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Determining whether two STRIPS planning instances are isomorphic is the simplest form of comparison between planning instances. It is also a particular case of the problem concerned with finding an isomorphism between a planning instance $P$ and a sub-instance of another instance $P_0$ . One application of such a mapping is to efficiently produce a compiled form containing all solutions to P from a compiled form containing all solutions to $P_0$. We also introduce the notion of embedding from an instance $P$ to another instance $P_0$, which allows us to deduce that $P_0$ has no solution-plan if $P$ is unsolvable. In this paper, we study the complexity of these problems. We show that the first is GI-complete, and can thus be solved, in theory, in quasi-polynomial time. While we prove the remaining problems to be NP-complete, we propose an algorithm to build an isomorphism, when possible. We report extensive experimental trials on benchmark problems which demonstrate conclusively that applying constraint propagation in preprocessing can greatly improve the efficiency of a SAT solver.

Compared to the wide array of advanced Monte Carlo methods supported by modern probabilistic programming languages (PPLs), PPL support for variational inference (VI) is less developed: users are typically limited to a predefined selection of variational objectives and gradient estimators, which are implemented monolithically (and without formal correctness arguments) in PPL backends. In this paper, we propose a more modular approach to supporting variational inference in PPLs, based on compositional program transformation. In our approach, variational objectives are expressed as programs, that may employ first-class constructs for computing densities of and expected values under user-defined models and variational families. We then transform these programs systematically into unbiased gradient estimators for optimizing the objectives they define. Our design enables modular reasoning about many interacting concerns, including automatic differentiation, density accumulation, tracing, and the application of unbiased gradient estimation strategies. Additionally, relative to existing support for VI in PPLs, our design increases expressiveness along three axes: (1) it supports an open-ended set of user-defined variational objectives, rather than a fixed menu of options; (2) it supports a combinatorial space of gradient estimation strategies, many not automated by today's PPLs; and (3) it supports a broader class of models and variational families, because it supports constructs for approximate marginalization and normalization (previously introduced only for Monte Carlo inference). We implement our approach in an extension to the Gen probabilistic programming system (genjax.vi, implemented in JAX), and evaluate on several deep generative modeling tasks, showing minimal performance overhead vs. hand-coded implementations and performance competitive with well-established open-source PPLs.

Variability can be the pathway to understanding the physical processes in astrophysical jets, however, the high-cadence observations required to test particle acceleration models are still missing. Here we report on the first attempt to produce continuous, >24 hour polarization light curves of blazars using telescopes distributed across the globe and the rotation of the Earth to avoid the rising Sun. Our campaign involved 16 telescopes in Asia, Europe, and North America. We observed BL Lacertae and CGRaBS J0211+1051 for a combined 685 telescope hours. We find large variations in the polarization degree and angle for both sources in sub-hour timescales as well as a ~180 degree rotation of the polarization angle in CGRaBS J0211+1051 in less than two days. We compared our high-cadence observations to Particle-In-Cell magnetic reconnection and turbulent plasma simulations. We find that although the state of the art simulation frameworks can produce a large fraction of the polarization properties, they do not account for the entirety of the observed polarization behavior in blazar jets., Comment: 20 pages, 15 figures, 2 tables, accepted for publication in A&A. The data used in the paper are available here: https://doi.org/10.7910/DVN/IETSXS

This article presents GenSQL, a probabilistic programming system for querying probabilistic generative models of database tables. By augmenting SQL with only a few key primitives for querying probabilistic models, GenSQL enables complex Bayesian inference workflows to be concisely implemented. GenSQL's query planner rests on a unified programmatic interface for interacting with probabilistic models of tabular data, which makes it possible to use models written in a variety of probabilistic programming languages that are tailored to specific workflows. Probabilistic models may be automatically learned via probabilistic program synthesis, hand-designed, or a combination of both. GenSQL is formalized using a novel type system and denotational semantics, which together enable us to establish proofs that precisely characterize its soundness guarantees. We evaluate our system on two case real-world studies -- an anomaly detection in clinical trials and conditional synthetic data generation for a virtual wet lab -- and show that GenSQL more accurately captures the complexity of the data as compared to common baselines. We also show that the declarative syntax in GenSQL is more concise and less error-prone as compared to several alternatives. Finally, GenSQL delivers a 1.7-6.8x speedup compared to its closest competitor on a representative benchmark set and runs in comparable time to hand-written code, in part due to its reusable optimizations and code specialization., Comment: 54 pages, 30 figures, 1 table, published at PLDI 2024

We present the first X-ray spectropolarimetric results for Cygnus X-1 in its soft state from a campaign of five IXPE observations conducted during 2023 May-June. Companion multiwavelength data during the campaign are likewise shown. The 2-8 keV X-rays exhibit a net polarization degree PD=1.99%+/-0.13% (68% confidence). The polarization signal is found to increase with energy across IXPE's 2-8 keV bandpass. The polarized X-rays exhibit an energy-independent polarization angle of PA=-25.7+/-1.8 deg. East of North (68% confidence). This is consistent with being aligned to Cyg X-1's AU-scale compact radio jet and its pc-scale radio lobes. In comparison to earlier hard-state observations, the soft state exhibits a factor of 2 lower polarization degree, but a similar trend with energy and a similar (also energy-independent) position angle. When scaling by the natural unit of the disk temperature, we find the appearance of a consistent trendline in the polarization degree between soft and hard states. Our favored polarimetric model indicates Cyg X-1's spin is likely high (a* above ~0.96). The substantial X-ray polarization in Cyg X-1's soft state is most readily explained as resulting from a large portion of X-rays emitted from the disk returning and reflecting off the disk surface, generating a high polarization degree and a polarization direction parallel to the black hole spin axis and radio jet. In IXPE's bandpass, the polarization signal is dominated by the returning reflection emission. This constitutes polarimetric evidence for strong gravitational lensing of X-rays close to the black hole., Comment: 20 pages, accepted for publication in ApJL

