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4. Fatal granulomatous amoebic encephalitis due to free‐living amoebae in two boys in two different hospitals in Lima, Perú

Author

Cabello‐Vílchez, Alfonso Martín, primary, Chura‐Araujo, Miguel A., additional, Anicama Lima, William E., additional, Vela, César, additional, Asencio, Angélica Y., additional, García, Hugo, additional, Carmen Garaycochea, María, additional, Náquira, César, additional, Rojas, Elvis, additional, and Martínez, Dalila Y., additional

Published
2019
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5. Fatal granulomatous amoebic encephalitis due to free‐living amoebae in two boys in two different hospitals in Lima, Perú.

Author

Cabello‐Vílchez, Alfonso Martín, Chura‐Araujo, Miguel A., Anicama Lima, William E., Vela, César, Asencio, Angélica Y., García, Hugo, Carmen Garaycochea, María, Náquira, César, Rojas, Elvis, and Martínez, Dalila Y.

Subjects
ENCEPHALITIS, AMOEBA, SYMPTOMS, ACANTHAMOEBA, SWIMMING pools, MYCOBACTERIUM avium paratuberculosis, JAPANESE encephalitis viruses
Abstract

Granulomatous amoebic encephalitis caused by free‐living amoebae is a rare condition that is difficult to diagnose and hard to treat, generally being fatal. Anti‐amoebic treatment is often delayed because clinical signs and symptoms may hide the probable causing agent misleading the appropriate diagnostic test. There are four genera of free‐living amoeba associated with human infection, Naegleria, Acanthamoeba sp., Balamuthia and Sappinia. Two boys were admitted with diagnosis of acute encephalitis. The history of having been in contact with swimming pools and rivers, supports the suspicion of an infection due to free‐living amoebae. In both cases a brain biopsy was done, the histology confirmed granulomatous amoebic encephalitis with the presence of amoebic trophozoites. [ABSTRACT FROM AUTHOR]

Published
2020
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8. Successful Treatment of Balamuthia mandrillaris Amoebic Infection with Extensive Neurological and Cutaneous Involvement.

Author

Martínez, Dalila Y., Seas, Carlos, Bravo, Francisco, Legua, Pedro, Ramos, Cesar, Cabello, Alfonso M., and Gotuzzo, Eduardo

Subjects
*ENCEPHALITIS, *AMOEBA, *WOMEN patients, *PATHOGENIC microorganisms, *CUTANEOUS manifestations of general diseases, *NEUROLOGIC manifestations of general diseases, *ALBENDAZOLE, *AMPHOTERICIN B, *MACROLIDE antibiotics
Abstract

Granulomatous amoebic encephalitis caused by Balamuthia mandrillaris is an uncommon infection for which there is no optimal therapy. We describe a young, female patient who presented with extensive cutaneous and neurological involvement and who recovered after receiving prolonged treatment with miltefosine, fluconazole, and albendazole. [ABSTRACT FROM AUTHOR]

Published
2010
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