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3. Olfactory Function Assessment

Author

Valls-Mateus, Meritxell, Mariño-Sánchez, Franklin, Alobid, Isam, Marin, Concepció, Mullol, Joaquim, Zhang, Luo, editor, and Bachert, Claus, editor

Published
2022
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20. Reply

Author

Mullol, Joaquim, primary, Mariño, Franklin, additional, Valls, Meritxell, additional, Alobid, Isam, additional, and Marin, Concepció, additional

Published
2020
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28. Role of microRNAs in inflammatory upper airway diseases.

Author

Tubita, Valeria, Callejas‐Díaz, Borja, Roca‐Ferrer, Jordi, Marin, Concepció, Liu, Zheng, Wang, De Yun, and Mullol, Joaquim

Subjects
AIRWAY (Anatomy), NON-coding RNA, MICRORNA, NASAL polyps, B cells, PATHOGENESIS
Abstract

MicroRNAs (miRNAs) are a conserved family of small endogenous noncoding RNA molecules that modulate post‐transcriptional gene expression in physiological and pathological processes. miRNAs can silence target mRNAs through degradation or inhibition of translation, showing their pivotal role in the pathogenesis of many human diseases. miRNAs play a role in regulating immune functions and inflammation and are implicated in controlling the development and activation of T and B cells. Inflammatory chronic upper airway diseases, such as rhinitis and rhinosinusitis, are spread all over the world and characterized by an exaggerated inflammation involving a complex interaction between immune and resident cells. Until now and despite allergy, little is known about their etiology and the processes implicated in the immune response and tuning inflammation of these diseases. This review highlights the knowledge of the current literature about miRNAs in inflammatory chronic upper airways diseases and how this may be exploited in the development of new clinical and therapeutic strategies. [ABSTRACT FROM AUTHOR]

Published
2021
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33. Olfactory Training in Post-Traumatic Smell Impairment: Mild Improvement in Threshold Performances: Results from a Randomized Controlled Trial

Author

Langdon, Cristóbal, primary, Lehrer, Eduardo, additional, Berenguer, Joan, additional, Laxe, Sara, additional, Alobid, Isam, additional, Quintó, Llorenç, additional, Mariño-Sánchez, Franklin, additional, Bernabeu, Montserrat, additional, Marin, Concepció, additional, and Mullol, Joaquim, additional

Published
2018
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37. A model of increased impulsivity in rats with bilateral parkinsonism treated with Pramipexole

Author

Gago, Belén, Jimenez-Urbieta, Haritz, Marin, Concepció, Quiroga-Varela, Ana, Delgado-Alvarado, Manuel, and Rodriguez-Oroz, María Cruz

Subjects
Parkinson's disease, impulsivity, Parkinson, Enfermedad de
Abstract

Impulse control disorders (ICD) is a common side effect of the dopaminergic treatment in patients with Parkinson's disease, which is more associated with dopamine agonists than with levodopa. To understand its pathophysiology, reliable animal models are essential. Using the variable delay-to-signal (VDS) paradigm, impulsivity was evaluated in bilateral parkinsonian rats treated with pramipexole (PPX). In this test, rats have to introduce the snout into a nose poke that is signaled by a light (presented at variable delays) triggering the delivery of a food reward after a correct response. Reaching a stable baseline performance, a partial bilateral dopaminergic lesion with 6-OHDA was induced in the dorsolateral striatum (AP: +1mm, L: ±3.4mm, V:-4.7 mm, Bregma). Rats undertook the VDS test under 5 conditions: basal state, 6-OHDA-induced lesion, the effect of two doses of PPX (0,25mg/kg and 3mg/kg; Latin-square design), and the day after the last dose of PPX. Only the acute administration of 3 mg/kg of PPX significantly rised the number of premature responses, indicating an increase of impulsive behavior, in parkinsonian but not in sham rats. Both doses of PPX significantly decreased the accuracy of responding (correct/total number of responses) and increased the incorrect and perseverative (compulsive behavior) responses in both parkinsonian and sham treated groups when compared with saline-treated groups. In conclusion, PPX induced attention deficit (lack of accuracy) as well as compulsive behavior in control and parkinsonian rats, but increased impulsivity only in the parkinsonian animals. This model could constitute a valid tool to investigate the pathophysiology of ICD. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.

Published
2016

41. In vivo evaluation of the dopaminergic neurotransmission system using [123I]FP-CIT SPECT in 6-OHDA lesioned rats.

Author

Niñerola-Baizán, Aida, Rojas, Santiago, Bonastre, Mercè, Tudela, Raúl, Lomeña, Francisco, Pavía, Javier, Marin, Concepció, and Ros, Domènec

Abstract

The 6-hydroxydopamine (6-OHDA) rodent model of Parkinson's disease (PD) has been used to evaluate the nigrostriatal pathway. The aim of this work was to explore the relationship between the degree of 6-OHDA-induced dopaminergic degeneration and [123I]FP-CIT binding using single photon emission computed tomography (SPECT). Fourteen rats received a 6-OHDA injection (4 or 8 µg) into the left medial forebrain bundle. After 3 weeks, magnetic resonance imaging and scans with a small-animal SPECT system were performed. Finally, the nigrostriatal lesion was assessed by immunohistochemical analysis. Immunohistochemical analysis confirmed two levels of dopaminergic degeneration. Lesions induced by 6-OHDA diminished the ipsilateral [123I]FP-CIT binding by 61 and 76%, respectively. The decrease in tracer uptake between control and lesioned animals was statistically significant, as was the difference between the two 6-OHDA lesioned groups. Results concluded that [123I]FP-CIT SPECT is a useful technique to discriminate the degree of dopaminergic degeneration in a rat model of PD. Copyright © 2014 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2015
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