Recent observations of X-ray pulsars (XRPs) performed by the Imaging X-ray Polarimetry Explorer (IXPE) have made it possible to investigate the intricate details of these objects in a new way, thanks to the added value of X-ray polarimetry. Here we present the results of the IXPE observations of SMC X-1, a member of the small group of XRPs displaying super-orbital variability. SMC X-1 was observed by IXPE three separate times during the high state of its super-orbital period. The observed luminosity in the 2-8 keV energy band of $L=2\times10^{38}$ erg/s makes SMC X-1 the brightest XRP ever observed by IXPE. We detect significant polarization in all three observations, with values of the phase-averaged polarization degree (PD) and polarization angle (PA) of $3.2\pm0.8$% and $97\deg\pm8\deg$ for Observation 1, $3.0\pm0.9$% and $90\deg\pm8\deg$ for Observation 2, and $5.5\pm1.1$% and $80\deg\pm6\deg$ for Observation 3, for the spectro-polarimetric analysis. The observed PD shows an increase over time with decreasing luminosity, while the PA decreases in decrements of 10\deg. The phase-resolved spectro-polarimetric analysis reveals significant detection of polarization in three out of seven phase bins, with the PD ranging between 2% and 10%, and a corresponding range in the PA from $\sim$70\deg\ to $\sim$100\deg. The pulse-phase resolved PD displays an apparent anti-correlation with the flux. Using the rotating vector model, we obtain constraints on the pulsar's geometrical properties for the individual observations. The position angle of the pulsar displays an evolution over time supporting the idea that we observe changes related to different super-orbital phases. Scattering in the wind of the precessing accretion disk may be responsible for the behavior of the polarimetric properties observed during the high-state of SMC X-1's super-orbital period., Comment: 11 pages, 11 figures, submitted to A&A

Feedback driven massive outflows play a crucial role in galaxy evolution by regulating star formation and influencing the dynamics of surrounding media. Extracting outflow properties from spectral lines is a notoriously difficult process for a number of reasons, including the possibility that a substantial fraction of the outflow is carried by dense gas in a very narrow range in velocity. This gas can hide in spectra with insufficient resolution. Empirically motivated analysis based on the Apparent Optical Depth method, commonly used in the literature, neglects the contribution of this gas, and may therefore underestimate the true gas column density. More complex semi-analytical line transfer (e.g., SALT) models, on the other hand, allow for the presence of this gas by modeling the radial density and velocity of the outflows as power laws. Here we compare the two approaches to quantify the uncertainties in the inferences of outflow properties based on 1-D "down-the-barrel" using the UV spectra of the CLASSY galaxy sample. We find that empirical modeling may significantly underestimate the column densities relative to SALT analysis, particularly in the optically thick regime. We use simulations to show that the main reason for this discrepancy is the presence of large amount of dense material at low velocities, which can be hidden by the finite spectral resolution of the data. The SALT models in turn could over-estimate the column densities if the assumed power laws of the density profiles strong are not a property of actual outflows., Comment: Submitted to ApJ, Comments welcome

We report the X-ray polarization properties of the high-synchrotron-peaked (HSP) blazar PKS 2155$-$304 based on observations with the Imaging X-ray Polarimetry Explorer (IXPE). We observed the source between Oct 27 and Nov 7, 2023. We also conducted an extensive contemporaneous multiwavelength (MW) campaign. We find that during the first half ($T_1$) of the IXPE pointing, the source exhibited the highest X-ray polarization degree detected for an HSP blazar thus far, (30.7$\pm$2.0)%, which dropped to (15.3$\pm$2.1)% during the second half ($T_2$). The X-ray polarization angle remained stable during the IXPE pointing at 129.4$^\circ$$\pm$1.8$^\circ$ and 125.4$^\circ$$\pm$3.9$^\circ$ during $T_1$ and $T_2$, respectively. Meanwhile, the optical polarization degree remained stable during the IXPE pointing, with average host-galaxy-corrected values of (4.3$\pm$0.7)% and (3.8$\pm$0.9)% during the $T_1$ and $T_2$, respectively. During the IXPE pointing, the optical polarization angle changed achromatically from $\sim$140$^\circ$ to $\sim$90$^\circ$ and back to $\sim$130$^\circ$. Despite several attempts, we only detected (99.7% conf.) the radio polarization once (during $T_2$, at 225.5 GHz): with degree (1.7$\pm$0.4)% and angle 112.5$^\circ$$\pm$5.5$^\circ$. The direction of the broad pc-scale jet is rather ambiguous and has been found to point to the east and south at different epochs; however, on larger scales (> 1.5 pc) the jet points toward the southeast ($\sim$135$^\circ$), similar to all of the MW polarization angles. Moreover, the X-ray to optical polarization degree ratios of $\sim$7 and $\sim$4 during $T_1$ and $T_2$, respectively, are similar to previous IXPE results for several HSP blazars. These findings, combined with the lack of correlation of temporal variability between the MW polarization properties, agree with an energy-stratified shock-acceleration scenario in HSP blazars., Comment: 17 pages, 10 figures, 4 tables, Accepted for publication in A&A

Collecting and annotating real-world data for the development of object detection models is a time-consuming and expensive process. In the military domain in particular, data collection can also be dangerous or infeasible. Training models on synthetic data may provide a solution for cases where access to real-world training data is restricted. However, bridging the reality gap between synthetic and real data remains a challenge. Existing methods usually build on top of baseline Convolutional Neural Network (CNN) models that have been shown to perform well when trained on real data, but have limited ability to perform well when trained on synthetic data. For example, some architectures allow for fine-tuning with the expectation of large quantities of training data and are prone to overfitting on synthetic data. Related work usually ignores various best practices from object detection on real data, e.g. by training on synthetic data from a single environment with relatively little variation. In this paper we propose a methodology for improving the performance of a pre-trained object detector when training on synthetic data. Our approach focuses on extracting the salient information from synthetic data without forgetting useful features learned from pre-training on real images. Based on the state of the art, we incorporate data augmentation methods and a Transformer backbone. Besides reaching relatively strong performance without any specialized synthetic data transfer methods, we show that our methods improve the state of the art on synthetic data trained object detection for the RarePlanes and DGTA-VisDrone datasets, and reach near-perfect performance on an in-house vehicle detection dataset., Comment: Submitted to and presented at SPIE Defense + Commercial Sensing 2024, 13 pages, 4 figures, 3 tables

