1. Gut microbiome and atrial fibrillation—results from a large population-based study
- Author
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Palmu, Joonatan, Börschel, Christin S, Ortega-Alonso, Alfredo, Markó, Lajos, Inouye, Michael, Jousilahti, Pekka, Salido, Rodolfo A, Sanders, Karenina, Brennan, Caitriona, Humphrey, Gregory C, Sanders, Jon G, Gutmann, Friederike, Linz, Dominik, Salomaa, Veikko, Havulinna, Aki S, Forslund, Sofia K, Knight, Rob, Lahti, Leo, Niiranen, Teemu, and Schnabel, Renate B
- Subjects
Epidemiology ,Biomedical and Clinical Sciences ,Clinical Sciences ,Health Sciences ,Cardiovascular ,Heart Disease ,Prevention ,Genetics ,2.1 Biological and endogenous factors ,Aetiology ,Humans ,Atrial Fibrillation ,Gastrointestinal Microbiome ,Heart ,Bacteria ,Aging ,Incidence ,Atrial fibrillation ,Gut microbiome ,Metagenomics ,Public Health and Health Services ,Clinical sciences - Abstract
BackgroundAtrial fibrillation (AF) is an important heart rhythm disorder in aging populations. The gut microbiome composition has been previously related to cardiovascular disease risk factors. Whether the gut microbial profile is also associated with the risk of AF remains unknown.MethodsWe examined the associations of prevalent and incident AF with gut microbiota in the FINRISK 2002 study, a random population sample of 6763 individuals. We replicated our findings in an independent case-control cohort of 138 individuals in Hamburg, Germany.FindingsMultivariable-adjusted regression models revealed that prevalent AF (N = 116) was associated with nine microbial genera. Incident AF (N = 539) over a median follow-up of 15 years was associated with eight microbial genera with false discovery rate (FDR)-corrected P
- Published
- 2023