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328 results on '"Martelli, Antonietta"'

8. Measurement of sorafenib plasma concentration by high-performance liquid chromatography in patients with advanced hepatocellular carcinoma: is it useful the application in clinical practice? A pilot study

Author

Fucile, Carmen, Marenco, Simona, Bazzica, Marco, Zuccoli, Maria Laura, Lantieri, Francesca, Robbiano, Luigi, Marini, Valeria, Di Gion, Paola, Pieri, Giulia, Stura, Paola, Martelli, Antonietta, Savarino, Vincenzo, Mattioli, Francesca, and Picciotto, Antonino

Published
2015
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27. An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans

Author

Bonassi, Stefano, Znaor, Ariana, Ceppi, Marcello, Lando, Cecilia, Chang, Wushou Peter, Holland, Nina, Kirsch-Volders, Micheline, Zeiger, Errol, Ban, Sadayuki, Barale, Roberto, Bigatti, Maria Paola, Bolognesi, Claudia, Cebulska-Wasilewska, Antonina, Fabianova, Eleonora, Fucic, Alexandra, Hagmar, Lars, Joksic, Gordana, Martelli, Antonietta, Migliore, Lucia, Mirkova, Ekaterina, Scarfi, Maria Rosaria, Zijno, Andrea, Norppa, Hannu, and Fenech, Michael

Published
2007

32. Intra- and inter-laboratory variation in the scoring of micronuclei and nucleoplasmic bridges in binucleated human lymphocytes: Results of an international slide-scoring exercise by the HUMN project

Author

Fenech, Michael, Bonassi, Stefano, Turner, Julie, Lando, Cecilia, Ceppi, Marcello, Chang, Wushou Peter, Holland, Nina, Kirsch-Volders, Micheline, Zeiger, Errol, Bigatti, Maria Paola, Bolognesi, Claudia, Cao, Jia, De Luca, Giuseppe, Di Giorgio, Marina, Ferguson, Lynnette R., Fucic, Aleksandra, Lima, Omar Garcia, Hadjidekova, Valeria V., Hrelia, Patrizia, Jaworska, Alicja, Joksic, Gordana, Krishnaja, A.P., Lee, Tung-Kwang, Martelli, Antonietta, McKay, Michael J., Migliore, Lucia, Mirkova, Ekaterina, Müller, Wolfgang-Ulrich, Odagiri, Youichi, Orsiere, Thierry, Scarfı̀, Maria Rosaria, Silva, Maria J., Sofuni, Toshio, Suralles, Jordi, Trenta, Giorgio, Vorobtsova, Irena, Vral, Anne, and Zijno, Andrea

Published
2003
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41. Co-Occurring Psychiatric and Substance Use Disorders: Clinical Survey Among a Rural Cohort of Italian Patients

Author

Milano,Giulia, Vergani,Hayley M, Cattedra,Simone, Carrozzino,Roberto, Mattioli,Francesca, Robbiano,Luigi, Martelli,Antonietta, Milano,Giulia, Vergani,Hayley M, Cattedra,Simone, Carrozzino,Roberto, Mattioli,Francesca, Robbiano,Luigi, and Martelli,Antonietta

