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22. Epidemiology

Author

Fixa, B., Komárková, O., Krejsek, K., Bures, J., Nozicka, Z., Giorcelli, W., Rodi, M., Camisasca, G., Martinotti, R. G., Mendall, M. A., Goggin, P. M., Molineaux, Nicola, Levy, Joanne, Toosy, T., Strachan, D., Northfield, T. C., Vorobjova, T., Vassiljev, V., Kisand, K., Wadström, T., Uibo, R., Zotz, R. B., Xu, S. G., Recklinghausen, G. von, Meusers, P., Goebell, H., Rhee, K. H, Youn, H. S., Paik, S. K., Lee, W. K., Cho, M. J., Park, C. K., Li, Yuyuan, Hu, Pinjin, Du, Guoguang, Wong, Zhijin, Hazell, Stuart L., Mitchell, Hazel M., Korwin, J. D. de, Remot, P., Hartemann, Ph, Catelle, A., Conroy, M. C., Schmitt, J., Stolte, M., Wellens, E., Bethke, B., Ritter, M., Eidt, H., Zanten, S. Veldhuyzen van, Best, L., Bezanson, G., Marrie, T., Poniewierka, E., Gosciniak, G., Matysiak-Budnik, T., Quatrini, M., Boni, F., Baldassarri, A. R., Vecchi, A. De, Castelnovo, C., Viganò, E., Tenconi, L., Bianchi, P. A., Carlucci, A., Ferrini, G., Bianco, I, Larcinese, G., Sciascio, A. Di, Fly, G. F., Hauge, T., Persson, J., Coelho, L. G. V., Teixeira, M. M., Passos, M. C. F., Givisiez, C. B., Santos, C. M. F. R., Rodrigues, C. J. S., Chausson, Y., Castro, L. P., Hyvärinen, Hannu, Seppälä, Kari, Kivilaakso, Eero, Kosunen, Timo, Gormse, Martin, Pilotto, A., Vianello, F., Tornaboni, D., Dotto, P., Battaglia, G., Binda, F., Mario, F. Di, Donisi, P. M., Pasini, M., Benve-nuti, M. E., Stracca-Pansa, V., Pasquino, M., Jablonowski, H., Szelényi, H., Hengels, K. J., Strohmeyer, G., Banatvala, N., Mayo, K., Megraud, F., Jennings, R., Deeks, J. J., Feldman, R. A., Bulighin, G., Ederie, A., Pilati, S., Franzin, G., Zamboni, G., Maran, M., Musola, R., Tobin, A., Hackman, R. C., McDonald, G. B., Fatela, N., Cristino, J. Melo, Monteiro, L., Ramalho, F., Saragoça, A., Salgado, M. J., Moura, M. Cameiro de, Pretolani, S., Gasbarrini, G., Bonvicini, F., Baraldini, M., Tonelli, E., Gatto, M. R. A., Ghironzi, G. C., égraud, F. M, Bouchard, S., Lubcvzumiska-Kowalska, W., Knapik, Z., Meenan, J., Goggins, M., Shahi, C., Keeling, P. W. N., Keane, C., Weir, D. G., Vaira, D., Miglioli, M., Mulè, P., Holten, J., Menegati, M., Biasco, G., Vergura, M., Nannetti, A., Barbara, L., Boschini, A., Begnini, M., Menegatti, M., Ghira, C., D’Errico, A., Evans, D. G., Asnicar, M. A., Evans, D. J., Graham, D. Y., Lee, C. H., Coschieri, M., Fosse, T., Paul, M. C. St., Michiels, J. R., Delmont, J. P., Péroux, J. L., Pradier, C., Rampai, P., Pazzi, P., Merighi, A., Gamberini, S., Scarliarini, R., Bicochi, R., Libanore, M., Bisi, G., and Gulllini, S.

Published
1992
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27. HIV infection does not influence clinical outcomes in hospitalized patients with bacterial community-acquired pneumonia: results from the CAPO international cohort study

Author

Christensen, D., Feldman, C., Rossi, P., Marrie, T., Blasi, F., Luna, C., Fernandez, P., Porras, J., Martinez, J., Weiss, K., Levy, G., Lode, H., Gross, P., File, T., and Ramirez, J.

