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2. Intrinsic limits on resolutions in muon- and electron-neutrino charged-current events in the KM3NeT/ORCA detector

Author

Adrián-Martínez, S., Ageron, M., Aiello, S., Albert, A., Ameli, F., Anassontzis, E. G., Andre, M., Androulakis, G., Anghinolfi, M., Anton, G., Ardid, M., Avgitas, T., Barbarino, G., Barbarito, E., Baret, B., Barrios-Martí, J., Belias, A., Berbee, E., Berg, A. van den, Bertin, V., Beurthey, S., van Beveren, V., Beverini, N., Biagi, S., Biagioni, A., Billault, M., Bondì, M., Bormuth, R., Bouhadef, B., Bourlis, G., Bourret, S., Boutonnet, C., Bouwhuis, M., Bozza, C., Bruijn, R., Brunner, J., Buis, E., Buompane, R., Busto, J., Cacopardo, G., Caillat, L., Calamai, M., Calvo, D., Capone, A., Caramete, L., Cecchini, S., Celli, S., Champion, C., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Classen, L., Cobas, D., Cocimano, R., Coelho, J. A. B., Coleiro, A., Colonges, S., Coniglione, R., Cordelli, M., Cosquer, A., Coyle, P., Creusot, A., Cuttone, G., D'Amato, C., D'Amico, A., D'Onofrio, A., De Bonis, G., De Sio, C., Di Palma, I., Díaz, A. F., Distefano, C., Donzaud, C., Dornic, D., Dorosti-Hasankiadeh, Q., Drakopoulou, E., Drouhin, D., Durocher, M., Eberl, T., Eichie, S., van Eijk, D., Bojaddaini, I. El, Elsaesser, D., Enzenhöfer, A., Favaro, M., Fermani, P., Ferrara, G., Frascadore, G., Fusco, L. A., Gal, T., Galatà, S., Garufi, F., Gay, P., Gebyehu, M., Giacomini, F., Gialanella, L., Giordano, V., Gizani, N., Gracia, R., Graf, K., Grégoire, T., Grella, G., Grmek, A., Habel, R., Hallmann, S., van Haren, H., Harissopulos, S., Heid, T., Heijboer, A., Heine, E., Henry, S., Hernández-Rey, J. J., Hevinga, M., Hofestädt, J., Hugon, C. M. F., Illuminati, G., James, C. W., Jansweijer, P., Jongen, M., de Jong, M., Kadler, M., Kalekin, O., Kappes, A., Katz, U. F., Keller, P., Kieft, G., Kießling, D., Koffeman, E. N., Kooijman, P., Kouchner, A., Kreter, M., Kulikovskiy, V., Lahmann, R., Lamare, P., Larosa, G., Leisos, A., Leone, F., Leonora, E., Clark, M. Lindsey, Liolios, A., Alvarez, C. D. Llorens, Presti, D. Lo, Löhner, H., Lonardo, A., Lotze, M., Loucatos, S., Maccioni, E., Mannheim, K., Manzali, M., Margiotta, A., Marinelli, A., Mariş, O., Markou, C., Martínez-Mora, J. A., Martini, A., Marzaioli, F., Mele, R., Melis, K. W., Michael, T., Migliozzi, P., Migneco, E., Mijakowski, P., Miraglia, A., Mollo, C. M., Mongelli, M., Morganti, M., Moussa, A., Musico, P., Musumeci, M., Navas, S., Nicolau, C. A., Olcina, I., Olivetto, C., Orlando, A., Orzelli, A., Papaikonomou, A., Papaleo, R., Păvălaş, G. E., Peek, H., Pellegrini, G., Pellegrino, C., Perrina, C., Pfutzner, M., Piattelli, P., Pikounis, K., Pleinert, M. -O., Poma, G. E., Popa, V., Pradier, T., Pratolongo, F., Pühlhofer, G., Pulvirenti, S., Quinn, L., Racca, C., Raffaelli, F., Randazzo, N., Rauch, T., Real, D., Resvanis, L., Reubelt, J., Riccobene, G., Rossi, C., Rovelli, A., Saldaña, M., Salvadori, I., Samtleben, D. F. E., García, A. Sánchez, Losa, A. Sánchez, Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schimmel, F., Schmelling, J., Schnabel, J., Sciacca, V., Sedita, M., Seitz, T., Sgura, I., Simeone, F., Sipala, V., Spisso, B., Spurio, M., Stavropoulos, G., Steijger, J., Stellacci, S. M., Stransky, D., Taiuti, M., Tayalati, Y., Terrasi, F., Tézier, D., Theraube, S., Timmer, P., Tönnis, C., Trasatti, L., Travaglini, R., Trovato, A., Tsirigotis, A., Tzamarias, S., Tzamariudaki, E., Vallage, B., Van Elewyck, V., Vermeulen, J., Vicini, P., Viola, S., Vivolo, D., Volkert, M., Wiggers, L., Wilms, J., de Wolf, E., Zachariadou, K., Zornoza, J. D., and Zúñiga, J.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

Studying atmospheric neutrino oscillations in the few-GeV range with a multimegaton detector promises to determine the neutrino mass hierarchy. This is the main science goal pursued by the future KM3NeT/ORCA water Cherenkov detector in the Mediterranean Sea. In this paper, the processes that limit the obtainable resolution in both energy and direction in charged-current neutrino events in the ORCA detector are investigated. These processes include the composition of the hadronic fragmentation products, the subsequent particle propagation and the photon-sampling fraction of the detector. GEANT simulations of neutrino interactions in seawater produced by GENIE are used to study the effects in the 1 - 20 GeV range. It is found that fluctuations in the hadronic cascade in conjunction with the variation of the inelasticity y are most detrimental to the resolutions. The effect of limited photon sampling in the detector is of significantly less importance. These results will therefore also be applicable to similar detectors/media, such as those in ice., Comment: 37 pages, 28 figures, JHEP published version

Published
2016
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4. Letter of Intent for KM3NeT 2.0

Author

Adrián-Martínez, S., Ageron, M., Aharonian, F., Aiello, S., Albert, A., Ameli, F., Anassontzis, E., Andre, M., Androulakis, G., Anghinolfi, M., Anton, G., Ardid, M., Avgitas, T., Barbarino, G., Barbarito, E., Baret, B., Barrios-Martí, J., Belhorma, B., Belias, A., Berbee, E., Berg, A. van den, Bertin, V., Beurthey, S., van Beveren, V., Beverini, N., Biagi, S., Biagioni, A., Billault, M., Bond, M., Bormuth, R., Bouhadef, B., Bourlis, G., Bourret, S., Boutonnet, C., Bouwhuis, M., Bozza, C., Bruijn, R., Brunner, J., Buis, E., Busto, J., Cacopardo, G., Caillat, L., Calamai, M., Calvo, D., Capone, A., Caramete, L., Cecchini, S., Celli, S., Champion, C., Moursli, R. Cherkaoui El, Cherubini, S., Chiarusi, T., Circella, M., Classen, L., Cocimano, R., Coelho, J. A. B., Coleiro, A., Colonges, S., Coniglione, R., Cordelli, M., Cosquer, A., Coyle, P., Creusot, A., Cuttone, G., D'Amico, A., De Bonis, G., De Rosa, G., De Sio, C., Di Capua, F., Di Palma, I., García, A. F. Díaz, Distefano, C., Donzaud, C., Dornic, D., Dorosti-Hasankiadeh, Q., Drakopoulou, E., Drouhin, D., Drury, L., Durocher, M., Eberl, T., Eichie, S., van Eijk, D., Bojaddaini, I. El, Khayati, N. El, Elsaesser, D., Enzenhöfer, A., Fassi, F., Favali, P., Fermani, P., Ferrara, G., Frascadore, G., Filippidis, C., Fusco, L. A., Gal, T., Galatà, S., Garufi, F., Gay, P., Gebyehu, M., Giordano, V., Gizani, N., Gracia, R., Graf, K., Grégoire, T., Grella, G., Habel, R., Hallmann, S., van Haren, H., Harissopulos, S., Heid, T., Heijboer, A., Heine, E., Henry, S., Hernández-Rey, J. J., Hevinga, M., Hofestädt, J., Hugon, C. M. F., Illuminati, G., James, C. W., Jansweijer, P., Jongen, M., de Jong, M., Kadler, M., Kalekin, O., Kappes, A., Katz, U. F., Keller, P., Kieft, G., Kießling, D., Koffeman, E. N., Kooijman, P., Kouchner, A., Kulikovskiy, V., Lahmann, R., Lamare, P., Leisos, A., Leonora, E., Clark, M. Lindsey, Liolios, A., Alvarez, C. D. Llorens, Presti, D. Lo, Löhner, H., Lonardo, A., Lotze, M., Loucatos, S., Maccioni, E., Mannheim, K., Margiotta, A., Marinelli, A., Mariş, O., Markou, C., Martínez-Mora, J. A., Martini, A., Mele, R., Melis, K. W., Michael, T., Migliozzi, P., Migneco, E., Mijakowski, P., Miraglia, A., Mollo, C. M., Mongelli, M., Morganti, M., Moussa, A., Musico, P., Musumeci, M., Navas, S., Nicolau, C. A., Olcina, I., Olivetto, C., Orlando, A., Papaikonomou, A., Papaleo, R., Păvălaş, G. E., Peek, H., Pellegrino, C., Perrina, C., Pfutzner, M., Piattelli, P., Pikounis, K., Poma, G. E., Popa, V., Pradier, T., Pratolongo, F., Pühlhofer, G., Pulvirenti, S., Quinn, L., Racca, C., Raffaelli, F., Randazzo, N., Rapidis, P., Razis, P., Real, D., Resvanis, L., Reubelt, J., Riccobene, G., Rossi, C., Rovelli, A., Saldaña, M., Salvadori, I., Samtleben, D. F. E., García, A. Sánchez, Losa, A. Sánchez, Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schimmel, F., Schmelling, J., Sciacca, V., Sedita, M., Seitz, T., Sgura, I., Simeone, F., Siotis, I., Sipala, V., Spisso, B., Spurio, M., Stavropoulos, G., Steijger, J., Stellacci, S. M., Stransky, D., Taiuti, M., Tayalati, Y., Tézier, D., Theraube, S., Thompson, L., Timmer, P., Tönnis, C., Trasatti, L., Trovato, A., Tsirigotis, A., Tzamarias, S., Tzamariudaki, E., Vallage, B., Van Elewyck, V., Vermeulen, J., Vicini, P., Viola, S., Vivolo, D., Volkert, M., Voulgaris, G., Wiggers, L., Wilms, J., de Wolf, E., Zachariadou, K., Zornoza, J. D., and Zúñiga, J.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

The main objectives of the KM3NeT Collaboration are i) the discovery and subsequent observation of high-energy neutrino sources in the Universe and ii) the determination of the mass hierarchy of neutrinos. These objectives are strongly motivated by two recent important discoveries, namely: 1) The high-energy astrophysical neutrino signal reported by IceCube and 2) the sizable contribution of electron neutrinos to the third neutrino mass eigenstate as reported by Daya Bay, Reno and others. To meet these objectives, the KM3NeT Collaboration plans to build a new Research Infrastructure consisting of a network of deep-sea neutrino telescopes in the Mediterranean Sea. A phased and distributed implementation is pursued which maximises the access to regional funds, the availability of human resources and the synergetic opportunities for the earth and sea sciences community. Three suitable deep-sea sites are identified, namely off-shore Toulon (France), Capo Passero (Italy) and Pylos (Greece). The infrastructure will consist of three so-called building blocks. A building block comprises 115 strings, each string comprises 18 optical modules and each optical module comprises 31 photo-multiplier tubes. Each building block thus constitutes a 3-dimensional array of photo sensors that can be used to detect the Cherenkov light produced by relativistic particles emerging from neutrino interactions. Two building blocks will be configured to fully explore the IceCube signal with different methodology, improved resolution and complementary field of view, including the Galactic plane. One building block will be configured to precisely measure atmospheric neutrino oscillations., Comment: 119 pages, published version, revised Eq. 6, 7

Published
2016
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5. The prototype detection unit of the KM3NeT detector

Author

KM3NeT Collaboration, Adrián-Martínez, S., Ageron, M., Aharonian, F., Aiello, S., Albert, A., Ameli, F., Anassontzis, E. G., Androulakis, G. C., Anghinolfi, M., Anton, G., Anvar, S., Ardid, M., Avgitas, T., Balasi, K., Band, H., Barbarino, G., Barbarito, E., Barbato, F., Baret, B., Baron, S., Barrios, J., Belias, A., Berbee, E., Berg, A. M. van den, Berkien, A., Bertin, V., Beurthey, S., van Beveren, V., Beverini, N., Biagi, S., Biagioni, A., Bianucci, S., Billault, M., Birbas, A., Rookhuizen, H. Boer, Bormuth, R., Bouché, V., Bouhadef, B., Bourlis, G., Boutonnet, C., Bouwhuis, M., Bozza, C., Bruijn, R., Brunner, J., Cacopardo, G., Caillat, L., Calamai, M., Calvo, D., Capone, A., Caramete, L., Caruso, F., Cecchini, S., Ceres, A., Cereseto, R., Champion, C., Château, F., Chiarusi, T., Christopoulou, B., Circella, M., Classen, L., Cocimano, R., Coleiro, A., Colonges, S., Coniglione, R., Cosquer, A., Costa, M., Coyle, P., Creusot, A., Cuttone, G., D'Amato, C., D'Amico, A., De Bonis, G., De Rosa, G., Deniskina, N., Destelle, J. -J., Distefano, C., Di Capua, F., Donzaud, C., Dornic, D., Dorosti-Hasankiadeh, Q., Drakopoulou, E., Drouhin, D., Drury, L., Durand, D., Eberl, T., Elsaesser, D., Enzenhöfer, A., Fermani, P., Fusco, L. A., Gajanana, D., Gal, T., Galatà, S., Garufi, F., Gebyehu, M., Giordano, V., Gizani, N., GraciaRuiz, R., Graf, K., Grasso, R., Grella, G., Grmek, A., Habel, R., van Haren, H., Heid, T., Heijboer, A., Heine, E., Henry, S., Hernández-Rey, J. J., Herold, B., Hevinga, M. A., van der Hoek, M., Hofestädt, J., Hogenbirk, J., Hugon, C., Hößl, J., Imbesi, M., James, C. W., Jansweijer, P., Jochum, J., de Jong, M., Jongen, M., Kadler, M., Kalekin, O., Kappes, A., Kappos, E., Katz, U., Kavatsyuk, O., Keller, P., Kieft, G., Koffeman, E., Kok, H., Kooijman, P., Koopstra, J., Korporaal, A., Kouchner, A., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Lamare, P., Larosa, G., Lattuada, D., Provost, H. Le, Leismüller, K. P., Leisos, A., Lenis, D., Leonora, E., LindseyClark, M., Alvarez, C. D. Llorens, Löhner, H., Lonardo, A., Loucatos, S., Louis, F., Maccioni, E., Mannheim, K., Manolopoulos, K., Margiotta, A., Mariş, O., Markou, C., Martínez-Mora, J. A., Martini, A., Masullo, R., Melis, K. W., Michael, T., Migliozzi, P., Migneco, E., Miraglia, A., Mollo, C. M., Mongelli, M., Morganti, M., Mos, S., Moudden, Y., Musico, P., Musumeci, M., Nicolaou, C., Nicolau, C. A., Orlando, A., Orzelli, A., Papaikonomou, A., Papaleo, R., Păvălaş, G. E., Peek, H., Pellegrino, C., Pellegriti, M. G., Perrina, C., Piattelli, P., Pikounis, K., Popa, V., Pradier, Th., Priede, M., Pühlhofer, G., Pulvirenti, S., Racca, C., Raffaelli, F., Randazzo, N., Rapidis, P. A., Razis, P., Real, D., Resvanis, L., Reubelt, J., Riccobene, G., Rovelli, A., Saldaña, M., Samtleben, D. F. E., Sanguineti, M., Santangelo, A., Sapienza, P., Schmelling, J., Schnabel, J., Sciacca, V., Sedita, M., Seitz, T., Sgura, I., Simeone, F., Sipala, V., Spitaleri, A., Spurio, M., Stavropoulos, G., Steijger, J., Stolarczyk, T., Stransky, D., Taiuti, M., Terreni, G., Tézier, D., Théraube, S., Thompson, L. F., Timmer, P., Trasatti, L., Trovato, A., Tselengidou, M., Tsirigotis, A., Tzamarias, S., Tzamariudaki, E., Vallage, B., Van Elewyck, V., Vermeulen, J., Vernin, P., Vicini, P., Viola, S., Vivolo, D., Werneke, P., Wiggers, L., Wilms, J., de Wolf, E., van Wooning, R. H. L., Zonca, E., Zornoza, J. D., Zúñiga, J., and Zwart, A.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

A prototype detection unit of the KM3NeT deep-sea neutrino telescope has been installed at 3500m depth 80km offshore the Italian coast. KM3NeT in its final configuration will contain several hundreds of detection units. Each detection unit is a mechanical structure anchored to the sea floor, held vertical by a submerged buoy and supporting optical modules for the detection of Cherenkov light emitted by charged secondary particles emerging from neutrino interactions. This prototype string implements three optical modules with 31 photomultiplier tubes each. These optical modules were developed by the KM3NeT Collaboration to enhance the detection capability of neutrino interactions. The prototype detection unit was operated since its deployment in May 2014 until its decommissioning in July 2015. Reconstruction of the particle trajectories from the data requires a nanosecond accuracy in the time calibration. A procedure for relative time calibration of the photomultiplier tubes contained in each optical module is described. This procedure is based on the measured coincidences produced in the sea by the 40K background light and can easily be expanded to a detector with several thousands of optical modules. The time offsets between the different optical modules are obtained using LED nanobeacons mounted inside them. A set of data corresponding to 600 hours of livetime was analysed. The results show good agreement with Monte Carlo simulations of the expected optical background and the signal from atmospheric muons. An almost background-free sample of muons was selected by filtering the time correlated signals on all the three optical modules. The zenith angle of the selected muons was reconstructed with a precision of about 3{\deg}., Comment: Accepted for publication by EPJ C

Published
2015
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6. Deep sea tests of a prototype of the KM3NeT digital optical module

Author

Adrián-Martínez, S., Ageron, M., Aharonian, F., Aiello, S., Albert, A., Ameli, F., Anassontzis, E. G., Anghinolfi, M., Anton, G., Anvar, S., Ardid, M., de Asmundis, R., Balasi, K., Band, H., Barbarino, G., Barbarito, E., Barbato, F., Baret, B., Baron, S., Belias, A., Berbee, E., Berg, A. M. van den, Berkien, A., Bertin, V., Beurthey, S., van Beveren, V., Beverini, N., Biagi, S., Bianucci, S., Billault, M., Birbas, A., Rookhuizen, H. Boer, Bormuth, R., Bouche, V., Bouhadef, B., Bourlis, G., Bouwhuis, M., Bozza, C., Bruijn, R., Brunner, J., Cacopardo, G., Caillat, L., Calamai, M., Calvo, D., Capone, A., Caramete, L., Caruso, F., Cecchini, S., Ceres, A., Cereseto, R., Champion, C., Chateau, F., Chiarusi, T., Christopoulou, B., Circella, M., Classen, L., Cocimano, R., Colonges, S., Coniglione, R., Cosquer, A., Costa, M., Coyle, P., Creusot, A., Curtil, C., Cuttone, G., D'Amato, C., D'Amico, A., De Bonis, G., De Rosa, G., Deniskina, N., Destelle, J. -J., Distefano, C., Donzaud, C., Dornic, D., Dorosti-Hasankiadeh, Q., Drakopoulou7, E., Drouhin, D., Drury, L., Durand, D., Eberl, T., Eleftheriadis, C., Elsaesser, D., Enzenhofer, A., Fermani, P., Fusco, L. A., Gajana, D., Gal, T., Galata, S., Gallo, F., Garufi, F., Gebyehu, M., Giordano, V., Gizani, N., Ruiz, R. Gracia, Graf, K., Grasso, R., Grella, G., Grmek, A., Habel, R., van Haren, H., Heid, T., Heijboer, A., Heine, E., Henry, S., Hernandez-Rey, J. J., Herold, B., Hevinga, M. A., van der Hoek, M., Hofestadt, J., Hogenbirk, J., Hugon, C., Hosl, J., Imbesi, M., James, C., Jansweijer, P., Jochum, J., de Jong, M., Kadler, M., Kalekin, O., Kappes, A., Kappos, E., Katz, U., Kavatsyuk, O., Keller, P., Kieft, G., Koffeman, E., Kok, H., Kooijman, P., Koopstra, J., Korporaal, A., Kouchner, A., Koutsoukos, S., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Lamare, P., Larosa, G., Lattuada, D., Provost, H. Le, Leisos, A., Lenis, D., Leonora, E., Clark, M. Lindsey, Liolios, A., Alvarez, C. D. Llorens, Lohner, H., Presti, D. Lo, Louis, F., Maccioni, E., Mannheim, K., Manolopoulos, K., Margiotta, A., Maris, O., Markou, C., Martinez-Mora, J. A., Martini, A., Masullo, R., Michael, T., Migliozzi, P., Migneco, E., Miraglia, A., Mollo, C., Mongelli, M., Morganti, M., Mos, S., Moudden, Y., Musico, P., Musumeci, M., Nicolaou, C., Nicolau, C. A., Orlando, A., Orzelli, A., Papageorgiou, K., Papaikonomou, A., Papaleo, R., Pavalas, G. E., Peek, H., Pellegrino, C., Pellegriti, M. G., Perrina, C., Petridou, C., Piattelli, P., Pikounis, K., Popa, V., Pradier, Th., Priede, M., Puhlhofer, G., Pulvirenti, S., Racca, C., Raffaelli, F., Randazzo, N., Rapidis, P. A., Razis, P., Real, D., Resvanis, L., Reubelt, J., Riccobene, G., Rovelli, A., Royon, J., Saldana, M., Samtleben, D. F. E., Sanguineti, M., Santangelo, A., Sapienza, P., Savvidis, I., Schmelling, J., Schnabel, J., Sedita, M., Seitz, T., Sgura, I., Simeone, F., Siotis, I., Sipala, V., Solazzo, M., Spitaleri, A., Spurio, M., Stavropoulos, G., Steijger, J., Stolarczyk, T., Stransky, D., Taiuti, M., Terreni, G., Tezier, D., Theraube, S., Thompson, L. F., Timmer, P., Trapierakis, H. I., Trasatti, L., Trovato, A., Tselengidou, M., Tsirigotis, A., Tzamarias, S., Tzamariudaki, E., Vallage, B., Van Elewyck, V., Vermeulen, J., Vernin, P., Viola, S., Vivolo, D., Werneke, P., Wiggers, L., Wilms, J., de Wolf, E., van Wooning, R. H. L., Yatkin, K., Zachariadou, K., Zonca, E., Zornoza, J. D., Zúñiga, J., and Zwart, A.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract

The first prototype of a photo-detection unit of the future KM3NeT neutrino telescope has been deployed in the deep waters of the Mediterranean Sea. This digital optical module has a novel design with a very large photocathode area segmented by the use of 31 three inch photomultiplier tubes. It has been integrated in the ANTARES detector for in-situ testing and validation. This paper reports on the first months of data taking and rate measurements. The analysis results highlight the capabilities of the new module design in terms of background suppression and signal recognition. The directionality of the optical module enables the recognition of multiple Cherenkov photons from the same $^{40}$K decay and the localization bioluminescent activity in the neighbourhood. The single unit can cleanly identify atmospheric muons and provide sensitivity to the muon arrival directions.

Published
2014
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7. Limits on radiative decays of solar neutrinos from a measurement during a solar eclipse

Author

Cecchini, S., Giacomelli, G., Giacomelli, R., Hasegan, D., Maris, O., Popa, V., Serra, R., Serrazanetti, M., Stefanov, L., Tasca, L., and Valeanu, V.

