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3. PD-L1 expression in tongue squamous cell carcinoma

Author

Akisada, Naoki, Nishimoto, Kohei, Takao, Soshi, Gion, Yuka, Marunaka, Hidenori, Tachibana, Tomoyasu, Makino, Takuma, Miki, Kentaro, Akagi, Yusuke, Tsumura, Munechika, Toji, Tomohiro, Yoshino, Tadashi, Nishizaki, Kazunori, Orita, Yorihisa, and Sato, Yasuharu

Published
2021
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6. Degree of pharyngeal deformation caused by pharyngeal endoscopic submucosal dissection is associated with the incidence of aspiration pneumonia

Author

Abe, Makoto, additional, Kawahara, Yoshiro, additional, Obayashi, Yuka, additional, Baba, Yuki, additional, Hamada, Kenta, additional, Sakae, Hiroyuki, additional, Kono, Yoshiyasu, additional, Kanzaki, Hiromitu, additional, Iwamuro, Masaya, additional, Kawano, Seiji, additional, Makino, Takuma, additional, Noda, Yohei, additional, Marunaka, Hidenori, additional, and Okada, Hiroyuki, additional

Published
2023
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12. Lymphoepithelial Carcinoma in the Lateral Tongue: The Case Report

Author

Ono, Sawako, primary, Marunaka, Hidenori, additional, Yanai, Hiroyuki, additional, Kawai, Hotaka, additional, Takabatake, Kiyofumi, additional, Nishida, Kenji, additional, Toji, Tomohiro, additional, Nakano, Keisuke, additional, Nagatsuka, Hitoshi, additional, and Yoshino, Tadashi, additional

Published
2021
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13. Lymphoepithelial Carcinoma in the Lateral Tongue: The Case Report

Author

Ono, Sawako, Marunaka, Hidenori, Yanai, Hiroyuki, Kawai, Hotaka, Takabatake, Kiyofumi, Nishida, Kenji, Toji, Tomohiro, Nakano, Keisuke, Nagatsuka, Hitoshi, Yoshino, Tadashi, Ono, Sawako, Marunaka, Hidenori, Yanai, Hiroyuki, Kawai, Hotaka, Takabatake, Kiyofumi, Nishida, Kenji, Toji, Tomohiro, Nakano, Keisuke, Nagatsuka, Hitoshi, and Yoshino, Tadashi

Abstract

Lymphoepithelial carcinoma (LEC) of the tongue is a rare subtype of squamous cell carcinoma. Histologically, it is an undifferentiated carcinoma with rich lymphocyte and plasma cell infiltration. The most common location for LEC in the head and neck is the salivary glands, and LEC of the oral cavity is extremely rare. The second case report of LEC in the lateral tongue is presented. In addition, a review of the literature was performed, and the relationship between LEC and Epstein-Barr virus infection was considered.

Published
2021

16. Correction to: PD-L1 expression in tongue squamous cell carcinoma

Author

Akisada, Naoki, primary, Nishimoto, Kohei, additional, Takao, Soshi, additional, Gion, Yuka, additional, Marunaka, Hidenori, additional, Tachibana, Tomoyasu, additional, Makino, Takuma, additional, Miki, Kentaro, additional, Akagi, Yusuke, additional, Tsumura, Munechika, additional, Toji, Tomohiro, additional, Yoshino, Tadashi, additional, Nishizaki, Kazunori, additional, Orita, Yorihisa, additional, and Sato, Yasuharu, additional

Published
2020
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18. PD-L1 expression in tongue squamous cell carcinoma

Author

Akisada, Naoki, primary, Nishimoto, Kohei, additional, Takao, Soshi, additional, Gion, Yuka, additional, Marunaka, Hidenori, additional, Tachibana, Tomoyasu, additional, Makino, Takuma, additional, Miki, Kentaro, additional, Akagi, Yusuke, additional, Tsumura, Munechika, additional, Toji, Tomohiro, additional, Yoshino, Tadashi, additional, Nishizaki, Kazunori, additional, Orita, Yorihisa, additional, and Sato, Yasuharu, additional

Published
2020
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21. Computed Tomography Findings for Diagnosing Follicular Thyroid Neoplasms

Author

Makino, Takuma, Orita, Yorihisa, Tachibana, Tomoyasu, Marunaka, Hidenori, Miki, Kentaro, Akisada, Naoki, Akagi, Yusuke, Usui, Yoshiyuki, Sato, Yasuharu, Yoshino, Tadashi, and Nishizaki, Kazunori

