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1. Genomic events stratifying prognosis of early gastric cancer

Author

Molinari, Chiara, Solaini, Leonardo, Rebuzzi, Francesca, Tedaldi, Gianluca, Angeli, Davide, Petracci, Elisabetta, Prascevic, Dusan, Ewald, Jan, Rahm, Erhard, Canale, Matteo, Giovanni, Martinelli, Tomezzoli, Anna, Bencivenga, Maria, Ambrosio, Maria Raffaella, Marrelli, Daniele, Morgagni, Paolo, Ercolani, Giorgio, Ulivi, Paola, and Saragoni, Luca

Published
2024
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3. International consensus on the management of metastatic gastric cancer: step by step in the foggy landscape: Bertinoro Workshop, November 2022

Author

Morgagni, Paolo, Bencivenga, Maria, Carneiro, Fatima, Cascinu, Stefano, Derks, Sarah, Di Bartolomeo, Maria, Donohoe, Claire, Eveno, Clarisse, Gisbertz, Suzanne, Grimminger, Peter, Gockel, Ines, Grabsch, Heike, Kassab, Paulo, Langer, Rupert, Lonardi, Sara, Maltoni, Marco, Markar, Sheraz, Moehler, Markus, Marrelli, Daniele, Mazzei, Maria Antonietta, Melisi, Davide, Milandri, Carlo, Moenig, Paul Stefan, Mostert, Bianca, Mura, Gianni, Polkowski, Wojciech, Reynolds, John, Saragoni, Luca, Van Berge Henegouwen, Mark I., Van Hillegersberg, Richard, Vieth, Michael, Verlato, Giuseppe, Torroni, Lorena, Wijnhoven, Bas, Tiberio, Guido Alberto Massimo, Yang, Han-Kwang, Roviello, Franco, and de Manzoni, Giovanni

Published
2024
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4. Correction: International consensus on the management of metastatic gastric cancer: step by step in the foggy landscape

Author

Morgagni, Paolo, Bencivenga, Maria, Carneiro, Fatima, Cascinu, Stefano, Derks, Sarah, Di Bartolomeo, Maria, Donohoe, Claire, Eveno, Clarisse, Gisbertz, Suzanne, Grimminger, Peter, Gockel, Ines, Grabsch, Heike, Kassab, Paulo, Langer, Rupert, Lonardi, Sara, Maltoni, Marco, Markar, Sheraz, Moehler, Markus, Marrelli, Daniele, Mazzei, Maria Antonietta, Melisi, Davide, Milandri, Carlo, Moenig, Paul Stefan, Mostert, Bianca, Mura, Gianni, Polkowski, Wojciech, Reynolds, John, Saragoni, Luca, Van Berge Henegouwen, Mark I., Van Hillegersberg, Richard, Vieth, Michael, Verlato, Giuseppe, Torroni, Lorena, Wijnhoven, Bas, Tiberio, Guido Alberto Massimo, Yang, Han-Kwang, Roviello, Franco, and de Manzoni, Giovanni

Published
2024
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5. Enhanced recovery after surgery (ERAS) implementation in cytoreductive surgery (CRS) and hyperthermic IntraPEritoneal chemotherapy (HIPEC): Insights from Italian peritoneal surface malignancies expert centers

Author

Robella, Manuela, Vaira, Marco, Ansaloni, Luca, Asero, Salvatore, Bacchetti, Stefano, Borghi, Felice, Casella, Francesco, Coccolini, Federico, De Cian, Franco, di Giorgio, Andrea, Framarini, Massimo, Gelmini, Roberta, Graziosi, Luigina, Kusamura, Shigeki, Lippolis, Piero, Lo Dico, Rea, Macrì, Antonio, Marrelli, Daniele, Sammartino, Paolo, Sassaroli, Cinzia, Scaringi, Stefano, Tonello, Marco, Valle, Mario, and Sommariva, Antonio

Published
2024
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7. A national survey on the current status of minimally invasive gastric practice on behalf of GIRCG