Subjects
High Energy Physics - Experiment
Abstract

A search for possible radiative decays of solar neutrinos with emission of photons in the visible range was performed during the total solar eclipse of August 11, 1999. Due to very bad weather conditions our two telescopes were unable to collect useful data; fortunately we obtained several video camera images from a local TV station. An analysis of the digitised images is presented and limits on the lifetime for radiative decay are discussed., Comment: 10 pages, 1 tablee, 4 PS figures included with epsfig

Published
2000
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8. Intrinsic limits on resolutions in muon- and electron-neutrino charged-current events in the KM3NeT/ORCA detector

Author

Adrián-Martínez, S., Ageron, M., Aiello, S., Albert, A., Ameli, F., Anassontzis, E. G., Andre, M., Androulakis, G., Anghinolfi, M., Anton, G., Ardid, M., Avgitas, T., Barbarino, G., Barbarito, E., Baret, B., Barrios-Mart, J., Belias, A., Berbee, E., van den Berg, A., Bertin, V., Beurthey, S., van Beveren, V., Beverini, N., Biagi, S., Biagioni, A., Billault, M., Bondì, M., Bormuth, R., Bouhadef, B., Bourlis, G., Bourret, S., Boutonnet, C., Bouwhuis, M., Bozza, C., Bruijn, R., Brunner, J., Buis, E., Buompane, R., Busto, J., Cacopardo, G., Caillat, L., Calamai, M., Calvo, D., Capone, A., Caramete, L., Cecchini, S., Celli, S., Champion, C., Cherubini, S., Chiarella, V., Chiarelli, L., Chiarusi, T., Circella, M., Classen, L., Cobas, D., Cocimano, R., Coelho, J. A. B., Coleiro, A., Colonges, S., Coniglione, R., Cordelli, M., Cosquer, A., Coyle, P., Creusot, A., Cuttone, G., D’Amato, C., D’Amico, A., D’Onofrio, A., De Bonis, G., De Sio, C., Di Palma, I., Díaz, A. F., Distefano, C., Donzaud, C., Dornic, D., Dorosti-Hasankiadeh, Q., Drakopoulou, E., Drouhin, D., Durocher, M., Eberl, T., Eichie, S., van Eijk, D., El Bojaddaini, I., Elsaesser, D., Enzenhöfer, A., Favaro, M., Fermani, P., Ferrara, G., Frascadore, G., Furini, M., Fusco, L. A., Gal, T., Galatà, S., Garufi, F., Gay, P., Gebyehu, M., Giacomini, F., Gialanella, L., Giordano, V., Gizani, N., Gracia, R., Graf, K., Grégoire, T., Grella, G., Grmek, A., Guerzoni, M., Habel, R., Hallmann, S., van Haren, H., Harissopulos, S., Heid, T., Heijboer, A., Heine, E., Henry, S., Hernández-Rey, J. J., Hevinga, M., Hofestädt, J., Hugon, C. M. F., Illuminati, G., James, C. W., Jansweijerf, P., Jongen, M., de Jong, M., Kadler, M., Kalekin, O., Kappes, A., Katz, U. F., Keller, P., Kieft, G., Kießling, D., Koffeman, E. N., Kooijman, P., Kouchner, A., Kreter, M., Kulikovskiy, V., Lahmann, R., Lamare, P., Larosa, G., Leisos, A., Leone, F., Leonora, E., Lindsey Clark, M., Liolios, A., Llorens Alvarez, C. D., Lo Presti, D., Löhner, H., Lonardo, A., Lotze, M., Loucatos, S., Maccioni, E., Mannheim, K., Manzali, M., Margiotta, A., Margotti, A., Marinelli, A., Maris, O., Markou, C., Martínez-Mora, J. A., Martini, A., Marzaioli, F., Mele, R., Melis, K. W., Michael, T., Migliozzi, P., Migneco, E., Mijakowski, P., Miraglia, A., Mollo, C. M., Mongelli, M., Morganti, M., Moussa, A., Musico, P., Musumeci, M., Navas, S., Nicolau, C. A., Olcina, I., Olivetto, C., Orlando, A., Orzelli, A., Pancaldi, G., Papaikonomou, A., Papaleo, R., Păvălas, G. E., Peek, H., Pellegrini, G., Pellegrino, C., Perrina, C., Pfutzner, M., Piattelli, P., Pikounis, K., Pleinert, M.-O., Poma, G. E., Popa, V., Pradier, T., Pratolongo, F., Pühlhofer, G., Pulvirenti, S., Quinn, L., Racca, C., Raffaelli, F., Randazzo, N., Rauch, T., Real, D., Resvanis, L., Reubelt, J., Riccobene, G., Rossi, C., Rovelli, A., Saldaña, M., Salvadori, I., Samtleben, D. F. E., Sánchez García, A., Sánchez Losa, A., Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schimmel, F., Schmelling, J., Schnabel, J., Sciacca, V., Sedita, M., Seitz, T., Sgura, I., Simeone, F., Sipala, V., Spisso, B., Spurio, M., Stavropoulos, G., Steijger, J., Stellacci, S. M., Stransky, D., Taiuti, M., Tayalati, Y., Terrasi, F., Tézier, D., Theraube, S., Timmer, P., Tönnis, C., Trasatti, L., Travaglini, R., Trovato, A., Tsirigotis, A., Tzamarias, S., Tzamariudaki, E., Vallage, B., Van Elewyck, V., Vermeulen, J., Versari, F., Vicini, P., Viola, S., Vivolo, D., Volkert, M., Wiggers, L., Wilms, J., de Wolf, E., Zachariadou, K., Zani, S., Zornoza, J. D., Zúñiga, J., and The KM3NeT collaboration

Published
2017
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9. Detection potential of the KM3NeT detector for high-energy neutrinos from the Fermi bubbles

Author

Adrián-Martínez, S., Ageron, M., Aguilar, J.A., Aharonian, F., Aiello, S., Albert, A., Alexandri, M., Ameli, F., Anassontzis, E.G., Anghinolfi, M., Anton, G., Anvar, S., Ardid, M., Assis Jesus, A., Aubert, J.-J., Bakker, R., Ball, A.E., Barbarino, G., Barbarito, E., Barbato, F., Baret, B., de Bel, M., Belias, A., Bellou, N., Berbee, E., Berkien, A., Bersani, A., Bertin, V., Beurthey, S., Biagi, S., Bigongiari, C., Bigourdan, B., Billault, M., de Boer, R., Boer Rookhuizen, H., Bonori, M., Borghini, M., Bou-Cabo, M., Bouhadef, B., Bourlis, G., Bouwhuis, M., Bradbury, S., Brown, A., Bruni, F., Brunner, J., Brunoldi, M., Busto, J., Cacopardo, G., Caillat, L., Calvo Díaz-Aldagalán, D., Calzas, A., Canals, M., Capone, A., Carr, J., Castorina, E., Cecchini, S., Ceres, A., Cereseto, R., Chaleil, Th., Chateau, F., Chiarusi, T., Choqueuse, D., Christopoulou, P.E., Chronis, G., Ciaffoni, O., Circella, M., Cocimano, R., Cohen, F., Colijn, F., Coniglione, R., Cordelli, M., Cosquer, A., Costa, M., Coyle, P., Craig, J., Creusot, A., Curtil, C., D’Amico, A., Damy, G., De Asmundis, R., De Bonis, G., Decock, G., Decowski, P., Delagnes, E., De Rosa, G., Distefano, C., Donzaud, C., Dornic, D., Dorosti-Hasankiadeh, Q., Drogou, J., Drouhin, D., Druillole, F., Drury, L., Durand, D., Durand, G.A., Eberl, T., Emanuele, U., Enzenhöfer, A., Ernenwein, J.-P., Escoffier, S., Espinosa, V., Etiope, G., Favali, P., Felea, D., Ferri, M., Ferry, S., Flaminio, V., Folger, F., Fotiou, A., Fritsch, U., Gajanana, D., Garaguso, R., Gasparini, G.P., Gasparoni, F., Gautard, V., Gensolen, F., Geyer, K., Giacomelli, G., Gialas, I., Giordano, V., Giraud, J., Gizani, N., Gleixner, A., Gojak, C., Gómez-González, J.P., Graf, K., Grasso, D., Grimaldi, A., Groenewegen, R., Guédé, Z., Guillard, G., Guilloux, F., Habel, R., Hallewell, G., van Haren, H., van Heerwaarden, J., Heijboer, A., Heine, E., Hernández-Rey, J.J., Herold, B., Hillebrand, T., van de Hoek, M., Hogenbirk, J., Hößl, J., Hsu, C.C., Imbesi, M., Jamieson, A., Jansweijer, P., de Jong, M., Jouvenot, F., Kadler, M., Kalantar-Nayestanaki, N., Kalekin, O., Kappes, A., Karolak, M., Katz, U.F., Kavatsyuk, O., Keller, P., Kiskiras, Y., Klein, R., Kok, H., Kontoyiannis, H., Kooijman, P., Koopstra, J., Kopper, C., Korporaal, A., Koske, P., Kouchner, A., Koutsoukos, S., Kreykenbohm, I., Kulikovskiy, V., Laan, M., La Fratta, C., Lagier, P., Lahmann, R., Lamare, P., Larosa, G., Lattuada, D., Leisos, A., Lenis, D., Leonora, E., Le Provost, H., Lim, G., Llorens, C.D., Lloret, J., Löhner, H., Lo Presti, D., Lotrus, P., Louis, F., Lucarelli, F., Lykousis, V., Malyshev, D., Mangano, S., Marcoulaki, E.C., Margiotta, A., Marinaro, G., Marinelli, A., Mariş, O., Markopoulos, E., Markou, C., Martínez-Mora, J.A., Martini, A., Marvaldi, J., Masullo, R., Maurin, G., Migliozzi, P., Migneco, E., Minutoli, S., Miraglia, A., Mollo, C.M., Mongelli, M., Monmarthe, E., Morganti, M., Mos, S., Motz, H., Moudden, Y., Mul, G., Musico, P., Musumeci, M., Naumann, Ch., Neff, M., Nicolaou, C., Orlando, A., Palioselitis, D., Papageorgiou, K., Papaikonomou, A., Papaleo, R., Papazoglou, I.A., Păvălaş, G.E., Peek, H.Z., Perkin, J., Piattelli, P., Popa, V., Pradier, T., Presani, E., Priede, I.G., Psallidas, A., Rabouille, C., Racca, C., Radu, A., Randazzo, N., Rapidis, P.A., Razis, P., Real, D., Reed, C., Reito, S., Resvanis, L.K., Riccobene, G., Richter, R., Roensch, K., Rolin, J., Rose, J., Roux, J., Rovelli, A., Russo, A., Russo, G.V., Salesa, F., Samtleben, D., Sapienza, P., Schmelling, J.-W., Schmid, J., Schnabel, J., Schroeder, K., Schuller, J.-P., Schussler, F., Sciliberto, D., Sedita, M., Seitz, T., Shanidze, R., Simeone, F., Siotis, I., Sipala, V., Sollima, C., Sparnocchia, S., Spies, A., Spurio, M., Staller, T., Stavrakakis, S., Stavropoulos, G., Steijger, J., Stolarczyk, Th., Stransky, D., Taiuti, M., Taylor, A., Thompson, L., Timmer, P., Tonoiu, D., Toscano, S., Touramanis, C., Trasatti, L., Traverso, P., Trovato, A., Tsirigotis, A., Tzamarias, S., Tzamariudaki, E., Urbano, F., Vallage, B., Van Elewyck, V., Vannoni, G., Vecchi, M., Vernin, P., Viola, S., Vivolo, D., Wagner, S., Werneke, P., White, R.J., Wijnker, G., Wilms, J., de Wolf, E., Yepes, H., Zhukov, V., Zonca, E., Zornoza, J.D., and Zúñiga, J.

Published
2013
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11. Dengue in the State of Rio de Janeiro, Brazil, 1986-1998

Author

Rita Maria R Nogueira, Marize P Miagostovich, Hermann G Schatzmayr, Flávia B dos Santos, Eliane S M de Araújo, Ana Maria B de Filippis, Rogério V de Souza, Sonia Maris O Zagne, Cecília Nicolai, Mary Baran, and Gualberto Teixeira Filho

Subjects
dengue, epidemics, Rio de Janeiro, diagnosis, Microbiology, QR1-502, Infectious and parasitic diseases, RC109-216
Abstract

This paper presents epidemiological, laboratory, and clinical data on 12 years of dengue virus activity in the State of Rio de Janeiro from the time the disease was first confirmed virologically in April 1986 through April 1998. DEN-1 and DEN-2 viruses are the serotypes circulating in the state and were responsible for the epidemics reported during the last 12 years. The results published here show both the impact of dengue virus infections on the population and laboratory advances that have improved dengue diagnosis.

Published
1999
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14. The power supply system of the AMS-02 tracker detector

Author

Menichelli, M., Ambrosi, G., Battiston, R., Bizzarri, M., Blasko, S., Cosson, D., Fiori, E.M., Maris, O., Papi, A., and Scolieri, G.

Subjects
Electronics -- Research, Navigation (Astronautics) -- Forecasts and trends, Astrophysics -- Research, Market trend/market analysis, Business, Electronics, Electronics and electrical industries
Abstract

This paper describes the architecture, the performance and the qualification tests of the Tracker detector power supply system for the AMS-02 experiment. The AMS-02 experiment will measure the cosmic ray spectrum from 0.5 GeV up to several TeV in space, looking for anti-matter, dark matter and strange quark matter. The experimental apparatus will be installed in the International Space Station (ISS) in year 2008. A preliminary version of this experiment has flown in 1998 on the STS-91 shuttle flight. The power supply system of the tracker has been designed optimizing noise performances, modularity and efficiency. Power is generated starting from a 28 V line coming from the power distribution box for the entire experiment. This power is converted into the needed voltages by means of DC-DC converters, and for bias supply and front-end voltages is post-regulated by means of linear regulators. Components Off The Shelf (COTS) have been extensively used in the construction of this power supply, however various radiation test campaigns have been performed in order to verify the reliability of these components. Active components were tested for total dose radiation damage and digital components were also tested for single event effects. The power supply architecture developed for the tracker detector has been used as a guideline for the development of the power supplies for the other detectors in the experiment. Index Terms--Electronics, particle astrophysics, power supply, space qualification.

Published
2006

15. Intrinsic limits on resolutions in muon and electron-neutrino charged-current events in the KM3NeT/ORCA detector

Author

The KM3NeT collaboration, Adrián, Martínez, Ageron, S., Aiello, M., Albert, S., Ameli, A., Anassontzis, F., E. G., Andre, Androulakis, M., Anghinolfi, G., Anton, M., Ardid, G., Avgitas, M., Barbarino, T., Barbarito, G., Baret, E., Barrios, Mart, Belias, J., Berbee, A., van den Berg, Bertin, A., Beurthey, V., Van, Beveren, Beverini, V., Biagi, N., Biagioni, S., Billault, A., Bondì, M., Bormuth, M., Bouhadef, R., Bourlis, B., Bourret, G., Boutonnet, S., Bouwhuis, C., Bozza, M., Bruijn, C., Brunner, R., Buis, J., Buompane, E., Busto, R., Cacopardo, J., Caillat, G., Calamai, L., Calvo, M., Capone, D., Caramete, A., Cecchini, L., Celli, S., Champion, S., Cherubini, Silvio, Chiarella, V., Chiarelli, L., Chiarusi, T., Circella, M., Classen, L., Cobas, D., Cocimano, R., Coelho, J. A. B., Coleiro, A., Colonges, S., Coniglione, R., Cordelli, M., Cosquer, A., Coyle, P., Creusot, A., Cuttone, G., D’Amato, C., D’Amico, A., D’Onofrio, A., Bonis, De, Sio, De, Palma, Di, Díaz, I., A. F., Distefano, Donzaud, C., Dornic, C., Dorosti, Hasankiadeh, Drakopoulou, Q., Drouhin, E., Durocher, D., Eberl, M., Eichie, T., Van, Eijk, Bojaddaini, El, Elsaesser, I., Enzenhöfer, D., Favaro, A., Fermani, M., Ferrara, P., Frascadore, G., Furini, G., Fusco, M., L. A., Gal, Galatà, T., Garufi, S., Gay, F., Gebyehu, P., Giacomini, M., Gialanella, F., Giordano, L., Gizani, V., Gracia, N., Graf, R., Grégoire, K., Grella, T., Grmek, G., Guerzoni, A., Habel, M., Hallmann, R., Van, Haren, Harissopulos, H., Heid, S., Heijboer, T., Heine, A., Henry, E., Hernández, Rey, J. J., Hevinga, Hofestädt, M., Hugon, J., C. M. F., Illuminati, James, G., C. W., Jansweijerf, Jongen, P., Jong, De, Kadler, M., Kalekin, M., Kappes, O., Katz, A., U. F., Keller, Kieft, P., Kießling, G., Koffeman, D., E. N., Kooijman, Kouchner, P., Kreter, A., Kulikovskiy, M., Lahmann, V., Lamare, R., Larosa, P., Leisos, G., Leone, Francesco, Leonora, E., Lindsey, Clark, Liolios, M., Llorens, Alvarez, C. D., LO PRESTI, Domenico, Löhner, H., Lonardo, A., Lotze, M., Loucatos, S., Maccioni, E., Mannheim, K., Manzali, M., Margiotta, A., Margotti, A., Marinelli, A., Maris, O., Markou, C., Martínez, Mora, J. A., Martini, Marzaioli, A., Mele, F., Melis, R., K. W., Michael, Migliozzi, T., Migneco, P., Mijakowski, E., Miraglia, P., Mollo, A., C. M., Mongelli, Morganti, M., Moussa, M., Musico, A., Musumeci, P., Navas, M., Nicolau, S., C. A., Olcina, Olivetto, I., Orlando, C., Orzelli, A., Pancaldi, A., Papaikonomou, G., Papaleo, A., Păvălas, R., G. E., Peek, Pellegrini, H., Pellegrino, G., Perrina, C., Pfutzner, C., Piattelli, M., Pikounis, P., Pleinert, K., M. O., Poma, G. E., Popa, Pradier, V., Pratolongo, T., Pühlhofer, F., Pulvirenti, G., Quinn, S., Racca, L., Raffaelli, C., Randazzo, F., Rauch, N., Real, T., Resvanis, D., Reubelt, L., Riccobene, J., Rossi, G., Rovelli, C., Saldaña, A., Salvadori, M., Samtleben, I., D. F. E., Sánchez, García, Sánchez, Losa, Sanguineti, A., Santangelo, M., Santonocito, A., Sapienza, D., Schimmel, P., Schmelling, F., Schnabel, J., Sciacca, J., Sedita, V., Seitz, M., Sgura, T., Simeone, I., Sipala, F., Spisso, V., Spurio, B., Stavropoulos, M., Steijger, G., Stellacci, J., S. M., Stransky, Taiuti, D., Tayalati, M., Terrasi, Y., Tézier, F., Theraube, D., Timmer, S., Tönnis, P., Trasatti, C., Travaglini, L., Trovato, R., Tsirigotis, A., Tzamarias, A., Tzamariudaki, S., Vallage, E., Van, Elewyck, Vermeulen, V., Versari, J., Vicini, F., Viola, P., Vivolo, S., Volkert, D., Wiggers, M., Wilms, L., Wolf, De, Zachariadou, E., Zani, K., Zornoza, S., J. D., Zúñiga, KM3NeT (IHEF, IoP, FNWI), ATLAS (IHEF, IoP, FNWI), Research unit Astroparticle Physics, Research unit Nuclear & Hadron Physics, Adrian-Martinez, S, Ageron, M, Aiello, S, Albert, A, Ameli, F, Anassontzis, Eg, Andre, M, Androulakis, G, Anghinolfi, M, Anton, G, Ardid, M, Avgitas, T, Barbarino, G, Barbarito, E, Baret, B, Barrios-Marti, J, Belias, A, Berbee, E, van den Berg, A, Bertin, V, Beurthey, S, van Beveren, V, Beverini, N, Biagi, S, Biagioni, A, Billault, M, Bondi, M, Bormuth, R, Bouhadef, B, Bourlis, G, Bourret, S, Boutonnet, C, Bouwhuis, M, Bozza, C, Bruijn, R, Brunner, J, Buis, E, Buompane, R, Busto, J, Cacopardo, G, Caillat, L, Calamai, M, Calvo, D, Capone, A, Caramete, L, Cecchini, S, Celli, S, Champion, C, Cherubini, S, Chiarella, V, Chiarelli, L, Chiarusi, T, Circella, M, Classen, L, Cobas, D, Cocimano, R, Coelho, Jab, Coleiro, A, Colonges, S, Coniglione, R, Cordelli, M, Cosquer, A, Coyle, P, Creusot, A, Cuttone, G, D'Amato, C, D'Amico, A, D'Onofrio, A, De Bonis, G, De Sio, C, Di Palma, I, Diaz, Af, Distefano, C, Donzaud, C, Dornic, D, Dorosti-Hasankiadeh, Q, Drakopoulou, E, Drouhin, D, Durocher, M, Eberl, T, Eichie, S, van Eijk, D, El Bojaddaini, I, Elsaesser, D, Enzenhofer, A, Favaro, M, Fermani, P, Ferrara, G, Frascadore, G, Furini, M, Fusco, La, Gal, T, Galata, S, Garufi, F, Gay, P, Gebyehu, M, Giacomini, F, Gialanella, L, Giordano, V, Gizani, N, Gracia, R, Graf, K, Gregoire, T, Grella, G, Grmek, A, Guerzoni, M, Habel, R, Hallmann, S, van Haren, H, Harissopulos, S, Heid, T, Heijboer, A, Heine, E, Henry, S, Hernandez-Rey, Jj, Hevinga, M, Hofestadt, J, Hugon, Cmf, Illuminati, G, James, Cw, Jansweijer, P, Jongen, M, de Jong, M, Kadler, M, Kalekin, O, Kappes, A, Katz, Uf, Keller, P, Kieft, G, Kiessling, D, Koffeman, En, Kooijman, P, Kouchner, A, Kreter, M, Kulikovskiy, V, Lahmann, R, Lamare, P, Larosa, G, Leisos, A, Leone, F, Leonora, E, Clark, Ml, Liolios, A, Alvarez, Cdl, Lo Presti, D, Lohner, H, Lonardo, A, Lotze, M, Loucatos, S, Maccioni, E, Mannheim, K, Manzali, M, Margiotta, A, Margotti, A, Marinelli, A, Maris, O, Markou, C, Martinez-Mora, Ja, Martini, A, Marzaioli, F, Mele, R, Melis, Kw, Michael, T, Migliozzi, P, Migneco, E, Mijakowski, P, Miraglia, A, Mollo, Cm, Mongelli, M, Morganti, M, Moussa, A, Musico, P, Musumeci, M, Navas, S, Nicolau, Ca, Olcina, I, Olivetto, C, Orlando, A, Orzelli, A, Pancaldi, G, Papaikonomou, A, Papaleo, R, Pavalas, Ge, Peek, H, Pellegrini, G, Pellegrino, C, Perrina, C, Pfutzner, M, Piattelli, P, Pikounis, K, Pleinert, Mo, Poma, Ge, Popa, V, Pradier, T, Pratolongo, F, Puhlhofer, G, Pulvirenti, S, Quinn, L, Racca, C, Raffaelli, F, Randazzo, N, Rauch, T, Real, D, Resvanis, L, Reubelt, J, Riccobene, G, Rossi, C, Rovelli, A, Saldana, M, Salvadori, I, Samtleben, Dfe, Garcia, A, Losa, A, Sanguineti, M, Santangelo, A, Santonocito, D, Sapienza, P, Schimmel, F, Schmelling, J, Schnabel, J, Sciacca, V, Sedita, M, Seitz, T, Sgura, I, Simeone, F, Sipala, V, Spisso, B, Spurio, M, Stavropoulos, G, Steijger, J, Stellacci, Sm, Stransky, D, Taiuti, M, Tayalati, Y, Terrasi, F, Tezier, D, Theraube, S, Timmer, P, Tonnis, C, Trasatti, L, Travaglini, R, Trovato, A, Tsirigotis, A, Tzamarias, S, Tzamariudaki, E, Vallage, B, Van Elewyck, V, Vermeulen, J, Versari, F, Vicini, P, Viola, S, Vivolo, D, Volkert, M, Wiggers, L, Wilms, J, de Wolf, E, Zachariadou, K, Zani, S, Zornoza, Jd, Zuniga, J, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), KM3NeT, Centre Tecnològic de Vilanova i la Geltrú, Universitat Politècnica de Catalunya. LAB - Laboratori d'Aplicacions Bioacústiques, Adrián Martínez, S., Ageron, M., Aiello, S., Albert, A., Ameli, F., Anassontzis, E. G., Andre, M., Androulakis, G., Anghinolfi, M., Anton, G., Ardid, M., Avgitas, T., Barbarino, G., Barbarito, E., Baret, B., Barrios Mart, J., Belias, A., Berbee, E., van den Berg, A., Bertin, V., Beurthey, S., van Beveren, V., Beverini, N., Biagi, S., Biagioni, A., Billault, M., Bondì, M., Bormuth, R., Bouhadef, B., Bourlis, G., Bourret, S., Boutonnet, C., Bouwhuis, M., Bozza, C., Bruijn, R., Brunner, J., Buis, E., Buompane, R., Busto, J., Cacopardo, G., Caillat, L., Calamai, M., Calvo, D., Capone, A., Caramete, L., Cecchini, S., Celli, S., Champion, C., Cherubini, S., Chiarella, V., Chiarelli, L., Chiarusi, T., Circella, M., Classen, L., Cobas, D., Cocimano, R., Coelho, J. A. B., Coleiro, A., Colonges, S., Coniglione, R., Cordelli, M., Cosquer, A., Coyle, P., Creusot, A., Cuttone, G., D’Amato, C., D’Amico, A., D'Onofrio, Antonio, De Bonis, G., De Sio, C., Di Palma, I., Díaz, A. F., Distefano, C., Donzaud, C., Dornic, D., Dorosti Hasankiadeh, Q., Drakopoulou, E., Drouhin, D., Durocher, M., Eberl, T., Eichie, S., van Eijk, D., El Bojaddaini, I., Elsaesser, D., Enzenhöfer, A., Favaro, M., Fermani, P., Ferrara, G., Frascadore, G., Furini, M., Fusco, L. A., Gal, T., Galatà, S., Garufi, F., Gay, P., Gebyehu, M., Giacomini, F., Gialanella, Lucio, Giordano, V., Gizani, N., Gracia, R., Graf, K., Grégoire, T., Grella, G., Grmek, A., Guerzoni, M., Habel, R., Hallmann, S., van Haren, H., Harissopulos, S., Heid, T., Heijboer, A., Heine, E., Henry, S., Hernández Rey, J. J., Hevinga, M., Hofestädt, J, Hugon, C. M. F., Illuminati, G., James, C. W., Jansweijerf, P., Jongen, M., de Jong, M., Kadler, M., Kalekin, O., Kappes, A., Katz, U. F., Keller, P., Kieft, G., Kießling, D., Koffeman, E. N., Kooijman, P., Kouchner, A., Kreter, M., Kulikovskiy, V., Lahmann, R., Lamare, P., Larosa, G., Leisos, A., Leone, F., Leonora, E., Lindsey Clark, M., Liolios, A., Llorens Alvarez, C. D., Lo Presti, D., Löhner, H., Lonardo, A., Lotze, M., Loucatos, S., Maccioni, E., Mannheim, K., Manzali, M., Margiotta, A., Margotti, A., Marinelli, A., Maris, O., Markou, C., Martínez Mora, J. A., Martini, A., Marzaioli, Fabio, Mele, R., Melis, K. W., Michael, T., Migliozzi, P., Migneco, E., Mijakowski, P., Miraglia, A., Mollo, C. M., Mongelli, M., Morganti, M., Moussa, A., Musico, P., Musumeci, M., Navas, S., Nicolau, C. A., Olcina, I., Olivetto, C., Orlando, Antonio, Orzelli, A., Pancaldi, G., Papaikonomou, A., Papaleo, R., Păvălas, G. E., Peek, H., Pellegrini, G., Pellegrino, C., Perrina, C., Pfutzner, M., Piattelli, P., Pikounis, K., Pleinert, M. O., Poma, G. E., Popa, V., Pradier, T., Pratolongo, F., Pühlhofer, G., Pulvirenti, S., Quinn, L., Racca, C., Raffaelli, F., Randazzo, N., Rauch, T., Real, D., Resvanis, L., Reubelt, J., Riccobene, G., Rossi, C., Rovelli, A., Saldaña, M., Salvadori, I., Samtleben, D. F. E., Sánchez García, A., Sánchez Losa, A., Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schimmel, F., Schmelling, J., Schnabel, J., Sciacca, V., Sedita, M., Seitz, T., Sgura, I., Simeone, F., Sipala, V., Spisso, B., Spurio, M., Stavropoulos, G., Steijger, J., Stellacci, S. M., Stransky, D., Taiuti, M., Tayalati, Y., Terrasi, Filippo, Tézier, D., Theraube, S., Timmer, P., Tönnis, C., Trasatti, L., Travaglini, R., Trovato, A., Tsirigotis, A., Tzamarias, S., Tzamariudaki, E., Vallage, B., Van Elewyck, V., Vermeulen, J., Versari, F., Vicini, P., Viola, S., Vivolo, D., Volkert, M., Wiggers, L., Wilms, J., de Wolf, E., Zachariadou, K., Zani, S., Zornoza, J. D., Zúñiga, J., Barbarino, Giancarlo, D’Onofrio, A., Garufi, Fabio, Gialanella, L., Hofestädt, J., Marzaioli, F., Orlando, A., Terrasi, F., Vivolo, Daniele, Adrián-Martínez, S., Barrios-Mart, J., Dorosti-Hasankiadeh, Q., Hernández-Rey, J. J., Martínez-Mora, J. A., and Pleinert, M.-O.

