Search

Your search keyword '"Mascolo, D"' showing total 102 results
Start Over Author "Mascolo, D"
102 results on '"Mascolo, D"'

7. A model for oxidation kinetics in air at room temperature of hydrogen-terminated (1 0 0) Si

Author

Cerofolini, G.F., Mascolo, D., and Vlad, M.O.

Subjects
Oxidation-reduction reaction -- Analysis, Hydrogen -- Chemical properties, Stoichiometry -- Research, Silicon -- Chemical properties, Physics
Abstract

A quantitative model is proposed for the description for the oxidation kinetics in air at room temperature of single crystalline, hydrogen-terminated, (1 0 0) silicon. The theory separates the growth kinetics of the interfacial suboxide from those of the outer stoichiometric oxide.

Published
2006

10. Integrated Thermoelectric Generator and related Method of Fabrication

Author

Iulianella, E, NARDUCCI, DARIO, Spaziani, F, Mascolo, D, Buosciolo, A, Latessa, G, Gison, I., Iulianella, E, Narducci, D, Spaziani, F, Mascolo, D, Buosciolo, A, Latessa, G, and Gison, I

Subjects
CHIM/02 - CHIMICA FISICA, FIS/01 - FISICA SPERIMENTALE, Thermoelectricity
Published
2016

11. Emergenza Ictus: costituzione di una rete di stroke unit adeguate alle esigenze assistenziali e conforme agli aspetti giuridico normativi nella Regione Campania

Author

TRIASSI, MARIA, MARASCO G, GIORDANO V, BERNARDO A, BUONOMO M, SPIRITO G, NOCERINO A, QUARTUCCI F, ARTUSO F, GRIMALDI MC, FABBROCINI M, MORETTO S, GRANATA A, DIANA MV, FORMICOLA M, DE LUCA L, DE LIGUORI P, DE MARCO G, MASCOLO D, PASSARO M, SAVOIA F, PELUSO C, PIZZA A, BOTTA E, CACACE G, MAUTONE P, AMBROSIO F, MANNA A, ACAMPORA E, BUSIELLO, Triassi, Maria, Marasco, G, Giordano, V, Bernardo, A, Buonomo, M, Spirito, G, Nocerino, A, Quartucci, F, Artuso, F, Grimaldi, Mc, Fabbrocini, M, Moretto, S, Granata, A, Diana, Mv, Formicola, M, DE LUCA, L, DE LIGUORI, P, DE MARCO, G, Mascolo, D, Passaro, M, Savoia, F, Peluso, C, Pizza, A, Botta, E, Cacace, G, Mautone, P, Ambrosio, F, Manna, A, Acampora, E, and Busiello

Published
2010

12. La direzione infermieristica e tecnica nelle aziende sanitarie: fondamenti organizzativi e giuridici

Author

TRIASSI, MARIA, DE LEO G, GIORDANO V, BERNARDO A, SPIRITO G, BUONOMO M, QUARTUCCI F, NOCERINO A, IANNUZZO MT, ARTUSO F, MORETTO S, GRANATA A, DIANA MV, FORMICOLA M, DE MARCO G, DE LUCA L, DE LIGUORI P, MASCOLO D, PASSARO M, SAVOIA F, GRIMALDI MC, PELUSO C, PIZZA A, BOTTA E, CACACE G, MAUTONE P, AMBROSIO F, FABBROCINI M, BUSIELLO F., Triassi, Maria, DE LEO, G, Giordano, V, Bernardo, A, Spirito, G, Buonomo, M, Quartucci, F, Nocerino, A, Iannuzzo, Mt, Artuso, F, Moretto, S, Granata, A, Diana, Mv, Formicola, M, DE MARCO, G, DE LUCA, L, DE LIGUORI, P, Mascolo, D, Passaro, M, Savoia, F, Grimaldi, Mc, Peluso, C, Pizza, A, Botta, E, Cacace, G, Mautone, P, Ambrosio, F, Fabbrocini, M, and Busiello, F.