Author

Milone, Marco, D’Amore, Anna, Alfieri, Sergio, Ambrosio, Maria Raffaella, Andreuccetti, Jacopo, Ansaloni, Luca, Antonucci, Adelmo, Arganini, Marco, Baiocchi, Gianluca, Barone, Mirko, Bencini, Lapo, Bencivenga, Maria, Boccia, Luigi, Boni, Luigi, Braga, Marco, Cianchi, Fabio, Cipollari, Chiara, Contine, Alessandro, Cotsoglou, Christian, D’Imporzano, Simone, De Manzoni, Giovanni, De Pascale, Stefano, De Ruvo, Nicola, Degiuli, Maurizio, Donini, Annibale, Elmore, Ugo, Ercolani, Giorgio, Ferrari, Giovanni, Fumagalli, Romario Uberto, Garulli, Gianluca, Gelmini, Roberta, Graziosi, Luigina, Gualtierotti, Monica, Guglielmi, Alfredo, Inama, Marco, Maffeis, Federica, Maione, Francesco, Manigrasso, Michele, Marchesi, Federico, Marrelli, Daniele, Massobrio, Andrea, Moretto, Gianluigi, Moukachar, Aballah, Navarra, Giuseppe, Nigri, Giuseppe, Olmi, Stefano, Palaia, Raffaele, Papis, Davide, Parise, Paolo, Pedrazzani, Corrado, Petri, Roberto, Pignata, Giusto, Pisano, Michele, Rausei, Stefano, Reddavid, Rossella, Rocco, Giuseppe, Rosa, Fausto, Rosati, Riccardo, Rossit, Luca, Rottoli, Matteo, Roviello, Franco, Santi, Stefano, Scabini, Stefano, Scaringi, Stefano, Solaini, Leonardo, Staderini, Fabio, Taglietti, Lucio, Torre, Beatrice, Ubiali, Paolo, Uccelli, Matteo, Uggeri, Fabio, Vertaldi, Sara, Viganò, Jacopo, De Palma, Giovanni Domenico, and Giacopuzzi, Simone

Published
2023
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8. A pragmatic approach improves the clinical management of stage IV gastric cancer: Comparison between the Meta-Gastro results and the GIRCG's retrospective series

Author

Arizzi, Valeria, Bloise, Francesco, Cocozza, Eugenio, Desio, Matteo, Marchionini, Valentina, Ascari, Filippo, Donini, Annibale, De Giuli, Maurizio, Potenza, Enrico, Pittiani, Frida, Frittoli, Barbara, Funicelli, Luigi, Cella, Chiara Alessandra, Ministrini, Silvia, Bencivenga, Maria, Filippini, Federica, Mura, Gianni, Milandri, Carlo, Mazzei, Maria Antonietta, Bagnacci, Giulio, Berselli, Mattia, Monti, Manlio, Morgagni, Paolo, Solaini, Leonardo, Marrelli, Daniele, Piccioni, Stefania, De Pascale, Stefano, Graziosi, Luigina, Reddavid, Rossella, Rosa, Fausto, Belluco, Claudio, and Tiberio, Guido

Published
2024
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11. Clinical outcomes of patients with complicated post-operative course after gastrectomy for cancer: a GIRCG study using the GASTRODATA registry

Author

Baiocchi, Gian Luca, Giacopuzzi, Simone, Vittimberga, Giovanni, De Pascale, Stefano, Pastorelli, Elisabetta, Gelmini, Roberta, Viganò, Jacopo, Graziosi, Luigina, Vagliasindi, Alessio, Rosa, Fausto, Steccanella, Francesca, Demartini, Paolo, Reddavid, Rossella, Berselli, Mattia, Elmore, Ugo, Romario, Uberto Fumagalli, Degiuli, Maurizio, Morgagni, Paolo, Marrelli, Daniele, D’Ugo, Domenico, Rosati, Riccardo, and De Manzoni, Giovanni

Published
2023
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14. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) in multimodal therapy for patients with oligometastatic peritoneal gastric cancer: a randomized multicenter phase III trial PIPAC VEROne

Author

Casella Francesco, Bencivenga Maria, Rosati Riccardo, Fumagalli Uberto Romario, Marrelli Daniele, Pacelli Fabio, Macrì Antonio, Donini Annibale, Torroni Lorena, Pavarana Michele, and De Manzoni Giovanni

Subjects
gastric cancer, intraperitoneal chemotherapy, peritoneal metastases, pipac, systemic chemotherapy, Medicine, Specialties of internal medicine, RC581-951
Abstract

Peritoneal carcinomatosis is the most frequent site of metastases in patients with gastric cancer. Current standard treatment is palliative systemic chemotherapy with very poor prognosis. Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) resulted in long-term benefits in selected patients. Among patients with peritoneal carcinomatosis, a distinctive subset is oligometastatic disease which is characterized by low metastatic burden. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a recent technique of intraperitoneal chemotherapy used in combination with systemic chemotherapy with promising results.

