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1. Long-term impact of baseline serum uric acid levels on living kidney donors: a retrospective study

Author

Kosuke Tanaka, Shigeyoshi Yamanaga, Yuji Hidaka, Sho Nishida, Kohei Kinoshita, Akari Kaba, Toshinori Ishizuka, Satoshi Hamanoue, Kenji Okumura, Chiaki Kawabata, Mariko Toyoda, Akira Miyata, Masayuki Kashima, and Hiroshi Yokomizo

Subjects
Serum uric acid, Living kidney donors, Adverse events, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Abstract Background Preoperative characteristics of living kidney donors are commonly considered during donor selection and postoperative follow-up. However, the impact of preoperative uric acid (UA) levels is poorly documented. The aim of this study was to evaluate the association between preoperative serum UA levels and post-donation long-term events and renal function. Methods This was a single-center retrospective analysis of 183 living kidney donors. The donors were divided into high (≥5.5 mg/dl) and low (

Published
2021
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2. Case Report: Ninjin'yoeito May Improve Quality of Life After Hospitalization for Acute Illness in Patients With Frailty

Author

Masayuki Kashima

Subjects
ninjin'yoeito, quality of life, acute illness, frailty, hospitalization, Nutrition. Foods and food supply, TX341-641
Abstract

Introduction: Frail patients are susceptible to a large number of diseases, and frailty particularly is known to develop after acute illness. No conventional drugs are known to prevent such exacerbation after acute illness. However, traditional Japanese medicine, Kampo, is thought to confer efficacious energy and nutritional supplements and serve to improve malaise after acute illness. Ninjin'yoeito is a representative Kampo medicine for such situation.Cases: We describe three frail patients hospitalized for acute illness who started taking ninjin'yoeito at the time of discharge.Case 1: An 87-year-old man admitted with acute prostatitis complicated by hypertension and chronic obstructive pulmonary disease (COPD). His 36-Item Short Form Health Survey (SF-36) score, which is representative of total quality of life and comprises eight components, showed consistent improvements after 4 and 12 weeks of ninjin'yoeito administration, especially for body pain (BP; scores from 41 to 51 and 100, respectively), social function (SF; 50, 100, 100), and mental health (MH; 75, 75, 90).Case 2: A 65-year-old man admitted with urinary tract infection complicated by primary sclerosing cholangitis and COPD. All SF-36 component scores showed improvement 12 weeks later: physical function (PF; 70–95), role physical (RP; 75–100), BP (72–84), general health (GH; 45–52), vitality (VT; 37.5–75), SF 75–100, role emotional (RE; 75–100), and MH (70–90).Case 3: An 80-year-old man admitted for pneumonia complicated with hypertension. SF-36 score was improved 4 weeks later for RP (68.8–100), BP (52–61), GH (52–72), VT (43.8–62.5), SF (37.5–100), and RE (58.3–91.7).Conclusion: Patients with frailty often have a worsened SF-36 score after discharge following acute illness, but the score may be improved by taking ninjin'yoeito.

Published
2021
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5. Role of ICAM-1 in the aggregation and adhesion of human alveolar macrophages in response to TNF-α and INF-γ

Author

Masahiro Sasaki, Yuriko Namioka, Takefumi Ito, Noriko Izumiyama, Shin Fukui, Akiko Watanabe, Masayuki Kashima, Masaaki Sano, Takanobu Shioya, and Mamoru Miura

Subjects
Pathology, RB1-214
Abstract

Intracellular adhesion molecule-1 (ICAM-1)-mediated cell-cell adhesion is thought to play an important role at sites of inflammation. Recent evidence suggests that ICAM-1 surface expression on alveolar macrophages is increased in pulmonary sarcoidosis and that inflammatory granuloma formation is characterized by the aggregation of macrophages. The present study shows that ICAM-1 expression is significantly elevated on alveolar macrophages from patients with sarcoidosis in response to tumor necrosis factor-α (TNF-α) and interferon- γ (INF-γ) compared with healthy controls. Aggregation and adhesion were significantly increased in alveolar macrophages treated with TNF-α and INF-γ, and significantly inhibited in those pretreated with a monoclonal antibody to ICAM-1. Similarly, aggregation and adhesion were inhibited in macrophages treated with heparin, which then exhibited a wide range of biological activities relevant to inflammation. These results suggested that the surface expression of ICAM-1 on alveolar macrophages in response to TNF-α and INF-γ is important in mediating aggregation and adhesion. Additionally, heparin may be useful for developing novel therapeutic agents for fibrotic lung disease.

Published
2001
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6. Erythromycin and clarithromycin modulation of growth factor-induced expression of heparanase mRNA on human lung cancer cells in vitro

Author

Masahiro Sasaki, Takefumi Ito, Masayuki Kashima, Shin Fukui, Noriko Izumiyama, Akiko Watanabe, Masaaki Sano, Yosimasa Fujiwara, and Mamoru Miura

Subjects
Pathology, RB1-214
Abstract

Heparanase activity is correlated with the metastatic potential of several cancer cells and is a key enzyme in the breakdown of tissue barriers. It is also involved in the regulation of growth factor and cytokine activity. However, little is known about the factors that induce heparanase in cancer cells. We investigated the effect of three growth factors, plateletderived growth factor (PDGF), hepatocyte growth factor (HGF) and basic fibroblast growth factor (bFGF), on heparanase mRNA induction in lung cancer cells in vitro. In addition, we examined the effect of erythromycin (EM) and clarithromycin (CAM), which are 14-membered ring macrolide antibiotics that act as biological response modifiers, on the expression of heparanase mRNA induced by growth factors.

Published
2001
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7. Effect of suplatast tosilate on cough variant asthma

Author

Takanobu Shioya, Manabu Kagaya, Masaaki Sano, Takeshi Ito, Tsutomu Shindo, Masayuki Kashima, Akiko Watanabe, Kazuhiro Sato, Nobuaki Ito, Masahiro Sasaki, and Mamoru Miura

Subjects
asthma, capsaicin, cough threshold, cough variant asthma, eosinophilic cationic protein, suplatast, T helper 2 cell-derived cytokine inhibitor, Immunologic diseases. Allergy, RC581-607
Abstract

A 40-year-old female patient with chronic persistent cough was diagnosed with cough variant asthma (CVA). To investigate the effect of suplatast tosilate (suplatast, 300 mg/day, three times a day), cough scores, medication scores, pulmonary function, capsaicin cough threshold, bronchial hyperresponsiveness (BHR) to methacholine and eosinophilic cationic protein (ECP) concentration in hypertonic saline-induced sputum were evaluated before and after a 6-week treatment with suplatast. Treatment with suplatast resulted in a marked decrease in persistent cough and in the percentage of eosinophils and ECP concentration in induced sputum. It also resulted in a marked improvement in capsaicin cough threshold and a slight improvement in BHR. These results suggest that suplatast tosilate may be useful for treating patients with CVA.

