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541 results on '"Marktel, Sarah"'

1. A Novel Assay in Whole Blood Demonstrates Restoration of Mitochondrial Activity in Phagocytes After Successful HSCT in Hyperinflamed X-Linked Chronic Granulomatous Disease

Author

Migliavacca, Maddalena, Basso Ricci, Luca, Farinelli, Giada, Calbi, Valeria, Tucci, Francesca, Barzaghi, Federica, Ferrua, Francesca, Cicalese, Maria Pia, Darin, Silvia, Barzaghi, Lina Raffaella, Giglio, Fabio, Peccatori, Jacopo, Fumagalli, Francesca, Nicoletti, Roberto, Giannelli, Stefania, Sartirana, Claudia, Bandiera, Alessandro, Esposito, Maria, Milani, Raffaella, Mazzi, Benedetta, Finocchi, Andrea, Marktel, Sarah, Assanelli, Andrea, Locatelli, Franco, Ciceri, Fabio, Aiuti, Alessandro, and Bernardo, Maria Ester

Published
2022
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2. Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress

Author

Montaldo, Elisa, Lusito, Eleonora, Bianchessi, Valentina, Caronni, Nicoletta, Scala, Serena, Basso-Ricci, Luca, Cantaffa, Carla, Masserdotti, Alice, Barilaro, Mattia, Barresi, Simona, Genua, Marco, Vittoria, Francesco Maria, Barbiera, Giulia, Lazarevic, Dejan, Messina, Carlo, Xue, Elisabetta, Marktel, Sarah, Tresoldi, Cristina, Milani, Raffaella, Ronchi, Paola, Gattillo, Salvatore, Santoleri, Luca, Di Micco, Raffaella, Ditadi, Andrea, Belfiori, Giulio, Aleotti, Francesca, Naldini, Matteo Maria, Gentner, Bernhard, Gardiman, Elisa, Tamassia, Nicola, Cassatella, Marco Antonio, Hidalgo, Andrés, Kwok, Immanuel, Ng, Lai Guan, Crippa, Stefano, Falconi, Massimo, Pettinella, Francesca, Scapini, Patrizia, Naldini, Luigi, Ciceri, Fabio, Aiuti, Alessandro, and Ostuni, Renato

Published
2022
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3. Association Between the Magnitude of Intravenous Busulfan Exposure and Development of Hepatic Veno-Occlusive Disease in Children and Young Adults Undergoing Myeloablative Allogeneic Hematopoietic Cell Transplantation

Author

Bognàr, Tim, Bartelink, Imke H., Egberts, Toine C.G., Rademaker, Carin M.A., Versluys, A. Birgitta, Slatter, Mary A., Kletzel, Morris, Nath, Christa E., Cuvelier, Geoffrey D.E, Savic, Rada M., Dvorak, Christopher, Long-Boyle, Janel R., Cowan, Morton J., Bittencourt, Henrique, Bredius, Robbert G.M., Güngör, Tayfun, Shaw, Peter J., Ansari, Marc, Hassan, Moustapha, Krajinovic, Maja, Hempel, Georg, Marktel, Sarah, Chiesa, Robert, Théoret, Yves, Lund, Troy, Orchard, Paul J., Wynn, Robert F., Boelens, Jaap Jan, and Lalmohamed, Arief

Published
2022
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4. Sorafenib maintenance in FLT3-ITD mutated AML after allogeneic HCT: a real-world, single-center experience.

Author

Diral, Elisa, Furnari, Giulia, Bruno, Alessandro, Greco, Raffaella, Clerici, Daniela, Marktel, Sarah, Farina, Francesca, Mastaglio, Sara, Vago, Luca, Piemontese, Simona, Peccatori, Jacopo, Corti, Consuelo, Bernardi, Massimo, Ciceri, Fabio, and Lupo-Stanghellini, Maria Teresa

Subjects
SORAFENIB, ACUTE myeloid leukemia, HEMATOPOIETIC stem cells, STEM cell transplantation, OVERALL survival
Abstract

Despite allogeneic hematopoietic stem cell transplant (allo-HCT) and the development of novel FLT3 inhibitors in both induction (midostaurin) and in the relapsed/refractory setting (gilteritinib), FLT3-ITD mutated leukemia (FLT3- ITD+ AML) still represents a challenge for modern hematology. Sorafenib is, to this date, the only inhibitor that demonstrated efficacy in improving both progression-free and overall survival as post-HCT maintenance therapy, even if its use in this setting has not been approved so far by regulatory agencies. The aim of our study was to evaluate the feasibility, safety, and efficacy of sorafenib maintenance in preventing early relapse in FLT3-ITD+ AML after HCT in a singlecenter experience. We analyzed 26 consecutive patients who received post-HCT 2-year maintenance with sorafenib at our center between 2017 and 2023. The median time from HCT to sorafenib start was 130 days, and the median dosage was 200 mg per day. Two (8%) and three (12%) patients discontinued maintenance due to toxicity and disease relapse, respectively. Eight (31%) patients terminated the 2-year maintenance and stopped sorafenib, while 13 patients are still under treatment. Overall, 21/26 patients (81%) are alive and in stable complete remission as outlined by a 2-year disease-free survival of 83.61%. No major long-term toxicity was reported at the last follow-up. Our real-world experience supports the use of sorafenib as a feasible and effective therapeutic option in post-HCT maintenance for FLT3-ITD+ AML. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Allogeneic hematopoietic stem cell transplantation in patients older than 65 years with acute myeloid leukemia and myelodysplastic syndrome: a 15-year experience

Author

Piemontese, Simona, Lazzari, Lorenzo, Ruggeri, Annalisa, Marcatti, Magda, Lupo Stanghellini, Maria Teresa, Giglio, Fabio, Greco, Raffaella, Lorentino, Francesca, Clerici, Daniela, Assanelli, Andrea, Farina, Francesca, Mastaglio, Sara, Xue, Elisabetta, Marktel, Sarah, Vago, Luca, Gentner, Bernhard, Secco, Chiara, Corti, Consuelo, Carrabba, Matteo Giovanni, Bernardi, Massimo, Peccatori, Jacopo, and Ciceri, Fabio

Published
2022
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6. COVID-19 in recipients of allogeneic stem cell transplantation: favorable outcome

