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22 results on '"Marrer, Estelle"'

4. List of Contributors

Author

Andrade, Paula B., primary, Azam, Faisal, additional, Bernardi, Daniela, additional, de Boer, Rudolf, additional, Castellio, Luciano, additional, Cleland, Jon, additional, Dieterle, Frank, additional, Ferber, Georg, additional, Fernandes, João C., additional, Fishburn, C.Simone, additional, Glimm, Ekkehard, additional, Moreno, Palmira Granados, additional, Guzman, R.J., additional, High, Kevin P., additional, Jin, Ping, additional, Johansson, Lars, additional, Johnson, Rebecca, additional, Joly, Yann, additional, Karlsson, Cecilia, additional, Kerr, David J., additional, de Kleijn, D.P.V., additional, Kritchevsky, Stephen, additional, Lippi, Giuseppe, additional, Marincola, Francesco M., additional, Marrer, Estelle, additional, Meijers, Wouter C., additional, Meisel, Andreas, additional, Mergenthaler, Philipp, additional, Meyer-Lindenberg, Andreas, additional, Midgley, Rachel, additional, Moll, F.L., additional, Newport, Rhiana, additional, Padoan, Andrea, additional, Pasterkamp, G., additional, Peeters, W., additional, Pereira, David M., additional, Plebani, Mario, additional, Ren, Jiaqiang, additional, Sabatino, Marianna, additional, Schwarz, Emanuel, additional, Stingl, Julia, additional, Stroncek, David F., additional, Tost, Heike, additional, Valentão, Patrícia, additional, van der Velde, A. Rogier, additional, Vonderscher, Jacky, additional, Wang, Ena, additional, Wehling, Martin, additional, and Zaninotto, Martina, additional

Published
2015
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14. Heart Structure-Specific Transcriptomic Atlas Reveals Conserved microRNA-mRNA Interactions

Author

Vacchi-Suzzi, Caterina, primary, Hahne, Florian, additional, Scheubel, Philippe, additional, Marcellin, Magali, additional, Dubost, Valerie, additional, Westphal, Magdalena, additional, Boeglen, Catherine, additional, Büchmann-Møller, Stine, additional, Cheung, Ming Sin, additional, Cordier, André, additional, De Benedetto, Christopher, additional, Deurinck, Mark, additional, Frei, Moritz, additional, Moulin, Pierre, additional, Oakeley, Edward, additional, Grenet, Olivier, additional, Grevot, Armelle, additional, Stull, Robert, additional, Theil, Diethilde, additional, Moggs, Jonathan G., additional, Marrer, Estelle, additional, and Couttet, Philippe, additional

Published
2013
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15. Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies

Author

Vaidya, Vishal S, primary, Ozer, Josef S, additional, Dieterle, Frank, additional, Collings, Fitz B, additional, Ramirez, Victoria, additional, Troth, Sean, additional, Muniappa, Nagaraja, additional, Thudium, Douglas, additional, Gerhold, David, additional, Holder, Daniel J, additional, Bobadilla, Norma A, additional, Marrer, Estelle, additional, Perentes, Elias, additional, Cordier, André, additional, Vonderscher, Jacky, additional, Maurer, Gérard, additional, Goering, Peter L, additional, Sistare, Frank D, additional, and Bonventre, Joseph V, additional

Published
2010
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21. Global Transcriptome Analysis of the Responses of a Fluoroquinolone-Resistant Streptococcus pneumoniaeMutant and Its Parent to Ciprofloxacin

Author

Marrer, Estelle, Satoh, A. Tatsuo, Johnson, Margaret M., Piddock, Laura J. V., and Page, Malcolm G. P.

Abstract

ABSTRACTStreptococcus pneumoniaeM22 is a multidrug-resistant mutant selected after exposure of capsulated wild-type S. pneumoniaeNCTC 7465 (strain M4) to ciprofloxacin. DNA microarray analysis comparing the gene expression profiles of strain M22 with those of strain M4 showed that strain M22 constitutively expressed 22 genes at levels higher than those observed in strain M4 under all conditions studied. These included the genes encoding the enzymes involved in branched-chain amino acid biosynthesis and two genes (patAand patB) with sequences suggestive of ABC transporter proteins. Expression of the patAand patBgenes was induced by ciprofloxacin in both strains, but in strain M4 it only reached the levels observed in strain M22 after long incubation with high concentrations of ciprofloxacin. The altered expression profile observed with strain M22 suggested that the mutation or mutations acquired during resistance selection bring the cell into a state in which the expression of critical genes is preemptively altered to correct for the potential effects of ciprofloxacin on gene expression in the parent strain.

Published
2006
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22. Monitoring kidney safety in drug development: emerging technologies and their implications.

Author

Dieterle F, Marrer E, Suzuki E, Grenet O, Cordier A, and Vonderscher J

Subjects
Animals, Clinical Trials as Topic, Drug Design, Drug Evaluation, Preclinical, Genomics, Humans, Kidney Diseases diagnostic imaging, Kidney Diseases genetics, Legislation, Drug, Renal Circulation physiology, Safety, Ultrasonography, Drug-Related Side Effects and Adverse Reactions, Kidney Diseases chemically induced, Kidney Diseases diagnosis
Abstract

Drug-induced kidney injury is a serious and not uncommon adverse event which needs to be considered during drug development. The current standards used to monitor kidney function, such as blood urea nitrogen and serum creatinine, are late indicators of kidney injury and thus do not allow for timely intervention before loss of function. Improving the diagnosis and monitoring of kidney damage goes hand-in-hand with the identification of new biomarkers and the development of technologies that enable their sensitive and specific measurements. In order to move beyond restriction to internal company decisions, every entity that demonstrates the qualities of a biomarker must gain acceptance by health authorities if it is to be used for regulatory decision making in preclinical studies and clinical trials. This review focuses on the most promising achievements of new technologies applied to monitoring drug-induced nephrotoxicity (eg, gene expression, imaging, in vitro screening, protein assays) and on the use and implications of peripheral biomarkers such as the urinary protein biomarkers glutathione S-transferase-alpha, N-acetyl-beta-d-glucosaminidase, total protein, cystatin C, beta2-microglobulin, KIM-1, lipocalin-2 and serum cystatin C. Finally, the associated regulatory processes for use in clinics are also discussed.

Published
2008

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