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1. Cerebral Venous Thrombosis after SARS-CoV-2 Infection and Pfizer-BioNTech Vaccination against COVID-19

Author

Martina Nicolardi, Daniele Urso, Silvia Luceri, Giancarlo Logroscino, and Roberto De Blasi

Subjects
cerebral venous thrombosis, COVID-19, vaccination, Susceptibility-Weighted Images, Medicine (General), R5-920
Abstract

In the last 3 years, COVID-19 pandemic has produced great impacts on global population in terms of health and social costs. Pneumonia represents only one of several pathologies associated to COVID-19 disease. Among these, the cerebral venous thrombosis (CVT), constitutes an important cause of stroke. Here, we report a case of CVT diagnosed approximately 2 weeks after first dose of Pfizer-BioNTech vaccination, in a patient affected by COVID-19 few months earlier. He presented with headache and severe asthenia. The laboratory tests put in evidence thrombocytopenia and D-dimer elevation. A brain magnetic resonance imaging (MRI) and a computed tomography (CT) demonstrated hemorrhagic and ischemic phenomena on the right ventral thalamic nuclei, left thalamus, hippocampal and parahippocampal regions and the splenium of the corpus callosum. The study revealed a poorly opacified vein of Galeno and straight sinus. Heparin administration improved his clinical status; platelets values also arose over time.

Published
2022
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2. Streak artefacts in Computed Tomography Urography: Comparative evaluation between two different iodinated contrast media

Author

Angela Sardaro, Rocco Umberto Accogli, Martina Nicolardi, Arnaldo Scardapane, Amato Antonio Stabile Ianora, Pasquale Pedote, and Monica Cozzolino

Subjects
Adult, Urinary system, Iomeprol, Streak, Contrast Media, Computed tomography, Urine, chemistry.chemical_compound, Triiodobenzoic Acids, medicine, Humans, Radiology, Nuclear Medicine and imaging, Retrospective Studies, medicine.diagnostic_test, business.industry, Urography, Iodixanol, Iopamidol, medicine.anatomical_structure, Oncology, chemistry, business, Nuclear medicine, Artifacts, Tomography, X-Ray Computed, Renal pelvis, Pyelogram, medicine.drug, Iodine
Abstract

INTRODUCTION The objective of this study was to compare the frequency and entity, in computed tomography (CT) urography, of streak artefacts on the urinary tract generated by two contrast agents with a different iodine concentration and osmolarity. METHODS Computed tomography scans including an excretory renal phase, performed on adult subjects in the period May-July 2020, were retrospectively evaluated in consensus by three expert radiologists, to detect any streak artefacts located in the urinary tract. Patients were administered either 1.6 mL/kg of Iodixanol 320 mgI/mL or 1.3 mL/kg of Iomeprol 400 mgI/mL. RESULTS In total, 144 CT scans were analysed, subdivided into two groups administered either Iodixanol (71/144 (49.3%) patients) or Iomeprol (73/144 (50.7%) patients). In 41% cases, no beam hardening artefacts were found; among these, 12/59 (20.3%) patients had received Iodixanol and 47/59 (79.7%) Iomeprol. In the Iodixanol group, the mean contrast density on the renal pelvis was 2565.6 HU and streak artefacts occurred in 59/71 cases (83.1%); in 33/59 (55.9%) cases, the artefacts were marked, and in 26/59 (44.1%) minimal. In the Iomeprol group, the mean contrast density on the renal pelvis was 1666 HU and streak artefacts occurred in 26/73 cases (35.6%); in 7/26 (27%) cases, the artefacts were marked and in 19/26 (73%) minimal. CONCLUSION The study data demonstrate a significant difference in the attenuation values of iodine urine in the excretory system between the Iodixanol and Iomeprol group. Iodixanol induced a higher frequency and burden of artefacts, compared to Iomeprol.

Published
2021

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