Subjects
Bacterial pneumonia -- Case studies, Pneumonia -- Case studies, HIV infection -- Case studies, Health, Health care industry
Published
2005

29. Macrolide therapy is associated with lower mortality in community-acquired bacteraemic pneumonia

Author

Arnold, FW, Lopardo, G, Wiemken, TL, Kelley, R, Peyrani, P, Mattingly, WA, Feldman, C, Gnoni, M, Maurici, R, Ramirez, JA, Arnold, F, Ramirez, J, Ayesu, K, File, T, Burdette, S, Blatt, S, Restrepo, M, Bordon, J, Gross, P, Musher, D, Marrie, T, Weiss, K, Roig, J, Lode, H, Welte, T, Aliberti, S, Blasi, F, Cosentini, R, Legnani, D, Franzetti, F, Montano, N, Cervi, G, Rossi, P, Voza, A, Ostrowsky, B, Pesci, A, Nava, S, Vialea, P, Galavatti, V, Patricia, A, Dimas, C, Piro, R, Viscoli, C, Torres, A, Valenti, V, Ojales, DP, Bodi, M, Porras, J, Rello, J, Menendez, R, Stolz, D, Schuetz, P, Haubitz, S, Chalmers, J, Fardon, T, Benchetrit, G, Rodriguez, E, Corral, J, Gonzalez, J, de Vedia, L, Luna, C, Martinez, J, Marzoratti, L, Rodriguez, M, Videla, A, Saavedra, F, Lopez, H, Victorio, C, Riera, F, Jimenez, P, Fernandez, P, Parada, M, Fuenzalida, AD, Riquelme, R, Barros, M, Luna, JM, Toala, I, de Morvil, GAO, Fernandez, R, Aiello, G, Alvarez, P, Soca, A, Arteta, F, Delgado, J, Levy, G, Rivero, L, Rodriguez, B, Mirabal, MP, Mateo, M, Mendoza, M, and CAPO

Subjects
Community-acquired pneumonia, Antimicrobial treatment, Bacteremia, Mortality
Abstract

Background: Community-acquired pneumonia (CAP) has a potential complication of bacteremia. The objective of this study was to define the clinical outcomes of patients with CAP and bacteremia treated with and without a macrolide. Materials and methods: Secondary analysis of the Community-Acquired Pneumonia Organization database of hospitalized patients with CAP. Patients with a positive blood culture were categorized based on the presence or absence of a macrolide in their initial antimicrobial regimen, and severity of their CAP. Outcomes included inhospital all-cause mortality, 30-day mortality, length of stay, and time to clinical stability. Results: Among 549 patients with CAP and bacteremia, 247 (45%) were treated with a macrolide and 302 (55%) were not. The primary pathogen was Streptococcus pneumoniae (74%). Poisson regression with robust error variance models were used to compare the adjusted effects of each study group on the outcomes. The unadjusted 30-day mortality was 18.4% in the macrolide group, and 29.6% in the non-macrolide group (adjusted relative risk (aRR)0.81; 95% confidence interval (CI)0.50-1.33; P = 0.41). Unadjusted in-hospital all-cause mortality was 7.3% in the macrolide group, and 18.9% in the non-macrolide group (aRR 0.54, 95% CI 0.30-0.98; P = 0.043). Length of stay and time to clinical stability were not significantly different. Conclusions: In-hospital mortality, but not 30-day mortality, was significantly better in the macrolide group. Our data support the use of a macrolide in hospitalized patients with CAP and bacteraemia.

