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11. Corrigendum to “The Italian guidelines on ultrasound in obstetrics and gynecology: Executive summary of recommendations for practice” [Eur. J. Obstetrics Gynecol. 279 (2022) 176–182]

Author

Aprile, Anna, primary, Calì, Giuseppe, additional, Chianchiano, Nicola, additional, Chiappa, Valentina, additional, Corbella, Paola, additional, D'Addario, Vincenzo, additional, Dall'Asta, Andrea, additional, De Robertis, Valentina, additional, Exacustos, Caterina, additional, Familiari, Alessandra, additional, Fichera, Anna, additional, Formigoni, chiara, additional, Frusca, Tiziana, additional, Ghi, Tullio, additional, Guerriero, Stefano, additional, Iuculano, Ambra, additional, Labate, Francesco, additional, Martinelli, Pasquale, additional, Monni, Giovanni, additional, Morlano, Maddalena, additional, Nonino, Francesco, additional, Olivieri, Claudiana, additional, Paladini, Dario, additional, Peddes, Cristina, additional, Prefumo, Federico, additional, Rizzo, Giuseppe, additional, Rustico, Mariangela, additional, Sarno, Laura, additional, Sciacovelli, Irene, additional, Sciarrone, Andrea, additional, Stampalija, Tamara, additional, Taddei, Fabrizio, additional, Todros, Tullia, additional, Valensise, Herbert, additional, Vergani, Patrizia, additional, Volpe, Nicola, additional, Volpe, Paolo, additional, Votino, Carmela, additional, Bettoncelli, Germano, additional, Bracalente, Gabriella, additional, Collini Ceccatelli, Monica, additional, Costantini, Mariapaola, additional, D'Aloia, Antonino, additional, Ferrazzi, Enrico, additional, Giorlandino, Claudio, additional, Locci, Mariavittoria, additional, Verrotti di Pianella, Carla, additional, Viora, Elsa, additional, Zoia, Riccardo, additional, Bilardo, Katia, additional, and Vicar, Maria, additional

Published
2023
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15. 2 year neurodevelopmental and intermediate perinatal outcomes in infants with very preterm fetal growth restriction (TRUFFLE): a randomised trial

Author

Lees, Christoph C, Marlow, Neil, van Wassenaer-Leemhuis, Aleid, Arabin, Birgit, Bilardo, Caterina M, Brezinka, Christoph, Calvert, Sandra, Derks, Jan B, Diemert, Anke, Duvekot, Johannes J, Ferrazzi, Enrico, Frusca, Tiziana, Ganzevoort, Wessel, Hecher, Kurt, Martinelli, Pasquale, Ostermayer, Eva, Papageorghiou, Aris T, Schlembach, Dietmar, Schneider, K T M, Thilaganathan, Baskaran, Todros, Tullia, Valcamonico, Adriana, Visser, Gerard H A, and Wolf, Hans

Published
2015
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18. Parto pretermine

Author

Maruotti, Giuseppe Maria, Agangi, Annalisa, Mazzarelli, Laura Letizia, Martinelli, Pasquale, Borrelli, Antonio Luciano, Arduini, Domenico, Cardone, Antonio, and Ventruto, Valerio

Published
2008
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19. Maternal and neonatal outcomes in planned versus emergency cesarean delivery for placenta accreta spectrum

Author

Morlando, Maddalena, Schwickert, Alexander, Stefanovic, Vedran, Gziri, Mina M., Pateisky, Petra, Chalubinski, Kinga M., Nonnenmacher, Andreas, Morel, Olivier, Braun, Thorsten, Bertholdt, Charline, Beekhuizen, Heleen J. Van, Collins, Sally L., Calda, Pavel, Chantraine, Fredric, Duvekot, Johannes J., Fox, Karin A., Gronbeck, Lene, Henrich, Wolfgang, Martinelli, Pasquale, Paavonen, Jorma, Petit, Philippe, Rijken, Marcus, Ropacka, Mariola, Tikkanen, Minna, Weichert, Alexander, Weizsäcker, Katharina, International Society For Placenta Accreta Spectrum (IS‐PAS), HUS Gynecology and Obstetrics, Department of Obstetrics and Gynecology, Helsinki University Hospital Area, University of Helsinki, UCL - (SLuc) Service d'obstétrique, UCL - SSS/IREC/SLUC - Pôle St.-Luc, Università degli studi di Napoli Federico II, Università degli studi della Campania 'Luigi Vanvitelli', Freie Universität Berlin, Humboldt-Universität zu Berlin, Cliniques Universitaires Saint-Luc [Bruxelles], Université médicale de Vienne, Autriche, Service d'Obstétrique et de Gynécologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Université de Lorraine (UL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Erasmus University Medical Center [Rotterdam] (Erasmus MC), Nuffield (Nuffield), University of Oxford [Oxford], John Radcliffe Hospital [Oxford University Hospital], Morlando, Maddalena, Schwickert, Alexander, Stefanovic, Vedran, Gziri, Mina M, Pateisky, Petra, Chalubinski, Kinga M, Nonnenmacher, Andrea, Morel, Olivier, Braun, Thorsten, Bertholdt, Charline, Van Beekhuizen, Heleen J, Collins, Sally L, Obstetrics and Gynaecology, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Gynecological Oncology, and Obstetrics & Gynecology

