149 results on '"Martin Lehnert"'
Search Results
2. Night work, chronotype and cortisol at awakening in female hospital employees
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Katarzyna Burek, Sylvia Rabstein, Thomas Kantermann, Céline Vetter, Markus Rotter, Rui Wang-Sattler, Martin Lehnert, Dirk Pallapies, Karl-Heinz Jöckel, Thomas Brüning, and Thomas Behrens
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Medicine ,Science - Abstract
Abstract To examine the effect of night shift on salivary cortisol at awakening (C1), 30 min later (C2), and on the cortisol awakening response (CAR, the difference between C2 and C1). We compared shift and non-shift workers with a focus on the impact of worker chronotype. Our study included 66 shift-working females (mean age = 37.3 years, SD = 10.2) and 21 non-shift working females (mean age = 47.0 years, SD = 8.9). The shift workers collected their saliva samples at C1 and C2 on each two consecutive day shifts and night shifts. Non-shift workers collected their samples on two consecutive day shifts. We applied linear mixed-effects models (LMM) to determine the effect of night shift on CAR and log-transformed C1 and C2 levels. LMMs were stratified by chronotype group. Compared to non-shift workers, shift workers before day shifts (i.e. after night sleep) showed lower cortisol at C1 (exp $$(\widehat{\beta })$$ ( β ^ ) =0.58, 95% CI 0.42, 0.81) but not at C2. In shift workers, the CARs after night shifts (i.e. after day sleep) were lower compared to CARs before day shifts ( $$\widehat{\beta }$$ β ^ = − 11.07, 95% CI − 15.64, − 6.50). This effect was most pronounced in early chronotypes (early: $$\widehat{\beta }$$ β ^ = − 16.61, 95% CI − 27.87, − 5.35; intermediate: $$\widehat{\beta }$$ β ^ = − 11.82, 95% CI − 18.35, − 5.29; late: $$\widehat{\beta }$$ β ^ = − 6.27, 95% CI − 14.28, 1.74). Chronotype did not modify the association between night shift and CAR. In our population of shift workers, there was a mismatch between time of waking up and their natural cortisol peak at waking up (CAR) both during day and night shift duties.
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- 2022
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3. Determinants of plasma calretinin in patients with malignant pleural mesothelioma
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Martin Lehnert, Daniel G. Weber, Dirk Taeger, Irina Raiko, Jens Kollmeier, Susann Stephan-Falkenau, Thomas Brüning, Georg Johnen, and the MoMar-Study Group
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Malignant pleural mesothelioma ,Molecular marker ,Plasma calretinin ,Enzyme-linked immunosorbent assay ,Tissue staining ,Medicine ,Biology (General) ,QH301-705.5 ,Science (General) ,Q1-390 - Abstract
Abstract Objective Calretinin is a well-known immunohistochemical tissue marker in the diagnosis of malignant mesothelioma. Promising results also indicate the use in early detection. In the present cross-sectional survey, correlations of calretinin plasma levels with clinical features were investigated. Plasma samples of 60 patients with malignant pleural mesothelioma (MPM) and 111 cancer-free controls formerly exposed to asbestos were compared. Calretinin concentrations were determined in plasma using an enzyme-linked immunosorbent assay (ELISA). Results The median concentration was higher in MPM patients than in controls (0.79 vs. 0.23 ng/ml; p
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- 2020
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4. Circulating long non-coding RNA GAS5 (growth arrest-specific transcript 5) as a complement marker for the detection of malignant mesothelioma using liquid biopsies
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Daniel G. Weber, Swaantje Casjens, Alexander Brik, Irina Raiko, Martin Lehnert, Dirk Taeger, Jan Gleichenhagen, Jens Kollmeier, Torsten T. Bauer, Thomas Brüning, Georg Johnen, and the MoMar study group
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Biomarker ,Blood ,Cancer ,Circulating ,Early detection ,Liquid biopsy ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Abstract Background For the detection of malignant mesothelioma additional markers are needed besides the established panel consisting of calretinin and mesothelin. The aim of this study was the identification and verification of long non-coding RNAs (lncRNAs) as complementing circulating markers. Methods Candidate lncRNAs were identified in silico using previously published RNA expression profiles and verified using quantitative PCR (qPCR) in mesothelioma cell lines as well as human plasma samples from mesothelioma patients and asbestos-exposed controls. Results GAS5 (growth arrest-specific transcript 5) as a single marker is marked by a low sensitivity of 14%, but the combination of GAS5 with calretinin and mesothelin increased the panel’s sensitivity from 64 to 73% at a predefined specificity of 97%. Circulating GAS5 is not affected by pleurectomy before blood collection, age, or smoking status. Conclusions GAS5 is verified as an appropriate circulating marker for the supplement of calretinin and mesothelin to detect malignant mesothelioma. Although the sensitivity of GAS5 is too low for the use as a single marker, the addition of GAS5 as a third marker improves the performance of the established marker panel. The benefit of GAS5 for the detection of malignant mesothelioma at early stages needs to be validated in a prospective study.
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- 2020
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5. Mesothelin Gene Variants Affect Soluble Mesothelin-Related Protein Levels in the Plasma of Asbestos-Exposed Males and Mesothelioma Patients from Germany
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Hans-Peter Rihs, Swaantje Casjens, Irina Raiko, Jens Kollmeier, Martin Lehnert, Kerstin Nöfer, Kerstin May-Taube, Nina Kaiser, Dirk Taeger, Thomas Behrens, Thomas Brüning, and Georg Johnen
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asbestos ,MoMar cohort ,prospective study ,prediagnostic mesothelioma ,manifest mesothelioma ,mesothelin ,Biology (General) ,QH301-705.5 - Abstract
Malignant mesothelioma (MM) is a severe disease mostly caused by asbestos exposure. Today, one of the best available biomarkers is the soluble mesothelin-related protein (SMRP), also known as mesothelin. Recent studies have shown that mesothelin levels are influenced by individual genetic variability. This study aimed to investigate the influence of three mesothelin (MSLN) gene variants (SNPs) in the 5′-untranslated promoter region (5′-UTR), MSLN rs2235503 C > A, rs3764246 A > G, rs3764247 A > C, and one (rs1057147 G > A) in the 3′-untranslated region (3′-UTR) of the MSLN gene on plasma concentrations of mesothelin in 410 asbestos-exposed males without cancer and 43 males with prediagnostic MM (i.e., with MM diagnosed later on) from the prospective MoMar study, as well as 59 males with manifest MM from Germany. The mesothelin concentration differed significantly between the different groups (p < 0.0001), but not between the prediagnostic and manifest MM groups (p = 0.502). Five to eight mutations of the four SNP variants studied were associated with increased mesothelin concentrations (p = 0.001). The highest mesothelin concentrations were observed for homozygous variants of the three promotor SNPs in the 5′-UTR (p < 0.001), and the highest odds ratio for an elevated mesothelin concentration was observed for MSLN rs2235503 C > A. The four studied SNPs had a clear influence on the mesothelin concentration in plasma. Hence, the analysis of these SNPs may help to elucidate the diagnostic background of patients displaying increased mesothelin levels and might help to reduce false-positive results when using mesothelin for MM screening in high-risk groups.