Subjects
Astrofísica, Photon, Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, High Tech Systems & Materials, 01 natural sciences, law.invention, High Energy Physics - Experiment, ENERGY, High Energy Physics - Experiment (hep-ex), High Energy Physics - Phenomenology (hep-ph), law, neutrino Telescopes, Charged current, OPT - Optics, Physics, TS - Technical Sciences, Industrial Innovation, SEA, Detector, Instrumentation and Detectors (physics.ins-det), OPTICAL-PROPERTIES, High Energy Physics - Phenomenology, Astronomy--Observations, Neutrino Detectors, Nano Technology, Neutrino, Nuclear and High Energy Physics, TELESCOPE, Cherenkov detector, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Nuclear physics, 0103 physical sciences, lcsh:Nuclear and particle physics. Atomic energy. Radioactivity, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 14. Life underwater, Neutrins, Neutrinos, 010306 general physics, Muon, 010308 nuclear & particles physics, GENERATOR, Neutrino Detectors and Telescopes (experiments), Neutrino astrophysics, KM3NeT, Física::Astronomia i astrofísica [Àrees temàtiques de la UPC], FISICA APLICADA, lcsh:QC770-798, High Energy Physics::Experiment, Electronics, Electron neutrino
Abstract

Studying atmospheric neutrino oscillations in the few-GeV range with a multimegaton detector promises to determine the neutrino mass hierarchy. This is the main science goal pursued by the future KM3NeT/ORCA water Cherenkov detector in the Mediterranean Sea. In this paper, the processes that limit the obtainable resolution in both energy and direction in charged-current neutrino events in the ORCA detector are investigated. These processes include the composition of the hadronic fragmentation products, the subsequent particle propagation and the photon-sampling fraction of the detector. GEANT simulations of neutrino interactions in seawater produced by GENIE are used to study the effects in the 1 - 20 GeV range. It is found that fluctuations in the hadronic cascade in conjunction with the variation of the inelasticity y are most detrimental to the resolutions. The effect of limited photon sampling in the detector is of significantly less importance. These results will therefore also be applicable to similar detectors/media, such as those in ice., 37 pages, 28 figures, JHEP published version

Published
2017

18. Stratifying Minimal Versus Severe Pain in Knee Osteoarthritis Using a Musculoskeletal Ultrasound Protocol

Author

Millicent Tan‐Ong, Daniel Feliciano, Consuelo B. Gonzalez-Suarez, Andrea Kristina Malvar, Svetlana Maris O. Aycardo, Ronald Christopher A Cua, Bee Giok Tan-Sales, Robert Chan, Francisco de los Reyes, and Mary Monica Bernardo‐Bueno

Subjects
Male, medicine.medical_specialty, Knee Joint, Philippines, Osteoarthritis, Severity of Illness Index, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Clinical Protocols, Synovitis, medicine, Cluster Analysis, Humans, Radiology, Nuclear Medicine and imaging, Aged, Ultrasonography, Inflammation, 030219 obstetrics & reproductive medicine, Radiological and Ultrasound Technology, Receiver operating characteristic, business.industry, Cartilage, Ultrasound, Reproducibility of Results, Middle Aged, Osteoarthritis, Knee, medicine.disease, Arthralgia, medicine.anatomical_structure, Cross-Sectional Studies, Joint pain, Female, Radiology, Tendinopathy, medicine.symptom, business, Medial meniscus
Abstract

Objective The aim of this cross-sectional correlational study was to determine the association of pain with morphologic and inflammatory sonographic findings in patients with knee osteoarthritis. Methods A total of 113 participants with knee osteoarthritis were assessed using visual analog scale pain score and sonography. Ultrasound evaluation included morphologic changes (ie, articular cartilage degeneration, medial and lateral meniscal protrusion, and presence of osteophytes on the joint margins) and inflammatory changes (ie suprapatellar effusion and/or synovitis, Baker cyst, superficial and deep infrapatellar effusion, pes anserine tendinopathy, and Hoffa panniculitis). Results Cluster analysis via Ward's method grouped patients with minimal pain (visual analog scale score, 0-4) and with substantial pain (visual analog scale score, 5-10). Stepwise logistic regression yielded 5 variables that significantly explained the variation in the probability of perceived substantial pain at 10% level of significance: lateral cartilage clarity (LCC; P = .025), medial cartilage clarity (MCC; P = .20), medial cartilage thickness (MCT; P = .041), medial meniscus protrusion (MMP) (P = .029), and osteophytes at medial femoral margin (P = .082), with 63% overall prediction accuracy. When age and sex were added, 4 variables remained significant at a 10% level of significance: LCC, MCC, MCT, and MMP, with 65% overall prediction accuracy. The receiver operating characteristic curve of this model was 0.667. Conclusion The study was able to demonstrate that morphologic abnormalities in the ultrasound parameters for LCC, MCC, MCT, and MMP were able to predict significant joint pain in knee osteoarthritis. There were no inflammatory changes that contributed to significant joint pain in this study.

Published
2018

19. Intrinsic limits on resolutions in muon- and electron-neutrino charged-current events in the KM3NeT/ORCA detector

Author

Adrian-Martinez, S. Ageron, M. Aiello, S. Albert, A. and Ameli, F. Anassontzis, E. G. Andre, M. Androulakis, G. and Anghinolfi, M. Anton, G. Ardid, M. Avgitas, T. and Barbarino, G. Barbarito, E. Baret, B. Barrios-Marti, J. and Belias, A. Berbee, E. van den Berg, A. Bertin, V. and Beurthey, S. van Beveren, V. Beverini, N. Biagi, S. and Biagioni, A. Billault, M. Bondi, M. Bormuth, R. and Bouhadef, B. Bourlis, G. Bourret, S. Boutonnet, C. and Bouwhuis, M. Bozza, C. Bruijn, R. Brunner, J. Buis, E. and Buompane, R. Busto, J. Cacopardo, G. Caillat, L. and Calamai, M. Calvo, D. Capone, A. Caramete, L. Cecchini, S. Celli, S. Champion, C. Cherubini, S. Chiarella, V. and Chiarelli, L. Chiarusi, T. Circella, M. Classen, L. and Cobas, D. Cocimano, R. Coelho, J. A. B. Coleiro, A. and Colonges, S. Coniglione, R. Cordelli, M. Cosquer, A. and Coyle, P. Creusot, A. Cuttone, G. D'Amato, C. D'Amico, A. D'Onofrio, A. De Bonis, G. De Sio, C. Di Palma, I. and Diaz, A. F. Distefano, C. Donzaud, C. Dornic, D. and Dorosti-Hasankiadeh, Q. Drakopoulou, E. Drouhin, D. and Durocher, M. Eberl, T. Eichie, S. van Eijk, D. El Bojaddaini, I. Elsaesser, D. Enzenhofer, A. Favaro, M. and Fermani, P. Ferrara, G. Frascadore, G. Furini, M. Fusco, L. A. Gal, T. Galata, S. Garufi, F. Gay, P. Gebyehu, M. Giacomini, F. Gialanella, L. Giordano, V. Gizani, N. and Gracia, R. Graf, K. Gregoire, T. Grella, G. Grmek, A. Guerzoni, M. Habel, R. Hallmann, S. van Haren, H. and Harissopulos, S. Heid, T. Heijboer, A. Heine, E. Henry, S. Hernandez-Rey, J. J. Hevinga, M. Hofestaedt, J. and Hugon, C. M. F. Illuminati, G. James, C. W. Jansweijer, P. and Jongen, M. de Jong, M. Kadler, M. Kalekin, O. and Kappes, A. Katz, U. F. Keller, P. Kieft, G. Kiessling, D. Koffeman, E. N. Kooijman, P. Kouchner, A. Kreter, M. and Kulikovskiy, V. Lahmann, R. Lamare, P. Larosa, G. and Leisos, A. Leone, F. Leonora, E. Clark, M. Lindsey and Liolios, A. Llorens Alvarez, C. D. Lo Presti, D. Lohner, H. and Lonardo, A. Lotze, M. Loucatos, S. Maccioni, E. and Mannheim, K. Manzali, M. Margiotta, A. Margotti, A. and Marinelli, A. Maris, O. Markou, C. Martinez-Mora, J. A. and Martini, A. Marzaioli, F. Mele, R. Melis, K. W. Michael, T. Migliozzi, P. Migneco, E. Mijakowski, P. Miraglia, A. and Mollo, C. M. Mongelli, M. Morganti, M. Moussa, A. and Musico, P. Musumeci, M. Navas, S. Nicolau, C. A. Olcina, I. Olivetto, C. Orlando, A. Orzelli, A. Pancaldi, G. and Papaikonomou, A. Papaleo, R. Pavalas, G. E. Peek, H. and Pellegrini, G. Pellegrino, C. Perrina, C. Pfutzner, M. and Piattelli, P. Pikounis, K. Pleinert, M. -O. Poma, G. E. and Popa, V. Pradier, T. Pratolongo, F. Puehlhofer, G. and Pulvirenti, S. Quinn, L. Racca, C. Raffaelli, F. and Randazzo, N. Rauch, T. Real, D. Resvanis, L. Reubelt, J. and Riccobene, G. Rossi, C. Rovelli, A. Saldana, M. and Salvadori, I. Samtleben, D. F. E. Garcia, A. Sanchez Losa, A. Sanchez Sanguineti, M. Santangelo, A. Santonocito, D. and Sapienza, P. Schimmel, F. Schmelling, J. Schnabel, J. and Sciacca, V. Sedita, M. Seitz, T. Sgura, I. Simeone, F. and Sipala, V. Spisso, B. Spurio, M. Stavropoulos, G. and Steijger, J. Stellacci, S. M. Stransky, D. Taiuti, M. and Tayalati, Y. Terrasi, F. Tezier, D. Theraube, S. Timmer, P. Tonnis, C. Trasatti, L. Travaglini, R. Trovato, A. and Tsirigotis, A. Tzamarias, S. Tzamariudaki, E. Vallage, B. Van Elewyck, V. Vermeulen, J. Versari, F. Vicini, P. and Viola, S. Vivolo, D. Volkert, M. Wiggers, L. Wilms, J. de Wolf, E. Zachariadou, K. Zani, S. Zornoza, J. D. and Zuniga, J. KM3NeT Collaboration

Subjects
Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Experiment
Abstract

Studying atmospheric neutrino oscillations in the few-GeV range with a multimegaton detector promises to determine the neutrino mass hierarchy. This is the main science goal pursued by the future KM3NeT/ORCA water Cherenkov detector in the Mediterranean Sea. In this paper, the processes that limit the obtainable resolution in both energy and direction in charged-current neutrino events in the ORCA detector are investigated. These processes include the composition of the hadronic fragmentation products, the subsequent particle propagation and the photon-sampling fraction of the detector. GEANT simulations of neutrino interactions in seawater produced by GENIE are used to study the effects in the 1-20 GeV range. It is found that fluctuations in the hadronic cascade in conjunction with the variation of the inelasticity y are most detrimental to the resolutions. The effect of limited photon sampling in the detector is of significantly less importance. These results will therefore also be applicable to similar detectors/media, such as those in ice.

Published
2017

20. Stratifying Minimal Versus Severe Pain in Knee Osteoarthritis Using a Musculoskeletal Ultrasound Protocol

Author

Bernardo‐Bueno, Mary Monica, primary, Gonzalez‐Suarez, Consuelo B., additional, Malvar, Andrea Kristina, additional, Cua, Ronald, additional, Feliciano, Daniel, additional, Tan‐Sales, Bee Giok, additional, Aycardo, Svetlana Maris O., additional, Tan‐Ong, Millicent, additional, Chan, Robert, additional, and De Los Reyes, Francisco, additional

Published
2018
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21. A-Si Solar cells prepared by the glow discharge technique

Author

Schmitt, J. P. M., Solems, S. A., Winterling, G., Willeke, G., Nagels, P., Brongersma, H. H., Verlinde, A. S., van Daal, H. J., de Rosny, G., Maris, O., Fogarassy, E., Siffert, P., Bauer, G. H., Schmidbaur, H., Delgado, L., Bullot, J., Gislon, R., Norenza, J. L., Sardin, G., Roch, C., Metselaar, J. W., Kleefstra, M., Rapakoulias, D., Cramarossa, F., Guimarães, L. J. M., Palz, W., editor, van Overstraeten, R., editor, and Caratti, G., editor

Published
1988
Full Text
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23. Letter of intent for KM3NeT 2.0

Author

Adrian-Martinez, S. Ageron, M. Aharonian, F. Aiello, S. and Albert, A. Ameli, F. Anassontzis, E. Andre, M. and Androulakis, G. Anghinolfi, M. Anton, G. Ardid, M. and Avgitas, T. Barbarino, G. Barbarito, E. Baret, B. and Barrios-Marti, J. Belhorma, B. Belias, A. Berbee, E. van den Berg, A. Bertin, V. Beurthey, S. van Beveren, V. and Beverini, N. Biagi, S. Biagioni, A. Billault, M. Bondi, M. Bormuth, R. Bouhadef, B. Bourlis, G. Bourret, S. and Boutonnet, C. Bouwhuis, M. Bozza, C. Bruijn, R. Brunner, J. Buis, E. Busto, J. Cacopardo, G. Caillat, L. and Calamai, M. Calvo, D. Capone, A. Caramete, L. Cecchini, S. Celli, S. Champion, C. Cherkaoui El Moursli, R. and Cherubini, S. Chiarusi, T. Circella, M. Classen, L. and Cocimano, R. Coelho, J. A. B. Coleiro, A. Colonges, S. and Coniglione, R. Cordelli, M. Cosquer, A. Coyle, P. and Creusot, A. Cuttone, G. D'Amico, A. De Bonis, G. De Rosa, G. De Sio, C. Di Capua, F. Di Palma, I. Diaz Garcia, A. F. Distefano, C. Donzaud, C. Dornic, D. and Dorosti-Hasankiadeh, Q. Drakopoulou, E. Drouhin, D. Drury, L. Durocher, M. Eberl, T. Eichie, S. van Eijk, D. El Bojaddaini, I. El Khayati, N. Elsaesser, D. Enzenhofer, A. and Fassi, F. Favali, P. Fermani, P. Ferrara, G. and Filippidis, C. Frascadore, G. Fusco, L. A. Gal, T. and Galata, S. Garufi, F. Gay, P. Gebyehu, M. Giordano, V. and Gizani, N. Gracia, R. Graf, K. Gregoire, T. Grella, G. Habel, R. Hallmann, S. van Haren, H. Harissopulos, S. and Heid, T. Heijboer, A. Heine, E. Henry, S. and Hernandez-Rey, J. J. Hevinga, M. Hofestaedt, J. Hugon, C. M. F. Illuminati, G. James, C. W. Jansweijer, P. Jongen, M. and de Jong, M. Kadler, M. Kalekin, O. Kappes, A. Katz, U. F. Keller, P. Kieft, G. Kiessling, D. Koffeman, E. N. and Kooijman, P. Kouchner, A. Kulikovskiy, V. Lahmann, R. and Lamare, P. Leisos, A. Leonora, E. Clark, M. Lindsey and Liolios, A. Llorens Alvarez, C. D. Lo Presti, D. Lohner, H. and Lonardo, A. Lotze, M. Loucatos, S. Maccioni, E. and Mannheim, K. Margiotta, A. Marinelli, A. Maris, O. and Markou, C. Martinez-Mora, J. A. Martini, A. Mele, R. and Melis, K. W. Michael, T. Migliozzi, P. Migneco, E. and Mijakowski, P. Miraglia, A. Mollo, C. M. Mongelli, M. and Morganti, M. Moussa, A. Musico, P. Musumeci, M. Navas, S. Nicolau, C. A. Olcina, I. Olivetto, C. Orlando, A. and Papaikonomou, A. Papaleo, R. Pavalas, G. E. Peek, H. and Pellegrino, C. Perrina, C. Pfutzner, M. Piattelli, P. and Pikounis, K. Poma, G. E. Popa, V. Pradier, T. and Pratolongo, F. Puehlhofer, G. Pulvirenti, S. Quinn, L. and Racca, C. Raffaelli, F. Randazzo, N. Rapidis, P. Razis, P. Real, D. Resvanis, L. Reubelt, J. Riccobene, G. and Rossi, C. Rovelli, A. Saldana, M. Salvadori, I. and Samtleben, D. F. E. Garcia, A. Sanchez Losa, A. Sanchez and Sanguineti, M. Santangelo, A. Santonocito, D. Sapienza, P. and Schimmel, F. Schmelling, J. Sciacca, V. Sedita, M. and Seitz, T. Sgura, I. Simeone, F. Siotis, I. Sipala, V. and Spisso, B. Spurio, M. Stavropoulos, G. Steijger, J. and Stellacci, S. M. Stransky, D. Taiuti, M. Tayalati, Y. and Tezier, D. Theraube, S. Thompson, L. Timmer, P. Tonnis, C. Trasatti, L. Trovato, A. Tsirigotis, A. Tzamarias, S. and Tzamariudaki, E. Vallage, B. Van Elewyck, V. Vermeulen, J. Vicini, P. Viola, S. Vivolo, D. Volkert, M. and Voulgaris, G. Wiggers, L. Wilms, J. de Wolf, E. and Zachariadou, K. Zornoza, J. D. Zuniga, J.

Subjects
Astrophysics::High Energy Astrophysical Phenomena, Astrophysics::Instrumentation and Methods for Astrophysics
Abstract

The main objectives of the KM3NeT Collaboration are (i) the discovery and subsequent observation of high-energy neutrino sources in the Universe and (ii) the determination of the mass hierarchy of neutrinos. These objectives are strongly motivated by two recent important discoveries, namely: (1) the high-energy astrophysical neutrino signal reported by IceCube and (2) the sizable contribution of electron neutrinos to the third neutrino mass eigenstate as reported by Daya Bay, Reno and others. To meet these objectives, the KM3NeT Collaboration plans to build a new Research Infrastructure consisting of a network of deep-sea neutrino telescopes in the Mediterranean Sea. A phased and distributed implementation is pursued which maximises the access to regional funds, the availability of human resources and the synergistic opportunities for the Earth and sea sciences community. Three suitable deep-sea sites are selected, namely off-shore Toulon (France), Capo Passero (Sicily, Italy) and Pylos (Peloponnese, Greece). The infrastructure will consist of three so-called building blocks. A building block comprises 115 strings, each string comprises 18 optical modules and each optical module comprises 31 photo-multiplier tubes. Each building block thus constitutes a three-dimensional array of photo sensors that can be used to detect the Cherenkov light produced by relativistic particles emerging from neutrino interactions. Two building blocks will be sparsely configured to fully explore the IceCube signal with similar instrumented volume, different methodology, improved resolution and complementary field of view, including the galactic plane. One building block will be densely configured to precisely measure atmospheric neutrino oscillations.

