1. Increased risk of ADHD in families with ASD
- Author
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Manuel Bouvard, Hugo Peyre, Marion Leboyer, Richard Delorme, Céline Bouquet, Garry D. Honey, Anita Beggiato, Isabelle Scheid, Myriam Ly-Le Moal, Thomas Bourgeron, Marion Poumeyreau, Frédérique Amsellem, Anouck Amestoy, Federico Bolognani, Anna Maruani, Mathilde Septier, Alexandru Gaman, Psychiatrie de l'enfant et de l'adolescent [Robert-Debré], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré, Centre de Psychiatrie et Neurosciences (U894), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Diderot - Paris 7 (UPD7), Laboratoire de sciences cognitives et psycholinguistique (LSCP), Département d'Etudes Cognitives - ENS Paris (DEC), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École des hautes études en sciences sociales (EHESS)-Centre National de la Recherche Scientifique (CNRS), Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions (GHFC (UMR_3571 / U-Pasteur_1)), Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Centre hospitalier Charles Perrens [Bordeaux], Fondation FondaMental [Créteil], Roche Innovation Center [Basel, Switzerland], Institut ROCHE [Boulogne-Billancourt], Roche S.A.S, IMRB - 'Neuropsychiatrie translationnelle' [Créteil] (U955 Inserm - UPEC), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), and The Institut Pasteur, INSERM, Fondation FondaMental, APHP, DHU Protect, Labex BioPsy and Fondation Orange supported this work
- Subjects
Adult ,Male ,Parents ,Proband ,medicine.medical_specialty ,Adolescent ,Autism Spectrum Disorder ,behavioral disciplines and activities ,Gee ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,mental disorders ,Developmental and Educational Psychology ,medicine ,Child and adolescent psychiatry ,Humans ,Attention deficit hyperactivity disorder ,Family ,Genetic Predisposition to Disease ,0501 psychology and cognitive sciences ,Sibling ,Child ,business.industry ,Siblings ,05 social sciences ,Family aggregation ,General Medicine ,Middle Aged ,medicine.disease ,030227 psychiatry ,Psychiatry and Mental health ,[SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics ,Attention Deficit Disorder with Hyperactivity ,Autism spectrum disorder ,Case-Control Studies ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Autism ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Female ,business ,050104 developmental & child psychology ,Clinical psychology - Abstract
Attention Deficit and Hyperactive Disorder (ADHD) and Autism Spectrum Disorders (ASD) are frequent comorbid neurodevelopmental conditions and the overlap between both disorders remains to be delineated. A more complete understanding of the shared genetic and environmental factors is needed. Using a family-based method, we evaluated the risk of ADHD in a group of relatives with an ASD proband (ASD-) and a group of relatives with an ASD and ADHD proband (ASD+). We enrolled 1245 individuals in the study: 499 probands, their 746 first-degree relatives and 140 controls. We used a multivariate generalized estimating equation (GEE) model, in which the dependent variable was the ADHD diagnosis in the relatives and the independent variable the ASD+ or ASD- in probands. We adjusted for sociodemographic factors (age, sex, IQ) and for the nature of the familial relationship with the affected proband (parent or sibling). Among the probands, there were 287 ASD- and 212 ASD+ individuals. ADHD was more frequent in relatives (19%) than in the control group (7%) (p = 0.001). The risk of ADHD was higher in the ASD+ relatives group than in the ASD- relatives group (GEE model OR 1.58 [95% CI 1.04-2.38], p = 0.032). This result was found in parents (OR 1.96 [95% CI 1.14-3.36], but not in siblings (OR 1.28 [95% CI 0.84-1.94], p = 0.434). Our study provides a representative estimate of the family distribution of ADHD in relatives of ASD probands but supports the modest effect of shared genetic and environmental factors between both disorders.
- Published
- 2018