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3. Preliminary Material

Author

Kleinöder, Nina, primary, Marx, Christian, additional, Gehlen, Boris, additional, and Czierpka, Juliane, additional

Published
2024
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6. Selective weed control using laser techniques

Author

Marx, Christian, Pastrana-Perez, Julio, Hustedt, Michael, Barcikowski, Stephan, Haferkamp, Heinz, and Rath, Thomas

Subjects
Laser-Applikation, Schädigungsmodell, Unkrautbekämpfung, Zielfindung, damage model, laser application, targeting, weed control, Agriculture, Botany, QK1-989
Abstract

This contribution discusses technical and growth relevant aspects of using laser techniques for weed control. The research on thermal weed control via laser first focused on the interaction of laser beams and weed plants. Due to preliminary studies, a CO2-laser was selected for further studies with regard to the process factors laser energy, laser spot area, coverage of the weeds meristem, weed species (Amaranthus retroflexus), and weed growth stage. Thereby, the laser damage was modeled in order to control the necessary laser output power online. Furthermore, the beam positioning leading to an effective damaging of the weeds was investigated and a test device was designed. With the aid of contemporary image processing algorithms for weed recognition and meristem determination, a laser and servo-motor control was developed. Most of the studies presented in this paper were part of the project “Investigations on laser light affected weed control of juvenile plants with the aid of image processing” funded by the Deutsche Forschungsgemeinschaft.

Published
2012
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9. Mechanistic insights into p53‐regulated cytotoxicity of combined entinostat and irinotecan against colorectal cancer cells

Author

Marx, Christian, Sonnemann, Jürgen, Beyer, Mandy, Maddocks, Oliver DK, Lilla, Sergio, Hauzenberger, Irene, Piée‐Staffa, Andrea, Siniuk, Kanstantsin, Nunna, Suneetha, Marx‐Blümel, Lisa, Westermann, Martin, Wagner, Tobias, Meyer, Felix B, Thierbach, René, Mullins, Christina S, Kdimati, Said, Linnebacher, Michael, Neri, Francesco, Heinzel, Thorsten, Wang, Zhao‐Qi, and Krämer, Oliver H

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Colo-Rectal Cancer, Digestive Diseases, Genetics, Cancer, Aetiology, 2.1 Biological and endogenous factors, Acetylation, Animals, Apoptosis, Benzamides, Colorectal Neoplasms, Humans, Irinotecan, Mice, Pyridines, Tumor Suppressor Protein p53, acetylation, apoptosis, BAK, mitochondria, p53, replication stress, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

Late-stage colorectal cancer (CRC) is still a clinically challenging problem. The activity of the tumor suppressor p53 is regulated via post-translational modifications (PTMs). While the relevance of p53 C-terminal acetylation for transcriptional regulation is well defined, it is unknown whether this PTM controls mitochondrially mediated apoptosis directly. We used wild-type p53 or p53-negative human CRC cells, cells with acetylation-defective p53, transformation assays, CRC organoids, and xenograft mouse models to assess how p53 acetylation determines cellular stress responses. The topoisomerase-1 inhibitor irinotecan induces acetylation of several lysine residues within p53. Inhibition of histone deacetylases (HDACs) with the class I HDAC inhibitor entinostat synergistically triggers mitochondrial damage and apoptosis in irinotecan-treated p53-positive CRC cells. This specifically relies on the C-terminal acetylation of p53 by CREB-binding protein/p300 and the presence of C-terminally acetylated p53 in complex with the proapoptotic BCL2 antagonist/killer protein. This control of C-terminal acetylation by HDACs can mechanistically explain why combinations of irinotecan and entinostat represent clinically tractable agents for the therapy of p53-proficient CRC.

Published
2021

14. Serum Potassium and Risk of Death or Kidney Replacement Therapy in Older People With CKD Stages 4-5: Eight-Year Follow-up