Published
2010

13. La gestione del rischio clinico nell’unità di gastroenterologia ed endoscopia digestiva

Author

TRIASSI, MARIA, DE LUCA L, GIORDANO V, BERNARDO A, BUONOMO M, SPIRITO G, QUARTUCCI F, ARTUSO F, MORETTO S, GRANATA A, DIANA MV, FORMICOLA M, MASCOLO D, TORRE G, DE MARCO G, NOCERINO A, DE LIGUORI P, PASSARO M, PIZZA A, SAVOIA F, PELUSO C, BOTTA E, CACACE G, MAUTONE P, FABBROCINI M, AMBROSIO F, GIORDANO G., Triassi, Maria, DE LUCA, L, Giordano, V, Bernardo, A, Buonomo, M, Spirito, G, Quartucci, F, Artuso, F, Moretto, S, Granata, A, Diana, Mv, Formicola, M, Mascolo, D, Torre, G, DE MARCO, G, Nocerino, A, DE LIGUORI, P, Passaro, M, Pizza, A, Savoia, F, Peluso, C, Botta, E, Cacace, G, Mautone, P, Fabbrocini, M, Ambrosio, F, and Giordano, G.

Published
2010

14. La Neurochirurgia dei tumori cerebrali in Campania: analisi di attività e progetto di management sanitario

Author

TRIASSI, MARIA, SCHONAUER E, ARTUSO F, BUONOMO M, GIORDANO V, BERNARDO A, QUARTUCCI F, SPIRITO G, IANNUZZO MT, MORETTO S, GRANATA A, DIANA MV, FORMICOLA M, DE LUCA L, AVITABILE F, MASCOLO D, NOCERINO A, DE LIGUORI P, PASSARO M, DE MARCO G, SAVOIA F, PELUSO C, BOTTA E, CACACE G, DE LUCA, PIZZA A, FABBROCINI M, MAUTONE P, AMBROSIO F, BUSIELLO F., Triassi, Maria, Schonauer, E, Artuso, F, Buonomo, M, Giordano, V, Bernardo, A, Quartucci, F, Spirito, G, Iannuzzo, Mt, Moretto, S, Granata, A, Diana, Mv, Formicola, M, DE LUCA, L, Avitabile, F, Mascolo, D, Nocerino, A, DE LIGUORI, P, Passaro, M, DE MARCO, G, Savoia, F, Peluso, C, Botta, E, Cacace, G, De, Luca, Pizza, A, Fabbrocini, M, Mautone, P, Ambrosio, F, and Busiello, F.

Published
2010

15. Percorso assistenziale per gli utenti geriatrici con frattura di femore ed organizzazione delle attività ospedaliere. L’integrazione dei profili assistenziali della presa in carico alla domiciliazione dell’utente secondo il dettato organizzativo e legislativo

Author

TRIASSI, MARIA, DI MARO G, GIORDANO V, BERNARDO A, SPIRITO G, QUARTUCCI F, IANNUZZO MT, BUONOMO M, ARTUSO F, GRIMALDI MC, MORETTO S, GRANATA A, DIANA MV, DE MARCO G, FORMICOLA M, DE LUCA L, NOCERINO A, DE LIGUORI P, MASCOLO D, PASSARO M, SAVOIA F, PELUSO C, PIZZA A, BOTTA E, CACACE G, MAUTONE P, AMBROSIO F, MANNA A, ACAMPORA E, GIORDANO G., Triassi, Maria, DI MARO, G, Giordano, V, Bernardo, A, Spirito, G, Quartucci, F, Iannuzzo, Mt, Buonomo, M, Artuso, F, Grimaldi, Mc, Moretto, S, Granata, A, Diana, Mv, DE MARCO, G, Formicola, M, DE LUCA, L, Nocerino, A, DE LIGUORI, P, Mascolo, D, Passaro, M, Savoia, F, Peluso, C, Pizza, A, Botta, E, Cacace, G, Mautone, P, Ambrosio, F, Manna, A, Acampora, E, and Giordano, G.