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- 2022
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6. Are circulating microRNAs suitable for the early detection of malignant mesothelioma? Results from a nested case–control study
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Daniel Gilbert Weber, Alexander Brik, Swaantje Casjens, Katarzyna Burek, Martin Lehnert, Beate Pesch, Dirk Taeger, Thomas Brüning, Georg Johnen, and the MoMar study group
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Biomarker ,Blood ,Cancer ,Liquid biopsies ,Mesothelioma ,MicroRNA ,Medicine ,Biology (General) ,QH301-705.5 ,Science (General) ,Q1-390 - Abstract
Abstract Objective Malignant mesothelioma is an aggressive cancer of the serous membranes. For the detection of the tumor at early stages non- or minimally-invasive biomarkers are needed. The circulating biomarkers miR-132-3p, miR-126-3p, and miR-103a-3p were analyzed in a nested case–control study using plasma samples from 17 prediagnostic mesothelioma cases and 34 matched asbestos-exposed controls without a malignant disease. Results Using prediagnostic plasma samples collected in median 8.9 months prior the clinical diagnosis miR-132-3p, miR-126-3p, and miR-103a-3p revealed 0% sensitivity on a defined specificity of 98%. Thus, the analyzed miRNAs failed to detect the cancer in prediagnostic samples, showing that they are not feasible for the early detection of malignant mesothelioma. However, the miRNAs might still serve as possible markers for prognosis and response to therapy, but this needs to be analyzed in appropriate studies.
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- 2019
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7. Calretinin as a blood-based biomarker for mesothelioma
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Georg Johnen, Katarzyna Gawrych, Irina Raiko, Swaantje Casjens, Beate Pesch, Daniel G. Weber, Dirk Taeger, Martin Lehnert, Jens Kollmeier, Torsten Bauer, Arthur W. Musk, Bruce W. S. Robinson, Thomas Brüning, and Jenette Creaney
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Mesothelioma ,Sarcomatoid ,Epithelioid ,Biphasic ,Asbestos ,Biomarker panel ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Malignant mesothelioma (MM) is a deadly cancer mainly caused by previous exposure to asbestos. With a latency period up to 50 years the incidence of MM is still increasing, even in countries that banned asbestos. Secondary prevention has been established to provide persons at risk regular health examinations. An earlier detection with tumor markers might improve therapeutic options. Previously, we have developed a new blood-based assay for the protein marker calretinin. Aim of this study was the verification of the assay in an independent study population and comparison with the established marker mesothelin. Methods For a case-control study in men, a total of 163 cases of pleural MM and 163 controls were available from Australia, another 36 cases and 72 controls were recruited in Germany. All controls had asbestosis and/or plaques. Calretinin and mesothelin were determined by ELISA (enzyme-linked immunosorbent assay) in serum or plasma collected prior to therapy. We estimated the performance of both markers and tested factors potentially influencing marker concentrations like age, sample storage time, and MM subtype. Results Calretinin was able to detect all major subtypes except for sarcomatoid MM. Calretinin showed a similar performance in Australian and German men. At a pre-defined specificity of 95% the sensitivity of calretinin reached 71% and that of mesothelin 69%, when excluding sarcomatoid MM. At 97% specificity, the combination with calretinin increased the sensitivity of mesothelin from 66% to 75%. Sample storage time did not influence the results. In controls the concentrations of calretinin increased 1.87-fold (95% CI 1.10–3.20) per 10 years of age and slightly more for mesothelin (2.28, 95% CI 1.30–4.00). Conclusions Calretinin could be verified as a blood-based marker for MM. The assay is robust and shows a performance that is comparable to that of mesothelin. Retrospective analyses would not be limited by storage time. The high specificity supports a combination of calretinin with other markers. Calretinin is specific for epithelioid and biphasic MM but not the rarer sarcomatoid form. Molecular markers like calretinin and mesothelin are promising tools to improve and supplement the diagnosis of MM and warrant further validation in a prospective study.
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- 2017
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8. Decreased psychomotor vigilance of female shift workers after working night shifts.
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Thomas Behrens, Katarzyna Burek, Dirk Pallapies, Leoni Kösters, Martin Lehnert, Alexandra Beine, Katharina Wichert, Thomas Kantermann, Céline Vetter, Thomas Brüning, and Sylvia Rabstein
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Medicine ,Science - Abstract
BackgroundWe compared psychomotor vigilance in female shift workers of the Bergmannsheil University Hospital in Bochum, Germany (N = 74, 94% nurses) after day and night shifts.MethodsParticipants performed a 3-minute Psychomotor Vigilance Task (PVT) test bout at the end of two consecutive day and three consecutive night shifts, respectively. Psychomotor vigilance was analyzed with respect to mean reaction time, percentage of lapses and false starts, and throughput as an overall performance score, combining reaction time and error frequencies. We also determined the reaction time coefficient of variation (RTCV) to assess relative reaction time variability after day and night shifts. Further, we examined the influence of shift type (night vs. day) by mixed linear models with associated 95% confidence intervals (CI), adjusted for age, chronotype, study day, season, and the presence of obstructive sleep apnea (OSA).ResultsAt the end of a night shift, reaction times were increased (β = 7.64; 95% CI 0.94; 14.35) and the number of lapses higher compared to day shifts (exp(β) = 1.55; 95% CI 1.16-2.08). By contrast, we did not observe differences in the number of false starts between day and night shifts. Throughput was reduced after night shifts (β = -15.52; 95% CI -27.49; -3.46). Reaction times improved across consecutive day and night shifts, whereas the frequency of lapses decreased after the third night. RTCV remained unaffected by both, night shifts and consecutive shift blocks.DiscussionOur results add to the growing body of literature demonstrating that night-shift work is associated with decreased psychomotor vigilance. As the analysis of RTCV suggests, performance deficits may selectively be driven by few slow reactions at the lower end of the reaction time distribution function. Comparing intra-individual PVT-performances over three consecutive night and two consecutive day shifts, we observed performance improvements after the third night shift. Although a training effect cannot be ruled out, this finding may suggest better adaptation to the night schedule if avoiding fast-changing shift schedules.
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- 2019
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9. Value-based process project portfolio management: integrated planning of BPM capability development and process improvement
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Martin Lehnert, Alexander Linhart, and Maximilian Röglinger
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Business process management ,Capability development ,Process decision-making ,Process improvement ,Project portfolio management ,Value-based management ,Business ,HF5001-6182 - Abstract
Abstract Business process management (BPM) is an important area of organizational design and an acknowledged source of corporate performance. Over the last decades, many approaches, methods, and tools have been proposed to discover, design, analyze, enact, and improve individual processes. At the same time, BPM research has been and still is paying ever more attention to BPM itself and the development of organizations’ BPM capability. Little, however, is known about how to develop an organization’s BPM capability and improve individual processes in an integrated manner. To address this research gap, we developed a planning model. This planning model intends to assist organizations in determining which BPM- and process-level projects they should implement in which sequence to maximize their firm value, catering for the projects’ effects on process performance and for interactions among projects. We adopt the design science research (DSR) paradigm and draw from project portfolio selection as well as value-based management as justificatory knowledge. For this reason, we refer to our approach as value-based process project portfolio management. To evaluate the planning model, we validated its design specification by discussing it against theory-backed design objectives and with BPM experts from different organizations. We also compared the planning model with competing artifacts. Having instantiated the planning model as a software prototype, we validated its applicability and usefulness by conducting a case based on real-world data and by challenging the planning model against accepted evaluation criteria from the DSR literature.
