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This study's main objective is to present bibliometric data on articles related to digital educational environments (DEEs) published in the journals indexed in Scopus database between 2003 and February 2023. The data collected from 61 articles published within the study's scope were subjected to bibliometric analysis based on six categories: number of articles and citations, most cited articles, most used keywords, most influential countries, most-important institutions, and the most important journals. This study was designed as a descriptive study and offers bibliometric network maps of the most popular papers, keywords and countries, institutions, and journals. VOS viewer was used to create network diagrams and bibliometric analyses. The bibliometric analysis showed that the most frequently used keywords were digital learning environment(s), digital educational environment. The most prolific authors related to DEE are Antón-Sancho, Vergara, Barana, and Marchisio. The results showed that DEE studies were started in 2003 and the most articles were published in 2021. This study presents a global perspective on DEEs and proposes vision for future research.

One of the key challenges in achieving sustainable regional development is the effective utilization of labor potential within a territory. Major disparities in labor potential are observed across regions, driven by factors such as natural and climatic conditions, demographic trends, varying levels of industrial and transport infrastructure development, and government benefits. This issue is particularly pronounced in the Russian Arctic, a region of strategic importance to Russia. In the context of digital transformation, technological sovereignty, depopulation, and migration outflows, there exists a strong correlation between labor potential and workforce availability in these territories. The development of this macro-region necessitates a well-structured human resource strategy. This study aims to develop and test a methodology for forecasting labor potential levels in the context of digitalization and technological sovereignty, using data from regions within the Russian Arctic. The methodology comprises three stages: (1) identifying determinants and collecting relevant statistical data, (2) compiling a forecast data set based on dynamic series and calculating indices, and (3) utilizing a matrix framework to evaluate and rank territorial performance based on specified criteria. The study employs methods such as comparison, grouping, forecasting, visualization, and matrix techniques, as well as correlation and cluster analysis. Its scientific novelty lies in redefining the concept of “labor potential” within the framework of digitalization and technological sovereignty, and in creating a new typology of regions based on labor potential levels.

Pragmalinguistic analysis of media texts with a destructive component (violence, suicide, revenge, reprisals) is presented. A feature of the media content under study is: 1) the presence of a digital communicator – a digital platform (blog, messenger, social network, video, etc.) for broadcasting and replicating the communication process by the participants themselves (representatives of generation Z); 2) the place and role of a digital communicator in the implementation of a given destructive behavioral model. The transformation of axiosphere was revealed: there were axiological shifts in the conceptual field "LIFE-DEATH". Due to it we were able to identify the potential activity of the destructive vector of the homo digitalis behavioral model. The "axiologeme" is interpreted by us as a speech signal of hidden influence. In the text it acts as a lexical unit with code evaluation, which forms positive, neutral or negative associations: death (negative in psychological and emotional terms; neutral (logical conclusion of the life way) from the point of view of Christian morality in objective reality, neutral in virtual reality, as it is possible to reboot and positive (receiving bonuses: likes, discussions, comments). The development of influence plans ("positive-approving, neutral-indifferent or negativedisapproving") for the described events allowed us to identify the author's assessment of the media text with a destructive component. Positive-approving plan – 36.4%, negative-disapproving - 46.1%, and neutral-indifferent – 18.5%. These data reflect the prospects for the preservation/non-preservation of the axiosphere of Russian linguaculture.

Introduction. The World Health Organization considers the values of antibody titers in the hemagglutination inhibition assay as one of the most important criteria for assessing successful vaccination. Mathematical modeling of cross-immunity allows for identification on a real-time basis of new antigenic variants, which is of paramount importance for human health. Materials and methods. This study uses statistical methods and machine learning techniques from simple to complex: logistic regression model, random forest method, and gradient boosting. The calculations used the AAindex matrices in parallel to the Hamming distance. The calculations were carried out with different types and values of antigenic escape thresholds, on four data sets. The results were compared using common binary classification metrics. Results. Significant differentiation is shown depending on the data sets used. The best results were demonstrated by all three models for the forecast autumn season of 2022, which were preliminary trained on the February season of the same year (Auroc 0.934; 0.958; 0.956, respectively). The lowest results were obtained for the entire forecast year 2023, they were set up on data from two seasons of 2022 (Aucroc 0.614; 0.658; 0.775). The dependence of the results on the types of thresholds used and their values turned out to be insignificant. The additional use of AAindex matrices did not significantly improve the results of the models without introducing significant deterioration. Conclusion. More complex models show better results. When developing cross-immunity models, testing on a variety of data sets is important to make strong claims about their prognostic robustness.

