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1. Assessing the efficacy and tolerability of PET-guided BrECADD versus eBEACOPP in advanced-stage, classical Hodgkin lymphoma (HD21): a randomised, multicentre, parallel, open-label, phase 3 trial

Author

Borchmann, Peter, Ferdinandus, Justin, Schneider, Gundolf, Moccia, Alden, Greil, Richard, Hertzberg, Mark, Schaub, Valdete, Hüttmann, Andreas, Keil, Felix, Dierlamm, Judith, Hänel, Mathias, Novak, Urban, Meissner, Julia, Zimmermann, Andreas, Mathas, Stephan, Zijlstra, Josée M, Fosså, Alexander, Viardot, Andreas, Hertenstein, Bernd, Martin, Sonja, Giri, Pratyush, Scholl, Sebastian, Topp, Max S, Jung, Wolfram, Vucinic, Vladan, Beck, Hans-Joachim, Kerkhoff, Andrea, Unger, Benjamin, Rank, Andreas, Schroers, Roland, zum Büschenfelde, Christian Meyer, de Wit, Maike, Trautmann-Grill, Karolin, Kamper, Peter, Molin, Daniel, Kreissl, Stefanie, Kaul, Helen, von Tresckow, Bastian, Borchmann, Sven, Behringer, Karolin, Fuchs, Michael, Rosenwald, Andreas, Klapper, Wolfram, Eich, Hans-Theodor, Baues, Christian, Zomas, Athanasios, Hallek, Michael, Dietlein, Markus, Kobe, Carsten, and Diehl, Volker

Published
2024
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2. Risk factors for Nocardia infection among allogeneic hematopoietic cell transplant recipients: A case-control study of the Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation

Author

De Greef, Julien, Averbuch, Dina, Tondeur, Laura, Duréault, Amélie, Zuckerman, Tsila, Roussel, Xavier, Robin, Christine, Xhaard, Alienor, Pagliuca, Simona, Beguin, Yves, Botella-Garcia, Carmen, Khanna, Nina, Le Bourgeois, Amandine, Van Praet, Jens, Ho, Aloysius, Kröger, Nicolaus, Ducastelle Leprêtre, Sophie, Roos-Weil, Damien, Aljurf, Mahmoud, Blijlevens, Nicole, Blau, Igor Wolfgang, Carlson, Kristina, Collin, Matthew, Ganser, Arnold, Villate, Alban, Lakner, Johannes, Martin, Sonja, Nagler, Arnon, Ram, Ron, Torrent, Anna, Stamouli, Maria, Mikulska, Malgorzata, Gil, Lidia, Wendel, Lotus, Tridello, Gloria, Knelange, Nina, de la Camara, Rafael, Lortholary, Olivier, Fontanet, Arnaud, Styczynski, Jan, Maertens, Johan, Coussement, Julien, and Lebeaux, David

Published
2024
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3. Remission induction versus immediate allogeneic haematopoietic stem cell transplantation for patients with relapsed or poor responsive acute myeloid leukaemia (ASAP): a randomised, open-label, phase 3, non-inferiority trial

Author

Alakel, Nael, Albring, Jörn, Berdel, Wolfgang E., Bethge, Wolfgang, Bornhäuser, Martin, Bug, Gesine, Buhl, Christoph, Call, Simon, Crysandt, Martina, Egger-Heidrich, Katharina, Eßeling, Eva, Faul, Christoph, Franke, Georg-Nikolaus, Georgi, Julia-Annabell, Glück-Wolf, Julia, Groth, Christoph, Hauptrock, Beate, Heidenreich, Daniela, Janjetovic, Snjezana, Jost, Edgar, Kaufmann, Martin, Kindler, Thomas, Klein, Stefan A., Krause, Stefan W., Kreil, Sebastian, Kretschmann, Theresa, Kunadt, Desiree, Lang, Fabian, Lenz, Georg, Martin, Sonja, Marx, Julia, Middeke, Jan-Moritz, Mikesch, Jan-Henrik, Müller, Lutz P., Müller, Nadine, Niederland, Judith, Parmentier, Stefani, Petzold, Kathrin, Platzbecker, Uwe, Rank, Andreas, Reicherts, Christian, Röllig, Christoph, Rösler, Wolf, Schäfer-Eckart, Kerstin, Schaffrath, Judith, Schaich, Markus, Schetelig, Johannes, Schliemann, Christoph, Schmid, Christoph, Schneidawind, Dominik, Schubert, Jörg, Serve, Hubert, Sockel, Katja, Steffen, Björn, Stelljes, Matthias, Teipel, Raphael, von Bonin, Malte, Wagner-Drouet, Eva, Wass, Maxi, Wendelin, Knut, Middeke, Jan Moritz, Wagner-Drouet, Eva-Maria, Müller, Lutz P, Krause, Stefan W, Klein, Stefan A, Baldauf, Henning, Stölzel, Friedrich, Petzold, Cathleen, Kriege, Oliver, Berdel, Wolfgang E, Ehninger, Gerhard, and Schmidt, Alexander H

Published
2024
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4. Q-HAM: a multicenter upfront randomized phase II trial of quizartinib and high-dose Ara-C plus mitoxantrone in relapsed/refractory AML with FLT3-ITD

Author

Jaramillo, Sonia, Le Cornet, Lucian, Kratzmann, Markus, Krisam, Johannes, Görner, Martin, Hänel, Mathias, Röllig, Christoph, Wass, Maxi, Scholl, Sebastian, Ringhoffer, Mark, Reichart, Alexander, Steffen, Björn, Kayser, Sabine, Mikesch, Jan-Henrik, Schaefer-Eckart, Kerstin, Schubert, Jörg, Geer, Thomas, Martin, Sonja, Kieser, Meinhard, Sauer, Tim, Kriegsmann, Katharina, Hundemer, Michael, Serve, Hubert, Bornhäuser, Martin, Müller-Tidow, Carsten, and Schlenk, Richard F.

Published
2023
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5. Impact of the first COVID-19 lockdown in Germany on the rate of acute infections during intensive chemotherapy for Hodgkin lymphoma

Author

Jacob, Anne Sophie, Kaul, Helen, Fuchs, Michael, Gillessen, Sarah, Kreissl, Stefanie, Pluetschow, Annette, Momotow, Jesko, Schaub, Valdete, Huettmann, Andreas, Haenel, Mathias, Zimmermann, Andreas, Dierlamm, Judith, Meissner, Julia, Mathas, Stephan, Martin, Sonja, Engert, Andreas, Hallek, Michael, Borchmann, Peter, and Lehmann, Clara

Published
2022
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6. Prognostic value of a new clinically-based classification system in patients with CMML undergoing allogeneic HCT: a retrospective analysis of the EBMT-CMWP

Author

Onida, Francesco, Sbianchi, Giulia, Radujkovic, Aleksandar, Sockel, Katja, Kröger, Nicolaus, Sierra, Jorge, Socié, Gerard, Cornelissen, Jan, Poiré, Xavier, Raida, Luděk, Bourhis, Jean Henri, Finke, Jürgen, Passweg, Jakob, Salmenniemi, Urpu, Schouten, Harry C., Beguin, Yves, Martin, Sonja, Deconinck, Eric, Ganser, Arnold, Zver, Samo, Lioure, Bruno, Rohini, Radia, Koster, Linda, Hayden, Patrick, Iacobelli, Simona, Robin, Marie, and Yakoub-Agha, Ibrahim

Published
2022
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7. Mutations in ACTL6B Cause Neurodevelopmental Deficits and Epilepsy and Lead to Loss of Dendrites in Human Neurons.

