138 results on '"Martín-Martín, Natalia"'
Search Results
2. Angiocrine polyamine production regulates adiposity
- Author
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Monelli, Erika, Villacampa, Pilar, Zabala-Letona, Amaia, Martinez-Romero, Anabel, Llena, Judith, Beiroa, Daniel, Gouveia, Leonor, Chivite, Iñigo, Zagmutt, Sebastián, Gama-Perez, Pau, Osorio-Conles, Oscar, Muixi, Laia, Martinez-Gonzalez, Ainara, Castillo, Sandra D., Martín-Martín, Natalia, Castel, Pau, Valcarcel-Jimenez, Lorea, Garcia-Gonzalez, Irene, Villena, Josep A., Fernandez-Ruiz, Sonia, Serra, Dolors, Herrero, Laura, Benedito, Rui, Garcia-Roves, Pablo, Vidal, Josep, Cohen, Paul, Nogueiras, Rubén, Claret, Marc, Carracedo, Arkaitz, and Graupera, Mariona more...
- Published
- 2022
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- View/download PDF
Catalog
3. The PP2A regulator IER5L supports prostate cancer progression.
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Crespo, Jana R., Martín-Martín, Natalia, Garcia-Longarte, Saioa, Corres-Mendizabal, Jon, Carlevaris, Onintza, Astobiza, Ianire, Zabala-Letona, Amaia, Guiu, Marc, Azkargorta, Mikel, Gonzalez-Lopez, Monika, Macías-Cámara, Nuria, Doan, Phuong, Elortza, Félix, Mendizabal, Isabel, Westermack, Jukka, Gomis, Roger R., Ercilla, Amaia, and Carracedo, Arkaitz more...
- Published
- 2024
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4. Suppl Table 2 from CANCERTOOL: A Visualization and Representation Interface to Exploit Cancer Datasets
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Cortazar, Ana R., primary, Torrano, Veronica, primary, Martín-Martín, Natalia, primary, Caro-Maldonado, Alfredo, primary, Camacho, Laura, primary, Hermanova, Ivana, primary, Guruceaga, Elizabeth, primary, Lorenzo-Martín, Luis F., primary, Caloto, Ruben, primary, Gomis, Roger R., primary, Apaolaza, Iñigo, primary, Quesada, Victor, primary, Trka, Jan, primary, Gomez-Muñoz, Antonio, primary, Vincent, Silvestre, primary, Bustelo, Xose R., primary, Planes, Francisco J., primary, Aransay, Ana M., primary, and Carracedo, Arkaitz, primary more...
- Published
- 2023
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- View/download PDF
5. Data from CANCERTOOL: A Visualization and Representation Interface to Exploit Cancer Datasets
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Cortazar, Ana R., primary, Torrano, Veronica, primary, Martín-Martín, Natalia, primary, Caro-Maldonado, Alfredo, primary, Camacho, Laura, primary, Hermanova, Ivana, primary, Guruceaga, Elizabeth, primary, Lorenzo-Martín, Luis F., primary, Caloto, Ruben, primary, Gomis, Roger R., primary, Apaolaza, Iñigo, primary, Quesada, Victor, primary, Trka, Jan, primary, Gomez-Muñoz, Antonio, primary, Vincent, Silvestre, primary, Bustelo, Xose R., primary, Planes, Francisco J., primary, Aransay, Ana M., primary, and Carracedo, Arkaitz, primary more...
- Published
- 2023
- Full Text
- View/download PDF
6. Supplementary Figure legends from CANCERTOOL: A Visualization and Representation Interface to Exploit Cancer Datasets
- Author
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Cortazar, Ana R., primary, Torrano, Veronica, primary, Martín-Martín, Natalia, primary, Caro-Maldonado, Alfredo, primary, Camacho, Laura, primary, Hermanova, Ivana, primary, Guruceaga, Elizabeth, primary, Lorenzo-Martín, Luis F., primary, Caloto, Ruben, primary, Gomis, Roger R., primary, Apaolaza, Iñigo, primary, Quesada, Victor, primary, Trka, Jan, primary, Gomez-Muñoz, Antonio, primary, Vincent, Silvestre, primary, Bustelo, Xose R., primary, Planes, Francisco J., primary, Aransay, Ana M., primary, and Carracedo, Arkaitz, primary more...
- Published
- 2023
- Full Text
- View/download PDF
7. Suppl Table 1 from CANCERTOOL: A Visualization and Representation Interface to Exploit Cancer Datasets
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Cortazar, Ana R., primary, Torrano, Veronica, primary, Martín-Martín, Natalia, primary, Caro-Maldonado, Alfredo, primary, Camacho, Laura, primary, Hermanova, Ivana, primary, Guruceaga, Elizabeth, primary, Lorenzo-Martín, Luis F., primary, Caloto, Ruben, primary, Gomis, Roger R., primary, Apaolaza, Iñigo, primary, Quesada, Victor, primary, Trka, Jan, primary, Gomez-Muñoz, Antonio, primary, Vincent, Silvestre, primary, Bustelo, Xose R., primary, Planes, Francisco J., primary, Aransay, Ana M., primary, and Carracedo, Arkaitz, primary more...
- Published
- 2023
- Full Text
- View/download PDF
8. Data from PPARδ Elicits Ligand-Independent Repression of Trefoil Factor Family to Limit Prostate Cancer Growth
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Martín-Martín, Natalia, primary, Zabala-Letona, Amaia, primary, Fernández-Ruiz, Sonia, primary, Arreal, Leire, primary, Camacho, Laura, primary, Castillo-Martin, Mireia, primary, Cortazar, Ana R., primary, Torrano, Verónica, primary, Astobiza, Ianire, primary, Zúñiga-García, Patricia, primary, Ugalde-Olano, Aitziber, primary, Loizaga-Iriarte, Ana, primary, Unda, Miguel, primary, Valcárcel-Jiménez, Lorea, primary, Arruabarrena-Aristorena, Amaia, primary, Piva, Marco, primary, Sánchez-Mosquera, Pilar, primary, Aransay, Ana M., primary, Gomez-Muñoz, Antonio, primary, Barrio, Rosa, primary, Sutherland, James D., primary, and Carracedo, Arkaitz, primary more...
- Published
- 2023
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- View/download PDF
9. Suppl Figures 1, 2, 3, 4, 5, 6 and legends from PPARδ Elicits Ligand-Independent Repression of Trefoil Factor Family to Limit Prostate Cancer Growth
- Author
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Martín-Martín, Natalia, primary, Zabala-Letona, Amaia, primary, Fernández-Ruiz, Sonia, primary, Arreal, Leire, primary, Camacho, Laura, primary, Castillo-Martin, Mireia, primary, Cortazar, Ana R., primary, Torrano, Verónica, primary, Astobiza, Ianire, primary, Zúñiga-García, Patricia, primary, Ugalde-Olano, Aitziber, primary, Loizaga-Iriarte, Ana, primary, Unda, Miguel, primary, Valcárcel-Jiménez, Lorea, primary, Arruabarrena-Aristorena, Amaia, primary, Piva, Marco, primary, Sánchez-Mosquera, Pilar, primary, Aransay, Ana M., primary, Gomez-Muñoz, Antonio, primary, Barrio, Rosa, primary, Sutherland, James D., primary, and Carracedo, Arkaitz, primary more...
- Published
- 2023
- Full Text
- View/download PDF
10. Supplementary figures from CANCERTOOL: A Visualization and Representation Interface to Exploit Cancer Datasets
- Author
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Cortazar, Ana R., primary, Torrano, Veronica, primary, Martín-Martín, Natalia, primary, Caro-Maldonado, Alfredo, primary, Camacho, Laura, primary, Hermanova, Ivana, primary, Guruceaga, Elizabeth, primary, Lorenzo-Martín, Luis F., primary, Caloto, Ruben, primary, Gomis, Roger R., primary, Apaolaza, Iñigo, primary, Quesada, Victor, primary, Trka, Jan, primary, Gomez-Muñoz, Antonio, primary, Vincent, Silvestre, primary, Bustelo, Xose R., primary, Planes, Francisco J., primary, Aransay, Ana M., primary, and Carracedo, Arkaitz, primary more...
- Published
- 2023
- Full Text
- View/download PDF
11. Suppl Table S1 from PPARδ Elicits Ligand-Independent Repression of Trefoil Factor Family to Limit Prostate Cancer Growth
- Author
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Martín-Martín, Natalia, primary, Zabala-Letona, Amaia, primary, Fernández-Ruiz, Sonia, primary, Arreal, Leire, primary, Camacho, Laura, primary, Castillo-Martin, Mireia, primary, Cortazar, Ana R., primary, Torrano, Verónica, primary, Astobiza, Ianire, primary, Zúñiga-García, Patricia, primary, Ugalde-Olano, Aitziber, primary, Loizaga-Iriarte, Ana, primary, Unda, Miguel, primary, Valcárcel-Jiménez, Lorea, primary, Arruabarrena-Aristorena, Amaia, primary, Piva, Marco, primary, Sánchez-Mosquera, Pilar, primary, Aransay, Ana M., primary, Gomez-Muñoz, Antonio, primary, Barrio, Rosa, primary, Sutherland, James D., primary, and Carracedo, Arkaitz, primary more...
