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Background We assessed the correlation of posterior corneal asphericity and the refractive prediction error of the SRK-T and Barrett II Universal formulas for eyes following phacovitrectomy with peeling of the internal limiting membrane (ILM). Patients and Methods We retrospectively analyzed 41 eyes of 41 patients following a combined phacovitrectomy with ILM peeling. Surgeries were performed by one fellowship-trained vitreoretinal surgeon between 2016 and 2021. Results Of the 41 patients, 41 eyes were included, with all having at least 1 month of postoperative data. Of the 41 eyes, 19 eyes were female (46%) and 22 were male (54%). The average age of the study population was 77.5 ± 10.7 years. The mean axial length (AL) was 22.7 ± 4.6 mm and the mean anterior chamber depth (ACD) was 3 ± 0.8 mm. The mean posterior Q value was − 0.29 ± 0.27. The mean absolute error (MAE) values 1-month postoperatively for the SRK-T and Barrett II Universal formulas were 0.73 and 0.65, respectively. Regression analysis yielded a significant correlation between posterior corneal asphericity and SRK-T MAE (r = 0.35, R2 = 0.12, p Conclusions Posterior corneal surface asphericity is correlated to the refractive error of the SRK-T formula for eyes following phacovitrectomy.

To evaluate the influence of posterior corneal asphericity on the refractive error using SRK-T and Barrett formulas for the intraocular lens (IOL) power calculation for Lucidis Extended Depth of Focus (EDOF) IOL.This study was carried out at a tertiary ophthalmology center in Geneva, Switzerland.A retrospective study. Medical records from all enrolled patients were analyzed and the following information was extracted retrospectively, over 1 month following surgery.We retrospectively reviewed 75 eyes that underwent cataract surgery and were implanted with a Lucidis EDOF IOL. We measured the posterior corneal asphericity (Q value), axial length (AL), and anterior chamber depth (ACD) and then calculated the IOL power using SRK-T and Barrett formulas.Seventy-five eyes were included, all of which had 1-month postoperative data. In the cohort, 32 eyes were from females (43%) and 43 from males (57%). The mean age of the study population was 73 ± 8.8 years. The mean AL was 23.5 ± 0.98 and the mean ACD was 3.13 ± 0.3. The mean posterior Q value was - 0.35 ± 0.2. In a regression analysis, we found a statistically significant relationship between the error in refraction prediction and the posterior Q value, irrespective of the formula used. The relationship between posterior corneal asphericity and the refraction prediction error was stronger for the Barrett II Universal formula than for the SRK-T formula.Posterior corneal asphericity was correlated with the refractive error of calculation of both SRK-T and Barrett formulas, with a stronger correlation to the latter formula.ZIEL: Den Einfluss der posterioren Hornhautasphärizität auf den refraktiven Fehler der mit SRK‑T- und Barrett-Formeln kalkulierten Intraokularlinsenberechnungen (IOL-Berechnungen) für Lucidis-Extended-Depth-of-Focus-Intraokularlinsen (EDOF: Extended Depth of Focus) zu evaluieren. ORT: Diese Studie wurde in einem Tertiärzentrum für Augenheilkunde in Genf, Schweiz, durchgeführt.Eine retrospektive Studie. Die Gesundheitsakten aller in die Studie aufgenommenen Patienten wurden analysiert; die Daten für den 1. Monat nach der Operation wurden retrospektiv extrahiert.Es wurden 75 Augen nach Kataraktoperation mit Implantation einer Lucidis-EDOF-IOL retrospektiv überprüft. Wir haben die posteriore Hornhautasphärizität (Q-Wert), axiale Länge (AL) und Vorderkammertiefe (VKT) gemessen; die IOL-Berechnung wurde mit den SRK‑T- und Barrett-Formeln durchgeführt.Es wurden 75 Augen in die Studie aufgenommen. Für alle Augen lagen die postoperativen Daten für den 1. Monat nach der Operation vor. In dem Patientenkollektiv waren 32 Augen von Frauen (43%) und 43 von Männern (57%). Das Durchschnittsalter der Studienpopulation betrug 73 ± 8,8 Jahre. Die durchschnittliche AL betrug 23,5 ± 0,98 und die mittlere VKT betrug 3,13 ± 0,3. Der durchschnittliche Q-Wert der hinteren Hornhautfläche betrug − 0,35 ± 0,2. Bei der Regressionsanalyse fanden wir eine statistisch signifikante Beziehung zwischen dem refraktiven Vorhersagefehler und dem Q-Wert der hinteren Hornhautfläche, ungeachtet der für die Berechnung verwendeten Formel. Die Verbindung zwischen posteriorer Hornhautasphärizität und refraktivem Vorhersagefehler war mit der Barrett-Universal-II-Formel stärker als mit der SRK‑T-Formel.Die posteriore Hornhautasphärizität korrelierte sowohl mit dem mit der SRK‑T-Formel als auch mit dem mit der Barrett-Formel kalkulierten refraktiven Fehler, wobei die Korrelation mit der letztgenannten Formel stärker ausgeprägt war.