Author

Bell, Scott, Rousseau, Justine, Peng, Huashan, Aouabed, Zahia, Priam, Pierre, Theroux, Jean-Francois, Jefri, Malvin, Tanti, Arnaud, Wu, Hanrong, Kolobova, Ilaria, Silviera, Heika, Manzano-Vargas, Karla, Ehresmann, Sophie, Hamdan, Fadi, Hettige, Nuwan, Zhang, Xin, Antonyan, Lilit, Nassif, Christina, Ghaloul-Gonzalez, Lina, Sebastian, Jessica, Vockley, Jerry, Begtrup, Amber, Wentzensen, Ingrid, Crunk, Amy, Nicholls, Robert, Deignan, Joshua, Al-Hertani, Walla, Efthymiou, Stephanie, Salpietro, Vincenzo, Miyake, Noriko, Makita, Yoshio, Matsumoto, Naomichi, Østern, Rune, Houge, Gunnar, Hafström, Maria, Fassi, Emily, Houlden, Henry, Klein Wassink-Ruiter, Jolien, Nelson, Dominic, Goldstein, Amy, Dabir, Tabib, van Gils, Julien, Bourgeron, Thomas, Delorme, Richard, Cooper, Gregory, Martinez, Jose, Finnila, Candice, Carmant, Lionel, Lortie, Anne, Oegema, Renske, van Gassen, Koen, Mehta, Sarju, Huhle, Dagmar, Abou Jamra, Rami, Martin, Sonja, Brunner, Han, Lindhout, Dick, Au, Margaret, Graham, John, Coubes, Christine, Turecki, Gustavo, Gravel, Simon, Mechawar, Naguib, Rossignol, Elsa, Michaud, Jacques, Lessard, Julie, Ernst, Carl, Campeau, Philippe, and Herman, Kristin

Subjects
ACTL6B, genetic engineering, intellectual disability, neurodevelopment, seizure, stem cells, Actins, Adult, Child, Child, Preschool, Chromatin, Chromosomal Proteins, Non-Histone, DNA-Binding Proteins, Dendrites, Epilepsy, Female, Humans, Induced Pluripotent Stem Cells, Infant, Male, Mutation, Neurodevelopmental Disorders, Neurons, Young Adult
Abstract

We identified individuals with variations in ACTL6B, a component of the chromatin remodeling machinery including the BAF complex. Ten individuals harbored bi-allelic mutations and presented with global developmental delay, epileptic encephalopathy, and spasticity, and ten individuals with de novo heterozygous mutations displayed intellectual disability, ambulation deficits, severe language impairment, hypotonia, Rett-like stereotypies, and minor facial dysmorphisms (wide mouth, diastema, bulbous nose). Nine of these ten unrelated individuals had the identical de novo c.1027G>A (p.Gly343Arg) mutation. Human-derived neurons were generated that recaptured ACTL6B expression patterns in development from progenitor cell to post-mitotic neuron, validating the use of this model. Engineered knock-out of ACTL6B in wild-type human neurons resulted in profound deficits in dendrite development, a result recapitulated in two individuals with different bi-allelic mutations, and reversed on clonal genetic repair or exogenous expression of ACTL6B. Whole-transcriptome analyses and whole-genomic profiling of the BAF complex in wild-type and bi-allelic mutant ACTL6B neural progenitor cells and neurons revealed increased genomic binding of the BAF complex in ACTL6B mutants, with corresponding transcriptional changes in several genes including TPPP and FSCN1, suggesting that altered regulation of some cytoskeletal genes contribute to altered dendrite development. Assessment of bi-alleic and heterozygous ACTL6B mutations on an ACTL6B knock-out human background demonstrated that bi-allelic mutations mimic engineered deletion deficits while heterozygous mutations do not, suggesting that the former are loss of function and the latter are gain of function. These results reveal a role for ACTL6B in neurodevelopment and implicate another component of chromatin remodeling machinery in brain disease.

Published
2019

9. PET-guided omission of radiotherapy in early-stage unfavourable Hodgkin lymphoma (GHSG HD17): a multicentre, open-label, randomised, phase 3 trial

Author

Borchmann, Peter, Plütschow, Annette, Kobe, Carsten, Greil, Richard, Meissner, Julia, Topp, Max S, Ostermann, Helmut, Dierlamm, Judith, Mohm, Johannes, Thiemer, Julia, Sökler, Martin, Kerkhoff, Andrea, Ahlborn, Miriam, Halbsguth, Teresa V, Martin, Sonja, Keller, Ulrich, Balabanov, Stefan, Pabst, Thomas, Vogelhuber, Martin, Hüttmann, Andreas, Wilhelm, Martin, Zijlstra, Josée M, Moccia, Alden, Kuhnert, Georg, Bröckelmann, Paul J, von Tresckow, Bastian, Fuchs, Michael, Klimm, Beate, Rosenwald, Andreas, Eich, Hans, Baues, Christian, Marnitz, Simone, Hallek, Michael, Diehl, Volker, Dietlein, Markus, and Engert, Andreas

Published
2021
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10. Alternative donors provide comparable results to matched unrelated donors in patients with acute lymphoblastic leukemia undergoing allogeneic stem cell transplantation in second complete remission: a report from the EBMT Acute Leukemia Working Party

Author

Brissot, Eolia, Labopin, Myriam, Russo, Domenico, Martin, Sonja, Schmid, Christoph, Glass, Bertram, Ram, Ron, Ozkurt, Zubeyde Nur, Passweg, Jakob, Veelken, Joan Hendrik, Bunjes, Donald, Apperley, Jane, Giebel, Sebastian, Mohty, Mohamad, and Nagler, Arnon

Published
2020
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11. Remission induction versus immediate allogeneic haematopoietic stem cell transplantation for patients with relapsed or poor responsive acute myeloid leukaemia (ASAP): a randomised, open-label, phase 3, non-inferiority trial

Author

Stelljes, Matthias, Middeke, Jan Moritz, Bug, Gesine, Wagner-Drouet, Eva-Maria, Müller, Lutz P, Schmid, Christoph, Krause, Stefan W, Bethge, Wolfgang, Jost, Edgar, Platzbecker, Uwe, Klein, Stefan A, Schubert, Jörg, Niederland, Judith, Kaufmann, Martin, Schäfer-Eckart, Kerstin, Schaich, Markus, Baldauf, Henning, Stölzel, Friedrich, Petzold, Cathleen, Röllig, Christoph, Alakel, Nael, Steffen, Björn, Hauptrock, Beate, Schliemann, Christoph, Sockel, Katja, Lang, Fabian, Kriege, Oliver, Schaffrath, Judith, Reicherts, Christian, Berdel, Wolfgang E, Serve, Hubert, Ehninger, Gerhard, Schmidt, Alexander H, Bornhäuser, Martin, Mikesch, Jan-Henrik, Schetelig, Johannes, Alakel, Nael, Albring, Jörn, Berdel, Wolfgang E., Bethge, Wolfgang, Bornhäuser, Martin, Bug, Gesine, Buhl, Christoph, Call, Simon, Crysandt, Martina, Egger-Heidrich, Katharina, Eßeling, Eva, Faul, Christoph, Franke, Georg-Nikolaus, Georgi, Julia-Annabell, Glück-Wolf, Julia, Groth, Christoph, Hauptrock, Beate, Heidenreich, Daniela, Janjetovic, Snjezana, Jost, Edgar, Kaufmann, Martin, Kindler, Thomas, Klein, Stefan A., Krause, Stefan W., Kreil, Sebastian, Kretschmann, Theresa, Kunadt, Desiree, Lang, Fabian, Lenz, Georg, Martin, Sonja, Marx, Julia, Middeke, Jan-Moritz, Mikesch, Jan-Henrik, Müller, Lutz P., Müller, Nadine, Niederland, Judith, Parmentier, Stefani, Petzold, Kathrin, Platzbecker, Uwe, Rank, Andreas, Reicherts, Christian, Röllig, Christoph, Rösler, Wolf, Schäfer-Eckart, Kerstin, Schaffrath, Judith, Schaich, Markus, Schetelig, Johannes, Schliemann, Christoph, Schmid, Christoph, Schneidawind, Dominik, Schubert, Jörg, Serve, Hubert, Sockel, Katja, Steffen, Björn, Stelljes, Matthias, Teipel, Raphael, von Bonin, Malte, Wagner-Drouet, Eva, Wass, Maxi, and Wendelin, Knut

Abstract

Whether high-dose cytarabine-based salvage chemotherapy, administered to induce complete remission in patients with poor responsive or relapsed acute myeloid leukaemia scheduled for allogeneic haematopoietic stem-cell transplantation (HSCT) after intensive conditioning confers a survival advantage, is unclear.

Published
2024
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12. Management of Patients Undergoing CAR-T Cell Therapy in Germany.