Published
2018

30. Macrolide therapy is associated with lower mortality in community-acquired bacteraemic pneumonia

Author

Arnold, F, Lopardo, G, Wiemken, T, Kelley, R, Peyrani, P, Mattingly, W, Feldman, C, Gnoni, M, Maurici, R, Ramirez, J, Ayesu, K, File, T, Burdette, S, Blatt, S, Restrepo, M, Bordon, J, Gross, P, Musher, D, Marrie, T, Weiss, K, Roig, J, Lode, H, Welte, T, Aliberti, S, Blasi, F, Cosentini, R, Legnani, D, Franzetti, F, Montano, N, Cervi, G, Rossi, P, Voza, A, Ostrowsky, B, Pesci, A, Nava, S, Viale, P, Galavatti, V, Patricia, A, Dimas, C, Piro, R, Viscoli, C, Torres, A, Valenti, V, Ojales, D, Bodi, M, Porras, J, Rello, J, Menendez, R, Stolz, D, Schuetz, P, Haubitz, S, Chalmers, J, Fardon, T, Benchetrit, G, Rodriguez, E, Corral, J, Gonzalez, J, de Vedia, L, Luna, C, Martinez, J, Marzoratti, L, Rodriguez, M, Videla, A, Saavedra, F, Lopez, H, Victorio, C, Riera, F, Jimenez, P, Fernandez, P, Parada, M, Fuenzalida, A, Riquelme, R, Barros, M, Luna, J, Toala, I, Oze de Morvil, G, Fernandez, R, Aiello, G, Alvarez, P, Soca, A, Arteta, F, Delgado, J, Levy, G, Rivero, L, Rodriguez, B, Mirabal, M, Mateo, M, Mendoza, M, Arnold, Forest W., Lopardo, Gustavo, Wiemken, Timothy L., Kelley, Robert, Peyrani, Paula, Mattingly, William A., Feldman, Charles, Gnoni, Martin, Maurici, Rosemeri, Ramirez, Julio A., Arnold, Forest, Ramirez, Julio, Ayesu, Kwabena, File, Thomas, Burdette, Steven, Blatt, Stephen, Restrepo, Marcos, Bordon, Jose, Gross, Peter, Musher, Daniel, Marrie, Thomas, Weiss, Karl, Roig, Jorge, Lode, Harmut, Welte, Tobias, Aliberti, Stephano, Blasi, Francesco, Cosentini, Roberto, Legnani, Delfino, Franzetti, Fabio, Montano, Nicola, Cervi, Giulia, Rossi, Paolo, Voza, Antonio, Ostrowsky, Belinda, Pesci, Alberto, Nava, Stefano, Viale, Pierluigi, Galavatti, Vanni, Patricia, Aruj, Dimas, Carlos, Piro, Roberto, Viscoli, Claudio, Torres, Antoni, Valenti, Vincenzo, Ojales, Daniel Portela, Bodi, Maria, Porras, Jose, Rello, Jordi, Menendez, Rosario, Stolz, Daiana, Schuetz, Philipp, Haubitz, Sebastian, Chalmers, James, Fardon, Tom, Benchetrit, Guillermo, Rodriguez, Eduardo, Corral, Jorge, Gonzalez, Jose, de Vedia, Lautaro, Luna, Carlos, Martinez, Jorge, Marzoratti, Lucia, Rodriguez, Maria, Videla, Alejandro, Saavedra, Federico, Lopez, Horacio, Victorio, Carlos, Riera, Fernando, Jimenez, Patricio, Fernandez, Patricia, Parada, Maria, Fuenzalida, Alejandro Díaz, Riquelme, Raul, Barros, Manuel, Luna, Juan Manuel, Toala, Ivan, Oze de Morvil, Guillermo Arbo, Fernandez, Ricardo, Aiello, Gonzalo, Alvarez, Pablo, Soca, Ana, Arteta, Federico, Delgado, Jose, Levy, Gur, Rivero, Ludwig, Rodriguez, Benito, Mirabal, Mario Perez, Mateo, Marilyn, Mendoza, Myrna, Arnold, F, Lopardo, G, Wiemken, T, Kelley, R, Peyrani, P, Mattingly, W, Feldman, C, Gnoni, M, Maurici, R, Ramirez, J, Ayesu, K, File, T, Burdette, S, Blatt, S, Restrepo, M, Bordon, J, Gross, P, Musher, D, Marrie, T, Weiss, K, Roig, J, Lode, H, Welte, T, Aliberti, S, Blasi, F, Cosentini, R, Legnani, D, Franzetti, F, Montano, N, Cervi, G, Rossi, P, Voza, A, Ostrowsky, B, Pesci, A, Nava, S, Viale, P, Galavatti, V, Patricia, A, Dimas, C, Piro, R, Viscoli, C, Torres, A, Valenti, V, Ojales, D, Bodi, M, Porras, J, Rello, J, Menendez, R, Stolz, D, Schuetz, P, Haubitz, S, Chalmers, J, Fardon, T, Benchetrit, G, Rodriguez, E, Corral, J, Gonzalez, J, de Vedia, L, Luna, C, Martinez, J, Marzoratti, L, Rodriguez, M, Videla, A, Saavedra, F, Lopez, H, Victorio, C, Riera, F, Jimenez, P, Fernandez, P, Parada, M, Fuenzalida, A, Riquelme, R, Barros, M, Luna, J, Toala, I, Oze de Morvil, G, Fernandez, R, Aiello, G, Alvarez, P, Soca, A, Arteta, F, Delgado, J, Levy, G, Rivero, L, Rodriguez, B, Mirabal, M, Mateo, M, Mendoza, M, Arnold, Forest W., Lopardo, Gustavo, Wiemken, Timothy L., Kelley, Robert, Peyrani, Paula, Mattingly, William A., Feldman, Charles, Gnoni, Martin, Maurici, Rosemeri, Ramirez, Julio A., Arnold, Forest, Ramirez, Julio, Ayesu, Kwabena, File, Thomas, Burdette, Steven, Blatt, Stephen, Restrepo, Marcos, Bordon, Jose, Gross, Peter, Musher, Daniel, Marrie, Thomas, Weiss, Karl, Roig, Jorge, Lode, Harmut, Welte, Tobias, Aliberti, Stephano, Blasi, Francesco, Cosentini, Roberto, Legnani, Delfino, Franzetti, Fabio, Montano, Nicola, Cervi, Giulia, Rossi, Paolo, Voza, Antonio, Ostrowsky, Belinda, Pesci, Alberto, Nava, Stefano, Viale, Pierluigi, Galavatti, Vanni, Patricia, Aruj, Dimas, Carlos, Piro, Roberto, Viscoli, Claudio, Torres, Antoni, Valenti, Vincenzo, Ojales, Daniel Portela, Bodi, Maria, Porras, Jose, Rello, Jordi, Menendez, Rosario, Stolz, Daiana, Schuetz, Philipp, Haubitz, Sebastian, Chalmers, James, Fardon, Tom, Benchetrit, Guillermo, Rodriguez, Eduardo, Corral, Jorge, Gonzalez, Jose, de Vedia, Lautaro, Luna, Carlos, Martinez, Jorge, Marzoratti, Lucia, Rodriguez, Maria, Videla, Alejandro, Saavedra, Federico, Lopez, Horacio, Victorio, Carlos, Riera, Fernando, Jimenez, Patricio, Fernandez, Patricia, Parada, Maria, Fuenzalida, Alejandro Díaz, Riquelme, Raul, Barros, Manuel, Luna, Juan Manuel, Toala, Ivan, Oze de Morvil, Guillermo Arbo, Fernandez, Ricardo, Aiello, Gonzalo, Alvarez, Pablo, Soca, Ana, Arteta, Federico, Delgado, Jose, Levy, Gur, Rivero, Ludwig, Rodriguez, Benito, Mirabal, Mario Perez, Mateo, Marilyn, and Mendoza, Myrna

