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2 results on '"Marina Punturieri"'

1. Immunophenotypic heterogeneity of bone marrow-derived mesenchymal stromal cells from patients with hematological disorders: correlation with bone marrow microenvironment

Author

Diana, Campioni, Sabrina, Moretti, Luisa, Ferrari, Marina, Punturieri, Gian Luigi, Castoldi, and Francesco, Lanza

Subjects
Adult, hematological disorders, bone marrow, Bone Marrow Cells, Environment, Middle Aged, Hematologic Diseases, immunophenotype, Immunophenotyping, NO, mesenchymal stromal cells, Humans, Stromal Cells, Cells, Cultured, Aged
Abstract

The immunophenotypic analysis of ex vivo-expanded mesenchymal stromal cells (MSC) has so far been confined to single or dual staining analysis in normal subjects. In this study, using a four-color cytofluorimetric protocol, we demonstrated that cultured MSC derived from the bone marrow of patients with hematologic malignancies showed alterations in the expression of CD105, CD90, CD184, and HLA-DR molecules. The decrease in the percentage of CD105+ and CD90+ MSC correlated with an increased bone marrow angiogenesis. This paper provides evidence that multiparametric flow cytometry is essential for the establishment of a standardized protocol to identify various MSCs subsets and aberrant phenotypes.

Published
2006

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