Published
2010

16. La rimodulazione delle attività sanitarie in un distretto sanitario di base. Finalizzare l’organizzazione delle attività per una reale integrazione ospedale territorio. Il valore degli indicatori di attività e i determinanti epidemiologici per intercettare i bisogni di salute

Author

TRIASSI, MARIA, QUARTUCCI F, GIORDANO V, BERNARDO A, BUONOMO M, SPIRITO G, NOCERINO A, ARTUSO F, DE LIGUORI P, MORETTO S, GRANATA A, DIANA MV, FORMICOLA M, MASCOLO D, PASSARO M, SAVOIA F, DE MARCO G, PELUSO C, BOTTA E, CACACE G, FABBROCINI M, PIZZA A, DE LUCA L, MAUTONE P, AMBROSIO F, MANNA A, ACAMPORA E, BUSIELLO F., Triassi, Maria, Quartucci, F, Giordano, V, Bernardo, A, Buonomo, M, Spirito, G, Nocerino, A, Artuso, F, DE LIGUORI, P, Moretto, S, Granata, A, Diana, Mv, Formicola, M, Mascolo, D, Passaro, M, Savoia, F, DE MARCO, G, Peluso, C, Botta, E, Cacace, G, Fabbrocini, M, Pizza, A, DE LUCA, L, Mautone, P, Ambrosio, F, Manna, A, Acampora, E, and Busiello, F.

Published
2010

17. L’assistenza nelle cure domiciliari: dalla comunicazione all’educazione dei caregiver, nel rispetto della normativa e dei livelli professionali specifici

Author

TRIASSI, MARIA, PELUSO C, GIORDANO V, BERNARDO A, BUONOMO M, SPIRITO G, NOCERINO A, ARTUSO F, QUARTUCCI F, MORETTO S, GRANATA A, DIANA MV, FORMICOLA M, MASCOLO D, PASSARO M, AVITABILE F, SAVOIA F, DE MARCO G, DE LUCA L, DE LIGUORI P, PIZZA A, BOTTA E, CACACE G, FABBROCINI M, MAUTONE P, AMBROSIO F, MANNA A, ACAMPORA E, BUSIELLO F., Triassi, Maria, Peluso, C, Giordano, V, Bernardo, A, Buonomo, M, Spirito, G, Nocerino, A, Artuso, F, Quartucci, F, Moretto, S, Granata, A, Diana, Mv, Formicola, M, Mascolo, D, Passaro, M, Avitabile, F, Savoia, F, DE MARCO, G, DE LUCA, L, DE LIGUORI, P, Pizza, A, Botta, E, Cacace, G, Fabbrocini, M, Mautone, P, Ambrosio, F, Manna, A, Acampora, E, and Busiello, F.

Published
2010

18. Il 'governo' del blocco operatorio in ospedale: dalla valutazione della performance alla gestione del rischio

Author

TRIASSI, MARIA, IANNUZZO MT, GIORDANO V, BERNARDO A, BUONOMO M, SPIRITO G, QUARTUCCI F, NOCERINO A, PIZZA A, ARTUSO F, MORETTO S, GRANATA A, DIANA MV, AVITABILE F, FORMICOLA M, MASCOLO D, PASSARO M, SAVOIA F, DE LIGUORI P, PELUSO C, BOTTA E, CACACE G, MAUTONE P, AMBROSIO F, MANNA A, ACAMPORA E, DE LUCA L, GIORDANO G., Triassi, Maria, Iannuzzo, Mt, Giordano, V, Bernardo, A, Buonomo, M, Spirito, G, Quartucci, F, Nocerino, A, Pizza, A, Artuso, F, Moretto, S, Granata, A, Diana, Mv, Avitabile, F, Formicola, M, Mascolo, D, Passaro, M, Savoia, F, DE LIGUORI, P, Peluso, C, Botta, E, Cacace, G, Mautone, P, Ambrosio, F, Manna, A, Acampora, E, DE LUCA, L, and Giordano, G.