- Published
- 2023
- Full Text
- View/download PDF
12. Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment
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Araujo, Angela M., primary, Abaurrea, Andrea, additional, Azcoaga, Peio, additional, López-Velazco, Joanna I., additional, Manzano, Sara, additional, Rodriguez, Javier, additional, Rezola, Ricardo, additional, Egia-Mendikute, Leire, additional, Valdés-Mora, Fátima, additional, Flores, Juana M., additional, Jenkins, Liam, additional, Pulido, Laura, additional, Osorio-Querejeta, Iñaki, additional, Fernández-Nogueira, Patricia, additional, Ferrari, Nicola, additional, Viera, Cristina, additional, Martín-Martín, Natalia, additional, Tzankov, Alexandar, additional, Eppenberger-Castori, Serenella, additional, Alvarez-Lopez, Isabel, additional, Urruticoechea, Ander, additional, Bragado, Paloma, additional, Coleman, Nicholas, additional, Palazón, Asís, additional, Carracedo, Arkaitz, additional, Gallego-Ortega, David, additional, Calvo, Fernando, additional, Isacke, Clare M., additional, Caffarel, María M., additional, and Lawrie, Charles H., additional more...
- Published
- 2022
- Full Text
- View/download PDF
13. Integrative analysis of transcriptomics and clinical data uncovers the tumor-suppressive activity of MITF in prostate cancer
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Valcarcel-Jimenez, Lorea, Macchia, Alice, Martín-Martín, Natalia, Cortazar, Ana Rosa, Schaub-Clerigué, Ariane, Pujana-Vaquerizo, Mikel, Fernández-Ruiz, Sonia, Lacasa-Viscasillas, Isabel, Santos-Martin, Aida, Loizaga-Iriarte, Ana, Unda-Urzaiz, Miguel, Hermanova, Ivana, Astobiza, Ianire, Graupera, Mariona, Starkova, Julia, Sutherland, James, Barrio, Rosa, Aransay, Ana M., Carracedo, Arkaitz, and Torrano, Verónica more...
- Published
- 2018
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14. The metabolic co-regulator PGC1α suppresses prostate cancer metastasis
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Torrano, Veronica, Valcarcel-Jimenez, Lorea, Cortazar, Ana Rosa, Liu, Xiaojing, Urosevic, Jelena, Castillo-Martin, Mireia, Fernández-Ruiz, Sonia, Morciano, Giampaolo, Caro-Maldonado, Alfredo, Guiu, Marc, Zúñiga-García, Patricia, Graupera, Mariona, Bellmunt, Anna, Pandya, Pahini, Lorente, Mar, Martín-Martín, Natalia, Sutherland, James David, Sanchez-Mosquera, Pilar, Bozal-Basterra, Laura, Zabala-Letona, Amaia, Arruabarrena-Aristorena, Amaia, Berenguer, Antonio, Embade, Nieves, Ugalde-Olano, Aitziber, Lacasa-Viscasillas, Isabel, Loizaga-Iriarte, Ana, Unda-Urzaiz, Miguel, Schultz, Nikolaus, Aransay, Ana Maria, Sanz-Moreno, Victoria, Barrio, Rosa, Velasco, Guillermo, Pinton, Paolo, Cordon-Cardo, Carlos, Locasale, Jason W., Gomis, Roger R., and Carracedo, Arkaitz more...
- Published
- 2016
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15. PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer
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Bioquímica y biología molecular, Cirugía, radiología y medicina física, Biokimika eta biologia molekularra, Kirurgia,erradiologia eta medikuntza fisikoa, Zabala Letona, Amaia, Arruabarrena Aristorena, Amaia, Fernández Ruiz, Sonia, Viera, Cristina, Carlevaris, Onintza, Ercilla Eguiarte, Amaia, Mendizabal, Isabel, Martín Mateos, Teresa, Macchia, Alice, Camacho Soguero, Laura, Pujana Vaquerizo, Mikel, Sánchez Mosquera, Pilar, Torrano Moya, Verónica, Martín Martín, Natalia, Zuñiga García, Patricia, Castillo Martín, Mireia, Ugalde Olano, Aitziber, Loizaga Iriarte, Ana, Unda Urzaiz, Jesús Miguel, Mato, José M., Berra Ramírez, Miren Edurne, Martínez Chantar, María Luz, Carracedo Pérez, Arkaitz, Bioquímica y biología molecular, Cirugía, radiología y medicina física, Biokimika eta biologia molekularra, Kirurgia,erradiologia eta medikuntza fisikoa, Zabala Letona, Amaia, Arruabarrena Aristorena, Amaia, Fernández Ruiz, Sonia, Viera, Cristina, Carlevaris, Onintza, Ercilla Eguiarte, Amaia, Mendizabal, Isabel, Martín Mateos, Teresa, Macchia, Alice, Camacho Soguero, Laura, Pujana Vaquerizo, Mikel, Sánchez Mosquera, Pilar, Torrano Moya, Verónica, Martín Martín, Natalia, Zuñiga García, Patricia, Castillo Martín, Mireia, Ugalde Olano, Aitziber, Loizaga Iriarte, Ana, Unda Urzaiz, Jesús Miguel, Mato, José M., Berra Ramírez, Miren Edurne, Martínez Chantar, María Luz, and Carracedo Pérez, Arkaitz more...
- Abstract
[EN] Glycine N-Methyltransferase (GNMT) is a metabolic enzyme that integrates metabolism and epigenetic regulation. The product of GNMT, sarcosine, has been proposed as a prostate cancer biomarker. This enzyme is predominantly expressed in the liver, brain, pancreas, and prostate tissue, where it exhibits distinct regulation. Whereas genetic alterations in GNMT have been associated to prostate cancer risk, its causal contribution to the development of this disease is limited to cell line-based studies and correlative human analyses. Here we integrate human studies, genetic mouse modeling, and cellular systems to characterize the regulation and function of GNMT in prostate cancer. We report that this enzyme is repressed upon activation of the oncogenic Phosphoinositide-3-kinase (PI3K) pathway, which adds complexity to its reported dependency on androgen signaling. Importantly, we demonstrate that expression of GNMT is required for the onset of invasive prostate cancer in a genetic mouse model. Altogether, our results provide further support of the heavy oncogenic signal-dependent regulation of GNMT in prostate cancer. more...
- Published
- 2022
16. Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment
- Author
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Bioquímica y biología molecular, Biokimika eta biologia molekularra, Araujo, Angela M., Abaurrea, Andrea, Azcoaga, Peio, López Velazco, Joanna I., Manzano, Sara, Rodríguez Martínez, Javier, Rezola, Ricardo, Egia Mendikute, Leire, Valdés Mora, Fátima, Flores, Juana M., Jenkins, Liam, Pulido, Laura, Osorio Querejeta, Iñaki, Fernández Nogueira, Patricia, Ferrari, Nicola, Viera, Cristina, Martín Martín, Natalia, Tzankov, Alexandar, Eppenberger Castori, Serenella, Álvarez López, Isabel, Urruticoechea, Ander, Bragado, Paloma, Coleman, Nicholas, Palazón, Asís, Carracedo Pérez, Arkaitz, Gallego Ortega, David, Calvo González, Fernando, Isacke, Clare M., Caffarel, María M., Lawrie, Charles, Bioquímica y biología molecular, Biokimika eta biologia molekularra, Araujo, Angela M., Abaurrea, Andrea, Azcoaga, Peio, López Velazco, Joanna I., Manzano, Sara, Rodríguez Martínez, Javier, Rezola, Ricardo, Egia Mendikute, Leire, Valdés Mora, Fátima, Flores, Juana M., Jenkins, Liam, Pulido, Laura, Osorio Querejeta, Iñaki, Fernández Nogueira, Patricia, Ferrari, Nicola, Viera, Cristina, Martín Martín, Natalia, Tzankov, Alexandar, Eppenberger Castori, Serenella, Álvarez López, Isabel, Urruticoechea, Ander, Bragado, Paloma, Coleman, Nicholas, Palazón, Asís, Carracedo Pérez, Arkaitz, Gallego Ortega, David, Calvo González, Fernando, Isacke, Clare M., Caffarel, María M., and Lawrie, Charles more...
- Abstract
[EN] The tumor microenvironment (TME) is reprogrammed by cancer cells and participates in all stages of tumor progression. The contribution of stromal cells to the reprogramming of the TME is not well understood. Here, we provide evidence of the role of the cytokine oncostatin M (OSM) as central node for multicellular interactions between immune and nonimmune stromal cells and the epithelial cancer cell compartment. OSM receptor (OSMR) deletion in a multistage breast cancer model halted tumor progression. We ascribed causality to the stromal function of the OSM axis by demonstrating reduced tumor burden of syngeneic tumors implanted in mice lacking OSMR. Single-cell and bioinformatic analysis of murine and human breast tumors revealed that OSM expression was restricted to myeloid cells, whereas OSMR was detected predominantly in fibroblasts and, to a lower extent, cancer cells. Myeloid-derived OSM reprogrammed fibroblasts to a more contractile and tumorigenic phenotype and elicited the secretion of VEGF and proinflammatory chemokines CXCL1 and CXCL16, leading to increased myeloid cell recruitment. Collectively, our data support the notion that the stromal OSM/OSMR axis reprograms the immune and nonimmune microenvironment and plays a key role in breast cancer progression. more...