Published
2000
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8. Effect of heparin and related glycosaminoglycan on PDGF-induced lung fibroblast proliferation, chemotactic response and matrix metalloproteinases activity

Author

Masahiro Sasaki, Masayuki Kashima, Takefumi Ito, Akiko Watanabe, Masaaki Sano, Manabu Kagaya, Takanobu Shioya, and Mamoru Miura

Subjects
Pathology, RB1-214
Abstract

Fibroblast migration, proliferation, extacellular matrix protein synthesis and degradation are the key events in various biological and pathological processes in pulmonary fibrosis. In addition, biopsy specimens from the lungs of patients with plumomary fibrosis show increased numbers of mast cells which have metachromatic granules containing heparin, histamin and proteases. Little is known about how these products influence pulmonary fibrosis. In the present study, we investigated the effect of heparin and related glycosaminoglycans on PDGF-induced lung fibroblast proliferation and chemotactic response in vitro. In addition, we examined the effect of heparin on both the induction of matorix metalloproteinases (MMPs) and MMPs activity in lung fibroblasts in vitro.

Published
2000
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9. Differential regulation of metalloproteinase production, proliferation and chemotaxis of human lung fibroblasts by PDGF, Interleukin-1β and TNF-α

Author

Masahiro Sasaki, Masayuki Kashima, Takefumi Ito, Akiko Watanabe, Noriko Izumiyama, Masaaki Sano, Manabu Kagaya, Takanobu Shioya, and Mamoru Miura

Subjects
Pathology, RB1-214
Abstract

Fibroblast migration, proliferation, extracellular matrix protein synthesis and degradation,all of which play important roles in inflammation, are them selves induced by various growth factors and cytokines. Less is known about the interaction of these substances on lung fibroblast function in pulmonary fibrosis.

Published
2000
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17. Wernicke encephalopathy: limitations in a laboratory and radiological diagnosis.

Author

Kohei Ono, Satoshi Hayano, and Masayuki Kashima

Abstract

Wernicke encephalopathy is an emergent neurological disorder caused by vitamin B1 (thiamine) deficiency. Here, we present a case of Wernicke encephalopathy in a male patient in his 70s with normal serum thiamine levels and MRI findings on admission. He had a history of heavy alcohol consumption and a gradual decrease in food intake. On arrival at the hospital, his consciousness was impaired which persisted even after glucose replacement. Moreover, horizontal nystagmus and cerebellar ataxia were observed. Head CT scan and MRI revealed no abnormal findings. Further, his serum thiamine level was within the normal range. The patient was clinically diagnosed with Wernicke encephalopathy, and high-dose thiamine therapy was started. Then, his symptoms improved immediately. Thus, in case of clinical suspicion, treatment for Wernicke encephalopathy must be initiated promptly even in patients with normal serum thiamine levels. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Conventional and Kampo medicine in the treatment of mild to moderate COVID‐19: A multicenter, retrospective observational study protocol by the Integrative Management in Japan for Epidemic Disease ( <scp>IMJEDI study‐Observation</scp> )

Author

Tomoko Suzuki, Natsumi Saito, Tetsuhiro Yoshino, Sadahiro Sempuku, Rie Katori, Takuhiro Yamaguchi, Masayuki Kashima, Akihiko Kashio, Mahiko Nagase, Eiichi Tahara, Mosaburo Kainuma, Kotaro Nochioka, Susumu Fujii, Norio Suda, Seiichi Kobayashi, Satoko Minakawa, Tadamichi Mitsuma, Yutaka Tanaka, Masaru Mimura, Tadashi Ishii, Shih-Wei Chiu, Hajime Nakae, Toshiaki Saito, Yasuhito Irie, Mayuko Yamazaki, Shigeki Chiba, Shuichi Abe, Ryutaro Arita, Takashi Ito, Hirofumi Maehara, Shin Takayama, Fumihiro Saitoh, Kayo Nakamoto, Rie Ono, Tatsuya Ishige, Takao Namiki, Sayaka Koizumi, Tatsuya Nogami, Akiko Kikuchi, Kenichi Yokota, Hiroki Kai, Koichiro Tanaka, Yoshinobu Nakada, Hiroko Sato, Osamu Shimooki, Tomoaki Ishigami, and Takuya Masuda

Subjects
Pediatrics, medicine.medical_specialty, business.industry, Kampo, Retrospective cohort study, Disease, medicine.disease, Diarrhea, Informed consent, Severity of illness, medicine, Dementia, Sputum, medicine.symptom, business
Abstract

Aim: We present the study protocol of a multicenter, retrospective observational study that aims to investigate the efficacy of the actual treatment (the efficacy of conventional and Kampo medicines) of patients with mild to moderate or suspected coronavirus disease (COVID-19) Methods: This study is designed as a multicenter, retrospective observational study Outpatients and inpatients will be recruited from Japanese hospitals The inclusion criteria are as follows: having or suspected to have COVID-19, mild to moderate COVID-19, symptomatic, ≥20 years of age, male or female, able to communicate in Japanese, and treated with conventional and Kampo medicine The exclusion criteria are: unable to provide informed consent due to dementia, psychosis, or psychiatric symptoms, severe COVID-19, or determined unsuitable for this study The sample size is set at 1000, as this number of people can be treated at the collaborating medical institutions during the study period Results: The main outcome is the number of days without fever, with a body temperature of less than 37°C The secondary outcome is set at common cold-like symptoms other than fever (fatigue, cough, shortness of breath, sputum, diarrhea) and severity of illness and hospitalization up to 14 days after the visit Trial registration: The trial was registered in the University Hospital Medical Information Network (Reservation No UMIN000041301) on August 4, 2020 Conclusion: Our study will explore the contribution of conventional and Kampo medicine in the treatment of patients with mild and moderate COVID-19

Published
2020
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31. Is the Living Donor Kidney Profile Index Valuable in Japanese Patients?

Author

Akito Inadome, Masayuki Kashima, Soichi Uekihara, Hiroshi Yokomizo, Masatomo Ogata, Chiaki Kawabata, Akari Kaba, Yuji Hidaka, Kosuke Tanaka, Kenji Okumura, Mariko Toyoda, Kohei Kinoshita, Akira Miyata, Shigeyoshi Yamanaga, and Mika Fujii

Subjects
Male, medicine.medical_specialty, Population, Renal function, Kidney Function Tests, Severity of Illness Index, Japan, Interquartile range, Internal medicine, Living Donors, medicine, Humans, education, Survival rate, Aged, Retrospective Studies, Transplantation, education.field_of_study, business.industry, Incidence (epidemiology), Graft Survival, Area under the curve, Middle Aged, medicine.disease, Kidney Transplantation, United States, Survival Rate, Area Under Curve, Female, Surgery, business, Body mass index, Kidney disease
Abstract