Author

Schneider, Andreas, Torp, Anke, Iwig, Beate, Perras, Boris, Marx, Christian, Drechsler, Christiane, Blaser, Christof, Wanner, Christoph, Emde, Claudia, Krieter, Detlef, Fuchs, Dunja, Irmler, Ellen, Platen, Eva, Schmidt-Gürtler, Hans, Schlee, Hendrik, Naujoks, Holger, Schlee, Ines, Cäsar, Sabine, Beige, Joachim, Röthele, Jochen, Mazur, Justyna, Hahn, Kai, Blouin, Katja, Neumeier, Katrin, Anding-Rost, Kirsten, Schramm, Lothar, Hopf, Monika, Wuttke, Nadja, Frischmuth, Nikolaus, Ichtiaris, Pawlos, Kirste, Petra, Schulz, Petra, Aign, Sabine, Biribauer, Sandra, Manan, Sherin, Röser, Silke, Heidenreich, Stefan, Palm, Stephanie, Schwedler, Susanne, Delrieux, Sylke, Renker, Sylvia, Schättel, Sylvia, Stephan, Theresa, Schmiedeke, Thomas, Weinreich, Thomas, Leimbach, Til, Stövesand, Torsten, Bahner, Udo, Seeger, Wolfgang, Cupisti, Adamasco, Sagliocca, Adelia, Ferraro, Alberto, Mele, Alessandra, Naticchia, Alessandro, Còsaro, Alex, Ranghino, Andrea, Stucchi, Andrea, Pignataro, Angelo, De Blasio, Antonella, Pani, Antonello, Tsalouichos, Aris, Antonio, Bellasi, Alessandra, Butti, Abaterusso, Cataldo, Somma, Chiara, D’alessandro, Claudia, Torino, Claudia, de Rooij, Esther N.M., de Fijter, Johan W., Le Cessie, Saskia, Hoorn, Ewout J., Jager, Kitty J., Chesnaye, Nicholas C., Evans, Marie, Windahl, Karin, Caskey, Fergus J., Szymczak, Maciej, Dekker, Friedo W., and Hoogeveen, Ellen K.

Published
2023
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23. Predicting Kidney Failure, Cardiovascular Disease and Death in Advanced CKD Patients