Published
2016

24. Differential regulation of toll-like receptor-2, toll-like receptor-4, CD16 and human leucocyte antigen-DR on peripheral blood monocytes during mild and severe dengue fever

Author

Luzia Maria de Oliveira-Pinto, Elzinandes Leal de Azeredo, Sônia Regina Nogueira Ignácio Reis, Allan R. Alvarenga, Patrícia C.F. Neves-Souza, Sonia-Maris O Zagne, Rita Maria Ribeiro Nogueira, Claire Fernandes Kubelka, and Amanda Torrentes-Carvalho

Subjects
CD14, Monocyte, Immunology, Dengue virus, CD16, Biology, medicine.disease, medicine.disease_cause, Virology, Dengue fever, TLR2, Interleukin 10, medicine.anatomical_structure, medicine, Immunology and Allergy, Cell activation
Abstract

Dengue fever (DF), a public health problem in tropical countries, may present severe clinical manifestations as result of increased vascular permeability and coagulation disorders. Dengue virus (DENV), detected in peripheral monocytes during acute disease and in in vitro infection, leads to cytokine production, indicating that virus-target cell interactions are relevant to pathogenesis. Here we investigated the in vitro and in vivo activation of human peripheral monocytes after DENV infection. The numbers of CD14(+) monocytes expressing the adhesion molecule intercellular adhesion molecule 1 (ICAM-1) were significantly increased during acute DF. A reduced number of CD14(+) human leucocyte antigen (HLA)-DR(+) monocytes was observed in patients with severe dengue when compared to those with mild dengue and controls; CD14(+) monocytes expressing toll-like receptor (TLR)2 and TLR4 were increased in peripheral blood from dengue patients with mild disease, but in vitro DENV-2 infection up-regulated only TLR2. Increased numbers of CD14(+) CD16(+) activated monocytes were found after in vitro and in vivo DENV-2 infection. The CD14(high) CD16(+) monocyte subset was significantly expanded in mild dengue, but not in severe dengue. Increased plasma levels of tumour necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma) and interleukin (IL)-18 in dengue patients were inversely associated with CD14(high) CD16(+), indicating that these cells might be involved in controlling exacerbated inflammatory responses, probably by IL-10 production. We showed here, for the first time, phenotypic changes on peripheral monocytes that were characteristic of cell activation. A sequential monocyte-activation model is proposed in which DENV infection triggers TLR2/4 expression and inflammatory cytokine production, leading eventually to haemorrhagic manifestations, thrombocytopenia, coagulation disorders, plasmatic leakage and shock development, but may also produce factors that act in order to control both intense immunoactivation and virus replication.

Published
2010

25. Stratifying Minimal Versus Severe Pain in Knee Osteoarthritis Using a Musculoskeletal Ultrasound Protocol.

Author

Bernardo‐Bueno, Mary Monica, Gonzalez‐Suarez, Consuelo B., Malvar, Andrea Kristina, Cua, Ronald, Feliciano, Daniel, Tan‐Sales, Bee Giok, Aycardo, Svetlana Maris O., Tan‐Ong, Millicent, Chan, Robert, and De Los Reyes, Francisco

Subjects
KNEE pain, OSTEOARTHRITIS, ULTRASONIC imaging, BONE spurs, JOINT pain
Abstract

Objective: The aim of this cross‐sectional correlational study was to determine the association of pain with morphologic and inflammatory sonographic findings in patients with knee osteoarthritis. Methods: A total of 113 participants with knee osteoarthritis were assessed using visual analog scale pain score and sonography. Ultrasound evaluation included morphologic changes (ie, articular cartilage degeneration, medial and lateral meniscal protrusion, and presence of osteophytes on the joint margins) and inflammatory changes (ie suprapatellar effusion and/or synovitis, Baker cyst, superficial and deep infrapatellar effusion, pes anserine tendinopathy, and Hoffa panniculitis). Results: Cluster analysis via Ward's method grouped patients with minimal pain (visual analog scale score, 0–4) and with substantial pain (visual analog scale score, 5–10). Stepwise logistic regression yielded 5 variables that significantly explained the variation in the probability of perceived substantial pain at 10% level of significance: lateral cartilage clarity (LCC; P = .025), medial cartilage clarity (MCC; P = .20), medial cartilage thickness (MCT; P = .041), medial meniscus protrusion (MMP) (P = .029), and osteophytes at medial femoral margin (P = .082), with 63% overall prediction accuracy. When age and sex were added, 4 variables remained significant at a 10% level of significance: LCC, MCC, MCT, and MMP, with 65% overall prediction accuracy. The receiver operating characteristic curve of this model was 0.667. Conclusion: The study was able to demonstrate that morphologic abnormalities in the ultrasound parameters for LCC, MCC, MCT, and MMP were able to predict significant joint pain in knee osteoarthritis. There were no inflammatory changes that contributed to significant joint pain in this study. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
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26. Sociodemographic and Obstetric Risk Factors for Postpartum Depressive Symptoms in Nigerian Women

Author

Fatoye Fo, Bola A. Ola, Stella-Maris O. Ibigbami, Abiodun O. Adewuya, and Omowumi R. Ijaodola

Subjects
Adult, endocrine system, medicine.medical_specialty, Obstetric risk, Nigeria, Depression, Postpartum, Pregnancy, Risk Factors, mental disorders, Prevalence, medicine, Humans, Psychiatry, reproductive and urinary physiology, Depression (differential diagnoses), Depressive symptoms, Psychiatric Status Rating Scales, business.industry, Length of Stay, Delivery, Obstetric, female genital diseases and pregnancy complications, Parity, Cross-Sectional Studies, Social Class, Edinburgh Postnatal Depression Scale, Female, business, Psychosocial
Abstract

Studies from the Western culture have emphasized psychosocial risk factors for the development of postnatal depression (PND). In Africa, poor obstetrics practice and sociodemographic factors may contribute significantly to the risk of PND. The goal of this study was to examine sociodemographic and obstetric risk factors for postnatal depressive symptoms in a Nigerian community.876 women recruited at 6 weeks postpartum from the postnatal and infant immunization clinics of 5 participating health centers were screened with the Edinburgh Postnatal Depression Scale (EPDS). Sociodemographic and obstetric information were also obtained through a structured questionnaire.The mean EPDS score was 5.66 (SD = 4.20). Depression was diagnosed in 128 (14.6 %) of the postpartum women. The predictors of PND include hospital admissions during the pregnancy (OR 3.95, CI 2.57-6.07), female sex of the baby (OR 2.74, CI 1.87-4.03), preterm delivery (OR 4.21, CI 2.78-6.39), instrumental delivery (OR 3.32, CI 1.79-6.16), Cesarean section (OR 3.58, CI 1.72-7.48), and being single (OR 3.44, CI 2.15-5.53).Although the prevalence of PND symptoms seems to be the same across cultures, risk factors differ significantly. This study identified certain sociodemographic and obstetric risk factors for postnatal depressive symptoms in an underdeveloped community. These factors must be taken into consideration when planning intervention and preventive strategies for these women.

Published
2005

27. The prototype detection unit of the KM3NeT detector

Author

Adrian-Martinez, S., Ageron, M., Aharonian, F., Aiello, S., Albert, A., Ameli, F., Anassontzis, E., Androulakis, G., Anghinolfi, M., Anton, G., Anvar, S., Ardid, M., Avgitas, T., Balasi, K., Band, H., Barbarino, G., Barbarito, E., Barbato, F., Baret, B., Baron, S., Barrios, J., Belias, A., Berbee, E., van den Berg, A., Berkien, A., Bertin, V., Beurthey, S., van Beveren, V., Beverini, N., Biagi, S., Biagioni, A., Bianucci, S., Billault, M., Birbas, A., Rookhuizen, H., Bormuth, R., Bouche, V., Bouhadef, B., Bourlis, G., Boutonnet, C., Bouwhuis, M., Bozza, C., Bruijn, R., Brunner, J., Cacopardo, G., Caillat, L., Calamai, M., Calvo, D., Capone, A., Caramete, L., Caruso, F., Cecchini, S., Ceres, A., Cereseto, R., Champion, C., Chateau, F., Chiarusi, T., Christopoulou, B., Circella, M., Classen, L., Cocimano, R., Coleiro, A., Colonges, S., Coniglione, R., Cosquer, A., Costa, M., Coyle, P., Creusot, A., Cuttone, G., D'Amato, C., D'Amico, A., De Bonis, G., De Rosa, G., Deniskina, N., Destelle, J., Distefano, C., Di Capua, F., Donzaud, C., Dornic, D., Dorosti-Hasankiadeh, Q., Drakopoulou, E., Drouhin, D., Drury, L., Durand, D., Eberl, T., Elsaesser, D., Enzenhoefer, A., Fermani, P., Fusco, L., Gajanana, D., Gal, T., Galata, S., Garufi, F., Gebyehu, M., Giordano, V., Gizani, N., Ruiz, R., Graf, K., Grasso, R., Grella, G., Grmek, A., Habel, R., van Haren, H., Heid, T., Heijboer, A., Heine, E., Henry, S., Hernandez-Rey, J., Herold, B., Hevinga, M., van der Hoek, M., Hofestaedt, J., Hogenbirk, J., Hugon, C., Hoessl, J., Imbesi, M., James, Clancy, Jansweijer, P., Jochum, J., de Jong, M., Jongen, M., Kadler, M., Kalekin, O., Kappes, A., Kappos, E., Katz, U., Kavatsyuk, O., Keller, P., Kieft, G., Koffeman, E., Kok, H., Kooijman, P., Koopstra, J., Korporaal, A., Kouchner, A., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Lamare, P., Larosa, G., Lattuada, D., Le Provost, H., Leismueller, K., Leisos, A., Lenis, D., Leonora, E., Clark, M., Llorens Alvarez, C., Lohner, H., Lonardo, A., Loucatos, S., Louis, F., Maccioni, E., Mannheim, K., Manolopoulos, K., Margiotta, A., Maris, O., Markou, C., Martinez-Mora, J., Martini, A., Masullo, R., Melis, K., Michael, T., Migliozzi, P., Migneco, E., Miraglia, A., Mollo, C., Mongelli, M., Morganti, M., Mos, S., Moudden, Y., Musico, P., Musumeci, M., Nicolaou, C., Nicolau, C., Orlando, A., Orzelli, A., Papaikonomou, A., Papaleo, R., Pavalas, G., Peek, H., Pellegrino, C., Pellegriti, M., Perrina, C., Piattelli, P., Pikounis, K., Popa, V., Pradier, T., Priede, M., Puehlhofer, G., Pulvirenti, S., Racca, C., Raffaelli, F., Randazzo, N., Rapidis, P., Razis, P., Real, D., Resvanis, L., Reubelt, J., Riccobene, G., Rovelli, A., Saldana, M., Samtleben, D., Sanguineti, M., Santangelo, A., Sapienza, P., Schmelling, J., Schnabel, J., Sciacca, V., Sedita, M., Seitz, T., Sgura, I., Simeone, F., Sipala, V., Spitaleri, A., Spurio, M., Stavropoulos, G., Steijger, J., Stolarczyk, T., Stransky, D., Taiuti, M., Terreni, G., Tezier, D., Theraube, S., Thompson, L., Timmer, P., Trasatti, L., Trovato, A., Tselengidou, M., Tsirigotis, A., Tzamarias, S., Tzamariudaki, E., Vallage, B., Van Elewyck, V., Vermeulen, J., Vernin, P., Vicini, P., Viola, S., Vivolo, D., Werneke, P., Wiggers, L., Wilms, J., de Wolf, E., van Wooning, R., Zonca, E., Zornoza, J., Zuniga, J., Zwart, A., Adrian-Martinez, S., Ageron, M., Aharonian, F., Aiello, S., Albert, A., Ameli, F., Anassontzis, E., Androulakis, G., Anghinolfi, M., Anton, G., Anvar, S., Ardid, M., Avgitas, T., Balasi, K., Band, H., Barbarino, G., Barbarito, E., Barbato, F., Baret, B., Baron, S., Barrios, J., Belias, A., Berbee, E., van den Berg, A., Berkien, A., Bertin, V., Beurthey, S., van Beveren, V., Beverini, N., Biagi, S., Biagioni, A., Bianucci, S., Billault, M., Birbas, A., Rookhuizen, H., Bormuth, R., Bouche, V., Bouhadef, B., Bourlis, G., Boutonnet, C., Bouwhuis, M., Bozza, C., Bruijn, R., Brunner, J., Cacopardo, G., Caillat, L., Calamai, M., Calvo, D., Capone, A., Caramete, L., Caruso, F., Cecchini, S., Ceres, A., Cereseto, R., Champion, C., Chateau, F., Chiarusi, T., Christopoulou, B., Circella, M., Classen, L., Cocimano, R., Coleiro, A., Colonges, S., Coniglione, R., Cosquer, A., Costa, M., Coyle, P., Creusot, A., Cuttone, G., D'Amato, C., D'Amico, A., De Bonis, G., De Rosa, G., Deniskina, N., Destelle, J., Distefano, C., Di Capua, F., Donzaud, C., Dornic, D., Dorosti-Hasankiadeh, Q., Drakopoulou, E., Drouhin, D., Drury, L., Durand, D., Eberl, T., Elsaesser, D., Enzenhoefer, A., Fermani, P., Fusco, L., Gajanana, D., Gal, T., Galata, S., Garufi, F., Gebyehu, M., Giordano, V., Gizani, N., Ruiz, R., Graf, K., Grasso, R., Grella, G., Grmek, A., Habel, R., van Haren, H., Heid, T., Heijboer, A., Heine, E., Henry, S., Hernandez-Rey, J., Herold, B., Hevinga, M., van der Hoek, M., Hofestaedt, J., Hogenbirk, J., Hugon, C., Hoessl, J., Imbesi, M., James, Clancy, Jansweijer, P., Jochum, J., de Jong, M., Jongen, M., Kadler, M., Kalekin, O., Kappes, A., Kappos, E., Katz, U., Kavatsyuk, O., Keller, P., Kieft, G., Koffeman, E., Kok, H., Kooijman, P., Koopstra, J., Korporaal, A., Kouchner, A., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Lamare, P., Larosa, G., Lattuada, D., Le Provost, H., Leismueller, K., Leisos, A., Lenis, D., Leonora, E., Clark, M., Llorens Alvarez, C., Lohner, H., Lonardo, A., Loucatos, S., Louis, F., Maccioni, E., Mannheim, K., Manolopoulos, K., Margiotta, A., Maris, O., Markou, C., Martinez-Mora, J., Martini, A., Masullo, R., Melis, K., Michael, T., Migliozzi, P., Migneco, E., Miraglia, A., Mollo, C., Mongelli, M., Morganti, M., Mos, S., Moudden, Y., Musico, P., Musumeci, M., Nicolaou, C., Nicolau, C., Orlando, A., Orzelli, A., Papaikonomou, A., Papaleo, R., Pavalas, G., Peek, H., Pellegrino, C., Pellegriti, M., Perrina, C., Piattelli, P., Pikounis, K., Popa, V., Pradier, T., Priede, M., Puehlhofer, G., Pulvirenti, S., Racca, C., Raffaelli, F., Randazzo, N., Rapidis, P., Razis, P., Real, D., Resvanis, L., Reubelt, J., Riccobene, G., Rovelli, A., Saldana, M., Samtleben, D., Sanguineti, M., Santangelo, A., Sapienza, P., Schmelling, J., Schnabel, J., Sciacca, V., Sedita, M., Seitz, T., Sgura, I., Simeone, F., Sipala, V., Spitaleri, A., Spurio, M., Stavropoulos, G., Steijger, J., Stolarczyk, T., Stransky, D., Taiuti, M., Terreni, G., Tezier, D., Theraube, S., Thompson, L., Timmer, P., Trasatti, L., Trovato, A., Tselengidou, M., Tsirigotis, A., Tzamarias, S., Tzamariudaki, E., Vallage, B., Van Elewyck, V., Vermeulen, J., Vernin, P., Vicini, P., Viola, S., Vivolo, D., Werneke, P., Wiggers, L., Wilms, J., de Wolf, E., van Wooning, R., Zonca, E., Zornoza, J., Zuniga, J., and Zwart, A.

Published
2016

28. A method to stabilise the performance of negatively fed KM3NeT photomultipliers

Author

Adrian-Martinez, S., Ageron, M., Aiello, S., Albert, A., Ameli, F., Anassontzis, E., Andre, M., Androulakis, G., Anghinolfi, M., Anton, G., Ardid, M., Avgitas, T., Barbarino, G., Barbarito, E., Baret, B., Barrios-Marti, J., Belias, A., Berbee, E., van den Berg, A., Bertin, V., Beurthey, S., van Beveren, V., Beverini, N., Biagi, S., Biagioni, A., Billault, M., Bondi, M., Bormuth, R., Bouhadef, B., Bourlis, G., Bourret, S., Boutonnet, C., Bouwhuis, M., Bozza, C., Bruijn, R., Brunner, J., Buis, E., Buompane, R., Busto, J., Cacopardo, G., Caillat, L., Calamai, M., Calvo, D., Capone, A., Caramete, L., Cecchini, S., Celli, S., Champion, C., Cherubini, S., Chiarella, V., Chiarelli, L., Chiarusi, T., Circella, M., Classen, L., Cobas, D., Cocimano, R., Coelho, J., Coleiro, A., Colonges, S., Coniglione, R., Cordelli, M., Cosquer, A., Coyle, P., Creusot, A., Cuttone, G., D'Amato, C., D'Amico, A., D'Onofrio, A., De Bonis, G., De Sio, C., Di Capua, F., Di Palma, I., Distefano, C., Donzaud, C., Dornic, D., Dorosti-Hasankiadeh, Q., Drakopoulou, E., Drouhin, D., Durocher, M., Eberl, T., Eichie, S., van Eijk, D., El Bojaddaini, I., Elsaesser, D., Enzenhofer, A., Favaro, M., Fermani, P., Ferrara, G., Frascadore, G., Furini, M., Fusco, L., Gal, T., Galata, S., Garufi, F., Gay, P., Gebyehu, M., Giacomini, F., Gialanella, L., Giordano, V., Gizani, N., Gracia, R., Graf, K., Gregoire, T., Grella, G., Grmek, A., Guerzoni, M., Habel, R., Hallmann, S., van Haren, H., Harissopulos, S., Heid, T., Heijboer, A., Heine, E., Henry, S., Hernandez-Rey, J., Hevinga, M., Hofestaedt, J., Hugon, C., Illuminati, G., James, Clancy, Jansweijer, P., Jongen, M., de Jong, M., Kadler, M., Kalekin, O., Kappes, A., Katz, U., Keller, P., Kieft, G., Kiessling, D., Koffeman, E., Kooijman, P., Kouchner, A., Kreter, M., Kulikovskiy, V., Lahmann, R., Lamare, P., Leisos, A., Leonora, J., Clark, M., Liolios, A., Llorens Alvarez, C., Lo Presti, D., Lohner, H., Lonardo, A., Lotze, M., Loucatos, S., Maccioni, E., Mannheim, K., Manzali, M., Margiotta, A., Margotti, A., Marinelli, A., Maris, O., Markou, C., Martinez-Mora, J., Martini, A., Marzaioli, F., Mele, R., Melis, K., Michael, T., Migliozzi, P., Migneco, E., Mijakowski, P., Miraglia, A., Mollo, C., Mongelli, M., Morganti, M., Moussa, A., Musico, P., Musumeci, M., Nicolau, C., Olcina, I., Olivetto, C., Orlando, A., Orzelli, A., Pancaldi, G., Paolucci, A., Papaikonomou, A., Papaleo, R., Pavalas, G., Peek, H., Pellegrini, G., Pellegrino, C., Perrina, C., Pfutzner, M., Piattelli, P., Pikounis, K., Poma, G., Popa, V., Pradier, T., Pratolongo, F., Puehlhofer, G., Pulvirenti, S., Quinn, L., Racca, C., Raffaelli, F., Randazzo, N., Real, D., Resvanis, L., Reubelt, J., Riccobene, G., Rossi, C., Rovelli, A., Saldana, M., Salvadori, I., Samtleben, D., Garcia, A., Losa, A., Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schimmel, F., Schmelling, J., Schnabel, J., Sciacca, V., Sedita, M., Seitz, T., Sgura, I., Simeone, F., Sipala, V., Spisso, B., Spurio, M., Stavropoulos, G., Steijger, J., Stellacci, S., Stransky, D., Taiuti, M., Tayalati, Y., Terrasi, F., Tezier, D., Theraube, S., Timmer, P., Tonnis, C., Trasatti, L., Travaglini, R., Trovato, A., Tsirigotis, A., Tzamarias, S., Tzamariudaki, E., Vallage, B., Van Elewyck, V., Vermeulen, J., Versari, F., Vicini, P., Viola, S., Vivolo, D., Volkert, M., Wiggers, L., Wilms, J., de Wolf, E., Zachariadou, K., Zani, S., Zornoza, J., Zuniga, J., Adrian-Martinez, S., Ageron, M., Aiello, S., Albert, A., Ameli, F., Anassontzis, E., Andre, M., Androulakis, G., Anghinolfi, M., Anton, G., Ardid, M., Avgitas, T., Barbarino, G., Barbarito, E., Baret, B., Barrios-Marti, J., Belias, A., Berbee, E., van den Berg, A., Bertin, V., Beurthey, S., van Beveren, V., Beverini, N., Biagi, S., Biagioni, A., Billault, M., Bondi, M., Bormuth, R., Bouhadef, B., Bourlis, G., Bourret, S., Boutonnet, C., Bouwhuis, M., Bozza, C., Bruijn, R., Brunner, J., Buis, E., Buompane, R., Busto, J., Cacopardo, G., Caillat, L., Calamai, M., Calvo, D., Capone, A., Caramete, L., Cecchini, S., Celli, S., Champion, C., Cherubini, S., Chiarella, V., Chiarelli, L., Chiarusi, T., Circella, M., Classen, L., Cobas, D., Cocimano, R., Coelho, J., Coleiro, A., Colonges, S., Coniglione, R., Cordelli, M., Cosquer, A., Coyle, P., Creusot, A., Cuttone, G., D'Amato, C., D'Amico, A., D'Onofrio, A., De Bonis, G., De Sio, C., Di Capua, F., Di Palma, I., Distefano, C., Donzaud, C., Dornic, D., Dorosti-Hasankiadeh, Q., Drakopoulou, E., Drouhin, D., Durocher, M., Eberl, T., Eichie, S., van Eijk, D., El Bojaddaini, I., Elsaesser, D., Enzenhofer, A., Favaro, M., Fermani, P., Ferrara, G., Frascadore, G., Furini, M., Fusco, L., Gal, T., Galata, S., Garufi, F., Gay, P., Gebyehu, M., Giacomini, F., Gialanella, L., Giordano, V., Gizani, N., Gracia, R., Graf, K., Gregoire, T., Grella, G., Grmek, A., Guerzoni, M., Habel, R., Hallmann, S., van Haren, H., Harissopulos, S., Heid, T., Heijboer, A., Heine, E., Henry, S., Hernandez-Rey, J., Hevinga, M., Hofestaedt, J., Hugon, C., Illuminati, G., James, Clancy, Jansweijer, P., Jongen, M., de Jong, M., Kadler, M., Kalekin, O., Kappes, A., Katz, U., Keller, P., Kieft, G., Kiessling, D., Koffeman, E., Kooijman, P., Kouchner, A., Kreter, M., Kulikovskiy, V., Lahmann, R., Lamare, P., Leisos, A., Leonora, J., Clark, M., Liolios, A., Llorens Alvarez, C., Lo Presti, D., Lohner, H., Lonardo, A., Lotze, M., Loucatos, S., Maccioni, E., Mannheim, K., Manzali, M., Margiotta, A., Margotti, A., Marinelli, A., Maris, O., Markou, C., Martinez-Mora, J., Martini, A., Marzaioli, F., Mele, R., Melis, K., Michael, T., Migliozzi, P., Migneco, E., Mijakowski, P., Miraglia, A., Mollo, C., Mongelli, M., Morganti, M., Moussa, A., Musico, P., Musumeci, M., Nicolau, C., Olcina, I., Olivetto, C., Orlando, A., Orzelli, A., Pancaldi, G., Paolucci, A., Papaikonomou, A., Papaleo, R., Pavalas, G., Peek, H., Pellegrini, G., Pellegrino, C., Perrina, C., Pfutzner, M., Piattelli, P., Pikounis, K., Poma, G., Popa, V., Pradier, T., Pratolongo, F., Puehlhofer, G., Pulvirenti, S., Quinn, L., Racca, C., Raffaelli, F., Randazzo, N., Real, D., Resvanis, L., Reubelt, J., Riccobene, G., Rossi, C., Rovelli, A., Saldana, M., Salvadori, I., Samtleben, D., Garcia, A., Losa, A., Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schimmel, F., Schmelling, J., Schnabel, J., Sciacca, V., Sedita, M., Seitz, T., Sgura, I., Simeone, F., Sipala, V., Spisso, B., Spurio, M., Stavropoulos, G., Steijger, J., Stellacci, S., Stransky, D., Taiuti, M., Tayalati, Y., Terrasi, F., Tezier, D., Theraube, S., Timmer, P., Tonnis, C., Trasatti, L., Travaglini, R., Trovato, A., Tsirigotis, A., Tzamarias, S., Tzamariudaki, E., Vallage, B., Van Elewyck, V., Vermeulen, J., Versari, F., Vicini, P., Viola, S., Vivolo, D., Volkert, M., Wiggers, L., Wilms, J., de Wolf, E., Zachariadou, K., Zani, S., Zornoza, J., and Zuniga, J.

