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11. Immunologisch relevante Marker beim Ovarialkarzinom

Author

Zeimet, A.G., primary, Herold, M., additional, Marth, Ch., additional, Uhl-Steidl, M., additional, Müller-Holzner, E., additional, Widschwendter, M., additional, Windbichler, G., additional, Penz-Koza, A., additional, Daxenbichler, G., additional, and Dapunt, O., additional

Published
1994
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18. Die Wertigkeit von Tumormarkern beim Vulvakarzinom

Author

Zeimet, A.G., primary, Marth, Ch., additional, Abfalter, E., additional, Müller-Holzner, E., additional, Heim, K., additional, Pinzger, G., additional, Baumgartner, P., additional, Daxenbichler, G., additional, and Dapunt, O., additional

Published
1992
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26. Clinical presentation of CMV infection in solid organ transplant recipients and its impact on graft rejection and neopterin excretion

Author

Tilg, H., Margreiter, R., Scriba, M., Marth, Ch., Niederwieser, D., Aulitzky, W., Spielberger, M., Wachter, H., and Ruber, Ch.

Abstract

CMV serotesting by means of ELISA was performed every alternate week in 160 patients receiving renal (n= 117), pancreas (n = 18), liver (n = 17) and heart allografts (n = 8). Prophylactic immunosuppression consisted of Cyclosporin A plus methylprednisone and was identical for the different groups of transplant patients studied. In parallel, urinary neopterin values were studied in these cases. Thirty‐eight CMV infections were observed. Of these, 74% represented secondary infections and approximately 50% were symptomatic. CMV infections preferentially occurred in hyperimmunosuppressed individuals as evidenced by (i) an almost complete lack of early acute rejection episodes in transplant recipients who subsequently experienced infection, and (ii) aggravation of severity of infection after intensification of immunosuppressive treatment. The incidence of CMV infection was also markedly increased in polytransfused organ recipients, and evidence suggests that immunosuppression by blood transfusion rather than transmission of virus is responsible. CMV infection and, in particular, CMV disease, at least in renal transplant recipients, negatively influenced graft survival: this was thought to represent a consequence of CMV‐induced enhancement of alloreactivity as well as a consequence of deliberate reduction of immunosuppression during serious CMV disease. Evaluation of the neopterin marker, although not specific, proved to be clinically useful for three reasons: (i) neopterin in response to CMV infection increases approximately 1 wk earlier than antibodies, (ii) the magnitude of CMV‐induced neopterin responses is related to the severity of the infection, and (iii) normalization of neopterin levels is related to resolution of CMV disease.

Published
1987
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27. Correlation of Biochemical (Receptors, Endogenous Tissue Hormones) and Quantitative Morphologic (Stereologic) Findings in Normal and hyperplastic Human Prostates

Author

Bartsch, G., Keen, F., Daxenbichler, G., Marth, Ch., Margreiter, R., Brüngger, A., Sutter, T., and Rohr, H.P.

Abstract

In previous light and electron-microscopic analyses human benign prostatic hyperplasia was shown to be predominantly a stromal disease; the aim of the present study was to correlate the stereological data with the levels of the endogenous tissue hormones (androgens, estrogens, progesterone) in normal (N) and hyperplastic human prostatic tissues (BPH). BPH tissue specimens were obtained by open prostatectomy (n = 25); normal prostatic tissue was obtained from kidney donors (n = 5).

Published
1987
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32. Effect of Neopterin Derivatives on Mitochondrial Dehydrogenase Activity in Ovarian Carcinoma Cell Lines in Vitro

Author

Rieder Josef, Marth Christian, and Hoffmann' Georg

Subjects
7,8-dihydroneopterin, neopterin. ovarian carcinoma, tumor growth, Crystallography, QD901-999
Abstract

In a recent study we could show that neopterin inhibits nitric oxide-induced apoptosis in ovarian carcinoma cells. This may provide an explanation for the correlation between increased levels of neopterin derivatives and the unfavorable prognosis in patients with ovarian cancer that has been described in the literature. To obtain additional information on the mode of action of neopterin derivatives within the tumor environment, we studied the effects of neopterin (100 and 1000 μΜ) and 7,8-dihydroneopterin (100, 500, and 1000 μΜ) on mitochondrial dehydrogenase activity in three different ovarian carcinoma cell lines (2774, HOC-1, and OVCAR-3). 7,8-dihydroneopterin was an effective stimulus of mitochondrial enzyme turnover rate in any cell culture model under investigation. This suggests that the pteridine compound stabilizes tumor cell viability and therefore acts as a promotor of tumor growth. In contrast to 7.8-dihydroneopterin, neopterin did not affect mitochondrial dehydrogenases in 2774, HOC-7, or OVCAR-3 cells. However, in HOC-7 and OCVAR-3, neopterin was found to antagonize the stimulating effects of 7,8-dihydroneopterin. This might be due to the different impact of both pteridine compounds on the redox status in these cells. Our new data provide further evidence of distinct biochemical effects of neopterin derivatives in ovarian carcinoma cells. Neopterin and 7,8-dihydroneopterin may be involved in separate stages of cellular changes that lead to malignancy or promote tumor progression.

Published
2006
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33. Neopterin as a Stimulator of Vascular Endothelial Growth Factor and Erythropoietin Gene Expression in an Ovarian Carcinoma Cell Line

Author

Rieder Josef, Marth Christian, Schobersberger Wolfgang, and Hoffmann Georg

Subjects
neopterin, vascular endothelial growth factor, erythropoietin, ovarian carcinoma cells, Crystallography, QD901-999
Abstract

Increases in serum neopterin concentrations are a regular finding in patients with ovarian cancer. The strong correlation between neopterin and tumor progression might be explained by a direct influence of the pteridine compound on tumor cell growth. In the present study we investigated whether neopterin affects the production of the angiogenic promotors vascular endothelial growth factor (VEGF) and erythropoietin (EPO) in the human ovarian carcinoma cell line OVCAR-3. VEGF and EPO gene expression were detected via RT-PCR. and a possible involvement of hypoxiainducible factor-1 was assessed by electrophoretic mobility shift assays. Neopterin amplified the hypoxia-induced VEGF and EPO gene expression as well as protein synthesis in a concentration-dependent manner. In addition, generation of both VEGF and EPO could be detected following incubation of cells with neopterin under normoxic conditions, too. Neopterin-induced synthesis of VEGF and EPO was preceeded by a stimulation of hypoxiainducible factor-1 uptake into the nucleus of OVCAR-3 cells. From these data we conclude that neopterin acts as a mediator of angiogenesis. Stimulation of VEGF and EPO generation in ovarian carcinoma cells may promote vascularization of the malignant tissue and thus tumor growth and development.

Published
2005
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