For the sustainable development of territories, it is important to pay special attention to transport infrastructure, which directly affects the level of efficiency and competitiveness of the state (region) economy and forms the creation of a rational logistics system. Transport activates the work of the real sector of the economy (economic entities), carries out freight and passenger transportation, and is one of the significant sectors of the national economy, providing employment to the population, tax revenues to the budget system of the Russian Federation, investment attraction and GDP growth. The Arctic zone of the Russian Federation is strategically significant from the perspective of geopolitics and geo-economics in the modern world (1215% of the country’s GDP, 25% of exports). In the article, the object of study is the Western and Central Arctic of the Russian Federation, including six of the eight subjects belonging to the Arctic territories. The methodological framework of the study is based on review and analysis of regulatory documents and scientific literature that determine trends and prospects for improving territories within the development of transport infrastructure. The information base is regional statistical information. The study and assessment of the level of transport infrastructure development of the studied region is carried out. Economic analysis is conducted using statistical methods that allow identifying the main reasons associated with the ineffective operation of transport infrastructure at the meso-level. Tables and figures are used to visualize the research results. This makes it possible to conduct a comparative analysis of territories by the level of transport infrastructure development, to identify leaders and outsiders to substantiate proposals for stimulating key areas, basing on the review of regulatory documents aimed at increasing the efficiency of functioning of this area.

At the 15th Congress of Anthropologists and Ethnologists of Russia, held in St. Petersburg at the end of June 2023, special attention was paid to the discussion of topical theoretical and practical problems related to scientific reflections and social practices of the institute of mentoring in the cultures of the Rus-sian North. The report presented by the authors of this article at the Congress outlined the scientific results of research on the traditional institution of mentoring in the Old Believer societies of Karelians, Komi, Russian Ust-Tsilems, the “institute of grandmothers” in Kenozerye and Onega Pomorie, the ritual “mentoring” functions of Nenets shamans and Zyryan sorcerers, public practices of the spiritual guidance of the laity in the parochial community of the North Russian mir-zemstvo. The central place in the article is given to the presentation of the scientific results of the analysis of the forms, methods and directions of the mentoring activities of the Kenozerskiy National Park, which, relying on the ethno-cultural heritage of the traditional societies of the Ozernyy district, acts as a reference methodological school-laboratory, implementing a wide range of mentoring research and educational practices aimed at transformation of local territories into a socio-cultural space of creative dialogue and cooperation between the Park and local communities, training of leaders and activists of territorial public self-government (TPS), elaboration of regional strategy and local programs of spatial development of the Northern macro-region.

Immunotherapy represents a groundbreaking therapeutic approach, based on the immune system’s intrinsic capacity to interfere with tumor progression, that opens the horizons in the treatment of endometrial cancer. However, the clinical efficacy of immunotherapy is hampered by the development of resistance in patients. The resistance to immunotherapy is multifactorial mechanism, encompassed genetic and epigenetic alterations in tumor cells modulating immune checkpoint molecules, resulted in escaping immune surveillance. The tumor microenvironment can orchestrate an immunosuppressive milieu, attenuating the immune response and facilitating tumor progression. To overcome immunotherapeutic resistance in endometrial cancer we must bring to light the mechanisms of intricate interplay between neoplastic cells, the host immune system, and the tumor microenvironment. The identification of predictive biomarkers for immunotherapeutic response and the innovative agents capable of reversing resistance pathways must be developed. Our review summarizes accumulated data on the role of cells of the tumor microenvironment and their regulatory molecules in the mechanisms underlying therapeutic effects of immune checkpoint inhibitors, including resistance to therapy. Major question we raise here – which group of patients is the most favorable to achieve durable immunotherapy response in endometrial cancer?