Introduction The Living Kidney Donor Profile Index (LKDPI) was recently proposed in the United States to evaluate living donor quality. Japan has a largely different renal transplant circumstance, such as a high ABO incompatibility rate. The aim of this study was to validate the LKDPI among the Japanese population and adjust the score. Methods We performed a retrospective analysis of 133 living donors in renal transplant in our institution. We analyzed the clinical characteristics and outcomes, and created a modified LKDPI score considering the favorable ABO incompatible kidney transplant outcomes in Japan. Results Median (interquartile range [IQR]) donor age was 59 (51 to 65) and median (IQR) body mass index was 22.9 kg/m2 (20.9 to 25.2). ABO incompatibility rate was 28.5%. Median (IQR) donor estimated glomerular filtration rate (eGFR) (Chronic Kidney Disease Epidemiology Collaboration equation) was 108.7 mL/min/1.73 m2 (99.9 to 115.5). The 1-year graft survival rate was 98.5%, and the 3-year graft survival rate was 97%. The incidence of antibody mediated rejection was 5.2%. The median (IQR) LKDPI score was 30.2 (11.8 to 46.8). This was significantly higher than the previously reported score in the United States, which was 12.8 (-0.8 to 27.2). The modified LKDPI (mLKDPI) score was 23.2 (4.1 to 35.1). LKDPI and mLKDPI did not show a diagnostic value in graft survival; however, LKDPI and mLKDPI showed significant diagnostic value in eGFR at 1 year (area under the curve [AUC]=0.627, P = .017; and AUC=0.673, P = .01). Conclusion Our outcomes had better survival even though with higher ABO incompatibility rate. According to original LKDPI, our donor pool is higher than the general US population. In this study, lower LKDPI tended to be associated with good allograft function, and mLKDPI has better diagnostic value than LKDPI. To compare internationally, an adjusted model for Japan might be necessary based on the outcomes of a large population.

Published
2020
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32. Acute Dacryoadenitis due to Primary Epstein-Barr Virus Infection

Author

Satoshi Hayano, Naruhiko Nakada, and Masayuki Kashima

Subjects
Infectious Diseases, Oncology, hemic and lymphatic diseases
Abstract

We herein present the case of a 28-year-old male patient who presented with fever and bilateral upper eyelid edema without other upper airway symptoms and was diagnosed with acute dacryoadenitis due to Epstein-Barr virus (EBV) infection. The patient’s medical history was unremarkable. Laboratory tests revealed lymphocytosis with atypical lymphocytes and abnormal liver function tests. Physical examination and computed tomography revealed swelling in the lacrimal glands, and serological tests confirmed EBV infection. Although rare, ocular symptoms of primary EBV infection are important for diagnosis. Acute dacryoadenitis should be considered as a rare manifestation and an underdiagnosed complication of primary EBV infection.

Published
2022
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37. Update of Internal Medicine

Author

Mikiko Ozaki, Keiko Hayano, Shumpei Yoshino, Seiko Fujimoto, Masayuki Kashima, Junichi Taniguchi, and Kazuhiro Takahashi

Subjects
medicine.medical_specialty, business.industry, Medicine, Medical physics, General Medicine, business
Published
2019
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38. Photobacterium damselae subsp. damselae bacteraemia in a patient with liver cirrhosis

Author

Satoshi Hayano, Takayuki Masaki, Masayuki Kashima, and Risako Tadakuma

Subjects
0301 basic medicine, Cirrhosis, biology, medicine.diagnostic_test, business.industry, fungi, 030106 microbiology, Ceftazidime, Case Report, General Medicine, medicine.disease, Photobacterium, biology.organism_classification, Microbiology, 03 medical and health sciences, 030104 developmental biology, Photobacterium damselae, Vibrionaceae, Cellulitis, Bacteremia, medicine, Blood culture, business, medicine.drug
Abstract

Photobacterium damselaesubsp.damselaeis a family ofVibrionaceaeand exists in the marine environment. The organism rarely causes soft-tissue infection in humans; moreover, most of the infected individuals have a history of fishing or exposure to brackish water. We experienced the case of a 63-year-old patient with a history of liver cirrhosis (Child-Pugh class B) who presented with a fever and swelling of the left leg with pain. His symptoms developed after fishing and eating raw fish with exposure of brackish water. He was diagnosed with cellulitis, andPhotobacterium damselaespp.damselaewas detected in blood culture. The patient was treated with ceftazidime and minocycline and he was discharged after recovery. We need to be aware that in immunocompromised patients with cellulitis exposed to brackish water, organisms other thanStaphylococciandStreptococcimay be the causative organisms.

Published
2021

39. Long-term impact of baseline serum uric acid levels on living kidney donors: a retrospective study

Author

Akari Kaba, Mariko Toyoda, Hiroshi Yokomizo, Sho Nishida, Shigeyoshi Yamanaga, Toshinori Ishizuka, Yuji Hidaka, Kohei Kinoshita, Akira Miyata, Masayuki Kashima, Chiaki Kawabata, Satoshi Hamanoue, Kenji Okumura, and Kosuke Tanaka

Subjects
Nephrology, Male, medicine.medical_specialty, Time Factors, Renal function, lcsh:RC870-923, Gastroenterology, Donor Selection, chemistry.chemical_compound, Serum uric acid, Living kidney donors, Diabetes mellitus, Internal medicine, medicine, Living Donors, Humans, Adverse effect, Aged, Retrospective Studies, business.industry, Donor selection, Middle Aged, lcsh:Diseases of the genitourinary system. Urology, medicine.disease, Kidney Transplantation, Gout, Uric Acid, Treatment Outcome, chemistry, Adverse events, Preoperative Period, Uric acid, Female, business, Dyslipidemia, Research Article
Abstract

BackgroundPreoperative characteristics of living kidney donors are commonly considered during donor selection and postoperative follow-up. However, the impact of preoperative uric acid (UA) levels is poorly documented. The aim of this study was to evaluate the association between preoperative serum UA levels and post-donation long-term events and renal function.MethodsThis was a single-center retrospective analysis of 183 living kidney donors. The donors were divided into high (≥5.5 mg/dl) and low (ResultsIn total, 44 donors experienced 52 adverse events over 5 years. The incidence of adverse events within 5 years was significantly higher in the high UA group than in the low UA group (50% vs. 24%,p = 0.003); this was true even after the exclusion of hyperuricemia-related events (p = 0.047). UA emerged as an independent risk factor for adverse events (p = 0.012). Donors with higher UA levels had lower eGFRs after donation, whereas body mass index, hemoglobin A1c, blood pressure, and low-density lipoprotein cholesterol did not have any impact on the eGFR.ConclusionsThe findings suggest that preoperative UA levels should be considered during donor selection and postoperative follow-up.

Published
2021

41. Multimode-based polarization independent WDM devices using different order modes for TE and TM polarizations

Author

Masayuki Kashima, Hironori Sasaki, Hiroki Yaegashi, Hideaki Okayama, Yosuke Onawa, and Daisuke Shimura

Subjects
Physics, Multi-mode optical fiber, business.industry, Physics::Optics, 02 engineering and technology, 021001 nanoscience & nanotechnology, Mach–Zehnder interferometer, Polarization (waves), 01 natural sciences, Atomic and Molecular Physics, and Optics, 010309 optics, Interferometry, Optics, Band-pass filter, Fiber Bragg grating, 0103 physical sciences, Mode coupling, Power dividers and directional couplers, 0210 nano-technology, business
Abstract

Multimode based polarization independent (PI) wavelength division multiplexing (WDM) devices are proposed and experimentally demonstrated. The key concept is to utilize two different order modes for the orthogonal polarizations, ith-order mode for TE and jth-order mode for TM (i ≠ j) polarization respectively to extend the flexibility for designing devices. PI coupler composed of a multimode directional coupler and mode converters is introduced as a basic device. Then, we apply PI coupler to Mach Zehnder interferometer (MZI) and Bragg grating bandpass filters. PI MZI is achieved by optimizing the combination of two phase shifters in the interferometer arms. PI bandpass uses 3dB-PI coupler and polarization rotate Bragg gratings that induce mode coupling between the polarizations. Each device showed good matching in the spectrum between TE and TM polarizations in term of operation wavelength. The proposed concept can be a promising approach to realize PI WDM functions without introducing polarization diversity scheme in which a polarization beam splitter, two devices designed for each polarization and a polarization beam combiner are required.