Subjects
Adult, Aged, 80 and over, Male, Adolescent, computed tomography, Middle Aged, preoperative diagnosis, follicular thyroid carcinoma, Young Adult, follicular thyroid adenoma, Humans, Female, Thyroid Neoplasms, Tomography, X-Ray Computed, Aged
Abstract

Since no diagnostic method has been established to distinguish follicular thyroid carcinoma (FTC) from follicular thyroid adenoma (FTA), surgery has been the only way to reach a diagnosis of follicular neoplasm. Here we investigated the computed tomography (CT) features of follicular neoplasms, toward the goal of being able to identify specific CT features allowing the preoperative differentiation of FTC from FTA. We retrospectively analyzed the cases of 205 patients who underwent preoperative CT of the neck and were histopathologically diagnosed with FTC (n=31) or FTA (n=174) after surgery between January 2002 and June 2016 at several hospitals in Japan. In each of these 205 cases, non-enhanced and contrast-enhanced CT images were obtained, and we analyzed the CT features. On univariate analysis, inhomogeneous features of tumor lesions on contrast-enhanced CT were more frequently observed in FTC than in FTA (p=0.0032). A multivariate analysis identified inhomogeneous features of tumor lesions on contrast-enhanced CT images as an independent variable indicative of FTC (p=0.0023). CT thus offers diagnostic assistance in distinguishing FTC from FTA.

Published
2018

22. KRAS mutations in tongue squamous cell carcinoma

Author

Akagi, Yusuke, primary, Tachibana, Tomoyasu, additional, Orita, Yorihisa, additional, Gion, Yuka, additional, Marunaka, Hidenori, additional, Makino, Takuma, additional, Miki, Kentaro, additional, Akisada, Naoki, additional, Yoshino, Tadashi, additional, Nishizaki, Kazunori, additional, and Sato, Yasuharu, additional

Published
2019
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23. Young adult patients with squamous cell carcinoma of the tongue strongly express p16 without human papillomavirus infection

Author

Tachibana, Tomoyasu, primary, Orita, Yorihisa, additional, Gion, Yuka, additional, Miki, Kentaro, additional, Ikegami, Kana, additional, Marunaka, Hidenori, additional, Makino, Takuma, additional, Akagi, Yusuke, additional, Akisada, Naoki, additional, Tsumura, Munechika, additional, Ito, Toshihiro, additional, Yoshino, Tadashi, additional, Nishizaki, Kazunori, additional, and Sato, Yasuharu, additional

Published
2019
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27. Neck metastasis in patients with T1-2 supraglottic cancer

Author

Tachibana, Tomoyasu, primary, Orita, Yorihisa, additional, Marunaka, Hidenori, additional, Makihara, Sei-ichiro, additional, Hirai, Misato, additional, Gion, Yuka, additional, Ikegami, Kana, additional, Miki, Kentaro, additional, Makino, Takuma, additional, Noyama, Yasuyuki, additional, Komatsubara, Yasutoshi, additional, Kimura, Miyuki, additional, Yoshino, Tadashi, additional, Nishizaki, Kazunori, additional, and Sato, Yasuharu, additional

Published
2018
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28. Glottic cancer in patients without complaints of hoarseness

Author

Tachibana, Tomoyasu, primary, Orita, Yorihisa, additional, Marunaka, Hidenori, additional, Makihara, Seiichiro, additional, Hirai, Misato, additional, Miki, Kentaro, additional, Ogawara, Yuya, additional, Ishihara, Hisashi, additional, Matsuyama, Yuko, additional, Abe-Fujisawa, Iku, additional, Shimizu, Aiko, additional, Sato, Yasuharu, additional, and Nishizaki, Kazunori, additional

Published
2018
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29. Tumor-Associated Macrophages in the Development of 4-Nitroquinoline-1-Oxide-Induced Tongue Squamous Cell Carcinoma in a Mouse Model

Author

Miki, Kentaro, primary, Orita, Yorihisa, additional, Gion, Yuka, additional, Takao, Soshi, additional, Ohno, Kyotaro, additional, Takeuchi, Mai, additional, Ito, Toshihiro, additional, Minoura, Akira, additional, Tachibana, Tomoyasu, additional, Marunaka, Hidenori, additional, Makino, Takuma, additional, Matsukawa, Akihiro, additional, Nishizaki, Kazunori, additional, Yoshino, Tadashi, additional, and Sato, Yasuharu, additional

Published
2017
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30. A case of neuro‐Behcet's disease preceded by cellulitis‐like cutaneous arteritis and multiple pharyngeal ulcers.

