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3. Pediatric Emergency Department Management of C1 Inhibitor Deficiency

Author

María Teresa Caballero Molina, María de la Calle, María Pedrosa Delgado, Marta Plata Gallardo, and Paula García Sánchez

Subjects
Male, Pediatrics, medicine.medical_specialty, C1 inhibitor deficiency, MEDLINE, Disease, C1-inhibitor, medicine, Humans, Angioedema, Child, Retrospective Studies, biology, business.industry, Angioedemas, Hereditary, Retrospective cohort study, General Medicine, Emergency department, Hospitalization, Pediatrics, Perinatology and Child Health, Emergency Medicine, biology.protein, medicine.symptom, Emergency Service, Hospital, business, Rare disease
Abstract

Introduction C1 inhibitor deficiency is a rare, potentially life-threatening syndrome. Acute attacks of angioedema may occur at any time, so the emergency department (ED) constitutes an indispensable component of its care. Aim To describe the reasons for consultation by children with C1 inhibitor deficiency at the ED, as well as its management and complications. Patients and methods This is a longitudinal retrospective study conducted in a pediatric ED of a tertiary care hospital in Madrid. The study includes children with C1 inhibitor deficiency, aged 0 to 16 years, who had consulted the ED for whatever reason, over a span of 9 years (2011-2020). Analyzed data include the following: age, sex, type of disease, reason for query, complementary examinations, established diagnosis, treatment, number of visits to the ED, length of ED stay, and admissions. Results Sixteen patients, amounting a total of 83 ED visits, were analyzed. Fifty-six percent were boys, and the median age was 6.9 years (5 months to 15.9 years). The median and mean of number of visits to the ED per patient was 2 (1-22) and 5.2 ± 6.11, respectively. There were 85.5% of the ED visits initially attributed to acute angioedema attacks. Additional tests were conducted in 30.1%, and 31.3% required C1 inhibitor concentrate. Three episodes required hospital admission (3.6%), and there were no complications. The stay in the ED was longer for patients who needed specific intravenous treatment. Conclusions C1 inhibitor deficiency is a rare disease that may require ED care. The main reasons for ED visits were respiratory problems, and the main location of the acute attacks of angioedema were abdominal and cutaneous. Almost one third of the ED visits needed specific treatment, resulting in longer stays. A proper management in the ED and the specific treatment with C1 inhibitor concentrate were effective in 96.2% of the acute attacks of angioedema. Knowledge of this disease in the ED is key to prevent complications.

Published
2021
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4. Comparison between patients attended in the emergency department of a tertiary hospital in Madrid in the first and second wave of coronavirus SARS-COV-2 pandemic

Author

Cristina de Miguel Cáceres, Marta Bueno Barriocanal, María de la Calle, Marta Plata Gallardo, and Irene Martín Espín

Subjects
2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Emergency department, medicine.disease, Pediatrics, RJ1-570, Management of Technology and Innovation, Pandemic, Medicine, Severe acute respiratory syndrome coronavirus, Medical emergency, business, Scientific Letter
Published
2021
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5. Comparación entre la primera y la segunda ola de la pandemia producida por el coronavirus SARS-CoV-2 en urgencias pediátricas de un hospital terciario de Madrid

Author

Cristina de Miguel Cáceres, Marta Plata Gallardo, Marta Bueno Barriocanal, María de la Calle, and Irene Martín Espín

Subjects
2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Emergency department, Virology, Pediatrics, Article, RJ1-570, Pediatrics, Perinatology and Child Health, Pandemic, Medicine, Severe acute respiratory syndrome coronavirus, business
Published
2021

6. Collateral damage in pediatric scenarios requiring urgent care during the COVID-19 pandemic

Author

José Antonio, Ruiz Domínguez, Miguel Ángel, Molina Gutiérrez, Cristina, de Miguel Cáceres, Irene, Martín Espín, Marta, Plata Gallardo, and Julia, Martín Sánchez

Subjects
Adolescent, SARS-CoV-2, Infant, Newborn, COVID-19, Infant, Appendicitis, Ambulatory Care Facilities, Time-to-Treatment, Hospitals, University, Fractures, Bone, Diabetes Mellitus, Type 1, Spain, Child, Preschool, Urinary Tract Infections, Ambulatory Care, Humans, Emergencies, Hyperbilirubinemia, Neonatal, Triage, Child, Pandemics, Diagnosis-Related Groups, Retrospective Studies
Published
2021

7. Diagnostic Accuracy of the Panbio Severe Acute Respiratory Syndrome Coronavirus 2 Antigen Rapid Test Compared with Reverse-Transcriptase Polymerase Chain Reaction Testing of Nasopharyngeal Samples in the Pediatric Population

