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Your search keyword '"Martin, Gaelle H."' showing total 8 results
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8 results on '"Martin, Gaelle H."'

2. VISTA is an acidic pH-selective ligand for PSGL-1

Author

Johnston, Robert J., Su, Linhui Julie, Pinckney, Jason, Critton, David, Boyer, Eric, Krishnakumar, Arathi, Corbett, Martin, Rankin, Andrew L., Dibella, Rose, Campbell, Lynne, Martin, Gaelle H., Lemar, Hadia, Cayton, Thomas, Huang, Richard Y.-C., Deng, Xiaodi, Nayeem, Akbar, Chen, Haibin, Ergel, Burce, Rizzo, Joseph M., Yamniuk, Aaron P., Dutta, Sanjib, Ngo, Justine, Shorts, Andrea Olga, Ramakrishnan, Radha, Kozhich, Alexander, Holloway, Jim, Fang, Hua, Wang, Ying-Kai, Yang, Zheng, Thiam, Kader, Rakestraw, Ginger, Rajpal, Arvind, Sheppard, Paul, Quigley, Michael, Bahjat, Keith S., and Korman, Alan J.

Published
2019
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5. Pathogenic T cells have a paradoxical protective effect in murine autoimmune diabetes by boosting Tregs

Author

Grinberg-Bleyer, Yenkel, Saadoun, David, Baeyens, Audrey, Billiard, Fabienne, Goldstein, Jeremie D., Gregoire, Sylvie, Martin, Gaelle H., Elhage, Rima, Derian, Nicolas, Carpentier, Wassila, Marodon, Gilles, Klatzmann, David, Piaggio, Eliane, and Salomon, Benoit L.

Subjects
T cells -- Properties, Autoimmunity -- Physiological aspects, Diabetes -- Physiological aspects -- Care and treatment, Health care industry
Abstract

[CD4.sup.+][CD25.sup.+][Foxp3.sup.+] Tregs play a major role in prevention of autoimmune diseases. The suppressive effect of Tregs on effector T cells (Teffs), the cells that can mediate autoimmunity, has been extensively studied. However, the in vivo impact of Teff activation on Tregs during autoimmunity has not been explored. In this study, we have shown that [CD4.sup.+] Teff activation strongly boosts the expansion and suppressive activity of Tregs. This helper function of [CD4.sup.+] T cells, which we believe to be novel, was observed in the pancreas and draining lymph nodes in mouse recipients of islet-specific Teffs and Tregs. Its physiological impact was assessed in autoimmune diabetes. When islet-specific Teffs were transferred alone, they induced diabetes. Paradoxically, when the same Teffs were cotransferred with islet-specific Tregs, they induced disease protection by boosting Treg expansion and suppressive function. RNA microarray analyses suggested that TNF family members were involved in the Teff-mediated Treg boost. In vivo experiments showed that this Treg boost was partially dependent on TNF but not on IL-2. This feedback regulatory loop between Teffs and Tregs may be critical to preventing or limiting the development of autoimmune diseases., Introduction The peripheral T cell repertoire of any individual contains autoreactive T cells specific for a variety of self antigens (1). Their activation could induce an autoimmune process, eventually leading [...]

Published
2010
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6. Unique Regulatory Pathways Dictate the Translational Program in Hematopoietic Stem and Progenitor Cells

Author

Elias, Harold K., primary, Spevak, Christina, additional, Kannan, Lavanya, additional, Ali, Mohamed A.E., additional, Martin, Gaelle H, additional, Selvaraj, Shanmugapriya, additional, Eng, William S, additional, Zhao, Guangjie, additional, Ernlund, Amanda, additional, Rajasekhar, Vinagolu, additional, Woolthuis, Carolien M, additional, Schneider, Robert J, additional, and Park, Christopher Y., additional

Published
2019
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7. Treatment of Uveitis by In Situ Administration of Ex Vivo–Activated Polyclonal Regulatory T Cells

Author

Grégoire, Sylvie, primary, Terrada, Céline, additional, Martin, Gaelle H., additional, Fourcade, Gwladys, additional, Baeyens, Audrey, additional, Marodon, Gilles, additional, Fisson, Sylvain, additional, Billiard, Fabienne, additional, Lucas, Bruno, additional, Tadayoni, Ramin, additional, Béhar-Cohen, Francine, additional, Levacher, Béatrice, additional, Galy, Anne, additional, LeHoang, Phuc, additional, Klatzmann, David, additional, Bodaghi, Bahram, additional, and Salomon, Benoît L., additional

Published
2016
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