Published
2010

19. Organizzazione percorsi assistenziali multilivello in cardiologia. La gestione dell’IMA con st sopra o sottoslivellato, con percorsoi definiti pre ricovero, intraospedalieri e post dimissione: impatto nell’organizzazione e nei fondamenti giuridici del rischio clinico

Author

TRIASSI, MARIA, DEDIVITIIS M, GIORDANO V, BERNARDO A, SPIRITO G, QUARTUCCI F, BUONOMO M, IANNUZZO MT, ARTUSO F, MORETTO S, GRANATA A, DIANA MV, FORMICOLA M, AVITABILE F, DE MARCO G, MASCOLO D, PASSARO M, SAVOIA F, DE LIGUORI P, NOCERINO A, PELUSO C, PIZZA A, BOTTA E, CACACE G, MAUTONE P, AMBROSIO F, BUSIELLO F, DE LUCA L., Triassi, Maria, Dedivitiis, M, Giordano, V, Bernardo, A, Spirito, G, Quartucci, F, Buonomo, M, Iannuzzo, Mt, Artuso, F, Moretto, S, Granata, A, Diana, Mv, Formicola, M, Avitabile, F, DE MARCO, G, Mascolo, D, Passaro, M, Savoia, F, DE LIGUORI, P, Nocerino, A, Peluso, C, Pizza, A, Botta, E, Cacace, G, Mautone, P, Ambrosio, F, Busiello, F, and DE LUCA, L.

Published
2010

20. Modelli organizzativo gestionali del blocco operatorio, definizione di specifici setting assistenziali integrati nell’ottica della teoria prestazionale applicata in sanità

Author

TRIASSI, MARIA, BUONOMO M, GIORDANO V, BERNARDO A, QUARTUCCI F, SPIRITO G, IANNUZZO MT, NOCERINO A, ARTUSO F, MORETTO S, GRANATA A, DIANA MV, FORMICOLA M, MASCOLO D, PASSARO M, SAVOIA F, PELUSO C, PIZZA A, BOTTA E, CACACE G, FABBROCINI M, MAUTONE P, AMBROSIO F, DE MARCO G, MANNA A, ACAMPORA E, GIORDANO G, DE LUCA L., Triassi, Maria, Buonomo, M, Giordano, V, Bernardo, A, Quartucci, F, Spirito, G, Iannuzzo, Mt, Nocerino, A, Artuso, F, Moretto, S, Granata, A, Diana, Mv, Formicola, M, Mascolo, D, Passaro, M, Savoia, F, Peluso, C, Pizza, A, Botta, E, Cacace, G, Fabbrocini, M, Mautone, P, Ambrosio, F, DE MARCO, G, Manna, A, Acampora, E, Giordano, G, and DE LUCA, L.

Published
2010

21. L’osservazione breve pediatrica: modalità organizzative, caratteristiche gestionali, finalità tendenti all’appropriatezza clinica nell’ottica della razionalizzazione delle attività aziendali e della corretta allocazione di utente e risorse

Author

D’AVINO P, GIORDANO V, BERNARDO A, NOCERINO A, SPIRITO G, DELLA VECCHIA A, MANNA A, CUCCARO P, DI RESTA M, MASCOLO D, AVITABILE F, MATARANTE E, BOTTA E, CACACE G, CAPPUCCIO A, DE MARCO G, TRIASSI, MARIA, D’Avino, P, Giordano, V, Bernardo, A, Nocerino, A, Spirito, G, DELLA VECCHIA, A, Manna, A, Cuccaro, P, DI RESTA, M, Mascolo, D, Avitabile, F, Matarante, E, Botta, E, Cacace, G, Cappuccio, A, DE MARCO, G, and Triassi, Maria

Published
2009

22. L’accreditamento istituzionale in nefrologia: leva organizzativa per definire modelli applicativi sperimentali in un UOC di Nefrologia di P.O. di ASL territoriale

Author

NAPPI F, GIORDANO V, BERNARDO A, NOCERINO A, SPIRITO G, FABBROCINI M, DELLA VECCHIA A, CUCCARO P, MOLESE A, DI RESTA M, REA T, MASCOLO D, AVITABILE F, MATARANTE E, BOTTA E, CACACE G, CAPPUCCIO A, DE MARCO G, TRIASSI, MARIA, Nappi, F, Giordano, V, Bernardo, A, Nocerino, A, Spirito, G, Fabbrocini, M, DELLA VECCHIA, A, Cuccaro, P, Molese, A, DI RESTA, M, Rea, T, Mascolo, D, Avitabile, F, Matarante, E, Botta, E, Cacace, G, Cappuccio, A, DE MARCO, G, and Triassi, Maria