Subjects
Emergency Medical Services, Databases, Factual, Maternal Health, Cohort Studies, maternal morbidity, placenta accreta spectrum, 0302 clinical medicine, Retrospective Studie, Pregnancy, 3123 Gynaecology and paediatrics, 030212 general & internal medicine, gestational age, ComputingMilieux_MISCELLANEOUS, 030219 obstetrics & reproductive medicine, Obstetrics, Pregnancy Outcome, Obstetrics and Gynecology, Gestational age, General Medicine, Pregnancy Complication, 3. Good health, Europe, Gestation, Female, medicine.symptom, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, Human, United State, Adult, medicine.medical_specialty, Referral, Placenta accreta, Gestational Age, Hemorrhage, [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine, Placenta Accreta, 03 medical and health sciences, abnormally invasive placenta, medicine, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Humans, Vaginal bleeding, Infant Health, Risk factor, Retrospective Studies, Antepartum hemorrhage, business.industry, Cesarean Section, neonatal morbidity, medicine.disease, Confidence interval, United States, Pregnancy Complications, Cohort Studie, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Introduction: Placenta accreta spectrum (PAS) is a condition often resulting in severe maternal morbidity. Scheduled delivery by an experienced team has been shown to improve maternal outcomes; however, the benefits must be weighed against the risk of iatrogenic prematurity. The aim of this study is to investigate the rates of emergency delivery seen for antenatally suspected PAS and compare the resulting outcomes in the 15 referral centers of the International Society for PAS (IS-PAS). Material and methods: Fifteen centers provided cases between 2008 and 2019. The women included were divided into two groups according to whether they had a planned or an emergency cesarean delivery. Delivery was defined as “planned” when performed at a time and date to suit the team. All the remaining cases were classified as “emergency”. Maternal characteristics and neonatal outcomes were compared between the two groups according to gestation at delivery. Results: In all, 356 women were included. Of these, 239 (67%) underwent a planned delivery and 117 (33%) an emergency delivery. Vaginal bleeding was the indication for emergency delivery in 41 of the 117 women (41%). There were no significant differences in terms of blood loss, transfusion rates or major maternal morbidity between planned and emergency deliveries. However, the rate of maternal intensive therapy unit admission was increased with emergency delivery (45% vs 33%, P =.02). Antepartum hemorrhage was the only independent predictor of emergency delivery (aOR: 4.3, 95% confidence interval 2.4-7.7). Emergency delivery due to vaginal bleeding was more frequent with false-positive cases (antenatally suspected but not confirmed as PAS at delivery) and the milder grades of PAS (accreta/increta). The rate of infants experiencing any major neonatal morbidity was 25% at 34+1 to 36+0 weeks and 19% at >36+0 weeks. Conclusions: Emergency delivery in centers of excellence did not increase blood loss, transfusion rates or maternal morbidity. The single greatest risk factor for emergency delivery was antenatal hemorrhage. When adequate expertise and resources are available, to defer delivery in women with no significant antenatal bleeding and no risk factors for pre-term birth until >36+0 weeks can be considered to improve fetal outcomes. Further studies are needed to investigate this fully.

Published
2021

20. Association of peripartum management and high maternal blood loss at cesarean delivery for placenta accreta spectrum (PAS)

Author

Schwickert, Alexander, Beekhuizen, Heleen J. Van, Bertholdt, Charline, Fox, Karin A., Kayem, Gilles, Morel, Olivier, Rijken, Marcus J., Stefanovic, Vedran, Strindfors, Gita, Weichert, Alexander, Weizsaecker, Katharina, Braun, Thorsten, Calda, Pavel, Chalubinski, Kinga M., Chantraine, Frederic, Collins, Sally, Duvekot, Johannes J., Gronbeck, Lene, Henrich, Wolfgang, Martinelli, Pasquale, Mhallem Gziri, Mina, Morlando, Maddalena, Nonnenmacher, Andreas, Paavonen, Jorma, Pateisky, Petra, Petit, Philippe, Ropacka, Mariola, Tikkanen, Minna, International Society For Placenta Accreta Spectrum (IS‐PAS), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Erasmus University Medical Center [Rotterdam] (Erasmus MC), Service d'Obstétrique et de Gynécologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Baylor College of Medecine, Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), University Medical Center [Utrecht], University of Helsinki, Stockholm South Hospital, Medicine Charles University and General Faculty Hospital in Prague, Medizinische Universität Wien = Medical University of Vienna, Centre Hospitalier Universitaire de Liège (CHU-Liège), John Radcliffe Hospital [Oxford University Hospital], Rigshospitalet [Copenhagen], Copenhagen University Hospital, University of Naples Federico II, Cliniques Universitaires Saint-Luc [Bruxelles], University of the Study of Campania Luigi Vanvitelli, Helsinki University Hospital, Poznan University of Medical Sciences [Poland] (PUMS), Obstetrics and Gynaecology, BIRKER, Juliette, Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, University of Naples Federico II = Università degli studi di Napoli Federico II, Department of Obstetrics and Gynecology, University Management, HUS Gynecology and Obstetrics, Gynecological Oncology, and Obstetrics & Gynecology