This review aimed to evaluate the incidence of posterior capsule opacification (PCO) after femtosecond laser-assisted cataract surgery (FLACS) during a 24-month follow-up period. The findings were compared with a control group comprising standard micro-incision cataract surgery (MICS) using two types of acrylic intraocular lens. This retrospective study was carried out at a tertiary ophthalmology center in Geneva, Switzerland. The medical records of all enrolled patients were analyzed and data from the 24-month follow-up period were extracted. We reviewed 100 eyes that underwent cataract surgery: 50 eyes underwent cataract surgery using the FLACS technique and 50 eyes were operated on with the MICS standard technique, the latter comprising the control group. The primary outcome measure was the formation of PCO. The secondary outcome was the rate of Nd:YAG capsulotomy and the change in best-corrected visual acuity (BCVA) after the Nd:YAG procedure. In both groups, the mean time of appearance of PCO requiring treatment by Nd:YAG was 451 and 480 days, respectively (p > 0.05). After Nd:YAG capsulotomy, the FLACS group had a BCVA change of 0.24 ± 0.18 compared with the MICS group that demonstrated a change of 0.27 ± 1.37 (p > 0.05). The odds ratio of the formation of PCO following treatment with Nd:YAG capsulotomy was 0.44 (95% CI: 0.19–0.98, p

To assess the impact of posterior corneal asphericity on postoperative calculation error using the Haigis-L and the Barrett formulas for eyes after laser in situ keratomileusis or photorefractive keratectomy (PRK).We assessed the mean absolute error (MAE) of two power calculation formulas, Barrett true-K and Haigis-L formulas, in a retrospective analysis of 34 eyes of 34 patients who underwent cataract surgery. We performed a regression analysis between corneal parameters (anterior and posterior Q values, Kmax, K1, and K2) and the MAE of each formula.In the cohort, 11 eyes were of women and 23 of men. The average age of the study population was 66.5±8.6 years. The mean axial length was 24±4.7 mm, the mean anterior chamber depth was 3.27±0.7 mm, and the mean posterior Q-value was -0.15±0.28. The MAE of Haigis-L and Barrett true-K formulas were 0.72 and 0.68, respectively (P=0.54). The regression analysis showed a statistically significant relationship only between the error in refraction prediction and the posterior Q-value regardless of the formula used. The coefficient of determination was higher for the Barrett true-K formula (r=0.52; R2=0.28; P0.05), compared with the Haigis-L (r=0.49; R2=0.25; P0.05).Posterior corneal surface asphericity influences the refractive error of calculation using both Haigis-L and Barrett true-K formulas for eyes after a myopic PRK or laser-assisted in situ keratomileusis surgery.

Aim. To assess the impact of posterior corneal asphericity on postoperative astigmatism. Methods. We included retrospectively 70 eyes of 70 patients that underwent cataract surgery. We included data of the Q value, Kmax, K1, K2, astigmatism AL, and ACD. We performed a vectorial analysis to calculate the astigmatic vectors. Results. Seventy eyes were evaluated. 40 eyes were of females (58%) and 30 of males (42%). The average cohort age was 73 ± 8.9 years. Axial length (AL) was 23.5 ± 0.9, anterior chamber depth (ACD) was 3.13 ± 0.3, and the average posterior Q value was −0.35 ± 0.2. The only significant predictive variable for the correction index (CI) was the posterior Q value (r = 0.24, p p