Author

Lupo-Stanghellini, Maria Teresa, Xue, Elisabetta, Mastaglio, Sara, Oltolini, Chiara, Angelillo, Piera, Messina, Carlo, Piemontese, Simona, Girlanda, Stefania, Farina, Francesca, Lazzari, Lorenzo, Cicalese, Maria Pia, Erbella, Federico, Greco, Raffaella, Locatelli, Massimo, Milani, Raffaella, Peccatori, Jacopo, Corti, Consuelo, Marktel, Sarah, Assanelli, Andrea, and Ciceri, Fabio

Published
2021
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7. Association of busulfan exposure with survival and toxicity after haemopoietic cell transplantation in children and young adults: a multicentre, retrospective cohort analysis

Author

Bartelink, Imke H, Lalmohamed, Arief, van Reij, Elisabeth ML, Dvorak, Christopher C, Savic, Rada M, Zwaveling, Juliette, Bredius, Robbert GM, Egberts, Antoine CG, Bierings, Marc, Kletzel, Morris, Shaw, Peter J, Nath, Christa E, Hempel, George, Ansari, Marc, Krajinovic, Maja, Théorêt, Yves, Duval, Michel, Keizer, Ron J, Bittencourt, Henrique, Hassan, Moustapha, Güngör, Tayfun, Wynn, Robert F, Veys, Paul, Cuvelier, Geoff DE, Marktel, Sarah, Chiesa, Robert, Cowan, Morton J, Slatter, Mary A, Stricherz, Melisa K, Jennissen, Cathryn, Long-Boyle, Janel R, and Boelens, Jaap Jan

Subjects
Cancer, Transplantation, Good Health and Well Being, Adolescent, Adult, Area Under Curve, Busulfan, Child, Child, Preschool, Cohort Studies, Disease-Free Survival, Dose-Response Relationship, Drug, Female, Graft Rejection, Graft Survival, Graft vs Host Disease, Hematopoietic Stem Cell Transplantation, Humans, Infant, Male, Recurrence, Retrospective Studies, Transplantation Conditioning, Transplantation, Homologous, Treatment Outcome, Cardiorespiratory Medicine and Haematology, Clinical Sciences
Abstract

BackgroundIntravenous busulfan combined with therapeutic drug monitoring to guide dosing improves outcomes after allogeneic haemopoietic cell transplantation (HCT). The best method to estimate busulfan exposure and optimum exposure in children or young adults remains unclear. We therefore assessed three approaches to estimate intravenous busulfan exposure (expressed as cumulative area under the curve [AUC]) and associated busulfan AUC with clinical outcomes in children or young adults undergoing allogeneic HCT.MethodsIn this retrospective analysis, patients from 15 centres in the Netherlands, USA, Canada, Switzerland, UK, Italy, Germany, and Australia who received a busulfan-based conditioning regimen between March 18, 2001, and Feb 12, 2015, were included. Cumulative AUC was calculated by numerical integration using non-linear mixed effect modelling (AUCNONMEM), non-compartmental analysis (AUC from 0 to infinity [AUC0-∞] and to the next dose [AUC0-τ]), and by individual centres using various approaches (AUCcentre). The main outcome of interest was event-free survival. Other outcomes of interest were graft failure or relapse, or both; transplantation-related mortality; acute toxicity (veno-occlusive disease or acute graft versus-host disease [GvHD]); chronic GvHD; overall survival; and chronic-GvHD-free event-free survival. We used propensity-score-adjusted Cox proportional hazard models, Weibull models, and Fine-Gray competing risk regressions for statistical analyses.Findings790 patients were enrolled, 674 of whom were included: 274 (41%) with malignant and 400 (59%) with non-malignant disease. Median age was 4·5 years (IQR 1·4-10·7). The median busulfan AUCNONMEM was 74·4 mg × h/L (95% CI 31·1-104·6), which correlated with the standardised method AUC0-∞ (r2=0·74), but the latter correlated poorly with AUCcentre (r2=0·35). Estimated 2-year event-free survival was 69·7% (95% CI 66·2-73·0). Event-free survival at 2 years was 77·0% (95% CI 72·1-82·9) in the 257 patients with an optimum intravenous busulfan AUC of 78-101 mg × h/L compared with 66·1% (60·9-71·4) in the 235 patients at the low historical target of 58-86 mg × h/L and 49·5% (29·2-66·0) in the 44 patients with a high (>101 mg × h/L) busulfan AUC (p=0·011). Compared with the low AUC group, graft failure or relapse occurred less frequently in the optimum AUC group (hazard ratio [HR] 0·57, 95% CI 0·39-0·84; p=0·0041). Acute toxicity (HR 1·69, 1·12-2·57; p=0·013) and transplantation-related mortality (2·99, 1·82-4·92; p101 mg × h/L) than in the low AUC group (

Published
2016

8. Intrabone Transplantation of a Single Unwashed Umbilical Cord Blood Unit with Antithymocyte Globulin-Free and Sirolimus-Based Graft-versus-Host Disease Prophylaxis: Fast Immune Reconstitution and Long-Term Disease Control in Patients with High-Risk Diseases

Author

Giglio, Fabio, Xue, Elisabetta, Barone, Angelica, Lorentino, Francesca, Greco, Raffaella, Ruggeri, Annalisa, Zambelli, Matilde, Parisi, Cristina, Milani, Raffaella, Clerici, Daniela, Piemontese, Simona, Marktel, Sarah, Lazzari, Lorenzo, Marcatti, Magda, Bernardi, Massimo, Corti, Consuelo, Lupo-Stanghellini, Maria Teresa, Ciceri, Fabio, and Peccatori, Jacopo

Published
2023
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9. Bone marrow harvesting from paediatric patients undergoing haematopoietic stem cell gene therapy

