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1. Fludarabine-treosulfan versus fludarabine-melphalan or busulfan-cyclophosphamide conditioning in older AML or MDS patients – A clinical trial to registry data comparison

Author

Beelen, Dietrich Wilhelm, Iacobelli, Simona, Koster, Linda, Eikema, Dirk-Jan, van Biezen, Anja, Stölzel, Friedrich, Ciceri, Fabio, Bethge, Wolfgang, Dreger, Peter, Wagner-Drouet, Eva-Maria, Reményi, Péter, Stelljes, Matthias, Markiewicz, Miroslaw, McLornan, Donal P., Yakoub-Agha, Ibrahim, and Mohty, Mohamad

Published
2024
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3. Allogeneic Hematopoietic Stem Cell Transplantation for Paroxysmal Nocturnal Hemoglobinuria: Multicenter Analysis by the Polish Adult Leukemia Group

Author

Markiewicz, Miroslaw, Drozd-Sokolowska, Joanna, Biecek, Przemyslaw, Dzierzak-Mietla, Monika, Boguradzki, Piotr, Staniak, Mateusz, Piatkowska-Jakubas, Beata, Piekarska, Agnieszka, Tormanowska, Magdalena, Halaburda, Kazimierz, Ussowicz, Marek, Waszczuk-Gajda, Anna, Basak, Grzegorz, Bołkun, Lukasz, Rybka, Justyna, Sadus-Wojciechowska, Maria, Giebel, Sebastian, Szmigielska-Kaplon, Anna, Mendek-Czajkowska, Ewa, Warzybok, Katarzyna, Burdacki, Adrian, and Dwilewicz-Trojaczek, Jadwiga

Published
2020
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4. Treosulfan or busulfan plus fludarabine as conditioning treatment before allogeneic haemopoietic stem cell transplantation for older patients with acute myeloid leukaemia or myelodysplastic syndrome (MC-FludT.14/L): a randomised, non-inferiority, phase 3 trial

Author

Beelen, Dietrich Wilhelm, Trenschel, Rudolf, Stelljes, Matthias, Groth, Christoph, Masszi, Tamás, Reményi, Péter, Wagner-Drouet, Eva-Maria, Hauptrock, Beate, Dreger, Peter, Luft, Thomas, Bethge, Wolfgang, Vogel, Wichard, Ciceri, Fabio, Peccatori, Jacopo, Stölzel, Friedrich, Schetelig, Johannes, Junghanß, Christian, Grosse-Thie, Christina, Michallet, Mauricette, Labussiere-Wallet, Hélène, Schaefer-Eckart, Kerstin, Dressler, Sabine, Grigoleit, Goetz Ulrich, Mielke, Stephan, Scheid, Christof, Holtick, Udo, Patriarca, Francesca, Medeot, Marta, Rambaldi, Alessandro, Micò, Maria Caterina, Niederwieser, Dietger, Franke, Georg-Nikolaus, Hilgendorf, Inken, Winkelmann, Nils Rudolf, Russo, Domenico, Socié, Gérard, Peffault de Latour, Régis, Holler, Ernst, Wolff, Daniel, Glass, Bertram, Casper, Jochen, Wulf, Gerald, Menzel, Helge, Basara, Nadezda, Bieniaszewska, Maria, Stuhler, Gernot, Verbeek, Mareike, Grass, Sandra, Iori, Anna Paola, Finke, Juergen, Benedetti, Fabio, Pichlmeier, Uwe, Hemmelmann, Claudia, Tribanek, Michael, Klein, Anja, Mylius, Heidrun Anke, Baumgart, Joachim, Dzierzak-Mietla, Monika, and Markiewicz, Miroslaw

Published
2020
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5. Genetically determined telomere length and multiple myeloma risk and outcome

Author

Giaccherini, Matteo, Macauda, Angelica, Orciuolo, Enrico, Rymko, Marcin, Gruenpeter, Karolina, Dumontet, Charles, Raźny, Malgorzata, Moreno, Victor, Buda, Gabriele, Beider, Katia, Varkonyi, Judit, Avet-Loiseau, Hervé, Martinez-Lopez, Joaquín, Marques, Herlander, Watek, Marzena, Sarasquete, Maria Eugenia, Andersen, Vibeke, Karlin, Lionel, Suska, Anna, Kruszewski, Marcin, Abildgaard, Niels, Dudziński, Marek, Butrym, Aleksandra, Nagler, Arnold, Vangsted, Annette Juul, Kadar, Katalin, Waldemar, Tomczak, Jamroziak, Krzysztof, Jacobsen, Svend Erik Hove, Ebbesen, Lene Hyldahl, Taszner, Michał, Mazur, Grzegorz, Lesueur, Fabienne, Pelosini, Matteo, Garcia-Sanz, Ramon, Jurczyszyn, Artur, Demangel, Delphine, Reis, Rui Manuel, Iskierka-Jażdżewska, Elżbieta, Markiewicz, Miroslaw, Gemignani, Federica, Subocz, Edyta, Zawirska, Daria, Druzd-Sitek, Agnieszka, Stępień, Anna, Alonso, M. Henar, Sainz, Juan, Canzian, Federico, and Campa, Daniele

Published
2021
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6. HLA-inferred extended haplotype disparity level is more relevant than the level of HLA mismatch alone for the patients survival and GvHD in T cell-replate hematopoietic stem cell transplantation from unrelated donor