Author

Penack, Olaf, Dreger, Peter, Ajib, Salem, Ayuk, Francis, Baermann, Ben-Niklas, Bug, Gesine, Kriege, Oliver, Jentzsch, Madlen, Kobbe, Guido, Koenecke, Christian, Lutz, Mathias, Martin, Sonja, Schlegel, Paul-Gerhard, Schroers, Roland, von Tresckow, Bastian, Vucinic, Vladan, Subklewe, Marion, Bethge, Wolfgang, and Wolff, Daniel

Subjects
STEM cell transplantation, CELLULAR therapy, HEMATOPOIETIC stem cell transplantation, CELL transplantation, CYTOKINE release syndrome, NON-Hodgkin's lymphoma
Abstract

Introduction: Chimeric antigen receptor positive T cell (CAR-T cell) treatment became standard therapy for relapsed or refractory hematologic malignancies, such as non-Hodgkin's lymphoma and multiple myeloma. Owing to the rapidly progressing field of CAR-T cell therapy and the lack of generally accepted treatment guidelines, we hypothesized significant differences between centers in the prevention, diagnosis, and management of short- and long-term complications. Methods: To capture the current CAR-T cell management among German centers to determine the medical need and specific areas for future clinical research, the DAG-HSZT (Deutsche Arbeitsgemeinschaft für Hämatopoetische Stammzelltransplantation und Zelluläre Therapie; German Working Group for Hematopoietic Stem Cell Transplantation and Cellular Therapy) performed a survey among 26 German CAR-T cell centers. Results: We received answers from 17 centers (65%). The survey documents the relevance of evidence in the CAR-T cell field with a homogeneity of practice in areas with existing clinical evidence. In contrast, in areas with no – or low quality – clinical evidence, we identified significant variety in management in between the centers: management of cytokine release syndrome, immune effector cell-related neurotoxicity syndrome, IgG substitution, autologous stem cell backups, anti-infective prophylaxis, and vaccinations. Conclusion: The results indicate the urgent need for better harmonization of supportive care in CAR-T cell therapies including clinical research to improve clinical outcome. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Inotuzumab Ozogamicin as Induction Therapy for Patients Older Than 55 Years With Philadelphia Chromosome–Negative B-Precursor ALL.

Author

Stelljes, Matthias, Raffel, Simon, Alakel, Nael, Wäsch, Ralph, Kondakci, Mustafa, Scholl, Sebastian, Rank, Andreas, Hänel, Mathias, Spriewald, Bernd, Hanoun, Maher, Martin, Sonja, Schwab, Katjana, Serve, Hubert, Reiser, Lena, Knaden, Julian, Pfeifer, Heike, Marx, Julia, Sauer, Tim, Berdel, Wolfgang E., and Lenz, Georg

Published
2024
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14. Inotuzumab Ozogamicin Induction Followed By Standard Chemotherapy Yields High Remission Rates and Promising Survival in Older (>55 Years) Patients with De Novo B-Lymphoblastic Leukemia (GMALL-Initial1 Trial)

Author

Stelljes, Matthias, Alakel, Nael, Wäsch, Ralph, Scholl, Sebastian, Nachtkamp, Kathrin, Rank, Andreas, Haenel, Mathias, Spriewald, Bernd, Hanoun, Maher, Martin, Sonja, Schwab, Katjana, Knaden, Julian, Reiser, Lena, Marx, Julia, Wethmar, Klaus, Sauer, Tim, Berdel, Wolfgang E., Lenz, Georg, Brüggemann, Monika, Raffel, Simon, and Goekbuget, Nicola

Subjects
Immunology, ddc:610, Cell Biology, Hematology, Biochemistry
Published
2022

15. Supplementary Table from Longitudinal Outcome over Two Decades of Unrelated Allogeneic Stem Cell Transplantation for Relapsed/Refractory Acute Myeloid Leukemia: An ALWP/EBMT Analysis

Author

Nagler, Arnon, primary, Ngoya, Maud, primary, Galimard, Jacques-Emmanuel, primary, Labopin, Myriam, primary, Bornhäuser, Martin, primary, Stelljes, Matthias, primary, Finke, Jürgen, primary, Ganser, Arnold, primary, Einsele, Herman, primary, Kröger, Nicolaus, primary, Brecht, Arne, primary, Bethge, Wolfgang, primary, Edinger, Matthias, primary, Kulagin, Aleksandr, primary, Passweg, Jakob, primary, Blau, Igor Wolfgang, primary, Elmaagacli, Ahmet, primary, Schäfer-Eckart, Kerstin, primary, Platzbecker, Uwe, primary, Schroeder, Thomas, primary, Bunjes, Donald, primary, Tischer, Johanna, primary, Martin, Sonja, primary, Spyridonidis, Alexandros, primary, Giebel, Sebastian, primary, Savani, Bipin, primary, and Mohty, Mohamad, primary

Published
2023
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16. Data from Longitudinal Outcome over Two Decades of Unrelated Allogeneic Stem Cell Transplantation for Relapsed/Refractory Acute Myeloid Leukemia: An ALWP/EBMT Analysis

Author

Nagler, Arnon, primary, Ngoya, Maud, primary, Galimard, Jacques-Emmanuel, primary, Labopin, Myriam, primary, Bornhäuser, Martin, primary, Stelljes, Matthias, primary, Finke, Jürgen, primary, Ganser, Arnold, primary, Einsele, Herman, primary, Kröger, Nicolaus, primary, Brecht, Arne, primary, Bethge, Wolfgang, primary, Edinger, Matthias, primary, Kulagin, Aleksandr, primary, Passweg, Jakob, primary, Blau, Igor Wolfgang, primary, Elmaagacli, Ahmet, primary, Schäfer-Eckart, Kerstin, primary, Platzbecker, Uwe, primary, Schroeder, Thomas, primary, Bunjes, Donald, primary, Tischer, Johanna, primary, Martin, Sonja, primary, Spyridonidis, Alexandros, primary, Giebel, Sebastian, primary, Savani, Bipin, primary, and Mohty, Mohamad, primary

Published
2023
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17. Supplementary Data from Longitudinal Outcome over Two Decades of Unrelated Allogeneic Stem Cell Transplantation for Relapsed/Refractory Acute Myeloid Leukemia: An ALWP/EBMT Analysis

Author

Nagler, Arnon, primary, Ngoya, Maud, primary, Galimard, Jacques-Emmanuel, primary, Labopin, Myriam, primary, Bornhäuser, Martin, primary, Stelljes, Matthias, primary, Finke, Jürgen, primary, Ganser, Arnold, primary, Einsele, Herman, primary, Kröger, Nicolaus, primary, Brecht, Arne, primary, Bethge, Wolfgang, primary, Edinger, Matthias, primary, Kulagin, Aleksandr, primary, Passweg, Jakob, primary, Blau, Igor Wolfgang, primary, Elmaagacli, Ahmet, primary, Schäfer-Eckart, Kerstin, primary, Platzbecker, Uwe, primary, Schroeder, Thomas, primary, Bunjes, Donald, primary, Tischer, Johanna, primary, Martin, Sonja, primary, Spyridonidis, Alexandros, primary, Giebel, Sebastian, primary, Savani, Bipin, primary, and Mohty, Mohamad, primary

Published
2023
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18. Outcome of 841 Older Patients (>55 yrs) with Newly Diagnosed Ph/BCR-ABL Negative ALL Prospectively Treated According to Pediatric-Based, Age-Adapted GMALL Protocols

Author

Goekbuget, Nicola, primary, Viardot, Andreas, additional, Steffen, Björn, additional, Hahn, Joachim, additional, Spriewald, Bernd, additional, Martin, Sonja, additional, Raffel, Simon, additional, Teichmann, Lino L., additional, Trummer, Arne, additional, Alsdorf, Winfried, additional, Morgner, Anke, additional, Schwartz, Stefan, additional, Stelljes, Matthias, additional, Vucinic, Vladan, additional, Alakel, Nael, additional, Stoltefuß, Andrea, additional, Baldus, Claudia D., additional, Brüggemann, Monika, additional, Serve, Hubert, additional, and Hoelzer, Dieter, additional

Published
2022
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19. Treatment Related Morbidity in Patients with Classical Hodgkin Lymphoma: Results of the Ongoing, Randomized Phase III HD21 Trial By the German Hodgkin Study Group

Author

Borchmann, Peter, primary, Moccia, Alden, additional, Greil, Richard, additional, Hertzberg, Mark, additional, Schaub, Valdete, additional, Hüttmann, Andreas, additional, Keil, Felix, additional, Dierlamm, Judith, additional, Haenel, Mathias, additional, Novak, Urban, additional, Meissner, Julia, additional, Zimmermann, Andreas, additional, Mathas, Stephan, additional, Zijlstra, Josée M., additional, Fosså, Alexander, additional, Viardot, Andreas, additional, Hertenstein, Bernd, additional, Martin, Sonja, additional, Giri, Pratyush, additional, Kamper, Peter, additional, Molin, Daniel, additional, Kreissl, Stefanie, additional, Fuchs, Michael, additional, Schneider, Gundolf, additional, Rosenwald, Andreas, additional, Klapper, Wolfram, additional, Eich, Hans, additional, Baues, Christian, additional, Hallek, Michael, additional, Dietlein, Markus, additional, Kobe, Carsten, additional, Diehl, Volker, additional, and Engert, Andreas, additional

Published
2022
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20. Inotuzumab Ozogamicin Induction Followed By Standard Chemotherapy Yields High Remission Rates and Promising Survival in Older (>55 Years) Patients with De Novo B-Lymphoblastic Leukemia (GMALL-Initial1 Trial)

