1. Reproducibililty of 99Tcm-MAG3 clearance in normal volunteers with the two-sample method
- Author
-
Naoto Watanabe, Masanari Kageyama, Masashi Shimizu, Inagaki S, K. Kameda, T. Kanazawa, Hikaru Seto, S. Toyoshima, and G Tomizawa
- Subjects
Adult ,Male ,Reproducibility ,Metabolic Clearance Rate ,business.industry ,Reproducibility of Results ,Mean age ,General Medicine ,Technetium Tc 99m Mertiatide ,Iodine Radioisotopes ,Clinical Practice ,Normal volunteers ,Method comparison ,Reference Values ,Healthy volunteers ,Humans ,Medicine ,Female ,Iodohippuric Acid ,Radiology, Nuclear Medicine and imaging ,Two sample ,Radiopharmaceuticals ,business ,Nuclear medicine ,Volunteer - Abstract
The aim of this study was to evaluate the reproducibility of 99Tcm-mercaptoacetyltriglycine (99Tcm-MAG3) clearance and to compare it with that of 131I-orthoiodohippurate (131I-OIH), which is widely used in clinical practice. Twelve young healthy volunteers with a mean age of 23.4 years (range 19-28) were enrolled in the study. The investigations were repeated at an interval of 1 month under similar physiological conditions. Each volunteer received a simultaneous injection of 99Tcm-MAG3 and 131I-OIH that was commercially available in an already labelled form. Blood samples were obtained at 44 and 104 min post-injection. Clearance values were calculated using the two-sample method. The mean (+/- S.D.) change from the first to the second measurement was -7.1 +/- 11.1% for 99Tcm-MAG3 and 1.7 +/- 13.6% for 131I-OIH. There were no significant differences between the first and the second measurements of 99Tcm-MAG3 and 131I-OIH clearance, respectively. 99Tcm-MAG3 clearance was shown to be very similar to that of 131I-OIH in healthy volunteers.
- Published
- 1998
- Full Text
- View/download PDF