Subjects
Databases, Factual, medicine.medical_treatment, [INFO.INFO-IM] Computer Science [cs]/Medical Imaging, Blood Loss, Surgical, Uterotonic, high&#8208, Conservative Treatment, Cohort Studies, 0302 clinical medicine, 3123 Gynaecology and paediatrics, Pregnancy, 030212 general & internal medicine, Embolization, hysterectomy, ComputingMilieux_MISCELLANEOUS, 030219 obstetrics & reproductive medicine, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Obstetrics, Obstetrics and Gynecology, General Medicine, 3. Good health, Europe, medicine.anatomical_structure, postpartum hemorrhage, Female, cesarean, Tranexamic acid, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, medicine.drug, Adult, medicine.medical_specialty, placenta, Placenta accreta, Placenta Percreta, high-risk pregnancy, Placenta Accreta, [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine, [SDV.IB.MN] Life Sciences [q-bio]/Bioengineering/Nuclear medicine, 03 medical and health sciences, abnormally invasive placenta, Placenta, risk pregnancy, medicine, Peripartum Period, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Humans, Patient Care Team, Hysterectomy, business.industry, Cesarean Section, uterine scar, medicine.disease, Arterial occlusion, United States, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

INTRODUCTION: Placenta accreta spectrum (PAS) carries a high burden of adverse maternal outcomes, especially significant blood loss, which can be life-threatening. Different management strategies have been proposed but the association of clinical risk factors and surgical management options during cesarean delivery with high blood loss is not clear. MATERIAL AND METHODS: In this international multicenter study, 338 women with PAS undergoing cesarean delivery were included. Fourteen European and one non-European center (USA) provided cases treated retrospectively between 2008 and 2014 and prospectively from 2014 to 2019. Peripartum blood loss was estimated visually and/or by weighing and measuring of volume. Participants were grouped based on blood loss above or below the 75th percentile (>3500 ml) and the 90th percentile (>5500 ml). RESULTS: Placenta percreta was found in 58% of cases. Median blood loss was 2000 ml (range: 150-20 000 ml). Unplanned hysterectomy was associated with an increased risk of blood loss >3500 ml when compared with planned hysterectomy (adjusted OR [aOR] 3.7 [1.5-9.4], p = 0.01). Focal resection was associated with blood loss comparable to that of planned hysterectomy (crude OR 0.7 [0.2-2.1], p = 0.49). Blood loss >3500 ml was less common in patients undergoing successful conservative management (placenta left in situ, aOR 0.1 [0.0-0.6], p = 0.02) but was more common in patients who required delayed hysterectomy (aOR 6.5 [1.7-24.4], p = 0.001). Arterial occlusion methods (uterine or iliac artery ligation, embolization or intravascular balloons), application of uterotonic medication or tranexamic acid showed no significant effect on blood loss >3500 ml. Patients delivered by surgeons without experience in PAS were more likely to experience blood loss >3500 ml (aOR 3.0 [1.4-6.4], p = 0.01). CONCLUSIONS: In pregnant women with PAS, the likelihood of blood loss >3500 ml was reduced in planned vs unplanned cesarean delivery, and when the surgery was performed by a specialist experienced in the management of PAS. This reinforces the necessity of delivery by an expert team. Conservative management was also associated with less blood loss, but only if successful. Therefore, careful patient selection is of great importance. Our study showed no consistent benefit of other adjunct measures such as arterial occlusion techniques, uterotonics or tranexamic acid.

Published
2021

22. Reply

Author

Saccone, Gabriele, Berghella, Vincenzo, Maruotti, Giuseppe Maria, and Martinelli, Pasquale

Published
2017
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30. Antiphospholipid antibody profile based obstetric outcomes of primary antiphospholipid syndrome: the PREGNANTS study

Author

Saccone, Gabriele, Berghella, Vincenzo, Maruotti, Giuseppe Maria, Ghi, Tullio, Rizzo, Giuseppe, Simonazzi, Giuliana, Rizzo, Nicola, Facchinetti, Fabio, Dall’Asta, Andrea, Visentin, Silvia, Sarno, Laura, Xodo, Serena, Bernabini, Dalila, Monari, Francesca, Roman, Amanda, Eke, Ahizechukwu Chigoziem, Hoxha, Ariela, Ruffatti, Amelia, Schuit, Ewoud, and Martinelli, Pasquale

Published
2017
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35. Phase-rectified signal averaging method to predict perinatal outcome in infants with very preterm fetal growth restriction- a secondary analysis of TRUFFLE-trial

Author

Bilardo, Caterina M., Brezinka, Christoph, Diemert, Anke, Derks, Jan B., Schlembach, Dietmar, Todros, Tullia, Valcamonico, Adriana, Marlow, Neil, van Wassenaer-Leemhuis, Aleid, Lobmaier, Silvia M., Mensing van Charante, Nico, Ferrazzi, Enrico, Giussani, Dino A., Shaw, Caroline J., Müller, Alexander, Ortiz, Javier U., Ostermayer, Eva, Haller, Bernhard, Prefumo, Federico, Frusca, Tiziana, Hecher, Kurt, Arabin, Birgit, Thilaganathan, Baskaran, Papageorghiou, Aris T., Bhide, Amarnath, Martinelli, Pasquale, Duvekot, Johannes J., van Eyck, Jim, Visser, Gerard H.A., Schmidt, Georg, Ganzevoort, Wessel, Lees, Christoph C., and Schneider, Karl T.M.