Author

Tucci, Francesca, Frittoli, Marta, Barzaghi, Federica, Calbi, Valeria, Migliavacca, Maddalena, Ferrua, Francesca, Fumagalli, Francesca, Lorioli, Laura, Castagnaro, Laura, Facchini, Marcella, Fossati, Claudia, Zancan, Stefano, Massariello, Paola, Manfredini, Michele, Consiglieri, Giulia, Canarutto, Daniele, Recupero, Salvatore, Calzatini, Francesco, Casiraghi, Miriam, Darin, Silvia, Antonioli, Gigliola, Miniero, Roberto, Fiori, Rossana, Silvani, Paolo, Zambelli, Matilde, Marktel, Sarah, Gattillo, Salvatore, Milani, Raffaella, Santoleri, Luca, Ciceri, Fabio, Biffi, Alessandra, Cicalese, Maria Pia, Bernardo, Maria Ester, and Aiuti, Alessandro

Published
2019
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10. 3117 – HSCS IN Β-THALASSEMIA HAVE A REDUCED DORMANCY AND AN ERYTHROID BIASED LINEAGE COMMITMENT IN RESPONSE TO ALTERED TGFΒ SIGNALING IN THE BM MICROENVIRONMENT

Author

Lidonnici, Maria Rosa, Chianella, Giulia, Mende, Nicole, Bastos, Hugo, Barcella, Matteo, Merelli, Ivan, Storto, Mariangela, Romeo, Valentina, Scaramuzza, Samantha, Rossi, Claudia, Crippa, Stefania, Bernardo, Maria Ester, Ciceri, Fabio, Aiuti, Alessandro, Marktel, Sarah, Laurenti, Elisa, and Ferrari, Giuliana

Published
2024
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11. P1549: HIGH PREVALENCE OF RESPIRATORY SYNCYTIAL VIRUS IN HAEMATOLOGICAL PATIENTS AFTER COVID19 WAVES.

Author

Farina, Francesca, primary, Sannipoli, Daniele, additional, Oltolini, Chiara, additional, Diral, Elisa, additional, Marcatti, Magda, additional, Ferla, Valeria, additional, Canziani, Luca, additional, Xue, Elisabetta, additional, Greco, Raffaella, additional, Clerici, Daniela, additional, Bruno, Alessandro, additional, Marktel, Sarah, additional, Mastaglio, Sara, additional, Carrabba, Matteo, additional, Bernardi, Massimo, additional, Carmagnola, Anna, additional, Castagna, Antonella, additional, Scarpellini, Paolo, additional, Dell’acqua, Raffaele, additional, Ciceri, Fabio, additional, Peccatori, Jacopo, additional, Corti, Consuelo, additional, and Lupo Stanghellini, Maria Teresa, additional

Published
2023
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12. P965: STEM-CELL MOBILIZATION WITH CYCLOPHOSPHAMIDE 4 G/M2 ALLOWS COLLECTION OF HIGH NUMBERS OF CD34+ CELLS AFTER DARA-VTD INDUCTION FOR MULTIPLE MYELOMA

Author

Perini, Tommaso, primary, Liberatore, Carmine, additional, Virginia, Girlando, additional, Passeri, Cecilia, additional, Ferla, Valeria, additional, Iuliani, Ornella, additional, Orsini, Alessia, additional, Montanaro, Guido, additional, Farina, Francesca, additional, Nicola, Alessandro DI, additional, Marktel, Sarah, additional, Pulini, Stefano, additional, Santarone, Stella, additional, Accorsi, Patrizia, additional, Ciceri, Fabio, additional, Ianni, Mauro DI, additional, and Marcatti, Magda, additional

Published
2023
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13. P1572: COVID-19 MORTALITY IN HIGH-RISK PATIENTS AFTER ALLO-HSCT AND CAR-T: IMPROVED OUTCOME THROUGH A PANDEMIC.

Author

Sannipoli, Daniele, primary, Camilla, Gariazzo, additional, Farina, Francesca, additional, Diral, Elisa, additional, Bruno, Alessandro, additional, Clerici, Daniela, additional, Marktel, Sarah, additional, Canziani, Luca, additional, Catalano, Gloria, additional, Fiore, Paolo, additional, Oltolini, Chiara, additional, Querini, Patrizia Rovere, additional, Corti, Consuelo, additional, Ciceri, Fabio, additional, Vitali, Giordano, additional, and Lupo-Stanghellini, Maria Teresa, additional

Published
2023
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14. PB2426: SORAFENIB MAINTENANCE TAILORED TO FLT3-MUTATED AML AFTER ALLOGENEIC HCT IS HIGHLY FEASIBLE AND EFFECTIVE: A REAL-LIFE EXPERIENCE

Author

Diral, Elisa, primary, Furnari, Giulia, additional, Farina, Francesca, additional, Clerici, Daniela, additional, Marktel, Sarah, additional, Greco, Raffaella, additional, Catalano, Gloria, additional, Bruno, Alessandro, additional, Campodonico, Edoardo, additional, Xue, Elisabetta, additional, Mastaglio, Sara, additional, Vago, Luca, additional, Stefano Luca Bernardi, Massimo, additional, Carrabba, Matteo Giovanni, additional, Corti, Consuelo, additional, Peccatori, Jacopo, additional, Ciceri, Fabio, additional, and Teresa Lupo Stanghellini, Maria, additional

Published
2023
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15. PB2575: HIGH INCIDENCE OF RESPIRATORY TRACT INFECTIONS FOLLOWING COVID-19 WAVES IN PATIENTS WITH PLASMA CELL DYSCRASIAS

Author

Farina, Francesca, primary, Marktel, Sarah, additional, Ferla, Valeria, additional, Clerici, Daniela, additional, Daniele, Sannipoli, additional, Perini, Tommaso, additional, Catalano, Gloria, additional, Oltolini, Chiara, additional, Stanghellini, Maria Teresa Lupo, additional, Corti, Consuelo, additional, Ciceri, Fabio, additional, and Marcatti, Magda, additional

Published
2023
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16. Higher cyclophosphamide dose grants optimal stem cell collection after daratumumab-based induction in multiple myeloma

Author

Liberatore, Carmine, primary, Perini, Tommaso, additional, Passeri, Cecilia, additional, Ferla, Valeria, additional, Fioritoni, Francesca, additional, Girlando, Virginia, additional, Iuliani, Ornella, additional, Orsini, Alessia, additional, Montanaro, Guido, additional, Farina, Francesca, additional, Di Nicola, Alessandro, additional, Nitti, Rosamaria, additional, Pulini, Stefano, additional, Mastaglio, Sara, additional, Santarone, Stella, additional, Coppola, Milena, additional, Marktel, Sarah, additional, Accorsi, Patrizia, additional, Ciceri, Fabio, additional, Marcatti, Magda, additional, and Di Ianni, Mauro, additional

