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The aim of this paper is to gain insight into changes in the provision of services in the system of protection of migrants and asylum seekers and to map the challenges in the implementation of joint activities of the public and civil sector in the Republic of Serbia. A survey was conducted with actors in the system of protection of refugees and migrants. The methodology used includes empirical research to analyze and understand the functions of the public and civil sectors during the Covid-19 pandemic in the system of protection of migrants and asylum seekers. Two focus groups with fourteen professionals and six interviews with key stakeholders were conducted, focusing on cooperation between different protection systems and changes in their activities. The results show that experts faced numerous challenges duringand after the suspension of the state of emergency, which affected the lack of adequate cooperation with the health, education and legal systems, as well as the cessation of civil society activities in asylum centers and reception centers. The pandemic shed light on existing systemic problems and created new challenges in public-civil cooperation.

Introduced measures to deal with COVID-19 pandemic in Serbia affected everyday life of people. Media coverage during the pandemic played a significant role in providing verified information, protecting human health and well-being. In order to gain insight into the reactions of social work students on introduced measures and media coverage about these measures during the state of emergency in Republic of Serbia, an analysis of reflective journals is presented. Eighty reflective journals were analyzed, where students' reactions on introduced measures and media coverage related to these measures are monitored and linked to the electronic archive of the public media service Radio Television of Serbia news. Students' thoughts on several identified measures are presented and analyzed together with their reactions on media coverage about these measures. Findings indicate the important role of the content and ways of media reporting in creation of reflections, as well as the importance of using reflective journals in both education and preservation of mental health. Possible directions of mental health improvement through media coverage in crisis situations and recommendations for education of social workers are presented., Mjere koje su uvedene zbog pandemije COVID-19 u Srbiji utjecali su na svakodnevni život ljudi. Medijsko izvještavanju tijekom pandemije odigralo je značajnu ulogu u pružanju provjerenih informacija i zaštiti ljudskih prava i dobrobiti. Kako bi se stekao uvid u reakcije studenata socijalnog rada na uvedene mjere i medijsko izvješćivanje o tim mjerama tijekom izvanrednog stanja u Republici Srbiji, u radu se predstavlja analiza refleksivnih dnevnika. Analizirano je osamdeset refleksivnih dnevnika putem kojih su se reakcije studenata na uvedene mjere i na medijsko izvješćivanje povezano s tim mjerama pratile i povezivale s elektronskom arhivom javne medijske usluge novosti Radio Televizije Srbije. Studentska mišljenja o nekoliko uvedenih mjera se prikazuju i analiziraju zajedno s njihovim reakcijama na medijsko izvještavanje o tim mjerama. Rezultati ukazuju na važnu ulogu sadržaja i načina medijskog izvještavanja u stvaranju mišljenja, kao i na važnost korištenja refleksivnih dnevnika u obrazovanju i u očuvanju duševnog zdravlja. Predstavljaju se moguće smjernice za poboljšanje duševnog zdravlja putem medijskog izvještavanja tijeom izvanrednog stanja kao i preporuke za obrazovanje socijalnih radnika.

Pandemija virusa Kovid 19 dovela je do promena u svakodnevnici ljudi i proizvela osećaje nesigurnosti i anksioznosti koji mogu imati negativne posledice na učenje i psihološko zdravlje studenata. Prelaskom na online nastavu na Fakultetu političkih nauka Univerziteta u Beogradu, za studente socijalne politike i socijalnog rada uvedena je predispitna obaveza pisanja refleksivnih dnevnika sa ciljem da se identifikuju, prepoznaju i osveste sopstvene reakcije i doživljaji vezani za pandemiju i podstakne introspekcija i kritičko mišljenje studenata. Cilj rada je analiza dobijenih podataka radi dobijanja informacija o doživljaju studenata i reakcijama na pandemiju virusa Kovid 19 kako bi se stekle informacije o suočavanju sa situacijom pandemije ali i kreirale intervencije radi očuvanja i unapređenja mentalnog zdravlja studentske populacije. Primenjena je tematska analiza dnevnika u kojima su indetifkovane teme: odnos prema pisanju dnevnika, sagledavanje dobrih aspekata vanrednog stanja, porodični odnosi, variranje raspoloženja, odnos prema jelu i pripremi hrane, stvaranje strukture, razvoj kreativnosti, anksioznost, depresivna stanja, bes i strah. Rezultati ukazuju na značaj negovanja i očuvanja mentalnog zdravlja za dobrobit ljudi i na moguće pravce unapređenja praksi obrazovnih ustanova u kriznim situacijama. The pandemic of the novel corona virus has led to changes in people’s daily lives and has produced feelings of insecurity and anxiety that can have neg- ative consequences for students’ learning and psychological health. Upon switching to online teaching at the Faculty of Political Science, University of Belgrade, a pre-examination task of writing reflective diaries was introduced for students of social politics and social work on two subjects: Counseling and Sociotherapy and Social Work with Children and Youth. The aim of the task was to identify, but also recognize and raise awareness of reactions and experiences related to the pandemic and encourage introspec- tion. The thematic analysis of 80 reflective diaries and selected topics were presented: attitude towards writing diaries, understanding the good aspects of the state of emergency, family relations, mood swings, attitude towards eating and food preparation, creating structure, developing creativity, anx- iety, depression, anger and fear. The results indicate the importance of nur- turing and preserving mental health for the well-being of people and the possible directions for improving the practice of educational institutions in crisis situations.