Published
2020

42. Optimizing functional split of baseband processing on TWDM-PON based fronthaul network

Author

Masayuki Murata, Masayuki Kashima, Yoshihiro Nakahira, Shingo Ata, and Go Hasegawa

Subjects
Optimization problem, business.industry, Computer science, 05 social sciences, Latency (audio), 050801 communication & media studies, 020206 networking & telecommunications, 02 engineering and technology, Passive optical network, 0508 media and communications, Wavelength-division multiplexing, Server, 0202 electrical engineering, electronic engineering, information engineering, Baseband, business, 5G, Computer network, Efficient energy use
Abstract

One of the major shortcomings of Centralized Radio Access Networks (C-RAN) is that the large capacity is required for fronthaul network between Remote Radio Heads (RRHs) and central office with baseband unit (BBU) pool. Possible solutions are to introduce lower-cost networking technology for fronthaul network, such as Time and Wavelength Division Multiplexing Passive Optical Network (TWDM-PON), and to introduce functional split, that moves some baseband processing functions to cell site to decrease the utilization of the fronthaul network. In this paper, we construct the mathematical model for selecting function split options of baseband processing to minimize the power consumption of TWDM-PON based fronthaul network. In detail, we formulate the optimization problem for minimizing the total power consumption of fronthaul network in terms of the capacity of TWDM-PON, the number of RRHs in each cell site, server resources, latency constraints, the amount of traffic from each RRH, physical/virtual server power consumption characteristics. Numerical examples are shown for confirming the correctness of the proposed model and for presenting the effect of resource enhancement methods on the capacity and energy efficiency of the system.

Published
2020
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43. Optimizing Intraoperative Blood Pressure to Improve Outcomes in Living Donor Renal Transplantation

Author

Kosuke Tanaka, Masayuki Kashima, Akito Inadome, Hiroshi Yokomizo, Chiaki Kawabata, Mariko Toyoda, Masatomo Ogata, Kohei Kinoshita, Shigeyoshi Yamanaga, Mika Fujii, Akari Kaba, Soichi Uekihara, Takaaki Kobayashi, Yuji Hidaka, and Akira Miyata

Subjects
Adult, Male, Cardiac output, medicine.medical_specialty, Central Venous Pressure, medicine.medical_treatment, Cardiac index, Renal function, Blood Pressure, Kidney, Cohort Studies, Renal Dialysis, Internal medicine, medicine, Living Donors, Humans, Dialysis, Retrospective Studies, Transplantation, Intraoperative Care, business.industry, Central venous pressure, Stroke volume, Middle Aged, Kidney Transplantation, Blood pressure, Treatment Outcome, Reperfusion, Cardiology, Surgery, Female, business, Glomerular Filtration Rate
Abstract

BACKGROUND Adequate renal perfusion at the time of unclamping is important because it has been known to affect outcomes in renal transplantation. Nevertheless, the ideal intraoperative systolic arterial pressure (SAP) has not been well defined. METHODS We performed a retrospective analysis of 106 living donor renal transplants performed at our center from June 2010 to May 2019. We divided the cohort into 2 groups according to our center's goal SAP of ≥150 mm Hg: 57 patients had SAP ≥150 mm Hg and 49 patients had SAP