- Published
- 2022
17. High SOX9 Maintains Glioma Stem Cell Activity through a Regulatory Loop Involving STAT3 and PML
- Author
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Bioquímica y biología molecular, Biokimika eta biologia molekularra, Aldaz Donamaría, Paula, Martín Martín, Natalia, Sáenz Antoñanzas, Ander, Carrasco-Garcia, Estefania, Álvarez-Satta, María, Elúa Pinin, Alejandro, Pollard, Steven M., Lawrie, Charles H., Moreno-Valladares, Manuel, Samprón Lebed, Nicolás, Hench, Jürgen, Lovell-Badge, Robin, Carracedo Pérez, Arkaitz, Matheu Fernández, Ander, Bioquímica y biología molecular, Biokimika eta biologia molekularra, Aldaz Donamaría, Paula, Martín Martín, Natalia, Sáenz Antoñanzas, Ander, Carrasco-Garcia, Estefania, Álvarez-Satta, María, Elúa Pinin, Alejandro, Pollard, Steven M., Lawrie, Charles H., Moreno-Valladares, Manuel, Samprón Lebed, Nicolás, Hench, Jürgen, Lovell-Badge, Robin, Carracedo Pérez, Arkaitz, and Matheu Fernández, Ander more...
- Abstract
Glioma stem cells (GSCs) are critical targets for glioma therapy. SOX9 is a transcription factor with critical roles during neurodevelopment, particularly within neural stem cells. Previous studies showed that high levels of SOX9 are associated with poor glioma patient survival. SOX9 knockdown impairs GSCs proliferation, confirming its potential as a target for glioma therapy. In this study, we characterized the function of SOX9 directly in patient-derived glioma stem cells. Notably, transcriptome analysis of GSCs with SOX9 knockdown revealed STAT3 and PML as downstream targets. Functional studies demonstrated that SOX9, STAT3, and PML form a regulatory loop that is key for GSC activity and self-renewal. Analysis of glioma clinical biopsies confirmed a positive correlation between SOX9/STAT3/PML and poor patient survival among the cases with the highest SOX9 expression levels. Importantly, direct STAT3 or PML inhibitors reduced the expression of SOX9, STAT3, and PML proteins, which significantly reduced GSCs tumorigenicity. In summary, our study reveals a novel role for SOX9 upstream of STAT3, as a GSC pathway regulator, and presents pharmacological inhibitors of the signaling cascade. more...
- Published
- 2022
18. Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment
- Author
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Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Eusko Jaurlaritza, Asociación Española Contra el Cáncer, European Commission, European Research Council, Ministerio de Economía y Competitividad (España), Fundación la Caixa, Cancer Council NSW (Australia), BBVA, Araujo, Angela M., Abaurrea, Andrea, Azcoaga, Peio, López-Velazco, Joanna I., Manzano, Sara, Rodríguez, Javier, Rezola, Ricardo, Egia-Mendikute, Leire, Valdés-Mora, Fátima, Flores, Juana M., Jenkins, Liam, Pulido, Laura, Osorio-Querejeta, Iñaki, Fernández-Nogueira, Patricia, Ferrari, Nicola, Viera, Cristina, Martín-Martín, Natalia, Tzankov, Alexandar, Eppenberger-Castori, Serenella, Álvarez-López, Isabel, Urruticoechea, Ander, Bragado, Paloma, Coleman, Nicholas, Palazón, Asís, Carracedo, Arkaitz, Gallego-Ortega, David, Calvo, Fernando, Isacke, Clare M., Caffarel, María M., Lawrie, Charles H., Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Eusko Jaurlaritza, Asociación Española Contra el Cáncer, European Commission, European Research Council, Ministerio de Economía y Competitividad (España), Fundación la Caixa, Cancer Council NSW (Australia), BBVA, Araujo, Angela M., Abaurrea, Andrea, Azcoaga, Peio, López-Velazco, Joanna I., Manzano, Sara, Rodríguez, Javier, Rezola, Ricardo, Egia-Mendikute, Leire, Valdés-Mora, Fátima, Flores, Juana M., Jenkins, Liam, Pulido, Laura, Osorio-Querejeta, Iñaki, Fernández-Nogueira, Patricia, Ferrari, Nicola, Viera, Cristina, Martín-Martín, Natalia, Tzankov, Alexandar, Eppenberger-Castori, Serenella, Álvarez-López, Isabel, Urruticoechea, Ander, Bragado, Paloma, Coleman, Nicholas, Palazón, Asís, Carracedo, Arkaitz, Gallego-Ortega, David, Calvo, Fernando, Isacke, Clare M., Caffarel, María M., and Lawrie, Charles H. more...
- Abstract
The tumor microenvironment (TME) is reprogrammed by cancer cells and participates in all stages of tumor progression. The contribution of stromal cells to the reprogramming of the TME is not well understood. Here, we provide evidence of the role of the cytokine oncostatin M (OSM) as central node for multicellular interactions between immune and nonimmune stromal cells and the epithelial cancer cell compartment. OSM receptor (OSMR) deletion in a multistage breast cancer model halted tumor progression. We ascribed causality to the stromal function of the OSM axis by demonstrating reduced tumor burden of syngeneic tumors implanted in mice lacking OSMR. Single-cell and bioinformatic analysis of murine and human breast tumors revealed that OSM expression was restricted to myeloid cells, whereas OSMR was detected predominantly in fibroblasts and, to a lower extent, cancer cells. Myeloid-derived OSM reprogrammed fibroblasts to a more contractile and tumorigenic phenotype and elicited the secretion of VEGF and proinflammatory chemokines CXCL1 and CXCL16, leading to increased myeloid cell recruitment. Collectively, our data support the notion that the stromal OSM/OSMR axis reprograms the immune and nonimmune microenvironment and plays a key role in breast cancer progression. more...
- Published
- 2022
19. High SOX9 Maintains Glioma Stem Cell Activity through a Regulatory Loop Involving STAT3 and PML
- Author
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Aldaz, Paula, primary, Martín-Martín, Natalia, additional, Saenz-Antoñanzas, Ander, additional, Carrasco-Garcia, Estefania, additional, Álvarez-Satta, María, additional, Elúa-Pinin, Alejandro, additional, Pollard, Steven M., additional, Lawrie, Charles H., additional, Moreno-Valladares, Manuel, additional, Samprón, Nicolás, additional, Hench, Jürgen, additional, Lovell-Badge, Robin, additional, Carracedo, Arkaitz, additional, and Matheu, Ander, additional more...
- Published
- 2022
- Full Text
- View/download PDF
20. Identification of Androgen Receptor Metabolic Correlome Reveals the Repression of Ceramide Kinase by Androgens
- Author
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Camacho, Laura, primary, Zabala-Letona, Amaia, additional, Cortazar, Ana R., additional, Astobiza, Ianire, additional, Dominguez-Herrera, Asier, additional, Ercilla, Amaia, additional, Crespo, Jana, additional, Viera, Cristina, additional, Fernández-Ruiz, Sonia, additional, Martinez-Gonzalez, Ainara, additional, Torrano, Veronica, additional, Martín-Martín, Natalia, additional, Gomez-Muñoz, Antonio, additional, and Carracedo, Arkaitz, additional more...
- Published
- 2021
- Full Text
- View/download PDF
21. Identification of Androgen Receptor Metabolic Correlome Reveals the Repression of Ceramide Kinase by Androgens
- Author
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Bioquímica y biología molecular, Biokimika eta biologia molekularra, Camacho Soguero, Laura, Zabala Letona, Amaia, Cortazar, Ana R., Astobiza, Ianire, Domínguez Herrera, Asier, Ercilla, Amaia, Crespo, Jana, Viera, Cristina, Fernández-Ruiz, Sonia, Martinez-Gonzalez, Ainara, Torrano Moya, Verónica, Martín-Martín, Natalia, Gómez Muñoz, Antonio, Carracedo Pérez, Arkaitz, Bioquímica y biología molecular, Biokimika eta biologia molekularra, Camacho Soguero, Laura, Zabala Letona, Amaia, Cortazar, Ana R., Astobiza, Ianire, Domínguez Herrera, Asier, Ercilla, Amaia, Crespo, Jana, Viera, Cristina, Fernández-Ruiz, Sonia, Martinez-Gonzalez, Ainara, Torrano Moya, Verónica, Martín-Martín, Natalia, Gómez Muñoz, Antonio, and Carracedo Pérez, Arkaitz more...
- Abstract
Prostate cancer (PCa) is one of the most prevalent cancers in men. Androgen receptor signaling plays a major role in this disease, and androgen deprivation therapy is a common therapeutic strategy in recurrent disease. Sphingolipid metabolism plays a central role in cell death, survival, and therapy resistance in cancer. Ceramide kinase (CERK) catalyzes the phosphorylation of ceramide to ceramide 1-phosphate, which regulates various cellular functions including cell growth and migration. Here we show that activated androgen receptor (AR) is a repressor of CERK expression. We undertook a bioinformatics strategy using PCa transcriptomics datasets to ascertain the metabolic alterations associated with AR activity. CERK was among the most prominent negatively correlated genes in our analysis. Interestingly, we demonstrated through various experimental approaches that activated AR reduces the mRNA expression of CERK: (i) expression of CERK is predominant in cell lines with low or negative AR activity; (ii) AR agonist and antagonist repress and induce CERK mRNA expression, respectively; (iii) orchiectomy in wildtype mice or mice with PCa (harboring prostate-specific Pten deletion) results in elevated Cerk mRNA levels in prostate tissue. Mechanistically, we found that AR represses CERK through interaction with its regulatory elements and that the transcriptional repressor EZH2 contributes to this process. In summary, we identify a repressive mode of AR that influences the expression of CERK in PCa. more...