Machine learning techniques are steadily becoming more important in modern biology, and are used to build predictive models, discover patterns, and investigate biological problems. However, models trained on one dataset are often not generalizable to other datasets from different cohorts or laboratories, due to differences in the statistical properties of these datasets. These could stem from technical differences, such as the measurement technique used, or from relevant biological differences between the populations studied. Domain adaptation, a type of transfer learning, can alleviate this problem by aligning the statistical distributions of features and samples among different datasets so that similar models can be applied across them. However, a majority of state-of-the-art domain adaptation methods are designed to work with large-scale data, mostly text and images, while biological datasets often suffer from small sample sizes, and possess complexities such as heterogeneity of the feature space. This Review aims to synthetically discuss domain adaptation methods in the context of small-scale and highly heterogeneous biological data. We describe the benefits and challenges of domain adaptation in biological research and critically discuss some of its objectives, strengths, and weaknesses through key representative methodologies. We argue for the incorporation of domain adaptation techniques to the computational biologist's toolkit, with further development of customized approaches., Comment: main manuscript + supplement

We study of the role of galaxy-galaxy interactions and disk instabilities in producing starburst activity in galaxies out to z=4. For this, we use a sample of 387 galaxies with robust total star formation rate measurements from Herschel, gas masses from ALMA, stellar masses and redshifts from multi-band photometry, and JWST/NIRCam rest-frame optical imaging. Using mass-controlled samples, we find an increased fraction of interacting galaxies in the starburst regime at all redshifts out to z=4. This increase correlates with star formation efficiency (SFE), but not with gas fraction. However, the correlation is weak (and only significant out to z=2), which could be explained by the short duration of SFE increase during interaction. In addition, we find that isolated disk galaxies make up a significant fraction of the starburst population. The fraction of such galaxies with star-forming clumps ("clumpy disks") is significantly increased compared to the main-sequence disk population. Furthermore, this fraction directly correlates with SFE. This is direct observational evidence for a long-term increase of SFE maintained due to disk instabilities, contributing to the majority of starburst galaxies in our sample and hence to substantial mass growth in these systems. This result could also be of importance for explaining the growth of the most massive galaxies at z>6., Comment: 14 pages, 5 figures. Submitted to ApJ. Comments welcome

Discovery of pulsations from a number of ultra-luminous X-ray (ULX) sources proved that accretion onto neutron stars can produce luminosities exceeding the Eddington limit by a couple of orders of magnitude. The conditions necessary to achieve such high luminosities as well as the exact geometry of the accretion flow in the neutron star vicinity are, however, a matter of debate. The pulse phase-resolved polarization measurements that became possible with the launch of the IXPE can be used to determine the pulsar geometry and its orientation relative to the orbital plane. They provide an avenue to test different theoretical models of ULX pulsars. In this paper we present the results of three IXPE observations of the first Galactic ULX pulsar Swift J0243.6+6124 during its 2023 outburst. We find strong variations of the polarization characteristics with the pulsar phase. The average polarization degree increases from about 5% to 15% as the flux dropped by a factor of three in the course of the outburst. The polarization angle (PA) as function of the pulsar phase shows two peaks in the first two observations, but changes to a characteristic sawtooth pattern in the remaining data set. This is not consistent with a simple rotating vector model. Assuming the existence of an additional constant polarized component, we were able to fit the three observations with a common rotating vector model and obtain constraints on the pulsar geometry. In particular, we find the pulsar angular momentum inclination with respect to the line-of-sight of 15-40 deg, the magnetic obliquity of 60-80 deg, and the pulsar spin position angle of -50 deg, which differs from the constant component PA of about 10 deg. Combining these X-ray measurements with the optical PA, we find evidence for a 30 deg misalignment between the pulsar spin and the binary orbital axis., Comment: 13 pages, 10 figures, submitted to A&A

Supernova remnants (SNRs) provide insights into cosmic-ray acceleration and magnetic field dynamics at shock fronts. Recent X-ray polarimetric measurements by the Imaging X-ray Polarimetry Explorer (IXPE) have revealed radial magnetic fields near particle acceleration sites in young SNRs, including Cassiopeia A, Tycho, and SN 1006. We present here the spatially-resolved IXPE X-ray polarimetric observation of the northwestern rim of SNR RX J1713.7-3946. For the first time, our analysis shows that the magnetic field in particle acceleration sites of this SNR is oriented tangentially with respect to the shock front. Because of the lack of precise Faraday-rotation measurements in the radio band, this was not possible before. The average measured polarization degree (PD) of the synchtrotron emission is 12.5 {\pm} 3.3%, lower than the one measured by IXPE in SN 1006, comparable to the Tycho one, but notably higher than the one in Cassiopeia A. On sub-parsec scales, localized patches within RX J1713.7-3946 display PD up to 41.5 {\pm} 9.5%. These results are compatible with a shock-compressed magnetic field. However, in order to explain the observed PD, either the presence of a radial net magnetic field upstream of the shock, or partial reisotropization of the turbulence downstream by radial magneto-hydrodynamical instabilities, can be invoked. From comparison of PD and magnetic field distribution with {\gamma}-rays and 12 CO data, our results provide new inputs in favor of a leptonic origin of the {\gamma}-ray emission., Comment: 18 pages, 6 figures, 2 tables, published in ApJ Letters

We show that the activation knot of a potentially non-stationary regressor on the adaptive Lasso solution path in autoregressions can be leveraged for selection-free inference about a unit root. The resulting test has asymptotic power against local alternatives in $1/T$ neighbourhoods, unlike post-selection inference methods based on consistent model selection. Exploiting the information enrichment principle devised by Reinschl\"ussel and Arnold arXiv:2402.16580 [stat.ME] to improve the Lasso-based selection of ADF models, we propose a composite statistic and analyse its asymptotic distribution and local power function. Monte Carlo evidence shows that the combined test dominates the comparable post-selection inference methods of Tibshirani et al. [JASA, 2016, 514, 600-620] and may surpass the power of established unit root tests against local alternatives. We apply the new tests to groundwater level time series for Germany and find evidence rejecting stochastic trends to explain observed long-term declines in mean water levels., Comment: 59 pages, 9 figures (colour)