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- 2016
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10. Impairment of Motor Function Correlates with Neurometabolite and Brain Iron Alterations in Parkinson’s Disease
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Beate Pesch, Swaantje Casjens, Dirk Woitalla, Shalmali Dharmadhikari, David A. Edmondson, Maria Angela Samis Zella, Martin Lehnert, Anne Lotz, Lennard Herrmann, Siegfried Muhlack, Peter Kraus, Chien-Lin Yeh, Benjamin Glaubitz, Tobias Schmidt-Wilcke, Ralf Gold, Christoph van Thriel, Thomas Brüning, Lars Tönges, and Ulrike Dydak
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Parkinson’s disease ,brain iron ,motor dysfunction ,neurometabolites ,magnetic resonance imaging ,magnetic resonance spectroscopy ,GABA ,spectroscopy ,Cytology ,QH573-671 - Abstract
We took advantage of magnetic resonance imaging (MRI) and spectroscopy (MRS) as non-invasive methods to quantify brain iron and neurometabolites, which were analyzed along with other predictors of motor dysfunction in Parkinson’s disease (PD). Tapping hits, tremor amplitude, and the scores derived from part III of the Movement Disorder Society-Sponsored Revision of the Unified Parkinson Disease Rating Scale (MDS-UPDRS3 scores) were determined in 35 male PD patients and 35 controls. The iron-sensitive MRI relaxation rate R2* was measured in the globus pallidus and substantia nigra. γ-aminobutyric acid (GABA)-edited and short echo-time MRS was used for the quantification of neurometabolites in the striatum and thalamus. Associations of R2*, neurometabolites, and other factors with motor function were estimated with Spearman correlations and mixed regression models to account for repeated measurements (hands, hemispheres). In PD patients, R2* and striatal GABA correlated with MDS-UPDRS3 scores if not adjusted for age. Patients with akinetic-rigid PD subtype (N = 19) presented with lower creatine and striatal glutamate and glutamine (Glx) but elevated thalamic GABA compared to controls or mixed PD subtype. In PD patients, Glx correlated with an impaired dexterity when adjusted for covariates. Elevated myo-inositol was associated with more tapping hits and lower MDS-UPDRS3 scores. Our neuroimaging study provides evidence that motor dysfunction in PD correlates with alterations in brain iron and neurometabolites.
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- 2019
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11. Assessment of mRNA and microRNA Stabilization in Peripheral Human Blood for Multicenter Studies and Biobanks
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Beate Pesch, Heinz Otten, Michaela Kreuzer, Maria Gomolka, Dirk Taeger, Oleksandr Bryk, Sandra Zilch- Schöneweis, Peter Rozynek, Martin Lehnert, Swaantje Casjens, Daniel Gilbert Weber, Georg Johnen, and Thomas Brüning
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Medicine (General) ,R5-920 - Published
- 2010
12. Assessment of mRNA and microRNA Stabilization in Peripheral Human Blood for Multicenter Studies and Biobanks
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Daniel Gilbert Weber, Swaantje Casjens, Peter Rozynek, Martin Lehnert, Sandra Zilch-Schöneweis, Oleksandr Bryk, Dirk Taeger, Maria Gomolka, Michaela Kreuzer, Heinz Otten, Beate Pesch, Georg Johnen, and Thomas Brüning
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Medicine (General) ,R5-920 - Abstract
In this study we evaluate the suitability of two methods of RNA conservation in blood samples, PAXgene and RNAlater, in combination with variable shipping conditions for their application in multicenter studies and biobanking. RNA yield, integrity, and purity as well as levels of selected mRNA and microRNA species were analyzed in peripheral human blood samples stabilized by PAXgene or RNAlater and shipped on dry ice or at ambient temperatures from the study centers to the central analysis laboratory. Both examined systems were clearly appropriate for RNA stabilization in human blood independently of the shipping conditions. The isolated RNA is characterized by good quantity and quality and well suited for downstream applications like quantitative RT-PCR analysis of mRNA and microRNA. Superior yield and integrity values were received using RNAlater. It would be reasonable to consider the production and approval of blood collection tubes prefilled with RNAlater to facilitate the use of this excellent RNA stabilization system in large studies.
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- 2010
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13. Beowulf: Eine Auswahl mit Einführung, teilweiser Übersetzung, Anmerkungen und etymologischem Wörterbuch
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Martin Lehnert, Martin Lehnert and Martin Lehnert, Martin Lehnert
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- 2019
14. Englisches Lehrbuch: Einführung. Sprachlehre. Gesprächsbeispiele
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Martin Lehnert and Martin Lehnert
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- 2020
15. Shakespeare
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Paul Meißner, Martin Lehnert and Paul Meißner, Martin Lehnert
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- 2020
16. Stand, Methoden und Aufgaben der Berliner Anglistischen Sprachwissenschaft
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Martin Lehnert and Martin Lehnert
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- 2020
17. Altenglisches Elementarbuch: Einführung, Grammatik, Texte mit Übersetzung und Wörterbuch
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Martin Lehnert and Martin Lehnert
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- 2019
18. Prioritization of Interconnected Processes.
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Martin Lehnert, Maximilian Röglinger, and Johannes Seyfried
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- 2018
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19. Exploring the intersection of business process improvement and BPM capability development: A research agenda.
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Martin Lehnert, Alexander Linhart, and Maximilian Roeglinger
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- 2017
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20. Kapazitätsmanagement für informationsintensive Dienstleistungen.
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Hans Ulrich Buhl, Felix Krause 0001, Martin Lehnert, and Maximilian Röglinger
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- 2015
21. Rail higher education in Europe: current situation analysis for future developments
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Arbra Bardhi, Borna Abramović, Marin Marinov, Reem Hadeed, Igor Dömény, Anna Dolinayova, Carlos Casanueva Perez, Martin Lehnert, Francesco Martini, Anne-Katrin Osdoba, Stefano Ricci, and Denis Šipuš
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railway, training, education, higher education, ERASMUS+, Europe - Abstract
The paper aims at describing the activities developed within the project ASTONRAIL (Advanced approaches and practices for rail training and education to innovate rail study programmes & improve rail higher education provision), funded by ERASMUS+ Programme. The project target is to provide a portfolio of new rail skills development strategies, approaches and professional practices in order to strengthen and modernize Europe’s current rail higher education system.
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- 2023
22. Chopping Down Trees vs. Sharpening the Axe - Balancing the Development of BPM Capabilities with Process Improvement.
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Martin Lehnert, Alexander Linhart, and Maximilian Röglinger
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- 2014
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23. V3pm: a Decision Support Tool for Value-based Process Project portfolio Management.
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Martin Lehnert, Alexander Linhart, Jonas Manderscheid, and Marius Svechla
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- 2016
24. Information Systems and Business & Information Systems Engineering: Status Quo and Outlook.
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Hans Ulrich Buhl and Martin Lehnert
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- 2012
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25. ProcessPageRank - A Network-based Approach to Process Prioritization Decisions.
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Martin Lehnert, Maximilian Roeglinger, Johannes Seyfried, and Maximilian Siegert
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- 2015
26. Lung cancer and mesothelioma risks in a prospective cohort of workers with asbestos-related lung or pleural diseases
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Dirk Taeger, Katharina Wichert, Martin Lehnert, Swaantje Casjens, Beate Pesch, Daniel G. Weber, Thomas Brüning, Georg Johnen, and Thomas Behrens
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Male ,Mesothelioma ,Occupational Diseases ,Lung Neoplasms ,Occupational Exposure ,Pleural Neoplasms ,Mesothelioma, Malignant ,Public Health, Environmental and Occupational Health ,Humans ,Asbestos ,Prospective Studies ,Pleural Diseases ,Lung - Abstract
Asbestos causes mesothelioma and lung cancer. In the European Union, asbestos was banned in 2005, but it is still in use in many other countries. The aim of this study was to estimate the lung cancer and mesothelioma incidence risk of men with benign asbestos-related lung or pleural diseases.Between 2008 and 2018, 2439 male participants of a German surveillance program for asbestos workers were included in the cohort. All participants had a recognized occupational asbestos-related disease of the pleura or lung. We estimated the mesothelioma and lung cancer risks by calculating standardized incidence ratios (SIR) with corresponding 95% confidence intervals (95% CI).We observed 64 incident lung cancer and 40 mesothelioma cases in the cohort. An SIR of 17.60 (95% CI: 12.57-23.96) was estimated for mesothelioma and 1.27 (95% CI: 0.98-1.62) for lung cancer. The presence of pleural plaques was associated with a strongly increased risk (SIR: 13.14; 95% CI: 8.51-19.40) for mesothelioma, but not for lung cancer (SIR: 1.05; 95% CI: 0.76-1.41). The highest lung-cancer risk (SIR: 2.56; 95% CI 1.10-5.04) was revealed for cohort members with less than 40 years since first asbestos exposure. Lung cancer risks by duration of asbestos exposure did not show a consistent time trend, but for time since last exposure a trend for mesothelioma was seen.Compared to the general population, we demonstrated an association between benign asbestos-related lung or pleural disease and mesothelioma risk in workers with a history of occupational asbestos exposure. Because lung-cancer risk is dominated by smoking habits, a possible effect of asbestos exposure may have been masked. Efforts should be made to ban production and use of asbestos worldwide and to establish safe handling rules of legacy asbestos.