Author

Stelljes, Matthias, primary, Alakel, Nael, additional, Wäsch, Ralph, additional, Scholl, Sebastian, additional, Nachtkamp, Kathrin, additional, Rank, Andreas, additional, Haenel, Mathias, additional, Spriewald, Bernd, additional, Hanoun, Maher, additional, Martin, Sonja, additional, Schwab, Katjana, additional, Knaden, Julian, additional, Reiser, Lena, additional, Marx, Julia, additional, Wethmar, Klaus, additional, Sauer, Tim, additional, Berdel, Wolfgang E., additional, Lenz, Georg, additional, Brüggemann, Monika, additional, Raffel, Simon, additional, and Goekbuget, Nicola, additional

Published
2022
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21. Integrating biological HLA-DPB1 mismatch models to predict survival after unrelated hematopoietic cell transplantation

Author

Ruggeri, Annalisa, de Wreede, Liesbeth C., Müller, Carlheinz R., Crivello, Pietro, Bonneville, Edouard F., Petersdorf, Effie W., Socié, Gerard, Dubois, Valérie, Niittyvuopio, Riitta, Peräsaari, Juha, Yakoub-Agha, Ibrahim, Cornelissen, Jan J., Wieten, Lotte, Gedde-Dahl, Tobias, Forcade, Edouard, Crawley, Charles R., Marsh, Steven G.E., Gandemer, Virginie, Tholouli, Eleni, Bulabois, Claude-Eric, Huynh, Anne, Choi, Goda, Deconinck, Eric, Itäla-Remes, Maija, Lenhoff, Stig, Bengtsson, Mats, Johansson, Jan-Erik, van Gorkom, Gwendolyn, Hoogenboom, Jorinde D., Vago, Luca, Rocha, Vanderson, Bonini, Chiara, Chabannon, Christian, Fleischhauer, Katharina, Clausen, Johannes, Holter, Wolfgang, Kalhs, Peter, Beguin, Yves, Bron, Dominique, Deeren, Dries, Lung, Wu Ka, Kerre, Tessa, Poiré, Xavier, Selleslag, Dominik, Schroyens, Wilfried, Jindra, Pavel, Mayer, Jiri, Vydra, Jan, Zák, Pavel, Nielsen, Bendt, Sengeloev, Henrik, Kaare, Ain, Partanen, Anu, Bay, Jacques-Olivier, Bertrand, Yves, Blaise, Didier, Bourhis, Jean Henri, Chevallier, Patrice, Cluzeau, Thomas, Damaj, Gandhi, Fegueux, Nathalie, Guyotat, Denis, Hunault-Berger, Mathilde, Labussière-Wallet, Hélène, Leleu, Xavier, Lioure, Bruno, Maury, Sebastien, Michel, Gérard, Mohty, Mohamad, Rubio, Marie Thérèse, Tilly, Herve, Turlure, Pascal, Bethge, Wolfgang, Casper, Jochen, Einsele, Hermann, Ganser, Arnold, Kröger, Nicolaus, Martin, Sonja, Platzbecker, Uwe, Reinhardt, Christian, Schäfer-Eckart, Kerstin, Thurner, Lorenz, Valerius, Thomas, Wulf, Gerald G., Karakasis, Dimitrios, Spyridonidis, Alexandros, Hauser, Peter, Reményi, Péter, Reykdal, Sigrun, Mousavi, Ashrafsadat, Angelucci, Emanuele, Arcese, William, Benedetti, Fabio, Bernasconi, Paolo, Biondi, Andrea, Bonifazi, Francesca, Carella, Angelo Michele, Carluccio, Paola, Casini, Marco, Cavanna, Luigi, Ciceri, Fabio, Cimino, Giuseppe, Corradini, Paolo, Fanin, Renato, Galieni, Piero, Grillo, Giovanni, Iori, Anna Paola, La Nasa, Giorgio, Locatelli, Franco, Marotta, Giuseppe, Martino, Massimo, Mazza, Patrizio, Mordini, Nicola, Musso, Maurizio, Olivieri, Attilio, Pavone, Vincenzo, Pane, Fabrizio, Petrini, Mario, Pioltelli, Pietro, Rambaldi, Alessandro, Ruggeri, Marco, Saccardi, Riccardo, Santarone, Stella, Scimè, Rosanna, Sica, Simona, Tarella, Corrado, Velardi, Andrea, Visani, Giuseppe, Zecca, Marco, Tanase, Alina, Kulagin, Aleksandr, Savchenko, Valery, López, Carmen Albo, Amor, Adrián Alegre, López, Jose Luis Bello, Caballero, Dolores, Duarte, Rafael, Cascon, Maria Jesús Pascual, Porras, Rocio Parody, Pérez-Simón, Jose Antonio, Rovira, Montserrat, Sanz, Jaime, Carrete, Juan Pio Torres, Cammenga, Jörg, Isaksson, Cecilia, Mielke, Stephan, Chalandon, Yves, Passweg, Jakob, Schanz, Urs, Meijer, Ellen, Kuball, Jürgen, Veelken, Joan Hendrik, Apperley, Jane, Bloor, Adrian, Byrne, Jenny, Carpenter, Ben, Clark, Andrew, Collin, Matthew, Craddock, Charles, Gibson, Brenda E., Khan, Anjum, Martin, Murray, Medd, Patrick, Nicholson, Emma, Orchard, Kim, Patel, Amit, Peniket, Andy, Potter, Victoria, Snowden, John, Wilson, Keith M.O., RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Transplant. Immunology/Tissue Typing lab, Interne Geneeskunde, MUMC+: MA Hematologie (9), Hematology, IRCCS San Raffaele Scientific Institute [Milan, Italie], EFS, CHU Lille, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Maastricht University Medical Centre (MUMC), Maastricht University [Maastricht], Oslo University Hospital [Oslo], CHU Bordeaux [Bordeaux], CHU Pontchaillou [Rennes], Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), University of Groningen [Groningen], Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), and Essen University Hospital

Subjects
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, [SDV]Life Sciences [q-bio], HSCT, Medizin, Hematology, Hematologi
Abstract

International audience; Not available.

Published
2023

22. T002: Treatment related morbidity in patients with classical Hodgkin Lymphoma: results of the ongoing, randomized phase III HD21 Trial by The German Hodgkin Study Group

Author

Borchmann, Peter, primary, Moccia, Alden, additional, Greil, Richard, additional, Herzberg, Mark, additional, Fosså, Alexander, additional, Hüttmann, Andreas, additional, Keil, Felix, additional, Dierlamm, Judith, additional, Schaub, Valdete, additional, Hänel, Mathias, additional, Novak, Urban, additional, Meissner, Julia, additional, Hellmuth, Johannes, additional, Mathas, Stephan, additional, Zijlstra, Josée. M., additional, Viardot, Andreas, additional, Hertenstein, Bernd, additional, Martin, Sonja, additional, Giri, Pratush, additional, Kreissl, Stefanie, additional, Fuchs, Michael, additional, Schneider, Gundolf, additional, Rosenwald, Andreas, additional, Klapper, Wolfram, additional, Eich, Hans Theodor, additional, Baues, Christian, additional, Hallek, Michael, additional, Kobe, Carsten, additional, Diehl, Volker, additional, and Engert, Andreas, additional

Published
2022
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23. Outcome of 841 Older Patients (>55 yrs) with Newly Diagnosed Ph/BCR-ABL Negative ALL Prospectively Treated According to Pediatric-Based, Age-Adapted GMALL Protocols

Author

Goekbuget, Nicola, Viardot, Andreas, Steffen, Björn, Hahn, Joachim, Spriewald, Bernd, Martin, Sonja, Raffel, Simon, Teichmann, Lino L., Trummer, Arne, Alsdorf, Winfried, Morgner, Anke, Schwartz, Stefan, Stelljes, Matthias, Vucinic, Vladan, Alakel, Nael, Stoltefuß, Andrea, Baldus, Claudia D., Brüggemann, Monika, Serve, Hubert, and Hoelzer, Dieter

Published
2022
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24. Total body irradiation + fludarabine compared to busulfan + fludarabine as 'reduced-toxicity conditioning' for patients with acute myeloid leukemia treated with allogeneic hematopoietic cell transplantation in first complete remission: a study by the Acute Leukemia Working Party of the EBMT