IntroductionAggression and self-harm disproportionately occur in youths preoccupied with social status tracking. These pathological conditions are linked to a serotonin (5-HT) deficit in the brain. Ablation of 5-HT biosynthesis by tryptophan hydroxylase 2 knockout (TPH2-KO) increases aggression in rodents. Remarkably, deletion of the trace amine-associated receptor 1 (TAAR1) results in the same consequences. Unlike the nuanced dynamics of social status cues in young people, the social ranks of rats mainly advance when they dominate larger opponents in combat.MethodsThis study explored whether the potent TAAR1 agonist RO5263397 reduces aggression caused by 5-HT depletion, and whether social rank advancement motivates this aggression. The resident-intruder paradigm was applied with larger and smaller intruders to evaluate whether social rank advancement motivates aggressive behaviors in TPH2-KO rats.ResultsWhen a smaller intruder was introduced, 5-HT-deficient rats did not differ from wild type littermates. However, when the intruders were larger, the mutants extended their aggressive efforts, refusing to submit. Importantly, RO5263397 selectively abolished this abnormal form of aggression in TPH2-KO rats.DiscussionResults supported social rank advancement as the main incentive. These data also suggest that TAAR1 is a promising target for the development of new treatments for aggression; independent data also support this conclusion.

Background. The process of storing sperm in a deeply frozen state causes structural and functional disorders of spermatozoa, which reduces their fertilizing ability. The main mechanism of the negative effect of cryopreservation on spermatozoa is the development of oxidative stress. Molecular hydrogen has some advantages as a potential antioxidant molecule - it is a selective effect on certain reactive oxygen species, the ability to overcome cell membranes, the absence of toxic effects. Purpose. To study the effect of molecular hydrogen on the functional status of native and deconserved sperm cells of breeding bulls. Materials and methods. The object of the study was the ejaculates of bulls before cryopreservation and after defrosting. The native sperm diluted with the "BioXcell" diluent, the native sperm diluted with the "BioXcell" diluent enriched with molecular hydrogen, the sperm after deep freezing and the sperm after deep freezing pretreated with molecular hydrogen were studied. The intensity of free radical processes and the activity of antioxidant enzymes were determined in spermatozoa. Results. After cryopreservation of sperm, the processes of lipid peroxidation in spermatozoa are significantly activated. The content of malondialdehyde, diene and triene conjugates increases. The use of molecular hydrogen to correct the quality of sperm production after cryopreservation gave positive results. A decrease in the concentration of primary and intermediate products of lipid peroxidation was noted. The activity of superoxide dismutase and catalase in spermatozoa significantly increases. Conclusion. Molecular hydrogen has the potential as a new and effective antioxidant, the widespread use of which is possible for veterinary purposes. Sponsorship information. The study was funded by the Russian Science Foundation grant No. 23-26-00205.

Introduction. This paper is devoted to identifying the role of family and children in the value system of Kaliningrad university students. This aspect is important both in connection with the current demographic situation, as well as with the decision to declare 2024 the Year of the Family in Russia. Materials and methods. In 2023, a survey was conducted among students of Kaliningrad universities, which was attended by 241 people aged 18-24 years. The questionnaire consisted of six “open” questions. Students were asked to give their own definition of the concept of “values”; to name the most significant values; to describe the ideal family model; to determine the role of children in general and in their own life strategies; to explain the reasons for wanting or not wanting to have children. This type of survey was designated as an express interview. The methodological basis of the study was the concept of demographic well-being, according to which demographic processes must be considered simultaneously at the macro and micro levels. In this research, the focus was on the micro level. Results. The study revealed that the majority of respondents perceive values as basic attitudes that define a person’s life, are expressed in spiritual and material things and are passed on to the next generations. The most important values are recognized as family, friendship, money, love, freedom and health. Talking about the ideal family, the survey participants described the relationships they would like to see in the family. Only a few people consider the ideal families in which they grew up and live. The majority of respondents intend to have children in the future, although some make a reservation that there must be appropriate conditions for this. At the same time, a significant proportion of young people were identified who expressed a fundamental reluctance to have children. Discussion. Based on the conducted research, it was revealed that the family is the most significant category in the students’ value system. The ideal is a complete family without financial problems, whose members live in an environment of mutual understanding, support and love. For most respondents, children seem to be a necessary part of the family. Some survey participants expressed unwillingness to perform parental functions. The conducted research has demonstrated the importance of analyzing demographic processes at the micro level, that is, from a human perspective, taking into account his values and life attitudes.