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- 2022
27. Association of exposure to manganese and fine motor skills in welders - Results from the WELDOX II study
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Chien-Lin Yeh, Tobias Schmidt-Wilcke, Swaantje Casjens, Maria Angela Samis Zella, Anne Lotz, Thomas Behrens, Christoph van Thriel, Dirk Woitalla, Beate Pesch, Martin Lehnert, Thomas Brüning, Wolfgang Zschiesche, Tobias Weiss, Dirk Taeger, Ulrike Dydak, Stefan Gabriel, and Clara Quetscher
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medicine.medical_specialty ,chemistry.chemical_element ,Neuroimaging ,Manganese ,Audiology ,Toxicology ,Article ,Part iii ,03 medical and health sciences ,0302 clinical medicine ,Occupational Exposure ,medicine ,Humans ,030304 developmental biology ,Fine motor ,0303 health sciences ,Motor test ,medicine.diagnostic_test ,Fine motor functions ,Metal Workers ,business.industry ,Manganese Poisoning ,General Neuroscience ,Brain ,Magnetic resonance imaging ,Middle Aged ,Magnetic Resonance Imaging ,Globus pallidus ,chemistry ,Motor Skills ,Case-Control Studies ,business ,030217 neurology & neurosurgery - Abstract
The aim of this study was to evaluate the effect of exposure to manganese (Mn) on fine motor functions. A total of 48 welders and 30 unexposed workers as controls completed questionnaires, underwent blood examinations, and a motor test battery. The shift exposure of welders to respirable Mn was measured with personal samplers. For all subjects accumulations of Mn in the brain were assessed with T1-weighted magnetic resonance imaging. Welders showed normal motor functions on the Movement Disorder Society-Sponsored Revision of the Unified Parkinson Disease Rating Scale part III. Furthermore welders performed excellent on a steadiness test, showing better results than controls. However, welders were slightly slower than controls in motor tests. There was no association between fine motor test results and the relaxation rates R1 in globus pallidus and substantia nigra as MRI-based biomarkers to quantify Mn deposition in the brain.
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- 2021
28. The Future of Business Process Management in the Future of Work.
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Georgi Kerpedzhiev, Martin Lehnert, and Maximilian Röglinger
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- 2016
29. Altenglisches Elementarbuch: Einführung, Grammatik, Texte mit Übersetzung und Wörterbuch
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Martin Lehnert and Martin Lehnert
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- 2012
30. Transcendence without difference? Reflections on the Vajracchedikā-prajñāpāramitā
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Martin Lehnert
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Psychoanalysis ,Transcendence (philosophy) ,Philosophy - Published
- 2021
31. Differences in twenty-four-hour profiles of blue-light exposure between day and night shifts in female medical staff
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Dirk Pallapies, Thomas Behrens, Céline Vetter, Martin Lehnert, Simone Putzke, Thomas Kantermann, Volker Harth, Alexandra Beine, J. W. Walther, Katarzyna Burek, Thomas Brüning, Rui Wang-Sattler, and Sylvia Rabstein
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Adult ,Environmental Engineering ,Evening ,010504 meteorology & atmospheric sciences ,010501 environmental sciences ,01 natural sciences ,Shift work ,Animal science ,Germany ,Zeitgeber ,Humans ,Environmental Chemistry ,Medicine ,Circadian rhythm ,Waste Management and Disposal ,0105 earth and related environmental sciences ,Blue light ,Morning ,business.industry ,Shift Work Schedule ,Chronotype ,Middle Aged ,Radiation Exposure ,Pollution ,Circadian Rhythm ,Personnel, Hospital ,Darkness ,Linear Models ,Female ,business - Abstract
Light is the strongest zeitgeber currently known for the synchronization of the human circadian timing system. Especially shift workers are exposed to altered daily light profiles. Our objective is the characterization of differences in blue-light exposures between day and night shift taking into consideration modifying factors such as chronotype. We describe 24-hour blue-light profiles as measured with ambient light data loggers (LightWatcher) during up to three consecutive days with either day or night shifts in 100 female hospital staff including 511 observations. Linear mixed models were applied to analyze light profiles and to select time-windows for the analysis of associations between shift work, individual factors, and log mean light exposures as well as the duration of darkness per day. Blue-light profiles reflected different daily activities and were mainly influenced by work time. Except for evening (7–9 p.m.), all time windows showed large differences in blue-light exposures between day and night shifts. Night work reduced the duration of darkness per day by almost 4 h ( β ^ = −3:48 hh:mm, 95% CI (−4:27; −3.09)). Late chronotypes had higher light exposures in the morning and evening compared to women with intermediate chronotype (e.g. morning β ^ = 0.50 log(mW/m2/nm), 95% CI (0.08; 0.93)). Women with children had slightly higher light exposures in the afternoon than women without children ( β ^ = 0.48, 95% CI (−0.10; 1,06)). Time windows for the description of light should be chosen carefully with regard to timing of shifts. Our results are helpful for future studies to capture relevant light exposure differences and potential collinearities with individual factors. Improvement of well-being of shift workers with altered light profiles may therefore require consideration of both – light at the workplace and outside working hours.
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- 2019
32. How to Reduce the Exposure of Welders to an Acceptable Level: Results of the InterWeld Study
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Martin Lehnert, Thomas Behrens, Benjamin Kendzia, Wolfgang Zschiesche, Thomas Brüning, Johannes Pelzer, Dirk Taeger, and Arno Goebel
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Face shield ,business.product_category ,Metal Workers ,Metallurgy ,technology, industry, and agriculture ,Public Health, Environmental and Occupational Health ,Pilot Projects ,Welding ,Air Pollutants, Occupational ,Welding fume ,law.invention ,Gas metal arc welding ,chemistry.chemical_compound ,chemistry ,law ,Occupational Exposure ,Ventilation (architecture) ,Environmental science ,Humans ,Occupational exposure limit ,Hexavalent chromium ,High flow ,business - Abstract
Objectives Workplace measurements in the past have shown that the applicable occupational exposure limits (OELs) are regularly exceeded in practice when high-emission welding processes are applied. The InterWeld pilot study was planned as part of an intervention study to show under which conditions compliance with the OEL is achievable in gas metal arc welding (GMAW) with solid wire. The investigation focussed on local exhaust ventilation, i.e. captor hoods and welding torches with integrated fume extraction. Methods Forty tests with hand-guided GMAW were configured by experts with regard to all technical parameters and carried out by a professional welder. Effects of protective measures and process parameters on the exposure to respirable welding fumes and airborne manganese (Mn), chromium, nickel, and hexavalent chromium were investigated. Personal sampling was carried out in the welder’s breathing zone outside the face shield at high flow rates (10 l min−1) in order to achieve sufficient filter loading. Particle masses and welding fume concentrations were determined by weighing the sampling filters. Metal concentrations were analysed by inductive coupled plasma mass spectrometry. In order to evaluate the effects on exposure, the measurements were performed under similar conditions. The data were analysed descriptively and with mixed linear models. For measurements below the limit of detection, the exposure level was estimated using multiple imputation. Results Two to five times higher exposures to respirable welding fumes and airborne metals were observed during welding of 10 mm sheets than during welding of 2- or 3-mm sheets. Welding fume and Mn exposure were reduced by 70 and 90% when on-torch extraction or a captor hood was applied. Other airborne metals were reduced to a similar extent. Modifications on welding parameters led to a reduction of exposure against respirable particles by 51 up to 54%. Conclusions Although proper extraction at the point of origin and lower-emitting process variants ensure a drastic reduction in exposure, compliance with current OELs is not guaranteed. In order to ensure adequate health protection, especially at workplaces where thick sheets with long relative arc times are processed, there is a need for technical development.