Author

Yokoyama, Emi, Kawakami, Yoshio, Katsuyama, Takayuki, Marunaka, Hidenori, and Morizane, Shin

Subjects
ARTERITIS, BEHCET'S disease, TAKAYASU arteritis, ULCERS, LEUCOCYTES, LEUKOCYTOCLASTIC vasculitis
Abstract

A case of neuro-Behcet's disease preceded by cellulitis-like cutaneous arteritis and multiple pharyngeal ulcers Behcet's disease (BD) is a multisystem relapsing inflammatory disorder of unknown cause. The Chapel Hills Consensus Conference 2012 classified BD vasculitis as variable vessel vasculitis, and its lesions are distributed in the arteriovenous vessels, regardless of vessel size.[3] Arterial lesions are rare in BD. [Extracted from the article]

Published
2023
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33. A Clinical Study on 64 Cases of Laryngeal Granuloma

Author

Tachibana, Tomoyasu, primary, Orita, Yorihisa, additional, Makino, Takuma, additional, Ogawara, Yuya, additional, Matsuyama, Yuko, additional, Shimizu, Aiko, additional, Nakada, Michihiro, additional, Marunaka, Hidenori, additional, and Nishizaki, Kazunori, additional

Published
2016
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34. Glottic cancer in patients without complaints of hoarseness

Author

Tachibana, Tomoyasu, primary, Orita, Yorihisa, additional, Marunaka, Hidenori, additional, Makihara, Seiichiro, additional, Hirai, Misato, additional, Miki, Kentaro, additional, Ogawara, Yuya, additional, Ishihara, Hisashi, additional, Matsuyama, Yuko, additional, Abe–Fujisawa, Iku, additional, Shimizu, Aiko, additional, Sato, Yasuharu, additional, and Nishizaki, Kazunori, additional

Published
2015
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35. How long should we continue S-1 as adjuvant chemotherapy for squamous cell carcinoma of the head and neck?

Author

Hirai, Misato, primary, Orita, Yorihisa, additional, Takao, Soshi, additional, Tachibana, Tomoyasu, additional, Marunaka, Hidenori, additional, Makihara, Seiichiro, additional, Miki, Kentaro, additional, Noyama, Yasuyuki, additional, Fuji, Sayaka, additional, Torigoe, Akiko, additional, Sato, Yasuharu, additional, and Nishizaki, Kazunori, additional

Published
2015
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36. Leriche operation for parotid gland pathology

Author

Orita, Yorihisa, primary, Ogawara, Toshiaki, additional, Endo, Ryutaro, additional, Fuji, Sayaka, additional, Miki, Kentaro, additional, Hirai, Misato, additional, Noda, Yohei, additional, Marunaka, Hidenori, additional, Tachibana, Tomoyasu, additional, Sato, Yasuharu, additional, and Nishizaki, Kazunori, additional

Published
2014
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39. Novel and simple prognostic index for nasal natural killer/T‐cell lymphoma

Author

Hanakawa, Hiroyuki, primary, Orita, Yorihisa, additional, Sato, Yasuharu, additional, Takao, Soshi, additional, Marunaka, Hidenori, additional, Morishita, Tokiwa, additional, Yamashita, Yasuhiko, additional, Hori, Yasutaka, additional, Domae, Shuhei, additional, Inokuchi, Ikuo, additional, Akagi, Seiko, additional, Kondo, Eisei, additional, Iwaki, Noriko, additional, Motomiya, Kana, additional, Okumura, Hirokazu, additional, Yoshino, Tadashi, additional, and Nishizaki, Kazunori, additional

Published
2013
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41. Characteristic ultrasound features of mucosa-associated lymphoid tissue lymphoma of the salivary and thyroid gland.