Published
2016

29. Economics of the Nine Year Universal Basic Education in Nigeria: Major Issues and Implications

Author

Undie, JA, Obasi, FN, Ubom, B, and Stella-Maris, O

Abstract

We reviewed the historical background of Universal Basic Education (UBE), with a focus on its economics and requirements for the successful execution of the scheme. The economic rationalization of the scheme was examined on the basis of a number of issues such as the Universality of UBE, education, fear of eventual under funding etc. Recommendations were made for the sustainability of the scheme.

Published
2013

30. Expansion cone for the 3-inch PMTs of the KM3NeT optical modules

Author

Adrian-Martinez, S. Ageron, M. Aguilar, J.A. Aharonian, F. Aiello, S. Albert, A. Alexandri, M. Ameli, M. Anassontzis, E.G. Anghinolfi, M. Anton, G. Anvar, S. Ardid, M. Assis Jesus, A. Aubert, J.-J. Bakker, R. Ball, A.E. Barbarino, G. Barbarito, E. Barbato, F. Baret, B. De Bel, M. Belias, A. Bellou, N. Berbee, E. Berkien, A. Bersani, A. Bertin, V. Beurthey, S. Biagi, S. Bigongiari, C. Bigourdan, B. Billault, M. De Boer, R. Boer Rookhuizen, H. Bonori, M. Borghini, M. Bou-Cabo, M. Bouhadef, B. Bourlis, G. Bouwhuis, M. Bradbury, S. Brown, A. Bruni, F. Brunner, J. Brunoldi, M. Busto, J. Cacopardo, G. Caillat, L. Calvo Díaz-Aldagalán, D. Calzas, A. Canals, M. Capone, A. Carr, J. Castorina, E. Cecchini, S. Ceres, A. Cereseto, R. Chaleil, Th. Chateau, F. Chiarusi, T. Choqueuse, D. Christopoulou, P.E. Chronis, G. Ciaffoni, O. Circella, M. Cocimano, R. Cohen, F. Colijn, F. Coniglione, R. Cordelli, M. Cosquer, A. Costa, M. Coyle, P. Craig, J. Creusot, A. Curtil, C. D'Amico, A. Damy, G. De Asmundis, R. De Bonis, G. Decock, G. Decowski, P. Delagnes, E. De Rosa, G. Distefano, C. Donzaud, C. Dornic, D. Dorosti-Hasankiadeh, Q. Drogou, J. Drouhin, D. Druillole, F. Drury, L. Durand, D. Durand, G.A. Eberl, T. Emanuele, U. Enzenhöfer, A. Ernenwein, J.-P. Escoffier, S. Espinosa, V. Etiope, G. Favali, P. Felea, D. Ferri, M. Ferry, S. Flaminio, V. Folger, F. Fotiou, A. Fritsch, U. Gajanana, D. Garaguso, R. Gasparini, G.P. Gasparoni, F. Gautard, V. Gensolen, F. Geyer, K. Giacomelli, G. Gialas, I. Giordano, V. Giraud, J. Gizani, N. Gleixner, A. Gojak, C. Gómez-González, J.P. Graf, K. Grasso, D. Grimaldi, A. Groenewegen, R. Guédé, Z. Guillard, G. Guilloux, F. Habel, R. Hallewell, G. Van Haren, H. Van Heerwaarden, J. Heijboer, A. Heine, E. Hernández-Rey, J.J. Herold, B. Van De Hoek, M. Hogenbirk, J. Hößl, J. Hsu, C.C. Imbesi, M. Jamieson, A. Jansweijer, P. De Jong, M. Jouvenot, F. Kadler, M. Kalantar-Nayestanaki, N. Kalekin, O. Kappes, A. Karolak, M. Katz, U.F. Kavatsyuk, O. Keller, P. Kiskiras, Y. Klein, R. Kok, H. Kontoyiannis, H. Kooijman, P. Koopstra, J. Kopper, C. Korporaal, A. Koske, P. Kouchner, A. Koutsoukos, S. Kreykenbohm, I. Kulikovskiy, V. Laan, M. La Fratta, C. Lagier, P. Lahmann, R. Lamare, P. Larosa, G. Lattuada, D. Leisos, A. Lenis, D. Leonora, E. Le Provost, H. Lim, G. Llorens, C.D. Lloret, J. Löhner, H. Lo Presti, D. Lotrus, P. Louis, F. Lucarelli, F. Lykousis, V. Malyshev, D. Mangano, S. Marcoulaki, E.C. Margiotta, A. Marinaro, G. Marinelli, A. Maris, O. Markopoulos, E. Markou, C. Martínez-Mora, J.A. Martini, A. Marvaldi, J. Masullo, R. Maurin, G. Migliozzi, P. Migneco, E. Minutoli, S. Miraglia, A. Mollo, C.M. Mongelli, M. Monmarthe, E. Morganti, M. Mos, S. Motz, H. Moudden, Y. Mul, G. Musico, P. Musumeci, M. Naumann, Ch. Neff, M. Nicolaou, C. Orlando, A. Palioselitis, D. Papageorgiou, K. Papaikonomou, A. Papaleo, R. Papazoglou, I.A. Pǎvǎlas, G.E. Peek, H.Z. Perkin, J. Piattelli, P. Popa, V. Pradier, T. Presani, E. Priede, I.G. Psallidas, A. Rabouille, C. Racca, C. Radu, A. Randazzo, N. Rapidis P.a. Razis, P. Real, D. Reed, C. Reito, S. Resvanis, L.K. Riccobene, G. Richter, R. Roensch, K. Rolin, J. Rose, J. Roux, J. Rovelli, A. Russo, A. Russo, G.V. Salesa, F. Samtleben, D. Sapienza, P. Schmelling, J.-W. Schmid, J. Schnabel, J. Schroeder, K. Schuller, J.-P. Schussler, F. Sciliberto, D. Sedita, M. Seitz, T. Shanidze, R. Simeone, F. Siotis, I. Sipala, V. Sollima, C. Sparnocchia, S. Spies, A. Spurio, M. Staller, T. Stavrakakis, S. Stavropoulos, G. Steijger, J. Stolarczyk, Th. Stransky, D. Taiuti, M. Taylor, A. Thompson, L. Timmer, P. Tonoiu, D. Toscano, S. Touramanis, C. Trasatti, L. Traverso, P. Trovato, A. Tsirigotis, A. Tzamarias, S. Tzamariudaki, E. Urbano, F. Vallage, B. Van Elewyck, V. Vannoni, G. Vecchi, M. Vernin, P. Viola, S. Vivolo, D. Wagner, S. Werneke, P. White, R.J. Wijnker, G. Wilms, J. De Wolf, E. Yepes, H. Zhukov, V. Zonca, E. Zornoza, J.D. Zúñiga, J.

Subjects
Physics::Instrumentation and Detectors, Astrophysics::Instrumentation and Methods for Astrophysics
Abstract

Detection of high-energy neutrinos from distant astrophysical sources will open a new window on the Universe. The detection principle exploits the measurement of Cherenkov light emitted by charged particles resulting from neutrino interactions in the matter containing the telescope. A novel multi-PMT digital optical module (DOM) was developed to contain 31 3-inch photomultiplier tubes (PMTs). In order to maximize the detector sensitivity, each PMT will be surrounded by an expansion cone which collects photons that would otherwise miss the photocathode. Results for various angles of incidence with respect to the PMT surface indicate an increase in collection efficiency by 30% on average for angles up to 45° with respect to the perpendicular. Ray-tracing calculations could reproduce the measurements, allowing to estimate an increase in the overall photocathode sensitivity, integrated over all angles of incidence, by 27% (for a single PMT). Prototype DOMs, being built by the KM3NeT consortium, will be equipped with these expansion cones.© 2013 IOP Publishing Ltd and Sissa Medialab srl.

Published
2013

31. Differential regulation of toll-like receptor-2, toll-like receptor-4, CD16 and human leucocyte antigen-DR on peripheral blood monocytes during mild and severe dengue fever

Author

Elzinandes L, Azeredo, Patrícia C, Neves-Souza, Allan R, Alvarenga, Sônia R N I, Reis, Amanda, Torrentes-Carvalho, Sonia-Maris O, Zagne, Rita M R, Nogueira, Luzia M, Oliveira-Pinto, and Claire F, Kubelka

Subjects
Adult, Male, Adolescent, Lipopolysaccharide Receptors, GPI-Linked Proteins, Virus Replication, Severity of Illness Index, Monocytes, Cell Line, Dengue, Interferon-gamma, Animals, Humans, Aged, Tumor Necrosis Factor-alpha, Receptors, IgG, Interleukin-18, HLA-DR Antigens, Original Articles, Dengue Virus, Middle Aged, Intercellular Adhesion Molecule-1, Toll-Like Receptor 2, Interleukin-10, Toll-Like Receptor 4, Gene Expression Regulation, Acute Disease, Female
Abstract

Dengue fever (DF), a public health problem in tropical countries, may present severe clinical manifestations as result of increased vascular permeability and coagulation disorders. Dengue virus (DENV), detected in peripheral monocytes during acute disease and in in vitro infection, leads to cytokine production, indicating that virus-target cell interactions are relevant to pathogenesis. Here we investigated the in vitro and in vivo activation of human peripheral monocytes after DENV infection. The numbers of CD14(+) monocytes expressing the adhesion molecule intercellular adhesion molecule 1 (ICAM-1) were significantly increased during acute DF. A reduced number of CD14(+) human leucocyte antigen (HLA)-DR(+) monocytes was observed in patients with severe dengue when compared to those with mild dengue and controls; CD14(+) monocytes expressing toll-like receptor (TLR)2 and TLR4 were increased in peripheral blood from dengue patients with mild disease, but in vitro DENV-2 infection up-regulated only TLR2. Increased numbers of CD14(+) CD16(+) activated monocytes were found after in vitro and in vivo DENV-2 infection. The CD14(high) CD16(+) monocyte subset was significantly expanded in mild dengue, but not in severe dengue. Increased plasma levels of tumour necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma) and interleukin (IL)-18 in dengue patients were inversely associated with CD14(high) CD16(+), indicating that these cells might be involved in controlling exacerbated inflammatory responses, probably by IL-10 production. We showed here, for the first time, phenotypic changes on peripheral monocytes that were characteristic of cell activation. A sequential monocyte-activation model is proposed in which DENV infection triggers TLR2/4 expression and inflammatory cytokine production, leading eventually to haemorrhagic manifestations, thrombocytopenia, coagulation disorders, plasmatic leakage and shock development, but may also produce factors that act in order to control both intense immunoactivation and virus replication.

Published
2010

32. KM3NeT: Technical design report

Author

Km, The Net Consortium, Bagley, P., Craig, J., Holford, A., Jamieson, A., Niedzielski, T., Priede, I. G., Bell, M., Koopstra, J., Lim, G., Wolf, E., Baret, B., Donzaud, C., Kouchner, A., Elewyck, V., Anassontzis, E. G., Resvanis, L. K., Anvar, S., Chateau, F., Chaleil, T. H., Decock, G., Delagnes, E., Druillole, F., Durand, D., Gautard, V., Giraud, J., Grenier, I., Guilloux, F., Karolak, M., Kestener, P., Lamare, P., Le Provost, H., Lotrus, P., Loucatos, S., Louis, F., Maurin, G., Monmarthe, E., Moscoso, L., Naumann, C. H., Schuller, J. ‐. P., Schussler, F., Stolarczyk, T. H., Vallage, B., Vannoni, G., Vernin, P., Zonca, E., Rabouille, C., Bacciola, D., Borghini, M., Fassin, M., Gasparini, G. P., Schroeder, K., Sparnocchia, S., Traverso, P., Ageron, M., Aubert, J. ‐. J., Bertin, V., Beurthey, S., Billault, M., Brown, A., Brunner, J., Busto, J., Caillat, L., Calzas, A., Carr, J., Cosquer, A., Coyle, P., Curtil, C., Dornic, D., Ernenwein, J. ‐. P., Escoffier, S., Gensolen, F., Gojak, C., Hallewell, G., Keller, P., Lagier, P., Payre, P., Roux, J., Aguilar, J. A., Bernabeu‐verdú, J., Gómez, J. P., Hernández‐rey, J. J., Mangano, S., Real, D., Salesa, F., Toscano, S., Urbano, F., Zornoza, J. D., Nicolaou, C., Razis, P., Aharonian, F., Delaney, S., Drury, L., Gabici, S., Hooper, A., Malishev, D., Taylor, A., Anton, G., Auer, R., Eberl, T., Enzenhöfer, A., Fehr, F., Folger, F., Fritsch, U., Geyer, K., Graf, K., Herold, B., Höβl, J., Kadler, M., Kalekin, O., Kappes, A., Katz, U. F., Klein, R., Kopper, C., Kreykenbohm, I., Kuch, S., Lahmann, R., Motz, H., Neff, M., Richardt, C., Richter, R., Roensch, K., Schöck, F., Seitz, T., Shanidze, R., Spies, A., Wagner, S., Wilms, J., Albert, A., Cohen, F., Racca, C., Stubert‐drouhin, D., Alexandri, M., Chronis, G., Kontoyiannis, H., Lykousis, V., Stavrakakis, S., Bourlis, G., Christopoulou, P. E., Gialas, I., Gizani, N., Leisos, A., Papageorgiou, C., Tsirigotis, A., Tzamarias, S., Barbarito, E., Ceres, A., Circella, M., Mongelli, M., Romita, M., Bazzotti, M., Biagi, S., Carminati, G., Cecchini, S., Chiarusi, T., Giacomelli, G., Margiotta, A., Spurio, M., Aiello, S., Caponetto, L., Grimaldi, A., Leonora, E., Lo Presti, D., Randazzo, N., Reito, S., Russo, G. V., Sciliberto, D., Sipala, V., Urso, S., Anghinolfi, M., Bersani, A., Battaglieri, M., Brunoldi, M., Cereseto, R., Devita, R., Costantini, H., Fratini, K., Minutoli, S., Musico, P., Osipenko, M., Piombo, D., Ricco, G., Ripani, M., Taiuti, M., Torazza, D., Amore, I., Cacopardo, G., Cocimano, R., Coniglione, R., Costa, M., D’amico, A., Distefano, C., Giordano, V., Imbesi, M., Lattuada, D., Migneco, E., Musumeci, M., Orlando, A., Papaleo, R., Pappalardo, V., Piattelli, P., Raia, G., Riccobene, G., Rovelli, A., Sapienza, P., Sedita, M., Trovato, A., Viola, S., Habel, R., Martini, A., Trasatti, L., Barbarino, G., Rosa, G., Russo, S., Castorina, E., Flaminio, V., Garaguso, R., Grasso, D., Marinelli, A., Morganti, M., Sollima, C., Ameli, F., Bonori, Maurizio, Antonio Capone, Bonis, Giulia, Lucarelli, Fabrizio, Masullo, Rocco, Simeone, Francesco, Vecchi, Manuela, Bigourdan, B., Bouquet, P., Choqueuse, D., Damy, G., Drogou, J., Guédé, Z., Marvaldi, J., Rolin, J., Valdy, P., Etiope, G., Favali, P., La Fratta, C., Marinaro, G., Guillard, G., Pradier, T., Felea, D., Maris, O., Pavalas, G., Popa, V., Radu, A., Rujoiu, M., Tonoiu, D., Bellou, N., Colijn, F., Koske, P., Staller, T., Kalantar‐nayestanaki, N., Kavatsyuk, O., Lšhner, H., Bradbury, S., Rose, J., White, R. J., Jouvenot, F., Touramanis, C., Lenis, D., Marcoulaki, E. C., Markou, C., Papazoglou, I. A., Rapidis, P. A., Siotis, I., Tzamariudaki, E., Assis Jesus, A., Berbee, E., Berkien, A., Boer, R., Boer Rookhuizen, H., Bouwhuis, M., Chen, C., Decowski, P., Gajanana, D., Heijboer, A., Heine, E., Hoek, M., Hogenbirk, J., Jansweijer, P., Jong, M., Kok, H., Korporaal, A., Mos, S., Mul, G., Palioselitis, D., Peek, H., Presani, E., Reed, C., Samtleben, D., Schmelling, J. ‐. W., Steijger, J., Timmer, P., Werneke, P., Wijnker, G., Bakker, R., Groenewegen, R., Haren, H., Hillebrand, T., Heerwaarden, J., Laan, M., Smit, M., Athanasopoulos, T., Ball, A., Belias, A., Fotiou, A., Kiskiras, Y., Kostoglou, A., Koutsoukos, S., Maniatis, M., Markopoulos, E., Psallidas, A., Stavropoulos, G., Tsagli, V., Vermisoglou, G., Zhukov, V., Perkin, J., Thompson, L., Gasparoni, F., Bruni, F., Kendziorra, E., Santangelo, A., Kooijman, P., Bigongiari, C., Emanuele, U., Yepes, H., Zuniga, J., Alba, J., Ardid, M., Bou‐cabo, M., Camarena, F., Espinosa, V., Larosa, G., Martinez‐mora, J., Ramis, J., Redondo, J., and Sanchez‐morcillo, V.

Published
2010

37. Dengue in the State of Rio de Janeiro, Brazil, 1986-1998

Author

Nogueira, Rita Maria R, primary, Miagostovich, Marize P, additional, Schatzmayr, Hermann G, additional, Santos, Flávia B dos, additional, Araújo, Eliane S M de, additional, Filippis, Ana Maria B de, additional, Souza, Rogério V de, additional, Zagne, Sonia Maris O, additional, Nicolai, Cecília, additional, Baran, Mary, additional, and Teixeira Filho, Gualberto, additional

Published
1999
Full Text
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39. KM3NeT. Conceptual Design Report for a Deep-Sea Research Infrastructure Incorporating a Very Large Volume Neutrino Telescope in the Mediterranean Sea

Author

Km, The Net Consortium, Bagley, P., Holford, A., Jamieson, A., Priede, M., Ageron, M., Aubert, J., Bertin, V., Beurthey, S., Billault, M., Brown, A., Brunner, J., Busto, J., Caillat, L., Calzas, A., Carr, J., Cosquer, A., Coyle, P., Icurtil, C., Dornic, D., Escoffier, S., Gensolen, F., Gojak, C., Hallewell, G., Keller, P., Lagier, P., Payre, P., Reed, C., Bruijn, R., Koopstra, J., Lim, G., Wolf, E., Baret, B., Donzaud, C., Kouchner, A., Elewyck, V., Anassontzis, E. G., Resvanis, L. K., Anvar, S., Ballet, J., Chateau, F., Delagnes, E., Druillole, F., Durand, D., Grenier, I., Guilloux, F., Kestener, P., Lamare, P., Le Provost, H., Loucatos, S., Louis, F., Maurin, G., Moscoso, L., Naumann, C., Schuller, J. ‐. P., Stolarczyk, T., Vallage, B., Vernin, P., Rabouille, C., Baccila, D., Borghini, M., Fassin, M., Gasparini, G., Schroeder, K., Sparnocchia, S., Traverso, P., Aguilar, J. A., Bernabeu‐verdu, J., Hernandez‐rey, J., Real, D., Salesa, F., Toscano, S., Zornoza, J. D., Razis, P., Aharonian, F., Malishev, D., Delaney, S., Drury, L., Gabici, S., Hooper, A., Taylor, A., Anton, G., Auer, R., Eberl, T., Fehr, F., Fritsch, U., Graf, K., Herold, B., Höβl, J., Kalekin, O., Kappes, A., Katz, U. F., Klein, R., Kopper, C., Ikuch, S., Lahmann, R., Millinger, M., Imotz, H., Schöck, F., Shanidze, R., Albert, A., Cohen, F., Ernenwein, J., Stubert‐drouhin, D., Chronis, G., Georgiadou, I., Kontoyiannis, H., Lykousis, V., Papadopoulos, E., Fragoulis, N., Gizani, N., Kalogirou, K., Leisos, A., Tsirigotis, A., Tzamarias, S., Bellotti, R., Circella, M., Megna, R., Ruvo, G., Ruppi, M., Bazzotti, M., Biagi, S., Carminati, G., Cecchini, S., Chiarusi, T., Giacomelli, G., Margiotta, A., Spurio, M., Aiello, S., Caponetto, L., Grimaldi, A., Leonora, E., Lo Presti, D., Randazzo, N., Reito, S., Russo, G. V., Sciliberto, D., Sipala, V., Urso, S., Anghinolfi, M., Bersani, A., Battaglieri, M., Cereseto, R., Vita, R., Costantini, H., Fratini, K., Minutoli, S., Musico, P., Osipenko, M., Ricco, G., Ripani, M., Taiuti, M., Brunoldi, M., Piombo, D., Torazza, D., Amore, I., Anzalone, A., Cacopardo, G., Cocimano, R., Coniglione, R., D Amico, A., Distefano, C., Migneco, E., Musumeci, M., Orlando, A., Papaleo, R., Pappalardo, V., Piattelli, P., Raia, G., Riccobene, G., Rovelli, A., Sapienza, P., Sedita, M., Habel, R., Martini, A., Trasatti, L., Barbarino, G., Rosa, G., Russo, S., Castorina, E., Flaminio, V., Garaguso, R., Grasso, D., Marinelli, A., Morganti, M., Sollima, C., Ameli, F., Bonori, Maurizio, Antonio Capone, Bonis, Giulia, Lucarelli, Fabrizio, Masullo, Rocco, Simeone, Francesco, Vecchi, Manuela, Bigourdan, B., Bouquet, P., Choqueuse, D., Damy, G., Drogou, J., Guédé, Z., Marvaldi, J., Rolin, J., Valdy, P., Etiope, G., Favali, P., La Fratta, C., Marinaro, G., Lyons, K., Pradier, T., Racca, C., Felea, D., Maris, O., Pavalas, G., Popa, V., Radu, A., Rujoiu, M., Tonoiu, D., Bellou, N., Colijn, F., Koske, P., Staller, T., Kalantar‐nayestanaki, N., Löhner, H., Bradbury, S., Rose, J., White, R. J., Jouvenot, F., Touramanis, C., Kapribanos, P., Lenis, D., Markou, C., Papazoglou, Y., Rapidis, P., Siotis, I., Assis Jesus, A., Boer Rookhuizen, H., Boer, R., Bouwhuis, M., Colnard, C., Decowski, P., Heine, E., Ihogenbirk, J., Hoek, M., Jansweijer, P., Jong, M., Kok, H., Kruijer, L., Mangano, S., Mos, S., Peek, H., Presani, E., Palioselitis, D., Steenhoven, G., Steijger, J., Timmer, P., Werneke, P., Wijnker, G., Haren, H., Smit, M., Anasontzis, S., Athanasopoulos, T., Ball, A., Belias, A., Fotiou, A., Kiskiras, Y., Kostoglou, A., Koutsoukos, S., Maniatis, M., Imarkopoulos, E., Psallidas, A., Stavropoulos, G., Tsagli, V., Vermisoglou, G., Zhukov, V., Perkin, J., Thompson, L., Gasparoni, F., Giacopelli, S., Kooijman, P., Bigongiari, C., Züñiga, J., Alba, J., Ardid, M., Bou‐cabo, M., Camarena, F., Espinosa, V., Martínez‐mora, J., Ramis, J., Redondo, J., and Sánchez‐morcillo, V.