- Published
- 2020
33. Self-Reported Survey on Allergy Symptoms Among First-Year Students in Veterinary Medicine: A Preamble to the AllergoVet Cohort Study
- Author
-
Martin, Lehnert, Alexandra, Beine, Frank, Hoffmeyer, Dirk, Taeger, Thomas, Brüning, and Monika, Raulf
- Subjects
Male ,Students, Health Occupations ,Young Adult ,Hypersensitivity ,Prevalence ,Humans ,Female ,Longitudinal Studies ,Prospective Studies ,Self Report ,Allergens ,Education, Veterinary ,Health Surveys - Abstract
Practical work in veterinary medicine provides exposure to various allergens which could increase the risk of sensitization. With the ongoing prospective "AllergoVet" study, we are investigating patterns of allergic symptoms and sensitization among veterinary students. Here, we report the results of the introductory self-reported survey on the presence of allergies in the first-year students of veterinary medicine, who had begun their studies in the years 2013-2016. The survey included 553 students who answered a questionnaire (63% response rate, 83% female ratio). The median age was 20 years (IQR: 19-22 years). About half of the responders indicated an interest in participating in the prospective study ("candidates"). Those who were uninterested in participating were termed "noncandidates". A doctor's diagnosis of any kind of atopic disease was reported by every fourth student. Hay fever was reported by 71 (13%) and allergic asthma by 38 (6.9%) students. The prevalence of hay fever in "candidates" (n = 294) and "noncandidates" (n = 259) was 13.5% and 12.2%, respectively. Allergic asthma was reported by 9.9% of "candidates" and 3.5% of "noncandidates", the difference being significant (p = 0.003). We conclude that the prevalence of self-reported allergic symptoms in the first-year students of veterinary medicine is similar to that in the general population. Pre-existing allergic asthma may have increased the motivation for the enrolment into the longitudinal "AllergoVet-study".
- Published
- 2020
34. Krebs in der Glasindustrie – eine systematische Übersicht und Meta-Analyse
- Author
-
T. Brüning, Dirk Taeger, Thomas Behrens, K Guldner, and Martin Lehnert
- Published
- 2020
35. Foundational Narratives in Chan/Zen Buddhism and the Observation of the Ineffable: Two 'Public Cases' (gong’an/kōan) of the Gateless Barrier of Chan Lineage
- Author
-
Martin Lehnert
- Subjects
Cultural history ,Lineage (genetic) ,History ,Buddhism ,Narrative ,Memory studies ,Genealogy - Published
- 2020
36. The Pattern of Sensitization Influences Exhaled and Nasal Nitric Oxide Levels in Young Adults
- Author
-
Eva Zahradnik, V. van Kampen, T. Brüning, Hans Berresheim, Dirk Taeger, Martin Lehnert, Monika Raulf, Ingrid Sander, Alexandra Beine, and Frank Hoffmeyer
- Subjects
House dust mite ,biology ,Inhalation ,business.industry ,respiratory system ,medicine.disease_cause ,Immunoglobulin E ,biology.organism_classification ,medicine.disease ,respiratory tract diseases ,Atopy ,03 medical and health sciences ,0302 clinical medicine ,Allergen ,medicine.anatomical_structure ,Immunology ,Exhaled nitric oxide ,medicine ,biology.protein ,030212 general & internal medicine ,Analysis of variance ,business ,Sensitization - Abstract
Nitric oxide (NO) from upper (nasal NO, nNO) or lower airways (fractional exhaled NO, FeNO) is considered a surrogate marker for Th2-type inflammation, which is influenced by atopy. The aim of this study was to analyze nNO and FeNO in regard to qualitative and quantitative aspects of sensitization. We evaluated 244 non-smoking young adults. All of them were first-year students recruited for a longitudinal study. An inhalation allergy screening tool was used for atopy definition (specific immunoglobulin E (sIgE) to sx1 ≥ 0.35 kU/L), and also sIgE response to three inhalant perennial allergens, house dust mite (HDM, d1), cat (e1), and dog (e5), was determined in the non-pollen season. With respect to sx1, 100 subjects could be classified as atopic. Sensitization to one, two, or three perennial allergens could be demonstrated in 46, 10, and 16 students, respectively. The subjects with positive IgE response to sx1, but not sensitized to HDM, cat, and/or dog, had FeNO levels comparable to those of non-atopic subjects (13.5 vs. 13.0 ppb, respectively; p = 0.485). These levels were significantly lower compared to atopic subjects being sensitized to any perennial allergen (19.0 ppb; p = 0.0003). After grouping the atopic subjects for perennial sensitization patterns, significantly higher FeNO could be detected in subjects with poly-sensitization (n = 26; 26.0 ppb) compared to the mono-sensitized ones (n = 46; 18.0 ppb; p = 0.023). Regarding nNO, no differences could be observed. Applying a two-way ANOVA, we could reveal a significant correlation of specific HDM-IgE CAP-class with FeNO (p < 0.0001) and nNO levels (p = 0.007). Finally, a significant relationship was found between nNO and FeNO for the whole cohort (p < 0.0001). In summary, our findings support the argument that atopy and perennial sensitization should be considered for the interpretation of NO.
- Published
- 2020
37. Self-Reported Survey on Allergy Symptoms Among First-Year Students in Veterinary Medicine: A Preamble to the AllergoVet Cohort Study
- Author
-
Frank Hoffmeyer, Martin Lehnert, Thomas Brüning, Alexandra Beine, Monika Raulf, and Dirk Taeger
- Subjects
Response rate (survey) ,Veterinary medicine ,education.field_of_study ,Allergy ,business.industry ,Population ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Allergic symptoms ,medicine ,Hay fever ,030212 general & internal medicine ,education ,Prospective cohort study ,business ,Asthma ,Cohort study - Abstract
Practical work in veterinary medicine provides exposure to various allergens which could increase the risk of sensitization. With the ongoing prospective “AllergoVet” study, we are investigating patterns of allergic symptoms and sensitization among veterinary students. Here, we report the results of the introductory self-reported survey on the presence of allergies in the first-year students of veterinary medicine, who had begun their studies in the years 2013–2016. The survey included 553 students who answered a questionnaire (63% response rate, 83% female ratio). The median age was 20 years (IQR: 19–22 years). About half of the responders indicated an interest in participating in the prospective study (“candidates”). Those who were uninterested in participating were termed “noncandidates”. A doctor’s diagnosis of any kind of atopic disease was reported by every fourth student. Hay fever was reported by 71 (13%) and allergic asthma by 38 (6.9%) students. The prevalence of hay fever in “candidates” (n = 294) and “noncandidates” (n = 259) was 13.5% and 12.2%, respectively. Allergic asthma was reported by 9.9% of “candidates” and 3.5% of “noncandidates”, the difference being significant (p = 0.003). We conclude that the prevalence of self-reported allergic symptoms in the first-year students of veterinary medicine is similar to that in the general population. Pre-existing allergic asthma may have increased the motivation for the enrolment into the longitudinal “AllergoVet-study”.