Published
2023
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17. Veno-occlusive Disease in HSCT Patients: Consensus-based Recommendations for Risk Assessment, Diagnosis, and Management by the GITMO Group

Author

Bonifazi, Francesca, Sica, Simona, Angeletti, Alessia, Marktel, Sarah, Prete, Arcangelo, Iori, Anna Paola, Olivari, Diletta, Rossetti, Giulia, Bertaina, Alice, Botti, Stefano, Busca, Alessandro, Carella, Angelo Michele, Cerretti, Raffaella, Gargiulo, Gianpaolo, Grassi, Anna, Gualandi, Francesca, Irrera, Giuseppe, Milone, Giuseppe, Risitano, Antonio Maria, Santarone, Stella, Vassallo, Elena, Zecca, Marco, Ciceri, Fabio, and Pomponio, Giovanni

Published
2020
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18. Bone marrow stromal cells from [beta]-thalassemia patients have impaired hematopoietic supportive capacity

Author

Crippa, Stefania, Rossella, Valeria, Aprile, Annamaria, Silvestri, Laura, Rivis, Silvia, Scaramuzza, Samantha, Pirroni, Stefania, Avanzini, Maria Antonietta, Basso-Ricci, Luca, Hernandez, Raisa Jofra, Zecca, Marco, Marktel, Sarah, Ciceri, Fabio, Aiuti, Alessandro, Ferrari, Giuliana, and Bernardo, Maria Ester

Subjects
Hematopoietic stem cell transplantation -- Usage, Oxidative stress -- Health aspects, Thalassemia -- Genetic aspects -- Care and treatment, Xenotransplantation -- Usage, Glycosylated hemoglobin, Bone marrow transplantation, Target marketing, Hydrogen sulfide, Hemoglobins, Homeostasis, Hematopoietic stem cells, Stem cells, Genes, Ferritin, Health care industry
Abstract

BACKGROUND. The human bone marrow (BM) niche contains a population of mesenchymal stromal cells (MSCs) that provide physical support and regulate hematopoietic stem cell (HSC) homeostasis. [beta]-Thalassemia (BT) is a hereditary disorder characterized by altered hemoglobin beta-chain synthesis amenable to allogeneic HSC transplantation and HSC gene therapy. Iron overload (IO) is a common complication in BT patients affecting several organs. However, data on the BM stromal compartment are scarce. METHODS. MSCs were isolated and characterized from BM aspirates of healthy donors (HDs) and BT patients. The state of IO was assessed and correlated with the presence of primitive MSCs in vitro and in vivo. Hematopoietic supportive capacity of MSCs was evaluated by transwell migration assay and 2D coculture of MSCs with human CD3[4.sup.+] HSCs. In vivo, the ability of MSCs to facilitate HSC engraftment was tested in a xenogenic transplant model, whereas the capacity to sustain human hematopoiesis was evaluated in humanized ossicle models. RESULTS. We report that, despite iron chelation, BT BM contains high levels of iron and ferritin, indicative of iron accumulation in the BM niche. We found a pauperization of the most primitive MSC pool caused by increased ROS production in vitro which impaired MSC stemness properties. We confirmed a reduced frequency of primitive MSCs in vivo in BT patients. We also discovered a weakened antioxidative response and diminished expression of BM niche-associated genes in BT-MSCs. This caused a functional impairment in MSC hematopoietic supportive capacity in vitro and in cotransplantation models. In addition, BT-MSCs failed to form a proper BM niche in humanized ossicle models. CONCLUSION. Our results suggest an impairment in the mesenchymal compartment of BT BM niche and highlight the need for novel strategies to target the niche to reduce IO and oxidative stress before transplantation. FUNDING. This work was supported by the SR-TIGET Core grant from Fondazione Telethon and by Ricerca Corrente., Introduction [beta]-Thalassemia (BT) is one of the most common inherited monogenic disorders in the world, with an overall carrier rate of 1.5% of the world population, and 60,000 BT symptomatic [...]

Published
2019
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19. Nanosphere’s Verigene® Blood Culture Assay to Detect Multidrug-Resistant Gram-Negative Bacterial Outbreak: A Prospective Study on 79 Hematological Patients in a Country with High Prevalence of Antimicrobial Resistance

Author

Greco, Raffaella, Barbanti, Maria Chiara, Mancini, Nicasio, Infurnari, Laura, Pasciuta, Renée, Forcina, Alessandra, Oltolini, Chiara, Casirati, Gabriele, Mannina, Daniele, Giglio, Fabio, Messina, Carlo, Morelli, Mara, Lorentino, Francesca, Mastaglio, Sara, Perini, Tommaso, Vago, Luca, Scarpellini, Paolo, Carrabba, Matteo Giovanni, Stanghellini, Maria Teresa Lupo, Marktel, Sarah, Assanelli, Andrea, Bernardi, Massimo, Corti, Consuelo, Peccatori, Jacopo, Clementi, Massimo, and Ciceri, Fabio

Published
2019
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20. Intrabone hematopoietic stem cell gene therapy for adult and pediatric patients affected by transfusion-dependent ß-thalassemia

Author

Marktel, Sarah, Scaramuzza, Samantha, Cicalese, Maria Pia, Giglio, Fabio, Galimberti, Stefania, Lidonnici, Maria Rosa, Calbi, Valeria, Assanelli, Andrea, Bernardo, Maria Ester, Rossi, Claudia, Calabria, Andrea, Milani, Raffaella, Gattillo, Salvatore, Benedicenti, Fabrizio, Spinozzi, Giulio, Aprile, Annamaria, Bergami, Alessandra, Casiraghi, Miriam, Consiglieri, Giulia, Masera, Nicoletta, D’Angelo, Emanuela, Mirra, Nadia, Origa, Raffaella, Tartaglione, Immacolata, Perrotta, Silverio, Winter, Robert, Coppola, Milena, Viarengo, Gianluca, Santoleri, Luca, Graziadei, Giovanna, Gabaldo, Michela, Valsecchi, Maria Grazia, Montini, Eugenio, Naldini, Luigi, Cappellini, Maria Domenica, Ciceri, Fabio, Aiuti, Alessandro, and Ferrari, Giuliana