Published
2022
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23. Non-specific Abdominal Pain

Author

Brachet-Contul, Riccardo, Cinti, Lorenzo, Nardi, Mario Junior, Condurro, Salvatore, Millo, Paolo, Marrelli, Daniele, Agresta, Ferdinando, editor, Podda, Mauro, editor, Campanile, Fabio Cesare, editor, Bergamini, Carlo, editor, and Anania, Gabriele, editor

Published
2021
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24. Structured and shared CT radiological report of gastric cancer: a consensus proposal by the Italian Research Group for Gastric Cancer (GIRCG) and the Italian Society of Medical and Interventional Radiology (SIRM)

Author

Mazzei, Maria Antonietta, Bagnacci, Giulio, Gentili, Francesco, Capitoni, Iacopo, Mura, Gianni, Marrelli, Daniele, Petrioli, Roberto, Brunese, Luca, Cappabianca, Salvatore, Catarci, Marco, Degiuli, Maurizio, De Manzoni, Giovanni, De Prizio, Marco, Donini, Annibale, Romario, Uberto Fumagalli, Funicelli, Luigi, Laghi, Andrea, Minetti, Giuseppe, Morgagni, Paolo, Petrella, Enrico, Pittiani, Frida, Rausei, Stefano, Romanini, Laura, Rosati, Riccardo, Ianora, Amato Antonio Stabile, Tiberio, Guido A. M., Volterrani, Luca, Roviello, Franco, and Grassi, Roberto

Published
2022
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25. Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Gastric Cancer with Synchronous Peritoneal Metastases: Multicenter Study of ‘Italian Peritoneal Surface Malignancies Oncoteam—S.I.C.O.’

Author

Marano, Luigi, Marrelli, Daniele, Sammartino, Paolo, Biacchi, Daniele, Graziosi, Luigina, Marino, Elisabetta, Coccolini, Federico, Fugazzola, Paola, Valle, Mario, Federici, Orietta, Baratti, Dario, Deraco, Marcello, Di Giorgio, Andrea, Macrì, Antonio, Pasqual, Enrico Maria, Framarini, Massimo, Vaira, Marco, and Roviello, Franco

Published
2021
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27. Posterior and Para-Aortic (D2plus) Lymphadenectomy after Neoadjuvant/Conversion Therapy for Locally Advanced/Oligometastatic Gastric Cancer

Author

Marrelli, Daniele, primary, Piccioni, Stefania Angela, additional, Carbone, Ludovico, additional, Petrioli, Roberto, additional, Costantini, Maurizio, additional, Malagnino, Valeria, additional, Bagnacci, Giulio, additional, Rizzoli, Gabriele, additional, Calomino, Natale, additional, Piagnerelli, Riccardo, additional, Mazzei, Maria Antonietta, additional, and Roviello, Franco, additional

Published
2024
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32. Correction: International consensus on the management of metastatic gastric cancer: step by step in the foggy landscape (Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2024) 27 4 DOI: 10.1007/s10120-024-01479-5)