- Published
- 2021
22. LUZP1 Controls Cell Division, Migration and Invasion Through Regulation of the Actin Cytoskeleton
- Author
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Bioquímica y biología molecular, Genética, antropología física y fisiología animal, Biokimika eta biologia molekularra, Genetika,antropologia fisikoa eta animalien fisiologia, Bozal Basterra, Laura, González Santamarta, María, Muratore, Verónica, Martín Martín, Natalia, Ercilla Eguiarte, Amaia, Rodríguez Pérez, José Antonio, Carracedo Pérez, Arkaitz, Sutherland, James D., Barrio Olano, María Rosa, Bioquímica y biología molecular, Genética, antropología física y fisiología animal, Biokimika eta biologia molekularra, Genetika,antropologia fisikoa eta animalien fisiologia, Bozal Basterra, Laura, González Santamarta, María, Muratore, Verónica, Martín Martín, Natalia, Ercilla Eguiarte, Amaia, Rodríguez Pérez, José Antonio, Carracedo Pérez, Arkaitz, Sutherland, James D., and Barrio Olano, María Rosa more...
- Abstract
LUZP1 is a centrosomal and actin cytoskeleton-localizing protein that regulates both ciliogenesis and actin filament bundling. As the cytoskeleton and cilia are implicated in metastasis and tumor suppression, we examined roles for LUZP1 in the context of cancer. Here we show that LUZP1 exhibits frequent genomic aberrations in cancer, with a predominance of gene deletions. Furthermore, we demonstrate that CRISPR/Cas9-mediated loss of Luzp1 in mouse fibroblasts promotes cell migration and invasion features, reduces cell viability, and increases cell apoptosis, centriole numbers, and nuclear size while altering the actin cytoskeleton. Loss of Luzp1 also induced changes to ACTR3 (Actin Related Protein 3, also known as ARP3) and phospho-cofilin ratios, suggesting regulatory roles in actin polymerization, beyond its role in filament bundling. Our results point to an unprecedented role for LUZP1 in the regulation of cancer features through the control of actin cytoskeleton. more...
- Published
- 2021
23. LUZP1 Controls Cell Division, Migration and Invasion Through Regulation of the Actin Cytoskeleton
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Bozal-Basterra, Laura, primary, Gonzalez-Santamarta, María, additional, Muratore, Veronica, additional, Martín-Martín, Natalia, additional, Ercilla, Amaia, additional, Rodríguez, Jose A., additional, Carracedo, Arkaitz, additional, Sutherland, James D., additional, and Barrio, Rosa, additional more...
- Published
- 2021
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24. Characterization of the biological and molecular activity of PML in breast cancer
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Carracedo Pérez, Arkaitz, Martín Martín, Natalia, Bioquímica y biología molecular, Biokimika eta biologia molekularra, Arreal López, Leire, Carracedo Pérez, Arkaitz, Martín Martín, Natalia, Bioquímica y biología molecular, Biokimika eta biologia molekularra, and Arreal López, Leire more...
- Abstract
253 p., Oncogene addiction postulates that the survival and growth of certain tumor cells is dependent upon the activity of one oncogene, despite their multiple genetic and epigenetic abnormalities. This phenomenon provides a foundation for molecular targeted therapy and a rationale for oncogene-based stratification. We previously reported that the Promyelocytic Leukemia protein (PML) is upregulated in triple negative breast cancer (TNBC) and it regulates cancer-initiating cell function, thus suggesting that this protein can be therapeutically targeted in combination with PML-based stratification. However, the effects of PML perturbation on the bulk of tumor cells remained poorly understood. In this thesis work we demonstrated that TNBC cells are addicted to the expression of this nuclear protein. PML inhibition led to a remarkable growth arrest combined with features of senescence in vitro and in vivo. Mechanistically, we observed that growth arrest and senescence were associated to a decrease in MYC and PIM1 kinase levels, with the subsequent accumulation of cyclin-dependent kinase inhibitor 1B (CDKN1B, p27), a trigger of senescence. In line with this notion, we found that PML is associated to thepromoter regions of MYC and PIM1, consistent with their direct correlation in breast cancer specimens. Altogether, our results provide a feasible explanation for the functional similarities of MYC, PIM1, and PML in TNBC and encourage further study of PML targeting strategies for the treatment of this breast cancer subtype. more...
- Published
- 2020
25. HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis
- Author
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Bioquímica y biología molecular, Biokimika eta biologia molekularra, Palomo Irigoyen, Marta, Pérez Andrés, Encarni, Iruarrizaga Lejarreta, Marta, Barreira Manrique, Adrián, Tamayo Caro, Miguel, Vila Vecilla, Laura, Moreno Cugnon, Leire, Beitia, Nagore, Medrano, Daniela, Fernández Ramos, David, Lozano, Juan José, Okawa, Satoshi, Lavín, José L., Martín Martín, Natalia, Sutherland, James D., Guitiérez de Juan, Virginia, González López, Monika, Macías Cámara, Nuria, Mosén Ansorena, David, Laraba, Liyam, Hanemann, C. Oliver, Ercolano, Emanuela, Parkinson, David B., Schultz, Christopher W., Araúzo Bravo, Marcos J., Ascensión, Alex M., Gerovska, Daniela, Iribar, Haizea, Izeta, Ander, Pytel, Peter, Krastel, Philipp, Provenzani, Alessandro, Seneci, Pierfausto, Carrasco, Ruben D., Del Sol, Antonio, Martínez Chantar, María Luz, Barrio Olano, María Rosa, Serra, Eduard, Lazaro, Conxi, Flanagan, Adrienne M., Gorospe, Myriam, Ratner, Nancy, Aransay Bañares, Ana María, Carracedo Pérez, Arkaitz, Varela Rey, Marta, Woodhoo, Ashwin, Bioquímica y biología molecular, Biokimika eta biologia molekularra, Palomo Irigoyen, Marta, Pérez Andrés, Encarni, Iruarrizaga Lejarreta, Marta, Barreira Manrique, Adrián, Tamayo Caro, Miguel, Vila Vecilla, Laura, Moreno Cugnon, Leire, Beitia, Nagore, Medrano, Daniela, Fernández Ramos, David, Lozano, Juan José, Okawa, Satoshi, Lavín, José L., Martín Martín, Natalia, Sutherland, James D., Guitiérez de Juan, Virginia, González López, Monika, Macías Cámara, Nuria, Mosén Ansorena, David, Laraba, Liyam, Hanemann, C. Oliver, Ercolano, Emanuela, Parkinson, David B., Schultz, Christopher W., Araúzo Bravo, Marcos J., Ascensión, Alex M., Gerovska, Daniela, Iribar, Haizea, Izeta, Ander, Pytel, Peter, Krastel, Philipp, Provenzani, Alessandro, Seneci, Pierfausto, Carrasco, Ruben D., Del Sol, Antonio, Martínez Chantar, María Luz, Barrio Olano, María Rosa, Serra, Eduard, Lazaro, Conxi, Flanagan, Adrienne M., Gorospe, Myriam, Ratner, Nancy, Aransay Bañares, Ana María, Carracedo Pérez, Arkaitz, Varela Rey, Marta, and Woodhoo, Ashwin more...
- Abstract
Cancer cells can develop a strong addiction to discrete molecular regulators, which control the aberrant gene expression programs that drive and maintain the cancer phenotype. Here, we report the identification of the RNA-binding protein HuR/ELAVL1 as a central oncogenic driver for malignant peripheral nerve sheath tumors (MPNSTs), which are highly aggressive sarcomas that originate from cells of the Schwann cell lineage. HuR was found to be highly elevated and bound to a multitude of cancer-associated transcripts in human MPNST samples. Accordingly, genetic and pharmacological inhibition of HuR had potent cytostatic and cytotoxic effects on tumor growth, and strongly suppressed metastatic capacity in vivo. Importantly, we linked the profound tumorigenic function of HuR to its ability to simultaneously regulate multiple essential oncogenic pathways in MPNST cells, including the Wnt/beta-catenin, YAP/TAZ, RB/E2F, and BET pathways, which converge on key transcriptional networks. Given the exceptional dependency of MPNST cells on HuR for survival, proliferation, and dissemination, we propose that HuR represents a promising therapeutic target for MPNST treatment. more...