41. SEE tests for commercial off-the-shelf DSPs to be used in a space experiment

Author

Menichelli, M., primary, Alpat, B., additional, Battiston, R., additional, Bizzarri, M., additional, Blasko, S., additional, Burger, J., additional, Caraffini, D., additional, Gil, E.C., additional, Dai, T., additional, Haller, C., additional, Kounine, A., additional, Maris, O., additional, Papi, A., additional, Plyaskine, V., additional, Schartd, D., additional, Simon, R.S., additional, and Steuer, M., additional

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46. Letter of intent for KM3NeT 2.0

Author

S Adrián-Martínez, M Ageron, F Aharonian, S Aiello, A Albert, F Ameli, E Anassontzis, M Andre, G Androulakis, M Anghinolfi, G Anton, M Ardid, T Avgitas, G Barbarino, E Barbarito, B Baret, J Barrios-Martí, B Belhorma, A Belias, E Berbee, A van den Berg, V Bertin, S Beurthey, V van Beveren, N Beverini, S Biagi, A Biagioni, M Billault, M Bondì, R Bormuth, B Bouhadef, G Bourlis, S Bourret, C Boutonnet, M Bouwhuis, C Bozza, R Bruijn, J Brunner, E Buis, J Busto, G Cacopardo, L Caillat, M Calamai, D Calvo, A Capone, L Caramete, S Cecchini, S Celli, C Champion, R Cherkaoui El Moursli, S Cherubini, T Chiarusi, M Circella, L Classen, R Cocimano, J A B Coelho, A Coleiro, S Colonges, R Coniglione, M Cordelli, A Cosquer, P Coyle, A Creusot, G Cuttone, A D’Amico, G De Bonis, G De Rosa, C De Sio, F Di Capua, I Di Palma, A F Díaz García, C Distefano, C Donzaud, D Dornic, Q Dorosti-Hasankiadeh, E Drakopoulou, D Drouhin, L Drury, M Durocher, T Eberl, S Eichie, D van Eijk, I El Bojaddaini, N El Khayati, D Elsaesser, A Enzenhöfer, F Fassi, P Favali, P Fermani, G Ferrara, C Filippidis, G Frascadore, L A Fusco, T Gal, S Galatà, F Garufi, P Gay, M Gebyehu, V Giordano, N Gizani, R Gracia, K Graf, T Grégoire, G Grella, R Habel, S Hallmann, H van Haren, S Harissopulos, T Heid, A Heijboer, E Heine, S Henry, J J Hernández-Rey, M Hevinga, J Hofestädt, C M F Hugon, G Illuminati, C W James, P Jansweijer, M Jongen, M de Jong, M Kadler, O Kalekin, A Kappes, U F Katz, P Keller, G Kieft, D Kießling, E N Koffeman, P Kooijman, A Kouchner, V Kulikovskiy, R Lahmann, P Lamare, A Leisos, E Leonora, M Lindsey Clark, A Liolios, C D Llorens Alvarez, D Lo Presti, H Löhner, A Lonardo, M Lotze, S Loucatos, E Maccioni, K Mannheim, A Margiotta, A Marinelli, O Mariş, C Markou, J A Martínez-Mora, A Martini, R Mele, K W Melis, T Michael, P Migliozzi, E Migneco, P Mijakowski, A Miraglia, C M Mollo, M Mongelli, M Morganti, A Moussa, P Musico, M Musumeci, S Navas, C A Nicolau, I Olcina, C Olivetto, A Orlando, A Papaikonomou, R Papaleo, G E Păvălaş, H Peek, C Pellegrino, C Perrina, M Pfutzner, P Piattelli, K Pikounis, G E Poma, V Popa, T Pradier, F Pratolongo, G Pühlhofer, S Pulvirenti, L Quinn, C Racca, F Raffaelli, N Randazzo, P Rapidis, P Razis, D Real, L Resvanis, J Reubelt, G Riccobene, C Rossi, A Rovelli, M Saldaña, I Salvadori, D F E Samtleben, A Sánchez García, A Sánchez Losa, M Sanguineti, A Santangelo, D Santonocito, P Sapienza, F Schimmel, J Schmelling, V Sciacca, M Sedita, T Seitz, I Sgura, F Simeone, I Siotis, V Sipala, B Spisso, M Spurio, G Stavropoulos, J Steijger, S M Stellacci, D Stransky, M Taiuti, Y Tayalati, D Tézier, S Theraube, L Thompson, P Timmer, C Tönnis, L Trasatti, A Trovato, A Tsirigotis, S Tzamarias, E Tzamariudaki, B Vallage, V Van Elewyck, J Vermeulen, P Vicini, S Viola, D Vivolo, M Volkert, G Voulgaris, L Wiggers, J Wilms, E de Wolf, K Zachariadou, J D Zornoza, J Zúñiga, Adrian-Martinez, S., Ageron, M., Aharonian, F., Aiello, S., Albert, A., Ameli, F., Anassontzis, E., Andre, M., Androulakis, G., Anghinolfi, M., Anton, G., Ardid, M., Avgitas, T., Barbarino, G., Barbarito, E., Baret, B., Barrios-Marti, J., Belhorma, B., Belias, A., Berbee, E., Van Den Berg, A., Bertin, V., Beurthey, S., Van Beveren, V., Beverini, N., Biagi, S., Biagioni, A., Billault, M., Bondi, M., Bormuth, R., Bouhadef, B., Bourlis, G., Bourret, S., Boutonnet, C., Bouwhuis, M., Bozza, C., Bruijn, R., Brunner, J., Buis, E., Busto, J., Cacopardo, G., Caillat, L., Calamai, M., Calvo, D., Capone, A., Caramete, L., Cecchini, S., Celli, S., Champion, C., El Moursli, R. C., Cherubini, S., Chiarusi, T., Circella, M., Classen, L., Cocimano, R., Coelho, J. A. B., Coleiro, A., Colonges, S., Coniglione, R., Cordelli, M., Cosquer, A., Coyle, P., Creusot, A., Cuttone, G., D'Amico, A., De Bonis, G., De Rosa, G., De Sio, C., Di Capua, F., Di Palma, I., Diaz Garcia, A. F., Distefano, C., Donzaud, C., Dornic, D., Dorosti-Hasankiadeh, Q., Drakopoulou, E., Drouhin, D., Drury, L., Durocher, M., Eberl, T., Eichie, S., Van Eijk, D., El Bojaddaini, I., El Khayati, N., Elsaesser, D., Enzenhofer, A., Fassi, F., Favali, P., Fermani, P., Ferrara, G., Filippidis, C., Frascadore, G., Fusco, L. A., Gal, T., Galata, S., Garufi, F., Gay, P., Gebyehu, M., Giordano, V., Gizani, N., Gracia, R., Graf, K., Gregoire, T., Grella, G., Habel, R., Hallmann, S., Van Haren, H., Harissopulos, S., Heid, T., Heijboer, A., Heine, E., Henry, S., Hernandez-Rey, J. J., Hevinga, M., Hofestadt, J., Hugon, C. M. F., Illuminati, G., James, C. W., Jansweijer, P., Jongen, M., De Jong, M., Kadler, M., Kalekin, O., Kappes, A., Katz, U. F., Keller, P., Kieft, G., Kiessling, D., Koffeman, E. N., Kooijman, P., Kouchner, A., Kulikovskiy, V., Lahmann, R., Lamare, P., Leisos, A., Leonora, E., Clark, M. L., Liolios, A., Alvarez, C. D. L., Lo Presti, D., Lohner, H., Lonardo, A., Lotze, M., Loucatos, S., Maccioni, E., Mannheim, K., Margiotta, A., Marinelli, A., Maris, O., Markou, C., Martinez-Mora, J. A., Martini, A., Mele, R., Melis, K. W., Michael, T., Migliozzi, P., Migneco, E., Mijakowski, P., Miraglia, A., Mollo, C. M., Mongelli, M., Morganti, M., Moussa, A., Musico, P., Musumeci, M., Navas, S., Nicolau, C. A., Olcina, I., Olivetto, C., Orlando, A., Papaikonomou, A., Papaleo, R., Pavalas, G. E., Peek, H., Pellegrino, C., Perrina, C., Pfutzner, M., Piattelli, P., Pikounis, K., Poma, G. E., Popa, V., Pradier, T., Pratolongo, F., Puhlhofer, G., Pulvirenti, S., Quinn, L., Racca, C., Raffaelli, F., Randazzo, N., Rapidis, P., Razis, P., Real, D., Resvanis, L., Reubelt, J., Riccobene, G., Rossi, C., Rovelli, A., Saldana, M., Salvadori, I., Samtleben, D. F. E., Garcia, A. S., Losa, A. S., Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schimmel, F., Schmelling, J., Sciacca, V., Sedita, M., Seitz, T., Sgura, I., Simeone, F., Siotis, I., Sipala, V., Spisso, B., Spurio, M., Stavropoulos, G., Steijger, J., Stellacci, S. M., Stransky, D., Taiuti, M., Tayalati, Y., Tezier, D., Theraube, S., Thompson, L., Timmer, P., Tonnis, C., Trasatti, L., Trovato, A., Tsirigotis, A., Tzamarias, S., Tzamariudaki, E., Vallage, B., Van Elewyck, V., Vermeulen, J., Vicini, P., Viola, S., Vivolo, D., Volkert, M., Voulgaris, G., Wiggers, L., Wilms, J., De Wolf, E., Zachariadou, K., Zornoza, J. D., Zuniga, J., Research unit Astroparticle Physics, Research unit Nuclear & Hadron Physics, Adrián-Martínez, S., Barrios-Martí, J., Bondì, M., El Moursli, R. Cherkaoui, Coelho, J.A.B., Díaz García, A.F., Enzenhöfer, A., Fusco, L.A., Galatà, S., Grégoire, T., Hernández-Rey, J.J., Hofestädt, J., Hugon, C.M.F., James, C.W., Katz, U.F., Kießling, D., Koffeman, E.N., Clark, M. Lindsey, Alvarez, C.D. Lloren, Löhner, H., Mariş, O., Martínez-Mora, J.A., Melis, K.W., Mollo, C.M., Nicolau, C.A., Pǎvǎlaş, G.E., Poma, G.E., Pühlhofer, G., Saldaña, M., Samtleben, D.F.E., García, A. Sánchez, Losa, A. Sánchez, Stellacci, S.M., Tézier, D., Tönnis, C., Zornoza, J.D., Zúñiga, J., Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Km3NeT Collaboration, Adrián Martínez, S., Barbarino, Giancarlo, Barrios Martí, J., DE ROSA, Gianfranca, DI CAPUA, Francesco, Díaz García, A. F., Dorosti Hasankiadeh, Q., Garufi, Fabio, Hernández Rey, J. J., Alvarez, C. D. Lloren, Martínez Mora, J. A., Mele, Rosa, Pǎvǎlaş, G. E., Vivolo, Daniele, Centre Tecnològic de Vilanova i la Geltrú, Universitat Politècnica de Catalunya. LAB - Laboratori d'Aplicacions Bioacústiques, Gravitation and Astroparticle Physics Amsterdam, Faculty of Science, Other Research IHEF (IoP, FNWI), IoP (FNWI), Adrian-Martinez, S, Ageron, M, Aharonian, F, Aiello, S, Albert, A, Ameli, F, Anassontzis, E, Andre, M, Androulakis, G, Anghinolfi, M, Anton, G, Ardid, M, Avgitas, T, Barbarino, G, Barbarito, E, Baret, B, Barrios-Marti, J, Belhorma, B, Belias, A, Berbee, E, van den Berg, A, Bertin, V, Beurthey, S, van Beveren, V, Beverini, N, Biagi, S, Biagioni, A, Billault, M, Bondi, M, Bormuth, R, Bouhadef, B, Bourlis, G, Bourret, S, Boutonnet, C, Bouwhuis, M, Bozza, C, Bruijn, R, Brunner, J, Buis, E, Busto, J, Cacopardo, G, Caillat, L, Calamai, M, Calvo, D, Capone, A, Caramete, L, Cecchini, S, Celli, S, Champion, C, El Moursli, Rc, Cherubini, S, Chiarusi, T, Circella, M, Classen, L, Cocimano, R, Coelho, Jab, Coleiro, A, Colonges, S, Coniglione, R, Cordelli, M, Cosquer, A, Coyle, P, Creusot, A, Cuttone, G, D'Amico, A, De Bonis, G, De Rosa, G, De Sio, C, Di Capua, F, Di Palma, I, Garcia, Afd, Distefano, C, Donzaud, C, Dornic, D, Dorosti-Hasankiadeh, Q, Drakopoulou, E, Drouhin, D, Drury, L, Durocher, M, Eberl, T, Eichie, S, van Eijk, D, El Bojaddaini, I, El Khayati, N, Elsaesser, D, Enzenhofer, A, Fassi, F, Favali, P, Fermani, P, Ferrara, G, Filippidis, C, Frascadore, G, Fusco, La, Gal, T, Galata, S, Garufi, F, Gay, P, Gebyehu, M, Giordano, V, Gizani, N, Gracia, R, Graf, K, Gregoire, T, Grella, G, Habel, R, Hallmann, S, van Haren, H, Harissopulos, S, Heid, T, Heijboer, A, Heine, E, Henry, S, Hernandez-Rey, Jj, Hevinga, M, Hofestadt, J, Hugon, Cmf, Illuminati, G, James, Cw, Jansweijer, P, Jongen, M, de Jong, M, Kadler, M, Kalekin, O, Kappes, A, Katz, Uf, Keller, P, Kieft, G, Kiessling, D, Koffeman, En, Kooijman, P, Kouchner, A, Kulikovskiy, V, Lahmann, R, Lamare, P, Leisos, A, Leonora, E, Clark, Ml, Liolios, A, Alvarez, Cdl, Lo Presti, D, Lohner, H, Lonardo, A, Lotze, M, Loucatos, S, Maccioni, E, Mannheim, K, Margiotta, A, Marinelli, A, Maris, O, Markou, C, Martinez-Mora, Ja, Martini, A, Mele, R, Melis, Kw, Michael, T, Migliozzi, P, Migneco, E, Mijakowski, P, Miraglia, A, Mollo, Cm, Mongelli, M, Morganti, M, Moussa, A, Musico, P, Musumeci, M, Navas, S, Nicolau, Ca, Olcina, I, Olivetto, C, Orlando, A, Papaikonomou, A, Papaleo, R, Pavalas, Ge, Peek, H, Pellegrino, C, Perrina, C, Pfutzner, M, Piattelli, P, Pikounis, K, Poma, Ge, Popa, V, Pradier, T, Pratolongo, F, Puhlhofer, G, Pulvirenti, S, Quinn, L, Racca, C, Raffaelli, F, Randazzo, N, Rapidis, P, Razis, P, Real, D, Resvanis, L, Reubelt, J, Riccobene, G, Rossi, C, Rovelli, A, Saldana, M, Salvadori, I, Samtleben, Dfe, Garcia, A, Losa, A, Sanguineti, M, Santangelo, A, Santonocito, D, Sapienza, P, Schimmel, F, Schmelling, J, Sciacca, V, Sedita, M, Seitz, T, Sgura, I, Simeone, F, Siotis, I, Sipala, V, Spisso, B, Spurio, M, Stavropoulos, G, Steijger, J, Stellacci, Sm, Stransky, D, Taiuti, M, Tayalati, Y, Tezier, D, Theraube, S, Thompson, L, Timmer, P, Tonnis, C, Trasatti, L, Trovato, A, Tsirigotis, A, Tzamarias, S, Tzamariudaki, E, Vallage, B, Van Elewyck, V, Vermeulen, J, Vicini, P, Viola, S, Vivolo, D, Volkert, M, Voulgaris, G, Wiggers, L, Wilms, J, de Wolf, E, Zachariadou, K, Zornoza, Jd, and Zuniga, J

Subjects
HIGH-ENERGY NEUTRINOS, Physics - Instrumentation and Detectors, Computer science, Deep sea neutrino telescope, Física::Física de partícules [Àrees temàtiques de la UPC], Field of view, Electron, 7. Clean energy, 01 natural sciences, String (physics), KM3NeT, ARCA, ORCA, neutrino astronomy, neutrino astrophysics, neutrino mass hierarchy, High Energy Physics - Experiment, Relativistic particle, High Energy Physics - Experiment (hep-ex), [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], neutrino physics, deep sea neutrino telescope, High Energy Astrophysical Phenomena (astro-ph.HE), GAMMA-RAY BURSTS, OPT - Optics, TS - Technical Sciences, Industrial Innovation, [SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Astrophysics::Instrumentation and Methods for Astrophysics, Instrumentation and Detectors (physics.ins-det), Naturwissenschaftliche Fakultät, 16. Peace & justice, COSMIC-RAYS, Neutrino mass hierarchy, Neutrino physics, Neutrino astronomy, Nano Technology, Neutrino, Nuclear and High Energy Physics, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, SUPER-KAMIOKANDE, MONTE-CARLO GENERATOR, Astrophysics::High Energy Astrophysical Phenomena, Hochenergie-Astrophysik Theorie - Abteilung Hofmann, FOS: Physical sciences, PARAMETRIC-RESONANCE, 0103 physical sciences, ddc:530, Neutrins, 14. Life underwater, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Cherenkov radiation, Block (data storage), 010308 nuclear & particles physics, SIGNAL (programming language), neutrino physic, Astronomy, Galactic plane, Neutrino astrophysics, [SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], FISICA APLICADA, ddc:520, ICECUBE DATA, ATMOSPHERIC NEUTRINOS, GALACTIC-CENTER
Abstract

The authors would like to thank D Allard, A Esmaili, G Fogli, O Mena, K Murase, S Palomares Ruiz, E Parizot, S T Petcov, S Razzaque, D Semikoz, A Yu Smirnov, F L Villante, F Vissani and R Zukanovich Funchal for their support and valuable discussions and suggestions in preparing this Letter of Intent., The main objectives of the KM3NeT Collaboration are (i) the discovery and subsequent observation of high-energy neutrino sources in the Universe and (ii) the determination of the mass hierarchy of neutrinos. These objectives are strongly motivated by two recent important discoveries, namely: (1) the highenergy astrophysical neutrino signal reported by IceCube and (2) the sizable contribution of electron neutrinos to the third neutrino mass eigenstate as reported by Daya Bay, Reno and others. To meet these objectives, the KM3NeT Collaboration plans to build a new Research Infrastructure consisting of a network of deep-sea neutrino telescopes in the Mediterranean Sea. A phased and distributed implementation is pursued which maximises the access to regional funds, the availability of human resources and the synergistic opportunities for the Earth and sea sciences community. Three suitable deep-sea sites are selected, namely off-shore Toulon (France), Capo Passero (Sicily, Italy) and Pylos (Peloponnese, Greece). The infrastructure will consist of three so-called building blocks. A building block comprises 115 strings, each string comprises 18 optical modules and each optical module comprises 31 photo-multiplier tubes. Each building block thus constitutes a threedimensional array of photo sensors that can be used to detect the Cherenkov light produced by relativistic particles emerging from neutrino interactions. Two building blocks will be sparsely configured to fully explore the IceCube signal with similar instrumented volume, different methodology, improved resolution and complementary field of view, including the galactic plane. One building block will be densely configured to precisely measure atmospheric neutrino oscillations., The authors acknowledge the financial support of the funding agencies: Centre National de la Recherche Scientifique (CNRS), Commission Européenne (FEDER fund and Marie Curie Program), Institut Universitaire de France (IUF), IdEx program and UnivEarthS Labex program at Sorbonne Paris Cité (ANR-10-LABX-0023 and ANR-11-IDEX-0005-02), France; The General Secretariat of Research and Technology (GSRT), Greece; Istituto Nazionale di Fisica Nucleare (INFN), Ministero dell'Istruzione, dell’Universitàe della Ricerca (MIUR), Italy; Agence de l’Oriental and CNRST, Morocco; Stichting voor Fundamenteel Onderzoek der Materie (FOM), Nederlandseorganisatie voor Wetenschappelijk Onderzoek (NWO), The Netherlands; National Authority for Scientific Research (ANCS), Romania; Plan Estatal de Investigación (refs. FPA2015-65150-C3-1-P, -2-P and -3-P, (MINECO/FEDER)), Severo Ochoa Centre of Excellence and MultiDark Consolider (MINECO), and Prometeo and Grisolía programs (Generalitat Valenciana), Spain. The KM3NeT collaboration has received funding from the European Community Sixth Framework Programme under Contract 011937 and the Seventh Framework Programme under Grant Agreement 212525.

Published
2016

47. Expression of the immediate-early gene egr-1 and substance P in the spinal cord following locomotor training in adult rats

Author

Nunes, Ana Carla L., Duarte, Renata B., Sousa, Twyla B., dos Santos, José Ronaldo, Freire, Marco Aurélio M., and Costa, Miriam Stela Maris O.

