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This study aims to provide a complex overview of the sustainability aspect of green mortgage and corporate bonds issued in the Hungarian market. The assessment is based on the green bond frameworks, the business profile of each issuer, and the publicly available data of the issuances. The study analyses the seven sectors of the green bond market (real estate, construction, mortgage banks, holding companies, manufacturing, agriculture, wholesale and retail trade). It is proven that out of the sustainable development goals (SDG), SDG 7 is the most supported one. Most issuers plan to use metrics related to pollution prevention, energy efficiency, clean transportation, and water- and wastewater management. Moreover, in four of the seven sectors involved, corporate awareness of green issues could be considered high.

How much does a single negative customer review impact online search and purchase behavior? To answer this question, the authors compare choices made by consumers searching for a product that had a negative review posted on its product-page with those made when the same review had “moved” to a second page as additional reviews were posted. By focusing on where the review appears rather than whether it was submitted, our approach tackles concerns of spurious correlation between customer reviews and unobserved demand shocks. Using data from a large online retailer, we find that the discovery of a negative review – one that has 3-stars or less out of 5 – leads to an average drop in purchase probability of 51.4%, an increase in continuing search for a competing item of 11.4%, and a 15.8% increase in the price paid if a purchase occurs. Our findings are presented on a two-dimensional product map – an innovative way to evaluate the vulnerability of products to a single negative review.

In 2010–2012, new outpatient service locations were established in Hungarian micro-regions, which had lacked such capacities before. We exploit this quasi-experiment to estimate the effect of geographical accessibility on outpatient case numbers using both individual-level and semi-aggregate panel data. We find a 24–27 per cent increase of case numbers as a result of the establishments. Our specialty-by-specialty estimates imply that a 1-min reduction of travel time to the nearest outpatient unit increases case numbers for example by 0.9 per cent in internal care and 3.1 per cent in rheumatology. The size of the new outpatient capacities has a separate effect, raising the possibility of the presence of supplier-induced demand. By combining a fixed-effects logit and a fixed-effects truncated Poisson estimator, we decompose the effects into increases in the probability of ever visiting a doctor on the one hand and an increase of the frequency of visits on the other hand. We find that new visits were dominant in the vast majority of specialties, whereas both margins were important for example in rheumatology. Finally, we demonstrate the usefulness of the fixed-effects truncated Poisson estimator in modelling count data by examining its robustness by simulations. Copyright © 2015 John Wiley & Sons, Ltd.

In 2010-2012, new outpatient service locations were established in Hungarian micro-regions, which had lacked such capacities before. We exploit this quasi-experiment to estimate the effect of geographical accessibility on outpatient case numbers using both individual-level and semi-aggregate panel data. We find a 24-27 per cent increase of case numbers as a result of the establishments. Our specialty-by-specialty estimates imply that a 1-min reduction of travel time to the nearest outpatient unit increases case numbers for example by 0.9 per cent in internal care and 3.1 per cent in rheumatology. The size of the new outpatient capacities has a separate effect, raising the possibility of the presence of supplier-induced demand. By combining a fixed-effects logit and a fixed-effects truncated Poisson estimator, we decompose the effects into increases in the probability of ever visiting a doctor on the one hand and an increase of the frequency of visits on the other hand. We find that new visits were dominant in the vast majority of specialties, whereas both margins were important for example in rheumatology. Finally, we demonstrate the usefulness of the fixed-effects truncated Poisson estimator in modelling count data by examining its robustness by simulations.

The stability (hydrolysis and oxidation) of ipriflavone (7-isopropoxyisoflavone, 1) was studied under basic and acidic conditions in different solvents; the effects of irradiation were investigated in methanol. Identification of the isolated products enabled suggestions to be made concerning the mechanisms of decomposition.

Using data from Portugal’s Fertility and Family Survey, I analyze child- bearing decisions up to the third birth using a split-population (SP) model. The advantage of this approach is the separability of the covariates’ impact on birth tim- ing and birth stopping. This paper is the first to apply an SP model to investigate the effect of unemployment and the availability of childcare. I also address how educa- tion, family size, age at previous birth of the woman and sex composition of existing children influence childbearing decisions, and provide empirical support for each of these. Comparing these with estimates obtained using survival models that do not include a regression on birth stopping suggests that the results of the latter tend to be unreasonable. info:eu-repo/semantics/publishedVersion

The antiostheophorotic agent ipriflavone [7-(1-methyl-ethoxy)-3-phenyl-4H-1-benzopyran-4-one, C18H16O3] is an important member of the isoflavone family. The structure of the molecule is dominated by the dihedral angle (50 degrees) between the planes of the phenyl and benzo-pyran moieties. A structural comparison with other related published structures is represented.

Human leukocyte elastase (HLE) is a serine proteinase, capable of degrading a variety of structural matrix proteins. SSR69071 2-[(4-isopropyl-6-methoxy-1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)methoxy]-9-(2-piperidin-1-ylethoxy)-4H-pyrido[1,2-a]pyrimidin-4-one was selected as a novel orally active HLE inhibitor for treatment of chronic obstructive pulmonary diseases, asthma, emphysema, cystic fibrosis and several inflammatory diseases (WO 01/44245 A1) (J. Pharm. Exp. Ther., submitted for publication).

Aim: To gather and review data describing the epidemiology of schizophrenia and clinical guidelines for schizophrenia therapy in seven Central and Eastern European countries, with a focus on negative symptoms.Methods:A literature search was conducted which included publications from 1995 to 2012 that were indexed in key databases.Results:Reports of mean annual incidence of schizophrenia varied greatly, from 0.04 to 0.58 per 1,000 population. Lifetime prevalence varied from 0.4% to 1.4%. One study reported that at least one negative symptom was present in 57.6% of patients with schizophrenia and in 50–90% of individuals experiencing their first episode of schizophrenia. Primary negative symptoms were observed in 10–30% of patients. Mortality in patients with schizophrenia was greater than in the general population, with a standardized mortality ratio of 2.58–4.30. Reasons for higher risk of mortality in the schizophrenia population included increased suicide risk, effect of schizophrenia on lifestyle and environment, and presence of comorbidities. Clinical guidelines overall supported the use of second-generation antipsychotics in managing negative symptoms of schizophrenia, although improved therapeutic approaches are needed.Conclusion:Schizophrenia is one of the most common mental illnesses and poses a considerable burden on patients and healthcare resources alike. Negative symptoms are present in many patients and there is an unmet need to improve treatment offerings for negative symptoms beyond the use of second-generation antipsychotics and overall patient outcomes.