We present a Rabi-type measurement of two ground-state hydrogen hyperfine transitions performed in two opposite external magnetic field directions. This puts first constraints at the level of 2.3 10^-21 GeV on a set of coefficients of the Standard Model Extension, which were not measured by previous experiments. Moreover, we introduce a novel method, applicable to antihydrogen hyperfine spectroscopy in a beam, that determines the zero-field hyperfine transition frequency from the two transitions measured at the same magnetic field. Our value, nu_0 = 1.420 405 751 63(63) GHz, is in agreement with literature at a relative precision of 0.44 ppb. This is the highest precision achieved on hydrogen in a beam, improving over previous results by a factor of 6., Comment: 8 pages, 5 figures, 2 tables, corresponding author: chloe.m@cern.ch (C. Malbrunot)

Carbon-based black pigments, a widely used class of pigments, are difficult to differentiate with the noninvasive techniques currently used in cultural heritage science. We utilize pump-probe microscopy to distinguish four common carbon-based black pigments as pure pigments, as two-component black pigment mixtures, and as a mixture of a black and a colorful pigment. This work also demonstrates that even nominally homogeneous pigments present remarkable, and useful, heterogeneity in pump-probe microscopy.

Black-hole X-ray binaries exhibit different spectral and timing properties in different accretion states. The X-ray outburst of a recently discovered and extraordinarily bright source, Swift$~$J1727.8$-$1613, has enabled the first investigation of how the X-ray polarization properties of a source evolve with spectral state. The 2$-$8 keV polarization degree was previously measured by the Imaging X-ray Polarimetry Explorer (IXPE) to be $\approx$ 4% in the hard and hard intermediate states. Here we present new IXPE results taken in the soft state, with the X-ray flux dominated by the thermal accretion-disk emission. We find that the polarization degree has dropped dramatically to $\lesssim$ 1%. This result indicates that the measured X-ray polarization is largely sensitive to the accretion state and the polarization fraction is significantly higher in the hard state when the X-ray emission is dominated by up-scattered radiation in the X-ray corona. The combined polarization measurements in the soft and hard states disfavor a very high or low inclination of the system., Comment: 9 pages, 7 figures

In optical experiments, shutters are devices that open or close a path of light. They are often used to limit the duration of light exposure onto a target or onto a detector in order to reduce possible light-induced damage. Many commercial shutters are available for different applications - some provide very fast opening and closing times, some can handle large optical powers, and others allow for fail-safe operation. Many of these devices are costly and offer limited control options. Here we provide an open-source design for a low-cost, general purpose shutter system based on ubiquitous servo motors that are connected to an Arduino-based controller. Several shutters can be controlled by one controller, further reducing system cost. The state of the shutters can be controlled via a display built into the controller, by serial commands via USB, or by electrical control lines. The use of a microcontroller makes the shutter controller adaptable - only control options that are used need to be included, and the design accommodates a selection of display and servo options. We provide designs for all required components, including 3D print files for the servo holders and cases, software for the Arduino, libraries for serial communication (C and python), and example graphical user interfaces for testing.

We propose a novel approach to elicit the weight of a potentially non-stationary regressor in the consistent and oracle-efficient estimation of autoregressive models using the adaptive Lasso. The enhanced weight builds on a statistic that exploits distinct orders in probability of the OLS estimator in time series regressions when the degree of integration differs. We provide theoretical results on the benefit of our approach for detecting stationarity when a tuning criterion selects the $\ell_1$ penalty parameter. Monte Carlo evidence shows that our proposal is superior to using OLS-based weights, as suggested by Kock [Econom. Theory, 32, 2016, 243-259]. We apply the modified estimator to model selection for German inflation rates after the introduction of the Euro. The results indicate that energy commodity price inflation and headline inflation are best described by stationary autoregressions., Comment: 63 pages, 9 figures

We report on X-ray polarization measurements of the extra-galactic Crab-like PSR B0540-69 and its Pulsar Wind Nebula (PWN) in the Large Magellanic Cloud (LMC), using a ~850 ks Imaging X-ray Polarimetry Explorer (IXPE) exposure. The PWN is unresolved by IXPE. No statistically significant polarization is detected for the image-averaged data, giving a 99% confidence polarization upper limit (MDP99) of 5.3% in 2-8 keV energy range. However, a phase-resolved analysis detects polarization for both the nebula and pulsar in the 4-6 keV energy range. For the PWN defined as the off-pulse phases, the polarization degree (PD) of (24.5 ${\pm}$ 5.3)% and polarization angle (PA) of (78.1 ${\pm}$ 6.2){\deg} is detected at 4.6${\sigma}$ significance level, consistent with the PA observed in the optical band. In a single on-pulse window, a hint of polarization is measured at 3.8${\sigma}$ with polarization degree of (50.0 ${\pm}$ 13.1)% and polarization angle of (6.2 ${\pm}$ 7.4){\deg}. A 'simultaneous' PSR/PWN analysis finds two bins at the edges of the pulse exceeding 3${\sigma}$ PD significance, with PD of (68 ${\pm}$ 20)% and (62 ${\pm}$ 20)%; intervening bins at 2-3${\sigma}$ significance have lower PD, hinting at additional polarization structure., Comment: 10 pages, 7 figures, 4 tables, author's version of the paper accepted for publication in ApJ

Prompt photons are created in the early stages of heavy ion collisions and traverse the QGP medium without any interaction. Therefore, photon-triggered jets can be used to study the jet quenching in the QGP medium. In this work, photon-triggered jets are studied through different jet and jet substructure observables for different collision systems and energies using the JETSCAPE framework. Since the multistage evolution used in the JETSCAPE framework is adequate to describe a wide range of experimental observables simultaneously using the same parameter tune, we use the same parameters tuned for jet and leading hadron studies. The same isolation criteria used in the experimental analysis are used to identify prompt photons for better comparison. For the first time, high-accuracy JETSCAPE results are compared with multi-energy LHC and RHIC measurements to better understand the deviations observed in prior studies. This study highlights the importance of multistage evolution for the simultaneous description of experimental observables through different collision systems and energies using a single parameter tune., Comment: 4 pages, 5 figures. Proceedings of Quark Matter 2023 - XXXth International Conference on Ultra-relativistic Nucleus-Nucleus Collisions, Houston, TX, 3-9 September 2023