Subjects
*GENE expression, *SUBSTANCE P, *SPINAL cord, *NEUROPLASTICITY, *LOCOMOTOR control, *LABORATORY rats, *NOCICEPTORS
Abstract

Abstract: The immediate-early gene egr-1 has been shown to have an increased expression during long-term potentiation (LTP). High frequency electrical stimulation induces an increase in such expression in the dorsal horn of the spinal cord. However, evidence demonstrating the activation of this gene in the spinal cord and its relationship with LTP is still scarce. The substance P (SP) has also been associated with LTP in the dorsal horn of the spinal cord following high frequency stimulation. Here we evaluated the expression of both Egr-1 and SP in the sacrolumbar area of the spinal cord after locomotor training in adult rats. Increased neuronal Egr-1 expression was found in the spinal cord sections in rats that underwent locomotor training, especially in laminae IV and X across L3–S4 levels (p <0.05). Conversely, SP expression in synaptic terminals was not altered in the abovementioned regions. Our results suggest that locomotor training activates mechanisms in a similar way to LTP, and is involved in the synaptic plasticity in the spinal cord. The results also indicate that variations in the training protocol influence Egr-1 expression. Such events appear not to be directly influenced by SP, which suggests a plastic process that differs from those triggered by nociceptive stimuli. [Copyright &y& Elsevier]

Published
2010
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48. A method to stabilise the performance of negatively fed KM3NeT photomultipliers

Author

M. Circella, C. D'Amato, Andrea Biagioni, G. Kieft, G. Pellegrini, Antonio Capone, S. Adrián-Martínez, P. Timmer, J. Schmelling, Piero Vicini, Maurizio Spurio, Rosanna Cocimano, Antonio D'Onofrio, A.J. Heijboer, J.A. Martínez-Mora, Fabrizio Ameli, G. Pühlhofer, M. de Jong, F. Terrasi, F. Versari, Bruny Baret, M. Ageron, M. Morganti, D. Lo Presti, Jörn Wilms, Els Koffeman, Michel André, C. Perrina, F. Di Capua, S. Eichie, P. Coyle, Giacomo Cuttone, B. Bouhadef, Paolo Fermani, Jürgen Brunner, E. Barbarito, Raffaele Buompane, V. Giordano, Mario Musumeci, A. Cosquer, R. Bruijn, G.E. Păvălaş, G. Ferrara, D. Stransky, A. Trovato, P. Migliozzi, A.M. van den Berg, V. Van Elewyck, A. Martini, A. Liolios, L. Quinn, I. Di Palma, G. C. Barbarino, Apostolos Tsirigotis, M. Durocher, Silvio Cherubini, I. Olcina, G. Cacopardo, Cristiano Bozza, T. Avgitas, M. M. Pfützner, N. Randazzo, E. Drakopoulou, Fabio Marzaioli, Herbert Löhner, S. Galatà, S. Bourret, S. Henry, G. E. Poma, K. Pikounis, M. Saldaña, Francesco Simeone, Alessandro Lonardo, F. Raffaelli, B. Vallage, A. Marinelli, M. Sedita, A. Sánchez Losa, L. Caillat, A. Enzenhöfer, Oleg Kalekin, Fabio Pratolongo, A. D'Amico, Antonios Leisos, C. Boutonnet, M. Gebyehu, Lucio Gialanella, J.D. Zornoza, Yahya Tayalati, D. Kießling, M.C. Bouwhuis, Sara Pulvirenti, Carmelo Pellegrino, F. Garufi, M. Volkert, R. Mele, Silvia Celli, Simona Maria Stellacci, S. Loucatos, T. Pradier, A. Coleiro, L. Classen, R. Bormuth, Vitaliano Chiarella, P. Piattelli, V. van Beveren, Matthias Kadler, L. K. Resvanis, V. Sciacca, M. Anghinolfi, Giulia Illuminati, D. van Eijk, S. Theraube, J. C. Vermeulen, K. Zachariadou, Domenico Santonocito, C. W. James, Patrick Lamare, Sotirios Harissopulos, H. van Haren, E. Migneco, L Chiarelli, F. Schimmel, G. Frascadore, B. Spisso, M. Cordelli, C. D. Llorens Alvarez, Valeria Sipala, T. Michael, Thomas Eberl, M. Lotze, M. Taiuti, A. Rovelli, Abdelilah Moussa, Paolo Musico, Michael Kreter, Carlos Maximiliano Mollo, L. Trasatti, F. Giacomini, M. Ardid, M. Furini, C. Olivetto, L.W. Wiggers, M. Hevinga, Nicolo' Beverini, H. Peek, C. Hugon, S. Colonges, D. Calvo, P. Jansweijer, Gisela Anton, S.F. Biagi, M. Billault, C. De Sio, A. Albert, E. Buis, C. Tönnis, Diego Real, C. Racca, Antoine Kouchner, Corinne Donzaud, Paolo Sapienza, P.M. Kooijman, A. Paolucci, A. Papaikonomou, E. Berbee, V. Popa, G. De Bonis, I. Salvadori, Robert Lahmann, J. Reubelt, T. Heid, Georgios Stavropoulos, Sebastiano Aiello, A. Sánchez García, Karl Mannheim, E. Tzamariudaki, M. Mongelli, I. El Bojaddaini, C. Rossi, M. Calamai, D. Drouhin, Q. Dorosti-Hasankiadeh, Steffen Hallmann, M. Bondì, E. G. Anassontzis, Damien Dornic, Jos Steijger, Riccardo Travaglini, Alexander Kappes, A. Miraglia, Salvatore Viola, E. Heine, Dominik Elsaesser, G. Bourlis, P. Keller, G. Grella, Matteo Sanguineti, G. Pancaldi, Andrea Santangelo, A. Grmek, P. Mijakowski, Kay Graf, Karel Melis, J. Barrios-Martí, Enrico Maccioni, R. Habel, M. Favaro, S. Beurthey, Nectaria A. B. Gizani, Carlo Alessandro Nicolau, M. Lindsey Clark, S. Tzamarias, C. Markou, Riccardo Papaleo, G. Riccobene, Uli Katz, A. Belias, A. Creusot, A. Orzelli, E. De Wolff, R. Gracia, G. Androulakis, Jutta Schnabel, O. Mariş, M. Jongen, Jose Busto, D. Cobas, J. Zúñiga, T. Gal, T. Seitz, C. Distefano, D. F. E. Samtleben, Daniele Vivolo, A. Margotti, S Zani, Luigi Antonio Fusco, Joao A B Coelho, M. Guerzoni, L. Caramete, T. Grégoire, Annarita Margiotta, D. Tézier, I. Sgura, Angelo Orlando, C. Champion, V. Kulikovskiy, M. Manzali, S. Cecchini, Juan José Hernández-Rey, Emanuele Leonora, Tommaso Chiarusi, R. Coniglione, J. Hofestädt, V. Bertin, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Km3NeT Collaboration, Adrián Martínez, S. Am, Ageron, M. B, Aiello, S. S, Albert, A. An, Ameli, F. W, Anassontzis, E. G. Ad, Andre, M. Al, Androulakis, G. Ab, Anghinolfi, M. T, Anton, G. G, Ardid, M. Am, Avgitas, T. C, Barbarino, G. Uai, Barbarito, E. Q, Baret, B. C, Barrios Martí, J. K, Belias, A. Ab, Berbee, E. F, Van Den Berg, A. Y, Bertin, V. B, Beurthey, S. B, Van Beveren, V. F, Beverini, N. Vaj, Biagi, S. O, Biagioni, A. W, Billault, M. B, Bondì, M. S, Bormuth, R. Fz, Bouhadef, B. V, Bourlis, G. J, Bourret, S. C, Boutonnet, C. C, Bouwhuis, M. F, Bozza, C. At, Bruijn, R. Aq, Brunner, J. B, Buis, E. Ag, Buompane, R. Uae, Busto, J. B, Cacopardo, G. O, Caillat, L. B, Calamai, M. V, Calvo, D. K, Capone, A. Wak, Caramete, L. X, Cecchini, S. R, Celli, S. Iwak, Champion, C. C, Cherubini, S. Oar, Chiarella, V. P, Chiarelli, L. Nr, Chiarusi, T. R, Circella, M. Q, Classen, L. G, Cobas, D. C, Cocimano, R. O, Coelho, J. A. B. C, Coleiro, A. C, Colonges, S. C, Coniglione, R. O, Cordelli, M. P, Cosquer, A. B, Coyle, P. B, Creusot, A. C, Cuttone, G. O, D'Amato, C. O, D'Amico, A. F, D'Onofrio, A. Uae, De Bonis, G. W, De Sio, C. At, DI CAPUA, Francesco, Di Palma, I. Wak, Distefano, C. O, Donzaud, C. C, Dornic, D. B, Dorosti Hasankiadeh, Q. Y, Drakopoulou, E. Ab, Drouhin, D. An, Durocher, M. Io, Eberl, T. G, Eichie, S. Gh, Van Eijk, D. F, El Bojaddaini, I. Ao, Elsaesser, D. Au, Enzenhöfer, A. B, Favaro, M. Nr, Fermani, P. W, Ferrara, G. Oar, Frascadore, G. O, Furini, M. R, Fusco, L. A. Rah, Gal, T. G, Galatà, S. C, Garufi, F. Uai, Gay, P. Cm, Gebyehu, M. F, Giacomini, F. Nr, Gialanella, L. Uae, Giordano, V. S, Gizani, N. J, Gracia, R. C, Graf, K. G, Grégoire, T. C, Grella, G. At, Grmek, A. O, Guerzoni, M. R, Habel, R. P, Hallmann, S. G, Van Haren, H. Ac, Harissopulos, S. Ab, Heid, T. G, Heijboer, A. F, Heine, E. F, Henry, S. B, Hernández Rey, J. J. K, Hevinga, M. Y, Hofestädt, J. G, Hugon, C. M. F. T, Illuminati, G. K, James, C. W. G, Jansweijer, P. F, Jongen, M. F, De Jong, M. F, Kadler, M. Au, Kalekin, O. G, Kappes, A. G, Katz, U. F. G, Keller, P. B, Kieft, G. F, Kießling, D. G, Koffeman, E. N. F, Kooijman, P. Aqav, Kouchner, A. C, Kreter, M. Au, Kulikovskiy, V. B, Lahmann, R. G, Lamare, P. B, Leisos, A. J, Leonora, E. S, Clark, M. L. C, Liolios, A. D, Alvarez, C. D. L. Am, Lo Presti, D. S, Löhner, H. Y, Lonardo, A. W, Lotze, M. K, Loucatos, S. C, Maccioni, E. Vaj, Mannheim, K. Au, Manzali, M. Nr, Margiotta, A. Rah, Margotti, A. R, Marinelli, A. Vaj, Mariš, O. X, Markou, C. Ab, Martínez Mora, J. A. Am, Martini, A. P, Marzaioli, F. Uae, Mele, R. Uai, Melis, K. W. F, Michael, T. F, Migliozzi, P. U, Migneco, E. O, Mijakowski, P. Aa, Miraglia, A. O, Mollo, C. M. U, Mongelli, M. Q, Morganti, M. Av, Moussa, A. Ao, Musico, P. T, Musumeci, M. O, Nicolau, C. A. W, Olcina, I. K, Olivetto, C. C, Orlando, A. O, Orzelli, A. T, Pancaldi, G. R, Paolucci, A. R, Papaikonomou, A. J, Papaleo, R. O, Pǎvǎlaš, G. E. X, Peek, H. F, Pellegrini, G. R, Pellegrino, C. Rah, Perrina, C. Wak, Pfutzner, M. F, Piattelli, P. O, Pikounis, K. Ab, Poma, G. E. Oar, Popa, V. X, Pradier, T. L, Pratolongo, F. T, Pühlhofer, G. E, Pulvirenti, S. O, Quinn, L. B, Racca, C. An, Raffaelli, F. V, Randazzo, N. S, Real, D. K, Resvanis, L. Ad, Reubelt, J. G, Riccobene, G. O, Rossi, C. T, Rovelli, A. O, Saldaña, M. Am, Salvadori, I. B, Samtleben, D. F. E. Fz, Sánchez García, A. K, Sánchez Losa, A. Q, Sanguineti, M. T, Santangelo, A. E, Santonocito, D. O, Sapienza, P. O, Schimmel, F. F, Schmelling, J. F, Schnabel, J. G, Sciacca, V. O, Sedita, M. O, Seitz, T. G, Sgura, I. Q, Simeone, F. W, Sipala, V. S, Spisso, B. Uat, Spurio, M. Rah, Stavropoulos, G. Ab, Steijger, J. F, Stellacci, S. M. At, Stransky, D. G, Taiuti, M. Ta, Tayalati, Y. Aoap, Terrasi, F. Uae, Tézier, D. B, Theraube, S. B, Timmer, P. F, Tönnis, C. K, Trasatti, L. P, Travaglini, R. R, Trovato, A. O, Tsirigotis, A. J, Tzamarias, S. D, Tzamariudaki, E. Ab, Vallage, B. C, Van Elewyck, V. C, Vermeulen, J. F, Versari, F. Rah, Vicini, P. W, Viola, S. O, Vivolo, D. Uai, Volkert, M. G, Wiggers, L. F, Wilms, J. H, De Wolf, E. Faq, Zachariadou, K. Af, Zani, S. Nr, Zornoza, J. D. K, Zúñiga, J. K., Adrián-Martínez, S., Ageron, M., Aiello, S., Albert, A., Ameli, F., Anassontzis, E.G., Andre, M., Androulakis, G., Anghinolfi, M., Anton, G., Ardid, M., Avgitas, T., Barbarino, G., Barbarito, E., Baret, B., Barrios-Martí, J., Belias, A., Berbee, E., Van Den Berg, A., Bertin, V., Beurthey, S., Van Beveren, V., Beverini, N., Biagi, S., Biagioni, A., Billault, M., Bondì, M., Bormuth, R., Bouhadef, B., Bourlis, G., Bourret, S., Boutonnet, C., Bouwhuis, M., Bozza, C., Bruijn, R., Brunner, J., Buis, E., Buompane, R., Busto, J., Cacopardo, G., Caillat, L., Calamai, M., Calvo, D., Capone, A., Caramete, L., Cecchini, S., Celli, S., Champion, C., Cherubini, S., Chiarella, V., Chiarelli, L., Chiarusi, T., Circella, M., Classen, L., Cobas, D., Cocimano, R., Coelho, J.A.B., Coleiro, A., Colonges, S., Coniglione, R., Cordelli, M., Cosquer, A., Coyle, P., Creusot, A., Cuttone, G., D'Amato, C., D'Amico, A., D'Onofrio, A., De Bonis, G., De Sio, C., Di Capua, F., Di Palma, I., Distefano, C., Donzaud, C., Dornic, D., Dorosti-Hasankiadeh, Q., Drakopoulou, E., Drouhin, D., Durocher, M., Eberl, T., Eichie, S., Van Eijk, D., El Bojaddaini, I., Elsaesser, D., Enzenhöfer, A., Favaro, M., Fermani, P., Ferrara, G., Frascadore, G., Furini, M., Fusco, L.A., Gal, T., Galatà, S., Garufi, F., Gay, P., Gebyehu, M., Giacomini, F., Gialanella, L., Giordano, V., Gizani, N., Gracia, R., Graf, K., Grégoire, T., Grella, G., Grmek, A., Guerzoni, M., Habel, R., Hallmann, S., Van Haren, H., Harissopulos, S., Heid, T., Heijboer, A., Heine, E., Henry, S., Hernández-Rey, J.J., Hevinga, M., Hofestädt, J., Hugon, C.M.F., Illuminati, G., James, C.W., Jansweijer, P., Jongen, M., De Jong, M., Kadler, M., Kalekin, O., Kappes, A., Katz, U.F., Keller, P., Kieft, G., Kießling, D., Koffeman, E.N., Kooijman, P., Kouchner, A., Kreter, M., Kulikovskiy, V., Lahmann, R., Lamare, P., Leisos, A., Leonora, E., Clark, M. Lindsey, Liolios, A., Alvarez, C.D. Lloren, Lo Presti, D., Löhner, H., Lonardo, A., Lotze, M., Loucatos, S., Maccioni, E., Mannheim, K., Manzali, M., Margiotta, A., Margotti, A., Marinelli, A., Mariš, O., Markou, C., Martínez-Mora, J.A., Martini, A., Marzaioli, F., Mele, R., Melis, K.W., Michael, T., Migliozzi, P., Migneco, E., Mijakowski, P., Miraglia, A., Mollo, C.M., Mongelli, M., Morganti, M., Moussa, A., Musico, P., Musumeci, M., Nicolau, C.A., Olcina, I., Olivetto, C., Orlando, A., Orzelli, A., Pancaldi, G., Paolucci, A., Papaikonomou, A., Papaleo, R., Pǎvǎlaš, G.E., Peek, H., Pellegrini, G., Pellegrino, C., Perrina, C., Pfutzner, M., Piattelli, P., Pikounis, K., Poma, G.E., Popa, V., Pradier, T., Pratolongo, F., Pühlhofer, G., Pulvirenti, S., Quinn, L., Racca, C., Raffaelli, F., Randazzo, N., Real, D., Resvanis, L., Reubelt, J., Riccobene, G., Rossi, C., Rovelli, A., Saldaña, M., Salvadori, I., Samtleben, D.F.E., Sánchez García, A., Sánchez Losa, A., Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schimmel, F., Schmelling, J., Schnabel, J., Sciacca, V., Sedita, M., Seitz, T., Sgura, I., Simeone, F., Sipala, V., Spisso, B., Spurio, M., Stavropoulos, G., Steijger, J., Stellacci, S.M., Stransky, D., Taiuti, M., Tayalati, Y., Terrasi, F., Tézier, D., Theraube, S., Timmer, P., Tönnis, C., Trasatti, L., Travaglini, R., Trovato, A., Tsirigotis, A., Tzamarias, S., Tzamariudaki, E., Vallage, B., Van Elewyck, V., Vermeulen, J., Versari, F., Vicini, P., Viola, S., Vivolo, D., Volkert, M., Wiggers, L., Wilms, J., De Wolf, E., Zachariadou, K., Zani, S., Zornoza, J.D., Zúñiga, J., Adrian-Martinez, S, Ageron, M, Aiello, S, Albert, A, Ameli, F, Anassontzis, Eg, Andre, M, Androulakis, G, Anghinolfi, M, Anton, G, Ardid, M, Avgitas, T, Barbarino, G, Barbarito, E, Baret, B, Barrios-Marti, J, Belias, A, Berbee, E, van den Berg, A, Bertin, V, Beurthey, S, van Beveren, V, Beverini, N, Biagi, S, Biagioni, A, Billault, M, Bondi, M, Bormuth, R, Bouhadef, B, Bourlis, G, Bourret, S, Boutonnet, C, Bouwhuis, M, Bozza, C, Bruijn, R, Brunner, J, Buis, E, Buompane, R, Busto, J, Cacopardo, G, Caillat, L, Calamai, M, Calvo, D, Capone, A, Caramete, L, Cecchini, S, Celli, S, Champion, C, Cherubini, S, Chiarella, V, Chiarelli, L, Chiarusi, T, Circella, M, Classen, L, Cobas, D, Cocimano, R, Coelho, Jab, Coleiro, A, Colonges, S, Coniglione, R, Cordelli, M, Cosquer, A, Coyle, P, Creusot, A, Cuttone, G, D'Amato, C, D'Amico, A, D'Onofrio, A, De Bonis, G, De Sio, C, Di Capua, F, Di Palma, I, Distefano, C, Donzaud, C, Dornic, D, Dorosti-Hasankiadeh, Q, Drakopoulou, E, Drouhin, D, Durocher, M, Eberl, T, Eichie, S, van Eijk, D, El Bojaddaini, I, Elsaesser, D, Enzenhofer, A, Favaro, M, Fermani, P, Ferrara, G, Frascadore, G, Furini, M, Fusco, La, Gal, T, Galata, S, Garufi, F, Gay, P, Gebyehu, M, Giacomini, F, Gialanella, L, Giordano, V, Gizani, N, Gracia, R, Graf, K, Gregoire, T, Grella, G, Grmek, A, Guerzoni, M, Habel, R, Hallmann, S, van Haren, H, Harissopulos, S, Heid, T, Heijboer, A, Heine, E, Henry, S, Hernandez-Rey, Jj, Hevinga, M, Hofestadt, J, Hugon, Cmf, Illuminati, G, James, Cw, Jansweijer, P, Jongen, M, de Jong, M, Kadler, M, Kalekin, O, Kappes, A, Katz, Uf, Keller, P, Kieft, G, Kiessling, D, Koffeman, En, Kooijman, P, Kouchner, A, Kreter, M, Kulikovskiy, V, Lahmann, R, Lamare, P, Leisos, A, Leonora, Je, Clark, Ml, Liolios, A, Alvarez, Cdl, Lo Presti, D, Lohner, H, Lonardo, A, Lotze, M, Loucatos, S, Maccioni, E, Mannheim, K, Manzali, M, Margiotta, A, Margotti, A, Marinelli, A, Maris, O, Markou, C, Martinez-Mora, Ja, Martini, A, Marzaioli, F, Mele, R, Melis, Kw, Michael, T, Migliozzi, P, Migneco, E, Mijakowski, P, Miraglia, A, Mollo, Cm, Mongelli, M, Morganti, M, Moussa, A, Musico, P, Musumeci, M, Nicolau, Ca, Olcina, I, Olivetto, C, Orlando, A, Orzelli, A, Pancaldi, G, Paolucci, A, Papaikonomou, A, Papaleo, R, Pavalas, Ge, Peek, H, Pellegrini, G, Pellegrino, C, Perrina, C, Pfutzner, M, Piattelli, P, Pikounis, K, Poma, Ge, Popa, V, Pradier, T, Pratolongo, F, Puhlhofer, G, Pulvirenti, S, Quinn, L, Racca, C, Raffaelli, F, Randazzo, N, Real, D, Resvanis, L, Reubelt, J, Riccobene, G, Rossi, C, Rovelli, A, Saldana, M, Salvadori, I, Samtleben, Dfe, Garcia, A, Losa, A, Sanguineti, M, Santangelo, A, Santonocito, D, Sapienza, P, Schimmel, F, Schmelling, J, Schnabel, J, Sciacca, V, Sedita, M, Seitz, T, Sgura, I, Simeone, F, Sipala, V, Spisso, B, Spurio, M, Stavropoulos, G, Steijger, J, Stellacci, Sm, Stransky, D, Taiuti, M, Tayalati, Y, Terrasi, F, Tezier, D, Theraube, S, Timmer, P, Tonnis, C, Trasatti, L, Travaglini, R, Trovato, A, Tsirigotis, A, Tzamarias, S, Tzamariudaki, E, Vallage, B, Van Elewyck, V, Vermeulen, J, Versari, F, Vicini, P, Viola, S, Vivolo, D, Volkert, M, Wiggers, L, Wilms, J, de Wolf, E, Zachariadou, K, Zani, S, Zornoza, Jd, Zuniga, J, Centre Tecnològic de Vilanova i la Geltrú, Universitat Politècnica de Catalunya. LAB - Laboratori d'Aplicacions Bioacústiques, Research unit Astroparticle Physics, Adrián Martínez, S., Anassontzis, E. G., Barrios Martí, J., Coelho, J. A. B., D'Onofrio, Antonio, Dorosti Hasankiadeh, Q., Fusco, L. A., Gialanella, Lucio, Hernández Rey, J. J., Hugon, C. M. F., James, C. W., Katz, U. F., Koffeman, E. N., Alvarez, C. D. Lloren, Martínez Mora, J. A., Marzaioli, Fabio, Melis, K. W., Mollo, C. M., Nicolau, C. A., Pǎvǎlaš, G. E., Poma, G. E., Samtleben, D. F. E., Stellacci, S. M., Terrasi, Filippo, and Zornoza, J. D.

Subjects
PROTOTYPE, Physics::Instrumentation and Detectors, photomultiplier, coating, KM3NeT, neutrino telescope, Instrument optimization, Large detector systems for particle and astroparticle physics, Neutrino detectors, Photon detectors for UV, visible and IR photons (gas) (gas-photocathodes, solid-photocathodes), Instrumentation, Mathematical Physics, 01 natural sciences, Neutrino detector, 010303 astronomy & astrophysics, Photon detectors for UV, Physics, OPT - Optics, TS - Technical Sciences, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], Instrument optimisation, Astrophysics::Instrumentation and Methods for Astrophysics, High voltage, Optoelectronics, Nano Technology, Neutrino, Photomultiplier, visible and IR photons (gas) (gas-photocathodes, Context (language use), Photon detectors for UV, visible and IR photons (gas) (gas-photocathodes, solid-photocathode, Partícules (Física nuclear), Photocathode, NO, Optics, 0103 physical sciences, Neutrins, 14. Life underwater, Electronics, Neutrinos, Detectors òptics, Optical detectors, Física [Àrees temàtiques de la UPC], 010308 nuclear & particles physics, business.industry, Neutrino astrophysics, [SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], FISICA APLICADA, Large detector systems for particle and astroparticle physic, Visible and IR photons (gas) (gas-photocathodes, solid-photocathodes), solid-photocathodes), business
Abstract

[EN] The KM3NeT research infrastructure, currently under construction in the Mediterranean Sea, will host neutrino telescopes for the identification of neutrino sources in the Universe and for studies of the neutrino mass hierarchy. These telescopes will house hundreds of thousands of photomultiplier tubes that will have to be operated in a stable and reliable fashion. In this context, the stability of the dark counts has been investigated for photomultiplier tubes with negative high voltage on the photocathode and held in insulating support structures made of 3D printed nylon material. Small gaps between the rigid support structure and the photomultiplier tubes in the presence of electric fields can lead to discharges that produce dark count rates that are highly variable. A solution was found by applying the same insulating varnish as used for the high voltage bases directly to the outside of the photomultiplier tubes. This transparent conformal coating provides a convenient and inexpensive method of insulation., The authors acknowledge the financial support of the funding agencies: Centre National de la Recherche Scientifique (CNRS), Commission Europeenne (FEDER fund and Marie Curie Program), Institut Universitaire de France (IUF), IdEx program and UnivEarthS Labex program at Sorbonne Paris Cite (ANR-10-LABX-0023 and ANR-11-IDEX-0005-02), France; The General Secretariat of Research and Technology (GSRT), Greece; Istituto Nazionale di Fisica Nucleare (INFN), Ministero dell'Istruzione, dell'Universita e della Ricerca (MIUR), Italy; Agence de l'Oriental and CNRST, Morocco; Stichting voor Fundamenteel Onderzoek der Materie (FOM), Nederlandse organisatie voorWetenschappelijk Onderzoek (NWO), the Netherlands; National Authority for Scientific Research (ANCS), Romania; Plan Estatal de Investigacion (refs. FPA2015-65150-C3-1-P, -2-P and -3-P, (MINECO/FEDER)), Severo Ochoa Centre of Excellence and MultiDark Consolider (MINECO), and Prometeo and Grisolia programs (Generalitat Valenciana), Spain.