Published
2019

44. Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial

Author

Ruilope, Luis M, Agarwal, Rajiv, Anker, Stefan D, Bakris, George L, Filippatos, Gerasimos, Nowack, Christina, Kolkhof, Peter, Joseph, Amer, Mentenich, Nicole, Pitt, Bertram, Diego, Besada, Alfredo, Wassermann, Julio, Bittar, Alicia, Elbert, Augusto, Vallejos, Gloria, Viñes, Hugo, Sanabria, Federico Pérez Manghi, Alberto, Liberman, Inés, Bartolacci, Diego, Aizenberg, Mariano, Chahin, Laura, Maffei, Elizabeth, Gelersztein, Bernhard, Ludvik, Hans-Robert, Schönherr, Heinz, Drexel, Wolfgang, Preiß, Ursula, Hanusch, Peter, Neudorfer, Friedrich, Prischl, Bernhard, Paulweber, Christoph, Ebenbichler, Rudolf, Prager, Harald, Sourij, Gerit-Holger, Schernthaner, Martin, Clodi, Evelyn, Fliesser-Görzer, Elif, Ekinci, Richard, Macisaac, David, Packham, Hugo, Stephenson, Michael, Suranyi, Gary, Wittert, Katie-Jane, Wynne, Alexia, Pape, Duncan, Topliss, Peter, Colman, Craig, Nelson, James, Vandeleur, David, Colquhoun, Simon, Roger, Peak Mann Mah, Walter, Abhayaratna, Luc VAN Gaal, Pieter, Gillard, Jean-Michel, Hougardy, Marijn, Speeckaert, Koen, Stas, Wendy, Engelen, Francis, Duyck, André, Scheen, Hilde, Vanbelleghem, Peter, Doubel, Svetla, Vasileva, Rosen, Rashkov, Boyan, Nonchev, Theodora, Temelkova-Kurktschieva, Mariana, Yoncheva-Mihaylova, Rangel, Rangelov, Neli, Klyuchkova, Pavel, Stanchev, Zhivko, Tagarev, Radostina, Boshnyashka, Petya, Manova, Zhulieta, Prakova, Mariya, Lucheva, Valentina, Gushterova, Ghassan, Farah, Dimitar, Georgiev, Mariyana, Pichmanova, Dotska, Minkova, Bilyana, Stoyanovska-Elencheva, Maria Eugenia Canziani, Miguel, Hissa, Irene, Noronha, Joao Eduardo Salles, Daniela, Antunes, Freddy, Eliaschewitz, Carlos Eduardo Figueiredo, Rogerio de Paula, Luis, Canani, Maurilo Leite Jr, Bruno, Paolino, Rosangela, Rea, Sergio, Vencio, Claudia, Brito, Raphael, Paschoalin, Roberto Pecoits Filho, Eduardo, Vasconcellos, Nathalia, Paschoalin, Adriana, Forti, Roberto, Botelho, Miguel, Riella, Dalton, Precoma, Maria, Cerqueira, Lilia, Maia, Evandro, Portes, Marcio, Pereira, Joanne, Liutkus, Dennis, O Keefe, Richard, Tytus, Brian, Carlson, James, Conway, Michael, Walsh, Igor, Wilderman, Andrew, Steele, Sheldon, Tobe, Louise, Vitou, Karthik, Tennankore, Valdemar, Martinho, Philip, Mcfarlane, Daniel, Shu, Serge, Cournoyer, Richard, Dumas, Giuseppe, Mazza, Guy, Tellier, George, Tsoukas, Stanley, Weisnagel, Jean-Francois, Yale, Sameh, Fikry, Randolph, Hart, Pavel, Hamet, Francois, Madore, Paul, Barre, Daniel, Schwartz, Allan, Kelly, Ivor, Teitelbaum, Sean, Peterson, Sam, Henein, Richard, Goluch, Gregoire, Wuerzner, Markus, Laimer, Stefan, Bilz, Marc, Donath, Gottfried, Rudofsky, Christopher, Strey, Antoinette, Pechère-Bertschi, Paola, Varleta, Fernando, González, Marcelo, Medina, Carmen, Romero, Victor, Saavedra, Juan Carlos Prieto, Eliana, Reyes, Juan Carlos Palma, Jorge, Cobos, Zhihong, Liu, Dalong, Zhu, Nan, Chen, Fang, Liu, Wang, Li, Qing, Su, Bingyin, Shi, Aiping, Yin, Hao, Wang, Yan, Li, Jianying, Niu, Chaoqing, Wu, Xinjun, Wang, Ying, Zhang, Peng, Ai, Jianhua, Ma, Yuxiu, Li, Hongguang, Zheng, Minxiang, Lei, Zhaohui, Mo, Nanwei, Tong, Jinluo, Cheng, Youping, Dong, Xudong, Xu, Qinkai, Chen, Tianjun, Guan, Gang, Long, Changying, Xing, Ling, Li, Yinghong, Liu, Hao, Zhang, Ling, Zhong, Zhonghe, Li, Longyi, Zeng, Jiali, Wei, Hanqing, Cai, Tianfeng, Wu, Weiping, Lu, Ning, Xu, Yibing, Lu, Dejun, Chen, Ruifang, Bu, Jiansong, Shen, Junwu, Dong, Zhiquan, Zhao, Fei, Xiong, Fangfang, Jiang, Jinkui, Yang, Jian, Kuang, Guoyuan, Lu, Lihua, Wang, Yanlin, Zhang, Shuifu, Tang, Weiying, Guo, Jian, Liu, Sheng, Jiang, Fang, Yi, Yuming, Du, Zhuxing, Sun, Yuantao, Liu, Liyong, Zhong, Dongmei, Li, Hongmei, Li, Chuanming, Hao, Feixia, Shen, Jianqin, Wang, Jingmei, Li, Dora, Molina, Carlos, Cure, Jaime, Ibarra, Gustavo, Aroca, Hernán, Yupanqui, Eric, Hernández, Mónica, López, Gregorio, Sánchez, Germán, Barreto, Edgar, Arcos, Miguel, Urina, William, Kattah, Carlos, Durán, Clara, Arango, Julian, Coronel, Guillermo, Blanco, Mónica, Terront, Gustavo, 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Kashima, Fumiko, Yamakawa, Shuji, Horinouchi, Hirofumi, Imoto, Hiroshi, Sobajima, Hidetoshi, Kanai, Naoki, Matsuoka, Hirotaka, Shibata, Akemi, Inagaki, Toshiyuki, Sugiura, Toru, Sugiyama, Hidekatsu, Yanai, Yoshiyuki, Hamamoto, Masahiro, Hatazaki, Terumasa, Hayashi, Kunihisa, Kobayashi, Satoshi, Murao, Makoto, Ujihara, Kazuya, Sugitatsu, Katsunori, Kawamitsu, Ken, Yamakawa, Izumi, Tsunematsu, Fumi, Kikuchi, Hideaki, Jinnouchi, Tetsuyuki, Yasuda, Hajime, Maeda, Yasuto, Matsuo, Hideki, Okamoto, Takeshi, Katsuki, Ken, Yajima, Takeshi, Morita, Masayuki, Inagaki, Wooje, Lee, Jungoo, Kang, Cheol Young Park, Hyesoon, Kim, Singon, Kim, Youcheol, Hwang, Injoo, Kim, Jaehyeon, Kim, Young Min Cho, Byungwan, Lee, Choonhee, Chung, Soo, Lim, Jae Myung Yu, Dovile, Kriauciuniene, Antanas, Navickas, Audrone, Velaviciene, Egle, Urbanaviciene, Gediminas, Urbonas, Jurate, Lasiene, Lina, Radzeviciene, Ron, Gansevoort, Adriaan, Kooy, G Lieverse, A, L Penne, E, Ruud J, M van Leendert, M van Buren, H Boonstra, A, C Bakker, R, Marielle, Krekels, B Brouwer, C, T Luik, P, J N, M Barendregt, Bert-Jan van den Born, Trine, Finnes, Thomas, Karlsson, Hilde, Selsås, Emil, Asprusten, Robert, Hagemeier, Erik, Eriksen, Knut, Risberg, Hans, Høivik, Leidulv, Solnør, Frode, Thorup, Jan, Rocke, Rick, Cutfield, Peter, Dunn, Jeremy, Krebs, Russell, Scott, Kingsley, Nirmalaraj, Nine, Smuts, John, Baker, Veronica, Crawford, Albert, Bautista, Roberto, Mirasol, Elizabeth, Catindig, Glenda, Pamugas, Louie, Tirador, Maribel, Tanque, Janusz, Gumprecht, Piotr, Napora, Edward, Franek, Andrzej, Stankiewicz, Katarzyna, Landa, Agnieszka, Tiuryn-Petrulewicz, Kazimierz, Ciechanowski, Bogna, Wierusz-Wysocka, Barbara, Rewerska, Grazyna, Cieslik, Michal, Hoffmann, Michal, Nowicki, Jolanta, Krzykowska, Stanislaw, Mazur, Katarzyna, Wasilewska, Anna, Ocicka-Kozakiewicz, Ewa, Skokowska, Renata, Wnetrzak-Michalska, Jan, Ruxer, Patrycja, Butrymowicz, Katarzyna, Madziarska, Ilona, Kurnatowska, Teresa, Rusicka, Adam, Madrzejewski, Tomasz, Stompor, Jose, Guia, Amalia, Pereira, Pedro, Melo, Cristina, Roque, Francisco, Rosario, Fernando Teixeira, E Costa, Fernando, Nolasco, Edgar, Almeida, Pedro, Matos, Cesar, Esteves, Rui, Carvalho, Ilidio, Brandao, Susana, Heitor, Ana Vila