Author

Serena Villaverde, Sara Domínguez-Rodríguez, Gema Sabrido, Conchita Pérez-Jorge, Marta Plata, María Pilar Romero, Carlos Daniel Grasa, Ana Belén Jiménez, Elena Heras, Antonio Broncano, María del Mar Núñez, Marta Illán, Paloma Merino, Beatriz Soto, David Molina-Arana, Amanda Bermejo, Pablo Mendoza, Manuel Gijón, Begoña Pérez-Moneo, Cinta Moraleda, Alfredo Tagarro, Cristina Calvo, Ma José Mellado, Paula Rodríguez-Molino, Teresa del Rosal, Mar Santos, Marisa Navarro, Elena Rincón, Begoña Santiago, Jesús Saavedra-Lozano, David Aguilera-Alonso, Cristina Epalza, Daniel Blázquez-Gamero, Sara Villanueva, Pablo Rojo, Gero Calleja, J.A. Alonso, Mercedes de la Torre, F.J. Sanz-Santaeufemia, M.I. Iglesias, B. Herrero, M. Alonso, Toni Soriano-Arandes, J.M. Pujol, Susana Melendo, Pere Soler-Palacin, Silvia Simó, Victoria Fumadó, Miguel Lanaspa, M. Urretavizcaya, Mercedes Herranz, Marta Pareja, Fatima Ara, Santiago Cabañas, Rut del Valle, Ana Barrios, Enrique Otheo, José Luis Vázquez, Lola Falcón, Olaf Neth, Peter Olbrich, Walter Goicoechea, Laura Martín, Lucía Figueroa, María Llorente, María Penin, Claudia García, María García, Teresa Alvaredo, Ma Inmaculada Olmedo, Agustín López, Elvira Cobo, Mariam Tovizi, Pilar Galán, Sara Guillén, Adriana Navas, M. Luz García, Sara Pérez, María José Hernández, Arantxa Berzosa, Nerea Gallego, Ana López, Beatriz Ruiz, Santiago Alfayate, Ana Menasalvas, Eloísa Cervantes, María Méndez, Ángela Hurtado, Yolanda Ruiz, Cristina García, Inés Amich, Manuel Oltra, Álvaro Villaroya, Angustias Ocaña, Isabel Romero, María Fernanda Guzmán, M.J. Pascual, María Sánchez-Códez, Elena Montesinos, Julia Jensen, María Rodríguez, Gloria Caro, Neus Rius, Alba Gómez, Rafael Bretón, Margarita Rodríguez, Julio Romero, Ana Campos, Mercedes García, Rosa María Velasco, Zulema Lobato, Fernando Centeno, Elena Pérez, Paula Vidal, Corsino Rey, Ana Vivanco, Maruchi Alonso, Pedro Alcalá, Javier González de Dios, Eduard Solé, Laura Minguell, Itziar Astigarraga, Ma Ángeles Vázquez, Miguel Sánchez, Elena Díaz, Eduardo Consuegra, María Cabanillas, Luis Peña, Elisa Garrote, Maite Goicoechea, Irene Centelles, Santiago Lapeña, Sara Gutiérrez, Soraya Gutiérrez, Amparo Cavalle, José María Olmos, Alejandro Cobo, Sara Díaz, Beatriz Jiménez, Raúl González, Miguel Lafuente, Matilde Bustillo, Natividad Pons, Julia Morata, and Elsa Segura

Subjects
Male, medicine.medical_specialty, Adolescent, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Diagnostic accuracy, Disease, medicine.disease_cause, Gastroenterology, law.invention, antigen test, 03 medical and health sciences, 0302 clinical medicine, Antigen, law, 030225 pediatrics, Internal medicine, Nasopharynx, medicine, Humans, 030212 general & internal medicine, Pediatrics, Perinatology, and Child Health, Child, Antigens, Viral, Pandemics, Polymerase chain reaction, Coronavirus, business.industry, Reverse Transcriptase Polymerase Chain Reaction, SARS-CoV-2, Infant, Newborn, COVID-19, Infant, Reproducibility of Results, Reverse transcriptase, PCR, Child, Preschool, Pediatrics, Perinatology and Child Health, DNA, Viral, Brief Reports, Female, business, Pediatric population
Abstract

We conducted a multicenter clinical validity study of the Panbio coronavirus disease 2019 Antigen Rapid Test of nasopharyngeal samples in pediatric patients with coronavirus disease 2019-compatible symptoms of ≤5 days of evolution. Our study showed limited accuracy in nasopharyngeal antigen testing: overall sensitivity was 45.4%, and 99.8% of specificity, positive-predictive value was 92.5%.

Published
2020

9. SARS-CoV-2 infection in ambulatory and hospitalised Spanish children

Author

Cristina Calvo, Teresa Del Rosal, Fernando Baquero-Artigao, Talía Sainz, Irene Martín-Espín, María de Ceano-Vivas, Marta Plata-Gallardo, Ana Méndez-Echevarría, Julia Martín-Sánchez, Miguel Ángel Molina-Gutiérrez, Jose Antonio Ruíz-Domínguez, Paula García-Sánchez, Marta Bueno-Barriocanal, Begoña de Miguel-Lavisier, Rosario López-López, Isabel González-Bertolín, and Patricia Bote-Gascón

Subjects
Male, medicine.medical_specialty, Pediatrics, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pneumonia, Viral, law.invention, 03 medical and health sciences, Betacoronavirus, 0302 clinical medicine, COVID-19 Testing, law, 030225 pediatrics, Epidemiology, Pandemic, medicine, Ambulatory Care, Humans, Pediatrics, Perinatology, and Child Health, Child, Pandemics, Retrospective Studies, business.industry, Clinical Laboratory Techniques, SARS-CoV-2, Outbreak, COVID-19, Retrospective cohort study, PostScript, Prognosis, Intensive care unit, virology, Hospitalization, Spain, Child, Preschool, Pediatrics, Perinatology and Child Health, Ambulatory, epidemiology, Female, business, Coronavirus Infections
Abstract

Limited paediatric data on COVID-19 suggest that it is less frequent and severe in children than in adults.1 2 Spain is currently one of the most affected countries. Our aim was to describe the patients under the age of 18 years diagnosed with SARS-CoV-2 infection at Hospital La Paz (Madrid) in the first month of the outbreak (11 March to 9 April 2020). Inclusion criteria were all children who underwent PCR for SARS-CoV-2 in nasopharyngeal smears. Out of 349 children, 58 (16.6%) had a positive PCR for SARS-CoV-2 (table 1). All had compatible symptoms, except two cases in which the PCR was indicated prior to intensive care unit (ICU) admission or surgery. Twenty-five (43%) children were followed up as outpatients. Nine of them (35%) attended a second time but none required hospital …

Published
2020

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