival autophagy and antiapoptotic mechanisms to protect their longevity. Here, we describe the rationale for the development of an approach to clear HIV-1 by selective elimination of host cells harboring replication-competent HIV (SECH). While reactivation of HIV-1 in the host cells with latency reversing agents (LRAs) induces viral gene expression leading to cell death, LRAs also simultaneously up-regulate prosurvival antiapoptotic molecules and autophagy. Mechanistically, transcription factors that promote HIV-1 LTR-directed gene expression, such as NF-κB, AP-1, and Hif-1α, can also enhance the expression of cellular genes essential for cell survival and metabolic regulation, including Bcl-xL, Mcl-1, and autophagy genes. In the SECH approach, we inhibit the prosurvival antiapoptotic molecules and autophagy induced by LRAs, thereby allowing maximum killing of host cells by the induced HIV-1 proteins. SECH treatments cleared HIV-1 infections in humanized mice in vivo and in HIV-1 patient PBMCs ex vivo. SECH also cleared infections by the SIV in rhesus macaque PBMCs ex vivo. Research efforts are underway to improve the efficacy and safety of SECH and to facilitate the development of SECH as a therapeutic approach for treating people with HIV.
- Published
- 2022
40. The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages
- Author
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Czimmerer, Zsolt, Daniel, Bence, Horvath, Attila, Rückerl, Dominik, Nagy, Gergely, Kiss, Mate, Peloquin, Matthew, Budai, Marietta M., Cuaranta-Monroy, Ixchelt, Simandi, Zoltan, Steiner, Laszlo, Nagy, Bela, Jr., Poliska, Szilard, Banko, Csaba, Bacso, Zsolt, Schulman, Ira G., Sauer, Sascha, Deleuze, Jean-Francois, Allen, Judith E., Benko, Szilvia, and Nagy, Laszlo
- Published
- 2018
- Full Text
- View/download PDF
41. Clearance of HIV-1 or SIV reservoirs by promotion of apoptosis and inhibition of autophagy: Targeting intracellular molecules in cure-directed strategies
- Author
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Chen, Min, primary, Li, Min, additional, Budai, Marietta M, additional, Rice, Andrew P, additional, Kimata, Jason T, additional, Mohan, Mahesh, additional, and Wang, Jin, additional
- Published
- 2022
- Full Text
- View/download PDF
42. Protection of Quiescence and Longevity of IgG Memory B Cells by Mitochondrial Autophagy
- Author
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Kodali, Srikanth, primary, Li, Min, additional, Budai, Marietta M., additional, Chen, Min, additional, and Wang, Jin, additional
- Published
- 2022
- Full Text
- View/download PDF
43. Iatrogenic genitourinary fistula: an 18-year retrospective review of 805 injuries
- Author
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Raassen, Thomas J. I. P., Ngongo, Carrie J., and Mahendeka, Marietta M.
- Published
- 2014
- Full Text
- View/download PDF
44. Domestic Violence: Nashville's Increased Response
- Author
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Shipley, Marietta M.
- Published
- 2010
- Full Text
- View/download PDF
45. Results from a Comparison of Geostatistical Inverse Techniques for Groundwater Flow : Transmissivity Fields and Groundwater Travel Time CDFs
- Author
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Zimmerman, D. A., Axness, C. L., De Marsily, G., Marietta, M. G., Gotway, C. A., Singh, V. P., editor, Gottlieb, Johannes, editor, and DuChateau, Paul, editor
- Published
- 1996
- Full Text
- View/download PDF
46. Prevalence and significance of anti-prothrombin (aPT) antibodies in patients with Lupus Anticoagulant (LA)
- Author
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Pengo, V., Denas, G., Bison, E., Banzato, A., Padayattil Jose, S., Gresele, P., Marongiu, F., Erba, N., Veschi, F., Ghirarduzzi, A., De Candia, E., Montaruli, B., Marietta, M., Testa, S., Barcellona, D., and Tripodi, A.