- Published
- 2020
26. Targeting PML in triple negative breast cancer elicits growth suppression and senescence
- Author
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Bioquímica y biología molecular, Biokimika eta biologia molekularra, Arreal López, Leire, Piva, Marco, Fernández Ruiz, Sonia, Revandkar, Ajinkya, Schaub Clerigué, Ariane, Villanueva, Josep, Zabala Letona, Amaia, Pujana Vaquerizo, Mikel, Astobiza Pérez, Ianire, Cortázar, Ana Rosa, Hermanova, Ivana, Bozal Basterra, Laura, Arruabarrena Aristorena, Amaia, Crespo, Jana R., Valcárcel Jiménez, Lorea, Zuñiga García, Patricia, Canals, Francesc, Torrano Moya, Verónica, Barrio Olano, María Rosa, Sutherland, James D., Alimonti, Andrea, Martín Martín, Natalia, Carracedo Pérez, Arkaitz, Bioquímica y biología molecular, Biokimika eta biologia molekularra, Arreal López, Leire, Piva, Marco, Fernández Ruiz, Sonia, Revandkar, Ajinkya, Schaub Clerigué, Ariane, Villanueva, Josep, Zabala Letona, Amaia, Pujana Vaquerizo, Mikel, Astobiza Pérez, Ianire, Cortázar, Ana Rosa, Hermanova, Ivana, Bozal Basterra, Laura, Arruabarrena Aristorena, Amaia, Crespo, Jana R., Valcárcel Jiménez, Lorea, Zuñiga García, Patricia, Canals, Francesc, Torrano Moya, Verónica, Barrio Olano, María Rosa, Sutherland, James D., Alimonti, Andrea, Martín Martín, Natalia, and Carracedo Pérez, Arkaitz more...
- Abstract
Oncogene addiction postulates that the survival and growth of certain tumor cells is dependent upon the activity of one oncogene, despite their multiple genetic and epigenetic abnormalities. This phenomenon provides a foundation for molecular targeted therapy and a rationale for oncogene-based stratification. We have previously reported that the Promyelocytic Leukemia protein (PML) is upregulated in triple negative breast cancer (TNBC) and it regulates cancer-initiating cell function, thus suggesting that this protein can be therapeutically targeted in combination with PML-based stratification. However, the effects of PML perturbation on the bulk of tumor cells remained poorly understood. Here we demonstrate that TNBC cells are addicted to the expression of this nuclear protein. PML inhibition led to a remarkable growth arrest combined with features of senescence in vitro and in vivo. Mechanistically, the growth arrest and senescence were associated to a decrease in MYC and PIM1 kinase levels, with the subsequent accumulation of CDKN1B (p27), a trigger of senescence. In line with this notion, we found that PML is associated to the promoter regions of MYC and PIM1, consistent with their direct correlation in breast cancer specimens. Altogether, our results provide a feasible explanation for the functional similarities of MYC, PIM1, and PML in TNBC and encourage further study of PML targeting strategies for the treatment of this breast cancer subtype. more...
- Published
- 2020
27. Stromal Oncostatin M axis promotes breast cancer progression
- Author
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Araujo, Angela M., primary, Abaurrea, Andrea, additional, Azcoaga, Peio, additional, López-Velazco, Joanna I., additional, Rezola, Ricardo, additional, Osorio-Querejeta, Iñaki, additional, Valdés-Mora, Fátima, additional, Flores, Juana M., additional, Jenkins, Liam, additional, Fernández-Nogueira, Patricia, additional, Ferrari, Nicola, additional, Martín-Martín, Natalia, additional, Tzankov, Alexandar, additional, Eppenberger-Castori, Serenella, additional, Alvarez-Lopez, Isabel, additional, Urruticoechea, Ander, additional, Bragado, Paloma, additional, Coleman, Nicholas, additional, Carracedo, Arkaitz, additional, Gallego-Ortega, David, additional, Calvo, Fernando, additional, Isacke, Clare M., additional, Caffarel, Maria M., additional, and Lawrie, Charles H., additional more...
- Published
- 2020
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28. LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is a contributing factor in Townes-Brocks Syndrome
- Author
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Bozal-Basterra, Laura, primary, Gonzalez-Santamarta, María, additional, Muratore, Veronica, additional, Bermejo-Arteagabeitia, Aitor, additional, Da Fonseca, Carolina, additional, Barroso-Gomila, Orhi, additional, Azkargorta, Mikel, additional, Iloro, Ibon, additional, Pampliega, Olatz, additional, Andrade, Ricardo, additional, Martín-Martín, Natalia, additional, Branon, Tess C, additional, Ting, Alice Y, additional, Rodríguez, Jose A, additional, Carracedo, Arkaitz, additional, Elortza, Felix, additional, Sutherland, James D, additional, and Barrio, Rosa, additional more...
- Published
- 2020
- Full Text
- View/download PDF
29. HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis
- Author
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Palomo-Irigoyen, Marta, primary, Pérez-Andrés, Encarni, additional, Iruarrizaga-Lejarreta, Marta, additional, Barreira-Manrique, Adrián, additional, Tamayo-Caro, Miguel, additional, Vila-Vecilla, Laura, additional, Moreno-Cugnon, Leire, additional, Beitia, Nagore, additional, Medrano, Daniela, additional, Fernández-Ramos, David, additional, Lozano, Juan José, additional, Okawa, Satoshi, additional, Lavín, José L., additional, Martín-Martín, Natalia, additional, Sutherland, James D., additional, de Juan, Virginia Guitiérez, additional, Gonzalez-Lopez, Monika, additional, Macías-Cámara, Nuria, additional, Mosén-Ansorena, David, additional, Laraba, Liyam, additional, Hanemann, C. Oliver, additional, Ercolano, Emanuela, additional, Parkinson, David B., additional, Schultz, Christopher W., additional, Araúzo-Bravo, Marcos J., additional, Ascensión, Alex M., additional, Gerovska, Daniela, additional, Iribar, Haizea, additional, Izeta, Ander, additional, Pytel, Peter, additional, Krastel, Philipp, additional, Provenzani, Alessandro, additional, Seneci, Pierfausto, additional, Carrasco, Ruben D., additional, Del Sol, Antonio, additional, Martinez-Chantar, María Luz, additional, Barrio, Rosa, additional, Serra, Eduard, additional, Lazaro, Conxi, additional, Flanagan, Adrienne M., additional, Gorospe, Myriam, additional, Ratner, Nancy, additional, Aransay, Ana M., additional, Carracedo, Arkaitz, additional, Varela-Rey, Marta, additional, and Woodhoo, Ashwin, additional more...
- Published
- 2020
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30. Author response: LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is a contributing factor in Townes-Brocks Syndrome
- Author
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Bozal-Basterra, Laura, primary, Gonzalez-Santamarta, María, additional, Muratore, Veronica, additional, Bermejo-Arteagabeitia, Aitor, additional, Da Fonseca, Carolina, additional, Barroso-Gomila, Orhi, additional, Azkargorta, Mikel, additional, Iloro, Ibon, additional, Pampliega, Olatz, additional, Andrade, Ricardo, additional, Martín-Martín, Natalia, additional, Branon, Tess C, additional, Ting, Alice Y, additional, Rodríguez, Jose A, additional, Carracedo, Arkaitz, additional, Elortza, Felix, additional, Sutherland, James D, additional, and Barrio, Rosa, additional more...
- Published
- 2020
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31. Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer
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Hermanova, Ivana, primary, Zúñiga-García, Patricia, additional, Caro-Maldonado, Alfredo, additional, Fernandez-Ruiz, Sonia, additional, Salvador, Fernando, additional, Martín-Martín, Natalia, additional, Zabala-Letona, Amaia, additional, Nuñez-Olle, Marc, additional, Torrano, Verónica, additional, Camacho, Laura, additional, Lizcano, Jose M., additional, Talamillo, Ana, additional, Carreira, Suzanne, additional, Gurel, Bora, additional, Cortazar, Ana R., additional, Guiu, Marc, additional, López, Jose I., additional, Martinez-Romero, Anabel, additional, Astobiza, Ianire, additional, Valcarcel-Jimenez, Lorea, additional, Lorente, Mar, additional, Arruabarrena-Aristorena, Amaia, additional, Velasco, Guillermo, additional, Gomez-Muñoz, Antonio, additional, Suárez-Cabrera, Cristian, additional, Lodewijk, Iris, additional, Flores, Juana M., additional, Sutherland, James D., additional, Barrio, Rosa, additional, de Bono, Johann S., additional, Paramio, Jesús M., additional, Trka, Jan, additional, Graupera, Mariona, additional, Gomis, Roger R., additional, and Carracedo, Arkaitz, additional more...
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- 2020
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32. El Derecho como sistema normativo institucional
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Martín Martín, Natalia, Marcano Buénaga, Enrique, and Universidad de Valladolid. Facultad de Derecho
- Subjects
Sistema normativo ,Derecho ,Kelsen, Hans ,Filosofía ,Hart, H. L. A - Abstract
El Derecho como sistema normativo se define como un conjunto de enunciados normativos que comprende consecuencias lógicas. Hay al menos una norma que se correlaciona a un caso determinado con una solución normativa. Por ello, se considera como características la coactividad y la institucionalización. En este trabajo, nos centramos en esta característica. Decir que el Derecho como sistema normativo es institucional supone la existencia de órganos centralizados para aplicar medidas coactivas; el sistema jurídico no sólo regula el empleo de la fuerza, sino que regula como un monopolio ciertos órganos. A estos órganos se les llama órganos primarios del sistema jurídico. Estos órganos primarios son tres principalmente: los encargados de crear y derogar normas generales del sistema (legisladores); los encargados de determinar qué normas son aplicables a situaciones particulares y de disponer la ejecución de las medidas coactivas que en tales normas prescriben (jueces y tribunales); y los órganos que ejecutan físicamente las medidas coactivas (policía y otros órganos de seguridad)., Grado en Derecho more...