Author

Cupisti, Adamasco, Sagliocca, Adelia, Ferraro, Alberto, Musiała, Aleksandra, Mele, Alessandra, Naticchia, Alessandro, Còsaro, Alex, Woodman, Alistair, Ranghino, Andrea, Stucchi, Andrea, Jonsson, Andreas, Schneider, Andreas, Pignataro, Angelo, Schrander, Anita, Torp, Anke, McKeever, Anna, Szymczak, Anna, Blom, Anna-Lena, De Blasio, Antonella, Pani, Antonello, Tsalouichos, Aris, Ullah, Asad, McLaren, Barbara, van Dam, Bastiaan, Iwig, Beate, Antonio, Bellasi, Di Iorio, Biagio Raffaele, Rogland, Björn, Perras, Boris, Alessandra, Butti, Harron, Camille, Wallquist, Carin, Siegert, Carl, Barrett, Carla, Gaillard, Carlo, Garofalo, Carlo, Abaterusso, Cataldo, Beerenhout, Charles, O'Toole, Charlotte, Somma, Chiara, Marx, Christian, Summersgill, Christina, Blaser, Christof, D'alessandro, Claudia, Emde, Claudia, Zullo, Claudia, Pozzi, Claudio, Geddes, Colin, Verburgh, Cornelis, Bergamo, Daniela, Ciurlino, Daniele, Motta, Daria, Glowski, Deborah, McGlynn, Deborah, Vargas, Denes, Krieter, Detlef, Russo, Domenico, Fuchs, Dunja, Sands, Dympna, Hoogeveen, Ellen, Irmler, Ellen, Dimény, Emöke, Favaro, Enrico, Platen, Eva, Olczyk, Ewelina, Hoorn, Ewout, Vigotti, Federica, Ansali, Ferruccio, Conte, Ferruccio, Cianciotta, Francesca, Giacchino, Francesca, Cappellaio, Francesco, Pizzarelli, Francesco, Sundelin, Fredrik, Uhlin, Fredrik, Greco, Gaetano, Roy, Geena, Porto, Gaetana, Bigatti, Giada, Marinangeli, Giancarlo, Cabiddu, Gianfranca, Hirst, Gillian, Fumagalli, Giordano, Caloro, Giorgia, Piccoli, Giorgina, Capasso, Giovanbattista, Gambaro, Giovanni, Tognarelli, Giuliana, Bonforte, Giuseppe, Conte, Giuseppe, Toscano, Giuseppe, Del Rosso, Goffredo, Welander, Gunilla, Augustyniak-Bartosik, Hanna, Boots, Hans, Schmidt-Gürtler, Hans, King, Hayley, McNally, Helen, Schlee, Hendrik, Boom, Henk, Naujoks, Holger, Masri-Senghor, Houda, Murtagh, Hugh, Rayner, Hugh, Miśkowiec-Wiśniewska, Ilona, Schlee, Ines, Capizzi, Irene, Hernandez, Isabel Bascaran, Baragetti, Ivano, Manitius, Jacek, Turner, Jane, Eijgenraam, Jan-Willem, Kooman, Jeroen, Beige, Joachim, Pondel, Joanna, Wilcox, Joanne, Berdeprado, Jocelyn, Röthele, Jochen, Wong, Jonathan, Rotmans, Joris, Banda, Joyce, Mazur, Justyna, Hahn, Kai, Jędrzejak, Kamila, Nowańska, Katarzyna, Blouin, Katja, Neumeier, Katrin, Jones, Kirsteen, Anding-Rost, Kirsten, Gröntoft, Knut-Christian, Oldrizzi, Lamberto, Haydock, Lesley, Vogt, Liffert, Wilkinson, Lily, Gesualdo, Loreto, Schramm, Lothar, Biancone, Luigi, Nowak, Łukasz, Raasveld, Maarten, Durlik, Magdalena, Magnano, Manuela, Vervloet, Marc, Ricardi, Marco, Carmody, Margaret, Di Bari, Maria, Laudato, Maria, Sirico, Maria Luisa, Stendahl, Maria, Svensson, Maria, Weetman, Maria, van Buren, Marjolijn, Joinson, Martin, Ferraresi, Martina, Dutton, Mary, van Diepen, Merel, Matthews, Michael, Provenzano, Michele, Hopf, Monika, Malaguti, Moreno, Wuttke, Nadja, Morgan, Neal, Palmieri, Nicola, Frischmuth, Nikolaus, Bleakley, Nina, Murrone, Paola, Cockwell, Paul, Leurs, Paul, Roderick, Paul, Voskamp, Pauline, Kashioulis, Pavlos, Ichtiaris, Pawlos, Blankestijn, Peter, Kirste, Petra, Schulz, Petra, Mason, Phil, Kalra, Philip, Cirillo, Pietro, Dattolo, Pietro, Acampora, Pina, Sajith, Rincy, Nigro, Rita, Boero, Roberto, Scarpioni, Roberto, Sicoli, Rosa, Malandra, Rosella, Aign, Sabine, Cäsar, Sabine, van Esch, Sadie, Chapman, Sally, Biribauer, Sandra, Navjee, Santee, Crosbie, Sarah, Brown, Sharon, Tickle, Sheila, Manan, Sherin, Röser, Silke, Savoldi, Silvana, Bertoli, Silvio, Borrelli, Silvio, Boorsma, Siska, Heidenreich, Stefan, Melander, Stefan, Maxia, Stefania, Maffei, Stefano, Mangano, Stefano, Palm, Stephanie, Konings, Stijn, Mathavakkannan, Suresh, Schwedler, Susanne, Delrieux, Sylke, Renker, Sylvia, Schättel, Sylvia, Dorota, Szyszkowska, Cicchetti, Teresa, Nieszporek, Teresa, Stephan, Theresa, Schmiedeke, Thomas, Weinreich, Thomas, Leimbach, Til, Rappa, Tiziana, Almquist, Tora, Stövesand, Torsten, Bahner, Udo, Jensen, Ulrika, Palazzo, Valentina, De Simone, Walter, Seeger, Wolfgang, Kuan, Ying, Heleniak, Zbigniew, Aydin, Zeynep, Ramspek, Chava L., Boekee, Rosemarijn, Evans, Marie, Heimburger, Olof, Snead, Charlotte M., Caskey, Fergus J., Torino, Claudia, Szymczak, Maciej, Krajewska, Magdalena, Drechsler, Christiane, Wanner, Christoph, Chesnaye, Nicholas C., Jager, Kitty J., Dekker, Friedo W., Snoeijs, Maarten G.J., and Rotmans, Joris I.

Published
2022
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31. Rectification of position data of Scotland in Ptolemy's Geographike Hyphegesis

Author

Marx, Christian

Subjects
Physics - History and Philosophy of Physics, 62P99
Abstract

The ancient geographic coordinates given for places of Great Britain in Ptolemy's Geographike Hyphegesis are investigated by means of geodetic methods. The turning of Scotland to the east is modelled by a three-dimensional rotation. On the basis of different data sets of control points, the parameters of the rotation are estimated by means of methods of adjustment theory. Furthermore, a geodetic-statistical analysis method is applied to Scotland, by which groups of places of homogenous distortions and modern counterparts of the ancient places are determined. Based on the results of the investigations, answers are given for questions concerning Ptolemaic positions unsolved so far., Comment: 28 pages, 8 figures; author-generated postprint; the final publication is available at Maney Publishing via http://dx.doi.org/10.1179/1752270613Y.0000000085