Author

Giebel, Sebastian, Labopin, Myriam, Sobczyk-Kruszelnicka, Malgorzata, Stelljes, Matthias, Byrne, Jenny, Fegueux, Nathalie, Beelen, Dietrich, Rovira, Montserrat, Spyridonidis, Alexandros, Blaise, Didier, Bornhäuser, Martin, Karadogan, Ihsan, Savani, Bipin, Nagler, Arnon, Mohty, Mohamad, Martin, Sonja, Chevallier, Patrice, Neubauer, Andreas, Damaj, Gandhi, Koc, Yener, Ganser, Arnold, Collin, Matthew, Yakoub-Agha, Ibrahim, Ozdogu, Hakan, Araujo, Mercedes Colorado, Itäla-Remes, Maija, Orchard, Kim, Isaksson, Cecilia, Bethge, Wolfgang, Martin, Hans, Aljurf, Mahmoud, Faber, Edgar, Caballero, Dolores, Zák, Pavel, Leleu, Xavier, Bay, Jacques-Olivier, Rohrlich, Pierre-Simon, Kröger, Nicolaus, Huynh, Anne, Schäfer-Eckart, Kerstin, Milpied, Noel, Lenhoff, Stig, Ho, Aloysius, López, Jose Luis Bello, Mordini, Nicola, Lioure, Bruno, Halaburda, Kazimierz, Olivieri, Attilio, Gedde-Dahl, Tobias, Protheroe, Rachel, Tischer, Johanna, Klammer, Matthias, Clausen, Johannes, Potter, Victoria, Ladetto, Marco, Tilly, Herve, Deconinck, Eric, Brecht, Arne, Müller, Lutz Peter, Heinicke, Thomas, Carrete, Juan Pio Torres, Bazarbachi, Ali, Reményi, Péter, Rubio, Marie Thérèse, Fanin, Renato, Pérez-Simón, Jose Antonio, Niels, Murawski, Diez-Martin, J., Arat, Mutlu, Hermine, Olivier, Socié, Gerard, Cornelissen, Jan, Santarone, Stella, Guyotat, Denis, Bulabois, Claude Eric, Bernasconi, Paolo, Johansson, Jan-Erik, Vrhovac, Radovan, Greinix, Hildegard, Lorenzo, José Luis López, Apte, Shashikant, Craddock, Charles, Kobbe, Guido, Zahrani, Mohsen Al, Dreger, Peter, Lange, Andrzej, Tbakhi, Abdelghani, Meijer, Ellen, Llamas, Carlos Vallejo, Santasusana, Josep Maria Ribera, Corradini, Paolo, Benedetti, Fabio, Rambaldi, Alessandro, Gandemer, Virginie, Malfuson, Jean-Valère, Kaare, Ain, Risitano, Antonio, Petrini, Mario, Selleri, Carmine, Wu, Depei, Hematology, CCA - Cancer Treatment and quality of life, Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, and Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
medicine.medical_specialty, Transplantation Conditioning, MESH: Busulfan, Medizin, MESH: Graft vs Host Disease, Graft vs Host Disease, [SDV.CAN]Life Sciences [q-bio]/Cancer, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Busulfan, MESH: Hematopoietic Stem Cell Transplantation, MESH: Transplantation Conditioning, Retrospective Studies, Transplantation, Acute leukemia, MESH: Humans, MESH: Middle Aged, business.industry, Hazard ratio, Hematopoietic Stem Cell Transplantation, Myeloid leukemia, MESH: Retrospective Studies, Retrospective cohort study, Hematology, Middle Aged, Total body irradiation, Fludarabine, Leukemia, Myeloid, Acute, Regimen, 030220 oncology & carcinogenesis, MESH: Vidarabine, [SDV.IMM]Life Sciences [q-bio]/Immunology, MESH: Leukemia, Myeloid, Acute, business, MESH: Whole-Body Irradiation, Vidarabine, Whole-Body Irradiation, 030215 immunology, medicine.drug
Abstract

International audience; The optimal conditioning for patients with acute myeloid leukemia in first complete remission treated with allogeneic hematopoietic cell transplantation (allo-HCT) has not been defined so far. In this retrospective study, we compared two "reduced-toxicity" regimens: intravenous busulfan at a total dose of 9.6 mg/kg (3 days) + fludarabine (Bu3/Flu) and total body irradiation at a dose of 8 Gy + fludarabine (TBI8Gy/Flu). In the entire study cohort (n = 518), the probabilities of overall survival (OS), leukemia-free survival (LFS), relapse and non-relapse mortality (NRM) at 2 years for Bu3/Flu and TBI8Gy/Flu were 62% vs. 72.5% (p = 0.051), 59.5% vs. 65% (p = 0.15), 30% vs. 20% (p = 0.01), and 10% vs. 14% (p = 0.18), respectively. In multivariate model for patients

Published
2021

25. AFM13 in patients with relapsed or refractory classical Hodgkin lymphoma: final results of an open-label, randomized, multicenter phase II trial

Author

Sasse, Stephanie, primary, Bröckelmann, Paul Jan, additional, Momotow, Jesko, additional, Plütschow, Annette, additional, Hüttmann, Andreas, additional, Basara, Nadezda, additional, Koenecke, Christian, additional, Martin, Sonja, additional, Bentz, Martin, additional, Grosse-Thie, Christina, additional, Thorspecken, Sven, additional, de Wit, Maike, additional, Kobe, Carsten, additional, Dietlein, Markus, additional, Tresckow, Bastian von, additional, Fuchs, Michael, additional, Borchmann, Peter, additional, and Engert, Andreas, additional

Published
2022
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26. Quizartinib and High-dose Ara-C plus Mitoxantrone in Relapsed/Refractory AML with FLT3-ITD

Author

Jaramillo, Sonia, primary, Cornet, Lucian Le, additional, Kratzmann, Markus, additional, Krisam, Johannes, additional, Görner, Martin, additional, Hänel, Mathias, additional, Röllig, Christoph, additional, Wass, Maxi, additional, Scholl, Sebastian, additional, Ringhoffer, Mark, additional, Reichart, Alexander, additional, Steffen, Björn, additional, Kayser, Sabine, additional, Mikesch, Jan-Henrik, additional, Schaefer-Eckart, Kerstin, additional, Schubert, Jörg, additional, Geer, Thomas, additional, Martin, Sonja, additional, Kieser, Meinhard, additional, Sauer, Tim, additional, Kriegsmann, Katharina, additional, Hundemer, Michael, additional, Serve, Hubert, additional, Bornhäuser, Martin, additional, Müller-Tidow, Carsten, additional, and Schlenk, Richard F., additional

Published
2022
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27. Longitudinal Outcome over Two Decades of Unrelated Allogeneic Stem Cell Transplantation for Relapsed/Refractory Acute Myeloid Leukemia: An ALWP/EBMT Analysis

Author

Nagler, Arnon, primary, Ngoya, Maud, additional, Galimard, Jacques-Emmanuel, additional, Labopin, Myriam, additional, Bornhäuser, Martin, additional, Stelljes, Matthias, additional, Finke, Jürgen, additional, Ganser, Arnold, additional, Einsele, Herman, additional, Kröger, Nicolaus, additional, Brecht, Arne, additional, Bethge, Wolfgang, additional, Edinger, Matthias, additional, Kulagin, Aleksandr, additional, Passweg, Jakob, additional, Blau, Igor Wolfgang, additional, Elmaagacli, Ahmet, additional, Schäfer-Eckart, Kerstin, additional, Platzbecker, Uwe, additional, Schroeder, Thomas, additional, Bunjes, Donald, additional, Tischer, Johanna, additional, Martin, Sonja, additional, Spyridonidis, Alexandros, additional, Giebel, Sebastian, additional, Savani, Bipin, additional, and Mohty, Mohamad, additional

Published
2022
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28. Treatment Related Morbidity in Patients with Classical Hodgkin Lymphoma: Results of the Ongoing, Randomized Phase III HD21 Trial By the German Hodgkin Study Group

Author

Borchmann, Peter, Moccia, Alden, Greil, Richard, Hertzberg, Mark, Schaub, Valdete, Huettmann, Andreas, Keil, Felix, Dierlamm, Judith, Haenel, Mathias, Novak, Urban, Meissner, Julia, Zimmermann, Andreas, Mathas, Stephan, Zijlstra, Josee M., Fossa, Alexander, Viardot, Andreas, Hertenstein, Bernd, Martin, Sonja, Giri, Pratyush, Kamper, Peter, Molin, Daniel, Kreissl, Stefanie, Fuchs, Michael, Schneider, Gundolf, Rosenwald, Andreas, Klapper, Wolfram, Eich, Hans, Baues, Christian, Hallek, Michael, Dietlein, Markus, Kobe, Carsten, Diehl, Volker, Engert, Andreas, Borchmann, Peter, Moccia, Alden, Greil, Richard, Hertzberg, Mark, Schaub, Valdete, Huettmann, Andreas, Keil, Felix, Dierlamm, Judith, Haenel, Mathias, Novak, Urban, Meissner, Julia, Zimmermann, Andreas, Mathas, Stephan, Zijlstra, Josee M., Fossa, Alexander, Viardot, Andreas, Hertenstein, Bernd, Martin, Sonja, Giri, Pratyush, Kamper, Peter, Molin, Daniel, Kreissl, Stefanie, Fuchs, Michael, Schneider, Gundolf, Rosenwald, Andreas, Klapper, Wolfram, Eich, Hans, Baues, Christian, Hallek, Michael, Dietlein, Markus, Kobe, Carsten, Diehl, Volker, and Engert, Andreas