Author

Nowak, Jacek, Nestorowicz, Klaudia, Graczyk-Pol, Elzbieta, Mika-Witkowska, Renata, Rogatko-Koros, Marta, Jaskula, Emilia, Koscinska, Katarzyna, Madej, Sylwia, Tomaszewska, Agnieszka, Nasilowska-Adamska, Barbara, Szczepinski, Andrzej, Halaburda, Kazimierz, Dybko, Jaroslaw, Kuliczkowski, Kazimierz, Czerw, Tomasz, Giebel, Sebastian, Holowiecki, Jerzy, Baranska, Malgorzata, Pieczonka, Anna, Wachowiak, Jacek, Czyz, Anna, Gil, Lidia, Lojko-Dankowska, Anna, Komarnicki, Mieczyslaw, Bieniaszewska, Maria, Kucharska, Agnieszka, Hellmann, Andrzej, Gronkowska, Anna, Jedrzejczak, Wieslaw W., Markiewicz, Miroslaw, Koclega, Anna, Kyrcz-Krzemien, Slawomira, Mielcarek, Monika, Kalwak, Krzysztof, Styczynski, Jan, Wysocki, Mariusz, Drabko, Katarzyna, Wojcik, Beata, Kowalczyk, Jerzy, Gozdzik, Jolanta, Pawliczak, Daria, Gwozdowicz, Slawomir, Dziopa, Joanna, Szlendak, Urszula, Witkowska, Agnieszka, Zubala, Marta, Gawron, Agnieszka, Warzocha, Krzysztof, and Lange, Andrzej

Published
2018
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7. Analiza skuteczności ibrutynibu w podgrupie chorych na przewlekłą białaczkę limfocytową z delecją 17p: badanie obserwacyjne Polskiej Grupy ds. Leczenia Białaczek u Dorosłych (PALG)

Author

Puła, Bartosz, Iskierka-Jażdżewska, Elżbieta, Hus, Marek, Szymczyk, Agnieszka, Gołos, Aleksandra, Piotrowska, Magdalena, Zawirska, Daria, Zaucha, Jan Maciej, Steckiewicz, Paweł, Pasiarski, Marcin, Chraniuk, Dominik, Piszczek, Weronika, Osowiecki, Michał, Subocz, Edyta, Hałka, Janusz, Waszczuk-Gajda, Anna, Drozd-Sokołowska, Joanna, Knopińska-Posłuszny, Wanda, Dudziński, Marek, Hołojda, Jadwiga, Wojciechowska, Małgorzata, Kulikowski, Waldemar, Szeremet, Agnieszka, Kumiega, Beata, Pluta, Andrzej, Markiewicz, Mirosław, Giannopoulos, Krzysztof, Robak, Tadeusz, Warzocha, Krzysztof, and Jamroziak, Krzysztof

Published
2017
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8. Polymorphisms within Autophagy-Related Genes as Susceptibility Biomarkers for Multiple Myeloma: A Meta-Analysis of Three Large Cohorts and Functional Characterization

Author

Clavero, Esther, primary, Sanchez-Maldonado, José Manuel, additional, Macauda, Angelica, additional, Ter Horst, Rob, additional, Sampaio-Marques, Belém, additional, Jurczyszyn, Artur, additional, Clay-Gilmour, Alyssa, additional, Stein, Angelika, additional, Hildebrandt, Michelle A. T., additional, Weinhold, Niels, additional, Buda, Gabriele, additional, García-Sanz, Ramón, additional, Tomczak, Waldemar, additional, Vogel, Ulla, additional, Jerez, Andrés, additional, Zawirska, Daria, additional, Wątek, Marzena, additional, Hofmann, Jonathan N., additional, Landi, Stefano, additional, Spinelli, John J., additional, Butrym, Aleksandra, additional, Kumar, Abhishek, additional, Martínez-López, Joaquín, additional, Galimberti, Sara, additional, Sarasquete, María Eugenia, additional, Subocz, Edyta, additional, Iskierka-Jażdżewska, Elzbieta, additional, Giles, Graham G., additional, Rybicka-Ramos, Malwina, additional, Kruszewski, Marcin, additional, Abildgaard, Niels, additional, Verdejo, Francisco García, additional, Sánchez Rovira, Pedro, additional, da Silva Filho, Miguel Inacio, additional, Kadar, Katalin, additional, Razny, Małgorzata, additional, Cozen, Wendy, additional, Pelosini, Matteo, additional, Jurado, Manuel, additional, Bhatti, Parveen, additional, Dudzinski, Marek, additional, Druzd-Sitek, Agnieszka, additional, Orciuolo, Enrico, additional, Li, Yang, additional, Norman, Aaron D., additional, Zaucha, Jan Maciej, additional, Reis, Rui Manuel, additional, Markiewicz, Miroslaw, additional, Rodríguez Sevilla, Juan José, additional, Andersen, Vibeke, additional, Jamroziak, Krzysztof, additional, Hemminki, Kari, additional, Berndt, Sonja I., additional, Rajkumar, Vicent, additional, Mazur, Grzegorz, additional, Kumar, Shaji K., additional, Ludovico, Paula, additional, Nagler, Arnon, additional, Chanock, Stephen J., additional, Dumontet, Charles, additional, Machiela, Mitchell J., additional, Varkonyi, Judit, additional, Camp, Nicola J., additional, Ziv, Elad, additional, Vangsted, Annette Juul, additional, Brown, Elizabeth E., additional, Campa, Daniele, additional, Vachon, Celine M., additional, Netea, Mihai G., additional, Canzian, Federico, additional, Försti, Asta, additional, and Sainz, Juan, additional