Eight 1,3,4-oxadiazole derivatives containing phenolic acid moieties (7a–h) and eight of their diacylhydrazine precursors (6a–h) were synthesized, characterized using spectroscopic methods and examined by scavenging of stable DPPH (2,2-diphenyl-1-picrylhydrazyl) radicals. The most potent phenolic 1,3,4-oxadiazoles showed better DPPH scavenging activity in comparison with their corresponding diacylhydrazine precursors as a result of participation of both aromatic rings and a 1,3,4-oxadiazole moiety in resonance stabilization of the formed phenoxyl radical. Four diacylhydrazines (6d, 6e, 6g, and 6h) and four 1,3,4-oxadiazoles (7d, 7e, 7g and 7h) with the best DPPH scavenging activity, were chosen for further evaluation of their antioxidant potential through various assays. The investigated compounds exerted pronounced ABTS radical scavenging capacity, moderate to good H2O2 scavenging properties and strong ferric ion reducing capacity. Further in vitro evaluation of the antioxidant properties of the most active compounds demonstrated their protective effects in normal lung fibroblasts MRC-5 against hydrogen peroxide induced oxidative stress. Diacylhydrazine 6h increased two times the activity of glutathione peroxidase in treated cells in comparison with a control sample and did not affect the superoxide dismutase activity.

U okviru ove disertacije opisani su sinteza, strukturna karakterizacija i rezultati ispitivanja antioksidativne i citotoksične aktivnosti novih derivata 1,3,4-tiadiazola koji u svojoj strukturi sadrže fenolne hidroksilne grupe. U cilju određivanja mehanizma antitumorskog delovanja, za odabrana jedinjenja izvršena su dodatna ispitivanja poput analize raspodele faza ćelijskog ciklusa, ispitivanja uticaja na stvaranje ROS-a u malignim ćelijama usled dejstva vodonik-peroksida, morfološke analize tipa ćelijske smrti, određivanja ciljnih kaspaza, analize ekspresije gena, kao i ispitivanja interakcija sa DNK. Sintetizovane su tri serije jedinjenja koje ukupno sadrže 44 amidna derivata 1,3,4-tiadiazola, polazeći od fenolnih kiselina. Prve dve serije amida sintetizovane su kuplovanjem 5-supstituisanih-2-amino-1,3,4-tiadiazola izvedenih iz fenolnih kiselina sa različitim hloridima kiselina, koji su u slučaju serije B u svojoj strukturi sadržali i halkonsku jedinicu. Treća serija amidnih derivata dobijena je reakcijom hlorida fenolne kiseline sa supstituisanim 2-amino-1,3,4- tiadiazolima. Sva novosintetizovana jedinjenja strukturno su okarakterisana primenom NMR i IR spektroskopskih metoda. Antioksidativna aktivnost svih sintetizovanih 1,3,4-tiadiazolskih derivata ispitana je primenom DPPH metode, a dobijeni rezultati upoređeni su sa poznatim antioksidantima, askorbinskom i/ili nordihidrogvajaretinskom kiselinom. Jedinjenja sve tri serije pokazala su umerenu do dobru aktivnost neutralisanja DPPH radikala. Antioksidativni kapacitet sintetizovanih jedinjenja može se objasniti mogućnošću stabilizacije radikala, formiranog nakon apstrakcije vodonikovog atoma DPPH radikalom, delokalizacijom nesparenog elektrona preko 1,3,4- tiadiazolskog prstena. Ispitana je i aktivnost neutralisanja ABTS radikal-katjona amidnih derivata serije V, a dobijeni rezultati su pokazali da sintetizovana jedinjenja, pored kapaciteta za neutralizaciju DPPH radikala, imaju bolju sposobnost neutralisanja ABTS radikal-katjona u odnosu na askorbinsku kiselinu, NDGA i polaznu 3,4-dihidroksibenzojevu kiselinu. Within this study, the synthesis, structural characterization, and evaluation of the antioxidant and cytotoxic activities of novel 1,3,4-thiadiazole derivatives containing phenolic hydroxyl groups in their structure were described. In order to elucidate the mechanism of the antitumor activity, additional tests were performed for the selected compounds, such as cell cycle phase distribution analysis, investigation of their influence on ROS generation in malignant cells due to the action of hydrogen peroxide, cell death type morphology analysis, target caspase determination, gene expression analysis, and DNA interaction assays. Three series containing a total of 44 1,3,4-thiadiazole amide derivatives were synthesized starting from phenolic acids. The first two series of amides were synthesized by coupling 5-substituted-2-amino-1,3,4-thiadiazoles derived from phenolic acids with different acid chlorides, which in the case of series Б contained a chalcone unit in their structure. The third series of amide derivatives was obtained by the reaction of the phenolic acid chloride with substituted 2-amino-1,3,4-thiadiazoles. All newly synthesized compounds were structurally characterized using NMR and IR spectroscopic methods. The antioxidant activity of all synthesized 1,3,4-thiadiazole derivatives was examined using the DPPH method, and the obtained results were compared with well-known antioxidants, ascorbic and/or nordihydroguaiaretic acid. Compounds of all three series showed moderate to good DPPH radical scavenging activity. The antioxidant capacity of the synthesized compounds can be explained by the possibility of stabilizing the radical formed after abstraction of the hydrogen atom by the DPPH radical, via delocalization of the unpaired electron across the 1,3,4-thiadiazole ring. ABTS radical cation scavenging activity of amide derivatives of series В was also investigated and the obtained results showed that the synthesized compounds, in addition to the DPPH radical scavenging capacity, have a better ABTS radical cation scavenging ability compared to ascorbic acid, NDGA and starting 3,4-dihydroxybenzoic acid.