Weakly magnetized neutron stars in X-ray binaries show complex phenomenology with several spectral components that can be associated with the accretion disk, boundary and/or spreading layer, a corona, and a wind. Spectroscopic information alone is, however, not enough to disentangle these components. Additional information about the nature of the spectral components and in particular the geometry of the emission region can be provided by X-ray polarimetry. One of the objects of the class, a bright, persistent, and rather peculiar galactic Type I X-ray burster was observed with the Imaging X-ray Polarimetry Explorer (IXPE) and the X-ray Multi-Mirror Mission Newton (XMM-Newton). Using the XMM-Newton data we estimated the current state of the source as well as detected strong absorption lines associated with the accretion disk wind. IXPE data showed the source to be significantly polarized in the 2-8 keV energy band with the overall polarization degree (PD) of 1.4% at a polarization angle (PA) of -2 degrees (errors at 68% confidence level). During the two-day long observation, we detected rotation of the PA by about 70 degrees with the corresponding changes in the PD from 2% to non-detectable and then up to 5%. These variations in polarization properties are not accompanied by visible changes in spectroscopic characteristics. The energy-resolved polarimetric analysis showed a significant change in polarization, from being strongly dependent on energy at the beginning of the observation to being almost constant with energy in the later parts of the observation. As a possible interpretation, we suggest the presence of a constant component of polarization, strong wind scattering, or different polarization of the two main spectral components with individually peculiar behavior. The rotation of the PA suggests a 30-degree misalignment of the neutron star spin from the orbital axis., Comment: 12 pages, 12 figures, submitted to A&A

Observations of linear polarization in the 2-8 keV energy range with the Imaging X-ray Polarimetry Explorer (IXPE) explore the magnetic field geometry and dynamics of the regions generating non-thermal radiation in relativistic jets of blazars. These jets, particularly in blazars whose spectral energy distribution peaks at X-ray energies, emit X-rays via synchrotron radiation from high-energy particles within the jet. IXPE observations of the X-ray selected BL Lac-type blazar 1ES 1959+650 in 2022 May 3-4 showed a significant linear polarization degree of $\Pi_\mathrm{x} = 8.0\% \pm 2.3\%$ at an electric-vector position angle $\psi_\mathrm{x} = 123^\circ \pm 8^\circ$. However, in 2022 June 9-12, only an upper limit of $\Pi_\mathrm{x} \leq 5.1\%$ could be derived (at the 99% confidence level). The degree of optical polarization at that time $\Pi_\mathrm{O} \sim 5\%$ is comparable to the X-ray measurement. We investigate possible scenarios for these findings, including temporal and geometrical depolarization effects. Unlike some other X-ray selected BL Lac objects, there is no significant chromatic dependence of the measured polarization in 1ES 1959+650, and its low X-ray polarization may be attributed to turbulence in the jet flow with dynamical timescales shorter than 1 day., Comment: 16 pages, 4 figures, accepted for publication in The Astrophysical Journal

The JETSCAPE Collaboration reports the first multi-messenger study of the QGP jet transport parameter $\hat{q}$ using Bayesian inference, incorporating all available hadron and jet inclusive yield and jet substructure data from RHIC and the LHC. The theoretical model utilizes virtuality-dependent in-medium partonic energy loss coupled to a detailed dynamical model of QGP evolution. Tension is observed when constraining $\hat{q}$ for different kinematic cuts of the inclusive hadron data. The addition of substructure data is shown to improve the constraint on $\hat{q}$, without inducing tension with the constraint due to inclusive observables. These studies provide new insight into the mechanisms of jet interactions in matter, and point to next steps in the field for comprehensive understanding of jet quenching as a probe of the QGP., Comment: 4 pages, 2 figures. Proceedings of Quark Matter 2023 - XXXth International Conference on Ultra-relativistic Nucleus-Nucleus Collisions, Houston, TX, 3-9 September 2023

We present the first X-ray polarimetric study of the dipping accreting neutron star 4U 1624$-$49 with the Imaging X-ray Polarimetry Explorer (IXPE). We report a detection of polarization in the non-dip time intervals with a confidence level of 99.99%. We find an average polarization degree (PD) of $3.1\pm0.7$% and a polarization angle of $81\pm6$ degrees east of north in the 2-8 keV band. We report an upper limit on the PD of 22% during the X-ray dips with 95% confidence. The PD increases with energy, reaching from $3.0\pm0.9$% in the 4-6 keV band to $6\pm2$% in the 6-8 keV band. This indicates the polarization likely arises from Comptonization. The high PD observed is unlikely to be produced by Comptonization in the boundary layer or spreading layer alone. It can be produced by the addition of an extended geometrically thin slab corona covering part of the accretion disk, as assumed in previous models of dippers, and/or a reflection component from the accretion disk.

Identifying disease phenotypes from electronic health records (EHRs) is critical for numerous secondary uses. Manually encoding physician knowledge into rules is particularly challenging for rare diseases due to inadequate EHR coding, necessitating review of clinical notes. Large language models (LLMs) offer promise in text understanding but may not efficiently handle real-world clinical documentation. We propose a zero-shot LLM-based method enriched by retrieval-augmented generation and MapReduce, which pre-identifies disease-related text snippets to be used in parallel as queries for the LLM to establish diagnosis. We show that this method as applied to pulmonary hypertension (PH), a rare disease characterized by elevated arterial pressures in the lungs, significantly outperforms physician logic rules ($F_1$ score of 0.62 vs. 0.75). This method has the potential to enhance rare disease cohort identification, expanding the scope of robust clinical research and care gap identification., Comment: Deep Generative Models for Health Workshop NeurIPS 2023

We report the discovery of X-ray polarization from the X-ray-bright filament. G0.13-0.11 in the Galactic center (GC) region. This filament features a bright, hard X-ray source that is most plausibly a pulsar wind nebula (PWN) and an extended and structured diffuse component. Combining the polarization signal from IXPE with the imaging/spectroscopic data from Chandra, we find that X-ray emission of G0.13-0.11 is highly polarized PD=$57(\pm18)$% in the 3-6 keV band, while the polarization angle is PA=$21^\circ(\pm9^\circ)$. This high degree of polarization proves the synchrotron origin of the X-ray emission from G0.13-0.11. In turn, the measured polarization angle implies that the X-ray emission is polarized approximately perpendicular to a sequence of nonthermal radio filaments that may be part of the GC Radio Arc. The magnetic field on the order of $100\,{\rm\mu G}$ appears to be preferentially ordered along the filaments. The above field strength is the fiducial value that makes our model self-consistent, while the other conclusions are largely model independent., Comment: Accepted for publication in A&A