Published
2016

49. The prototype detection unit of the KM3NeT detector: KM3NeT Collaboration

Author

S. Adrián-Martínez, M. Ageron, F. Aharonian, S. Aiello, A. Albert, F. Ameli, E. G. Anassontzis, G. C. Androulakis, M. Anghinolfi, G. Anton, S. Anvar, M. Ardid, T. Avgitas, K. Balasi, H. Band, G. Barbarino, E. Barbarito, F. Barbato, B. Baret, S. Baron, J. Barrios, A. Belias, E. Berbee, A. M. van den Berg, A. Berkien, V. Bertin, S. Beurthey, V. van Beveren, N. Beverini, S. Biagi, A. Biagioni, S. Bianucci, M. Billault, A. Birbas, H. Boer Rookhuizen, R. Bormuth, V. Bouché, B. Bouhadef, G. Bourlis, C. Boutonnet, M. Bouwhuis, C. Bozza, R. Bruijn, J. Brunner, G. Cacopardo, L. Caillat, M. Calamai, D. Calvo, A. Capone, L. Caramete, F. Caruso, S. Cecchini, A. Ceres, R. Cereseto, C. Champion, F. Château, T. Chiarusi, B. Christopoulou, M. Circella, L. Classen, R. Cocimano, A. Coleiro, S. Colonges, R. Coniglione, A. Cosquer, M. Costa, P. Coyle, A. Creusot, G. Cuttone, C. D’Amato, A. D’Amico, G. De Bonis, G. De Rosa, N. Deniskina, J.-J. Destelle, C. Distefano, F. Di Capua, C. Donzaud, D. Dornic, Q. Dorosti-Hasankiadeh, E. Drakopoulou, D. Drouhin, L. Drury, D. Durand, T. Eberl, D. Elsaesser, A. Enzenhöfer, P. Fermani, L. A. Fusco, D. Gajanana, T. Gal, S. Galatà, F. Garufi, M. Gebyehu, V. Giordano, N. Gizani, R. Gracia Ruiz, K. Graf, R. Grasso, G. Grella, A. Grmek, R. Habel, H. van Haren, T. Heid, A. Heijboer, E. Heine, S. Henry, J. J. Hernández-Rey, B. Herold, M. A. Hevinga, M. van der Hoek, J. Hofestädt, J. Hogenbirk, C. Hugon, J. Hößl, M. Imbesi, C. W. James, P. Jansweijer, J. Jochum, M. de Jong, M. Jongen, M. Kadler, O. Kalekin, A. Kappes, E. Kappos, U. Katz, O. Kavatsyuk, P. Keller, G. Kieft, E. Koffeman, H. Kok, P. Kooijman, J. Koopstra, A. Korporaal, A. Kouchner, I. Kreykenbohm, V. Kulikovskiy, R. Lahmann, P. Lamare, G. Larosa, D. Lattuada, H. Le Provost, K. P. Leismüller, A. Leisos, D. Lenis, E. Leonora, M. Lindsey Clark, C. D. Llorens Alvarez, H. Löhner, A. Lonardo, S. Loucatos, F. Louis, E. Maccioni, K. Mannheim, K. Manolopoulos, A. Margiotta, O. Mariş, C. Markou, J. A. Martínez-Mora, A. Martini, R. Masullo, K. W. Melis, T. Michael, P. Migliozzi, E. Migneco, A. Miraglia, C. M. Mollo, M. Mongelli, M. Morganti, S. Mos, Y. Moudden, P. Musico, M. Musumeci, C. Nicolaou, C. A. Nicolau, A. Orlando, A. Orzelli, A. Papaikonomou, R. Papaleo, G. E. Păvălaş, H. Peek, C. Pellegrino, M. G. Pellegriti, C. Perrina, P. Piattelli, K. Pikounis, V. Popa, Th. Pradier, M. Priede, G. Pühlhofer, S. Pulvirenti, C. Racca, F. Raffaelli, N. Randazzo, P. A. Rapidis, P. Razis, D. Real, L. Resvanis, J. Reubelt, G. Riccobene, A. Rovelli, M. Saldaña, D. F. E. Samtleben, M. Sanguineti, A. Santangelo, P. Sapienza, J. Schmelling, J. Schnabel, V. Sciacca, M. Sedita, T. Seitz, I. Sgura, F. Simeone, V. Sipala, A. Spitaleri, M. Spurio, G. Stavropoulos, J. Steijger, T. Stolarczyk, D. Stransky, M. Taiuti, G. Terreni, D. Tézier, S. Théraube, L. F. Thompson, P. Timmer, L. Trasatti, A. Trovato, M. Tselengidou, A. Tsirigotis, S. Tzamarias, E. Tzamariudaki, B. Vallage, V. Van Elewyck, J. Vermeulen, P. Vernin, P. Vicini, S. Viola, D. Vivolo, P. Werneke, L. Wiggers, J. Wilms, E. de Wolf, R. H. L. van Wooning, E. Zonca, J. D. Zornoza, J. Zúñiga, A. Zwart, Adrian-Martinez, S., Ageron, M., Aharonian, F., Aiello, S., Albert, A., Ameli, F., Anassontzis, E. G., Androulakis, G. C., Anghinolfi, M., Anton, G., Anvar, S., Ardid, M., Avgitas, T., Balasi, K., Band, H., Barbarino, G., Barbarito, E., Barbato, F., Baret, B., Baron, S., Barrios, J., Belias, A., Berbee, E., van den Berg, A. M., Berkien, A., Bertin, V., Beurthey, S., van Beveren, V., Beverini, N., Biagi, S., Biagioni, A., Bianucci, S., Billault, M., Birbas, A., Boer Rookhuizen, H., Bormuth, R., Bouche, V., Bouhadef, B., Bourlis, G., Boutonnet, C., Bouwhuis, M., Bozza, C., Bruijn, R., Brunner, J., Cacopardo, G., Caillat, L., Calamai, M., Calvo, D., Capone, A., Caramete, L., Caruso, F., Cecchini, S., Ceres, A., Cereseto, R., Champion, C., Chateau, F., Chiarusi, T., Christopoulou, B., Circella, M., Classen, L., Cocimano, R., Coleiro, A., Colonges, S., Coniglione, R., Cosquer, A., Costa, M., Coyle, P., Creusot, A., Cuttone, G., D'Amato, C., D'Amico, A., De Bonis, G., De Rosa, G., Deniskina, N., Destelle, J. -J., Distefano, C., Di Capua, F., Donzaud, C., Dornic, D., Dorosti-Hasankiadeh, Q., Drakopoulou, E., Drouhin, D., Drury, L., Durand, D., Eberl, T., Elsaesser, D., Enzenhofer, A., Fermani, P., Fusco, L. A., Gajanana, D., Gal, T., Galata, S., Garufi, F., Gebyehu, M., Giordano, V., Gizani, N., Gracia Ruiz, R., Graf, K., Grasso, R., Grella, G., Grmek, A., Habel, R., van Haren, H., Heid, T., Heijboer, A., Heine, E., Henry, S., Hernandez-Rey, J. J., Herold, B., Hevinga, M. A., van der Hoek, M., Hofestadt, J., Hogenbirk, J., Hugon, C., Hossl, J., Imbesi, M., James, C. W., Jansweijer, P., Jochum, J., de Jong, M., Jongen, M., Kadler, M., Kalekin, O., Kappes, A., Kappos, E., Katz, U., Kavatsyuk, O., Keller, P., Kieft, G., Koffeman, E., Kok, H., Kooijman, P., Koopstra, J., Korporaal, A., Kouchner, A., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Lamare, P., Larosa, G., Lattuada, D., Le Provost, H., Leismuller, K. P., Leisos, A., Lenis, D., Leonora, E., Lindsey Clark, M., Llorens Alvarez, C. D., Lohner, H., Lonardo, A., Loucatos, S., Louis, F., Maccioni, E., Mannheim, K., Manolopoulos, K., Margiotta, A., Maris, O., Markou, C., Martinez-Mora, J. A., Martini, A., Masullo, R., Melis, K. W., Michael, T., Migliozzi, P., Migneco, E., Miraglia, A., Mollo, C. M., Mongelli, M., Morganti, M., Mos, S., Moudden, Y., Musico, P., Musumeci, M., Nicolaou, C., Nicolau, C. A., Orlando, A., Orzelli, A., Papaikonomou, A., Papaleo, R., Pavalas, G. E., Peek, H., Pellegrino, C., Pellegriti, M. G., Perrina, C., Piattelli, P., Pikounis, K., Popa, V., Pradier, T., Priede, M., Puhlhofer, G., Pulvirenti, S., Racca, C., Raffaelli, F., Randazzo, N., Rapidis, P. A., Razis, P., Real, D., Resvanis, L., Reubelt, J., Riccobene, G., Rovelli, A., Saldana, M., Samtleben, D. F. E., Sanguineti, M., Santangelo, A., Sapienza, P., Schmelling, J., Schnabel, J., Sciacca, V., Sedita, M., Seitz, T., Sgura, I., Simeone, F., Sipala, V., Spitaleri, A., Spurio, M., Stavropoulos, G., Steijger, J., Stolarczyk, T., Stransky, D., Taiuti, M., Terreni, G., Tezier, D., Theraube, S., Thompson, L. F., Timmer, P., Trasatti, L., Trovato, A., Tselengidou, M., Tsirigotis, A., Tzamarias, S., Tzamariudaki, E., Vallage, B., Van Elewyck, V., Vermeulen, J., Vernin, P., Vicini, P., Viola, S., Vivolo, D., Werneke, P., Wiggers, L., Wilms, J., de Wolf, E., van Wooning, R. H. L., Zonca, E., Zornoza, J. D., Zuniga, J., Zwart, A., Adrián Martínez, S., Biagi, S, Bouché, V., Château, F., D’Amato, C., D’Amico, A., Destelle, J. J., Dorosti Hasankiadeh, Q., Enzenhöfer, A., Fusco, LUIGI ANTONIO, Galatà, S., Hernández Rey, J. J., Hofestädt, J., Hößl, J., Leismüller, K. P., Löhner, H., Margiotta, Annarita, Mariş, O., Martínez Mora, J. A., Păvălaş, G. E., Pellegrino, Carmelo, Pradier, T. h., Pühlhofer, G., Saldaña, M., Spurio, Maurizio, Tézier, D., Théraube, S., and Zúñiga, J.

Subjects
Physics, Photomultiplier, Physics and Astronomy (miscellaneous), Physics::Instrumentation and Detectors, 010308 nuclear & particles physics, business.industry, Detector, Monte Carlo method, 01 natural sciences, Signal, Optics, KM3NeT, 0103 physical sciences, Calibration, 14. Life underwater, Neutrino, 010306 general physics, business, Engineering (miscellaneous), Cherenkov radiation
Abstract

A prototype detection unit of the KM3NeT deep-sea neutrino telescope has been installed at 3500m depth 80 km offshore the Italian coast. KM3NeT in its final configuration will contain several hundreds of detection units. Each detection unit is a mechanical structure anchored to the sea floor, held vertical by a submerged buoy and supporting optical modules for the detection of Cherenkov light emitted by charged secondary particles emerging from neutrino interactions. This prototype string implements three optical modules with 31 photomultiplier tubes each. These optical modules were developed by the KM3NeT Collaboration to enhance the detection capability of neutrino interactions. The prototype detection unit was operated since its deployment in May 2014 until its decommissioning in July 2015. Reconstruction of the particle trajectories from the data requires a nanosecond accuracy in the time calibration. A procedure for relative time calibration of the photomultiplier tubes contained in each optical module is described. This procedure is based on the measured coincidences produced in the sea by the $$^{40}$$40K background light and can easily be expanded to a detector with several thousands of optical modules. The time offsets between the different optical modules are obtained using LED nanobeacons mounted inside them. A set of data corresponding to 600 h of livetime was analysed. The results show good agreement with Monte Carlo simulations of the expected optical background and the signal from atmospheric muons. An almost background-free sample of muons was selected by filtering the time correlated signals on all the three optical modules. The zenith angle of the selected muons was reconstructed with a precision of about 3$$^circ $$∘.

Published
2016

50. Deep sea tests of a prototype of the KM3NeT digital optical module: KM3NeT Collaboration

Author

Adrián-Martínez, S., Ageron, M., Aharonian, F., Aiello, S., Albert, A., Ameli, F., Anassontzis, E. G., Anghinolfi, M., Anton, G., Anvar, S., Ardid, M., de Asmundis, R., Balasi, K., Band, H., Barbarino, G., Barbarito, E., Barbato, F., Baret, B., Baron, S., Belias, A., Berbee, E., van den Berg, A. M., Berkien, A., Bertin, V., Beurthey, S., van Beveren, V., Beverini, N., Biagi, S., Bianucci, S., Billault, M., Birbas, A., Boer Rookhuizen, H., Bormuth, R., Bouché, V., Bouhadef, B., Bourlis, G., Bouwhuis, M., Bozza, C., Bruijn, R., Brunner, J., Cacopardo, G., Caillat, L., Calamai, M., Calvo, D., Capone, A., Caramete, L., Caruso, F., Cecchini, S., Ceres, A., Cereseto, R., Champion, C., Château, F., Chiarusi, T., Christopoulou, B., Circella, M., Classen, L., Cocimano, R., Colonges, S., Coniglione, R., Cosquer, A., Costa, M., Coyle, P., Creusot, A., Curtil, C., Cuttone, G., D’Amato, C., D’Amico, A., De Bonis, G., De Rosa, G., Deniskina, N., Destelle, J. J., Distefano, C., Donzaud, C., Dornic, D., Dorosti-Hasankiadeh, Q., Drakopoulou, E., Drouhin, D., Drury, L., Durand, D., Eberl, T., Eleftheriadis, C., Elsaesser, D., Enzenhöfer, A., Fermani, P., Fusco, L. A., Gajana, D., Gal, T., Galatà, S., Gallo, F., Garufi, F., Gebyehu, M., Giordano, V., Gizani, N., Gracia Ruiz, R., Graf, K., Grasso, R., Grella, G., Grmek, A., Habel, R., van Haren, H., Heid, T., Heijboer, A., Heine, E., Henry, S., Hernández-Rey, J. J., Herold, B., Hevinga, M. A., van der Hoek, M., Hofestädt, J., Hogenbirk, J., Hugon, C., Hößl, J., Imbesi, M., James, C., Jansweijer, P., Jochum, J., de Jong, M., Kadler, M., Kalekin, O., Kappes, A., Kappos, E., Katz, U., Kavatsyuk, O., Keller, P., Kieft, G., Koffeman, E., Kok, H., Kooijman, P., Koopstra, J., Korporaal, A., Kouchner, A., Koutsoukos, S., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Lamare, P., Larosa, G., Lattuada, D., Le Provost, H., Leisos, A., Lenis, D., Leonora, E., Lindsey Clark, M., Liolios, A., Llorens Alvarez, C. D., Löhner, H., Lo Presti, D., Louis, F., Maccioni, E., Mannheim, K., Manolopoulos, K., Margiotta, A., Mariş, O., Markou, C., Martínez-Mora, J. A., Martini, A., Masullo, R., Michael, T., Migliozzi, P., Migneco, E., Miraglia, A., Mollo, C., Mongelli, M., Morganti, M., Mos, S., Moudden, Y., Musico, P., Musumeci, M., Nicolaou, C., Nicolau, C. A., Orlando, A., Orzelli, A., Papageorgiou, K., Papaikonomou, A., Papaleo, R., Păvălaş, G. E., Peek, H., Pellegrino, C., Pellegriti, M. G., Perrina, C., Petridou, C., Piattelli, P., Pikounis, K., Popa, V., Pradier, Th, Priede, M., Pühlhofer, G., Pulvirenti, S., Racca, C., Raffaelli, F., Randazzo, N., Rapidis, P. A., Razis, P., Real, D., Resvanis, L., Reubelt, J., Riccobene, G., Rovelli, A., Royon, J., Saldaña, M., Samtleben, D. F E, Sanguineti, M., Santangelo, A., Sapienza, P., Savvidis, I., Schmelling, J., Schnabel, J., Sedita, M., Seitz, T., Sgura, I., Simeone, F., Siotis, I., Sipala, V., Solazzo, M., Spitaleri, A., Spurio, M., Stavropoulos, G., Steijger, J., Stolarczyk, T., Stransky, D., Taiuti, M., Terreni, G., Tézier, D., Théraube, S., Thompson, L. F., Timmer, P., Trapierakis, H. I., Trasatti, L., Trovato, A., Tselengidou, M., Tsirigotis, A., Tzamarias, S., Tzamariudaki, E., Vallage, B., Van Elewyck, V., Vermeulen, J., Vernin, P., Viola, S., Vivolo, D., Werneke, P., Wiggers, L., Wilms, J., de Wolf, E., van Wooning, R. H L, Yatkin, K., Zachariadou, K., Zonca, E., Zornoza, J. D., Zúñiga, J., Zwart, A., Sub Subatomic Physics (SAP), Subatomic Physics Institute, Sub Subatomic Physics (SAP), Subatomic Physics Institute, Adrian-Martinez, S., Ageron, M., Aharonian, F., Aiello, S., Albert, A., Ameli, F., Anassontzis, E. G., Anghinolfi, M., Anton, G., Anvar, S., Ardid, M., de Asmundis, R., Balasi, K., Band, H., Barbarino, G., Barbarito, E., Barbato, F., Baret, B., Baron, S., Belias, A., Berbee, E., van den Berg, A. M., Berkien, A., Bertin, V., Beurthey, S., van Beveren, V., Beverini, N., Biagi, S., Bianucci, S., Billault, M., Birbas, A., Boer Rookhuizen, H., Bormuth, R., Bouche, V., Bouhadef, B., Bourlis, G., Bouwhuis, M., Bozza, C., Bruijn, R., Brunner, J., Cacopardo, G., Caillat, L., Calamai, M., Calvo, D., Capone, A., Caramete, L., Caruso, F., Cecchini, S., Ceres, A., Cereseto, R., Champion, C., Chateau, F., Chiarusi, T., Christopoulou, B., Circella, M., Classen, L., Cocimano, R., Colonges, S., Coniglione, R., Cosquer, A., Costa, M., Coyle, P., Creusot, A., Curtil, C., Cuttone, G., D'Amato, C., D'Amico, A., De Bonis, G., De Rosa, G., Deniskina, N., Destelle, J. -J., Distefano, C., Donzaud, C., Dornic, D., Dorosti-Hasankiadeh, Q., Drakopoulou, E., Drouhin, D., Drury, L., Durand, D., Eberl, T., Eleftheriadis, C., Elsaesser, D., Enzenhofer, A., Fermani, P., Fusco, L. A., Gajana, D., Gal, T., Galata, S., Gallo, F., Garufi, F., Gebyehu, M., Giordano, V., Gizani, N., Gracia Ruiz, R., Graf, K., Grasso, R., Grella, G., Grmek, A., Habel, R., van Haren, H., Heid, T., Heijboer, A., Heine, E., Henry, S., Hernandez-Rey, J. J., Herold, B., Hevinga, M. A., van der Hoek, M., Hofestadt, J., Hogenbirk, J., Hugon, C., Hossl, J., Imbesi, M., James, C., Jansweijer, P., Jochum, J., de Jong, M., Kadler, M., Kalekin, O., Kappes, A., Kappos, E., Katz, U., Kavatsyuk, O., Keller, P., Kieft, G., Koffeman, E., Kok, H., Kooijman, P., Koopstra, J., Korporaal, A., Kouchner, A., Koutsoukos, S., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Lamare, P., Larosa, G., Lattuada, D., Le Provost, H., Leisos, A., Lenis, D., Leonora, E., Lindsey Clark, M., Liolios, A., Llorens Alvarez, C. D., Lohner, H., Lo Presti, D., Louis, F., Maccioni, E., Mannheim, K., Manolopoulos, K., Margiotta, A., Maris, O., Markou, C., Martinez-Mora, J. A., Martini, A., Masullo, R., Michael, T., Migliozzi, P., Migneco, E., Miraglia, A., Mollo, C., Mongelli, M., Morganti, M., Mos, S., Moudden, Y., Musico, P., Musumeci, M., Nicolaou, C., Nicolau, C. A., Orlando, A., Orzelli, A., Papageorgiou, K., Papaikonomou, A., Papaleo, R., Pavalas, G. E., Peek, H., Pellegrino, C., Pellegriti, M. G., Perrina, C., Petridou, C., Piattelli, P., Pikounis, K., Popa, V., Pradier, T., Priede, M., Puhlhofer, G., Pulvirenti, S., Racca, C., Raffaelli, F., Randazzo, N., Rapidis, P. A., Razis, P., Real, D., Resvanis, L., Reubelt, J., Riccobene, G., Rovelli, A., Royon, J., Saldana, M., Samtleben, D. F. E., Sanguineti, M., Santangelo, A., Sapienza, P., Savvidis, I., Schmelling, J., Schnabel, J., Sedita, M., Seitz, T., Sgura, I., Simeone, F., Siotis, I., Sipala, V., Solazzo, M., Spitaleri, A., Spurio, M., Stavropoulos, G., Steijger, J., Stolarczyk, T., Stransky, D., Taiuti, M., Terreni, G., Tezier, D., Theraube, S., Thompson, L. F., Timmer, P., Trapierakis, H. I., Trasatti, L., Trovato, A., Tselengidou, M., Tsirigotis, A., Tzamarias, S., Tzamariudaki, E., Vallage, B., Van Elewyck, V., Vermeulen, J., Vernin, P., Viola, S., Vivolo, D., Werneke, P., Wiggers, L., Wilms, J., de Wolf, E., van Wooning, R. H. L., Yatkin, K., Zachariadou, K., Zonca, E., Zornoza, J. D., Zuniga, J., and Zwart, A.

Subjects
Physics, Photomultiplier, Photon, Physics and Astronomy (miscellaneous), 010308 nuclear & particles physics, business.industry, Physics::Instrumentation and Detectors, Detector, Astrophysics::Instrumentation and Methods for Astrophysics, 01 natural sciences, Signal, Photocathode, Optics, KM3NeT, 0103 physical sciences, 14. Life underwater, Sensitivity (control systems), 010306 general physics, business, Engineering (miscellaneous), Cherenkov radiation
Abstract

The first prototype of a photo-detection unit of the future KM3NeT neutrino telescope has been deployed in the deep waters of the Mediterranean Sea. This digital optical module has a novel design with a very large photocathode area segmented by the use of 31 three inch photomultiplier tubes. It has been integrated in the ANTARES detector for in-situ testing and validation. This paper reports on the first months of data taking and rate measurements. The analysis results highlight the capabilities of the new module design in terms of background suppression and signal recognition. The directionality of the optical module enables the recognition of multiple Cherenkov photons from the same $^{40}$K decay and the localization bioluminescent activity in the neighbourhood. The single unit can cleanly identify atmospheric muons and provide sensitivity to the muon arrival directions.

Published
2014

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