Published
2023
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9. Treosulfan compared with <scp>reduced‐intensity</scp> busulfan improves allogeneic hematopoietic cell transplantation outcomes of older acute myeloid leukemia and myelodysplastic syndrome patients: Final analysis of a prospective randomized trial

Author

Beelen, Dietrich, Stelljes, Matthias, Reményi, Péter, Wagner‐Drouet, Eva‐Maria, Dreger, Peter, Bethge, Wolfgang, Ciceri, Fabio, Stölzel, Friedrich, Junghanß, Christian, Labussiere‐Wallet, Hélène, Schaefer‐Eckart, Kerstin, Grigoleit, Goetz U., Scheid, Christof, Patriarca, Francesca, Rambaldi, Alessandro, Niederwieser, Dietger, Hilgendorf, Inken, Russo, Domenico, Socié, Gérard, Holler, Ernst, Glass, Bertram, Casper, Jochen, Wulf, Gerald, Basara, Nadezda, Bieniaszewska, Maria, Stuhler, Gernot, Verbeek, Mareike, La Rocca, Ursula, Finke, Jürgen, Benedetti, Fabio, Pichlmeier, Uwe, Klein, Anja, Baumgart, Joachim, Markiewicz, Miroslaw, and Rocca, Ursula La

Subjects
Leukemia, Myeloid, Acute, Transplantation Conditioning, Myelodysplastic Syndromes, Medizin, Hematopoietic Stem Cell Transplantation, Graft vs Host Disease, Humans, Prospective Studies, Hematology, Middle Aged, Busulfan, Vidarabine, Aged
Abstract

The phase III study was designed to compare event-free survival (EFS) after treosulfan-based conditioning with a widely applied reduced-intensity conditioning (RIC) busulfan regimen in older or comorbid patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) undergoing allogeneic hematopoietic cell transplantation (HCT). A previously reported confirmatory interim analysis of the randomized clinical study including 476 patients demonstrated statistically significant noninferiority for treosulfan with clinically meaningful improvement in EFS. Here, the final study results and pre-specified subgroup analyses of all 570 randomized patients with completed longer-term follow-up are presented. Patients presenting HCT-specific comorbidity index >2 or aged >= 50 years were randomly assigned (1:1) to intravenous (IV) fludarabine with either treosulfan (30 g/m(2) IV) or busulfan (6.4 mg/kg IV) after stratification by disease risk group, donor type, and participating institution. The primary endpoint was EFS with disease recurrence, graft failure, or death from any cause as events. EFS of patients (median age 60 years) was superior after treosulfan compared to RIC busulfan: 36-months-EFS rate 59.5% (95% CI, 52.2-66.1) vs. 49.7% (95% CI, 43.3-55.7) with a hazard ratio (HR) of 0.64 (95% CI, 0.49-0.84), p = 0.0006. Likewise, overall survival (OS) with treosulfan was superior compared to busulfan: 36-month-OS rate 66.8% vs. 56.3%; HR 0.64 (95% CI, 0.48-0.87), p = 0.0037. Post hoc analyses revealed that these differences were consistent with the confirmatory interim analysis, and thereby the treosulfan regimen appears particularly suitable for older AML and MDS patients.

Published
2022

11. Role of Donor Activating KIR–HLA Ligand–Mediated NK Cell Education Status in Control of Malignancy in Hematopoietic Cell Transplant Recipients

Author

Nowak, Jacek, Kościńska, Katarzyna, Mika-Witkowska, Renata, Rogatko-Koroś, Marta, Mizia, Sylwia, Jaskuła, Emilia, Polak, Małgorzata, Mordak-Domagała, Monika, Lange, Janusz, Gronkowska, Anna, Jędrzejczak, Wiesław Wiktor, Kyrcz-Krzemień, Sławomira, Markiewicz, Mirosław, Dzierżak-Mietła, Monika, Tomaszewska, Agnieszka, Nasiłowska-Adamska, Barbara, Szczepiński, Andrzej, Hałaburda, Kazimierz, Hellmann, Andrzej, Czyż, Anna, Gil, Lidia, Komarnicki, Mieczysław, Wachowiak, Jacek, Barańska, Małgorzata, Kowalczyk, Jerzy, Drabko, Katarzyna, Goździk, Jolanta, Wysoczańska, Barbara, Bogunia-Kubik, Katarzyna, Graczyk-Pol, Elżbieta, Witkowska, Agnieszka, Marosz-Rudnicka, Anna, Nestorowicz, Klaudia, Dziopa, Joanna, Szlendak, Urszula, Warzocha, Krzysztof, and Lange, Andrzej

Published
2015
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13. NOD2/CARD15 Single Nucleotide Polymorphism 13 (3020insC) is Associated with Risk of Sepsis and Single Nucleotide Polymorphism 8 (2104C>T) with Herpes Viruses Reactivation in Patients after Allogeneic Hematopoietic Stem Cell Transplantation

Author

Jaskula, Emilia, Lange, Andrzej, Kyrcz-Krzemien, Slawomira, Markiewicz, Miroslaw, Dzierzak-Mietla, Monika, Jedrzejczak, Wieslaw Wiktor, Czajka, Przemyslaw, Mordak-Domagala, Monika, Lange, Janusz, Gronkowska, Anna, Nowak, Jacek, Warzocha, Krzysztof, Hellmann, Andrzej, Kowalczyk, Jerzy, Drabko, Katarzyna, Gozdzik, Jolanta, and Mizia, Sylwia

Published
2014
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14. Treosulfan compared with reduced‐intensity busulfan improves allogeneic hematopoietic cell transplantation outcomes of older acute myeloid leukemia and myelodysplastic syndrome patients: Final analysis of a prospective randomized trial

