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304 results on '"Masignani, Vega"'

3. Genome Analysis of Multiple Pathogenic Isolates of Streptococcus agalactiae: Implications for the Microbial "Pan-Genome"

Author

Tettelin, Hervé, Masignani, Vega, Cieslewicz, Michael J., Donati, Claudio, Medini, Duccio, Ward, Naomi L., Angiuoli, Samuel V., Crabtree, Jonathan, Jones, Amanda L., Durkin, A. Scott, DeBoy, Robert T., Davidsen, Tanja M., Mora, Marirosa, Scarselli, Maria, Peterson, Jeremy D., Hauser, Christopher R., Sundaram, Jaideep P., Nelson, William C., Madupu, Ramana, Brinkac, Lauren M., Dodson, Robert J., Rosovitz, Mary J., Sullivan, Steven A., Daugherty, Sean C., Haft, Daniel H., Selengut, Jeremy, Gwinn, Michelle L., Zhou, Liwei, Zafar, Nikhat, Khouri, Hoda, Radune, Diana, Dimitrov, George, Watkins, Kisha, Smith, Shannon, Utterback, Teresa R., White, Owen, Rubens, Craig E., Grandi, Guido, Madoff, Lawrence C., Kasper, Dennis L., Telford, John L., Wessels, Michael R., Rappuoli, Rino, and Fraser, Claire M.

Published
2005

4. Complete Genome Sequence and Comparative Genomic Analysis of an Emerging Human Pathogen, Serotype V Streptococcus agalactiae

Author

Tettelin, Hervé, Masignani, Vega, Cieslewicz, Michael J., Eisen, Jonathan A., Peterson, Scott, Wessels, Michael R., Paulsen, Ian T., Nelson, Karen E., Margarit, Immaculada, Read, Timothy D., Madoff, Lawrence C., Wolf, Alex M., Beanan, Maureen J., Brinkac, Lauren M., Daugherty, Sean C., DeBoy, Robert T., Durkin, A. Scott, Kolonay, James F., Madupu, Ramana, Lewis, Matthew R., Radune, Diana, Fedorova, Nadezhda B., Scanlan, David, Khouri, Hoda, Mulligan, Stephanie, Carty, Heather A., Cline, Robin T., Van Aken, Susan E., Gill, John, Scarselli, Maria, Mora, Marirosa, Iacobini, Emilia T., Brettoni, Cecilia, Galli, Giuliano, Mariani, Massimo, Vegni, Filippo, Maione, Domenico, Rinaudo, Daniela, Rappuoli, Rino, Telford, John L., Kasper, Dennis L., Grandi, Guido, and Fraser, Claire M.

Published
2002

5. Complete Genome Sequence of Neisseria meningitidis Serogroup B Strain MC58

Author

Tettelin, Hervé, Saunders, Nigel J., Heidelberg, John, Jeffries, Alex C., Nelson, Karen E., Eisen, Jonathan A., Ketchum, Karen A., Hood, Derek W., Peden, John F., Dodson, Robert J., Nelson, William C., Gwinn, Michelle L., DeBoy, Robert, Peterson, Jeremy D., Hickey, Erin K., Haft, Daniel H., Salzberg, Steven L., White, Owen, Fleischmann, Robert D., Dougherty, Brian A., Mason, Tanya, Ciecko, Anne, Parksey, Debbie S., Blair, Eric, Cittone, Henry, Clark, Emily B., Cotton, Matthew D., Utterback, Terry R., Khouri, Hoda, Qin, Haiying, Vamathevan, Jessica, Gill, John, Scarlato, Vincenzo, Masignani, Vega, Pizza, Mariagrazia, Grandi, Guido, Sun, Li, Smith, Hamilton O., Fraser, Claire M., Moxon, E. Richard, Rappuoli, Rino, and Venter, J. Craig