This study sought to compare the short-term outcome of uterine incision repair during a Caesarean section (CS) using a bidirectional knotless barbed suture versus polyglactin suture.A randomized controlled trial was conducted at a university hospital. Participants undergoing a CS were randomly assigned to uterine incision closure by bidirectional knotless barbed suture (group A) or polyglactin (group B). The primary outcome was the time needed to repair the uterine incision. The analysis was by intent to treat. A sample size of 35 per group (n = 70) was planned to detect a 30% reduction in uterine repair time (Canadian Task Force Classification I).From July 2016 through October 2017, 150 women were screened, and 70 were statistically analyzed: group A (n = 35) and group B (n = 35). Time to complete uterine incision repair was 308 ± 57 seconds for group A and 411 ± 74 seconds for group B (P 0.001). Total surgery time (33.4 ± 8.8 minutes vs. 33.2 ± 7.5 minutes; P = 0.64) was not significantly different between groups A and B, respectively.Repair of the CS uterine incision with barbed suture compared with polyglactin suture reduces suturing time.

OBJECTIVE To evaluate atrial and ventricular parameters using real time three-dimensional transthoracic echocardiography (RT3DTTE) in women treated with nifedipine in the early third trimester (III-T) of pregnancy. METHODS A prospective single-subject design study in a university-affiliated hospital, where each participant served as her own control. We studied 25 pregnant women at a gestational age of 25-33 weeks with TPTL prior to vs 48 hours postnifedipine treatment. Two-dimensional transthoracic echocardiography (2DTTE) and RT3DTTE were used to study 3D left atrial (LA) volumes and indexes, emptying fraction, left ventricular and LA cavities, and total vascular resistance (TVR). RESULTS Two-dimensional transthoracic echocardiography showed a significant increase in LA area (from 15.2 ± 2.62 to 16.16 ± 2.21 mm2 , P = .02) before vs after nifedipine; RT3DTTE showed a significant change in LA end-diastolic volume index (from 23.7 ± 4.2 to 26.75 ± 3.8 mL/m2 , P = .008). LA end-systolic volume and index were not significantly different before vs after nifedipine (from 24.56 ± 8 to 25.3 ± 5.5 mL, from 13.6 ± 5.3 to 14.8 ± 3.4 mL/m2 ); P > .05, respectively. E/a ratio, E-tdi, and E/E-tdi did not change significantly ([from 2.54 ± 4.46 to 2.54 ± 4.1], [from 11.9 ± 1.9 to 11.9 ± 2], [from 7.8 ± 1.4 to 7.6 ± 1.1], respectively, P > .05). Tricuspid annular plane systolic excursion (TAPSE) did not change significantly from 23.77 ± 4.2 to 23.9 ± 3.3, P = .1. There was a significant decrease in pulmonary pressure (from 25.4 ± 4.2 to 23 ± 2.5 mm Hg, P = .02), in mean arterial pressure (from 80 ± 4 to 76 ± 3 mm Hg, P

Background The ratio between the fetal umbilical artery pulsatility index (UA-PI) and the middle cerebral artery pulsatility index (MCA-PI) is termed the cerebroplacental ratio (CPR). The CPR represents fetal blood flow redistribution at the early stages of placental insufficiency; moreover, it has predictive value for adverse intrapartum and neonatal outcomes. However, internationally accepted reference ranges for CPR are lacking. Objective This study sought to establish UA-PI, MCA-PI, and CPR reference ranges in low-risk, normal-growth singleton fetuses during the third trimester of pregnancy. Methods A retrospective cohort cross-sectional study was performed in the obstetrics ultrasound unit of a university hospital in Israel. We reviewed all fetal and maternal electronic records of pregnant women referred for ultrasound assessment during the third trimester between January 2014 and January 2019. We included only singleton pregnancies with normal anatomy scans and a normal third-trimester estimated fetal weight. The UA-PI, MCA-PI, and CPR reference ranges were reconstructed for each of the vessels for each gestational age between 29 and 41 weeks. Results A total of 560 pregnancies met the inclusion criteria. Satisfactory waveforms and measurements were obtained in all cases. At least 18 women enrolled at each gestational week. The MCA-PI and CPR values showed a similar parabolic curve during the third trimester of pregnancy, with a peak value at 32 and 33 gestational weeks, respectively. The UA-PI showed a linear and gradual decrease over the gestational age. Conclusions In this study we established UA-PI, MCA-PI, and CPR reference ranges in low-risk, normal-growth singleton fetuses during the third trimester based on the Israeli population.