- Published
- 2020
38. Betriebliche Effizienzgrößen für Ridepooling-Systeme
- Author
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Christian Mehlert, Christian Liebchen, Martin Schiefelbusch, and Martin Lehnert
- Subjects
ddc:629 ,629 Andere Fachrichtungen der Ingenieurwissenschaften - Abstract
Ridepooling stellt eine viel diskutierte Mobilitätsform dar. Ad-hoc und in der Regel von mobilen Endgeräten übermittelte Fahrtwünsche einzelner Fahrgäste werden bedarfsgesteuert, fahrplanfrei und vollflexibel zu möglichst effizienten, geteilten Fahrten gebündelt, welche im Regelfall mit Vans oder Kleinbussen durchgeführt werden. Sowohl aus Betreibersicht als auch insbesondere aus der Sicht von Genehmigungsbehörden stellt sich dabei die Frage nach der betrieblichen Effizienz von Ridepooling-Systemen, welche nicht zuletzt für die Bewertung der Konformität zu öffentlichen Verkehrsinteressen, speziell einer effizienten Nutzung öffentlicher Verkehrsinfrastruktur, relevant sein können. In diesem Zuge werden teilweise auch bereits Aspekte wie Umwegfaktor, Besetzungsgrad und Leerkilometeranteil diskutiert. Im vorliegenden Beitrag werden diese Aspekte als ein Teilergebnis der Arbeit des FGSV-Arbeitskreises 1.6.1 "Verkehrliche Anforderungen an Ridepooling-Systeme" zu einem Kennzahlensystem zusammengefügt, die vollständigen Ausführungen finden sich dabei in Liebchen et al. (2020).
- Published
- 2020
39. Association of exposure to manganese and iron with striatal and thalamic GABA and other neurometabolites — Neuroimaging results from the WELDOX II study
- Author
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Dirk Woitalla, Shalmali Dharmadhikari, Chien-Lin Yeh, Swaantje Casjens, Christoph van Thriel, Siegfried Muhlack, Anne Lotz, Tobias Weiss, Lennard Herrmann, Clara Quetscher, Thomas Brüning, Michael Aschner, David A. Edmondson, Martin Lehnert, Urike Dydak, Tobias Schmidt-Wilcke, Christoph Stewig, Benjamin Glaubitz, and Beate Pesch
- Subjects
Male ,0301 basic medicine ,medicine.medical_specialty ,Magnetic Resonance Spectroscopy ,Iron ,Glutamic Acid ,Air Pollutants, Occupational ,Striatum ,Toxicology ,Creatine ,Article ,gamma-Aminobutyric acid ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Nuclear magnetic resonance ,Cerebrospinal fluid ,Thalamus ,Occupational Exposure ,Internal medicine ,medicine ,Humans ,Welding ,gamma-Aminobutyric Acid ,Hemochromatosis ,Manganese ,biology ,General Neuroscience ,Glutamate receptor ,Middle Aged ,medicine.disease ,Corpus Striatum ,Ferritin ,030104 developmental biology ,Globus pallidus ,Endocrinology ,nervous system ,chemistry ,biology.protein ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Objective Magnetic resonance spectroscopy (MRS) is a non-invasive method to quantify neurometabolite concentrations in the brain. Within the framework of the WELDOX II study, we investigated the association of exposure to manganese (Mn) and iron (Fe) with γ-aminobutyric acid (GABA) and other neurometabolites in the striatum and thalamus of 154 men. Material and methods GABA-edited and short echo-time MRS at 3T was used to assess brain levels of GABA, glutamate, total creatine (tCr) and other neurometabolites. Volumes of interest (VOIs) were placed into the striatum and thalamus of both hemispheres of 47 active welders, 20 former welders, 36 men with Parkinson’s disease (PD), 12 men with hemochromatosis (HC), and 39 male controls. Linear mixed models were used to estimate the influence of Mn and Fe exposure on neurometabolites while simultaneously adjusting for cerebrospinal fluid (CSF) content, age and other factors. Exposure to Mn and Fe was assessed by study group, blood concentrations, relaxation rates R1 and R2* in the globus pallidus (GP), and airborne exposure (active welders only). Results The median shift exposure to respirable Mn and Fe in active welders was 23 μg/m3 and 110 μg/m3, respectively. Airborne exposure was not associated with any other neurometabolite concentration. Mn in blood and serum ferritin were highest in active and former welders. GABA concentrations were not associated with any measure of exposure to Mn or Fe. In comparison to controls, tCr in these VOIs was lower in welders and patients with PD or HC. Serum concentrations of ferritin and Fe were associated with N-acetylaspartate, but in opposed directions. Higher R1 values in the GP correlated with lower neurometabolite concentrations, in particular tCr (exp(β) = 0.87, p Conclusions Our results do not provide evidence that striatal and thalamic GABA differ between Mn-exposed workers, PD or HC patients, and controls. This may be due to the low exposure levels of the Mn-exposed workers and the challenges to detect small changes in GABA. Whereas Mn in blood was not associated with any neurometabolite content in these VOIs, a higher metal accumulation in the GP assessed with R1 correlated with generally lower neurometabolite concentrations.
- Published
- 2018
40. Der angloamerikanische Einfluß auf die Sprache der beiden deutschen Staaten
- Author
-
Martin Lehnert and Martin Lehnert
- Published
- 1991
41. Prioritization of Interconnected Processes
- Author
-
Martin Lehnert, Johannes Seyfried, and Maximilian Röglinger
- Subjects
Process management ,Artifact-centric business process model ,business.industry ,Business process ,Computer science ,Process (engineering) ,Design specification ,02 engineering and technology ,Business process modeling ,Business process discovery ,Business Process Model and Notation ,Business process management ,Software ,020204 information systems ,Business architecture ,0202 electrical engineering, electronic engineering, information engineering ,020201 artificial intelligence & image processing ,Performance indicator ,business ,Information Systems - Abstract
Deciding which business processes to improve is a challenge for all organizations. The literature on business process management (BPM) offers several approaches that support process prioritization. As many approaches share the individual process as unit of analysis, they determine the processes’ need for improvement mostly based on performance indicators, but neglect how processes are interconnected. So far, the interconnections of processes are only captured for descriptive purposes in process model repositories or business process architectures (BPAs). Prioritizing processes without catering for their interconnectedness, however, biases prioritization decisions and causes a misallocation of corporate funds. What is missing are process prioritization approaches that consider the processes’ individual need for improvement and their interconnectedness. To address this research problem, the authors propose the ProcessPageRank (PPR) as their main contribution. The PPR prioritizes processes of a given BPA by ranking them according to their network-adjusted need for improvement. The PPR builds on knowledge from process performance management, BPAs, and network analysis – particularly the Google PageRank. As for evaluation, the authors validated the PPR’s design specification against empirically validated and theory-backed design propositions. They also instantiated the PPR’s design specification as a software prototype and applied the prototype to a real-world BPA.
- Published
- 2017
42. Exploring the intersection of business process improvement and BPM capability development
- Author
-
Alexander Linhart, Martin Lehnert, and Maximilian Roeglinger
- Subjects
Process management ,Knowledge management ,Performance management ,Business process ,business.industry ,Computer science ,Application portfolio management ,Business object ,05 social sciences ,02 engineering and technology ,Work in process ,Business process modeling ,Business process management ,0502 economics and business ,0202 electrical engineering, electronic engineering, information engineering ,Business, Management and Accounting (miscellaneous) ,020201 artificial intelligence & image processing ,Business and International Management ,Project portfolio management ,business ,050203 business & management - Abstract
Purpose Despite an obvious connection, business process improvement and business process management (BPM) capability development have been studied intensely, but in isolation. The authors thus aim to make the case for the research located at the intersection of both streams. The authors thereby focus on the integrated planning of business process improvement and BPM capability development as this is where, in the authors’ opinion, both streams have the closest interaction. The authors refer to the research field located at the intersection of business process improvement and BPM capability development as process project portfolio management. The paper aims to discuss these issues. Design/methodology/approach The authors structure the field of process project portfolio management drawing from extant knowledge related to BPM, project portfolio management, and performance management. The authors also propose a research agenda in terms of exemplary research questions and research methods. Findings The proposed structure shows which business objects and interactions should be considered when engaging in process project portfolio management. The research agenda contains exemplary questions structured along the intersections of BPM, project portfolio management, and performance management. Research limitations/implications This paper’s main limitation is that it reflects the authors’ individual viewpoints based on experiences of several industry projects and prior research. Originality/value This paper addresses a neglected research field, opens up new avenues for interdisciplinary BPM research, and contributes a novel perspective to the ongoing discussion about the future of BPM.