In this paper, we present a full spatially resolved polarization map for the Vela Pulsar Wind Nebula (PWN) observed by IXPE. By employing effective background discrimination techniques, our results show a remarkably high degree of local polarization in the outskirt region, exceeding 60% (55%) with a probability of 95% (99%), which approaches the upper limit predicted by the synchrotron emission mechanism. The high degree of polarization suggests that the turbulent magnetic energy is at most 33% of the ordered one. In addition, the X-ray polarization map exhibits a toroidal magnetic field pattern that is consistent with the field revealed by radio observations across the entire nebula. This consistency reveals that the observed X-ray and radio emissions are radiated by electrons from the same magnetic field. Different from the Crab PWN, the consistency observed in the Vela PWN may be attributed to the interaction between the reverse shock of supernova blast wave and the PWN, which leads to a displacement between the synchrotron-cooled nebula and the fresh nebula close to the pulsar. These findings deepen our understanding of the structure and evolution of the Vela PWN, and the magnetohydrodynamic interaction in PWNe., Comment: Accepted by ApJL

Large language models, sometimes referred to as foundation models, have transformed multiple fields of research. However, smaller languages risk falling behind due to high training costs and small incentives for large companies to train these models. To combat this, the Danish Foundation Models project seeks to provide and maintain open, well-documented, and high-quality foundation models for the Danish language. This is achieved through broad cooperation with public and private institutions, to ensure high data quality and applicability of the trained models. We present the motivation of the project, the current status, and future perspectives., Comment: 4 pages, 2 tables

The Imaging X-ray Polarimetry Explorer (IXPE) measured with high significance the X-ray polarization of the brightest Z-source Scorpius X-1, resulting in the nominal 2-8 keV energy band in a polarization degree of 1.0(0.2)% and a polarization angle of 8(6){\deg} at 90% of confidence level. This observation was strictly simultaneous with observations performed by NICER, NuSTAR, and Insight-HXMT, which allowed for a precise characterization of its broad-band spectrum from soft to hard X-rays. The source has been observed mainly in its soft state, with short periods of flaring. We also observed low-frequency quasi-periodic oscillations. From a spectro-polarimetric analysis, we associate a polarization to the accretion disk at <3.2% at 90% of confidence level, compatible with expectations for an electron-scattering dominated optically thick atmosphere at the Sco X-1 inclination of 44{\deg}; for the higher-energy Comptonized component, we obtain a polarization of 1.3(0.4)%, in agreement with expectations for a slab of Thomson optical depth of ~7 and an electron temperature of ~3 keV. A polarization rotation with respect to previous observations by OSO-8 and PolarLight, and also with respect to the radio-jet position angle, is observed. This result may indicate a variation of the polarization with the source state that can be related to relativistic precession or to a change in the corona geometry with the accretion flow.

We report on an observational campaign on the bright black hole X-ray binary Swift J1727.8$-$1613 centered around five observations by the Imaging X-ray Polarimetry Explorer (IXPE). These observations track for the first time the evolution of the X-ray polarization of a black hole X-ray binary across a hard to soft state transition. The 2--8 keV polarization degree decreased from $\sim$4\% to $\sim$3\% across the five observations, but the polarization angle remained oriented in the North-South direction throughout. Based on observations with the Australia Telescope Compact Array (ATCA), we find that the intrinsic 7.25 GHz radio polarization aligns with the X-ray polarization. Assuming the radio polarization aligns with the jet direction (which can be tested in the future with higher spatial resolution images of the jet), our results imply that the X-ray corona is extended in the disk plane, rather than along the jet axis, for the entire hard intermediate state. This in turn implies that the long ($\gtrsim$10 ms) soft lags that we measure with the Neutron star Interior Composition ExploreR (NICER) are dominated by processes other than pure light-crossing delays. Moreover, we find that the evolution of the soft lag amplitude with spectral state does not follow the trend seen for other sources, implying that Swift J1727.8$-$1613 is a member of a hitherto under-sampled sub-population., Comment: Accepted for publication in ApJ. 21 pages, 8 figures

Cir X-1 is a neutron star X-ray binary characterized by strong variations in flux during its eccentric $\sim$16.6 days orbit. There are also strong variations in the spectral state, and historically it has shown both atoll and Z state properties. We observed the source with the Imaging X-ray Polarimetry Explorer during two orbital segments, 6 days apart, for a total of 263~ks. We find an X-ray polarization degree in these segments of $1.6\%\pm0.3\%$ and $1.4\%\pm0.3\%$ at polarization angles of $37^\circ\pm5^\circ$ and $-12^\circ\pm7^\circ$, respectively. Thus we observed a rotation of the polarization angle by $49^\circ\pm8^\circ$ along the orbit. Because variations of accretion flow, and then of the hardness ratio, are expected during the orbit, we also studied the polarization binned in hardness ratio, and found the polarization angle differing by $67^\circ\pm11^\circ$ between the lowest and highest values of the hardness ratio. We discuss possible interpretations of this result that could indicate a possible misalignment between the symmetry axes of the accretion disk and the Comptonizing region caused by the misalignment of the neutron star's angular momentum with respect to the orbital one., Comment: 15 pages, 6 figures, Accepted for publication in ApJL

In an accreting X-ray pulsar, a neutron star accretes matter from a stellar companion through an accretion disk. The high magnetic field of the rotating neutron star disrupts the inner edge of the disc, funneling the gas to flow onto the magnetic poles on its surface. Hercules X-1 is in many ways the prototypical X-ray pulsar; it shows persistent X-ray emission and it resides with its companion HZ Her, a two-solar-mass star, at about 7~kpc from Earth. Its emission varies on three distinct timescales: the neutron star rotates every 1.2~seconds, it is eclipsed by its companion each 1.7~days, and the system exhibits a superorbital period of 35~days which has remained remarkably stable since its discovery. Several lines of evidence point to the source of this variation as the precession of the accretion disc, the precession of the neutron star or both. Despite the many hints over the past fifty years, the precession of the neutron star itself has yet not been confirmed or refuted. We here present X-ray polarization measurements with the Imaging X-ray Polarimetry Explorer (IXPE) which probe the spin geometry of the neutron star. These observations provide direct evidence that the 35-day-period is set by the free precession of the neutron star crust, which has the important implication that its crust is somewhat asymmetric fractionally by a few parts per ten million. Furthermore, we find indications that the basic spin geometry of the neutron star is altered by torques on timescale of a few hundred days., Comment: 37 pages