Objective: To evaluate the predictive value of local versus external cerebroplacental ratio (CPR) reference ranges for delivery outcomes in low-risk pregnancies. Methods: A retrospective analysis of all feto-maternal demographic and biometric data in fetuses with normal estimated fetal weight (EFW) and a CPR examination between the years 2014–2019, in a university medical center. The study group included healthy singleton pregnancies from 32-week gestation, with an examination-to-delivery interval of Results: Overall, 410 low-risk pregnancies with normal weight fetuses were enrolled in the study. All three CPR models turned out to be significant predictors of CD, with an odds ratio (OR) of 9, 95% CI (2.7–27), p p p p p p Conclusions: A CPR model based on local reference ranges and

Mid-trimester beta-human chorionic gonadotropin (BHCG) levels are considerably higher in pregnancies resulting from frozen embryo transfer (FET) compared with fresh (FRET), leading to a higher false positive rate in aneuploidy screening tests. We aimed to investigate the dynamics of BHCG increment and its predictive value for cycle outcome. A retrospective analysis of FRET and FET cycles. BHCG values on days 14 and 16 post embryo transfer were compared and stratified according to the number of sacs demonstrated on US scan at six weeks gestation, and pregnancy outcome (biochemical pregnancy, ectopic pregnancy, spontaneous abortion, and a singleton or twin birth). A prediction model for live birth was built. A total of 430 treatment cycles were analyzed. The average BHCG levels were significantly higher in FET compared with FRET group in nonviable pregnancies on day 14, 450 vs. 183 IU/L, p .05 and day 16, 348 vs. 735 IU/L, p .05, respectively. The increment of BHCG was significantly steeper in the FET compared with FRET group in biochemical pregnancies (F = 6.485, p = .012*). Optimal cutoff level for live birth prediction in the FRET group was 211 IU/L (sensitivity 84%, specificity 76.2%) for day 14 and 440 IU/L (sensitivity 86.0% and specificity 72.5%) for day 16. The increment in BHCG differed significantly between the FRET and FET cycles in nonviable pregnancies. Nevertheless, the difference in BHCG levels observed in the second trimester in pregnancies conceived after FRET and FET cycle may begin as early as the fourth week of pregnancy.

Objective: We aimed to review a single-center experience in follow-up and management of fetuses with umbilical vein varix (UVV) and to assess the effect of UVV on fetal Doppler parameters.Methods: ...

Background The ratio between the fetal umbilical artery pulsatility index (UA-PI) and the middle cerebral artery pulsatility index (MCA-PI) is termed the cerebroplacental ratio (CPR). The CPR represents fetal blood flow redistribution at the early stages of placental insufficiency; moreover, it has predictive value for adverse intrapartum and neonatal outcomes. However, internationally accepted reference ranges for CPR are lacking. Objective This study sought to establish UA-PI, MCA-PI, and CPR reference ranges in low-risk, normal-growth singleton fetuses during the third trimester of pregnancy. Methods A retrospective cohort cross-sectional study was performed in the obstetrics ultrasound unit of a university hospital in Israel. We reviewed all fetal and maternal electronic records of pregnant women referred for ultrasound assessment during the third trimester between January 2014 and January 2019. We included only singleton pregnancies with normal anatomy scans and a normal third-trimester estimated fetal weight. The UA-PI, MCA-PI, and CPR reference ranges were reconstructed for each of the vessels for each gestational age between 29 and 41 weeks. Results A total of 560 pregnancies met the inclusion criteria. Satisfactory waveforms and measurements were obtained in all cases. At least 18 women enrolled at each gestational week. The MCA-PI and CPR values showed a similar parabolic curve during the third trimester of pregnancy, with a peak value at 32 and 33 gestational weeks, respectively. The UA-PI showed a linear and gradual decrease over the gestational age. Conclusions In this study we established UA-PI, MCA-PI, and CPR reference ranges in low-risk, normal-growth singleton fetuses during the third trimester based on the Israeli population.