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2. Crisscrossing Learning Experiences in an Undergraduate Research-Based Laboratory Course to Promote Reciprocal Peer Learning

Author

Maha Zewail-Foote and Marti´n Gonzalez

Abstract

In an effort to improve student learning, authentic research experiences have been incorporated into introductory laboratory courses as a means to teach students scientific inquiry and engage them in the scientific process. Here, we describe the development and implementation of a novel undergraduate research-based laboratory course for first-year students where students swap projects midsemester. Swapping research projects establishes reciprocal peer learning partnerships, thereby empowering students to simultaneously be both peer teachers and active learners in an introductory laboratory course. Our Crisscrossing Learning Experience (CCLE) course was designed to promote a high level of collaboration, sense of ownership, and science identity among first-year students through the learning by teaching paradigm and close mentoring.

Published
2023
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3. Text Classification of Users Claiming to Have ASD Using Traditional Machine Learning Techniques

Author

Rubio-Martí­n, Sergio, Garcí­a-Ordás, María Teresa, Bayón-Gutiérrez, Martí­n, Martí­nez Villamea, Silvia, Arias-Ramos, Natalia, Bení­tez-Andrades, José Alberto, Bezaeva, Natalia S., Series Editor, Gomes Coe, Heloisa Helena, Series Editor, Nawaz, Muhammad Farrakh, Series Editor, Benítez-Andrades, José Alberto, editor, García-Llamas, Paula, editor, Taboada, Ángela, editor, Estévez-Mauriz, Laura, editor, and Baelo, Roberto, editor

Published
2023
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9. Traceability and Accountability in Autonomous Agents

Author

Rodríguez-Lera, Francisco Javier, González Santamarta, Miguel Ángel, Guerrero, Ángel Manuel, Martí­n, Francisco, Matellán, Vicente, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Herrero, Álvaro, editor, Cambra, Carlos, editor, Urda, Daniel, editor, Sedano, Javier, editor, Quintián, Héctor, editor, and Corchado, Emilio, editor

Published
2021
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10. Consolidation nivolumab and ipilimumab versus observation in limited-disease small-cell lung cancer after chemo-radiotherapy – results from the randomised phase II ETOP/IFCT 4-12 STIMULI trial

Author

Stahel, R., Hiltbrunner, A., Pardo-Contreras, M., Gasca-Ruchti, A., Giacomelli, N., Kammler, R., Marti, N., Pfister, R., Piguet, A.C., Roux, S., Troesch, S., Schneider, M., Schweri, R., Zigomo, I., Tsourti, Z., Zygoura, P., Tsouprou, S., Kassapian, M., Vervita, K., Dimopoulou, G., Andriakopoulou, C., Morin, F., Amour, E., Mariaule, G., Archirel, N., Fernandez, M., Pereira, E., Benito, L., Lopez, K., Hernández, A., Chinchen, S., Jurkovic, H., Livingstone, A., Mitchell, J., Walker, M., Mitchell, P., Ng, S., Steer, C., Briscoe, K., Saqib, A., Abdi, E., Houghton, B., O’Byrne, K., Chittajallu, B.R., Hughes, B.G., Black, A., Nackaerts, K., Werner, H., Gervais, R., Zalcman, G., Vaylet, F., Merle, P., Monnet, I., Moro-Sibilot, D., Molinier, O., Girard, N., Souquet, P.-J., Barlesi, F., Debieuvre, D., Senellart, H., Poudenx, M., Dixmier, A., Pouessel, D., Cadranel, J., Lena, H., Quoix, E., Friard, S., Audigier-Valette, C., Mazieres, J., Pichon, E., Faehling, M., Kokowski, K., Kirchen, H., Griesinger, F., Tufman, A., De-Colle, C., de Langen, J., González Larriba, J.L., Insa, A., Majem, M., Massutí, B., Pulla, M.P., Aix, S.P., Villanueva, N., Vivanco, G.L., Andrade, J., Curioni-Fontecedro, A., Franks, K., Califano, R., Peters, S., Pujol, J.-L., Dafni, U., Dómine, M., Popat, S., Reck, M., Becker, A., Insa Mollá, A., López Vivanco, G., Madelaine, J., Provencio Pulla, M., Roschitzki-Voser, H., Ruepp, B., Stahel, R.A., Le Pechoux, C., and De Ruysscher, D.