Published
2009

23. 'Progetto Pharma - Uni - Hospital'. Integrare le funzioni di una U.O.C. Farmacia ospedaliera secondo logiche di pharmaceutical governance mediante una piattaforma unica di servizi per una tracciabilità del farmaco in un’ottica di rete integrata

Author

FUCILE AM, GIORDANO V, BERNARDO A, NOCERINO A, SPIRITO G, DELLA VECCHIA A, MOLESE A, CUCCARO P, DI RESTA M, MASCOLO D, AVITABILE F, MATARANTE E, BOTTA E, CACACE G, CAPPUCCIO A, DE MARCO G, TRIASSI, MARIA, Fucile, Am, Giordano, V, Bernardo, A, Nocerino, A, Spirito, G, DELLA VECCHIA, A, Molese, A, Cuccaro, P, DI RESTA, M, Mascolo, D, Avitabile, F, Matarante, E, Botta, E, Cacace, G, Cappuccio, A, DE MARCO, G, and Triassi, Maria

Subjects
Progetto Pharma
Published
2009

24. Ipotesi organizzativa di un day service per il trattamento delle varici degli arti inferiori

Author

ABATE LV, GIORDANO V, FABBROCINI M, BERNARDO A, NOCERINO A, SPIRITO G, MOLESE A, DELLA VECCHIA A, REA T, CUCCARO P, BOTTA E, CACACE G, CAPPUCCIO A, DE MARCO G, DI RESTA M, MASCOLO D, AVITABILE F, MATARANTE E, TRIASSI, MARIA, Abate, Lv, Giordano, V, Fabbrocini, M, Bernardo, A, Nocerino, A, Spirito, G, Molese, A, DELLA VECCHIA, A, Rea, T, Cuccaro, P, Botta, E, Cacace, G, Cappuccio, A, DE MARCO, G, DI RESTA, M, Mascolo, D, Avitabile, F, Matarante, E, and Triassi, Maria

Published
2009

25. Dall’appropriatezza organizzativa al recupero dei livelli di efficienza nelle attività integrate di Day Surgery in un IRCCS

Author

DEL GIUDICE M, GIORDANO V, FABBROCINI M, BERNARDO A, NOCERINO A, DELLA VECCHIA A, SPIRITO G, GIORDANO G, MANNA A, CUCCARO P, DI RESTA M, MASCOLO D, AVITABILE F, MATARANTE E, BOTTA E, CACACE G, CAPPUCCIO A, DE MARCO G, TRIASSI, MARIA, DEL GIUDICE, M, Giordano, V, Fabbrocini, M, Bernardo, A, Nocerino, A, DELLA VECCHIA, A, Spirito, G, Giordano, G, Manna, A, Cuccaro, P, DI RESTA, M, Mascolo, D, Avitabile, F, Matarante, E, Botta, E, Cacace, G, Cappuccio, A, DE MARCO, G, and Triassi, Maria

Published
2009

26. La filiera assistenziale in U.O.M.I: il 'consultorio' fra strutture aziendali e integrazione assistenziale. Impatto sull’organizzazione aziendale e sul tessuto socio sanitario di riferimento

Author

AMBROSIO F, GIORDANO V, SPIRITO G, DELLA VECCHIA A, FABBROCINI M, MANNA A, RICCO CS, BERNARDO A, NOCERINO A, CUCCARO P, GIORDANO G, REA T, DI RESTA M, MASCOLO D, AVITABILE F, MATARANTE E, BOTTA E, CACACE G, CAPPUCCIO A, DE MARCO G, TRIASSI, MARIA, Ambrosio, F, Giordano, V, Spirito, G, DELLA VECCHIA, A, Fabbrocini, M, Manna, A, Ricco, C, Bernardo, A, Nocerino, A, Cuccaro, P, Giordano, G, Rea, T, DI RESTA, M, Mascolo, D, Avitabile, F, Matarante, E, Botta, E, Cacace, G, Cappuccio, A, DE MARCO, G, and Triassi, Maria