Published
2016
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36. A multicenter observational survey of management strategies in 442 pregnancies with suspected placenta accreta spectrum

Author

Beekhuizen, Heleen, Stefanovic, Vedran, Schwickert, Alexander, Henrich, Wolfgang, Fox, Karin, Mhallem Gziri, Mina, Sentilhes, Loïc, Gronbeck, Lene, Chantraine, Frederic, Morel, Oliver, Bertholdt, Charline, Braun, Thorsten, Rijken, Marcus, Duvekot, Johannes, Calda, Pavel, Chalubinski, Kinga, Collins, Sally, Martinelli, Pasquale, Morlando, Maddalena, Nonnenmacher, Andreas, Paavonen, Jorma, Pateisky, Petra, PETIT, Philippe, Ropacka, Mariola, Tikkanen, Minna, Tutschek, Boris, Weichert, Alexander, Weizsäcker, Katharina von, Erasmus University Medical Center [Rotterdam] (Erasmus MC), University of Helsinki, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Baylor College of Medecine, Cliniques Universitaires Saint-Luc [Bruxelles], CHU Bordeaux [Bordeaux], University of Copenhagen = Københavns Universitet (KU), Centre Hospitalier Universitaire de Liège (CHU-Liège), Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Service d'Obstétrique et de Gynécologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), University Medical Center [Utrecht], UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - (SLuc) Service d'obstétrique, Obstetrics and Gynaecology, HUS Gynecology and Obstetrics, Department of Obstetrics and Gynecology, Helsinki University Hospital Area, Gynecological Oncology, and Obstetrics & Gynecology

Subjects
medicine.medical_specialty, Placenta accreta, medicine.medical_treatment, Obstetric Surgical Procedures, Prenatal diagnosis, Hemorrhage, Placenta Accreta, [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine, Conservative Treatment, Hysterectomy, 03 medical and health sciences, placenta accreta spectrum, 0302 clinical medicine, 3123 Gynaecology and paediatrics, Pregnancy, Placenta, Original Research Articles, medicine, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Humans, 030212 general & internal medicine, Original Research Article, ComputingMilieux_MISCELLANEOUS, Patient Care Team, Laparotomy, 030219 obstetrics & reproductive medicine, cesarean section, business.industry, Obstetrics, Vaginal delivery, Obstetrics and Gynecology, Gestational age, Abortion, Induced, General Medicine, medicine.disease, 3. Good health, Placenta previa, abnormal invasive placenta, medicine.anatomical_structure, postpartum hemorrhage, Female, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

INTRODUCTION: Management options for women with placenta accreta spectrum (PAS) comprise termination of pregnancy before the viable gestational age, leaving the placenta in situ for subsequent reabsorption of the placenta or delayed hysterectomy, manual removal of placenta after vaginal delivery or during cesarean section, focal resection of the affected uterine wall, and peripartum hysterectomy. The aim of this observational study was to describe actual clinical management and outcomes in PAS in a large international cohort. MATERIAL AND METHODS: Data from women in 15 referral centers of the International Society of PAS (IS-PAS) were analyzed and correlated with the clinical classification of the IS-PAS: From Grade 1 (no PAS) to Grade 6 (invasion into pelvic organs other than the bladder). PAS was usually diagnosed antenatally and the operators performing ultrasound rated the likelihood of PAS on a Likert scale of 1 to 10. RESULTS: In total, 442 women were registered in the database. No maternal deaths occurred. Mean blood loss was 2600 mL (range 150-20 000 mL). Placenta previa was present in 375 (84.8%) women and there was a history of a previous cesarean in 329 (74.4%) women. The PAS likelihood score was strongly correlated with the PAS grade (P

Published
2021

39. Inpatientvsoutpatient management and timing of delivery of uncomplicated monochorionic monoamniotic twin pregnancy: the MONOMONO study