Author

MS CGO, Cancer, Morgagni, Paolo, Bencivenga, Maria, Carneiro, Fatima, Cascinu, Stefano, Derks, Sarah, Di Bartolomeo, Maria, Donohoe, Claire, Eveno, Clarisse, Gisbertz, Suzanne, Grimminger, Peter, Gockel, Ines, Grabsch, Heike, Kassab, Paulo, Langer, Rupert, Lonardi, Sara, Maltoni, Marco, Markar, Sheraz, Moehler, Markus, Marrelli, Daniele, Mazzei, Maria Antonietta, Melisi, Davide, Milandri, Carlo, Moenig, Paul Stefan, Mostert, Bianca, Mura, Gianni, Polkowski, Wojciech, Reynolds, John, Saragoni, Luca, Van Berge Henegouwen, Mark I., Van Hillegersberg, Richard, Vieth, Michael, Verlato, Giuseppe, Torroni, Lorena, Wijnhoven, Bas, Tiberio, Guido Alberto Massimo, Yang, Han Kwang, Roviello, Franco, de Manzoni, Giovanni, Bertinoro Workshop Working Group, MS CGO, Cancer, Morgagni, Paolo, Bencivenga, Maria, Carneiro, Fatima, Cascinu, Stefano, Derks, Sarah, Di Bartolomeo, Maria, Donohoe, Claire, Eveno, Clarisse, Gisbertz, Suzanne, Grimminger, Peter, Gockel, Ines, Grabsch, Heike, Kassab, Paulo, Langer, Rupert, Lonardi, Sara, Maltoni, Marco, Markar, Sheraz, Moehler, Markus, Marrelli, Daniele, Mazzei, Maria Antonietta, Melisi, Davide, Milandri, Carlo, Moenig, Paul Stefan, Mostert, Bianca, Mura, Gianni, Polkowski, Wojciech, Reynolds, John, Saragoni, Luca, Van Berge Henegouwen, Mark I., Van Hillegersberg, Richard, Vieth, Michael, Verlato, Giuseppe, Torroni, Lorena, Wijnhoven, Bas, Tiberio, Guido Alberto Massimo, Yang, Han Kwang, Roviello, Franco, de Manzoni, Giovanni, and Bertinoro Workshop Working Group

Published
2024

33. International consensus on the management of metastatic gastric cancer:step by step in the foggy landscape

Author

Morgagni, Paolo, Bencivenga, Maria, Carneiro, Fatima, Cascinu, Stefano, Derks, Sarah, Di Bartolomeo, Maria, Donohoe, Claire, Eveno, Clarisse, Gisbertz, Suzanne, Grimminger, Peter, Gockel, Ines, Grabsch, Heike, Kassab, Paulo, Langer, Rupert, Lonardi, Sara, Maltoni, Marco, Markar, Sheraz, Moehler, Markus, Marrelli, Daniele, Mazzei, Maria Antonietta, Melisi, Davide, Milandri, Carlo, Moenig, Paul Stefan, Mostert, Bianca, Mura, Gianni, Polkowski, Wojciech, Reynolds, John, Saragoni, Luca, Van Berge Henegouwen, Mark I., Van Hillegersberg, Richard, Vieth, Michael, Verlato, Giuseppe, Torroni, Lorena, Wijnhoven, Bas, Tiberio, Guido Alberto Massimo, Yang, Han Kwang, Roviello, Franco, de Manzoni, Giovanni, Morgagni, Paolo, Bencivenga, Maria, Carneiro, Fatima, Cascinu, Stefano, Derks, Sarah, Di Bartolomeo, Maria, Donohoe, Claire, Eveno, Clarisse, Gisbertz, Suzanne, Grimminger, Peter, Gockel, Ines, Grabsch, Heike, Kassab, Paulo, Langer, Rupert, Lonardi, Sara, Maltoni, Marco, Markar, Sheraz, Moehler, Markus, Marrelli, Daniele, Mazzei, Maria Antonietta, Melisi, Davide, Milandri, Carlo, Moenig, Paul Stefan, Mostert, Bianca, Mura, Gianni, Polkowski, Wojciech, Reynolds, John, Saragoni, Luca, Van Berge Henegouwen, Mark I., Van Hillegersberg, Richard, Vieth, Michael, Verlato, Giuseppe, Torroni, Lorena, Wijnhoven, Bas, Tiberio, Guido Alberto Massimo, Yang, Han Kwang, Roviello, Franco, and de Manzoni, Giovanni