- Published
- 2010
- Full Text
- View/download PDF
47. Position paper on the safety/efficacy profile of direct oral anticoagulants in patients with chronic kidney disease. Consensus document from the SIN, FCSA and SISET
- Author
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Grandone, E, Aucella, F, Barcellona, D, Brunori, G, Forneris, G, Gresele, P, Marietta, M, Poli, D, Testa, S, Tripodi, A, Genovesi, Sc., Grandone, E, Aucella, F, Barcellona, D, Brunori, G, Forneris, G, Gresele, P, Marietta, M, Poli, D, Testa, S, Tripodi, A, and Genovesi, S
- Subjects
Metabolic Clearance Rate ,Pyridines ,Pyridones ,Direct anticoagulants, chronic kidney disease, stroke, bleeding ,Antidotes ,Administration, Oral ,Hemorrhage ,urologic and male genital diseases ,Kidney ,Antithrombins ,Haemostasis and Thrombosis ,Cohort Studies ,Rivaroxaban ,Atrial Fibrillation ,Humans ,Drug Interactions ,Renal Insufficiency, Chronic ,Randomized Controlled Trials as Topic ,Dabigatran ,Stroke ,Observational Studies as Topic ,Thiazoles ,Practice Guidelines as Topic ,Polypharmacy ,Pyrazoles ,Drug Monitoring ,Glomerular Filtration Rate - Abstract
Direct oral anticoagulants (DOAC) are mostly prescribed to prevent cardioembolic stroke in patients with non-valvular atrial fibrillation (AF). An increasing number of guidelines recommend DOAC in AF patients with preserved renal function for the prevention of thromboembolism, and an increased use of DOAC in daily practice has been recorded also in elderly patients. Ageing is associated with a reduction in glomerular filtration rate, and impaired renal function, regardless of the cause, increases the risk of bleeding. Multiple medication use (polypharmacy) for treating superimposed co-morbidities is common in both elderly and chronic kidney disease (CKD) patients and drug-drug interaction may cause accumulation of DOAC, thereby increasing the risk of bleeding. The safety profile of DOAC in patients with CKD has not been defined with any certainty, particularly in those with severely impaired renal function or end stage renal disease. This has been due to the heterogeneity of studies and the relative paucity of data. This document reports the position of three Italian scientific societies engaged in the management of patients with atrial fibrillation who are treated with DOAC and present with CKD.
- Published
- 2020
48. New data from the italian national register of congenital coagulopathies, 2016 annual survey
- Author
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Abbonizio F., Hassan H. J., Riccioni R., Santagostino E., Arcieri R., Giampaolo A., Contino L., Accorsi A., Caremani A., Ettorre P. C., Giordano P., Lassandro G., Valdre L., Notarangelo L., Aru A. B., Radossi P., Tagariello G., Cultrera D., Iannaccaro P., Santoro R., Biasoli C., Di Gregorio P., Daniele F., Testa S., Serino M. L., Castaman G., Linari S. S., Morfini M., Molinari A. C., Delios G., Cantori I., Franchini M., Caimi M. T., Mancuso M. E., Peyvandi F., Marietta M., Todisco A., Speciale V., Cerbone A. M., Di Minno G., Schiavulli M., Rocino A., Spiezia M. M., Zanon E., Gagliano F., Mansueto M. F., Siragusa S., Coppola A., Quintavalle G., Rivolta G. F., Tagliaferri A., Ambaglio C., Gamba G., Marchesini E., Oliovecchio E., Dragani A., Arbasi M. C., MacChi S., Vincenzi D., Sottilotta G., Pizzini A. M., Luciani M., De Cristofaro R., Baldacci E., Mazzucconi M. G., Santoro C., Mameli L. A., Coluccia A., Marino P., Borchiellini A., Schinco P. C., Messina M., Pollio