Abstract

Giulia Milano,1,* Hayley M Vergani,1,* Simone Cattedra,1 Roberto Carrozzino,2 Francesca Mattioli,1 Luigi Robbiano,1 Antonietta Martelli1 1Department of Internal Medicine, Clinical Pharmacology and Toxicology Unit, University of Genoa, Genoa, Italy; 2Department of Addiction, Health Service ASL2 Savonese, Savona, Italy*These authors contributed equally to this workCorrespondence: Hayley M VerganiDepartment of Internal Medicine, Clinical Pharmacology and Toxicology Unit, University of Genoa, Viale Benedetto XV, 2, Genoa I-16132, ItalyTel +39 0103538850Fax +39 0103538232Email hayley.vergani@gmail.comPurpose: Dual diagnosis (DD) is the co-occurrence of both a mental illness and a substance use disorder (SUD). Lots of studies have analysed the integrated clinical approach, which involves both psychiatry and toxicology medical experts. The purpose of this study is to analyse the socio-demographic characteristics and treatment strategies of patients with DD in a rural area of Italy.Patients and Methods: Clinical data of 750 patients were collected in 2016 through the analysis of health plan records.Results: The rate of co-occurring disorders is highly variable among people with SUD. In the considered area, patients with DD are 24%, of these only 46.1% have been treated with an integrated clinical program. Moreover, this percentage is further reduced (35.8%) if only patients with heroin use disorder are considered.Conclusion: A comprehensive revision of DD treatment is needed, especially for people suffering from heroin use disorder and living in remote areas. Meticulous data analysis from other addiction health services of rural areas could be necessary to identify a science-based clinical intervention.Keywords: dual diagnosis, integrated treatments, substance use disorder, social stigma, rural populations

Published
2019

46. A Uhplc–Ms/Ms Method for the Quantification of Δ9-tetrahydrocannabinol and Cannabidiol in Decoctions and in Plasma Samples for Therapeutic Monitoring of Medical Cannabis

Author

Barco, Sebastiano, primary, Fucile, Carmen, additional, Manfredini, Luca, additional, De Grandis, Elisa, additional, Gherzi, Marcella, additional, Martelli, Antonietta, additional, Tripodi, Gino, additional, Mattioli, Francesca, additional, and Cangemi, Giuliana, additional

Published
2018
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49. What is known about deferasirox chelation therapy in pediatric HSCT recipients: two case reports of metabolic acidosis

Author

Fucile,Carmen, Mattioli,Francesca, Marini,Valeria, Gregori,Massimo, Sonzogni,Aurelio, Martelli,Antonietta, Maximova,Natalia, Fucile,Carmen, Mattioli,Francesca, Marini,Valeria, Gregori,Massimo, Sonzogni,Aurelio, Martelli,Antonietta, and Maximova,Natalia

Abstract

Carmen Fucile,1 Francesca Mattioli,1 Valeria Marini,1 Massimo Gregori,2 Aurelio Sonzogni,3 Antonietta Martelli,1 Natalia Maximova4 1Pharmacology and Toxicology Unit, University of Genoa, Genoa, Italy; 2Department of Pediatric Radiology, Institute for Maternal and Child Health – IRCCS Burlo Garofalo, Trieste, Italy; 3Department of Pathology, Ospedale Beato Papa Giovanni XIII, Bergamo, Italy; 4Bone Marrow Transplant Unit, Institute for Maternal and Child Health – IRCCS Burlo Garofalo, Trieste, Italy Abstract: To date, in pediatric field, various hematological malignancies are increasingly treated with allogeneic hematopoietic stem cell transplantation (allo-HSCT). Iron overload and systemic siderosis often occur in this particular cohort of patients and are associated with poor prognosis. We describe herein the case of two allo-HSCT patients, on treatment with deferasirox; they showed histopathological elements compatible with venoocclusive disease or vanishing bile duct syndrome in ductopenic evolution before deferasirox started. The first patient developed drug-induced liver damage with metabolic acidosis and the second one a liver impairment with Fanconi syndrome. After withdrawing deferasirox treatment, both patients showed improvement. Measurements of drug plasma concentrations were performed by HPLC assay. The reduction and consequent disappearance of symptoms after the suspension of deferasirox substantiate its role in inducing hepatic damage, probably enabling the diagnosis of drug-induced liver damage. But the difficulties in diagnosing drug-related toxicity must be underlined, especially in compromised subjects. For these reasons, in patients requiring iron-chelating therapy, close and careful drug therapeutic monitoring is strongly recommended. Keywords: deferasirox, allogeneic hematopoietic stem cell transplantation, allo-HSCT, pediatric, ductopenia, therapeutic drug monitoring, adverse events

Published
2018

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