Author

Beelen, Dietrich W., primary, Stelljes, Matthias, additional, Reményi, Péter, additional, Wagner‐Drouet, Eva‐Maria, additional, Dreger, Peter, additional, Bethge, Wolfgang, additional, Ciceri, Fabio, additional, Stölzel, Friedrich, additional, Junghanß, Christian, additional, Labussiere‐Wallet, Hélène, additional, Schaefer‐Eckart, Kerstin, additional, Grigoleit, Goetz U., additional, Scheid, Christof, additional, Patriarca, Francesca, additional, Rambaldi, Alessandro, additional, Niederwieser, Dietger, additional, Hilgendorf, Inken, additional, Russo, Domenico, additional, Socié, Gérard, additional, Holler, Ernst, additional, Glass, Bertram, additional, Casper, Jochen, additional, Wulf, Gerald, additional, Basara, Nadezda, additional, Bieniaszewska, Maria, additional, Stuhler, Gernot, additional, Verbeek, Mareike, additional, La Rocca, Ursula, additional, Finke, Jürgen, additional, Benedetti, Fabio, additional, Pichlmeier, Uwe, additional, Klein, Anja, additional, Baumgart, Joachim, additional, and Markiewicz, Miroslaw, additional

Published
2022
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15. Multicenter Analyses Demonstrate Significant Clinical Effects of Minor Histocompatibility Antigens on GvHD and GvL after HLA-Matched Related and Unrelated Hematopoietic Stem Cell Transplantation

Author

Spierings, Eric, Kim, Yeung-Hyen, Hendriks, Matthijs, Borst, Eric, Sergeant, Ruhena, Canossi, Angelica, Oudshoorn, Machteld, Loiseau, Pascale, Dolstra, Harry, Markiewicz, Miroslaw, Leffell, Mary S., Pereira, Noemi, Kircher, Brigitte, Turpeinen, Hannu, Eliaou, Jean-François, Gervais, Thibaut, Laurin, David, Enczmann, Jürgen, Martinetti, Miryam, Thomson, Jackie, Oguz, Fatma, Santarone, Stella, Partanen, Jukka, Siekiera, Urszula, Alessandrino, Emilio Paolo, Kalayoglu, Sevgi, Brand, Ronald, and Goulmy, Els

Published
2013
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19. Favourable Outcome after Treosulfan Based Conditioning of Patients Receiving an Allogeneic Hematopoietic Cell Transplantation (AlloHCT) for the Treatment of a Myelodysplastic Syndrome (MDS)

Author

Stelljes, Matthias, primary, Trenschel, Rudolf, additional, Beelen, Dietrich Wilhelm, additional, Markiewicz, Miroslaw, additional, Wagner, Eva Maria, additional, Bethge, Wolfgang, additional, Remenyi, Peter, additional, Niederwieser, Dietger, additional, Grigoleit, Goetz, additional, Schaefer-Eckart, Kerstin, additional, Stölzel, Friedrich, additional, Ciceri, Fabio, additional, Dreger, Peter, additional, Junghanß, Christian, additional, Holler, Ernst, additional, Rambaldi, Alessandro, additional, Russo, Domenico, additional, Verbeek, Mareike, additional, Casper, Jochen, additional, Patriarca, Francesca, additional, Bieniaszewska, Maria, additional, Glass, Bertram, additional, Scheid, Christoph, additional, Basara, Nadezda, additional, Finke, Jürgen, additional, Hilgendorf, Inken, additional, Labussière-Wallet, Hélène, additional, Stuhler, Gernot, additional, and Schroeder, Thomas, additional

Published
2022
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20. Favourable Outcome after Treosulfan Based Conditioning in Patients Undergoing an Allogeneic Hematopoietic Cell Transplantation (alloHCT) for the Treatment of Acute Myleloid Leukaemia (AML): A Subgroup Analysis of the Randomized Phase III MC-Fludt.14/L Trial

Author

Stölzel, Friedrich, primary, Stelljes, Matthias, additional, Beelen, Dietrich Wilhelm, additional, Markiewicz, Miroslaw, additional, Remenyi, Peter, additional, Dreger, Peter, additional, Ciceri, Fabio, additional, Wagner-Drouet, Eva-Maria, additional, Junghanss, Christian, additional, Scheid, Christoph, additional, Patriarca, Francesca, additional, Socié, Gerard, additional, Hilgendorf, Inken, additional, Rambaldi, Alessandro, additional, Schaefer-Eckart, Kerstin, additional, Russo, Domenico, additional, Grigoleit, Goetz, additional, Wulf, Gerald, additional, Basara, Nadezda, additional, Glass, Bertram, additional, Stuhler, Gernot, additional, Bieniaszewska, Maria, additional, Casper, Jochen, additional, Holler, Ernst, additional, Benedetti, Fabio, additional, Iori, Anna Paola, additional, Trenschel, Rudolf, additional, and Bethge, Wolfgang, additional

Published
2022
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21. Pooled Allogenic Fecal Microbiotherapy MaaT013 for the Treatment of Steroid-Refractory Gastrointestinal Acute Graft-Versus-Host Disease: Results from the Phase IIa Heracles Study and Expanded Access Program

