Search

Your search keyword '"Marwaha, Pavan Kaur"' showing total 2 results
Start Over Author "Marwaha, Pavan Kaur"
2 results on '"Marwaha, Pavan Kaur"'

2. Prospective, multicentre study of screening, investigation and management of hyponatraemia after subarachnoid haemorrhage in the UK and Ireland

Author

Loan, James J M, Tominey, Steven, Baweja, Kirun, Woodfield, Julie, Chambers, Thomas J G, Haley, Mark, Kundu, Simran S, Tang, H Y Josephine, Wiggins, Anthony N, Poon, Michael T C, Brennan, Paul M, Mohan, Midhun, Goitiandia, Sofia Weiss, Lyons, Adam, Freer-Smith, Charlotte, Kyriacou, Harry, Baker, Olivia, O'Brien, David, Johnson, Jonathan Armitage, Croyle, Jaclyn, McCandless, Conor, Roman, Elena, Dumitrascu, Flavia, Gressmann, Kassandra, Teo, Mario, Lee, Keng Siang, Meghrawi, Khadija, Rees, Nicholas, Mona, Taslima, Mohammed, Wail, Minnock, Eoin, Kundu, Simran, Grufferty, David, Daswani, Harsha, Rajesh, Joel, Kaskun, Oleksandra, Sofela, Agbolahan, Osunronbi, Temidayo, Toma, Arina, Tijare, Chinmay, Ahmad, Reddin, Kam, Sen Yin Melina, Hawkins, Sophie, Stokes, Stuart, Poolovadoo, Yanish, Baker, Jordan, Siddique, Amar Naqash, Othman, Lara, Kehoe, Kristy, Giannakaki, Venetia, Mukerji, Nitin, Carr, Harry, Allison, Callum, Hughes, James T, Cheong, Jeremy, Boukas, Alex, Piper, Rory, Lamb, Catherine, Zorman, Mark Jernej, Latinwo, Rotimi Babajide, Sravanam, Sanskrithi, Bandyopadhyay, Soham, Honeyman, Susan Isabel, Rajashekar, Devika, Jung, Josephine, Sheikh, Mustafa El, Cope, Jack, Mehta, Bhumi, Sanghvi, Hazel, McLean, Lily, Shehab, Mai, Kalra, Neeraj, Anderson, Ian, Khan, Taufiq, Vyas, Neel, John, Anushka, Thomas, Dominic, Kakwani, Mehak, Chan, Vinson Wai-Shun, Matloob, Samir, Bin Jalal, Arif Hanafi, Khan, Mehdi, Ramali, Mohamed Rashad, Asanitthong, Praoparn, Phuah, Yu Zhi, McSorley, Nathan, Robin, Nicole, Hutton, Dana, Kouli, Omar, Kumaria, Ashwin, Chan, Huan Wee, Glancz, Laurence Johann, Hollingworth, Milo, Ingale, Harshal, Bettoli, Giovanna, Cummins, Tom, Frantzias, Joseph, Mehta, Shaily, Mohamed, Aisha Abubakar, Reyhani, Hadis, Sall, Jagbir Kaur, Vyas, Ruchika, Belli, Antonio, Yakoub, Kamal, Lammy, Simon, Tang, Josephine, Hashim Sinan, Laith Osama, Maqsood, Raeesah, Kotikalapudi, Siddharth, Holmes, David, Dasgupta, Debayan, Taqvi, Ahsan Ali, Southey, Charles, Thompson, Alysha, Senior, Harry, Hardcastle, Niamh, Loan, James, Scott, Caroline, Chiu, Jodi, Birt, Katie, Walters, Rachel, Nair, Sanjay Govind, Grundy, Tom, Rooprai, Navleen, Radcliffe, Heather, Nabahin, Maram, Siva, Saranya, Mohammed, Sophia, Galloway, Luke, Zaidi, Syed, Hall, Emily, Sells, Lauren, Namono, Sarah Ferbrache, Paranathala, Menaka, Gough, Melissa, Agarwal, Aastha, Lea, Alexander, Russell, Jordan, Denham, Katherine, Harris, Lauren, Anzak, Anam, Sohrabi, Catrin, Pai, Hari, Dheden, Ngawang, Arora, Sloni, Merola, Joseph, Tze Shan, Tiffany Ye, Merican, Diyanah, Vivian Pak, Hei Yi, Siah, Qi Zhuang, Yang Ooi, Setthasorn Zhi, Chia, Wen Li, Hall, Samuel, Marwaha, Pavan Kaur, Robbin, Kiran, Millward, Christopher P, George, Alan M, Foster, Kate, Patel, Parthik, Bahl, Sarthak, and On behalf of the Sodium after Subarachnoid Haemorrhage (SaSH) audit collaborators

Abstract

Background: Hyponatraemia often occurs after subarachnoid haemorrhage (SAH). However, its clinical significance and optimal management are uncertain. We audited the screening, investigation and management of hyponatraemia after SAH. Methods: We prospectively identified consecutive patients with spontaneous SAH admitted to neurosurgical units in the United Kingdom or Ireland. We reviewed medical records daily from admission to discharge, 21 days or death and extracted all measurements of serum sodium to identify hyponatraemia (10 days. Associations of hyponatraemia with outcome were assessed using logistic regression with adjustment for predictors of outcome after SAH and admission duration. We assessed hyponatraemia-free survival using multivariable Cox regression. Results: 175/407 (43%) patients admitted to 24 neurosurgical units developed hyponatraemia. 5976 serum sodium measurements were made. Serum osmolality, urine osmolality and urine sodium were measured in 30/166 (18%) hyponatraemic patients with complete data. The most frequently target daily fluid intake was >3 L and this did not differ during hyponatraemic or non-hyponatraemic episodes. 26% (n/N=42/164) patients with hyponatraemia received sodium supplementation. 133 (35%) patients were dead or dependent within the study period and 240 (68%) patients had hospital admission for over 10 days. In the multivariable analyses, hyponatraemia was associated with less dependency (adjusted OR (aOR)=0.35 (95% CI 0.17 to 0.69)) but longer admissions (aOR=3.2 (1.8 to 5.7)). World Federation of Neurosurgical Societies grade I–III, modified Fisher 2–4 and posterior circulation aneurysms were associated with greater hazards of hyponatraemia. Conclusions: In this comprehensive multicentre prospective-adjusted analysis of patients with SAH, hyponatraemia was investigated inconsistently and, for most patients, was not associated with changes in management or clinical outcome. This work establishes a basis for the development of evidence-based SAH-specific guidance for targeted screening, investigation and management of high-risk patients to minimise the impact of hyponatraemia on admission duration and to improve consistency of patient care.

Published
2022

Catalog

Books, media, physical & digital resources
See catalog results