Published
2000

6. Identification of Vaccine Candidates against Serogroup B Meningococcus by Whole-Genome Sequencing

Author

Pizza, Mariagrazia, Scarlato, Vincenzo, Masignani, Vega, Giuliani, Marzia Monica, Aricò, Beatrice, Comanducci, Maurizio, Jennings, Gary T., Baldi, Lucia, Bartolini, Erika, Capecchi, Barbara, Galeotti, Cesira L., Luzzi, Enrico, Manetti, Roberto, Marchetti, Elisa, Mora, Marirosa, Nuti, Sandra, Ratti, Giulio, Santini, Laura, Savino, Silvana, Scarselli, Maria, Storni, Elisa, Zuo, Peijun, Broeker, Michael, Hundt, Erika, Knapp, Bernard, Blair, Eric, Mason, Tanya, Tettelin, Hervé, Hood, Derek W., Jeffries, Alex C., Saunders, Nigel J., Granoff, Dan M., Venter, J. Craig, Moxon, E. Richard, Grandi, Guido, and Rappuoli, Rino

Published
2000

7. Expression of factor H binding protein in meningococcal strains can vary at least 15-fold and is genetically determined

Author

Biagini, Massimiliano, Spinsanti, Marco, De Angelis, Gabriella, Tomei, Sara, Ferlenghi, Ilaria, Scarselli, Maria, Rigat, Fabio, Messuti, Nicola, Biolchi, Alessia, Muzzi, Alessandro, Anderloni, Giulia, Brunelli, Brunella, Cartocci, Elena, Buricchi, Francesca, Tani, Chiara, Stella, Maria, Moschioni, Monica, Del Tordello, Elena, Colaprico, Annalisa, Savino, Silvana, Giuliani, Marzia M., Delany, Isabel, Pizza, Mariagrazia, Costantino, Paolo, Norais, Nathalie, Rappuoli, Rino, and Masignani, Vega

Published
2016

10. Bacterial Toxins

Author

Masignani, Vega, Pizza, Mariagrazia, Rappuoli, Rino, Rosenberg, Eugene, editor, DeLong, Edward F., editor, Lory, Stephen, editor, Stackebrandt, Erko, editor, and Thompson, Fabiano, editor

Published
2013
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11. Structure of the meningococcal vaccine antigen NadA and epitope mapping of a bactericidal antibody

Author

Malito, Enrico, Biancucci, Marco, Faleri, Agnese, Ferlenghi, Ilaria, Scarselli, Maria, Maruggi, Giulietta, Surdo, Paola Lo, Veggi, Daniele, Liguori, Alessia, Santini, Laura, Bertoldi, Isabella, Petracca, Roberto, Marchi, Sara, Romagnoli, Giacomo, Cartocci, Elena, Vercellino, Irene, Savino, Silvana, Spraggon, Glen, Norais, Nathalie, Pizza, Mariagrazia, Rappuoli, Rino, Masignani, Vega, and Bottomley, Matthew James

Published
2014

12. Identification of a Universal Group B Streptococcus Vaccine by Multiple Genome Screen

Author

Maione, Domenico, Margarit, Immaculada, Rinaudo, Cira D., Masignani, Vega, Mora, Marirosa, Scarselli, Maria, Tettelin, Hervé, Brettoni, Cecilia, Iacobini, Emilia T., Rosini, Roberto, D'Agostino, Nunzio, Miorin, Lisa, Buccato, Scilla, Mariani, Massimo, Galli, Giuliano, Nogarotto, Renzo, Dei, Vincenzo Nardi, Vegni, Filipo, Fraser, Claire, Mancuso, Giuseppe, Teti, Giuseppe, Madoff, Lawrence C., Paoletti, Lawrence C., Rappuoli, Rino, Kasper, Dennis L., Telford, John L., and Grandi, Guido

Published
2005

14. Genome-Based Vaccine Development: A Short Cut for the Future

Author

Moriel, Danilo Gomes, Scarselli, Maria, Serino, Laura, Mora, Marirosa, Rappuoli, Rino, Masignani, Vega, Back, Nathan, editor, Cohen, Irun R., editor, Lajtha, Abel, editor, Lambris, John D., editor, Paoletti, Rodolfo, editor, Guzmán, Carlos A., editor, and Feuerstein, Giora Z., editor