Abstract

Background: Community-acquired pneumonia (CAP) has a potential complication of bacteremia. The objective of this study was to define the clinical outcomes of patients with CAP and bacteremia treated with and without a macrolide. Materials and methods: Secondary analysis of the Community-Acquired Pneumonia Organization database of hospitalized patients with CAP. Patients with a positive blood culture were categorized based on the presence or absence of a macrolide in their initial antimicrobial regimen, and severity of their CAP. Outcomes included in-hospital all-cause mortality, 30-day mortality, length of stay, and time to clinical stability. Results: Among 549 patients with CAP and bacteremia, 247 (45%) were treated with a macrolide and 302 (55%) were not. The primary pathogen was Streptococcus pneumoniae (74%). Poisson regression with robust error variance models were used to compare the adjusted effects of each study group on the outcomes. The unadjusted 30-day mortality was 18.4% in the macrolide group, and 29.6% in the non-macrolide group (adjusted relative risk (aRR)0.81; 95% confidence interval (CI)0.50–1.33; P = 0.41). Unadjusted in-hospital all-cause mortality was 7.3% in the macrolide group, and 18.9% in the non-macrolide group (aRR 0.54, 95% CI 0.30–0.98; P = 0.043). Length of stay and time to clinical stability were not significantly different. Conclusions: In-hospital mortality, but not 30-day mortality, was significantly better in the macrolide group. Our data support the use of a macrolide in hospitalized patients with CAP and bacteraemia

Published
2018

38. Chlamydia pneumoniae

Author

Marrie, T J

Subjects
Male, Pulmonary and Respiratory Medicine, Arteriosclerosis, Incidence, Humans, Female, Chlamydia Infections, Chlamydophila pneumoniae, Child, Antibodies, Bacterial, Research Article, Aged
Published
1993
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39. Risk factors for pneumococcal endocarditis.