Published
2019
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21. Intrabone transplant of a single unwashed umbilical cord blood unit with ATG-free and sirolimus-based GvHD prophylaxis: fast immune-reconstitution and long-term disease control in 30 patients with high-risk diseases

Author

Giglio, Fabio, primary, Xue, Elisabetta, additional, Barone, Angelica, additional, Lorentino, Francesca, additional, Greco, Raffaella, additional, Ruggeri, Annalisa, additional, Zambelli, Matilde, additional, Parisi, Cristina, additional, Milani, Raffaella, additional, Clerici, Daniela, additional, Piemontese, Simona, additional, Marktel, Sarah, additional, Lazzari, Lorenzo, additional, Marcatti, Magda, additional, Bernardi, Massimo, additional, Corti, Consuelo, additional, Lupo-Stanghellini, Maria Teresa, additional, Ciceri, Fabio, additional, and Peccatori, Jacopo, additional

Published
2023
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22. Posttransplantation Cyclophosphamide- and Sirolimus-Based Graft-Versus-Host-Disease Prophylaxis in Allogeneic Stem Cell Transplant

Author

Greco, Raffaella, Lorentino, Francesca, Albanese, Serena, Lupo Stanghellini, Maria Teresa, Giglio, Fabio, Piemontese, Simona, Clerici, Daniela, Lazzari, Lorenzo, Marcatti, Magda, Mastaglio, Sara, Xue, Elisabetta, Farina, Francesca, Pavesi, Francesca, Assanelli, Andrea, Carrabba, Matteo G., Marktel, Sarah, Vago, Luca, Bonini, Chiara, Corti, Consuelo, Bernardi, Massimo, Ciceri, Fabio, and Peccatori, Jacopo

Published
2021
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23. Human Herpesvirus 6 Infection Following Haploidentical Transplantation: Immune Recovery and Outcome

Author

Greco, Raffaella, Crucitti, Lara, Noviello, Maddalena, Racca, Sara, Mannina, Daniele, Forcina, Alessandra, Lorentino, Francesca, Valtolina, Veronica, Rolla, Serena, Dvir, Roee, Morelli, Mara, Giglio, Fabio, Barbanti, Maria Chiara, Lupo Stanghellini, Maria Teresa, Oltolini, Chiara, Vago, Luca, Scarpellini, Paolo, Assanelli, Andrea, Carrabba, Matteo G., Marktel, Sarah, Bernardi, Massimo, Corti, Consuelo, Clementi, Massimo, Peccatori, Jacopo, Bonini, Chiara, and Ciceri, Fabio

Published
2016
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24. Predicting failure of hematopoietic stem cell mobilization before it starts: the predicted poor mobilizer (pPM) score

Author

Olivieri, Jacopo, Attolico, Immacolata, Nuccorini, Roberta, Pascale, Sara Pasquina, Chiarucci, Martina, Poiani, Monica, Corradini, Paolo, Farina, Lucia, Gaidano, Gianluca, Nassi, Luca, Sica, Simona, Piccirillo, Nicola, Pioltelli, Pietro Enrico, Martino, Massimo, Moscato, Tiziana, Pini, Massimo, Zallio, Francesco, Ciceri, Fabio, Marktel, Sarah, Mengarelli, Andrea, Musto, Pellegrino, Capria, Saveria, Merli, Francesco, Codeluppi, Katia, Mele, Giuseppe, Lanza, Francesco, Specchia, Giorgina, Pastore, Domenico, Milone, Giuseppe, Saraceni, Francesco, Di Nardo, Elvira, Perseghin, Paolo, and Olivieri, Attilio

Published
2018
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25. Adjuvant role of SeptiFast to improve the diagnosis of sepsis in a large cohort of hematological patients

Author

Greco, Raffaella, Barbanti, Maria Chiara, Mancini, Nicasio, Crucitti, Lara, Oltolini, Chiara, Forcina, Alessandra, Lorentino, Francesca, Vago, Luca, Messina, Carlo, Clerici, Daniela, Morelli, Mara, Giglio, Fabio, Lupo Stanghellini, Maria Teresa, Infurnari, Laura, Carrabba, Matteo G., Marktel, Sarah, Assanelli, Andrea, Scarpellini, Paolo, Bernardi, Massimo, Peccatori, Jacopo, Corti, Consuelo, Clementi, Massimo, and Ciceri, Fabio

Published
2018
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28. Enteric Microbiome Markers as Early Predictors of Clinical Outcome in Allogeneic Hematopoietic Stem Cell Transplant: Results of a Prospective Study in Adult Patients

Author

Mancini, Nicasio, Greco, Raffaella, Pasciuta, Renée, Barbanti, Maria Chiara, Pini, Giacomo, Morrow, Olivia Beatrice, Morelli, Mara, Vago, Luca, Clementi, Nicola, Giglio, Fabio, Lupo Stanghellini, Maria Teresa, Forcina, Alessandra, Infurnari, Laura, Marktel, Sarah, Assanelli, Andrea, Carrabba, Matteo, Bernardi, Massimo, Corti, Consuelo, Burioni, Roberto, Peccatori, Jacopo, Sormani, Maria Pia, Banfi, Giuseppe, Ciceri, Fabio, and Clementi, Massimo

Published
2017
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29. Post-transplantation Cyclophosphamide and Sirolimus after Haploidentical Hematopoietic Stem Cell Transplantation Using a Treosulfan-based Myeloablative Conditioning and Peripheral Blood Stem Cells

Author

Cieri, Nicoletta, Greco, Raffaella, Crucitti, Lara, Morelli, Mara, Giglio, Fabio, Levati, Giorgia, Assanelli, Andrea, Carrabba, Matteo G., Bellio, Laura, Milani, Raffaella, Lorentino, Francesca, Stanghellini, Maria Teresa Lupo, De Freitas, Tiago, Marktel, Sarah, Bernardi, Massimo, Corti, Consuelo, Vago, Luca, Bonini, Chiara, Ciceri, Fabio, and Peccatori, Jacopo