Published
2022

29. AFM13 in patients with relapsed or refractory classical Hodgkin lymphoma: final results of an open-label, randomized, multicenter phase II trial

Author

Sasse, Stephanie, Brockelmann, Paul Jan, Momotow, Jesko, Plutschow, Annette, Huttmann, Andreas, Basara, Nadezda, Koenecke, Christian, Martin, Sonja, Bentz, Martin, Grosse-Thie, Christina, Thorspecken, Sven, de Wit, Maike, Kobe, Carsten, Dietlein, Markus, v Tresckow, Bastian, Fuchs, Michael, Borchmann, Peter, Engert, Andreas, Sasse, Stephanie, Brockelmann, Paul Jan, Momotow, Jesko, Plutschow, Annette, Huttmann, Andreas, Basara, Nadezda, Koenecke, Christian, Martin, Sonja, Bentz, Martin, Grosse-Thie, Christina, Thorspecken, Sven, de Wit, Maike, Kobe, Carsten, Dietlein, Markus, v Tresckow, Bastian, Fuchs, Michael, Borchmann, Peter, and Engert, Andreas

Abstract

In patients with relapse of classical Hodgkin lymphoma (cHL) after autologous stem cell transplant, brentuximab vedotin and anti-PD1 treatment, the outcome is poor. To assess the efficacy of the bispecific anti-CD30/CD16A, NK-cell engaging antibody AFM13 and to select the optimal treatment schedule (arm A-C), we initiated a randomized two-stage phase II trial (NCT02321592). Due to slow recruitment, the trial was terminated after treatment of 25 patients. Treatment with AFM13 was well tolerated: only two treatment-associated serious adverse events (SAEs) were reported; all SAEs resolved completely. With an objective response rate (ORR) of 16.7% (1/5 in arm A, 1/11 in arm B, and 2/8 in arm C) and a 12-month progression-free survival (PFS) of 12.6% (95% CI 3.2-28.9), treatment efficacy of AFM13 monotherapy in all evaluable patients was modest. The continuous application schedule (arm C) might be more effective, but the visit schedule should be better aligned with patients' daily life.

Published
2022

30. Two cycles of risk-adapted consolidation therapy in patients with acute promyelocytic leukemia. Results from the SAL-AIDA2000 trial

Author

Röllig, Christoph, Schäfer-Eckardt, Kerstin, Hänel, Matthias, Kramer, Michael, Schaich, Markus, Thiede, Christian, Oelschlägel, Uta, Mohr, Brigitte, Wagner, Thomas, Einsele, Hermann, Krause, Stefan W., Bodenstein, Heinrich, Martin, Sonja, Stuhlmann, Reingard, Ho, Antony D., Bornhäuser, Martin, Ehninger, Gerhard, Schuler, Ulrich, and Platzbecker, Uwe

Published
2015
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31. Evaluation of Trends in Outcome over 2 Decades of Patients with Relapsed/Refractory Acute Myelogenous Leukemia Undergoing Allogeneic Stem Cell Transplantation from Unrelated Donors: An ALWP/EBMT Analysis

Author

Nagler, Arnon, primary, Ngoya, Maud, additional, Labopin, Myriam, additional, Bornhauser, Martin, additional, Stelljes, Matthias, additional, Finke, Jürgen, additional, Ganser, Arnold, additional, Einsele, Hermann, additional, Kroger, Nicolaus, additional, Brecht, Arne, additional, Bethge, Wolfgang, additional, Edinger, Matthias, additional, Kulagin, Aleksandr, additional, Passweg, Jakob, additional, Elmaagacli, Ahmet, additional, Schafer-Eckart, K., additional, Platzbecker, Uwe, additional, Schroeder, Thomas, additional, Bunjes, Donald, additional, Tischer, Johanna, additional, Martin, Sonja, additional, Spyridonidis, Alexandros, additional, Giebel, Sebastian, additional, Savani, Bipin, additional, and Mohty, Mohamad, additional

Published
2022
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32. Addition of AEG35156 XIAP Antisense Oligonucleotide in Reinduction Chemotherapy Does Not Improve Remission Rates in Patients With Primary Refractory Acute Myeloid Leukemia in a Randomized Phase II Study

Author

Schimmer, Aaron D., Herr, Wolfgang, Hänel, Mathias, Borthakur, Gautham, Frankel, Arthur, Horst, Heinz-August, Martin, Sonja, Kassis, Jeannine, Desjardins, Pierre, Seiter, Karen, Fiedler, Walter, Noppeney, Richard, Giagounidis, Aristoteles, Jacob, Christine, Jolivet, Jacques, Tallman, Martin S., and Koschmieder, Steffen

Published
2011
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33. First Results of the Risk-Adapted, MRD-Stratified GMALL Trial 08/2013 in 705 Adults with Newly Diagnosed Acute Lymphoblastic Leukemia/Lymphoma (ALL/LBL)

Author

Goekbuget, Nicola, primary, Stelljes, Matthias, additional, Viardot, Andreas, additional, Nachtkamp, Kathrin, additional, Steffen, Björn, additional, Schneller, Folker, additional, Alakel, Nael, additional, Topp, Max, additional, Böll, Boris, additional, Faul, Christoph, additional, Spiekermann, Karsten, additional, Wendelin, Knut, additional, Hanoun, Maher, additional, Wäsch, Ralph, additional, Beck, Joachim, additional, Martin, Sonja, additional, Vucinic, Vladan, additional, Baldus, Claudia D., additional, Brüggemann, Monika, additional, Burmeister, Thomas, additional, Pfeifer, Heike, additional, Schwartz, Stefan, additional, Baumann, Lena, additional, Tichy, Diana, additional, Serve, Hubert, additional, and Fiedler, Walter, additional

Published
2021
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34. Final Induction Therapy Results of an Open Label Phase II Study Using Inotuzumab Ozogamicin for Induction Therapy, Followed By a Conventional Chemotherapy Based Consolidation and Maintenance Therapy in Patients Aged 56 Years and Older with Acute B-Lymphoblastic Leukemia (INITIAL-1 trial)

Author

Stelljes, Matthias, primary, Alakel, Nael, additional, Wäsch, Ralph, additional, Scholl, Sebastian, additional, Nachtkamp, Kathrin, additional, Rank, Andreas, additional, Haenel, Mathias, additional, Spriewald, Bernd, additional, Hanoun, Maher, additional, Martin, Sonja, additional, Schwab, Katjana, additional, Knaden, Julian, additional, Marx, Julia, additional, Wethmar, Klaus, additional, Sauer, Tim, additional, Berdel, Wolfgang E., additional, Lenz, Georg, additional, Dugas, Martin, additional, Goekbuget, Nicola, additional, Brueggemann, Monika, additional, and Raffel, Simon, additional

Published
2021
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35. First Results of an Open Label Phase II Study to Evaluate the Efficacy and Safety of Inotuzumab Ozogamicin for Induction Therapy Followed By a Conventional Chemotherapy Based Consolidation and Maintenance Therapy in Patients Aged 56 Years and Older with Acute Lymphoblastic Leukemia (INITIAL-1 trial)

Author

Stelljes, Matthias, primary, Raffel, Simon, additional, Wäsch, Ralph, additional, Scholl, Sebastian, additional, Kondakci, Mustafa, additional, Rank, Andreas, additional, Haenel, Mathias, additional, Martin, Sonja, additional, Schwab, Katjana, additional, Knaden, Julian, additional, Wethmar, Klaus, additional, Sauer, Tim, additional, Berdel, Wolfgang E., additional, Lenz, Georg, additional, Dugas, Martin, additional, Brüggemann, Monika, additional, Goekbuget, Nicola, additional, and Alakel, Nael, additional

Published
2020
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36. AFM13 in Patients with Relapsed or Refractory Hodgkin Lymphoma: Final Results of an Open-Label, Randomized, Multicenter Phase II Trial

Author

Sasse, Stephanie, primary, Momotow, Jesko, additional, Plütschow, Annette, additional, Hüttmann, Andreas, additional, Basara, Nadezda, additional, Koenecke, Christian, additional, Martin, Sonja, additional, Bentz, Martin, additional, Grosse-Thie, Christina, additional, Thorspecken, Sven, additional, de Wit, Maike, additional, Kobe, Carsten, additional, Dietlein, Markus, additional, von Tresckow, Bastian, additional, Fuchs, Michael, additional, Borchmann, Peter, additional, and Engert, Andreas, additional