B., Ricca I., Agostini P., Cristallo A. F., Barillari G., De Angelis V., Mosanghini M. E., Feola G., Bonetti E., Cesaro S., Gandini G., Giuffrida A., Tosetto A., Abbonizio, F., Hassan, H. J., Riccioni, R., Santagostino, E., Arcieri, R., Giampaolo, A., Contino, L., Accorsi, A., Caremani, A., Ettorre, P. C., Giordano, P., Lassandro, G., Valdre, L., Notarangelo, L., Aru, A. B., Radossi, P., Tagariello, G., Cultrera, D., Iannaccaro, P., Santoro, R., Biasoli, C., Di Gregorio, P., Daniele, F., Testa, S., Serino, M. L., Castaman, G., Linari, S. S., Morfini, M., Molinari, A. C., Delios, G., Cantori, I., Franchini, M., Caimi, M. T., Mancuso, M. E., Peyvandi, F., Marietta, M., Todisco, A., Speciale, V., Cerbone, A. M., Di Minno, G., Schiavulli, M., Rocino, A., Spiezia, M. M., Zanon, E., Gagliano, F., Mansueto, M. F., Siragusa, S., Coppola, A., Quintavalle, G., Rivolta, G. F., Tagliaferri, A., Ambaglio, C., Gamba, G., Marchesini, E., Oliovecchio, E., Dragani, A., Arbasi, M. C., Macchi, S., Vincenzi, D., Sottilotta, G., Pizzini, A. M., Luciani, M., De Cristofaro, R., Baldacci, E., Mazzucconi, M. G., Santoro, C., Mameli, L. A., Coluccia, A., Marino, P., Borchiellini, A., Schinco, P. C., Messina, M., Pollio, B., Ricca, I., Agostini, P., Cristallo, A. F., Barillari, G., De Angelis, V., Mosanghini, M. E., Feola, G., Bonetti, E., Cesaro, S., Gandini, G., Giuffrida, A., and Tosetto, A.
- Subjects
Blood coagulation disorder ,Haemophilia B ,Haemophilia A ,Von Willebrand's disease ,Register - Abstract
Background - In Italy, the National Register of Congenital Coagulopathies (NRCC) collects epidemiological and therapeutic data from patients affected by haemophilia A (HA), haemophilia B (HB), von Willebrand's disease (vWD) and other rare coagulation disorders. Here we present data from the 2016 annual survey. Materials and methods - Data are provided by the Italian Haemophilia Centres, on a voluntary basis. Information flows from every Centre to a web-based platform of the Italian Association of Haemophilia Centres, shared with the Italian National Institute of Health, in accordance with current privacy laws. Patients are classified by diagnosis, disease severity, age, gender and treatment-related complications. Results - In 2016, the total number of patients with congenital coagulopathies in the NRCC was 10,360: 39.8% of these patients had HA, 31.5% had vWD, 8.5% had HB, and 20.2% had less common factor deficiencies. The overall prevalence of HA and HB was 13.9/100,000 males and 3.0/100,000 males, respectively. The overall prevalence of vWD was 5.4/100,000 inhabitants. During 2016, 126 patients had current alloantibodies to factor VIII (FVIII) or factor IX (FIX) and were under treatment with bypassing agents and/or immune tolerance induction. Overall, 388 patients with a history of alloantibodies were recorded in the NRCC of whom 337 with severe HA and 12 with severe HB. Coagulation factor use, evaluated from treatment plans, was approximately 451,000,000 IU of FVIII for HA patients (7.5 IU/inhabitant), and approximately 53,000,000 IU of FIX for HB patients (0.9 IU/inhabitant). Discussion - The prevalences of HA and HB fall within the ranges reported in more developed countries; the consumption of FVIII and FIX was in line with that of other European countries (France, United Kingdom) and Canada. The NRCC, with its bleeding disorder dataset, is a helpful tool for shaping public health policies, as well as planning clinical and epidemiological research projects.