Published
2022
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15. (P^N^C) Ligands to Stabilize Gold(III): A Straightforward Access to Hydroxo, Formate, and Hydride Complexes

Author

Marti´n, Jaime, Scho¨rgenhumer, Johannes, Biedrzycki, Michal, and Nevado, Cristina

Abstract

A novel class of (P^N^C) pincer ligands capable of stabilizing elusive gold(III) species is reported here. Straightforward access to (P^N^C)gold(III) hydroxo, formate, and hydride complexes has been streamlined by first incorporating a cycloauration step devoid of toxic metals or harsh conditions. The resulting gold complexes exhibit remarkable stability in solution as well as in the solid state under ambient conditions, which enabled their characterization by X-ray diffraction analyses. Interestingly, the influence of the ligand allowed the preparation of gold(III)-hydrides using mild hydride donors such as H-Bpin, which contrasts with sensitive super hydrides or strong acids and cryogenic conditions employed in previous protocols. A detailed bonding characterization of these species is complemented by reactivity studies.

Published
2024
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17. Effect of nonlinear exercise program through mHealth System (ATOPE+) on isokinetic strenght in patients with breast cancer undergoing medical treatments

Author

Lopez-Garzon, M, Alberti, P, Postigo-Martin, P, Gonzàlez-Santos, A, Gilgutiérrez, R, Salinas-Asensio, M, Ramirez-Prada, K, Puertas-Marti, N, Galiano-Castilo, N, Cantarereo-Villanueva, I, GilGutiérrez, R, Salinas-Asensio, MM, Puertas-Martin. M, Lopez-Garzon, M, Alberti, P, Postigo-Martin, P, Gonzàlez-Santos, A, Gilgutiérrez, R, Salinas-Asensio, M, Ramirez-Prada, K, Puertas-Marti, N, Galiano-Castilo, N, Cantarereo-Villanueva, I, GilGutiérrez, R, Salinas-Asensio, MM, and Puertas-Martin. M

Published
2023

18. Computational Study of Amyloidß42Familial Mutations and Metal Interaction: Impact on Monomers and Aggregates Dynamical Behaviors

Author

Rolda´n-Marti´n, Lorena, Sodupe, Mariona, and Mare´chal, Jean-Didier

Abstract

One of the main hallmarks of Alzheimer’s Disease is the formation of ß-amyloid plaques, whose formation may be enhanced by metal binding or the appearance of familial mutations. In the present study, the simultaneous effect of familial mutations (E22Q, E22G, E22K, and D23N) and binding to metal ions (Cu(II) or Al(III)) is studied at the Aß42monomeric and fibrillar levels. With the application of GaMD and MD simulations, it is observed that the effects of metal binding and mutations differ in the monomeric and fibrillar forms. In the monomeric structures, without metal binding, all mutations reduce the amount of a-helix and increase, in some cases, the ß-sheet content. In the presence of Cu(II) and Al(III) metal ions, the peptide becomes less flexible, and the ß-sheet content decreases in favor of forming a-helix motifs that stabilize the system through interhelical contacts. Regarding the fibrillar structures, mutations decrease the opening of the fiber in the vertical axis, thereby stabilizing the S-shaped structure of the fiber. This effect is, in general, enhanced upon metal binding. These results may explain the different Aß42aggregation patterns observed in familial mutations.

Published
2024
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21. Expression of phosphorylated ribosomal protein S6 in mesothelioma patients-correlation with clinico-pathological characteristics and outcome: results from the European Thoracic Oncology Platform (ETOP) Mesoscape project (Oct, 10.1038/s41379-022-01170-z, 2022)

Author

Ruschoff, J.H., Haberecker, M., Tsourti, Z., Nackaerts, K., Perrot, M. de, Brcic, L., Nadal, E., Tsimpoukis, S., Gray, S.G., Ampollini, L., Aerts, J.G., Felley-Bosco, E., Kirschner, M.B., Monkhorst, K., Weynand, B., Bavaghar-Zaeimi, F., Samarzija, M., Llatjos, R., Finn, S.P., Silini, E., Thusen, J. von der, Marti, N., Vervita, K., Kammler, R., Peters, S., Stahel, R.A., Baas, P., Opitz, I., and Consortium, E.M.