Animal behavior can serve as an important indicator of welfare for zoo inhabitants. The maternal behaviors exhibited by lynx and puma in captivity are crucial not only for the survival and well-being of their cubs but also provide valuable insights for species conservation programs. We analyzed the motor activity of a male and female Siberian lynx and a male and female puma during the period when they were raising their kittens, which had not yet left the shelter at the time of observation. Our ethological monitoring revealed both similarities and differences in behavior across species and sexes. We found that males of both species exhibited passive behaviors more frequently than females. Overall motor activity was higher during the evening observation periods. Notably, the male lynx spent significantly less time in the shelter compared to the other studied animals, likely due to his close cohabitation with the female and their kittens. In contrast, the male puma was kept nearby but separately from the female and her offspring. Abnormal behaviors were observed in nearly all animals, except for the female lynx. The female puma exhibited the highest level of abnormal activity, frequently carrying her kitten in her mouth for extended periods, which suggests a high level of stress. The intraspecific Shorygin indices of behavioral similarity between male and female lynxes and pumas were relatively low, at 42% and 45%, respectively. In comparison, our previous research indicated that the behavioral similarity index between male and female Eurasian lynxes without offspring was 87%. This suggests that the presence of kittens significantly increases the differences in time budgets between males and females.

Background. Intensive milk production technology creates a number of factors that can put an animal into a state of technological stress. The effect of stress is reflected in nonspecific resistance, which represents the body's ability to resist the effects of adverse factors by maintaining protective forces at the proper level. Neutrophils are one of the first protective cellular barriers that are rapidly mobilized when exposed to stress factors. To decipher the changes taking place in response to the action of stressors, the involvement of various evaluation tools is required. One of the possible methodological approaches is the use of various visualization methods that provide access to spatio-temporal information at the level of individual organelles and Purpose. The study of the morpho-functional state of neutrophils under technological stress in cattle by laser interference and electron scanning microscopy. Materials and methods. The work was carried out on 30 clinically healthy highly productive black-and-white cows. A combination of impacts was considered as technological stress: the rearrangement of animals and the change of service personnel. Neutrophils were analyzed by laser interference and electron scanning microscopy. Results. A change in the morphological structure and functional activity of neutrophils after the action of technological stress is shown. The analysis of interferograms revealed an increase in the heterogeneity of neutrophils due to the appearance of degeneratively altered cell forms with an increase in the number of functionally active neutrophils. Electron scanning microscopy revealed the appearance of NEToses and neutrophils with emptied granules and vacuolization of the cytoplasm after technological stress. Conclusion. The revealed morphofunctional changes in neutrophils prove the strain of adaptation mechanisms under technological stress. This circumstance must be taken into account in order to prevent disruption of the adaptive capabilities of the organism of highly productive animals.

Relevance. Studies on model systems have confirmed the effectiveness of antisense oligonucleotides, including those that contain photoactive groups, for the modification of nucleic acids. However, this strategy has not yet found wide application due to the lack of successful methods for the cellular delivery. The development of effective preparations capable of acting on target nucleic acids in cells is an urgent task. The objective of the work is to create nanocomposites consisting of TiO2 nanoparticles, antisense oligonucleotides, and photoactive groups and to study their effect on target nucleic acids by the example of inhibition of influenza A virus replication in the cellular system. Materials and methods. Influenza virus A/Aichi/2/68 (A/H3N2), N-succinimide ether of p-azidotetrafluorobenzoic acid, TiO2 nanoparticles, and oligodeoxyribonucleotides have been used in the work. The antiviral activity of the proposed nanocomposites has been studied on the MDCK cells infected with the A/H3N2 virus. Results and discussion. Unique nanocomposites have been created, which consist of three functional components, i.e., titanium dioxide nanoparticles, antisense oligonucleotides, and the photoactive tetrafluoroarylazide group, respectively, providing penetration into cells, selective interaction with target nucleic acids, and photomodification of the targets. A significant antiviral site-specific action of the nanocomposites has been demonstrated against the influenza A virus in the cellular system, which exceeds the effect of the analogous samples that contain no photoactive groups. Conclusion. The biological activity of the created nanocomposites has been demonstrated by the example of highly effective suppression of influenza A virus replication in the cellular system. The results indicate the prospects of using the proposed drugs to affect target nucleic acids inside cells.