Published
2020
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37. Interim Results of a Multicenter, Single-Arm Study to Assess Blinatumomab in Adult Patients (pts) with Minimal Residual Disease (MRD) of B-Precursor (BCP) Acute Lymphoblastic Leukemia (GMALL-MOLACT1-BLINA)

Author

Goekbuget, Nicola, primary, Wermann, Wiba Keke, additional, Schwartz, Stefan, additional, Hüttmann, Andreas, additional, Faul, Christoph, additional, Raffel, Simon, additional, Viardot, Andreas, additional, Fiedler, Walter, additional, Alakel, Nael, additional, Stelljes, Matthias, additional, Subklewe, Marion, additional, Wäsch, Ralph, additional, Martin, Sonja, additional, Jung, Wolfram, additional, Vucinic, Vladan, additional, Kondakci, Mustafa, additional, Fransecky, Lars R., additional, Heidenreich, Daniela, additional, Wendelin, Knut, additional, Hermann, Julian, additional, Serve, Hubert, additional, Bargou, Ralf C, additional, Topp, Max S., additional, and Brüggemann, Monika, additional

Published
2020
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38. Outcome of allogeneic haematopoietic stem cell transplantation in myeloproliferative neoplasm, unclassifiable: a retrospective study by the Chronic Malignancies Working Party of the EBMT

Author

McLornan, Donal P., primary, Malpassuti, Vittoria, additional, Lippinkhof‐Kozijn, Anne, additional, Potter, Victoria, additional, Beelen, Dietrich, additional, Bunjes, Donald, additional, Sengeloev, Henrik, additional, Radujkovic, Aleksandar, additional, Passweg, Jakob, additional, Chalandon, Yves, additional, Kröger, Nicolaus, additional, Wulf, Gerald G., additional, Johansson, Jan‐Erik, additional, Ciceri, Fabio, additional, Bornhäuser, Martin, additional, Holler, Ernst, additional, Guffroy, Blandine, additional, Martin, Sonja, additional, Neubauer, Andreas, additional, Gramatski, Martin, additional, Robin, Marie, additional, Iacobelli, Simona, additional, Hayden, Patrick, additional, Hernández Boluda, Juan C., additional, Czerw, Tomasz, additional, and Yakoub‐Agha, Ibrahim, additional

Published
2020
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39. Outcome of Allogeneic Haematopoietic Stem Cell Transplantation in Myeloproliferative Neoplasms-Unclassifiable: A Retrospective Study By the Chronic Malignancies Working Party of EBMT

Author

McLornan, Donal P., primary, Malpassuti, Vittoria, additional, Iacobelli, Simona, additional, Lippinkhof-Kozijn, Anne, additional, Koster, Linda, additional, Robin, Marie, additional, Chalandon, Yves, additional, Bunjes, Donald, additional, Beelen, Dietrich W., additional, Potter, Victoria, additional, Sengeloev, Henrik, additional, Radujkovic, Aleksandar, additional, Passweg, Jakob R., additional, Kröger, Nicolaus, additional, Wulf, Gerald, additional, Johansson, Jan Erik, additional, Ciceri, Fabio, additional, Bornhäuser, Martin, additional, Holler, Ernst, additional, Beguin, Yves, additional, Lioure, Bruno, additional, Martin, Sonja, additional, Milojkovic, Dragana, additional, Hayden, Patrick, additional, Hernandez Boluda, Juan Carlos, additional, Czerw, Tomasz, additional, and yakoub-Agha, Ibrahim, additional

Published
2019
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40. The Impact of Optimal Demand Response Control and Thermal Energy Storage on a District Heating System

Author

Martin, Sonja Salo, Aira Hast, Juha Jokisalo, Risto Kosonen, Sanna Syri, Janne Hirvonen, and Kristian

Subjects
demand response, district heating, hot water storage, rule-based control
Abstract

Demand response has been studied in district heating connected buildings since the rollout of smart, communicating devices has made it cost-effective to control buildings’ energy consumption externally. This research investigates optimal demand response control strategies from the district heating operator perspective. Based on earlier simulations on the building level, different case algorithms were simulated on a typical district heating system. The results show that even in the best case, heat production costs can be decreased by only 0.7%. However, by implementing hot water thermal storage in the system, demand response can become more profitable, resulting in 1.4% cost savings. It is concluded that the hot water storage tank can balance district heating peak loads for longer periods of time, which enhances the ability to use demand response strategies on a larger share of the building stock.

Published
2019
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42. Immunochemotherapy With Rituximab and Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone Significantly Improves Response and Time to Treatment Failure, But Not Long-Term Outcome in Patients With Previously Untreated Mantle Cell Lymphoma: Results of a Prospective Randomized Trial of the German Low Grade Lymphoma Study Group (GLSG)

Author

Lenz, Georg, Dreyling, Martin, Hoster, Eva, Wörmann, Bernhard, Dührsen, Ulrich, Metzner, Bernd, Eimermacher, Hartmut, Neubauer, Andreas, Wandt, Hannes, Steinhauer, Hjalmar, Martin, Sonja, Heidemann, Else, Aldaoud, Ali, Parwaresch, Reza, Hasford, Joerg, Unterhalt, Michael, and Hiddemann, Wolfgang

Published
2005
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43. Mutations in ACTL6B Cause Neurodevelopmental Deficits and Epilepsy and Lead to Loss of Dendrites in Human Neurons

Author

Genetica, Genetica Klinische Genetica, Brain, Child Health, Genetica Sectie Genoomdiagnostiek, CMM Sectie Genomics and Bioinformatics, Bell, Scott, Rousseau, Justine, Peng, Huashan, Aouabed, Zahia, Priam, Pierre, Theroux, Jean Francois, Jefri, Malvin, Tanti, Arnaud, Wu, Hanrong, Kolobova, Ilaria, Silviera, Heika, Manzano-Vargas, Karla, Ehresmann, Sophie, Hamdan, Fadi F., Hettige, Nuwan, Zhang, Xin, Antonyan, Lilit, Nassif, Christina, Ghaloul-Gonzalez, Lina, Sebastian, Jessica, Vockley, Jerry, Begtrup, Amber G., Wentzensen, Ingrid M., Crunk, Amy, Nicholls, Robert D., Herman, Kristin C., Deignan, Joshua L., Al-Hertani, Walla, Efthymiou, Stephanie, Salpietro, Vincenzo, Miyake, Noriko, Makita, Yoshio, Matsumoto, Naomichi, Østern, Rune, Houge, Gunnar, Hafström, Maria, Fassi, Emily, Houlden, Henry, Klein Wassink-Ruiter, Jolien S., Nelson, Dominic, Goldstein, Amy, Dabir, Tabib, van Gils, Julien, Bourgeron, Thomas, Delorme, Richard, Cooper, Gregory M., Martinez, Jose E., Finnila, Candice R., Carmant, Lionel, Lortie, Anne, Oegema, Renske, van Gassen, Koen, Mehta, Sarju G., Huhle, Dagmar, Abou Jamra, Rami, Martin, Sonja, Brunner, Han G., Lindhout, Dick, Au, Margaret, Graham, John M., Coubes, Christine, Turecki, Gustavo, Gravel, Simon, Mechawar, Naguib, Rossignol, Elsa, Michaud, Jacques L., Lessard, Julie, Ernst, Carl, Campeau, Philippe M., Genetica, Genetica Klinische Genetica, Brain, Child Health, Genetica Sectie Genoomdiagnostiek, CMM Sectie Genomics and Bioinformatics, Bell, Scott, Rousseau, Justine, Peng, Huashan, Aouabed, Zahia, Priam, Pierre, Theroux, Jean Francois, Jefri, Malvin, Tanti, Arnaud, Wu, Hanrong, Kolobova, Ilaria, Silviera, Heika, Manzano-Vargas, Karla, Ehresmann, Sophie, Hamdan, Fadi F., Hettige, Nuwan, Zhang, Xin, Antonyan, Lilit, Nassif, Christina, Ghaloul-Gonzalez, Lina, Sebastian, Jessica, Vockley, Jerry, Begtrup, Amber G., Wentzensen, Ingrid M., Crunk, Amy, Nicholls, Robert D., Herman, Kristin C., Deignan, Joshua L., Al-Hertani, Walla, Efthymiou, Stephanie, Salpietro, Vincenzo, Miyake, Noriko, Makita, Yoshio, Matsumoto, Naomichi, Østern, Rune, Houge, Gunnar, Hafström, Maria, Fassi, Emily, Houlden, Henry, Klein Wassink-Ruiter, Jolien S., Nelson, Dominic, Goldstein, Amy, Dabir, Tabib, van Gils, Julien, Bourgeron, Thomas, Delorme, Richard, Cooper, Gregory M., Martinez, Jose E., Finnila, Candice R., Carmant, Lionel, Lortie, Anne, Oegema, Renske, van Gassen, Koen, Mehta, Sarju G., Huhle, Dagmar, Abou Jamra, Rami, Martin, Sonja, Brunner, Han G., Lindhout, Dick, Au, Margaret, Graham, John M., Coubes, Christine, Turecki, Gustavo, Gravel, Simon, Mechawar, Naguib, Rossignol, Elsa, Michaud, Jacques L., Lessard, Julie, Ernst, Carl, and Campeau, Philippe M.