Published
2022
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22. Alternatives to Parameter Selection for Kernel Methods

Author

Muñoz, Alberto, de Diego, Isaac Martí n, Moguerza, Javier M., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Kollias, Stefanos D., editor, Stafylopatis, Andreas, editor, Duch, Włodzisław, editor, and Oja, Erkki, editor

Published
2006
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23. From Indefinite to Positive Semi-Definite Matrices

Author

Muñoz, Alberto, de Diego, Isaac Martí n, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Yeung, Dit-Yan, editor, Kwok, James T., editor, Fred, Ana, editor, Roli, Fabio, editor, and de Ridder, Dick, editor

Published
2006
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35. Multicentric Study on High-Frequency Ultrasound Characterization of Calcium Deposits in Dermal and Subcutaneous Calciphylaxis and Calcinosis

Author

Gamissans, M, Giavedoni, P, Roe, E, Sanchez, J, Quintana-Codina, M, Garbayo-Salmons, P, Vidal, D, Riera-Marti, N, Lopez-Llunell, C, Romani, J, and Wortsman, X

Subjects
calcium, ultrasound, calciphylaxis, dermatologic ultrasound, calcinosis cutis
Abstract

Objectives Calcium depositions are frequent in multiple inflammatory dermatosis, they can be explored by ultrasound (US) but the patterns of these depositions have not yet been described. The aim of this study is to describe different patterns of calcium deposition in inflammatory dermatoses. Methods The clinical and US data of 58 patients from 7 different centers with inflammatory dermatosis showing ultrasonography-detected calcium depositions was retrospectively reviewed. Results Dystrophic calcinosis represented 86.2%, calciphylaxis 8.6%, and metastatic calcinosis 5.2%. Three different sonographic patterns of calcium deposition were found: 1) thin hyperechoic bands, parallel to the surface of the epidermis, generating a strong and wide posterior acoustic shadow; 2) hyperechoic spots or lumps with a narrow acoustic shadow; and 3) a linear hyperechoic band parallel to the walls of a blood vessel with also a narrow acoustic shadow. The predominant pattern in metastatic calcifications was type 1, in dystrophic calcifications type 2, and in calciphylaxis type 3. In dystrophic calcinosis, cutis deposits were longer and wider than in calciphylaxis (P < .05). Conclusion New data on inflammatory dermatoses with calcium deposition may be useful for the diagnosis and monitoring of calcium deposits and could avoid the performance of more invasive tests, such as a skin biopsy.

Published
2022

36. Use of Exoskeletons in the Treatment and Rehabilitation of Paraplegia Patients

Author

Martiñón, Susana and Hernández-Miramontes, Ricardo

Subjects
Medical
Abstract

This chapter presents a review that includes five robotic exoskeletons used in the rehabilitation of paraplegic patients, highlighting the qualities of each one and offering the doctor and the rehabilitator a tool to select the exoskeleton that is most appropriate to the needs of their patient and a more satisfying and integral therapy. A systematic search was carried out in different platforms of scientific interest, the publications that met the inclusion criteria were selected. The information collected was classified and synthesized, resulting in a review that covers the five most relevant exoskeletons for the rehabilitation of paraplegic patients. Concluding with a tool that helps the therapist select the most appropriate exoskeleton for each patient.

Published
2022

42. Consolidation nivolumab and ipilimumab versus observation in limited-disease small-cell lung cancer after chemo-radiotherapy – results from the randomised phase II ETOP/IFCT 4-12 STIMULI trial