We report on IXPE, NICER and XMM-Newton observations of the magnetar 1E 2259+586. We find that the source is significantly polarized at about or above 20% for all phases except for the secondary peak where it is more weakly polarized. The polarization degree is strongest during the primary minimum which is also the phase where an absorption feature has been identified previously (Pizzocaro et al. 2019). The polarization angle of the photons are consistent with a rotating vector model with a mode switch between the primary minimum and the rest of the rotation of the neutron star. We propose a scenario in which the emission at the source is weakly polarized (as in a condensed surface) and, as the radiation passes through a plasma arch, resonant cyclotron scattering off of protons produces the observed polarized radiation. This confirms the magnetar nature of the source with a surface field greater than about 1015 G, Comment: 13 pages, 13 figures, 5 tables

Cadmium sulfide (CdS) pigments have degraded in several well-known paintings, but the mechanisms of degradation have yet to be fully understood. Traditional non-destructive analysis techniques primarily focus on macroscopic degradation, whereas microscopic information is typically obtained with invasive techniques that require sample removal. Here, we demonstrate the use of pump-probe microscopy to nondestructively visualize the three-dimensional structure and degradation progress of CdS pigments in oil paints. CdS pigments, reproduced following historical synthesis methods, were artificially aged by exposure to high relative humidity (RH) and ultraviolet (UV) light. Pump-probe microscopy was applied to track the degradation progress in single grains, and volumetric imaging revealed early CdS degradation of small particles and on the surface of large particles. This indicates that the particle dimension influences the extent and evolution of degradation of historical CdS. In addition, the pump-probe signal decrease in degraded CdS is observable before visible changes to the eye, demonstrating that pump-probe microscopy is a promising tool to detect early-stage degradation in artworks. The observed degradation by pump-probe microscopy occurred through the conversion from CdS into CdSO4.xH2O, verified by both FTIR (Fourier-transform infrared) and XPS (X-ray photoelectron spectroscopy) experiment.

We present X-ray polarimetry observations from the Imaging X-ray Polarimetry Explorer (IXPE) of three low spectral peak and one intermediate spectral peak blazars, namely 3C 273, 3C 279, 3C 454.3, and S5 0716+714. For none of these objects was IXPE able to detect X-ray polarization at the 3$\sigma$ level. However, we placed upper limits on the polarization degree at $\sim$10-30\%. The undetected polarizations favor models where the X-ray band is dominated by unpolarized photons upscattered by relativistic electrons in the jets of blazars, although hadronic models are not completely eliminated. We discuss the X-ray polarization upper limits in the context of our contemporaneous multiwavelength polarization campaigns., Comment: 19 pages, 10 figures, 6 tables; submitted to the Astrophysical Journal

Observing a supernova explosion shortly after it occurs can reveal important information about the physics of stellar explosions and the nature of the progenitor stars of supernovae (SNe). When a star with a well-defined edge explodes in vacuum, the first photons to escape from its surface appear as a brief shock-breakout flare. The duration of this flare can extend to at most a few hours even for nonspherical breakouts from supergiant stars, after which the explosion ejecta should expand and cool. Alternatively, for stars exploding within a distribution of sufficiently dense optically thick circumstellar material, the first photons escape from the material beyond the stellar edge, and the duration of the initial flare can extend to several days, during which the escaping emission indicates photospheric heating. The difficulty in detecting SN explosions promptly after the event has so far limited data regarding supergiant stellar explosions mostly to serendipitous observations that, owing to the lack of ultraviolet (UV) data, were unable to determine whether the early emission is heating or cooling, and hence the nature of the early explosion event. Here, we report observations of SN 2023ixf in the nearby galaxy M101, covering the early days of the event. Using UV spectroscopy from the Hubble Space Telescope (HST) as well as a comprehensive set of additional multiwavelength observations, we trace the photometric and spectroscopic evolution of the event and are able to temporally resolve the emergence and evolution of the SN emission.

On 22 September 2023 the inauguration of the "Stachelsch\"utzenhaus" at Basel's Petersplatz (St. Peter's Square) as an EPS Historic Site was hosted by the University of Basel. In the following article we will focus first on Daniel Bernoulli's career path, before discussing his major scientific achievements and finally adding some aspects of the inauguration ceremony (the colloquium talks, the visit of today's laboratories in the Stachelsch\"utzenhaus, and the unveiling of the plaque)., Comment: 7 pages, 14 figures, to appear in SPS Communications No.71 of the Swiss Physical Society

Microsatellite instability-high (MSI-H) is a tumor agnostic biomarker for immune checkpoint inhibitor therapy. However, MSI status is not routinely tested in prostate cancer, in part due to low prevalence and assay cost. As such, prediction of MSI status from hematoxylin and eosin (H&E) stained whole-slide images (WSIs) could identify prostate cancer patients most likely to benefit from confirmatory testing and becoming eligible for immunotherapy. Prostate biopsies and surgical resections from de-identified records of consecutive prostate cancer patients referred to our institution were analyzed. Their MSI status was determined by next generation sequencing. Patients before a cutoff date were split into an algorithm development set (n=4015, MSI-H 1.8%) and a paired validation set (n=173, MSI-H 19.7%) that consisted of two serial sections from each sample, one stained and scanned internally and the other at an external site. Patients after the cutoff date formed the temporal validation set (n=1350, MSI-H 2.3%). Attention-based multiple instance learning models were trained to predict MSI-H from H&E WSIs. The MSI-H predictor achieved area under the receiver operating characteristic curve values of 0.78 (95% CI [0.69-0.86]), 0.72 (95% CI [0.63-0.81]), and 0.72 (95% CI [0.62-0.82]) on the internally prepared, externally prepared, and temporal validation sets, respectively. While MSI-H status is significantly correlated with Gleason score, the model remained predictive within each Gleason score subgroup. In summary, we developed and validated an AI-based MSI-H diagnostic model on a large real-world cohort of routine H&E slides, which effectively generalized to externally stained and scanned samples and a temporally independent validation cohort. This algorithm has the potential to direct prostate cancer patients toward immunotherapy and to identify MSI-H cases secondary to Lynch syndrome.