Author

Malard, Florent, primary, Loschi, Michael, additional, Cluzeau, Thomas, additional, Huynh, Anne, additional, Guenounou, Sarah, additional, Borel, Cecile, additional, Legrand, Faezeh, additional, Granata, Angela, additional, Devillier, Raynier, additional, Maisano, Valerio, additional, Magro, Leonardo, additional, Orvain, Corentin, additional, Charbonnier, Amandine, additional, Panz-Klapuch, Marta, additional, Markiewicz, Miroslaw, additional, Desmier, Deborah, additional, Moya, Niels, additional, Mear, Jean-Baptiste, additional, Lhomme, Faustine, additional, Le Jeune, Caroline, additional, Cornillon, Jérôme, additional, Robin, Christine, additional, Holler, Ernst, additional, Daguindau, Etienne, additional, Bilger, Karin, additional, Vehreschild, Maria, additional, Le Bourgeois, Amandine, additional, Chevallier, Patrice, additional, Labussière-Wallet, Hélène, additional, Martineau, Delphine, additional, Couturier, Marie-Anne, additional, Bulabois, Claude-Eric, additional, Lanic, Helene, additional, Camus, Vincent, additional, Chantepie, Sylvain, additional, Ceballos, Patrice, additional, Gasc, Cyrielle, additional, Plantamura, Emilie, additional, and Mohty, Mohamad, additional

Published
2021
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22. Mild chronic graft-versus-host disease may alleviate poor prognosis associated with FLT3 internal tandem duplication for adult acute myeloid leukemia following allogeneic stem cell transplantation with myeloablative conditioning in first complete remission: a retrospective study

Author

Nasilowska-Adamska, Barbara, Czyz, Anna, Markiewicz, Miroslaw, Rzepecki, Piotr, Piatkowska-Jakubas, Beata, Paluszewska, Monika, Dzierzak-Mietla, Monika, Solarska, Iwona, Borg, Katarzyna, Prochorec-Sobieszek, Monika, Szydlo, Richard, Lewandowski, Krzysztof, Skotnicki, Aleksander, Jedrzejczak, Wieslaw Wiktor, Kyrcz-Krzemien, Slawomira, Komarnicki, Mieczyslaw, and Warzocha, Krzysztof

Published
2016
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25. Expression quantitative trait loci of genes predicting outcome are associated with survival of multiple myeloma patients

Author

Macauda, Angelica, primary, Piredda, Chiara, additional, Clay‐Gilmour, Alyssa I., additional, Sainz, Juan, additional, Buda, Gabriele, additional, Markiewicz, Miroslaw, additional, Barington, Torben, additional, Ziv, Elad, additional, Hildebrandt, Michelle A. T., additional, Belachew, Alem A., additional, Varkonyi, Judit, additional, Prejzner, Witold, additional, Druzd‐Sitek, Agnieszka, additional, Spinelli, John, additional, Andersen, Niels Frost, additional, Hofmann, Jonathan N., additional, Dudziński, Marek, additional, Martinez‐Lopez, Joaquin, additional, Iskierka‐Jazdzewska, Elzbieta, additional, Milne, Roger L., additional, Mazur, Grzegorz, additional, Giles, Graham G., additional, Ebbesen, Lene Hyldahl, additional, Rymko, Marcin, additional, Jamroziak, Krzysztof, additional, Subocz, Edyta, additional, Reis, Rui Manuel, additional, Garcia‐Sanz, Ramon, additional, Suska, Anna, additional, Haastrup, Eva Kannik, additional, Zawirska, Daria, additional, Grzasko, Norbert, additional, Vangsted, Annette Juul, additional, Dumontet, Charles, additional, Kruszewski, Marcin, additional, Dutka, Magdalena, additional, Camp, Nicola J., additional, Waller, Rosalie G., additional, Tomczak, Waldemar, additional, Pelosini, Matteo, additional, Raźny, Małgorzata, additional, Marques, Herlander, additional, Abildgaard, Niels, additional, Wątek, Marzena, additional, Jurczyszyn, Artur, additional, Brown, Elizabeth E., additional, Berndt, Sonja, additional, Butrym, Aleksandra, additional, Vachon, Celine M., additional, Norman, Aaron D., additional, Slager, Susan L., additional, Gemignani, Federica, additional, Canzian, Federico, additional, and Campa, Daniele, additional

Published
2021
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27. Early Mortality in Patients with Multiple Myeloma Treated with Novel Agents - Analysis from Polish Myeloma Study Group

Author

Charlinski, Grzegorz, primary, Tyczyńska, Agata, additional, Zaucha, Jan M, additional, Czyz, Adriana, additional, Czyż, Jarosław, additional, Dytfeld, Dominik, additional, Malecki, Bartosz, additional, Gil, Lidia, additional, Fornagiel, Szymon, additional, Grosicki, Sebastian, additional, Barchnicka, Agnieszka, additional, Holojda, Jadwiga, additional, Kolkowska, Agnieszka, additional, Hus, Iwona, additional, Helbig, Grzegorz, additional, Kopinska, Anna, additional, Masternak, Anna, additional, Woszczyk, Dariusz, additional, Markiewicz, Miroslaw, additional, Piszcz, Jaroslaw, additional, Kloczko, Janusz, additional, Usnarska-Zubkiewicz, Lidia, additional, Wrobel, Tomasz, additional, Robak, Pawel J., additional, Robak, Tadeusz, additional, Waszczuk-Gajda, Anna, additional, Basak, Grzegorz, additional, and Jurczyszyn, Artur, additional

Published
2020
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28. Comparison of a New Reduced Toxicity Myeloablative Treosulfan and Fludarabine Preparative Regimen with Myeloablative Busulfan or Melphalan in Combination with Fludarabine in Older Patients with Acute Myeloid Leukemia or Myelodysplastic Syndromes: A Retrospective Matched Pair Analysis of Patients from a Prospective Randomized Trial and the European Blood and Marrow Transplantation Society Registry