Author

Orita, Yorihisa, Sato, Yasuharu, Kimura, Nobuhiko, Marunaka, Hidenori, Tachibana, Tomoyasu, Yamashita, Yasuhiko, Hanakawa, Hiroyuki, Yoshino, Tadashi, and Nishizaki, Kazunori

Subjects
B cell lymphoma, ULTRASONIC imaging, IMMUNOHISTOCHEMISTRY, ACADEMIC medical centers, HEAD tumors, HISTOLOGICAL techniques, NECK tumors, SALIVARY glands, THYROID gland, DESCRIPTIVE statistics, DIAGNOSIS
Abstract

Conclusion: The characteristic ultrasound appearance of mucosa-associated lymphoid tissue (MALT) lymphoma of the head and neck provides diagnostic information regarding masses or swellings in the head and neck region. Objectives: There are only a few reports about ultrasound features of malignant lymphoma (ML) of the head and neck. We have noticed that the ultrasound appearances of cases with MALT lymphoma resembled each other even when the appearances of other images like computed tomography were absolutely different. The objective of this study was to delineate the reliability of this characteristic ultrasound appearance of MALT lymphoma of the head and neck. Methods: The ultrasound examinations of 30 patients with histopathologically proven primary ML of the head and neck (15 cases of MALT) were reviewed. The ultrasound results of each case were independently compared to the results of the histopathological examination. Results: Two ultrasound patterns were observed for MALT lymphoma. The first was characterized by a marked hypoechoic area with interspersed linear echogenic strands (linear echogenic strands pattern), and the second was characterized by multiple, relatively large, hypoechoic segments (segmental pattern). Histopathologically, these patterns could be explained on the basis of the expansion of lymphoma cells demarcated by narrow or wide fibrous bands. [ABSTRACT FROM AUTHOR]

Published
2014
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42. The Diagnostic Capacity of Pre-treatment 18F-FDG PET/CT for Predicting the Extranodular Spread of Lymph Node Metastases in Patients with Oral Squamous Cell Carcinoma.

Author

Fukuhara R, Shinya T, Fukuma S, Ogawa N, Masaoka Y, Tanaka T, Marunaka H, Arioka T, Hiraki T, Kaji M, and Kanazawa S

Subjects
Adult, Aged, Aged, 80 and over, Case-Control Studies, Female, Fluorodeoxyglucose F18 administration & dosage, Humans, Lymphatic Metastasis pathology, Male, Middle Aged, Mouth Neoplasms diagnostic imaging, Mouth Neoplasms therapy, ROC Curve, Radiopharmaceuticals administration & dosage, Retrospective Studies, Squamous Cell Carcinoma of Head and Neck diagnostic imaging, Squamous Cell Carcinoma of Head and Neck therapy, Lymphatic Metastasis diagnosis, Mouth Neoplasms pathology, Positron Emission Tomography Computed Tomography methods, Squamous Cell Carcinoma of Head and Neck pathology
Abstract

The aim of this study was to evaluate the ability of pretreatment 90-min 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) to predict the extranodular spread of lymph node metastases in oral squamous cell carcinoma. We retrospectively reviewed the cases of 56 patients who underwent pretreatment 18F-FDG PET/CT and surgery with neck dissection. Maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis were measured for the 56 primary sites and maximum standardized uptake value was measured for 115 lymph node levels. Extranodular spread was present at 9 lymph node levels in 7 patients. Significant differences were found in metabolic tumor volume and total lesion glycolysis of the primary site, and in lymph node maximum standardized uptake value, between patients with and without extranodular spread (p<0.05). Combining primary site total lesion glycolysis and lymph node maximum standardized uptake volume at their respective optimal cutoffs, the sensitivity, specificity, and accuracy for predicting extranodular spread were 89%, 92%, and 92%, respectively. Pretreatment 18F-FDG PET/CT is useful for predicting extranodular spread in patients with oral squamous cell carcinoma. The combined use of primary site total lesion glycolysis and lymph node maximum standardized uptake value showed greater predictive value than either predictor singly., Competing Interests: No potential conflict of interest relevant to this article was reported.

Published
2020
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43. Clinicopathological Features and Outcomes of Endoscopic Submucosal Dissection for Superficial Cancer of the Pharynx.

Author

Abe M, Iwamuro M, Kawahara Y, Kanzaki H, Kawano S, Tanaka T, Tsumura M, Makino T, Noda Y, Marunaka H, Nishizaki K, and Okada H

Subjects
Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell pathology, Female, Humans, Male, Margins of Excision, Middle Aged, Pharyngeal Neoplasms pathology, Retrospective Studies, Survival Rate, Carcinoma, Squamous Cell surgery, Endoscopic Mucosal Resection methods, Pharyngeal Neoplasms surgery
Abstract