Abstract

Background: Many gastric cancer patients in Western countries are diagnosed as metastatic with a median overall survival of less than twelve months using standard chemotherapy. Innovative treatments, like targeted therapy or immunotherapy, have recently proved to ameliorate prognosis, but a general agreement on managing oligometastatic disease has yet to be achieved. An international multi-disciplinary workshop was held in Bertinoro, Italy, in November 2022 to verify whether achieving a consensus on at least some topics was possible. Methods: A two-round Delphi process was carried out, where participants were asked to answer 32 multiple-choice questions about CT, laparoscopic staging and biomarkers, systemic treatment for different localization, role and indication of palliative care. Consensus was established with at least a 67% agreement. Results: The assembly agreed to define oligometastases as a “dynamic” disease which either regresses or remains stable in response to systemic treatment. In addition, the definition of oligometastases was restricted to the following sites: para-aortic nodal stations, liver, lung, and peritoneum, excluding bones. In detail, the following conditions should be considered as oligometastases: involvement of para-aortic stations, in particular 16a2 or 16b1; up to three technically resectable liver metastases; three unilateral or two bilateral lung metastases; peritoneal carcinomatosis with PCI ≤ 6. No consensus was achieved on how to classify positive cytology, which was considered as oligometastatic by 55% of participants only if converted to negative after chemotherapy. Conclusion: As assessed at the time of diagnosis, surgical treatment of oligometastases should aim at R0 curativity on the entire disease volume, including both the primary tumor and its metastases. Conversion surgery was defined as surgery on the residual volume of disease, which was initially not resectable for technical and/or oncological reasons but nevertheles

Published
2024

34. A pragmatic approach improves the clinical management of stage IV gastric cancer: Comparison between the Meta-Gastro results and the GIRCG's retrospective series

Author

Ministrini, Silvia, Bencivenga, Maria, Filippini, Federica, Mura, Gianni, Milandri, Carlo, Mazzei, Maria Antonietta, Bagnacci, Giulio, Berselli, Mattia, Monti, Manlio, Morgagni, Paolo, Solaini, Leonardo, Marrelli, Daniele, Piccioni, Stefania, De Pascale, Stefano, Graziosi, Luigina, Reddavid, Rossella, Rosa, Fausto, Belluco, Claudio, Tiberio, Guido, Rosa, Fausto (ORCID:0000-0002-7280-8354), Ministrini, Silvia, Bencivenga, Maria, Filippini, Federica, Mura, Gianni, Milandri, Carlo, Mazzei, Maria Antonietta, Bagnacci, Giulio, Berselli, Mattia, Monti, Manlio, Morgagni, Paolo, Solaini, Leonardo, Marrelli, Daniele, Piccioni, Stefania, De Pascale, Stefano, Graziosi, Luigina, Reddavid, Rossella, Rosa, Fausto, Belluco, Claudio, Tiberio, Guido, and Rosa, Fausto (ORCID:0000-0002-7280-8354)

Abstract

Introduction: The Italian Research Group for Gastric Cancer developed a prospective database about stage IV gastric cancer, to evaluate how a pragmatic attitude impacts the management of these patients. Materials and methods: We prospectively collected data about metastatic gastric cancer patients thanks to cooperation between radiologists, oncologists and surgeons and we analyzed survival and prognostic factors, comparing the results to those obtained in our retrospective study. Results: Three-hundred and eighty-three patients were enrolled from 2018 to September 2022. We observed a higher percentage of laparoscopic exploration with peritoneal lavage in the prospective cohort. In the registry only 3.6 % of patients was submitted to surgery without associated chemotherapy, while in the retrospective population 44.3 % of patients were operated on without any chemotherapy. At univariate and multivariate analyses, the different metastatic sites did not show any survival differences among each other (OS 20.0 vs 16.10 vs 16.7 months for lymphnodal, peritoneal and hepatic metastases, respectively), while the number of metastatic sites and the type of treatment showed a statistical significance (OS 16,7 vs 13,0 vs 4,5 months for 1, 2 and 3 different metastatic sites respectively, p < 0.001; 24,2 vs 12,0 vs 2,5 months for surgery with/without chemotherapy, chemotherapy alone and best supportive treatment respectively, p < 0.001). Conclusions: Our data highlight that the different metastatic sites did not show different survivals, but survival is worse in case of multiple localization. In patients where a curative resection can be achieved, acceptable survival rates are possible. A better diagnostic workup and a more accurate staging impact favorably upon survival.