- Published
- 2017
43. Incidence of malignant mesothelioma in Germany 2009–2013
- Author
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Martin Lehnert, Evelyn Heinze, Georg Johnen, Julia Fiebig, Klaus Kraywinkel, Thomas Brüning, Thorsten Wiethege, and Dirk Taeger
- Subjects
Adult ,Male ,Mesothelioma ,Cancer Research ,medicine.medical_specialty ,Lung Neoplasms ,Population ,medicine.disease_cause ,Asbestos ,German ,03 medical and health sciences ,0302 clinical medicine ,Germany ,Occupational Exposure ,Epidemiology ,medicine ,Humans ,Registries ,030212 general & internal medicine ,education ,Aged ,Aged, 80 and over ,education.field_of_study ,business.industry ,Incidence ,Public health ,Incidence (epidemiology) ,Middle Aged ,medicine.disease ,language.human_language ,Surgery ,Oncology ,030220 oncology & carcinogenesis ,language ,Female ,Residence ,business ,Demography - Abstract
The malignant mesothelioma is a rare malignancy and mainly caused by occupational exposure to asbestos. German cancer registries are providing a national database to investigate temporal and regional patterns of mesothelioma incidence. These may be of interest for healthcare planning and for surveillance programs aiming at the formerly exposed workforce. We analyzed population-based incidence data of malignant mesothelioma by site, type, sex, age, as well as district and state of patient’s residence. Age-standardized incidence rates (AIRs40+) were calculated according to the European standard population truncated to the age of 40 years and older. We present rates at national, state, and district level and trends of incidence of northern states of Germany. In total, 7,547 malignant mesotheliomas were reported to German cancer registries diagnosed between 2009 and 2013—90% located to the pleura. On average, 1,198 men and 312 women were affected each year. We estimated AIR40+ of 4.77 in 100,000 German men and 0.98 in 100,000 German women. Regional clusters were predominantly located to the seaports of West Germany. The highest regional AIR40+ was 20 per 100,000 men. Corresponding rates in northeast Germany were between 2 and 4 per 100,000 men. Regional clusters of high incidence indicate districts with former shipyards and steel industry, but predominantly in the western part of Germany. The West-to-East difference corresponds to patterns of mortality. Twenty years after banning asbestos in Germany, Bremen and Hamburg are presenting the highest mesothelioma incidence but show steadily decreasing trends.
- Published
- 2016
44. Empreintes du tantrisme en Chine et en Asie orientale: Imaginaires, rituels, influences by Vincent Durand-Dastès
- Author
-
Martin Lehnert
- Subjects
Religious studies - Published
- 2018
45. Exposure to welding fumes suppresses the activity of T-helper cells
- Author
-
Jürgen Knobloch, Juliane Kronsbein, S Yanik, S Körber, Beate Pesch, Martin Lehnert, Swaantje Casjens, Andrea Koch, Wolfgang Zschiesche, Anne Lotz, Monika Raulf, Tobias Weiss, Thomas Brüning, and Jan Rupp
- Subjects
Lipopolysaccharide ,Iron ,Pulmonary disease ,Air Pollutants, Occupational ,010501 environmental sciences ,Welding fume ,medicine.disease_cause ,01 natural sciences ,Biochemistry ,Haemophilus influenzae ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Immune system ,Occupational Exposure ,otorhinolaryngologic diseases ,medicine ,Cigarette smoke ,Welding ,030212 general & internal medicine ,0105 earth and related environmental sciences ,General Environmental Science ,Inhalation Exposure ,COPD ,business.industry ,T-Lymphocytes, Helper-Inducer ,medicine.disease ,chemistry ,Immunology ,Gases ,business ,Ex vivo - Abstract
Welders have an increased susceptibility to airway infections with non-typeable Haemophilus influenzae (NTHi), which implicates immune defects and might promote pneumonia and chronic obstructive pulmonary disease (COPD). We hypothesized that welding-fume exposure suppresses Th1-lymphocyte activity. Non-effector CD4+ T-cells from blood of 45 welders (n = 23 gas metal arc welders, GMAW; n = 16 tungsten inert gas welders, TIG; n = 6 others) and 25 non-welders were ex vivo activated towards Th1 via polyclonal T-cell receptor stimulation and IL-12 (first activation step) and then stimulated with NTHi extract or lipopolysaccharide (LPS) (second activation step). IFNγ and IL-2 were measured by ELISA. In the first activation step, IFNγ was reduced in welders compared to non-welders and in the GMAW welders with higher concentrations of respirable particles compared to the lower exposed TIG welders. IFNγ was not influenced by tobacco smoking and correlated negatively with welding-fume exposure, respirable manganese, and iron. In the second activation step, NTHi and LPS induced additional IFNγ, which was reduced in current smokers compared to never smokers in welders as well as in non-welders. Analyzing both activation steps together, IFNγ production was lowest in smoking welders and highest in never smoking non-welders. IL-2 was not associated with any of these parameters. Welding-fume exposure might suppress Th1-based immune responses due to effects of particulate matter, which mainly consists of iron and manganese. For responses to NTHi this is strongest in smoking welders because welding fume suppresses T-cell activation towards Th1 and cigarette smoke suppresses the subsequent Th1-response to NTHi via LPS. Both effects are independent from IL-2-regulated T-cell proliferation. This might explain the increased susceptibility to infections and might promote COPD development.
- Published
- 2020
46. Cancer in glass workers: a systematic review and meta-analysis
- Author
-
Karlheinz Guldner, Justus Tulowietzki, Martin Lehnert, Dirk Taeger, Thomas Brüning, and Thomas Behrens
- Subjects
Male ,medicine.medical_specialty ,Lung Neoplasms ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Neoplasms ,Occupational Exposure ,Manufacturing Industry ,medicine ,Humans ,030212 general & internal medicine ,Combined result ,Lung cancer ,Laryngeal Neoplasms ,business.industry ,Incidence (epidemiology) ,Incidence ,Public Health, Environmental and Occupational Health ,Cancer ,Odds ratio ,medicine.disease ,030210 environmental & occupational health ,Standardized mortality ratio ,Meta-analysis ,Glass ,business ,Cohort study - Abstract
Due to a potential exposure to several definite or probable carcinogens, the IARC classified manufacturing of art glass, glass containers, and pressed ware as probably carcinogenic to humans in 1993 (Group 2A). Purpose of this study was to update the evidence from recently published scientific reports. We searched for peer-reviewed articles published between 1993 and 2018 and combined result in terms of a meta-analysis. Overall, we considered twelve articles for a meta-analytic approach published after 1992. From a meta-analysis we derived a standardized incidence ratio (mSIR) and a standardized mortality ratio (mSMR) for lung cancer in men of 1.25 (95% CI 0.97–1.59) and 1.41 (95% CI 1.11–1.77), respectively. The estimated odds ratio (mOR) from five case–control studies was 1.25 (95% CI 0.90–1.73). Associated with an employment in glass factories, the estimated mSMR for larynx cancer was 2.38 (95% CI 1.23–4.16) based on two cohort studies; the mOR from four case–control studies was 1.35 (95% CI 0.73–2.52). Reports on elevated cancer risks at other sites were not consistent. Only few studies assessed cancer risk solely in glass workers. Gained evidence from more recent reports supports the IARC rating from 1993. Our combined results add limited evidence to a moderately elevated risk for cancer of the airways.