Published
2015
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36. Investigations of the coordinates in Ptolemy's Geographike Hyphegesis Book 8

Author

Marx, Christian

Subjects
Physics - History and Philosophy of Physics, 01A20
Abstract

In Book 8 of his Geographike Hyphegesis Ptolemy gives coordinates for ca. 360 so-called noteworthy cities. These coordinates are the time difference to Alexandria, the length of the longest day, and partly the ecliptic distance from the summer solstice. The supposable original conversions between the coordinates in Book 8 and the geographical coordinates in the location catalogue of Books 2-7 including the underlying parameters and tabulations are here reconstructed. The results document the differences between the $\Omega$- and $\Xi$-recension. The known difference in the longitude of Alexandria underlying the conversion of the longitudes is examined more closely. For the ecliptic distances from the summer solstice of the $\Omega$-recension it is revealed that they were originally computed by means of a so far undiscovered approximate, linear conversion. Further it is shown that the lengths of the longest day could be based on a linear interpolation of the data in the Mathematike Syntaxis 2.6., Comment: 28 pages, 11 figures; author generated postprint; the final publication is available at Springer via http://dx.doi.org/10.1007/s00407-012-0102-0

Published
2015
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37. Analysis of the latitudinal data of Eratosthenes and Hipparchus

Author

Marx, Christian

Subjects
Physics - History and Philosophy of Physics, 01A20
Abstract

The handed down latitudinal data ascribed to Eratosthenes and Hipparchus are composed and each tested for consistency by means of adjustment theory. For detected inconsistencies new explanations are given concerning the origin of the data. Several inconsistent data can be ascribed to Strabo. Differences in Hipparchus' data can often be explained by the different types and precision of the data. Gross errors in Eratosthenes' data are explained by their origination from the lengths of sea routes. From Eratosthenes' data concerning Thule a numerical value for Eratosthenes' obliquity of the ecliptic is deduced., Comment: 31 pages, 6 figures

Published
2014
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39. Impact of drought hazards on flow regimes in anthropogenically impacted streams: an isotopic perspective on climate stress.

Author

Warter, Maria Magdalena, Tetzlaff, Dörthe, Marx, Christian, and Soulsby, Chris

Subjects
RUNOFF, URBAN runoff, DROUGHT management, RAINFALL, DROUGHTS, MUNICIPAL water supply, SEWAGE
Abstract

Flow regimes are increasingly impacted by more extreme natural hazards of droughts and floods as a result of climate change, compounded by anthropogenic influences in both urban and intensively managed rural catchments. However, the characteristics of sustainable flow regimes that are needed to maintain or restore hydrologic, biogeochemical and ecological function under rapid global change remain unclear and contested. We conducted an inter-comparison of two streams in the Berlin-Brandenburg region of NE Germany, which are both mesoscale sub-catchments of the River Spree; an intermittent rural agricultural stream (the Demnitzer Millcreek) and a heavily anthropogenically impacted urban stream (the Panke). Through tracer-based analyses using stable water isotopes, we identified the dominant physical processes (runoff sources, flowpaths and age characteristics) sustaining streamflow over multiple years (2018–2023), including three major drought years (2018–20, 2021–22). In the urban stream, low flows are regulated through artificially increased baseflow from treated waste water effluent (by up to 80 %), whilst storm drainage drives rapid, transient high flow and runoff responses (up to 80 %) to intense convective summer rainfall. The intermittent groundwater-dominated rural stream experienced extended no-flow periods during drought years (⁓ 60 % of the year), and only moderate storm runoff coefficients (<10 %) in winter along near-surface flows paths after heavy rainfall. In both streams, groundwater dominance with young water influence prevails, with low water ages in the urban stream (<10 %) despite significant urban runoff, and higher ones in the rural stream (⁓15 %). Urban cover resulted in mean transit time of ⁓4 years compared to arable land with ⁓3 years, highlighting the interlinkages of landuse and catchment properties on catchment transit times. Understanding seasonal and interannual variability in streamflow generation through a tracer-based hydrological template, has potential for assessing the impacts of natural hazards on the sustainability of future baseflow management, including wider water quality and ecological implications across anthropogenically impacted environments. [ABSTRACT FROM AUTHOR]

Published
2024
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