Published
2019

44. 141 - Evaluation of Trends in Outcome over 2 Decades of Patients with Relapsed/Refractory Acute Myelogenous Leukemia Undergoing Allogeneic Stem Cell Transplantation from Unrelated Donors: An ALWP/EBMT Analysis

Author

Nagler, Arnon, Ngoya, Maud, Labopin, Myriam, Bornhauser, Martin, Stelljes, Matthias, Finke, Jürgen, Ganser, Arnold, Einsele, Hermann, Kroger, Nicolaus, Brecht, Arne, Bethge, Wolfgang, Edinger, Matthias, Kulagin, Aleksandr, Passweg, Jakob, Elmaagacli, Ahmet, Schafer-Eckart, K., Platzbecker, Uwe, Schroeder, Thomas, Bunjes, Donald, Tischer, Johanna, Martin, Sonja, Spyridonidis, Alexandros, Giebel, Sebastian, Savani, Bipin, and Mohty, Mohamad

Published
2022
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45. Asparaginase activities during intensified treatment with pegylatedE. coliasparaginase in adults with newly-diagnosed acute lymphoblastic leukemia

Author

Lanvers-Kaminsky, Claudia, primary, Niemann, Andreas, additional, Eveslage, Maria, additional, Beck, Joachim, additional, Köhnke, Thomas, additional, Martin, Sonja, additional, de Wit, Maike, additional, Spriewald, Bernd, additional, Hauspurg, Holger, additional, Hoelzer, Dieter, additional, Boos, Joachim, additional, and Gökbuget, Nicola, additional

Published
2019
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46. Scientific evaluation of negative exome sequencing followed by systematic scoring of candidate genes to decipher the genetics of neurodevelopmental disorders

Author

Büttner, Benjamin, primary, Martin, Sonja, additional, Finck, Anja, additional, Arelin, Maria, additional, Baade-Büttner, Carolin, additional, Bartolomaeus, Tobias, additional, Bauer, Peter, additional, Bertsche, Astrid, additional, Bernhard, Matthias K., additional, Biskup, Saskia, additional, Donato, Nataliya Di, additional, Elgizouli, Magdeldin, additional, Ewald, Roland, additional, Heine, Constanze, additional, Hellenbroich, Yorck, additional, Hentschel, Julia, additional, Hoffjan, Sabine, additional, Horn, Susanne, additional, Hornemann, Frauke, additional, Huhle, Dagmar, additional, Kamphausen, Susanne B., additional, Kiess, Wieland, additional, Krey, Ilona, additional, Kuechler, Alma, additional, Liesfeld, Ben, additional, Merkenschlager, Andreas, additional, Mitter, Diana, additional, Muschke, Petra, additional, Pfäffle, Roland, additional, Polster, Tilman, additional, Schanze, Ina, additional, Schlump, Jan-Ulrich, additional, Syrbe, Steffen, additional, Wieczorek, Dagmar, additional, Zenker, Martin, additional, Lemke, Johannes R., additional, Duc, Diana Le, additional, Platzer, Konrad, additional, and Jamra, Rami Abou, additional

Published
2019
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47. Prognostic Value of a New Clinically-Based Classification System in Patients with CMML Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: A Retrospective Analysis of the EBMT Chronic Malignancies Working Party

Author

Onida, Francesco, primary, Sbianchi, Giulia, additional, Koster, Linda, additional, Iacobelli, Simona, additional, Dreger, Peter, additional, Bornhäuser, Martin, additional, Kröger, Nicolaus, additional, Sierra, Jorge, additional, Socié, Gérard, additional, Cornelissen, Jan J, additional, Poire, Xavier, additional, Faber, Edgar, additional, Bourhis, Jean-Henri, additional, Finke, Jürgen, additional, Passweg, Jakob R., additional, Salmenniemi, Urpu, additional, Schouten, Harry C., additional, Beguin, Yves, additional, Martin, Sonja, additional, Deconinck, Eric, additional, Ganser, Arnold, additional, Zver, Samo, additional, Lioure, Bruno, additional, Russell, Nigel H., additional, Robin, Marie, additional, and Yakoub-Agha, Ibrahim, additional

Published
2018
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48. Comorbidities Are Frequent in Older Patients with De Novo Acute Lymphoblastic Leukemia (ALL) and Correlate with Induction Mortality: Analysis of More Than 1200 Patients from GMALL Data Bases

Author

Wermann, Wiba Keke, primary, Viardot, Andreas, additional, Kayser, Sabine, additional, Alakel, Nael, additional, Elmaagacli, Ahmet, additional, Faul, Christoph, additional, Fiedler, Walter, additional, Horst, Heinz A., additional, Lange, Elisabeth, additional, Martin, Sonja, additional, Mohamed, Omar, additional, Morgner, Anke, additional, Reichle, Albrecht, additional, Spiekermann, Karsten, additional, Spriewald, Bernd, additional, Starck, Michael, additional, Stelljes, Matthias, additional, Trummer, Arne, additional, Vucinic, Vladan, additional, Serve, Hubert, additional, Hoelzer, Dieter, additional, and Goekbuget, Nicola, additional

Published
2018
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49. Asparaginase activities during intensified treatment with pegylated E. coli asparaginase in adults with newly-diagnosed acute lymphoblastic leukemia.

Author

Lanvers-Kaminsky, Claudia, Niemann, Andreas, Eveslage, Maria, Beck, Joachim, Köhnke, Thomas, Martin, Sonja, de Wit, Maike, Spriewald, Bernd, Hauspurg, Holger, Hoelzer, Dieter, Boos, Joachim, and Gökbuget, Nicola

Subjects
LYMPHOBLASTIC leukemia, ASPARAGINASE, ACUTE leukemia, ADULTS, DRUG monitoring
Abstract

The GMALL07/2003 protocol introduced pegylated E. coli asparaginase (PEG-ASNase) frontline for adults with acute lymphoblastic leukemia (ALL). PEG-ASNase (500 U/m2, 1000 U/m2, or 2000 U/m2) was given once in induction and as part of three HD-MTX/PEG-ASNase cycles with two PEG-ASNase doses every other week in consolidation. PEG-ASNase activities were monitored in 1363 serum samples from 304 ALL patients. The overall rate of silent inactivation was low (5%) and did not differ between induction and consolidation. The successful targeting of PEG-ASNase activities ≥100 U/L depended on protocol and dose. Overall PEG-ASNase activities were higher during consolidation compared to induction. To target PEG-ASNase activities ≥100 U/L for 14 day with a single dose in induction, 2000 U/m2 was more preferable than 1000 U/m2 or 500 U/m2. During consolidation with two administrations every other week, 1000 U/m2 and 2000 U/m2 were similarly effective in sustaining PEG-ASNase ≥100 U/L activities over 14 days. [ABSTRACT FROM AUTHOR]

Published
2020
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50. Myeloablative Versus Reduced Intensity Conditioning Allogeneic Stem Cell Transplantation for Secondary Acute Myeloid Leukemia in Patients with Prior Myelodysplastic Syndrome/ Myeloproliferative Disorders: An ALWP of EBMT Study

Author

Savani, Bipin N., primary, Boumendil, Ariane, additional, Labopin, Myriam, additional, Finke, Jürgen, additional, Stelljes, Matthias, additional, Ganser, Arnold, additional, Wulf, Gerald, additional, Volin, Liisa, additional, Martin, Sonja, additional, Blaise, Didier, additional, Maertens, Johan, additional, Bourhis, Jean-Henri, additional, Yañez, Lucrecia, additional, Sierra, Jorge, additional, Fegueux, Nathalie, additional, Gehlkopf, Eve, additional, Schroyens, Wilfried, additional, Mailhol, Audrey, additional, Gilleece, Maria Helena, additional, Gorin, Norbert Claude, additional, Esteve, Jordi, additional, Ciceri, Fabio, additional, Baron, Frederic, additional, Schmid, Christoph, additional, Giebel, Sebastian, additional, Mohty, Mohamad, additional, and Nagler, Arnon, additional

Published
2017
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