- Published
- 2018
47. Information Systems and Business & Information Systems Engineering: Status Quo and Outlook
- Author
-
Martin Lehnert and Hans Ulrich Buhl
- Subjects
Management information systems ,Knowledge management ,business.industry ,Status quo ,media_common.quotation_subject ,Common object ,Information system ,Relevance (information retrieval) ,Information systems engineering ,Scenario analysis ,business ,Critical reflection ,media_common - Abstract
Although both communities share a common object of research, the Business and Information Systems Engineering (BISE) community from the German-speaking countries and the Information Systems (IS) community centered in North America have developed quite differently. The BISE community features promote connections with industry, attractive topics to students and practical relevance of publications. But due to various reasons numerous BISE researchers struggle with publications in top-ranked journals. While this weakness obviously is a strength of the IS community, we observe that the IS community struggles with its industry connections and enrollment numbers. What the global IS/BISE community needs is a more intense discourse that increases mutual understanding, creates awareness for the need for complementation, and ensures that the opportunity for complementation is seized. This paper offers insights on how by complementation both communities could mitigate some of their weaknesses and the global IS/BISE community could increase its success as a whole.
- Published
- 2018
48. Prediagnostic detection of mesothelioma by circulating calretinin and mesothelin - a case-control comparison nested into a prospective cohort of asbestos-exposed workers
- Author
-
Georg Johnen, Katarzyna Burek, Irina Raiko, Katharina Wichert, Beate Pesch, Daniel G. Weber, Martin Lehnert, Swaantje Casjens, Olaf Hagemeyer, Dirk Taeger, Thomas Brüning, and MoMar Study Group
- Subjects
Aged, 80 and over ,Male ,Mesothelioma ,Lung Neoplasms ,Incidence ,lcsh:R ,Mesothelioma, Malignant ,lcsh:Medicine ,Asbestos ,Middle Aged ,GPI-Linked Proteins ,Prognosis ,Cohort Studies ,Calbindin 2 ,Case-Control Studies ,Mesothelin ,Occupational Exposure ,Humans ,lcsh:Q ,Female ,Prospective Studies ,lcsh:Science ,Aged - Abstract
Malignant mesothelioma (MM) is strongly associated with a previous asbestos exposure. To improve timely detection of MM in asbestos workers, better screening tools – like minimally-invasive biomarkers – are desirable. Between 2008 and 2018 2,769 patients with benign asbestos-related diseases were recruited to participate in annual screens. Using a nested case-control design the protein markers calretinin and mesothelin were determined by enzyme-linked immunosorbent assays in prediagnostic plasma samples of 34 MM cases as well as 136 matched controls from the cohort. Conditional on a pre-defined specificity of 98% for calretinin and 99% for mesothelin the markers reached individual sensitivities of 31% and 23%, respectively, when including the incident cases with samples taken between one and 15 months before diagnosis. The combination of both markers increased the sensitivity to 46% at 98% specificity. Marker complementation increased with earlier sampling. The marker combination improves the sensitivity of the individual markers, indicating a useful complementation and suggesting that additional markers may further improve the performance. This is the first prospective cohort study to evaluate a detection of MM by calretinin and its combination with mesothelin up to about a year before clinical diagnosis. Whether an earlier diagnosis will result in reduced mortality has yet to be demonstrated.
- Published
- 2018
49. Vitamin D supply in shift working nurses
- Author
-
Alexandra Beine, Sylvia Rabstein, Katarzyna Burek, Thomas Behrens, Simone Putzke, Dirk Pallapies, Martin Lehnert, Thomas Brüning, and Stephan Schlösser
- Subjects
Adult ,Time Factors ,Physiology ,Cross-sectional study ,Physical activity ,Body Mass Index ,Shift work ,03 medical and health sciences ,0302 clinical medicine ,Physiology (medical) ,Female health ,Environmental health ,Germany ,Vitamin D and neurology ,Prevalence ,Medicine ,Humans ,030212 general & internal medicine ,Obesity ,Vitamin D ,Occupational Health ,business.industry ,Shift Work Schedule ,Middle Aged ,Vitamin D Deficiency ,Cross-Sectional Studies ,Cohort ,Biomarker (medicine) ,Female ,Nursing Staff ,Seasons ,business ,Body mass index ,030217 neurology & neurosurgery ,Biomarkers - Abstract
We studied determinants of Vitamin D in serum of 67 female health care workers (aged 25-60 years), including age, body mass index, physical activity, and shift work. Overall, vitamin D levels were low, ranging from 6 to 51 ng/mL (median: 20 ng/mL). Lower serum levels were found in samples drawn in winter and spring and in obese subjects. Shift work had only small effects on vitamin D levels. The high prevalence of vitamin D undersupply is in line with observations from the German general population. Vitamin D supply particularly in winter and spring should be ensured to avoid health problems.
- Published
- 2018
50. Exposure to hexavalent chromium in welders: Results of the WELDOX II field study
- Author
-
Anne Lotz, Evelyn Heinze, Thomas Behrens, Tobias Weiss, Stefan Gabriel, Benjamin Kendzia, Wolfgang Schneider, Beate Pesch, Martin Lehnert, Thomas Brüning, and Eleonore Menne
- Subjects
Adult ,Chromium ,Male ,Shielded metal arc welding ,Welding ,Urine ,Air Pollutants, Occupational ,010501 environmental sciences ,01 natural sciences ,law.invention ,Gas metal arc welding ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,law ,Nickel ,Occupational Exposure ,Humans ,Hexavalent chromium ,0105 earth and related environmental sciences ,Detection limit ,Chromate conversion coating ,Gas tungsten arc welding ,Public Health, Environmental and Occupational Health ,Middle Aged ,Stainless Steel ,030210 environmental & occupational health ,chemistry ,Gases ,Nuclear chemistry ,Environmental Monitoring - Abstract
Objectives Exposure to hexavalent chromium (Cr(VI)) has been primarily studied in chromate production. Here, we measured personal exposure to respirable Cr(VI) together with airborne and urinary Cr and Ni in welders to explore levels and associations between various measures of exposure. Methods Shift concentrations of Cr(VI), Cr, and Ni were measured in respirable welding fumes in 50 men who used either gas metal arc welding (GMAW) (n = 24) or tungsten inert gas welding (TIG) (n = 19) as their major technique. Cr and Ni were determined in pre- and post-shift urine samples. Concentrations below the limit of quantification (LOQ) were multiply imputed. Spearman correlation coefficients (rs) were calculated with 95% confidence intervals (CIs) to explore associations between the exposure variables, and regression models were applied to estimate the effect of the parent metal on the urinary concentration. Results Regarding the respirable Cr(VI), 62% of the measurements were below the LOQ, the 75th percentile was 0.50 µg m-3, and 8 out of 50 (16%) welders exceeded 1 µg m-3. The highest shift concentration that occurred as a result of shielded metal arc welding (SMAW) was 180 µg m-3. The Cr(VI) content in total Cr ranged from 4 to 82% (median 20%), although the concentration correlated with total Cr (rs 0.55, 95% CI 0.46; 0.64). The correlation between Cr(VI) and Ni was weaker (rs 0.42, 95% CI 0.34; 0.51) than that between total Cr and Ni in welding fumes (rs 0.83, 95% CI 0.74; 0.92). Both Cr(VI) and total Cr influenced the urinary Cr concentrations in post-shift samples (P = 0.0008 and P ≤ 0.0001, respectively). The airborne shift exposure was a weaker determinant than the Cr content in pre-shift urine samples, which strongly correlated with post-shift urinary Cr (rs 0.78, 95% CI 0.69; 0.87). Conclusions The Cr(VI) content in total Cr varied considerably in welding fumes. The majority of welders using GMAW or TIG presented with shift concentrations of respirable Cr(VI) below 1 µg m-3. However, very high Cr(VI) concentrations may occur, for example in SMAW. The urinary concentration of total Cr, cannot be used to precisely determine the shift concentration of respirable Cr(VI) in welders.
- Published
- 2017
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