Introduction. The COVID-19 pandemic, etiologically related to SARS-CoV-2, was the longest-lasting pandemic for an acute respiratory disease and had a significant impact on demography, economics and politics globally. Experiences with this pandemic are significant for the sustainable development of human society. A detailed analysis of these experiences in epidemic control should include details of the pathogen evolution down to the regional level. The aim of the study was to establish the regularities of the COVID-19 epidemic process in connection with the change of the pathogen genetic variants on the territory of Primorsky Krai. Materials and methods. A retrospective epidemiological analysis of COVID-19 incidence and dynamics of circulation of SARS-CoV-2 genetic variants during the pandemic of this disease (11.03.2020–05.05.2023) in Primorsky Krai was carried out. Data was gathered from the Department of Rospotrebnadzor in Primorsky Krai, the Centre of Hygiene and Epidemiology in Primorsky Krai, as well as the G.P. Somov Research Institute of Epidemiology and Microbiology of the Russian Federation and Russian Platform for Aggregation of Information on Virus Genomes (VGARus). In particular, 1055 nucleotide sequences of full-length SARS-CoV-2 genomes from Primorsky Krai, among which 553 were sequenced at the G.P. Somov Research Institute of Epidemiology and Microbiology were included in analysis. Results. When analyzing the epidemic dynamics of COVID-19 in Primorsky Krai (2020–2023), 7 rises in incidence with different clinical and epidemiological symptoms depending on the genetic variants of the pathogen were identified. At the beginning of the pandemic in Primorsky Krai, as well as throughout Russia, Wuhan-like variants of SARS-CoV-2 were predominant, though later, Delta and Omicron genetic variants were in the majority. By the end of April — beginning of May 2023, the proportion of Omicron sub-variants (XBB.1.9.2 and XBB.1.16) in Primorsky Krai was higher than the Russian average and comparable to that in neighboring countries (Republic of Korea and Japan). Conclusion. Due to the ongoing evolution of SARS-CoV-2, the possibility of the emergence of new pathogens, the peculiarities of the geographical location as well as political and economic importance of Primorsky Krai, it is necessary to consistently improve regional capabilities for operational molecular virological monitoring.

Historical education in the system of higher educations is designed to solve not only teaching, but also upbringing tasks. Therefore, it is called upon to quickly and effectively overcome challenges which the historical education faces with the help of a specific political situation and social need. The modern situation is particularly acute in this regard. The concept of teaching Russian history to individuals of non-historical specialties and fields, which are implemented in higher education organisations, adopted in 2023, also testifies to this. The renewal of the content of historical education in the country requires the introduction of innovations in the field of the methodology of teaching. The methodological basis of history teaching in Russia has a long tradition, formed within the framework of several directions. Modern researchers of the problem note the special importance of the technological approach, which has become widespread in educational institutions of the country. However, it is not enough for today. The methodology of teaching history should precisely reflect the changes in the content of the discipline. At the same time, the range of methodological techniques in the teacher's arsenal may not change significantly. It is even possible to appeal to the experience of pre-revolutionary and Soviet methodology. But the question of the content of the methodological base and its objective orientation is core.

The study is focused on revealing and analysis of external influences that affect the process of teaching the Russian language for specific purposes - business/professional communication to bilingual learners. The analysis is correlated with the description of external factors that cause a shift of emphasis from teaching the language of profession to teaching business communication. This comprehensive analysis makes it possible to build a uniform teaching course model based on a holistic approach. The study defines the general strategy of training, formulates tasks and outlines approaches to their solution, as well as delineates the contours of a branched out multi-component practical training course.