Lobos, Rosa, Ballesteros, Gil, Silva, Carlos, Barreto, Ana, Silva, Natalya, Vorokhobina, Alexander, Sherenkov, Ivan, Gordeev, Olga, Semenova, Sergey, Levashov, Vyacheslav, Marasaev, Ruslan, Sardinov, Vadim, Klimontov, Vitaliy, Baranov, Nadezhda, Verlan, Albert, Galyavich, Arkadiy, Demko, Zhanna, Kobalava, Elena, Zakharova, Lyudmila, Kvitkova, Oleg, Solovev, Elena, Smolyarchuk, Larisa, Zhukova, Elena, Zhdanova, Andrey, Babkin, Galina, Nechaeva, Olga, Barbarash, Elena, Rechkova, Roman, Libis, Elena, Kosmacheva, Tatyana, Rodionova, Irina, Ipatko, Alexander, Dreval, Nina, Petunina, Elena, Chernyavskaya, Alsu, Zalevskaya, Yuriy, Khalimov, Tatyana, Zykova, Anton, Edin, Ashot, Mkrtumyan, Shamil, Palyutin, Vyacheslav, Mareev, Leonid, Strongin, Olga, Ukhanova, Mikhail, Antsiferov, Davyd, Yakhontov, Leonid, Pimenov, Natalya, Koziolova, Konstantin, Nikolaev, Imad, Merai, Olga, Zanozina, Leyla, Gaysina, Mikhail, Arkhipov, Natalia, Malykh, Oksana, Rymar, Vladimir, Martynenko, Sofya, Malyutina, Polina, Ermakova, Marina, Kalashnikova, Bengt-Olov, Tengmark, Carl-Johan, Lindholm, Dan, Curiac, Ken, Eliasson, Erik, Rein-Hedin, Gregor, Guron, Inga, Soveri, Annette, Bruchfeld, Jonas, Spaak, Malin, Frank, Magnus, Löndahl, Hans, Larnefeldt, Margareta, Hellgren, Olof, Hellberg, Yong Mong Bee, Chee Fang Sum, Ru San Tan, Piyamitr, Sritara, Chaicharn, Deerochanawong, Chatlert, Pongchaiyakul, Natapong, Kosachunhanan, Bancha, Satirapoj, Ahmet, Temizhan, Ibrahim, Gul, Ramazan, Sari, Aytekin, Oguz, Mustafa, Tigen, Huseyin, Yilmaz, Ozer, Badak, Oner, Ozdogan, Talat, Tavli, Necmi, Eren, Murat, Cayli, Sedat, Ustundag, Yavuz, Yenicerioglu, Ismail, Kocyigit, Abdulbaki, Kumbasar, Idris, Sahin, Lee-Ming, Chuang, Ju-Ying, Jiang, Chien-Te, Lee, Der-Cherng, Tarng, Shih-Te, Tu, Mai-Szu, Wu, Ming-Ju, Wu, Chiz-Tzung, Chang, Cheng-Chieh, Hung, Liubov, Sokolova, Borys, Mankovsky, Dmytro, Kogut, Viktoriia, Chernikova, Kateryna, Malyar, Nonna, Kravchun, Volodymyr, Botsyurko, Vitaliy, Maslyanko, Liliya, Martynyuk, Oleksandr, Serhiyenko, Vasyl, Stryzhak, Halyna, Myshanych, Oleksandra, Donets, Iryna, Bondarets, Maryna, Vlasenko, Nataliia, Pertseva, Mariia, Grachova, Ivan, Smirnov, Larysa, Pererva, Ivan, Fushtey, Julia, Komisarenko, Anna, Isayeva, Carl, Meisner, Bobby, Khan, Louis, Maletz, Bradley, Dixon, Ahmed, Arif, Timothy, Jackson, Mirela, Ponduchi, Mahfouz El Shahawy, Salil, Nadkarni, Daniel, Urbach, Jorge, Paoli-Bruno, Henry, Lora, Umar, Farooq, Steven, Zeig, Lance, Rudolph, Nabil, Andrawis, William, Kaye, Jill, Meyer, Khalid, Bashir, Glenn, Heigerick, James, Smelser, Javier Ricardo Colomar, David, Scott, Brian, First, Stuart, Handelsman, Jose, Bautista, Rajesh, Patel, Stephen, Minton, Juan, Frias, Luis, Ramos-Gonez, John, Bertsch, Ali, Iranmanesh, Vivian, Fonseca, Michael, Yuryev, Larry, Popeil, Jose, Cardona, Sanjeev, Saxena, Santosh, Sharma, Edgar, Gonzalez, Richard, Solomon, Muhammad, Khan, Ahmed, Awad, David, Fitz-Patrick, Douglas, Linfert, David, Grant, Susan, Brian, Leon, Fogelfeld, Rafael, Canadas, Pablo, Pergola, Joseph, Soufer, Rakesh, Patel, Shujauddin, Valika, Jonathan, Winston, Allison, D, Maria, Caramori, Stanley, Koch, Anjay, Rastogi, Jonathan, Bornfreund, Michael, Rocco, Maxine, Hamilton, Luis, Garcia-Mayol, Peter, Weissman, Suzanne, Oparil, Gary, Ruoff, Kyaw, Soe, Gary, Korff, Robert, Busch, Alexander, Lurie, Israel, Hartman, Garfield, Samuels, Derek, Lejeune, Visal, Numrungroad, Stephen, Brietzke, Zeid, Kayali, Harold, Szerlip, Steven, Barag, Gilberto, Seco, Damaris, Vega, Osvaldo, Brusco, Camil, Kreit, Humberto, Cruz, Bharat, Mocherla, Sharma, Prabhakar, George, Fadda, Martin, Valdes, Eugene, Soroka, Ramin, Berenji, Sreedhara, Alla, Shweta, Bansal, Odugbesan, A, Karlton, Pettis, Masoud, Azizad, Idalia, Acosta, Atoya, Adams, William, Sanchez, Rosa, Suarez, Efrain, Reisin, Carlos, Herrera, Keung, Lee, Csaba, Kovesdy, Adam, Whaley-Connell, Aldo, Peixoto, Ronald, Mayfield, Mahendra, Jain, Earl, Martin, Paul, Norwood, Jonathan, Wise, Hugo, Romeu, Stephen, Halpern, Mustafa, Mandviwala, Thomas, Turk, Anna, Burgner, David, Bleich, Ankur, Doshi, Jose, Carpio, Jorge, Posada, Alexander, Magno, Samer, Nakhle, Gary, Goldstein, Caroline, Mbogua, Dierdre, Mcmullen, Dilawar, Ajani, Wayne, Kotzker, Nelson, Kopyt, Richard, Treger, Yusuf, Ruhullah, Sharon, Adler, Harjeet, Brar, Marc, Rendell, Dennis, Ross, Srinivasan, Beddhu, German, Hernandez, Sylvia, Rosas, M Sue Kirkman, Mohammed, El-Shahawy, Jeffrey, Rothman, Ahmad, Barakzoy, Aparna, Tamirisa, Sabrina, Benjamin, Michael, Bahrami, Prabir, Roy-Chaudhury, Ramprasad, Dandillaya, Gretel, Trullenque, Jose, Birriel, John, Flack, Karen, Johnson, Brenda, Lemus, Guillermo, Umpierrez, Geetha, Maddukuri, Kenneth, Jamerson, Christopher, Case, Patrick, Fluck, Saeed, Kronfli, Violet, Habwe, Bala, Subramanian, Tariq, Shafi, Rupesh, Raina, Roland, Fernando, Sourabh, Kharait, Carlos, Hernandez-Cassis, Raymond, Fink, Jamal, Hammoud, Amer, Al-Karadsheh, Manuel, Montero, Philip, Nicol, Jesus, Navarro, Michael, Shanik, Zia, Din, Francisco, Gonzalez-Abreu, Sam, Lerman, Claude, Galphin, John, Evans, Ashwini, Gore, Radica, Alicic, Mandeep, Sahani, Roberto, Pisoni, Tuan-Huy, Tran, Jeffrey, Ryu, Harvey, Serota, Nilda, Neyra, Richard, O Donovan, Sreedhar, Mandayam, Moustafa, Moustafa, Mark, Smith, Arvind, Krishna, Arjun, Sinha, Anuj, Bhargava, Kodangudi, Ramanathan, Soni, Dhanireddy, Stephen, Thomson, Romanita, Nica, Emaad, Abdel-Rahman, Mark, Barney, Mariana, Markell, Nauman, Shahid, David, Oliver, Tran, Khanh, Pham Nguyen Son, Lam VAN Hoang, Boi Ngoc Nguyen, Nguyen Minh Nui, Lan Phuong Tran, Fayzal, Ahmed, Dorothea, Urbach, Dirkie Jansen van Rensburg, Gracjan, Podgorski, Aslam, Amod, Sindeep, Bhana, Shaifali, Joshi, Essack, Mitha, Deepak, Lakha, Louis van Zyl, Trokis, J, Naresh, Ranjith, Mary, Seeber, Mohamed, Sarvan, Mohammed, Tayob, Brian, Rayner, Larry, Distiller, Heidi, Siebert, Mukesh, Joshi, Paul, Rheeder, Magdalena Madero Rovalo, Gustavo Solache Ortiz, Gustavo Méndez Machado, Rafael Valdez Ortiz, Juan Villagordoa Mesa, Saúl Irizar Santana, Sandro Avila Pardo, Jorge Escobedo de la Peña, Guillermo González Gálvez, Leobardo Sauque Reyna, Miriam Bastidas Adrian, Guillermo Fanghänel Salmón, Ramiro Gutiérrez Ochoa, Luis Nevarez Ruiz, Gabriel Ramos López, Alfredo Chew Wong, Arturo Saldaña Mendoza, Pedro García Hernández, José González González, Melchor Alpizar Salazar, José Lazcano Soto, Amaury, Roman-Miranda, Gregorio, Cortes-Maisonet, Liana, Turcu, Adriana, Dumitrescu, Gabriela, Radulian, Hortensia, Barbonta, Cristina, Mistodie, Georgeta, Vacaru, Alexandrina, Popescu, Adrian, Vlad, Silvia, Paveliu, Nicoleta, Mindrescu, Adrian, Albota, Ella, Pintilei, Lavinia, Pop, Gabriela, Negrisanu, Doina, Catrinoiu, Cornelia, Bala, Amorin, Popa, Iosif, Szilagyi, Ciprian, Constantin, Elena, Caceaune, Adriana, Onaca, Li Yuan Lee, Nor Azizah Aziz, Wan Mohd Izani Wan Mohamed, Wan Hasnul Halimi Bin Wan Hasan, Jeyakantha, Ratnasingam, Nik Nur Fatnoon Nik Ahmad, Rizmy Najme Khir, Norhaliza Mohd Ali, Masni, Mohamad, Chek Loong Loh, Joe, Eustace, John, Holian, Donal, Reddan, Yvonne, O Meara, Mensud, Hatunic, Zuzana, Ochodnicka, Dalibor, Sosovec, Andrej, Dzupina, Ingrid, Buganova, Jana, Babikova, Denisa, Spodniakova, Ruilope, L, Agarwal, R, Anker, S, Bakris, G, Filippatos, G, Nowack, C, Kolkhof, P, Joseph, A, Mentenich, N, Pitt, B, Trevisan, R, Pathology/molecular and cellular medicine, Diabetes Pathology & Therapy, and Diabetes Clinic