Published
2009

27. Modello di gestione di un poliambulatorio specialistico territoriale e progetto di day service per patologie ad alta prevalenza e/o complessità nell’ambito di un poliambulatorio distrettuale

Author

BARLETTA M, GIORDANO V, BERNARDO A, DELLA VECCHIA A, MATARANTE E, AVITABILE F, DE MARCO G, MASCOLO D, NOCERINO A, CUCCARO, PATRIZIA, PAUDICE, ALESSANDRO, TRIASSI, MARIA, Barletta, M, Giordano, V, Bernardo, A, Cuccaro, Patrizia, DELLA VECCHIA, A, Paudice, Alessandro, Matarante, E, Avitabile, F, DE MARCO, G, Mascolo, D, Nocerino, A, and Triassi, Maria

Published
2008

29. Combined IR and XPS analysis of the native (100) surface of single crystalline silicon after HFaq etching

Author

Cerofolini, GF, Giussani, A, Carone Fabiani, F, Modelli, A, Mascolo, D, Ruggiero, D, NARDUCCI, DARIO, Romano, E., Cerofolini, G, Giussani, A, Carone Fabiani, F, Modelli, A, Mascolo, D, Ruggiero, D, Narducci, D, and Romano, E

Subjects
Angle-resolved XPS, MIR IR, Silicon surface
Abstract

A combined analysis, based on angle-resolved X-ray photoelectron spectroscopy and multiple-internalreflection infrared spectroscopy, of the (100) silicon surface after etching in dilute aqueous solution of HF is presented. The analysis shows that the surface is mainly formed by a heterogeneous distribution of SiH, SiH2 and SiH3 terminations, but contains (in addition to sub-stoichiometric oxidized silicon) a form of reduced silicon, not consistent with the currently accepted picture of the native HFaq-etched surface. Copyright © 2007 John Wiley & Sons, Ltd.

Published
2007

36. Chemical, energetic, and geometric heterogeneity of device-quality (1 0 0) surfaces of single crystalline silicon after HFaq etching’

Author

Cerofolini, G, Giussani, A, Modelli, A, Mascolo, D, Ruggiero, D, Narducci, D, Romano, E, Cerofolini, GF, Romano, E., NARDUCCI, DARIO, Cerofolini, G, Giussani, A, Modelli, A, Mascolo, D, Ruggiero, D, Narducci, D, Romano, E, Cerofolini, GF, Romano, E., and NARDUCCI, DARIO

Abstract

An analysis, based on angle-resolved X-ray photoelectron spectroscopy, multiple-internal-reflection infrared spectroscopy, and atomic force microscopy, of device-quality (1 0 0)silicon surfaces after etching in dilute aqueous solution of HF is presented. The analysis shows that the surface is mainly formed by a heterogeneous distribution of SiH, SiH2and SiH3 terminations, but contains sub-stoichiometric oxidized silicon. The analysis shows moreover the existence of a form of reduced silicon, not consistent with the currently accepted picture of the native HFaq-etched surface. © 2008 Elsevier B.V. All rights reserved.

Published
2008

37. Combined IR and XPS analysis of the native (100) surface of single crystalline silicon after HFaq etching

Author

Cerofolini, G, Giussani, A, Carone Fabiani, F, Modelli, A, Mascolo, D, Ruggiero, D, Narducci, D, Romano, E, Cerofolini, GF, NARDUCCI, DARIO, Romano, E., Cerofolini, G, Giussani, A, Carone Fabiani, F, Modelli, A, Mascolo, D, Ruggiero, D, Narducci, D, Romano, E, Cerofolini, GF, NARDUCCI, DARIO, and Romano, E.