Published
2009
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15. Bacterial Toxins

Author

Masignani, Vega, Pizza, Mariagrazia, Rappuoli, Rino, Dworkin, Martin, editor, Falkow, Stanley, editor, Rosenberg, Eugene, editor, Schleifer, Karl-Heinz, editor, and Stackebrandt, Erko, editor

Published
2006
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16. Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen

Author

Malito, Enrico, Faleri, Agnese, Surdo, Paola Lo, Veggi, Daniele, Maruggi, Giulietta, Grassi, Eva, Cartocci, Elena, Bertoldi, Isabella, Genovese, Alessia, Santini, Laura, Romagnoli, Giacomo, Borgogni, Erica, Brier, Sébastien, Passo, Carla Lo, Domina, Maria, Castellino, Flora, Felici, Franco, van der Veen, Stijn, Johnson, Steven, Lea, Susan M., Tang, Christoph M., Pizza, Mariagrazia, Savino, Silvana, Norais, Nathalie, Rappuoli, Rino, Bottomley, Matthew J., and Masignani, Vega

Published
2013

18. A Universal Vaccine for Serogroup B Meningococcus

Author

Giuliani, Marzia M., Adu-Bobie, Jeannette, Comanducci, Maurizio, Aricò, Beatrice, Savino, Silvana, Santini, Laura, Brunelli, Brunella, Bambini, Stefania, Biolchi, Alessia, Capecchi, Barbara, Cartocci, Elena, Ciucchi, Laura, Di Marcello, Federica, Ferlicca, Francesca, Galli, Barbara, Luzzi, Enrico, Masignani, Vega, Serruto, Davide, Veggi, Daniele, Contorni, Mario, Morandi, Maurizio, Bartalesi, Alessandro, Cinotti, Vanda, Mannucci, Donatella, Titta, Francesca, Ovidi, Elisa, Welsch, Jo Anne, Granoff, Dan, Rappuoli, Rino, and Pizza, Mariagrazia

Published
2006
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21. Simple sequence repeats and genome plasticity in Streptococcus agalactiae

Author

Janulczyk, Robert, Masignani, Vega, Maione, Domenico, Tettelin, Herve, Grandi, Guido, and Telford, John L.

Subjects
Bacterial genetics -- Research, Streptococcus agalactiae -- Genetic aspects, Streptococcus agalactiae -- Physiological aspects, Adaptation (Physiology) -- Research, Biological sciences
Abstract

Simple sequence repeats (SSRs) and their role in phase variation have been extensively studied in Gram-negative organisms, where they have been associated with antigenic variation and other adaptation strategies. In this study, we apply comparative genomics in order to find evidence of slipped-strand mispairing in the human Gram-positive pathogen Streptococcus agalactiae. In two consecutive screenings, 2,233 (650 + 1,583) SSRs were identified in our reference genome 2603V/R, and these loci were examined in seven other S. agalactiae genomes. A total of 56 SSR loci were found to exhibit variation, where gain or loss of repeat units was observed in at least one other genome, resulting in aberrant genotypes. Homopolymeric adenine tracts predominated among the repeats that varied. Positional analysis revealed that long polyadenine tracts were overrepresented in the 5' ends of open reading frames (ORFs) and underrepresented in the 3' ends. Repeat clustering in ORFs was also examined, and the highest degree of clustering was observed for a capsule biosynthesis gene and a pilus sortase. A statistical analysis of observed over expected ratios suggested a selective pressure against long homopolymeric tracts. Altered phenotypes were verified for three genes encoding surface-attached proteins, in which frameshifts or fusions led to truncation of proteins and/or affected surface localization through loss or gain of the cell wall sorting signal. The data suggest that SSRs contributes to genome plasticity in S. agalactiae but that the bet-hedging strategy is different from Gram-negative organisms. doi: 10.1128/JB.01465-09