Author

Saccone, Gabriele, Berghella, Vincenzo, Locci, Mariavittoria, Ghi, Tullio, Frusca, Tiziana, Lanna, Mariano, Faiola, Stefano, Fichera, Anna, Prefumo, Federico, Rizzo, Giuseppe, Bosi, Costanza, Arduino, Bruno, D'Alessandro, Pietro, Borgo, Maria, Arduino, Silvana, Cantanna, Elisabetta, Simonazzi, Giuliana, Rizzo, Nicola, Francesca, Giorgetta, Seravalli, Viola, Miller, Jena L., Magro-Malosso, Elena Rita, Di Tommaso, Mariarosaria, Dall'Asta, Andrea, Galli, Letizia, Volpe, Nicola, Visentin, Silvia, Cosmi, Erich, Sarno, Laura, Caissutti, Claudia, Driul, Lorenza, Anastasio, Hannah, Di Mascio, Daniele, Panici, Pierluigi Benedetti, Vena, Flaminia, Brunelli, Roberto, Ciardulli, Andrea, D'Antonio, Francesco, Schoen, Corina, Suhag, Anju, Gambacorti-Passerini, Zita Maria, Baz, Maria Angeles Anaya, Magoga, Giulia, Busato, Enrico, Filippi, Elisa, Suárez, María José Rodriguez, Alderete, Francisco Gamez, Ortuno, Paula Alonso, Vitagliano, Amerigo, Mollo, Antonio, Raffone, Antonio, Vendola, Marianne, Navaneethan, Preethi, Wimalasundera, Ruwan, Napolitano, Raffaele, Aquino, Carmen Imma, D'Agostino, Serena, Gallo, Cinzia, Maruotti, Giuseppe Maria, Flacco, Maria Elena, Baschat, Ahmet A., Venturella, Roberta, Guida, Maurizio, Martinelli, Pasquale, Zullo, Fulvio, Saccone G, Berghella V, Locci M, Ghi T, Frusca T, Lanna M, Faiola S, Fichera A, Prefumo F, Rizzo G, Bosi C, Arduino B, D'Alessandro P, Borgo M, Arduino S, Cantanna E, Simonazzi G, Rizzo N, Francesca G, Seravalli V, Miller JL, Magro-Malosso ER, Di Tommaso M, Dall'Asta A, Galli L, Volpe N, Visentin S, Cosmi E, Sarno L, Caissutti C, Driul L, Anastasio H, Di Mascio D, Panici PB, Vena F, Brunelli R, Ciardulli A, D'Antonio F, Schoen C, Suhag A, Gambacorti-Passerini ZM, Baz MAA, Magoga G, Busato E, Filippi E, Suárez MJR, Alderete FG, Ortuno PA, Vitagliano A, Mollo A, Raffone A, Vendola M, Navaneethan P, Wimalasundera R, Napolitano R, Aquino CI, D'Agostino S, Gallo C, Maruotti GM, Flacco ME, Baschat AA, Venturella R, Guida M, Martinelli P, Zullo F., Saccone, G., Berghella, V., Locci, M., Ghi, T., Frusca, T., Lanna, M., Faiola, S., Fichera, A., Prefumo, F., Rizzo, G., Bosi, C., Arduino, B., D'Alessandro, P., Borgo, M., Arduino, S., Cantanna, E., Simonazzi, G., Rizzo, N., Francesca, G., Seravalli, V., Miller, J. L., Magro-Malosso, E. R., Di Tommaso, M., Dall'Asta, A., Galli, L., Volpe, N., Visentin, S., Cosmi, E., Sarno, L., Caissutti, C., Driul, L., Anastasio, H., Di Mascio, D., Panici, P. B., Vena, F., Brunelli, R., Ciardulli, A., D'Antonio, F., Schoen, C., Suhag, A., Gambacorti-Passerini, Z. M., Baz, M. A. A., Magoga, G., Busato, E., Filippi, E., Suarez, M. J. R., Alderete, F. G., Ortuno, P. A., Vitagliano, A., Mollo, A., Raffone, A., Vendola, M., Navaneethan, P., Wimalasundera, R., Napolitano, R., Aquino, C. I., D'Agostino, S., Gallo, C., Maruotti, G. M., Flacco, M. E., Baschat, A. A., Venturella, R., Guida, M., Martinelli, P., and Zullo, F.

Subjects
Cardiotocography, chorionicity, Twins, Cesarean delivery, cord accident, cord entanglement, healthcare, monochorionic, multiple gestation, perinatal death, respiratory distress syndrome, twin pregnancy, Radiological and Ultrasound Technology, Reproductive Medicine, Radiology, Nuclear Medicine and Imaging, Obstetrics and Gynecology, 0302 clinical medicine, Pregnancy, Nuclear Medicine and Imaging, Outpatients, Health care, Prenatal, Medicine, 030212 general & internal medicine, Twin Pregnancy, Monochorionic monoamniotic twin pregnancy, Ultrasonography, Cord entanglement, 030219 obstetrics & reproductive medicine, Obstetrics, Adult, Female, Fetal Death, Humans, Infant, Newborn, Inpatients, Length of Stay, Live Birth, Perinatal Death, Pregnancy, Twin, Prenatal Care, Retrospective Studies, Statistics, Nonparametric, Twins, Monozygotic, Ultrasonography, Prenatal, Perinatal Mortality, Statistics, General Medicine, cesarean delivery, health care, Radiology, medicine.medical_specialty, Socio-culturale, Monozygotic, Multiple Gestation, 03 medical and health sciences, Nonparametric, Radiology, Nuclear Medicine and imaging, business.industry, Infant, Twin, Newborn, Settore MED/40 - Ginecologia e Ostetricia, business, Outpatient management
Abstract