Abstract

A combined analysis, based on angle-resolved X-ray photoelectron spectroscopy and multiple-internalreflection infrared spectroscopy, of the (100) silicon surface after etching in dilute aqueous solution of HF is presented. The analysis shows that the surface is mainly formed by a heterogeneous distribution of SiH, SiH2 and SiH3 terminations, but contains (in addition to sub-stoichiometric oxidized silicon) a form of reduced silicon, not consistent with the currently accepted picture of the native HFaq-etched surface. Copyright © 2007 John Wiley & Sons, Ltd.

Published
2007

38. Printed Functionalized Capacitors for Water-Induced Label-Free Detection of DNA Hybridization

Author

Mascolo, D., primary, Pascale, E., additional, Petrone, I., additional, Vecchione, R., additional, Volpe, M.V., additional, Malagnino, N., additional, Ruggiero, D., additional, Foncellino, F., additional, Bevilacqua, M.F., additional, Di Palma, V., additional, Cimmino, A., additional, Casuscelli, V., additional, Scaldaferri, R., additional, Pedaci, I., additional, Di Matteo, A., additional, Napolitano, T., additional, Salzillo, G., additional, Porro, F., additional, Maglione, M.G., additional, and Occhipinti, L., additional

Published
2011
Full Text
View/download PDF

47. Modulating the vascular behavior of metastatic breast cancer cells by curcumin treatment.

Author

Palange, A. L., Di Mascolo, D., Singh, J., De Franceschi, M. S., Carallo, C., Gnasso, A., and Decuzzi, P.

Subjects
BREAST cancer treatment, METASTASIS, CANCER cells, BLOOD vessels, CURCUMIN
Abstract

The spreading of tumor cells to secondary sites (tumor metastasis) is a complex process that involves multiple, sequential steps. Vascular adhesion and extravasation of circulating tumor cells (CTCs) is one, critical step. Curcumin, a natural compound extracted from Curcuma longa, is known to have anti-tumoral, anti-proliferative, anti-inflammatory properties and affect the expression of cell adhesion molecules, mostly by targeting the NF-κB transcription factor. Here, upon treatment with Curcumin, the vascular behavior of three different estrogen receptor negative (ER-) breast adenocarcinoma cell lines (SK-BR-3, MDA-MB-231, MDA-MB-468) is analyzed using a microfluidic system. First, the dose response to curcumin is characterized at 24, 48 and 72h using a XTT assay. For all three cell lines, an IC50 larger than 20 μM is observed at 72 h; whereas no significant reduction in cell viability is detected for curcumin concentrations up to 10 μM. Upon 24 h treatment at 10 μM of curcumin, SK-BR3 and MDA-MB-231 cells show a decrease in adhesion propensity of 40% (p = 0.02) and 47% (p = 0.001), respectively. No significant change is documented for the less metastatic MDA-MB-468 cells. All three treated cell lines show a 20% increase in rolling velocity from 48.3 to 58.7 μm/s in SK-BR-3, from 64.1 to 73.77 μm/s in MDAMB-231 and from 57.5 to 74.4 μm/s in MDA-MB-468. Collectively, these results suggest that mild curcumin treatments could limit the metastatic potential of these adenocarcinoma cell lines, possibly by altering the expression of adhesion molecules, and the organization and stiffness of the cell cytoskeleton. Future studies will elucidate the biophysical mechanisms regulating this curcumin-induced behavior and further explore the clinical relevance of these findings. [ABSTRACT FROM AUTHOR]

Published
2012
Full Text
View/download PDF

49. Ultrasound-induced deformation of PLGA-microPlates for on-command drug release

Author

M. De Vittorio, E. Sciurti, Francesco Rizzi, S.K. Padmanabhan, Antonio Balena, Rosita Primavera, Paolo Decuzzi, Aurora Rizzo, Daniele Di Mascolo, Sciurti, E., Primavera, R., Di Mascolo, D., Rizzo, A., Balena, A., Padmanabhan, S. K., Rizzi, F., Decuzzi, P., and De Vittorio, M.