Author

Beelen, Dietrich W., primary, Iacobelli, Simona, additional, Koster, Linda, additional, Eikema, Dirk-Jan, additional, van Biezen, Anja, additional, Stoelzel, Friedrich, additional, Ciceri, Fabio, additional, Bethge, Wolfgang, additional, Dreger, Peter, additional, Wagner, Eva-Maria, additional, Reményi, Péter, additional, Stelljes, Matthias, additional, and Markiewicz, Miroslaw, additional

Published
2019
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29. Activating killer immunoglobulin-like receptor incompatibilities enhance graft-versus-host disease and affect survival after allogeneic hematopoietic stem cell transplantation

Author

Giebel, Sebastian, Nowak, Izabela, Dziaczkowska, Joanna, Czerw, Tomasz, Wojnar, Jerzy, Krawczyk-Kulis, Malgorzata, Holowiecki, Jerzy, Holowiecka-Goral, Aleksandra, Markiewicz, Miroslaw, Kopera, Malgorzata, Karolczyk, Agnieszka, Kyrcz-Krzemien, Slawomira, and Kusnierczyk, Piotr

Published
2009
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32. 94 - Favourable Outcome after Treosulfan Based Conditioning in Patients Undergoing an Allogeneic Hematopoietic Cell Transplantation (alloHCT) for the Treatment of Acute Myleloid Leukaemia (AML): A Subgroup Analysis of the Randomized Phase III MC-Fludt.14/L Trial

Author

Stölzel, Friedrich, Stelljes, Matthias, Beelen, Dietrich Wilhelm, Markiewicz, Miroslaw, Remenyi, Peter, Dreger, Peter, Ciceri, Fabio, Wagner-Drouet, Eva-Maria, Junghanss, Christian, Scheid, Christoph, Patriarca, Francesca, Socié, Gerard, Hilgendorf, Inken, Rambaldi, Alessandro, Schaefer-Eckart, Kerstin, Russo, Domenico, Grigoleit, Goetz, Wulf, Gerald, Basara, Nadezda, Glass, Bertram, Stuhler, Gernot, Bieniaszewska, Maria, Casper, Jochen, Holler, Ernst, Benedetti, Fabio, Iori, Anna Paola, Trenschel, Rudolf, and Bethge, Wolfgang

Published
2022
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33. 42 - Favourable Outcome after Treosulfan Based Conditioning of Patients Receiving an Allogeneic Hematopoietic Cell Transplantation (AlloHCT) for the Treatment of a Myelodysplastic Syndrome (MDS)

Author

Stelljes, Matthias, Trenschel, Rudolf, Beelen, Dietrich Wilhelm, Markiewicz, Miroslaw, Wagner, Eva Maria, Bethge, Wolfgang, Remenyi, Peter, Niederwieser, Dietger, Grigoleit, Goetz, Schaefer-Eckart, Kerstin, Stölzel, Friedrich, Ciceri, Fabio, Dreger, Peter, Junghanß, Christian, Holler, Ernst, Rambaldi, Alessandro, Russo, Domenico, Verbeek, Mareike, Casper, Jochen, Patriarca, Francesca, Bieniaszewska, Maria, Glass, Bertram, Scheid, Christoph, Basara, Nadezda, Finke, Jürgen, Hilgendorf, Inken, Labussière-Wallet, Hélène, Stuhler, Gernot, and Schroeder, Thomas

Published
2022
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34. Transplant-related prediction of survival in primary myelofibrosis : a study by the EBMT

Author

Gagelmann, Nico, Chalandon, Yves, Wang, Junfeng, de Wreede, Liesbeth, Wolschke, Christine, Van Lint, Maria Teresa, Beelen, Dietrich, Socié, Gerard, Stuhler, Gernot, Vitek, Antonin, Ehninger, Gerhard, Niederwieser, Dietger, Einsele, Herman, Markiewicz, Miroslaw, Arnold, Renate, Yakoub-Agha, Ibrahim, Robinson, Stephen, Reményi, Péter, Passweg, Jakob, Sengeloev, Henrik, Poiré, Xavier, Petersen, Eefke, Dreger, Peter, Kröger, Nicolaus, and Robin, Marie

Subjects
Medizin
Published
2018

36. Final Evaluation of a Clinical Phase III Trial Comparing Treosulfan to Busulfan-Based Conditioning Therapy Prior to Allogeneic Hematopoietic Stem Cell Transplantation of Adult Acute Myeloid Leukemia and Myelodysplastic Syndrome Patients Ineligible to Standard Myeloablative Regimens

Author

Beelen, Dietrich, primary, Markiewicz, Miroslaw, additional, Stelljes, Matthias, additional, Remenyi, Peter, additional, Wagner-Drouet, Eva-Maria, additional, Dreger, Peter, additional, Bethge, Wolfgang, additional, Ciceri, Fabio, additional, Stölzel, Friedrich, additional, Junghanß, Christian, additional, Michallet, Mauricette, additional, Schaefer-Eckart, Kerstin, additional, Grigoleit, Goetz, additional, Scheid, Christof, additional, Patriarca, Francesca, additional, Mico, Maria Caterina, additional, Niederwieser, Dietger, additional, Hilgendorf, Inken, additional, Russo, Domenico, additional, Socié, Gerard, additional, Holler, Ernst, additional, Glass, Bertram, additional, Wulf, Gerald, additional, Basara, Nadezda, additional, Hellmann, Andrzej, additional, Stuhler, Gernot, additional, Verbeek, Mareike, additional, Iori, Anna Paola, additional, Finke, Jürgen, additional, Benedetti, Fabio, additional, and Casper, Jochen, additional