Combination steam ovens, or combi steamers, have entered all spheres of food production, including the meat industry. Their rational use requires a scientific and practical foundation. This research featured the changes in mean volume temperature and temperature gradient that occur in meat products (one-dimensional bodies with different nutrient compositions) during heat treatment in dry air and a steam-air mix. The research involved two samples of meat products with different moisture and fat contents. The chicken fillet sample had a moisture content of 74.5% and a fat content of 1.9% while the pork shoulder sample had a moisture content of 55.1% and a fat content of 29.4%. Shaped as a one-dimensional cylinder and a plate, the samples were subjected to heating at the temperature range of 160–240°C in a Unox-203G steam-convection oven (Italy). Dry air and a steam-air mix with a humidity of 80–85% served as a heating medium. The temperature was measured using thermocouples attached to a Sosna-004 meter. The research revealed some patterns in the mean volume temperature and temperature gradient. The temperature gradient involved three stages during processing in a steam-air mix and four stages when treated with dry air. The change in the mean volume temperature for the steam-air mix could be described by a power law equation; the dry air treatment was described using a linear equation. When heated in dry air, the rate of change in the temperature gradient was constant at first but started to decrease at a certain stage. The change rate in the mean volume temperature remained low for 5 min and started to increase onwards, maintaining its value until the end of the process. When heated in a steam-air mix, the change rate in the temperature gradient dropped to its minimum in 4–5 min and started to grow. The mean volume temperature demonstrated a high change rate during the first 5 min and went down. The chicken fillet with its low fat content warmed up faster by 13–26% when processed in a steam-air mix and by 9–23% when treated in dry air. The plate-shaped products needed longer heat treatment. The composition and form had no significant effect on the nature of the change in the temperature gradient and mean volume temperature. The obtained dependencies made it possible to select the optimal temperature and humidity conditions for convective frying of meat products.

The article discusses information security in the system of an industrial enterprise. Attention is focused on the need to implement a continuous information security process to protect all information assets from leaks, theft and unauthorized disclosure, the main provisions of information security management standards are analyzed. Objective: To optimize the methods of software protection of modern industrial enterprises, as well as to reduce threats and vulnerabilities related to information security at enterprises. Method or methodology of the work: In the process of investigating the problem, analytical methods of analysis were used. Results: The need to use ISO/IEC 27001 standards and the PDCA (Plan-Do-Check-Act) model at industrial enterprises of high-tech sectors of the economy in order to reduce threats and losses of information security, identify critical factors that negatively affect business processes and the enterprises themselves. Practical implications: The results obtained can be used as a theoretical basis for existing assessments of information security tools and automated security systems at high-tech industrial enterprises in modern economic conditions.

Abstract Low‐grade epilepsy‐associated tumors (LEATs) are a common cause of drug‐resistant epilepsy in children. Herein, we demonstrate the feasibility of using tumor tissue derived from stereoelectroencephalography (sEEG) electrodes upon removal to molecularly characterize tumors and aid in diagnosis. An 18‐year‐old male with focal epilepsy and MRI suggestive of a dysembryoplastic neuroepithelial tumor (DNET) in the left posterior temporal lobe underwent implantation of seven peri‐tumoral sEEG electrodes for peri‐operative language mapping and demarcation of the peri‐tumoral ictal zone prior to DNET resection. Using electrodes that passed through tumor tissue, we show successful isolation of tumor DNA and subsequent analysis using standard methods for tumor classification by DNA, including Glioseq targeted sequencing and DNA methylation array analysis. This study provides preliminary evidence for the feasibility of molecular diagnosis of LEATs or other lesions using a minimally invasive method with microscopic tissue volumes. The implications of sEEG electrodes in tumor characterization are broad but would aid in diagnosis and subsequent targeted therapeutic strategies.

One of the most important features of professional activity is the ability to build a dialogue, organize business communication. The possession of communicative competencies provides the student with the opportunity to quickly achieve their goals through the implementation of speech turnovers and constructions that comply with the principles and standards of speech etiquette, affecting the establishment and maintenance of the psychological climate in the process of interaction. The purpose of the article is to review the experience of forming communicative competencies with the help of practice-oriented technologies. Requirements for the formation of communicative competencies are reflected in regulatory documents. The competencies under consideration represent the student's ability to build productive professional interaction using various communication methods. We reveal the motivational, cognitive, and active components of communicative competencies, reflecting the desire for interpersonal communication and support for established interaction, the student's understanding of the value of communicative competencies in future professional activities, and the ability to organize effective cooperation. Practice-oriented technologies, including case studies and design, contribute to solving professional problems through group discussions and situation analysis. The study revealed the impact of practice-oriented technologies implemented in higher education institutions on the formation of students' communicative competence.