Published
2015
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31. Patients Reported Outcomes (PROs) Are Still Unsatisfactory Among AML Long-Term Survivors: The Impact of Chronic GvHD in a Prospective Study on 15 Years Transplant Activity

Author

Lupo-Stanghellini, Maria Teresa, primary, Riva, Camilla, additional, Bruno, Alessandro, additional, Piemontese, Simona, additional, Greco, Raffaella, additional, Marktel, Sarah, additional, Mastaglio, Sara, additional, Xue, Elisabetta, additional, Clerici, Daniela, additional, Farina, Francesca, additional, Giglio, Fabio, additional, Diral, Elisa, additional, Vago, Luca, additional, Corti, Consuelo, additional, Assanelli, Andrea A., additional, Bernardi, Massimo, additional, Peccatori, Jacopo, additional, Carrabba, Matteo Giovanni, additional, and Ciceri, Fabio, additional

Published
2022
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32. Adaptive Routes of Hematopoietic Stem Cell Differentiation to Disease Conditions and Age in Gene Therapy Patients

Author

Calabria, Andrea, primary, Spinozzi, Giulio, additional, Cesana, Daniela, additional, Benedicenti, Fabrizio, additional, Pais, Giulia, additional, Scala, Serena, additional, Lidonnici, Maria Rosa, additional, Scaramuzza, Samantha, additional, Albertini, Alessandra, additional, Esposito, Simona, additional, De Mattia, Fabiola, additional, Canarutto, Daniele, additional, Tucci, Francesca, additional, Omrani, Maryam, additional, Dionisio, Francesca, additional, Giannelli, Stefania, additional, Marktel, Sarah, additional, Calbi, Valeria, additional, Ferrua, Francesca, additional, Gentner, Bernhard, additional, Ciceri, Fabio, additional, Naldini, Luigi, additional, Ferrari, Giuliana, additional, Aiuti, Alessandro, additional, and Montini, Eugenio, additional

Published
2022
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33. Case Report: Consistent disease manifestations with a staggered time course in two identical twins affected by adenosine deaminase 2 deficiency

Author

Barzaghi, Federica, primary, Cicalese, Maria Pia, additional, Zoccolillo, Matteo, additional, Brigida, Immacolata, additional, Barcella, Matteo, additional, Merelli, Ivan, additional, Sartirana, Claudia, additional, Zanussi, Monica, additional, Calbi, Valeria, additional, Bernardo, Maria Ester, additional, Tucci, Francesca, additional, Migliavacca, Maddalena, additional, Giglio, Fabio, additional, Doglio, Matteo, additional, Canarutto, Daniele, additional, Ferrua, Francesca, additional, Consiglieri, Giulia, additional, Prunotto, Giulia, additional, Saettini, Francesco, additional, Bonanomi, Sonia, additional, Rovere-Querini, Patrizia, additional, Di Colo, Giulia, additional, Jofra, Tatiana, additional, Fousteri, Georgia, additional, Penco, Federica, additional, Gattorno, Marco, additional, Hershfield, Michael S., additional, Bongiovanni, Lucia, additional, Ponzoni, Maurilio, additional, Marktel, Sarah, additional, Milani, Raffaella, additional, Peccatori, Jacopo, additional, Ciceri, Fabio, additional, Mortellaro, Alessandra, additional, and Aiuti, Alessandro, additional

Published
2022
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34. Minimal residual disease detection by next-generation sequencing in multiple myeloma: Promise and challenges for response-adapted therapy

Author

Ferla, Valeria, primary, Antonini, Elena, additional, Perini, Tommaso, additional, Farina, Francesca, additional, Masottini, Serena, additional, Malato, Simona, additional, Marktel, Sarah, additional, Lupo Stanghellini, Maria Teresa, additional, Tresoldi, Cristina, additional, Ciceri, Fabio, additional, and Marcatti, Magda, additional

Published
2022
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35. Minnesota acute graft-versus-host disease risk score predicts survival at onset of graft-versus-host disease after post-transplant cyclophosphamide prophylaxis

Author

Ardizzoia, Federica, primary, Lorentino, Francesca, additional, Bruno, Alessandro, additional, Marktel, Sarah, additional, Giglio, Fabio, additional, Clerici, Daniela, additional, Farina, Francesca, additional, Mastaglio, Sara, additional, Piemontese, Simona, additional, Assanelli, Andrea A., additional, Carrabba, Matteo G., additional, Bernardi, Massimo, additional, Corti, Consuelo, additional, Peccatori, Jacopo, additional, Ciceri, Fabio, additional, Greco, Raffaella, additional, and Lupo-Stanghellini, Maria Teresa, additional

Published
2022
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36. Very Low Rate of Readmission after an Early Discharge Outpatient Model for Autografting in Multiple Myeloma Patients: An Italian Multicenter Retrospective Study

Author

Martino, Massimo, Montanari, Mauro, Ferrara, Felicetto, Ciceri, Fabio, Scortechini, Ilaria, Palmieri, Salvatore, Marktel, Sarah, Cimminiello, Michele, Messina, Giuseppe, Irrera, Giuseppe, Offidani, Massimo, Console, Giuseppe, Castagna, Luca, Milone, Giuseppe, Bruno, Benedetto, Tripepi, Giovanni, Lemoli, Roberto Massimo, and Olivieri, Attilio

Published
2014
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37. Inhibition of FGF23 is a therapeutic strategy to target hematopoietic stem cell niche defects in β-thalassemia.