Subjects
Male, Endocrinology, Diabetes and Metabolism, Enfermedad cardiovascular, 030232 urology & nephrology, BAY 94-8862, Type 2 diabetes, 030204 cardiovascular system & hematology, Diabete, Kidney, Aparato circulatorio, Azúcar, chemistry.chemical_compound, Mineralocorticoid Receptor Antagonists/therapeutic use, 0302 clinical medicine, Medicine and Health Sciences, Diabetic Nephropathies, Myocardial infarction, Renal Insufficiency, Chronic, Aldosterone, Outcome, Mineralocorticoid Receptor Antagonists, RISK, COMPLICATIONS, Diabetes, Middle Aged, SPIRONOLACTONE, CHRONIC HEART-FAILURE, Treatment Outcome, Mineralocorticoid, Nephrology, Cardiovascular Diseases, Research Design, Disease Progression, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, Type 2, Glomerular Filtration Rate, medicine.medical_specialty, Finerenone, Naphthyridines/therapeutic use, Renal function, Outcomes, 03 medical and health sciences, Clinical, Double-Blind Method, Diabetes mellitus, Internal medicine, medicine, Diabetes Mellitus, Humans, Naphthyridines, Renal Insufficiency, Chronic, ANTAGONIST, Sistema cardiovascular, Aged, Patient-Oriented, Translational Research: Research Article, Diabetic Nephropathies/complications, Renal Insufficiency, Chronic/drug therapy, RECEPTOR, Aldosterone, Clinical, Diabetes, Kidney, Mineralocorticoid, Outcomes, business.industry, Cardiovascular Diseases/epidemiology, Diabetes Mellitus, Type 2/complications, MILD, WORSENING RENAL-FUNCTION, EFFICACY, medicine.disease, chemistry, Diabetes Mellitus, Type 2, Spironolactone, Albuminuria, business, Kidney disease, Follow-Up Studies
Abstract

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate ≥25 mL/min/1.73 m2 and albuminuria (urinary albumin-to-creatinine ratio ≥30 to ≤5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level α = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.

Published
2019
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45. Empyema associated with a cough-induced rib fracture

Author

Masayuki Kashima and Satoshi Hayano

Subjects
Adult, Male, medicine.medical_specialty, Rib Fractures, Pleural effusion, Diaphragmatic breathing, Case Report, 03 medical and health sciences, 0302 clinical medicine, medicine, Persistent cough, Humans, 030212 general & internal medicine, Lung, business.industry, 030208 emergency & critical care medicine, General Medicine, Emergency department, medicine.disease, Right seventh rib, pneumonia (infectious disease), Empyema, respiratory tract diseases, Surgery, Pleural Effusion, medicine.anatomical_structure, Cough, empyema, Tube placement, business
Abstract

A 44-year-old man presented to the emergency department with fever and right anterior chest pain. He reported a persistent cough and the development of sudden-onset right anterior chest pain after coughing. The inspiratory pain in the right lung was severe, and therefore deep breathing was impossible. Chest CT revealed a fracture in the right seventh rib with consolidation and pleural effusion. A pleural fluid culture test result was positive for methicillin-susceptible Staphylococcus aureus. He was diagnosed with empyema associated with a cough-induced rib fracture. Thoracic drainage tube placement and intravenous antibiotic therapy successfully ameliorated his condition. He was discharged on day 13 and switched to an 8-week course of oral antibiotic therapy. There was no clinical relapse at the 6-month follow-up.