The purpose of the work is to consider the possibilities of time trackers in the design activities of students. The article presents an analysis of modern time trackers that contribute to the selforganization of students to achieve educational goals. In the context of an increase in the share of independent training in universities and the expansion of distance learning, there is a need for students to master time management, which allows them to conduct activities most productively. Time management involves the use of electronic tools that promote the development of the discipline, self-organization and student planning for the rapid achievement of goals. The article discusses both trackers for large-scale professional activities, control and accounting of working hours, as well as simpler versions of trackers suitable for personal use by students. Time management ensures timely implementation of the project, allows you to evaluate the contribution of each student to the work, and adjust the activities of students. The use of time trackers in performing various tasks, including the implementation of projects, contributes to high-quality visualization of the number of hours spent on the task and, as a result, the development of discipline and self-organization of students.

The organization of the educational process should be carried out taking into account the epidemiological situation and following the requirements that are due to quarantine measures. The leadership of vocational schools is looking for ways to conduct classes in a safe environment, assessing the potential risks for teachers and students. Higher schools implement the possibilities of electronic technologies as a factor in ensuring the safety of subjects of the educational process for communication between students and teachers at a distance. The purpose of the article is to review the experience of organizing virtual interaction between students and teachers within the framework of e-learning during the spread of coronavirus infection. The article reveals the possibilities of electronic technologies that allow communicating at a remote distance. The preparation of students in critical conditions is carried out using various electronic means that promote active interaction. The results of the study reflect the opinion of students of higher educational institutions about the use of virtual interaction tools. The results obtained using the Likert scale allow us to say that the majority of the respondents are active participants in virtual interaction and are ready to continue to communicate using the presented means despite the existing difficulties.

The use of information technology in teaching humanitarian disciplines contributes to the formation of highly qualified, competitive specialists who can adapt to rapidly changing conditions, possessing a high level of development of critical and creative thinking, ready for professional self-development and self-improvement, for the implementation of reflection, capable of setting goals and systematically achieving them. The work actualizes the importance of information technology in the training of highly qualified competitive specialists capable of implementing professional activities at a high level. The purpose of the article is to analyze the experience of implementing information technologies in teaching humanitarian disciplines. Smart boards, multimedia installations, document cameras, electronic textbooks, electronic educational platforms and others were used as information technologies used in the teaching of the humanities. The study made it possible to reveal the influence of information technologies on the level of formation of students' competencies.

Background. Improving the quality of dental care for patients with sensorineural hearing loss is one of the most important problems in dentistry at present. The special status of patients with sensorineural hearing loss makes this contingent the most defenseless in such an issue as dental education. In this regard, these patients have an unsatisfactory level of hygienic dental knowledge. In addition, they have low motivation to improve their level of knowledge, and also lack motivation to not only maintain, but also strengthen their oral health. Regular and proper oral hygiene ensures 85-90% of dental health. The purpose of the research is to study the effectiveness of using a modern, adapted, proposed by us, method of brushing teeth in patients with sensorineural hearing loss. Materials and methods. To study the effectiveness of our proposed method of brushing teeth, 150 people with varying degrees of hearing loss were selected. A study of dental status was carried out, a questionnaire was carried out, an index assessment of hard dental tissues was carried out, a modern, adapted method of brushing teeth was tested. Results. When analyzing this method of brushing teeth, it was revealed that for patients with sensorineural hearing loss, it is not so much the amount of information that is important, but the amount of information learned with the possibility of its correct implementation in practice. Conclusions. Our research has shown that the adapted method of brushing teeth makes it possible to easily remember information and control the quality of teeth brushing at each stage.