- Published
- 2018
33. Low-dose statin treatment increases prostate cancer aggressiveness
- Author
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Caro-Maldonado, Alfredo, Camacho, Laura, Zabala-Letona, Amaia, Torrano, Verónica, Fernández Ruiz, Sonia, Zamacola-Bascaran, Kepa, Arreal, Leire, Valcárcel-Jiménez, Lorea, Martín-Martín, Natalia, Flores, Juana M., Cortazar, Ana Rosa, Zúñiga-García, Patricia, Arruabarrena-Aristorena, Amaia, Guillaumond, Fabienne, Cabrera, Diana, Falcón-Perez, Juan M., Aransay, Ana M., Gomez Muñoz, Antonio, Olivan, M., Morote Robles, Juan, Carracedo, Arkaitz, Universitat Autònoma de Barcelona, Centre de Recherche en Cancérologie de Marseille (CRCM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, and Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) more...
- Subjects
0301 basic medicine ,Oncology ,medicine.medical_specialty ,obesity ,[SDV]Life Sciences [q-bio] ,Disease ,Mouse models ,statins ,03 medical and health sciences ,chemistry.chemical_compound ,Prostate cancer ,0302 clinical medicine ,Internal medicine ,Diabetes mellitus ,prostate cancer ,cholesterol ,mouse models ,medicine ,Obesity ,Càncer de pròstata ,Cholesterol ,business.industry ,Statins ,Cancer ,medicine.disease ,3. Good health ,030104 developmental biology ,chemistry ,Simvastatin ,030220 oncology & carcinogenesis ,Cancer cell ,Obesitat ,Metabolic syndrome ,business ,Colesterol ,medicine.drug ,Priority Research Paper - Abstract
Altres ajuts: NM-M was supported by the Spanish Association Against Cancer (AECC), AECC JP Vizcaya. VT is supported by Fundación Vasca de Innovación e Investigación Sanitarias, BIOEF (BIO15/CA/052), the department of health of the Basque Government (2016111109) and the 2016 grant of the AECC (Junta provincial de Bizkaia). LA, AA-A and LV-J were supported by the Basque Government of education. The work of A.C. is supported by the Ramón y Cajal award, the Basque Department of Industry, Tourism and Trade (Etortek) and the department of education (IKERTALDE IT1106-16), FERO VIII Fellowship, the BBVA foundation, Severo Ochoa. Excellence Accreditation SEV-2016-0644) and the European Research Council (Starting Grant 336343; Proof of Concept 754627). The participation of AC, VT, NM-M, SF and AZ as part of CIBERONC was co-funded with FEDER funds. Prostate cancer is diagnosed late in life, when co-morbidities are frequent. Among them, hypertension, hypercholesterolemia, diabetes or metabolic syndrome exhibit an elevated incidence. In turn, prostate cancer patients frequently undergo chronic pharmacological treatments that could alter disease initiation, progression and therapy response. Here we show that treatment with anti-cholesterolemic drugs, statins, at doses achieved in patients, enhance the pro-tumorigenic activity of obesogenic diets. In addition, the use of a mouse model of prostate cancer and human prostate cancer xenografts revealed that in vivo simvastatin administration alone increases prostate cancer aggressiveness. In vitro cell line systems supported the notion that this phenomenon occurs, at least in part, through the direct action on cancer cells of low doses of statins, in range of what is observed in human plasma. In sum, our results reveal a prostate cancer experimental system where statins exhibit an undesirable effect, and warrant further research to address the relevance and implications of this observation in human prostate cancer. more...
- Published
- 2018
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34. PGC1α Suppresses Prostate Cancer Cell Invasion through ERRα Transcriptional Control
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Valcarcel-Jimenez, Lorea, primary, Macchia, Alice, additional, Crosas-Molist, Eva, additional, Schaub-Clerigué, Ariane, additional, Camacho, Laura, additional, Martín-Martín, Natalia, additional, Cicogna, Paolo, additional, Viera-Bardón, Cristina, additional, Fernández-Ruiz, Sonia, additional, Rodriguez-Hernandez, Irene, additional, Hermanova, Ivana, additional, Astobiza, Ianire, additional, Cortazar, Ana R., additional, Corres-Mendizabal, Jon, additional, Gomez-Muñoz, Antonio, additional, Sanz-Moreno, Victoria, additional, Torrano, Verónica, additional, and Carracedo, Arkaitz, additional more...
- Published
- 2019
- Full Text
- View/download PDF
35. LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is altered in Townes-Brocks Syndrome
- Author
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Bozal-Basterra, Laura, primary, Gonzalez-Santamarta, María, additional, Bermejo-Arteagabeitia, Aitor, additional, Da Fonseca, Carolina, additional, Pampliega, Olatz, additional, Andrade, Ricardo, additional, Martín-Martín, Natalia, additional, Branon, Tess C, additional, Ting, Alice Y, additional, Carracedo, Arkaitz, additional, Rodríguez, Jose A., additional, Elortza, Felix, additional, Sutherland, James D., additional, and Barrio, Rosa, additional more...
- Published
- 2019
- Full Text
- View/download PDF
36. Integrative Analysis of Transcriptomics and Clinical Data Uncovers the Tumor- Suppressive Activity of MITF in Prostate Cancer
- Author
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Bioquímica y biología molecular, Cirugía, radiología y medicina física, Biokimika eta biologia molekularra, Kirurgia,erradiologia eta medikuntza fisikoa, Valcárcel Jiménez, Lorea, Macchia, Alice, Martín Martín, Natalia, Cortazar, Ana Rosa, Schaub Clerigué, Ariane, Pujana Vaquerizo, Mikel, Fernández Ruiz, Sonia, Lacasa Viscasillas, Isabel, Santos Martín, Aida, Loizaga Iriarte, Ana, Unda Urzaiz, Jesús Miguel, Hermanova, Ivana, Astobiza Pérez, Janire, Graupera, Mariona, Julia, Starkova, Sutherland, James D., Barrio Olano, María Rosa, Aransay Bañares, Ana María, Carracedo Pérez, Arkaitz, Torrano Moya, Verónica, Bioquímica y biología molecular, Cirugía, radiología y medicina física, Biokimika eta biologia molekularra, Kirurgia,erradiologia eta medikuntza fisikoa, Valcárcel Jiménez, Lorea, Macchia, Alice, Martín Martín, Natalia, Cortazar, Ana Rosa, Schaub Clerigué, Ariane, Pujana Vaquerizo, Mikel, Fernández Ruiz, Sonia, Lacasa Viscasillas, Isabel, Santos Martín, Aida, Loizaga Iriarte, Ana, Unda Urzaiz, Jesús Miguel, Hermanova, Ivana, Astobiza Pérez, Janire, Graupera, Mariona, Julia, Starkova, Sutherland, James D., Barrio Olano, María Rosa, Aransay Bañares, Ana María, Carracedo Pérez, Arkaitz, and Torrano Moya, Verónica more...
- Abstract
The dysregulation of gene expression is an enabling hallmark of cancer. Computational analysis of transcriptomics data from human cancer specimens, complemented with exhaustive clinical annotation, provides an opportunity to identify core regulators of the tumorigenic process. Here we exploit well-annotated clinical datasets of prostate cancer for the discovery of transcriptional regulators relevant to prostate cancer. Following this rationale, we identify Microphthalmia-associated transcription factor (MITF) as a prostate tumor suppressor among a subset of transcription factors. Importantly, we further interrogate transcriptomics and clinical data to refine MITF perturbation-based empirical assays and unveil Crystallin Alpha B (CRYAB) as an unprecedented direct target of the transcription factor that is, at least in part, responsible for its tumor-suppressive activity in prostate cancer. This evidence was supported by the enhanced prognostic potential of a signature based on the concomitant alteration of MITF and CRYAB in prostate cancer patients. In sum, our study provides proof-of-concept evidence of the potential of the bioinformatics screen of publicly available cancer patient databases as discovery platforms, and demonstrates that the MITF-CRYAB axis controls prostate cancer biology. more...