Published
2024

40. Pathological response and outcome after neoadjuvant chemotherapy with DOC (docetaxel, oxaliplatin, capecitabine) or EOF (epirubicin, oxaliplatin, 5-fluorouracil) for clinical T3-T4 non-metastatic gastric cancer

Author

Petrioli, Roberto, Marrelli, Daniele, Roviello, Franco, D'Ignazio, Alessia, Torre, Pamela, Chirra, Martina, Savelli, Vinno, Ambrosio, Maria Raffaella, Francini, Guido, Calomino, Natale, Farsi, Marco, Vernillo, Remo, and Francini, Edoardo

Published
2020
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41. A pragmatic approach improves the clinical management of stage IV gastric cancer: Comparison between the Meta-Gastro results and the GIRCG's retrospective series

Author

Ministrini, Silvia, primary, Bencivenga, Maria, additional, Filippini, Federica, additional, Mura, Gianni, additional, Milandri, Carlo, additional, Mazzei, Maria Antonietta, additional, Bagnacci, Giulio, additional, Berselli, Mattia, additional, Monti, Manlio, additional, Morgagni, Paolo, additional, Solaini, Leonardo, additional, Marrelli, Daniele, additional, Piccioni, Stefania, additional, De Pascale, Stefano, additional, Graziosi, Luigina, additional, Reddavid, Rossella, additional, Rosa, Fausto, additional, Belluco, Claudio, additional, Tiberio, Guido, additional, Arizzi, Valeria, additional, Bloise, Francesco, additional, Cocozza, Eugenio, additional, Desio, Matteo, additional, Marchionini, Valentina, additional, Ascari, Filippo, additional, Donini, Annibale, additional, De Giuli, Maurizio, additional, Potenza, Enrico, additional, Pittiani, Frida, additional, Frittoli, Barbara, additional, Funicelli, Luigi, additional, and Cella, Chiara Alessandra, additional

Published
2024
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42. Oligometastatic Gastric Cancer: Clinical Data from the Meta-Gastro Prospective Register of the Italian Research Group on Gastric Cancer

Author

Bencivenga, Maria, primary, Ministrini, Silvia, additional, Morgagni, Paolo, additional, Mura, Gianni, additional, Marrelli, Daniele, additional, Milandri, Carlo, additional, Mazzei, Maria Antonietta, additional, Berselli, Mattia, additional, Monti, Manlio, additional, Graziosi, Luigina, additional, Reddavid, Rossella, additional, Rosa, Fausto, additional, Solaini, Leonardo, additional, Donini, Annibale, additional, Fumagalli Romario, Uberto, additional, Roviello, Franco, additional, de Manzoni, Giovanni, additional, and Tiberio, Guido Alberto Massimo, additional

Published
2023
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44. Looking for a strategy in treating peritoneal gastric cancer carcinomatosis: an Italian multicenter Gastric Cancer Research group’s analysis

Author

Graziosi, Luigina, Marino, Elisabetta, Bencivenga, Maria, D’Ignazio, Alessia, Solaini, Leonardo, Ministrini, Silvia, Caprioli, Michela, Sacco, Michele, Marrelli, Daniele, Mura, Gianni, Degiuli, Maurizio, Morgagni, Paolo, Tiberio, Guido Alberto Massimo, De Manzoni, Giovanni, Roviello, Franco, and Donini, Annibale

Published
2021
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49. Rituximab Treatment Prevents Lymphoma Onset in Gastric Cancer Patient-Derived Xenografts

Author

Corso, Simona, Cargnelutti, Marilisa, Durando, Stefania, Menegon, Silvia, Apicella, Maria, Migliore, Cristina, Capeloa, Tania, Ughetto, Stefano, Isella, Claudio, Medico, Enzo, Bertotti, Andrea, Sassi, Francesco, Sarotto, Ivana, Casorzo, Laura, Pisacane, Alberto, Mangioni, Monica, Sottile, Antonino, Degiuli, Maurizio, Fumagalli, Uberto, Sgroi, Giovanni, Molfino, Sarah, De Manzoni, Giovanni, Rosati, Riccardo, De Simone, Michele, Marrelli, Daniele, Saragoni, Luca, Rausei, Stefano, Pallabazzer, Giovanni, Roviello, Franco, Cassoni, Paola, Sapino, Anna, Bass, Adam, and Giordano, Silvia

Published
2018
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