The efficacy and safety of endoscopic submucosal dissection (ESD) for superficial cancer of the pharynx are still unclear. To identify clinicopathological features of superficial pharyngeal cancer, and the efficacy and safety of ESD, we retrospectively assessed 70 pharyngeal cancers in 59 patients who underwent ESD. Of these patients, 61.0% and 50.8% had a history of esophageal cancer and head and neck cancer, respectively. The median tumor size was 15 mm, and 75.7% of the lesions were located at the piriform sinus. The en bloc resection rate was 94.9%. Treatment-related adverse events occurred in 8 cases, but there was no treatment-related death. The lateral margin was positive for neoplasm in 3 lesions (4.3%) and inconclusive in 27 lesions (38.6%), but no local recurrence was observed. Cervical lymph node metastasis was observed in 6 patients, and was successfully treated by cervical lymph node dissection. The three-year overall survival rate was 91.5% (95%CI: 76.6-97.3%) and the cause-specific survival rate was 97.6% (95%CI: 84.9-99.7%). In conclusion, ESD for superficial pharyngeal cancer was safe and effective. "Resect and watch" is probably a feasible and rational strategy for treatment of patients with superficial pharyngeal cancer., Competing Interests: No potential conflict of interest relevant to this article was reported.

Published
2019
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44. Diffuse large B-cell lymphoma of the lacrimal sac arising from a patient with IgG4-related disease.

Author

Marunaka H, Orita Y, Tachibana T, Miki K, Makino T, Yoshino T, Nishizaki K, and Sato Y

Subjects
Aged, Female, Humans, Lymphoma, Large B-Cell, Diffuse etiology, Autoimmune Diseases complications, Immunoglobulin G immunology, Lymphoma, Large B-Cell, Diffuse pathology, Nasolacrimal Duct pathology
Abstract

A rare case of diffuse large B-cell lymphoma (DLBCL) possibly induced by IgG4-related disease is described. A 78-year-old woman was presented with a mass of the right lacrimal sac that extended to the inferior nasal meatus through the nasolacrimal duct. Pathological diagnosis was DLBCL with diffuse distribution of IgG4 + cells in the background of this lesion. The chronic inflammatory state of IgG4-related disease could have caused the development of DLBCL.

Published
2018
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45. Laryngeal squamous cell papilloma is highly associated with human papillomavirus.

Author

Orita Y, Gion Y, Tachibana T, Ikegami K, Marunaka H, Makihara S, Yamashita Y, Miki K, Makino T, Akisada N, Akagi Y, Kimura M, Yoshino T, Nishizaki K, and Sato Y

Subjects
Adult, Cyclin-Dependent Kinase Inhibitor p16 metabolism, Female, Humans, Immunohistochemistry, Larynx pathology, Male, Middle Aged, Mouth pathology, Mouth virology, Papillomavirus Infections complications, Papillomavirus Infections pathology, Papillomavirus Infections virology, Polymerase Chain Reaction, Laryngeal Neoplasms pathology, Laryngeal Neoplasms virology, Papilloma pathology, Papilloma virology, Papillomaviridae physiology
Abstract

Objective: To delineate the association between characteristics of adult-onset laryngeal squamous cell papilloma and human papillomavirus (HPV) infection., Methods: Clinical records and paraffin-embedded specimens of 77 papilloma patients who had been treated between 1998 and 2014 were collected. Of the 77 cases, 34 were identified in the larynx, 28 in the oral cavity and 15 in the oropharynx. Specimens were investigated by polymerase chain reaction (PCR) to detect HPV 6, 11, 16, 18, 31, 33, 35, 52b and 58, and immunohistochemical (IHC) staining for anti-p16INK4a antibody., Results: In 21 cases (61.8%) with laryngeal squamous cell papilloma, various types of HPV were detected: 14 cases (41.2%) were positive of high-risk HPV, 18 (52.9%) were positive of low-risk HPV and 11 (32.4%) were positive of both high-risk HPV and low-risk HPV. Younger patients (<60 years) showed a higher rate of HPV infection than older patients. Among the 34 cases with laryngeal papilloma, no malignant transformation was observed during the study period. With IHC staining, positive expression of p16 was observed in 20 cases (58.8%). HPV infection and p16-expression were associated with the pathological finding of koilocytosis. Only four cases (14.3%) showed HPV-positivity in the oral cavity, and none of the 15 oropharyngeal cases were positive for HPV, and none of the oral cavity and oropharyngeal cases showed koilocytosis. Results of HPV-PCR and p16-IHC staining were significantly correlated each other., Conclusions: HPV infection is frequently associated with laryngeal squamous cell papilloma, and koilocytosis is a characteristic pathological finding. To the best of our knowledge, this is the first report which have described infections with multiple HPV types in laryngeal papilloma.

Published
2018
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