Author

Peters, S., primary, Pujol, J.-L., additional, Dafni, U., additional, Dómine, M., additional, Popat, S., additional, Reck, M., additional, Andrade, J., additional, Becker, A., additional, Moro-Sibilot, D., additional, Curioni-Fontecedro, A., additional, Molinier, O., additional, Nackaerts, K., additional, Insa Mollá, A., additional, Gervais, R., additional, López Vivanco, G., additional, Madelaine, J., additional, Mazieres, J., additional, Faehling, M., additional, Griesinger, F., additional, Majem, M., additional, González Larriba, J.L., additional, Provencio Pulla, M., additional, Vervita, K., additional, Roschitzki-Voser, H., additional, Ruepp, B., additional, Mitchell, P., additional, Stahel, R.A., additional, Le Pechoux, C., additional, De Ruysscher, D., additional, Stahel, R., additional, Hiltbrunner, A., additional, Pardo-Contreras, M., additional, Gasca-Ruchti, A., additional, Giacomelli, N., additional, Kammler, R., additional, Marti, N., additional, Pfister, R., additional, Piguet, A.C., additional, Roux, S., additional, Troesch, S., additional, Schneider, M., additional, Schweri, R., additional, Zigomo, I., additional, Tsourti, Z., additional, Zygoura, P., additional, Tsouprou, S., additional, Kassapian, M., additional, Dimopoulou, G., additional, Andriakopoulou, C., additional, Morin, F., additional, Amour, E., additional, Mariaule, G., additional, Archirel, N., additional, Fernandez, M., additional, Pereira, E., additional, Benito, L., additional, Lopez, K., additional, Hernández, A., additional, Chinchen, S., additional, Jurkovic, H., additional, Livingstone, A., additional, Mitchell, J., additional, Walker, M., additional, Ng, S., additional, Steer, C., additional, Briscoe, K., additional, Saqib, A., additional, Abdi, E., additional, Houghton, B., additional, O’Byrne, K., additional, Chittajallu, B.R., additional, Hughes, B.G., additional, Black, A., additional, Werner, H., additional, Zalcman, G., additional, Vaylet, F., additional, Merle, P., additional, Monnet, I., additional, Girard, N., additional, Souquet, P.-J., additional, Barlesi, F., additional, Debieuvre, D., additional, Senellart, H., additional, Poudenx, M., additional, Dixmier, A., additional, Pouessel, D., additional, Cadranel, J., additional, Lena, H., additional, Quoix, E., additional, Friard, S., additional, Audigier-Valette, C., additional, Pichon, E., additional, Kokowski, K., additional, Kirchen, H., additional, Tufman, A., additional, De-Colle, C., additional, de Langen, J., additional, Insa, A., additional, Massutí, B., additional, Pulla, M.P., additional, Aix, S.P., additional, Villanueva, N., additional, Vivanco, G.L., additional, Franks, K., additional, and Califano, R., additional

Published
2022
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47. Efecto antiinflamatorio del extracto etanólico de la corteza de Tabebuia impetiginosa (Mart. ex DC.) Standley, guayacan, en ratas

Author

Jorge Luis Arroyo-Acevedo, Arilme Gorriti Gutierrez, Marcelino Sarmiento-Campos, and Marti­n Condorhuaman-Figueroa

Subjects
General Medicine
Abstract

Objetivos.Evaluar el efecto antiinflamatorio del extracto etanólico de corteza de Tabebuia impetiginosa (Mart. Ex. DC) Standley, guayacán,en un modelo in vivo en ratas.Materiales y Métodos. Se utilizaron 36 ratas repartidas en seis grupos. Se preparó el extracto macerando 100 g de cortezas de Tabebuia impetiginosa, durante siete días.Al grupo I se administró suero fisiológico al 0,9 % (2 mL/kg); grupo II: ibuprofeno (20 mg/kg); Grupo III: dexametasona (20 mg/kg); Los grupos IV, V y VI de extracto etanólico de Tabebuia impetiginosa (Mart. Ex. DC)Standley, guayacán, en dosis de 50 mg/kg, 250 mg/kg y 500 mg/kg, respectivamente. A los 30 min se aplicó 0,2 mL de carragenina en la pata izquierda de las ratas, para inducir la inflamación. Se midió el diámetro de las patas en milímetros en tiempos de 1, 4 y 14 horas. Resultados. Presencia de antraquinonas, compuestos fenólicos, flavonoides, saponinas esteroidales y taninos. Además, se observan indicios de efecto antiinflamatorio del extracto etanólico de Tabebuia impetiginosa a 250 mg/kg, sin ser concluyentes. Conclusión. El extracto etanólico de la corteza de Tabebuia impetiginosa (Mart. ex DC.) Standley, guayacán, en dosis de 250 mg/kg puede tener efecto antiinflamatorio en un modelo murino de inflamación aguda con carragenina.

Published
2019
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