Author

Aprile, Annamaria, Raggi, Laura, Bolamperti, Simona, Villa, Isabella, Storto, Mariangela, Morello, Gaia, Marktel, Sarah, Tripodo, Claudio, Cappellini, Maria Domenica, Motta, Irene, Rubinacci, Alessandro, and Ferrari, Giuliana

Subjects
HEMATOPOIETIC stem cells, STEM cell niches, FIBROBLAST growth factors, ERYTHROPOIETIN receptors, FETAL hemoglobin, BONE cells, PEPTIDES, BONE marrow
Abstract

Clinical evidence highlights a relationship between the blood and the bone, but the underlying mechanism linking these two tissues is not fully elucidated. Here, we used β-thalassemia as a model of congenital anemia with bone and bone marrow (BM) niche defects. We demonstrate that fibroblast growth factor 23 (FGF23) is increased in patients and mice with β-thalassemia because erythropoietin induces FGF23 overproduction in bone and BM erythroid cells via ERK1/2 and STAT5 pathways. We show that in vivo inhibition of FGF23 signaling by carboxyl-terminal FGF23 peptide is a safe and efficacious therapeutic strategy to rescue bone mineralization and deposition in mice with β-thalassemia, normalizing the expression of niche factors and restoring hematopoietic stem cell (HSC) function. FGF23 may thus represent a molecular link connecting anemia, bone, and the HSC niche. This study provides a translational approach to targeting bone defects and rescuing HSC niche interactions, with potential clinical relevance for improving HSC transplantation and gene therapy for hematopoietic disorders. Editor's summary: Why β-thalassemia results in bone defects in some patients is unclear. Aprile et al. show that the elevated erythropoietin seen in β-thalassemia results in increased fibroblast growth factor 23 (FGF23) in the bone and bone marrow, which can produce bone defects. A small peptide inhibiting FGF23 both restored the bone marrow hematopoietic stem cell niche and rescued bone defects in a mouse model. This study thus ties the blood and bone together in β-thalassemia and demonstrates an avenue to target their pathological interaction. —Catherine A. Charneski [ABSTRACT FROM AUTHOR]

Published
2023
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38. Defibrotide Prophylaxis of Sinusoidal Obstruction Syndrome in Adults Treated With Inotuzumab Ozogamicin Prior to Hematopoietic Stem Cell Transplantation

Author

Giglio, Fabio, primary, Xue, Elisabetta, additional, Greco, Raffaella, additional, Lazzari, Lorenzo, additional, Clerici, Daniela Teresa, additional, Lorentino, Francesca, additional, Mastaglio, Sara, additional, Marktel, Sarah, additional, Lupo-Stanghellini, Maria Teresa, additional, Marcatti, Magda, additional, Corti, Consuelo, additional, Bernardi, Massimo, additional, Piemontese, Simona, additional, Ciceri, Fabio, additional, and Peccatori, Jacopo, additional

Published
2022
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39. Follicular helper T cell signature of replicative exhaustion, apoptosis, and senescence in common variable immunodeficiency

Author

Milardi, Giulia, primary, Di Lorenzo, Biagio, additional, Gerosa, Jolanda, additional, Barzaghi, Federica, additional, Di Matteo, Gigliola, additional, Omrani, Maryam, additional, Jofra, Tatiana, additional, Merelli, Ivan, additional, Barcella, Matteo, additional, Filippini, Matteo, additional, Conti, Anastasia, additional, Ferrua, Francesca, additional, Pozzo Giuffrida, Francesco, additional, Dionisio, Francesca, additional, Rovere‐Querini, Patrizia, additional, Marktel, Sarah, additional, Assanelli, Andrea, additional, Piemontese, Simona, additional, Brigida, Immacolata, additional, Zoccolillo, Matteo, additional, Cirillo, Emilia, additional, Giardino, Giuliana, additional, Danieli, Maria Giovanna, additional, Specchia, Fernando, additional, Pacillo, Lucia, additional, Di Cesare, Silvia, additional, Giancotta, Carmela, additional, Romano, Francesca, additional, Matarese, Alessandro, additional, Chetta, Alfredo Antonio, additional, Trimarchi, Matteo, additional, Laurenzi, Andrea, additional, De Pellegrin, Maurizio, additional, Darin, Silvia, additional, Montin, Davide, additional, Marinoni, Maddalena, additional, Dellepiane, Rosa Maria, additional, Sordi, Valeria, additional, Lougaris, Vassilios, additional, Vacca, Angelo, additional, Melzi, Raffaella, additional, Nano, Rita, additional, Azzari, Chiara, additional, Bongiovanni, Lucia, additional, Pignata, Claudio, additional, Cancrini, Caterina, additional, Plebani, Alessandro, additional, Piemonti, Lorenzo, additional, Petrovas, Constantinos, additional, Di Micco, Raffaella, additional, Ponzoni, Maurilio, additional, Aiuti, Alessandro, additional, Cicalese, Maria Pia, additional, and Fousteri, Georgia, additional

Published
2022
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40. Letermovir reduces chronic GVHD risk in calcineurin inhibitor-free GVHD prophylaxis after hematopoietic cell transplantation

Author

Lorentino, Francesca, primary, Xue, Elisabetta, additional, Mastaglio, Sara, additional, Giglio, Fabio, additional, Clerici, Daniela, additional, Farina, Francesca, additional, Piemontese, Simona, additional, Bruno, Alessandro, additional, Lazzari, Lorenzo, additional, Ruggeri, Annalisa, additional, Guggiari, Elena, additional, Lunghi, Francesca, additional, Assanelli, Andrea A., additional, Marktel, Sarah, additional, Marcatti, Magda, additional, Carrabba, Matteo G., additional, Bernardi, Massimo, additional, Corti, Consuelo, additional, Peccatori, Jacopo, additional, Ciceri, Fabio, additional, Greco, Raffaella, additional, and Lupo-Stanghellini, Maria Teresa, additional

Published
2022
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41. sj-docx-1-tah-10.1177_20406207221090882 – Supplemental material for Azacitidine and donor lymphocytes infusions in acute myeloid leukemia and myelodysplastic syndrome relapsed after allogeneic hematopoietic stem cell transplantation from alternative donors

Author

Liberatore, Carmine, Stanghellini, Maria Teresa Lupo, Lorentino, Francesca, Vago, Luca, Carrabba, Matteo Giovanni, Greco, Raffaella, Marktel, Sarah, Assanelli, Andrea, Farina, Francesca, Corti, Consuelo, Bernardi, Massimo, Peccatori, Jacopo, Sockel, Katja, Middeke, Jan Moritz, Schetelig, Johannes, Bergmann, Anika, Rautenberg, Christina, Ciceri, Fabio, Bornhäuser, Martin, Schroeder, Thomas, and Stölzel, Friedrich