OBJECTIVES: Monoamniotic twin pregnancies are at increased risk of perinatal complications, primarily owing to the risk of cord entanglement. There is no recommendation on whether such pregnancies should be managed in hospital or can be safely managed in an outpatient setting, and the timing of planned delivery is also a subject of debate. The aim of this study was to compare the perinatal outcomes of inpatient vs outpatient fetal surveillance approaches employed among 22 participating study centers, and to calculate the fetal and neonatal death rates according to gestational age, in non-anomalous monoamniotic twins from 26 weeks' gestation. METHODS: The MONOMONO study was a multinational cohort study of consecutive women with monochorionic monoamniotic twin pregnancies, who were referred to 22 university hospitals in Italy, the USA, the UK and Spain, from January 2010 to January 2017. Only non-anomalous uncomplicated monoamniotic twin pregnancies with two live fetuses at 26 + 0 weeks' gestation were included in the study. In 10 of the centers, monoamniotic twins were managed routinely as inpatients, whereas in the other 12 centers they were managed routinely as outpatients. The primary outcome was intrauterine fetal death. We also planned to assess fetal and neonatal death rates according to gestational age per 1-week interval. Outcomes are presented as odds ratio (OR) with 95% CIs. The main outcome was analyzed using both standard logistic regression analysis, in which each fetus was treated as an independent unit, and a generalized mixed-model approach, with each twin pair treated as a cluster unit, considering that the outcome for a twin is not independent of that of its cotwin. RESULTS: 195 consecutive pregnant women with a non-anomalous uncomplicated monoamniotic twin gestation (390 fetuses) were included. Of these, 75 (38.5%) were managed as inpatients and 120 (61.5%) as outpatients. The overall perinatal loss rate was 10.8% (42/390) with a peak fetal death rate of 4.3% (15/348) occurring at 29 weeks' gestation. There was no significant difference in mean gestational age at delivery (31 weeks), birth weight (∼1.6 kg), or emergency delivery rate between the inpatient and outpatient surveillance groups. Based on generalized mixed-model analysis, there was no statistically significant difference in fetal death rates between inpatient management commencing from around 26 weeks compared with outpatient surveillance protocols from 30 weeks (3.3% vs 10.8%; adjusted OR 0.21 (95% CI, 0.04-1.17)). Maternal length of stay in the hospital was 42.1 days in the inpatient group, and 7.4 days in the outpatient group (mean difference 34.70 days (95% CI, 31.36-38.04 days). From 32 + 0 to 36 + 6 weeks, no fetal or neonatal death in either group was recorded. 46 fetuses were delivered after 34 + 0 weeks, and none of them died in utero or within the first 28 days postpartum. CONCLUSION: In uncomplicated monoamniotic twins, inpatient surveillance is associated with similar fetal mortality as outpatient management. After 31 + 6 weeks, and up to 36 + 6 weeks, there were no intrauterine fetal deaths or neonatal deaths. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd.

Published
2018

40. Developing a database for multicenter evaluation of placenta accreta spectrum

Author

Braun, Thorsten, Beekhuizen, Heleen J. Van, Morlando, Maddalena, Morel, Olivier, Stefanovic, Vedran, Al Naimi, Ammar, Bertholdt, Charline, Calda, Pavel, Chalubinski, Kinga M, Pateisky, Petra, Chantraine, Fredric, Petit, Philippe, Collins, Sally, Duvekot, Johannes J, Fox, Karin, Gronbeck, Lene, Henrich, Wolfgang, Nonnenmacher, Andreas, Schwickert, Alexander, Martinelli, Pasquale, Mhallem Gziri, Mina, Paavonen, Jorma, Tikkanen, Minna, Rijken, Marcus, Ropacka, Mariola, Strindfors, Gita, Weichert, Alexander, Weizsäcker, Katharina Von, International Society For Placenta Accreta Spectrum (IS‐PAS), Freie Universität Berlin, Humboldt-Universität zu Berlin, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Università degli studi della Campania 'Luigi Vanvitelli', Service d'Obstétrique et de Gynécologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), University of Helsinki, First Faculty of Medicine Charles University [Prague], Medizinische Universität Wien = Medical University of Vienna, Centre Hospitalier Universitaire de Liège (CHU-Liège), University of Oxford [Oxford], John Radcliffe Hospital [Oxford University Hospital], Baylor College of Medicine (BCM), Baylor University, Copenhagen University Hospital, Università degli studi di Napoli Federico II, Cliniques Universitaires Saint-Luc [Bruxelles], University Medical Center [Utrecht], Poznan University of Medical Sciences [Poland] (PUMS), Obstetrics and Gynaecology, Gynecological Oncology, Obstetrics & Gynecology, Université de Lorraine (UL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Braun, Thorsten, van Beekhuizen, Heleen J, Morlando, Maddalena, Morel, Olivier, and Stefanovic, Vedran

Subjects
Societies, Scientific, Databases, Factual, Placenta accreta, online database, [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine, Placenta Accreta, computer.software_genre, Imaging data, 03 medical and health sciences, placenta accreta spectrum, 0302 clinical medicine, Pregnancy, abnormally invasive placenta, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Medicine, Humans, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, 030219 obstetrics & reproductive medicine, Data collection, case reporting form, Database, business.industry, Online database, Obstetrics and Gynecology, General Medicine, medicine.disease, Current analysis, 3. Good health, Female, business, computer, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, Human
Abstract

Studies of rare, but complex clinical conditions require multicenter cooperation. The International Society for Placenta accreta spectrum (IS-PAS) have established a secure web-based database to analyze pregnancies complicated by PAS. By repeated in-person meetings of the IS-PAS, a core dataset was established. Then, a custom-made, secure online database, capable of receiving strictly anonymized patient-related textual and imaging data and allowing statistical queries was designed, tested, amended and implemented. Between 2008 and 2019, 14 IS-PAS centers across Europe and one center in the USA contributed data for all their PAS cases, containing pregnancy data for a total of 442 pregnant women. Data were analyzed by a designated data analysis sub-group of the IS-PAS. Center characteristics are presented. Based on experiences with previous versions, our new online database now allows an all-encompassing data collection. It has shown its usefulness in the current analysis project.