Author

Marrie, T. J., Tyrrell, G. J., Majumdar, S. R., and Eurich, D. T.

Subjects
DIAGNOSIS of endocarditis, TREATMENT of endocarditis, INFECTIVE endocarditis, INTENSIVE care units, STREPTOCOCCAL diseases, INFECTIOUS disease transmission
Abstract

Bacteremia is one of the most common manifestations of invasive pneumococcal disease (IPD). One complication of bacteremia is endocarditis; yet, few studies have evaluated the overall incidence and risk factors for IPD-associated endocarditis. Thus, we evaluated the overall incidence and risk factors of endocarditis compared to those without endocarditis in a large population of IPD patients. We prospectively collected all IPD cases from 2000 to 2014 in Northern Alberta, Canada. Descriptive statistics were used to compare sociodemographic variables, clinical characteristics, and IPD-related outcomes between patients with and without endocarditis. Endocarditis complicated the course of only 28 (0.3%) of 3251 adult patients with IPD. Endocarditis patients were more likely to use illicit drugs and have a higher severity of illness at presentation (i.e., higher rate of altered mental status and rate of intensive care unit [ICU] utilization, p < 0.05); however, no other major risk factors were identified. New murmur development among endocarditis patients was common: 39.3% compared to 2.2% of non-endocarditis patients ( p < 0.001). The mortality rate of 39.3% was more than twice that of the rate of 14.7% for the patients with IPD but without endocarditis. There was no pneumococcal serotype predilection for endocarditis. Endocarditis is an uncommon complication of IPD, but, when present, is associated with a significantly increased risk of mortality. Overall, few specific risk factors were identified for IPD-related endocarditis, with the exception of illicit drug use. [ABSTRACT FROM AUTHOR]

Published
2018
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42. Swine Outbreak of Pandemic Influenza A Virus on a Canadian Research Farm Supports Human-to-Swine Transmission

Author

Forgie, S. E., primary, Keenliside, J., additional, Wilkinson, C., additional, Webby, R., additional, Lu, P., additional, Sorensen, O., additional, Fonseca, K., additional, Barman, S., additional, Rubrum, A., additional, Stigger, E., additional, Marrie, T. J., additional, Marshall, F., additional, Spady, D. W., additional, Hu, J., additional, Loeb, M., additional, Russell, M. L., additional, and Babiuk, L. A., additional

Published
2011
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48. Ovine-associated Q fever

Author

WEBSTER, D., primary, HAASE, D., additional, MARRIE, T. J., additional, CAMPBELL, N., additional, PETTIPAS, J., additional, DAVIDSON, R., additional, and HATCHETTE, T. F., additional

Published
2008
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50. HMDB: the Human Metabolome Database

Author

Wishart, D. S., primary, Tzur, D., additional, Knox, C., additional, Eisner, R., additional, Guo, A. C., additional, Young, N., additional, Cheng, D., additional, Jewell, K., additional, Arndt, D., additional, Sawhney, S., additional, Fung, C., additional, Nikolai, L., additional, Lewis, M., additional, Coutouly, M.-A., additional, Forsythe, I., additional, Tang, P., additional, Shrivastava, S., additional, Jeroncic, K., additional, Stothard, P., additional, Amegbey, G., additional, Block, D., additional, Hau, David. D., additional, Wagner, J., additional, Miniaci, J., additional, Clements, M., additional, Gebremedhin, M., additional, Guo, N., additional, Zhang, Y., additional, Duggan, G. E., additional, MacInnis, G. D., additional, Weljie, A. M., additional, Dowlatabadi, R., additional, Bamforth, F., additional, Clive, D., additional, Greiner, R., additional, Li, L., additional, Marrie, T., additional, Sykes, B. D., additional, Vogel, H. J., additional, and Querengesser, L., additional

Published
2007
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