- Published
- 2018
37. Cancertool: A visualization and representation interface to exploit cancer datasets
- Author
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Fundación Vasca de Innovación e Investigación Sanitarias, Diputación Foral de Bizkaia, BBVA, European Commission, Ministerio de Economía y Competitividad (España), Eusko Jaurlaritza, Junta de Castilla y León, Worldwide Cancer Research, Fundación Ramón Areces, Cortázar, Ana R., Torrano, Verónica, Martín-Martín, Natalia, Caro-Maldonado, Alfredo, Camacho, Laura, Hermanova, Ivana, Guruceaga, Elizabeth, Lorenzo-Martín, L. Francisco, Caloto, Rubén, Gomis, Roger R., Apaolaza, Iñigo, Quesada, Víctor, Trka, Jan, Gómez-Muñoz, Antonio, Vincent, Silvestre, Bustelo, Xosé R., Planes, Francisco J., Aransay, Ana M., Carracedo, Arkaitz, Fundación Vasca de Innovación e Investigación Sanitarias, Diputación Foral de Bizkaia, BBVA, European Commission, Ministerio de Economía y Competitividad (España), Eusko Jaurlaritza, Junta de Castilla y León, Worldwide Cancer Research, Fundación Ramón Areces, Cortázar, Ana R., Torrano, Verónica, Martín-Martín, Natalia, Caro-Maldonado, Alfredo, Camacho, Laura, Hermanova, Ivana, Guruceaga, Elizabeth, Lorenzo-Martín, L. Francisco, Caloto, Rubén, Gomis, Roger R., Apaolaza, Iñigo, Quesada, Víctor, Trka, Jan, Gómez-Muñoz, Antonio, Vincent, Silvestre, Bustelo, Xosé R., Planes, Francisco J., Aransay, Ana M., and Carracedo, Arkaitz more...
- Abstract
With the advent of OMICs technologies, both individual research groups and consortia have spear-headed the characterization of human samples of multiple pathophysiologic origins, resulting in thousands of archived genomes and transcriptomes. Although a variety of web tools are now available to extract information from OMICs data, their utility has been limited by the capacity of nonbioinformatician researchers to exploit the information. To address this problem, we have developed CANCERTOOL, a web-based interface that aims to overcome the major limitations of public transcriptomics dataset analysis for highly prevalent types of cancer (breast, prostate, lung, and colorectal). CANCERTOOL provides rapid and comprehensive visualization of gene expression data for the gene(s) of interest in well-annotated cancer datasets. This visualization is accompanied by generation of reports customized to the interest of the researcher (e.g., editable figures, detailed statistical analyses, and access to raw data for reanalysis). It also carries out gene-to-gene correlations in multiple datasets at the same time or using preset patient groups. Finally, this new tool solves the time-consuming task of performing functional enrichment analysis with gene sets of interest using up to 11 different databases at the same time. Collectively, CANCERTOOL represents a simple and freely accessible interface to interrogate well-annotated datasets and obtain publishable representations that can contribute to refinement and guidance of cancer-related investigations at all levels of hypotheses and design. more...
- Published
- 2018
38. CANCERTOOL: A Visualization and Representation Interface to Exploit Cancer Datasets
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Cortazar, Ana R., primary, Torrano, Veronica, additional, Martín-Martín, Natalia, additional, Caro-Maldonado, Alfredo, additional, Camacho, Laura, additional, Hermanova, Ivana, additional, Guruceaga, Elizabeth, additional, Lorenzo-Martín, Luis F., additional, Caloto, Ruben, additional, Gomis, Roger R., additional, Apaolaza, Iñigo, additional, Quesada, Victor, additional, Trka, Jan, additional, Gomez-Muñoz, Antonio, additional, Vincent, Silvestre, additional, Bustelo, Xose R., additional, Planes, Francisco J., additional, Aransay, Ana M., additional, and Carracedo, Arkaitz, additional more...
- Published
- 2018
- Full Text
- View/download PDF
39. Integrative analysis of transcriptomic and clinical data uncovers the tumor suppressive activity of MITF in prostate cancer
- Author
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Valcarcel-Jimenez, Lorea, primary, Macchia, Alice, additional, Martín-Martín, Natalia, additional, Cortazar, Ana Rosa, additional, Schaub-Clerigué, Ariane, additional, Pujana-Vaquerizo, Mikel, additional, Fernández-Ruiz, Sonia, additional, Lacasa-Viscasillas, Isabel, additional, Santos-Martin, Aida, additional, Loizaga-Iriarte, Ana, additional, Unda-Urzaiz, Miguel, additional, Hermanova, Ivana, additional, Astobiza, lanire, additional, Graupera, Mariona, additional, Starkova, Julia, additional, Sutherland, James, additional, Barrio, Rosa, additional, Aransay, Ana M., additional, Carracedo, Arkaitz, additional, and Torrano, Verónica, additional more...
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- 2018
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40. Erratum: Corrigendum: mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer
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Zabala-Letona, Amaia, primary, Arruabarrena-Aristorena, Amaia, additional, Martín-Martín, Natalia, additional, Fernandez-Ruiz, Sonia, additional, Sutherland, James D., additional, Clasquin, Michelle, additional, Tomas-Cortazar, Julen, additional, Jimenez, Jose, additional, Torres, Ines, additional, Quang, Phong, additional, Ximenez-Embun, Pilar, additional, Bago, Ruzica, additional, Ugalde-Olano, Aitziber, additional, Loizaga-Iriarte, Ana, additional, Lacasa-Viscasillas, Isabel, additional, Unda, Miguel, additional, Torrano, Verónica, additional, Cabrera, Diana, additional, van Liempd, Sebastiaan M., additional, Cendon, Ylenia, additional, Castro, Elena, additional, Murray, Stuart, additional, Revandkar, Ajinkya, additional, Alimonti, Andrea, additional, Zhang, Yinan, additional, Barnett, Amelia, additional, Lein, Gina, additional, Pirman, David, additional, Cortazar, Ana R., additional, Arreal, Leire, additional, Prudkin, Ludmila, additional, Astobiza, Ianire, additional, Valcarcel-Jimenez, Lorea, additional, Zuñiga-García, Patricia, additional, Fernandez-Dominguez, Itziar, additional, Piva, Marco, additional, Caro-Maldonado, Alfredo, additional, Sánchez-Mosquera, Pilar, additional, Castillo-Martín, Mireia, additional, Serra, Violeta, additional, Beraza, Naiara, additional, Gentilella, Antonio, additional, Thomas, George, additional, Azkargorta, Mikel, additional, Elortza, Felix, additional, Farràs, Rosa, additional, Olmos, David, additional, Efeyan, Alejo, additional, Anguita, Juan, additional, Muñoz, Javier, additional, Falcón-Pérez, Juan M., additional, Barrio, Rosa, additional, Macarulla, Teresa, additional, Mato, Jose M., additional, Martinez-Chantar, Maria L., additional, Cordon-Cardo, Carlos, additional, Aransay, Ana M., additional, Marks, Kevin, additional, Baselga, José, additional, Tabernero, Josep, additional, Nuciforo, Paolo, additional, Manning, Brendan D., additional, Marjon, Katya, additional, and Carracedo, Arkaitz, additional more...
- Published
- 2018
- Full Text
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41. PPARδ Elicits Ligand-Independent Repression of Trefoil Factor Family to Limit Prostate Cancer Growth
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Martín-Martín, Natalia, primary, Zabala-Letona, Amaia, additional, Fernández-Ruiz, Sonia, additional, Arreal, Leire, additional, Camacho, Laura, additional, Castillo-Martin, Mireia, additional, Cortazar, Ana R., additional, Torrano, Verónica, additional, Astobiza, Ianire, additional, Zúñiga-García, Patricia, additional, Ugalde-Olano, Aitziber, additional, Loizaga-Iriarte, Ana, additional, Unda, Miguel, additional, Valcárcel-Jiménez, Lorea, additional, Arruabarrena-Aristorena, Amaia, additional, Piva, Marco, additional, Sánchez-Mosquera, Pilar, additional, Aransay, Ana M., additional, Gomez-Muñoz, Antonio, additional, Barrio, Rosa, additional, Sutherland, James D., additional, and Carracedo, Arkaitz, additional more...
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- 2018
- Full Text
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42. Metabolism and Transcription in Cancer: Merging Two Classic Tales
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Martín-Martín, Natalia, primary, Carracedo, Arkaitz, additional, and Torrano, Verónica, additional
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- 2018
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43. Low-dose statin treatment increases prostate cancer aggressiveness
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Caro-Maldonado, Alfredo, primary, Camacho, Laura, additional, Zabala-Letona, Amaia, additional, Torrano, Verónica, additional, Fernández-Ruiz, Sonia, additional, Zamacola-Bascaran, Kepa, additional, Arreal, Leire, additional, Valcárcel-Jiménez, Lorea, additional, Martín-Martín, Natalia, additional, Flores, Juana M., additional, Cortazar, Ana R., additional, Zúñiga-García, Patricia, additional, Arruabarrena-Aristorena, Amaia, additional, Guillaumond, Fabienne, additional, Cabrera, Diana, additional, Falcón-Perez, Juan M., additional, Aransay, Ana M., additional, Gomez-Muñoz, Antonio, additional, Olivan, Mireia, additional, Morote, Juan, additional, and Carracedo, Arkaitz, additional more...