Published
2021
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43. Antiretroviral treatment in pregnancy: a six-year perspective on recent trends in prescription patterns, viral load suppression, and pregnancy outcomes

Author

Baroncelli, Silvia, Tamburrini, Enrica, Ravizza, Marina, Dalzero, Serena, Tibaldi, Cecilia, Ferrazzi, Enrico, Anzidei, Gianfranco, Fiscon, Marta, Alberico, Salvatore, Martinelli, Pasquale, Placido, Giuseppina, Guaraldi, Giovanni, Pinnetti, Carmela, and Floridia, Marco

Subjects
Pregnancy -- Drug therapy, Pregnancy -- Patient outcomes, Antiviral agents -- Usage, Antiviral agents -- Health aspects, Antiviral agents -- Forecasts and trends, HIV (Viruses) -- Drug therapy, HIV (Viruses) -- Demographic aspects, HIV (Viruses) -- Patient outcomes, Market trend/market analysis, Health
Abstract

The aim of the study was to describe the recent trends in antiretroviral treatment in late pregnancy and the sociodemographic changes among pregnant women with HIV over the last 6 years. Data from the National Program on Surveillance on Antiretroviral Treatment in Pregnancy in Italy were grouped per calendar year, and changes in antiretroviral treatment, population characteristics, maternal immunovirologic status and newborn clinical parameters were analyzed. A total of 981 HIV-infected mothers who delivered between 2002 and 2008 were evaluated. The proportion of women receiving at least three antiretroviral drugs at delivery increased significantly from 63.0% in 2002 to 95.5% in 2007-2008, paralleled by a similar upward trend in the proportion of women who achieved complete viral suppression at third trimester (from 37.3 in 2002 to 80.9 in 2007-2008; p < 0.001). The co-formulation of zidovudine plus lamivudine remained the most common nucleoside backbone in pregnancy, even if a significant increase in the use of tenofovir plus emtricitabine was observed in more recent years. Starting from 2003, nevirapine prescription declined, paralleled by a significant rise in the use of protease inhibitors (PI), which were present in more than 60% of regimens administered in 2007-2008. Nelfinavir was progressively replaced by ritonavir-boosted PIs, mainly lopinavir. No significant changes in preterm delivery, Apgar score, birth weight, and birth defects were observed during the study period, and the rate of HIV transmission remained below 2%. These data demonstrate a significant evolution in the treatment of HIV in pregnancy. Constant improvements in the rates of HIV suppression were observed, probably driven by the adoption of stronger and more effective regimens and by the increasing options available for combination treatment.

Published
2009

44. Noninvasive screening for congenital heart defects using a serum metabolomics approach

Author

Troisi, Jacopo, primary, Cavallo, Pierpaolo, additional, Richards, Sean, additional, Symes, Steven, additional, Colucci, Angelo, additional, Sarno, Laura, additional, Landolfi, Annamaria, additional, Scala, Giovanni, additional, Adair, David, additional, Ciccone, Carla, additional, Maruotti, Giuseppe M., additional, Martinelli, Pasquale, additional, and Guida, Maurizio, additional

Published
2021
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47. Comparative analysis of 2-year outcomes in GRIT and TRUFFLE trials

Author

Ganzevoort, W., Thornton, J. G., Marlow, N., Thilaganathan, B., Arabin, B., Prefumo, F., Lees, C., Wolf, H., Van Bulck, B, Kalakoutis, G M, Sak, P, Schneider, K T M, Karpathios, S E, Major, T, Todros, T, Arduini, D, Flumini, C, Tenore, A C, Roncaglia, N, Frusca, T, Ferretti, G, Weinans, M J N, Roosmalen, J, Slikke, J W, Geijn, H, Pernet, P J M, Wolf, H, Stigter, R H, Wilczynski, J, Vasco, E, Abdullah, M, Novak‐Antolic, Z, Danielian, P, Jenkinson, S D, Welch, C R, Griffin, C, Gee, H, Tuffnell, D, Cresswell, J, Tariq, T, Sengupta, B, Tydeman, G, Churchill, D, Bewley, S, Fusi, L, Lindow, S W, Johal, W, Fairlie, F M, Neales, K, Mason, G, Scudamore, I, Konje, J, Walkinshaw, S A, Griffiths, M, Dawson, A, Mires, G, Johanson, R, Fraser, R B, Ibbs, P Hendy, Steel, S A, Ramsay, M, Robins, J B, Heard, M J, Tonge, H M, Manyonda, I T, Walker, J, Maresh, M, Yoong, A, Soothill, P, Cameron, H, Byrne, D, Beattie, B, Bober, S, Van Damme, M, Kyriakides, S, Pokorna, P, Zimmerman, A, Tsitsikas, H, Mani, E, Bosisio, P, Mastritta, E, Nicocia, M, Fabris, C, Eken, P, De Vries, L, Kubicka, Z, Ramalho, R, Rashid, M, Cerar‐Kornhauser, L, Thomas, S, Elliman, A, Sim, T, Swaminathan, S, Walker, L, McCormick, D, Sibanda, Z, Hughes, J, Kilding, J, O'Hara, A, Harpin, V, Porter, N, Pandey, S, Murtagh, K, Burton, K, MacGregor, R, Stewart, B, Klenke, H, Hallam, P, Kai, N, Graham, M, Harrison, A, Saharia, E, McGhee, T, Rowsell, P, Howie, P, Parmar, Max, Field, D, Grant, A, Steer, P, Breart, G, Levene, M, Torgeson, D, Kitzinger, S, Marlowe, N, Wolke, Dieter, Johnson, A, Arabin, Birgit, Bilardo, Caterina M, Brezinka, Christoph, Cornette, Jerome M J, Derks, Jan B, Diemert, Anke, Duvekot, Johannes J, Ferrazzi, Enrico, Fratelli, Nicola, Frusca, Tiziana, Ganzevoort, Wessel, Hecher, Kurt, Leemhuis, Aleid, Lees, Christoph C, Lobmaier, Silvia, Marlow, Neil, Martinelli, Pasquale, Maso, Gianpaolo, Missfelder‐Lobos, Hannah, Napolitano, Raffaele, Ostermayer, Eva, Papageorghiou, Aris T, Prefumo, Federico, Schlembach, Dietmar, Thilaganathan, Baskaran, Todros, Tullia, Valcamonico, Adriana, Visser, Gerard H A, Wolf, Hans, Kingdom, John, Marsal, Karel, Thornton, Jim, Valensise, Herbert, Athena Institute, APH - Global Health, APH - Quality of Care, Obstetrics and gynaecology, Papageorghiou, AT, Obstetrics and Gynaecology, AR&D - Amsterdam Reproduction & Development, and APH - Digital Health