Published
2019
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37. Stem cell transplantation for congenital dyserythropoietic anemia: an analysis from the European Society for Blood and Marrow Transplantation

Author

Miano, Maurizio, primary, Eikema, Dirk-Jan, additional, Aljurf, Mahmoud, additional, van’t Veer, Pieter J., additional, Öztürk, Gülyüz, additional, Wölfl, Matthias, additional, Smiers, Frans, additional, Schulz, Angsar, additional, Socié, Gerard, additional, Vettenranta, Kim, additional, de Heredia, Cristina Diaz, additional, Zecca, Marco, additional, Maertens, Johan, additional, Rovira, Montserrat, additional, Sierra, Jorge, additional, Uckan-Cetinkaya, Duygu, additional, Skorobogatova, Elena, additional, Antmen, Ali Bülent, additional, Dalle, Jean-Hugues, additional, Markiewicz, Miroslaw, additional, Hamladji, Rose Marie, additional, Kitra-Roussou, Vassiliki, additional, La Nasa, Giorgio, additional, Kriván, Gergely, additional, Al-Seiraihy, Amal, additional, Giardino, Stefano, additional, Risitano, Antonio Maria, additional, de Latour, Regis Peffault, additional, and Dufour, Carlo, additional

Published
2019
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38. Effects of trans-endocardial delivery of bone marrow-derived CD133+ cells on angina and quality of life in patients with refractory angina: A sub-analysis of the REGENT-VSEL trial

Author

Jadczyk, Tomasz, primary, Ciosek, Joanna, additional, Michalewska-Wludarczyk, Aleksandra, additional, Szot, Wojciech, additional, Parma, Zofia, additional, Ochala, Beata, additional, Markiewicz, Miroslaw, additional, Rychlik, Wojciech, additional, Kostkiewicz, Magdalena, additional, Gruszczynska, Katarzyna, additional, Blach, Anna, additional, Dzierzak-Mietla, Monika, additional, Rzeszutko, Lukasz, additional, Partyka, Lukasz, additional, Zasada, Wojciech, additional, Smolka, Grzegorz, additional, Pawlowski, Tomasz, additional, Jedrzejek, Marek, additional, Starek, Zdenek, additional, Plens, Krzysztof, additional, Ochala, Andrzej, additional, Tendera, Michal, additional, and Wojakowski, Wojciech, additional

Published
2018
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39. Inherited variation in the xenobiotic transporter pathway and survival of multiple myeloma patients

Author

Macauda, Angelica, primary, Castelli, Eleonora, additional, Buda, Gabriele, additional, Pelosini, Matteo, additional, Butrym, Aleksandra, additional, Watek, Marzena, additional, Kruszewski, Marcin, additional, Vangsted, Annette Juul, additional, Rymko, Marcin, additional, Jamroziak, Krzysztof, additional, Abildgaard, Niels, additional, Haastrup, Eva Kannik, additional, Mazur, Grzegorz, additional, Ríos, Rafael, additional, Jurczyszyn, Artur, additional, Zawirska, Daria, additional, Dudziński, Marek, additional, Raźny, Małgorzata, additional, Dutka, Magdalena, additional, Tomczak, Waldemar, additional, Suska, Anna, additional, Druzd-Sitek, Agnieszka, additional, Marques, Herlander, additional, Petrini, Mario, additional, Markiewicz, Miroslaw, additional, Martinez-Lopez, Joaquin, additional, Ebbesen, Lene Hyldahl, additional, Iskierka-Jażdżewska, Elżbieta, additional, Sainz, Juan, additional, Canzian, Federico, additional, and Campa, Daniele, additional

Published
2018
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42. Treosulfan-Based Conditioning Prior to Allogeneic Hematopoietic Stem Cell Transplantation (alloHSCT) for Patients with Myelodysplastic Syndrome (MDS): Comparative Analysis of a Randomized Controlled Trial and Real-World Data

Author

Stelljes, Matthias, Sockel, Katja, Floeth, Matthias, Schetelig, Johannes, Bornhäuser, Martin, Reicherts, Christian, Lenz, Georg, Schröder, Thomas, Trenschel, Rudolf, Markiewicz, Miroslaw, Labussière-Wallet, Hélène, Reményi, Péter, Ciceri, Fabio, and Stölzel, Friedrich

Abstract

Introduction

Published
2023
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43. Coexistence of Chronic Lymphocytic Leukemia and Myeloproliferative Neoplasm

Author

Zielinska, Patrycja, Markiewicz, Miroslaw, Dzierzak-Mietla, Monika, Koclega, Anna, Helbig, Grzegorz, and Kyrcz-Krzemien, Slawomira

Subjects
Article Subject, hemic and lymphatic diseases
Abstract

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the Western world. Host immune surveillance caused mainly by the disease itself is speculated to be responsible for high incidence of secondary neoplasms. However, the simultaneous occurrence of CLL and myeloproliferative disorder in the same patient is extremely rare. In the present report, a case of an 81-year-old man who was diagnosed with chronic lymphocytic leukemia and concomitant essential thrombocythemia is presented. We describe the morphologic, immunophenotypic, cytogenetic, and molecular findings in this patient. We also review the current literature.

Published
2014
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45. The Influence of Genetic Variations in the Gene on the Outcome after Allogeneic Hematopoietic Stem Cell Transplantation.