Subjects
Materials science, Polymeric particles, 02 engineering and technology, 01 natural sciences, chemistry.chemical_compound, 0103 physical sciences, Ultrasound, Mechanical resonance, Electrical and Electronic Engineering, Transdermal, 010302 applied physics, business.industry, technology, industry, and agriculture, Triggered drug release, Drug delivery, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Piezoelectricity, Atomic and Molecular Physics, and Optics, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, PLGA, Transducer, chemistry, Polymeric particle, Ultrasonic sensor, 0210 nano-technology, business, Energy source, Biomedical engineering
Abstract

Transdermal drug delivery offers several advantages over other conventional modalities for drug administration, such as injections and oral administrations. It can be activated by exogenous energy sources, including electric and magnetic fields, or by light and ultrasound (US). Ultrasound can induce the degradation and deformation of a polymeric matrix, thus promoting the release of entrapped drugs and the topical administration through the skin. Our aim is to create a wearable patch composed of an ultrasound-responsive polymeric system encapsulating specific drugs, which are released on demand by the application of ultrasound. In this work, we investigate the effect of ultrasound on square poly(lactic-co-glycolic acid) (PLGA) microparticles loaded with curcumin (CURC), called curcumin-microplates (CURC-μPLs), realized using a top-down fabrication process. Using Finite Element Method (FEM) simulations, we identified the resonant frequencies and the mode shape of the μPLs. Guided by this simulation, we applied ultrasound stimulus at frequency of 1 MHz, close to the first mechanical resonance frequency of the microplates, leading to a 200% increase in CURC release rate after 30 min of ultrasonic treatment. This approach can be generalized to any ultrasound-sensitive matrix filled with specific drugs and with piezoelectric compliant transducers embedded in the smart patch for generating ultrasonic waves.

Published
2020

50. SERS analysis on exosomes using super-hydrophobic surfaces

Author

Maria Laura Coluccio, Angelo Accardo, Francesco Gentile, Salvatore A. Pullano, Daniele Di Mascolo, F. De Angelis, Gerardo Perozziello, Carlo Liberale, E. Di Fabrizio, Gobind Das, Marco Francardi, Patrizio Candeloro, Luca Tirinato, Tirinato, L., Gentile, Francesco, Di Mascolo, D., Coluccio, M. L., Das, G., Liberale, C., Pullano, S. A., Perozziello, G., Francardi, M., Accardo, A., De Angelis, F., Candeloro, P., and Di Fabrizio, E.

Subjects
Exosomes, Super-hydrophobic surface, SERS, Silver nano-grains, Atomic and Molecular Physics, and Optic, Surfaces, Coatings and Film, Nanotechnology, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Silver nano-grain, symbols.namesake, Biochemical composition, Electrical and Electronic Engineering, Friction coefficient, Chemistry, Electronic, Optical and Magnetic Material, Vesicle, Substrate (chemistry), Surface-enhanced Raman spectroscopy, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Atomic and Molecular Physics, and Optics, Microvesicles, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Exosome, Hydrophobic surfaces, symbols, 0210 nano-technology, Raman spectroscopy
Abstract

Exosomes are very small vesicles that are shed from a variety of cell types. They are present in body fluids comprising blood, urine and ascites, and they hold the potential to serve as indicators in the diagnosis, prognosis and surveillance of a variety of health conditions. In consideration of this, there is broad interest worldwide in deriving and understanding their biochemical composition. Here, small drops of solutions containing exosomes, isolated from either healthy (CCD841-CoN) or tumor (HCT116) colon cells, were manipulated using super-hydrophobic surfaces (SHSs) decorated with nano-geometry based photonics structures. SHSs are surfaces with superior properties, including a reduced friction coefficient, on account of which they can be used to control diluted solutions of biological or medical interest. The combination of this technology with optical resonance phenomena, open up terrific opportunities in the detection, analysis or characterization of biological compounds. Therefore, exosomes were conveniently concentrated and conveyed onto the Surface Enhanced Raman Spectroscopy (SERS) active areas of the substrate, whereby they were analyzed and characterized with extreme precision. Results indicate a difference in the concentration of some biological compounds, and namely: exosomes derived from healthy cells exhibit higher intensities of the peaks corresponding to lipids vibrations, while exosomes extracted from tumor cell lines exhibit a richer RNA content.

Published
2012

Catalog

Books, media, physical & digital resources
See catalog results