Introduction. Early diagnosis and treatment improve clinical outcomes, especially in chronic arthritis (CA) and systemic connective tissue disorders (SCTD). Thanks to clinical research from the 1990s on and innovative drugs, 55 million life-years have been saved. The COVID-19 pandemic brought on medical challenges in rheumathology. Objective. The study objective was to research early diagnosis, time of the introduction of innovative therapy, participation in clinical research, influence of gender, age, and corticosteroid treatment on hospitalization rate due to COVID-19 infection in CA and SCTD patients. Method. In November 2022 we performed the crosssectional study in CA and/or SCTD patients using an online questionnaire. The first part of the analyzed questions referred to sociodemographic characteristics and data concerning rheumatic disease - rheumatoid arthritis (RA) and other rheumatic diseases. The second part referred to COVID-19. Data were analyzed by descriptive statistics and Pearson's Chi-square test using SPSS 29. Results. Out of the total of 176 participants, RA was present in 60,8%. The time from the symptom onset to diagnosis was longer than two years. RA was more frequently diagnosed in the first six months (p < 0,05 - males). The innovative therapy was used by 59,7% of the participants. The majority of RA patients got innovative therapy after five years from disease onset, which is later than in other CAs (p < 0,05 - females). There were 23,3% of the participants who took part in clinical research, more those with RA (p < 0,05 - females). Corticosteroid therapy influenced a higher rate of hospitalization during COVID-19 infection (p < 0,05 - females). Conclusion. Males suffering from RA were diagnosed sooner, while females with RA participated more in clinical research but were later introduced to innovative therapy. The use of glucocorticoid therapy in the treatment of CA and SCTD increased the risk of hospitalization due to COVID-19 infection.

The impact of nano-selenium supplementation on lipid metabolism, liver enzymes, renal function, and protein levels in male lambs was investigated in this study during a 60-day period. Lambs were divided into two groups - control and experimental, which were administered nanoselenium orally at a dosage of 0.5 mg/ kg of feed once a day, daily. Each group consisted of five male lambs. According to the findings, cholesterol levels dropped significantly at days 45 (P 0.01) and 60 (P 0.05), whereas triglyceride levels significantly rose at days 15 and 30 (P 0.01). Throughout the trial, the levels of uric acid and creatinine were constant. At days 15 and 60, aspartate aminotransferase (AST) levels were significantly decreased (P 0.05), while at days 45 and 60, alkaline phosphatase (ALP) levels declined (P 0.01 and P 0.05, respectively). At days 15 and 30, albumin levels dropped significantly (0.05), but day 60 saw an increase in globulin levels significantly (P 0.05). The drop in AST and ALP levels might be a sign that liver function has possibly improved. However, the drop in albumin levels and rise in globulin levels raise the possibility that taking nano-selenium supplements may affect how proteins are metabolized. The findings of this study concluded that the effects of nano-selenium supplementation on lipid metabolism, liver enzymes, renal function, and protein levels in male lambs were time-dependent. In addition to possible improvements in liver function based on decreased AST and ALP levels and changes in albumin and globulin levels, the study also noticed an initial transient increase in triglyceride levels that was followed by a decline in cholesterol levels. To determine the time-dependent changes in liver function, liver enzymes, as well as renal function in response to nano-selenium supplementation in male lambs was objective of this study.

The study is devoted to the study of the relationship between the structure of the economy and the level of pollution of European cities in the context of the environmental imperative. Based on comparative statistical analysis, the level of pollution in European cities in 2013 and 2023 was considered and cities with the most and least favorable environmental situation were defined. Studied cities were divided into 7 groups by pollution index; stable trend of their location was determined through carrying out a cartographic analysis: groups of the most polluted cities are located mainly in the southeast of Europe and the least - in the northwest. Five types of cities with different trends in pollution index dynamics were identified. Based on a comprehensive synthetic analysis of cities with maximum improvement and deterioration of the environmental situation, the main factors of multidirectional dynamics are described - activity of environmental policy, sectoral structure transformation of urban economy. Main spatial trends in the environmental situation of European cities were identified: cities with positive dynamics of pollution index predominantly concentrated in the southeast, with a negative - in the east. The analysis showed that 2/3 of the largest cities in Europe improved their ecological condition mainly due to the effectiveness of environmental measures, the green political movement, the development of the tertiary and quaternary sectors in their economy.