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O presente estudo avaliou a ocorrência da infecção pelo HTLV-1 e seus subtipos em amostras de sangue de pacientes com diagnóstico clínico de paraparesia espástica tropical/mielopatia associada ao Htlv-1. A detecção da infecção pelo HTLV realizou-se através de testes sorológico e molecular. Cinco amostras estavam infectadas pelo HTLV-1 do subtipo Cosmopolita, subgrupo Transcontinental. Os resultados obtidos confirmam a ocorrência de infecção pelo HTLV-1 em pacientes com diagnóstico clínico de paraparesia espástica tropical/mielopatia associada ao Htlv-1em Belém, Pará.The present study evaluated the occurrence of HTLV-1 and its subtypes in blood samples of patients presenting symptoms of tropical spastic paraparesis/HTLV-1 associated myelopathy. The detection of HTLV infection was performed by serological and molecular assays. Five patients were infected by HTLV-1 of the Cosmopolitan subtype, subgroup Transcontinental. The results confirm the occurrence of HTLV-1 infection among patients with clinical diagnosis of tropical spastic paraparesis/HTLV-1 associated myelopathy in Belém, Pará.

AbstractThe molecular epidemiology of HIV-1 strains circulating in Belem-PA and Macapa-AP, in the Northern region of Brazil, is described using sequences of the C2V3 segment of the envand the progene of HIV-1 from patients of the Reference Unit for Special Infectious and Parasitary Diseases (URE-DIPE) in Belem-PA and the Central Laboratory (LACEN) in Macapa-AP. Subtype B was the most frequently found in relation to pro(88.3%) in Belem and in Macapa (97.1%) and env(88.3% in Belem and 100% in Macapa). Subtype F was also described in Belem (9.3% proand 8.3% env) and Macapa (2.8% pro). Subtype D was described for the first time in the Northern region of the country as well as the recent entry of CRF02_AG. Furthermore, several possible recombinant forms among the various subtypes were found in both cities. The results support the hypothesis that HIV-1 infection is associated with the epidemic of the virus in the Southeast region of the country and that the city of Belem is the most important route for HIV-1 entry in the Northern region of Brazil. [ABSTRACT FROM AUTHOR]