Subjects
FOS: Clinical medicine, Cardiology, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-docx-1-tah-10.1177_20406207221090882 for Azacitidine and donor lymphocytes infusions in acute myeloid leukemia and myelodysplastic syndrome relapsed after allogeneic hematopoietic stem cell transplantation from alternative donors by Carmine Liberatore, Maria Teresa Lupo Stanghellini, Francesca Lorentino, Luca Vago, Matteo Giovanni Carrabba, Raffaella Greco, Sarah Marktel, Andrea Assanelli, Francesca Farina, Consuelo Corti, Massimo Bernardi, Jacopo Peccatori, Katja Sockel, Jan Moritz Middeke, Johannes Schetelig, Anika Bergmann, Christina Rautenberg, Fabio Ciceri, Martin Bornhäuser, Thomas Schroeder and Friedrich Stölzel in Therapeutic Advances in Hematology

Published
2022
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42. Risk of complications during hematopoietic stem cell collection in pediatric sibling donors: a prospective European Group for Blood and Marrow Transplantation Pediatric Diseases Working Party study

Author

Styczynski, Jan, Balduzzi, Adriana, Gil, Lidia, Labopin, Myriam, Hamladji, Rose-Marie, Marktel, Sarah, Yesilipek, M. Akif, Fagioli, Franca, Ehlert, Karoline, Matulova, Martina, Dalle, Jean-Hugues, Wachowiak, Jacek, Miano, Maurizio, Messina, Chiara, Diaz, Miguel Angel, Vermylen, Christiane, Eyrich, Matthias, Badell, Isabel, Dreger, Peter, Gozdzik, Jolanta, Hutt, Daphna, Rascon, Jelena, Dini, Giorgio, and Peters, Christina

Published
2012
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43. Transfusional Approach in Multi-Ethnic Sickle Cell Patients: Real-World Practice Data From a Multicenter Survey in Italy

Author

Graziadei, Giovanna, primary, De Franceschi, Lucia, additional, Sainati, Laura, additional, Venturelli, Donatella, additional, Masera, Nicoletta, additional, Bonomo, Piero, additional, Vassanelli, Aurora, additional, Casale, Maddalena, additional, Lodi, Gianluca, additional, Voi, Vincenzo, additional, Rigano, Paolo, additional, Pinto, Valeria Maria, additional, Quota, Alessandra, additional, Notarangelo, Lucia D., additional, Russo, Giovanna, additional, Allò, Massimo, additional, Rosso, Rosamaria, additional, D'Ascola, Domenico, additional, Facchini, Elena, additional, Macchi, Silvia, additional, Arcioni, Francesco, additional, Bonetti, Federico, additional, Rossi, Enza, additional, Sau, Antonella, additional, Campisi, Saveria, additional, Colarusso, Gloria, additional, Giona, Fiorina, additional, Lisi, Roberto, additional, Giordano, Paola, additional, Boscarol, Gianluca, additional, Filosa, Aldo, additional, Marktel, Sarah, additional, Maroni, Paola, additional, Murgia, Mauro, additional, Origa, Raffaella, additional, Longo, Filomena, additional, Bortolotti, Marta, additional, Colombatti, Raffaella, additional, Di Maggio, Rosario, additional, Mariani, Raffaella, additional, Piperno, Alberto, additional, Corti, Paola, additional, Fidone, Carmelo, additional, Palazzi, Giovanni, additional, Badalamenti, Luca, additional, Gianesin, Barbara, additional, Piel, Frédéric B., additional, and Forni, Gian Luca, additional

Published
2022
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44. Azacitidine and donor lymphocytes infusions in acute myeloid leukemia and myelodysplastic syndrome relapsed after allogeneic hematopoietic stem cell transplantation from alternative donors

Author

Liberatore, Carmine, primary, Stanghellini, Maria Teresa Lupo, additional, Lorentino, Francesca, additional, Vago, Luca, additional, Carrabba, Matteo Giovanni, additional, Greco, Raffaella, additional, Marktel, Sarah, additional, Assanelli, Andrea, additional, Farina, Francesca, additional, Corti, Consuelo, additional, Bernardi, Massimo, additional, Peccatori, Jacopo, additional, Sockel, Katja, additional, Middeke, Jan Moritz, additional, Schetelig, Johannes, additional, Bergmann, Anika, additional, Rautenberg, Christina, additional, Ciceri, Fabio, additional, Bornhäuser, Martin, additional, Schroeder, Thomas, additional, and Stölzel, Friedrich, additional

Published
2022
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46. Graft-versus-lymphoma effect inside the central nervous system in a patient with extranodal natural killer/T-cell lymphoma, nasal type

Author

Lazzari, Lorenzo, Farina, Francesca, Lupo Stanghellini, Maria Teresa, Piemontese, Simona, Marktel, Sarah, Mazzi, Benedetta, Vago, Luca, Milani, Raffaella, Ferrario, Andrea, Bianchi, Benedetta, Merli, Michele, Ferreri, Andrés José María, Corti, Consuelo, Peccatori, Jacopo, Ruggeri, Annalisa, and Ciceri, Fabio

Published
2021
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47. Inhibition of Fibroblast Growth Factor-23 (FGF-23) Rescues Bone and Hematopoietic Stem Cell Niche Defects in Beta-Thalassemia, Uncovering the Missing Link between Hematopoiesis and Bone

Author

Aprile, Annamaria, primary, Raggi, Laura, additional, Bolamperti, Simona, additional, Storto, Mariangela, additional, Villa, Isabella, additional, Morello, Gaia, additional, Marktel, Sarah, additional, Tripodo, Claudio, additional, Motta, Irene, additional, Cappellini, Maria Domenica, additional, Rubinacci, Alessandro, additional, and Ferrari, Giuliana, additional

Published
2021
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48. Second Solid Cancers After Hematopoietic Stem Cell Transplantation: Active Surveillance During Long-term Follow-up

Author

Lupo-Stanghellini, Maria Teresa, primary, Piemontese, Simona, additional, Assanelli, Andrea, additional, Serpenti, Fabio, additional, Mastaglio, Sara, additional, Clerici, Daniela, additional, Giglio, Fabio, additional, Greco, Raffaella, additional, Lorentino, Francesca, additional, Pavesi, Francesca, additional, Farina, Francesca, additional, Marktel, Sarah, additional, Corti, Consuelo, additional, Peccatori, Jacopo, additional, and Ciceri, Fabio, additional

Published
2021
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