- Published
- 2017
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44. Erratum: The metabolic co-regulator PGC1α suppresses prostate cancer metastasis
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Torrano, Veronica, primary, Valcarcel-Jimenez, Lorea, additional, Cortazar, Ana Rosa, additional, Liu, Xiaojing, additional, Urosevic, Jelena, additional, Castillo-Martin, Mireia, additional, Fernández-Ruiz, Sonia, additional, Morciano, Giampaolo, additional, Caro-Maldonado, Alfredo, additional, Guiu, Marc, additional, Zúñiga-García, Patricia, additional, Graupera, Mariona, additional, Bellmunt, Anna, additional, Pandya, Pahini, additional, Lorente, Mar, additional, Martín-Martín, Natalia, additional, Sutherland, James David, additional, Sanchez-Mosquera, Pilar, additional, Bozal-Basterra, Laura, additional, Zabala-Letona, Amaia, additional, Arruabarrena-Aristorena, Amaia, additional, Berenguer, Antonio, additional, Embade, Nieves, additional, Ugalde-Olano, Aitziber, additional, Lacasa-Viscasillas, Isabel, additional, Loizaga-Iriarte, Ana, additional, Unda-Urzaiz, Miguel, additional, Schultz, Nikolaus, additional, Aransay, Ana Maria, additional, Sanz-Moreno, Victoria, additional, Barrio, Rosa, additional, Velasco, Guillermo, additional, Pinton, Paolo, additional, Cordon-Cardo, Carlos, additional, Locasale, Jason W., additional, Gomis, Roger R., additional, and Carracedo, Arkaitz, additional more...
- Published
- 2017
- Full Text
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45. mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer
- Author
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Zabala-Letona, Amaia, primary, Arruabarrena-Aristorena, Amaia, additional, Martín-Martín, Natalia, additional, Fernandez-Ruiz, Sonia, additional, Sutherland, James D., additional, Clasquin, Michelle, additional, Tomas-Cortazar, Julen, additional, Jimenez, Jose, additional, Torres, Ines, additional, Quang, Phong, additional, Ximenez-Embun, Pilar, additional, Bago, Ruzica, additional, Ugalde-Olano, Aitziber, additional, Loizaga-Iriarte, Ana, additional, Lacasa-Viscasillas, Isabel, additional, Unda, Miguel, additional, Torrano, Verónica, additional, Cabrera, Diana, additional, van Liempd, Sebastiaan M., additional, Cendon, Ylenia, additional, Castro, Elena, additional, Murray, Stuart, additional, Revandkar, Ajinkya, additional, Alimonti, Andrea, additional, Zhang, Yinan, additional, Barnett, Amelia, additional, Lein, Gina, additional, Pirman, David, additional, Cortazar, Ana R., additional, Arreal, Leire, additional, Prudkin, Ludmila, additional, Astobiza, Ianire, additional, Valcarcel-Jimenez, Lorea, additional, Zuñiga-García, Patricia, additional, Fernandez-Dominguez, Itziar, additional, Piva, Marco, additional, Caro-Maldonado, Alfredo, additional, Sánchez-Mosquera, Pilar, additional, Castillo-Martín, Mireia, additional, Serra, Violeta, additional, Beraza, Naiara, additional, Gentilella, Antonio, additional, Thomas, George, additional, Azkargorta, Mikel, additional, Elortza, Felix, additional, Farràs, Rosa, additional, Olmos, David, additional, Efeyan, Alejo, additional, Anguita, Juan, additional, Muñoz, Javier, additional, Falcón-Pérez, Juan M., additional, Barrio, Rosa, additional, Macarulla, Teresa, additional, Mato, Jose M., additional, Martinez-Chantar, Maria L., additional, Cordon-Cardo, Carlos, additional, Aransay, Ana M., additional, Marks, Kevin, additional, Baselga, José, additional, Tabernero, Josep, additional, Nuciforo, Paolo, additional, Manning, Brendan D., additional, Marjon, Katya, additional, and Carracedo, Arkaitz, additional more...
- Published
- 2017
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46. Identification of treatments targeting PMLexpressing breast cancers
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Carracedo Pérez, Arkaitz, Martín Martín, Natalia, F. CIENCIA Y TECNOLOGIA, ZIENTZIA ETA TEKNOLOGIA F., Grado en Bioquímica y Biología Molecular, Biokimikako eta Biologia Molekularreko Gradua, Insausti Urkia, Naroa, Carracedo Pérez, Arkaitz, Martín Martín, Natalia, F. CIENCIA Y TECNOLOGIA, ZIENTZIA ETA TEKNOLOGIA F., Grado en Bioquímica y Biología Molecular, Biokimikako eta Biologia Molekularreko Gradua, and Insausti Urkia, Naroa more...
- Abstract
The main aim of this project is to find a suitable ATO concentration to combine with already approved chemotherapeutic agents to find that synergistic effect in triple negative breast cancer MDA-MB 231 cell line, as a new strategy to treat the disease. more...
- Published
- 2016
47. Stratification and therapeutic potential of PML in metastatic breast cancer
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Martín-Martín, Natalia, primary, Piva, Marco, additional, Urosevic, Jelena, additional, Aldaz, Paula, additional, Sutherland, James D., additional, Fernández-Ruiz, Sonia, additional, Arreal, Leire, additional, Torrano, Verónica, additional, Cortazar, Ana R., additional, Planet, Evarist, additional, Guiu, Marc, additional, Radosevic-Robin, Nina, additional, Garcia, Stephane, additional, Macías, Iratxe, additional, Salvador, Fernando, additional, Domenici, Giacomo, additional, Rueda, Oscar M., additional, Zabala-Letona, Amaia, additional, Arruabarrena-Aristorena, Amaia, additional, Zúñiga-García, Patricia, additional, Caro-Maldonado, Alfredo, additional, Valcárcel-Jiménez, Lorea, additional, Sánchez-Mosquera, Pilar, additional, Varela-Rey, Marta, additional, Martínez-Chantar, Maria Luz, additional, Anguita, Juan, additional, Ibrahim, Yasir H., additional, Scaltriti, Maurizio, additional, Lawrie, Charles H., additional, Aransay, Ana M., additional, Iovanna, Juan L., additional, Baselga, Jose, additional, Caldas, Carlos, additional, Barrio, Rosa, additional, Serra, Violeta, additional, dM Vivanco, Maria, additional, Matheu, Ander, additional, Gomis, Roger R., additional, and Carracedo, Arkaitz, additional more...
- Published
- 2016
- Full Text
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48. Transcriptomic profiling of urine extracellular vesicles reveals alterations of CDH3 in prostate cancer
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Royo, Felix, primary, Zuñiga-Garcia, Patricia, additional, Torrano, Verónica, additional, Loizaga, Ana, additional, Sanchez-Mosquera, Pilar, additional, Ugalde-Olano, Aitziber, additional, González, Esperanza, additional, Cortazar, Ana R., additional, Palomo, Laura, additional, Fernández-Ruiz, Sonia, additional, Lacasa-Viscasillas, Isabel, additional, Berdasco, Maria, additional, Sutherland, James D., additional, Barrio, Rosa, additional, Zabala-Letona, Amaia, additional, Martín-Martín, Natalia, additional, Arruabarrena-Aristorena, Amaia, additional, Valcarcel-Jimenez, Lorea, additional, Caro-Maldonado, Alfredo, additional, Gonzalez-Tampan, Jorge, additional, Cachi-Fuentes, Guido, additional, Esteller, Manel, additional, Aransay, Ana M., additional, Unda, Miguel, additional, Falcón-Pérez, Juan M., additional, and Carracedo, Arkaitz, additional more...
- Published
- 2016
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49. Methodological aspects of the molecular and histological study of prostate cancer: Focus on PTEN
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Ugalde-Olano, Aitziber, primary, Egia, Ainara, additional, Fernández-Ruiz, Sonia, additional, Loizaga-Iriarte, Ana, additional, Zuñiga-García, Patricia, additional, Garcia, Stephane, additional, Royo, Félix, additional, Lacasa-Viscasillas, Isabel, additional, Castro, Erika, additional, Cortazar, Ana R., additional, Zabala-Letona, Amaia, additional, Martín-Martín, Natalia, additional, Arruabarrena-Aristorena, Amaia, additional, Torrano-Moya, Verónica, additional, Valcárcel-Jiménez, Lorea, additional, Sánchez-Mosquera, Pilar, additional, Caro-Maldonado, Alfredo, additional, González-Tampan, Jorge, additional, Cachi-Fuentes, Guido, additional, Bilbao, Elena, additional, Montero, Rocío, additional, Fernández, Sara, additional, Arrieta, Edurne, additional, Zorroza, Kerman, additional, Castillo-Martín, Mireia, additional, Serra, Violeta, additional, Salazar, Eider, additional, Macías-Cámara, Nuria, additional, Tabernero, Jose, additional, Baselga, Jose, additional, Cordón-Cardo, Carlos, additional, Aransay, Ana M., additional, Villar, Amaia Del, additional, Iovanna, Juan L., additional, Falcón-Pérez, Juan M., additional, Unda, Miguel, additional, Bilbao, Roberto, additional, and Carracedo, Arkaitz, additional more...
- Published
- 2015
- Full Text
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50. The Promyelocytic Leukemia Protein Is Upregulated in Conditions of Obesity and Liver Steatosis
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Carracedo, Arkaitz, primary, Rousseau, Déborah, additional, Douris, Nicholas, additional, Fernández-Ruiz, Sonia, additional, Martín-Martín, Natalia, additional, Weiss, Dror, additional, Webster, Kaitlyn, additional, Adams, Andrew C., additional, Vazquez-Chantada, Mercedes, additional, Martinez-Chantar, Maria L., additional, Anty, Rodolphe, additional, Tran, Albert, additional, Maratos-Flier, Eleftheria, additional, Gual, Philippe, additional, and Pandolfi, Pier Paolo, additional more...
- Published
- 2015
- Full Text
- View/download PDF
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