MET protein overexpression is a targetable event in non-small cell lung cancer (NSCLC) and is the subject of active drug development. Challenges in identifying patients for these therapies include lack of access to validated testing, such as standardized immunohistochemistry (IHC) assessment, and consumption of valuable tissue for a single gene/protein assay. Development of pre-screening algorithms using routinely available digitized hematoxylin and eosin (H&E)-stained slides to predict MET overexpression could promote testing for those who will benefit most. While assessment of MET expression using IHC is currently not routinely performed in NSCLC, next-generation sequencing is common and in some cases includes RNA expression panel testing. In this work, we leveraged a large database of matched H&E slides and RNA expression data to train a weakly supervised model to predict MET RNA overexpression directly from H&E images. This model was evaluated on an independent holdout test set of 300 over-expressed and 289 normal patients, demonstrating an ROC-AUC of 0.70 (95th percentile interval: 0.66 - 0.74) with stable performance characteristics across different patient clinical variables and robust to synthetic noise on the test set. These results suggest that H&E-based predictive models could be useful to prioritize patients for confirmatory testing of MET protein or MET gene expression status.

We report on the coordinated observations of the neutron star low-mass X-ray binary (NS-LMXB) \gx in X-rays (IXPE, NICER, Nustar and INTEGRAL), optical (REM and LCO), near-infrared (REM), mid-infrared (VLT VISIR), and radio (ATCA). This Z-source was observed by \IXPE twice in March-April 2023 (Obs. 1 and 2). In the radio band, the source was detected, but only upper-limits to the linear polarization were obtained at a $3\sigma$ level of $6.1\%$ at 5.5 GHz and $5.9\%$ at 9 GHz in Obs.~1 and $12.5\%$ at 5.5~GHz and $20\%$ at 9~GHz in Obs.~2. The mid-IR, near-IR and optical observations suggest the presence of a compact jet which peaks in the mid- or far-IR. The X-ray polarization degree was found to be $3.7\% \pm 0.4 \%$ (at $90\%$ confidence level) during Obs.~1 when the source was in the horizontal branch of the Z-track and $1.8\% \pm 0.4 \%$ during Obs.~2 when the source was in the normal-flaring branch. These results confirm the variation of polarization degree as a function of the position of the source in the color-color diagram as for previously observed Z-track sources (Cyg~X-2 and XTE~1701$-$462). Evidence for a variation of the polarization angle $\sim 20^\circ$ with energy is found in both observations, likely related to the different, non-orthogonal polarization angles of the disk and Comptonization components which peak at different energies., Comment: Submitted to Astronomy and Astrophysics on 06 July 2023. Accepted on 21 November 2023

We conducted a polarimetry campaign from radio to X-ray wavelengths of the high-synchrotron-peak (HSP) blazar Mrk 421, including Imaging X-ray Polarimetry Explorer (IXPE) measurements on 2022 December 6-8. We detected X-ray polarization of Mrk 421 with a degree of $\Pi_{\rm X}$=14$\pm$1$\%$ and an electric-vector position angle $\psi_{\rm X}$=107$\pm$3$^{\circ}$ in the 2-8 keV band. From the time variability analysis, we find a significant episodic variation in $\psi_{\rm X}$. During 7 months from the first IXPE pointing of Mrk 421 in 2022 May, $\psi_{\rm X}$ varied across the range of 0$^{\circ}$ to 180$^{\circ}$, while $\Pi_{\rm X}$ maintained similar values within $\sim$10-15$\%$. Furthermore, a swing in $\psi_{\rm X}$ in 2022 June was accompanied by simultaneous spectral variations. The results of the multiwavelength polarimetry show that the X-ray polarization degree was generally $\sim$2-3 times greater than that at longer wavelengths, while the polarization angle fluctuated. Additionally, based on radio, infrared, and optical polarimetry, we find that rotation of $\psi$ occurred in the opposite direction with respect to the rotation of $\psi_{\rm X}$ over longer timescales at similar epochs. The polarization behavior observed across multiple wavelengths is consistent with previous IXPE findings for HSP blazars. This result favors the energy-stratified shock model developed to explain variable emission in relativistic jets. The accompanying spectral variation during the $\psi_{\rm X}$ rotation can be explained by a fluctuation in the physical conditions, e.g., in the energy distribution of relativistic electrons. The opposite rotation direction of $\psi$ between the X-ray and longer-wavelength polarization accentuates the conclusion that the X-ray emitting region is spatially separated from that at longer wavelengths., Comment: 17 pages, 13 figures, 4 tables; Accepted for publication in A&A

We present polarization measurements in the $2-8 \thinspace \mathrm{keV}$ band from blazar 1ES 0229+200, the first extreme high synchrotron peaked source to be observed by the Imaging X-ray Polarimetry Explorer (IXPE). Combining two exposures separated by about two weeks, we find the degree of polarization to be $\Pi_{X} = 17.9 \pm 2.8 \%$ at an electric-vector position angle $\psi_X = 25.0 \pm 4.6^{\circ}$ using a spectropolarimetric fit from joint IXPE and XMM-Newton observations. There is no evidence for the polarization degree or angle varying significantly with energy or time on both short time scales (hours) or longer time scales (days). The contemporaneous polarization degree at optical wavelengths was $>$7$\times$ lower, making 1ES 0229+200 the most strongly chromatic blazar yet observed. This high X-ray polarization compared to the optical provides further support that X-ray emission in high-peaked blazars originates in shock-accelerated, energy-stratified electron populations, but is in tension with many recent modeling efforts attempting to reproduce the spectral energy distribution of 1ES 0229+200 which attribute the extremely high energy synchrotron and Compton peaks to Fermi acceleration in the vicinity of strongly turbulent magnetic fields., Comment: 17 Pages, 6 Figures, Resubmitted to ApJ after addressing referee comments