Author

Karabon, Lidia, Markiewicz, Miroslaw, Chrobot, Karolina, Dzierzak-Mietla, Monika, Pawlak-Adamska, Edyta, Partyka, Anna, Koclega, Anna, Kyrcz-Krzemien, Slawomira, and Frydecka, Irena

Subjects
*HUMAN genetic variation, *CD86 antigen, *HEMATOPOIETIC stem cell transplantation, *IMMUNOREGULATION, *SINGLE nucleotide polymorphisms
Abstract

CD86 molecule is the ligand for both costimulatory (CD28) and coinhibitory (CTLA-4) molecules, and it regulates immune response after allogeneic hematopoietic stem cell transplantation (alloHSCT). Therefore, we postulate that CD86 gene variations might influence the outcome after alloHSCT. Altogether, 295 adult patients (pts) undergoing related (105 pts) and unrelated (190 pts) donor-matched HSCT were genotyped for the following CD86 gene polymorphisms: rs1129055, rs9831894, and rs2715267. Moreover, the donors' rs1129055 polymorphism was determined. None of the investigated SNPs alone were associated with aGvHD and rate of relapse. However, we showed that rs2715267 SNP influenced overall survival (OS) after alloHSCT. The 24-month OS for the rs271526GG recipients was worse than that for the recipients possessing T allelle (TT or GT genotypes) (p = 0.009). Moreover, analysis of gene-gene interaction between CD86 and CTLA-4 showed that having both the A allele for CD86 rs1129055 and the CTLA-4 CT60GG genotype in recipients increased the risk of aGvHD about 3.5 times. Interestingly, the donors' rs1129055GG genotype and the recipients' CT60GG genotype also increased the risk of aGvHD about 2.7-fold. We postulate that recipients' CD86 gene polymorphisms influence the overall survival after alloHSCT and, together with CTLA-4 polymorphisms, might be considered a risk factor for aGvHD. [ABSTRACT FROM AUTHOR]

Published
2018
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46. Allogeneic Hematopoietic Cell Transplantation for Paroxysmal Nocturnal Hemoglobinuria

Author

Bialas Krzysztof, Frankiewicz Andrzej, Kyrcz-Krzemien Slawomira, Markiewicz Miroslaw, Sobczyk-Kruszelnicka Malgorzata, Zielinska Patrycja, Dzierzak-Mietla Monika, and Koclega Anna

Subjects
Transplantation, Hematopoietic cell, business.industry, hemic and lymphatic diseases, Immunology, Paroxysmal nocturnal hemoglobinuria, medicine, medicine.disease, business
Published
2012

47. Final Results of a Prospective Randomized Multicenter Phase III Trial Comparing Treosulfan/Fludarabine to Reduced Intensity Conditioning with Busulfan/Fludarabine Prior to Allogeneic Hematopoietic Stem Cell Transplantation in Elderly or Comorbid Patients with Acute Myeloid Leukemia or Myelodysplastic Syndrome

Author

Beelen, Dietrich W, Trenschel, Rudolf, Stelljes, Matthias, Masszi, Tamás, Reményi, Péter, Wagner-Drouet, Eva-Maria Maria, Dreger, Peter, Bethge, Wolfgang, Ciceri, Fabio, Stoelzel, Friedrich, Junghanss, Christian, Michallet, Mauricette, and Markiewicz, Miroslaw

Published
2017
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48. Mild chronic graft-versus-host disease may alleviate poor prognosis associated with FLT3 internal tandem duplication for adult acute myeloid leukemia following allogeneic stem cell transplantation with myeloablative conditioning in first complete remissio

Author

Nasilowska-Adamska, Barbara, primary, Czyz, Anna, additional, Markiewicz, Miroslaw, additional, Rzepecki, Piotr, additional, Piatkowska-Jakubas, Beata, additional, Paluszewska, Monika, additional, Dzierzak-Mietla, Monika, additional, Solarska, Iwona, additional, Borg, Katarzyna, additional, Prochorec-Sobieszek, Monika, additional, Szydlo, Richard, additional, Lewandowski, Krzysztof, additional, Skotnicki, Aleksander, additional, Jedrzejczak, Wieslaw Wiktor, additional, Kyrcz-Krzemien, Slawomira, additional, Komarnicki, Mieczyslaw, additional, and Warzocha, Krzysztof, additional

Published
2015
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49. Safety and outcome of allogeneic stem cell transplantation in myelofibrosis

Author

Markiewicz, Miroslaw, primary, Dzierzak Mietla, Monika, additional, Wieczorkiewicz, Agata, additional, Mizia, Sylwia, additional, Helbig, Grzegorz, additional, Kopera, Malgorzata, additional, Bialas, Krzysztof, additional, Rybicka, Malwina, additional, Matyja, Mariusz, additional, Koclega, Anna, additional, Sedlak, Lech, additional, Oleksy, Tomasz, additional, Raman, Sundar, additional, and Kyrcz-Krzemien, Slawomira, additional

Published
2015
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50. Pretransplant donor and recipient CTLA-4 mRNA and protein levels as a prognostic marker for aGvHD in allogeneic hematopoietic stem cell transplantation

Author

Karabon, Lidia, primary, Markiewicz, Miroslaw, additional, Kosmaczewska, Agata, additional, Partyka, Anna, additional, Pawlak-Adamska, Edyta, additional, Tomkiewicz, Anna, additional, Ciszak, Lidia, additional, Jagoda, Krystyna, additional, Dzierzak-Mietla, Monika, additional, Kyrcz-Krzemien, Slawomira, additional, and Frydecka, Irena, additional

Published
2015
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