Published
2021
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47. HbA1c and Aortic Calcification Index as Noninvasive Predictors of Pre-Existing Histopathological Damages in Living Donor Kidney Transplantation

Author

Shigeyoshi Yamanaga, Hiroshi Yokomizo, Satoshi Hamanoue, Kohei Kinoshita, Yuji Hidaka, Mariko Toyoda, Kosuke Tanaka, Akari Kaba, Toshinori Ishizuka, Sho Nishida, Asami Takeda, Masayuki Kashima, Chiaki Kawabata, Akira Miyata, and Kenji Okumura

Subjects
medicine.medical_specialty, HbA1c, 030232 urology & nephrology, Urology, lcsh:Medicine, Renal function, Aortic calcification, 030230 surgery, Living donor, Article, 03 medical and health sciences, 0302 clinical medicine, medicine, Kidney transplantation, Kidney, business.industry, lcsh:R, Significant difference, aortic calcification index, General Medicine, medicine.disease, medicine.anatomical_structure, Blood pressure, renal function recovery, Hemoglobin, business, renal aging
Abstract

We previously reported that allografts from living donors may have pre-existing histopathological damages, defined as the combination of interstitial fibrosis (ci), tubular atrophy (ct), and arteriolar hyalinosis (ah) scores of ≧1, according to the Banff classification. We examined preoperative characteristics to identify whether the degree of these damages was related to metabolic syndrome-related factors of donors. We conducted a single-center cross-sectional analysis including 183 living kidney donors. Donors were divided into two groups: chronic change (ci + ct ≧ 1 &cap, ah ≧ 1, n = 27) and control (n = 156). Preoperative characteristics, including age, sex, blood pressure, hemoglobin A1c (HbA1c), aortic calcification index (ACI), and psoas muscle index (PMI), were analyzed. Comparing the groups, the baseline estimated glomerular filtration rate was not significantly different, however, we observed a significant difference for ACI (p = 0.009). HbA1c (p = 0.016) and ACI (p = 0.006) were independent risk factors to predict pre-existing histopathological damages, whereas PMI was not. HbA1c correlated with ct scores (p = 0.035), and ACI correlated with ci (p = 0.005), ct (p = 0.021), and ah (p = 0.017). HbA1c and ACI may serve as preoperative markers for identifying pre-existing damages on the kidneys of living donors.

Published
2020
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48. Study on Flexible Aerial Signature Individual Authentication System using the Finger Discrimination Information

Author

Masayuki Kashima, Kiminori Sato, Mutsumi Watanabe, and Hatanaka Issei

Subjects
Computer science, 0202 electrical engineering, electronic engineering, information engineering, Media Technology, 020206 networking & telecommunications, 020201 artificial intelligence & image processing, 02 engineering and technology, Authentication system, Electrical and Electronic Engineering, Computer security, computer.software_genre, computer, Signature (logic), Computer Science Applications
Published
2016
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49. Field Trial of Long-Reach and High-Splitting λ-Tunable TWDM-PON

Author

Hideaki Tamai, Yoshikazu Fujita, Akihiro Otaka, Masayuki Kashima, Akiya Suzuki, Shunji Kimura, Masamichi Fujiwara, Toshiaki Mukojima, Ken-Ichi Suzuki, Kota Asaka, Masahiro Sarashina, Katsuhisa Taguchi, Hideyuki Iwamura, Satoshi Furusawa, Shin Kaneko, and Tomoaki Yoshida

Subjects
Engineering, business.industry, Optical cross-connect, 02 engineering and technology, Optical performance monitoring, Passive optical network, Atomic and Molecular Physics, and Optics, 020210 optoelectronics & photonics, Optical Transport Network, Wavelength-division multiplexing, 0202 electrical engineering, electronic engineering, information engineering, Electronic engineering, Fiber optic splitter, business, Optical add-drop multiplexer, Optical communications repeater
Abstract

This paper presents the world's first field trial of a 40-km reach and over 512-split symmetric-rate 40-Gbit/s λ-tunable time and wavelength division multiplexing passive optical network (TWDM-PON) that utilizes our newly developed high-speed λ-tunable optical network unit transceivers and automatic gain controlled semiconductor optical amplifier-based PON extender for repeater and central office use. The upstream signals for C-band and downstream signals for L+-band in our developed λ-tunable TWDM-PON comply with the wavelength plan of ITU-T G.989 series. In a field trial, we successfully demonstrate error free λ-tunable transmission for the 40-km reach and 1024-split (maximum number) symmetric-rate 40-Gbit/s λ-tunable TWDM-PON over installed standard single-mode fiber links, and advanced network functions such as dynamic load balancing, incremental system upgrade, optical subscriber unit protection, and OLT equipment power saving are also confirmed.

Published
2016
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50. Mental Stress Recognition based on Non-invasive and Non-contact Measurement from Stereo Thermal and Visible Sensors

Author

Mutsumi Watanabe, Masayuki Kashima, Kiminori Sato, and Mohd Norzali Haji Mohd

Subjects
Non contact measurement, Computer science, Image quality, business.industry, Mental stress, Non invasive, Thermal, Scale-invariant feature transform, Computer vision, Artificial intelligence, business, Extractor, Camera resectioning
Abstract

This paper aims to present a novel methodology for real time monitoring of Internal Emotion State (Mental Stress). The method does not require any contact as contact measurement tend to effect emotions and burden physiologically. We have found out that user stress is correlated with the increased blood flow in three facial areas of sympathetic importance which is periorbital, supraorbital and maxillary. This increased blood flow dissipates convective heat which can be monitored through thermal imaging. In the stress experiment conducted, blood vessel is also detected via thermal imaging for several subjects in real time. Thermal infrared and visible cameras are being used in the stimulus experiment. Sample of several faces are also taken in real time in our experimental setup to measure the effectiveness of our method. Almost 98% of correct measurement of ROI and temperature was detected. The results of temperature before and after stress stimulus experiment are also compared and show promising results. In this paper also, a new method for detecting facial feature in both thermal and visual is presented by applying Nostril Mask, which allows one to find facial feature namely nose area in thermal and visual. Graph Cut algorithm is applied to remove unwanted ROI and correctly detect precise temperature values. Extraction of thermal-visual facial feature images is done by using Scale Invariant Feature Transform (SIFT) Feature detector and extractor to verify the method of using nostril mask. Based on the experiment conducted, it shows 88.6% of correct matching. An Accurate and efficient thermal-infrared camera calibration is also important for advancing computer vision research approach for geometrically calibrating individual and multiple cameras in both thermal and visible modalities. We also propose new printed Fever Cold Plaster (FCP) chessboard using a popular existing approach which is comparatively accurate and simple to execute. Based on the experiment conducted by comparing the degradation of image quality with the current approach, our proposed chessboard can be more clearly located than those on the applied standard chessboard by 39%.

Published
2015
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