- Published
- 2020
49. Physical activity improved by adherence to prophylaxis in an Italian population of children, adolescents and adults with severe haemophilia A: The SHAPE Study
- Author
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Zanon, E., Tagliaferri, A., Pasca, S., Ettorre, C. P., Notarangelo, L. D., Biasioli, C., Aru, A. B., Milan, M., Linari, S., Rocino, A., Gagliano, F., Di Minno, G., Gamba, G., Santoro, R. C., Schinco, P., Marietta, M., Seuser, A., Von MacKensen, S., Zanon, E., Tagliaferri, A., Pasca, S., Ettorre, C. P., Notarangelo, L. D., Biasioli, C., Aru, A. B., Milan, M., Linari, S., Rocino, A., Gagliano, F., Di Minno, G., Gamba, G., Santoro, R. C., Schinco, P., Marietta, M., Seuser, A., and Von MacKensen, S.
- Subjects
Adult ,Male ,Factor VIII ,Severe haemophilia ,Adolescent ,Adherence to treatment ,FVIII replacement therapy ,Orthopaedic haemophilia scores ,Physical activity ,Child ,Exercise ,Female ,Hemophilia A ,Humans ,Italy ,Patient Compliance ,Prospective Studies ,Young Adult ,Orthopaedic haemophilia score ,Haemostasis - Abstract
Background - Physical activity in people with haemophilia (PWH) reduces the development of severe arthropathy, but it must be performed after regular, proper prophylaxis. Strict adherence to treatment is crucial to achieving effectiveness and established outcomes. The primary aim of this study was to collect prospective data on adherence to prophylaxis for over 36 months. A secondary aim was to verify whether adherence correlates with physical activity. Materials and methods - Italian patients with severe haemophilia A treated on prophylaxis with octocog alfa were included in the study. Physical findings were assessed by the Haemophilia and Exercise Project (HEP)-Test-Q and the Early Prophylaxis Immunologic Challenge (EPIC)-Norfolk Physical Activity Questionnaire; orthopaedic status was assessed by the Hemophilia Joint Health Score (HJHS). Adherence was measured as percentage of empty vials returned with respect to the prescribed amount. Results - Forty-two PWH were enrolled: 31% children, 21.4% adolescents, and 47.6% adults. Type, frequency and impact of physical activities differed among the three groups. The HEP-Test-Q showed the highest impairments in the domains "endurance" and "strength/co-ordination". Eight percent of patients were classified as adherent to prophylaxis. Among them, 50% had at least one bleeding episode in the year before enrolment; this percentage dropped during the three years of the study. While remaining stable in the "non-adherent" group, the HJHS score decreased in the "adherent" patients. The mean number of school/work days lost was lower in adherent patients (from 3.4±6.8 to 0.2±0.9) than in non-adherent ones. Discussion - PWH with better orthopaedic scores reported better physical performance. Adherence to long-term prophylaxis proved to be high and correlated with a reduction in bleeds, target joints, school/work days lost, and with a performance improvement in endurance sports activities over time.
- Published
- 2020
50. Development of a Process to Internationalize Occupational Programs in the Consumer and Hospitality Services Division.
- Author
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Advincula-Carpenter, Marietta M.
- Abstract
The purpose of a practicum project was to develop a process to internationalize occupational programs in the consumer and hospitality services division (CHSD). Five procedures were used to complete the project. First, a review of literature was conducted on how other colleges had internalized their courses. It included some research and practices done in the area of international education where disciplines have been internationalized. Second, a committee of experts was formed to discuss methods of internationalizing disciplines. It developed a draft of the process that included goals, objectives, an explanation of the concept, content, and flow chart of the process. Third, a summative committee reviewed the process for validation purposes. Fourth, the final and approved process was submitted to the dean of the CHSD. Appendixes include internationalizing curriculum models from the Milwaukee Area Technical College, and the Waukesha County Technical College internationalization strategic plan. Contains 20 references. (YLB)
- Published
- 1994
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