Subjects
short‐term variation, Technology, FLOW, INFANTS, cardiotocography, ductus venosus, fetal growth restriction, monitoring, short-term variation, Umbilical Arteries, Cohort Studies, 0302 clinical medicine, Obstetrics and gynaecology, Pregnancy, GROWTH RESTRICTION, Cardiotocography, 030212 general & internal medicine, Randomized Controlled Trials as Topic, Fetal Growth Retardation, 030219 obstetrics & reproductive medicine, Radiological and Ultrasound Technology, medicine.diagnostic_test, Obstetrics, Radiology, Nuclear Medicine & Medical Imaging, short term variation, Pregnancy Outcome, Obstetrics & Gynecology, Obstetrics and Gynecology, Gestational age, General Medicine, Original Papers, TRUFFLE Study Group, Settore MED/40, Pulsatile Flow, Gestation, Female, Life Sciences & Biomedicine, INTERVENTION, Blood Flow Velocity, Ductus venosus, Cohort study, medicine.medical_specialty, Birth weight, FETAL HEART-RATE, Ultrasonography, Prenatal, 03 medical and health sciences, SDG 3 - Good Health and Well-being, FETUSES, medicine, Humans, Radiology, Nuclear Medicine and imaging, Obstetrics & Reproductive Medicine, Fetal Death, GRIT Study Group, Original Paper, Fetus, Science & Technology, business.industry, Infant, Newborn, Acoustics, Reproductive Medicine, 1114 Paediatrics and Reproductive Medicine, business
Abstract

Objective To explore the effect on perinatal outcome of different fetal monitoring strategies for early‐onset fetal growth restriction (FGR). Methods This was a cohort analysis of individual participant data from two European multicenter trials of fetal monitoring methods for FGR: the Growth Restriction Intervention Study (GRIT) and the Trial of Umbilical and Fetal Flow in Europe (TRUFFLE). All women from GRIT (n = 238) and TRUFFLE (n = 503) who were randomized between 26 and 32 weeks' gestation were included. The women were grouped according to intervention and monitoring method: immediate delivery (GRIT) or delayed delivery with monitoring by conventional cardiotocography (CTG) (GRIT), computerized CTG (cCTG) only (GRIT and TRUFFLE) or cCTG and ductus venosus (DV) Doppler (TRUFFLE). The primary outcome was survival without neurodevelopmental impairment at 2 years of age. Results Gestational age at delivery and birth weight were similar in both studies. Fetal death rate was similar between the GRIT and TRUFFLE groups, but neonatal and late death were more frequent in GRIT (18% vs 6%; P, This article's abstract has been translated into Spanish and Chinese. Follow the links from the http://onlinelibrary.wiley.com/doi/10.1002/uog.20354/abstract to view the translations. This article has been selected for Journal Club. Click https://www.isuog.org/resource/uog-journal-club-January-2020.html to view slides and discussion points.

Published
2020

50. Antibiotic prophylaxis before amniocentesis

Author

Hobbins, John C., Pilu, Gianluigi, Abuhumad, Alfred, Alfirevic, Zarko, Bahado-Singh, Ray O., Benacerraf, Beryl R., Berkowitz7, Richard L., Cetin, Irene, Copel, Joshua A., Eik-Nes, Sturla, Frusca, Tiziana, Galan, Henry L., Guaschino, Secondo, Mahoney, Maurice J., Marsal, Karel, Malinger, Gustavo, Marconi, Anna Maria, Martinelli, Pasquale, Moore, Thomas R., Papageorghiou, Aris T., Platt, Lawrence D., Rizzo, Nicola, Tabor, Ann, Thilaganathan, Baskaran, Timor-Tritsch, Ilan E., Todros, Tullia, and Yagel, Simcha

Published
2011
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