Published
2010

22. A second pilus type in Streptococcus pneumoniae is prevalent in emerging serotypes and mediates adhesion to host cells

Author

Bagnoli, Fabio, Moschioni, Monica, Donati, Claudio, Dimitrovska, Valentina, Ferlenghi, Ilaria, Facciotti, Claudia, Muzzi, Alessandro, Giusti, Fabiola, Emolo, Carla, Sinisi, Antonella, Hilleringmann, Markus, Pansegrau, Werner, Censini, Stefano, Rappuoli, Rino, Covacci, Antonello, Masignani, Vega, and Barocchi, Michele A.

Subjects
Streptococcus pneumoniae -- Physiological aspects, Streptococcus pneumoniae -- Genetic aspects, Bacterial genetics -- Research, Genomics -- Research, Bacteria -- Adhesion, Bacteria -- Genetic aspects, Biological sciences
Abstract

Analysis of publicly available genomes of Streptococcus pneumoniae has led to the identification of a new genomic element containing genes typical of gram-positive pilus islets (PIs). Here, we demonstrate that this genomic region, herein referred to as PI-2 (consisting of pitA, sipA, pitB, srtG1, and srtG2) codes for a second functional pilus in pneumococcus. Polymerization of the PI-2 pilus requires the backbone protein PitB as well as the sortase SrtG1 and the signal peptidase-like protein SipA. Presence of PI-2 correlates with the genotype as defined by multilocus sequence typing and clonal complex (CC). The PI-2-positive CCs are associated with serotypes 1, 2, 7F, 19A, and 19F, considered to be emerging serotypes in both industrialized and developing countries. Interestingly, strains belonging to CC271 (where sequence type 271 is the predicted founder of the CC) contain both PI-1 and PI-2, as revealed by genome analyses. In these strains both pili are surface exposed and independently assembled. Furthermore, in vitro experiments provide evidence that the pilus encoded by PI-2 of S. pneumoniae is involved in adherence. Thus, pneumococci encode at least two types of pili that play a role in the initial host cell contact to the respiratory tract and are potential antigens for inclusion in a new generation of pneumococcal vaccines.

Published
2008

27. Contributors

Author

Ackerman, Michael J., primary, Anderson, Matthew L., additional, Andreotti, Felicita, additional, Annex, Brian H., additional, Antonellis, Anthony, additional, Artemov, Dmitri, additional, Bain, James R., additional, Barnes, Peter J., additional, Barnholtz-Sloan, J.S., additional, Becker, Richard C., additional, Benjamin, Ivor J., additional, Billings, Paul R., additional, Body, Simon C., additional, Boguski, Mark, additional, Bonassi, Stefano, additional, Bondy, Brigitta, additional, Bos, J. Martijn, additional, Breitbart, Roger E., additional, Brody, Jerome, additional, Brown, Matthew P., additional, Bullinger, Lars, additional, Burgess, Shawn C., additional, Butte, Atul J., additional, Carey, David J., additional, Carlson, George, additional, Celedón, Juan C., additional, Chandrasekharan, Subhashini, additional, Chang, Wing C. (John), additional, Chen, Yan, additional, Chiocca, Antonio, additional, Chow, Theresa Puifun, additional, Chung, Wendy K., additional, Cook-Deegan, Robert, additional, Corella, Dolores, additional, Cottrell, Susan, additional, Cox, Nancy J., additional, Crawford, Nigel P.S., additional, Cuticchia, A. Jamie, additional, Deforce, Dieter, additional, Deng, Mario C., additional, Devi, Gayathri, additional, deVos, Theo, additional, Distler, Juergen, additional, Dohner, Harmut, additional, Dokun, Ayotunde O., additional, Edbrooke, Mark R., additional, Edelman, Lucas B., additional, Elewaut, Dirk, additional, Epstein, Charles J., additional, Fanous, Ayman H., additional, Febbo, Phillip G., additional, Feezor, Robert J., additional, Feng, Yonmei, additional, Földes-Papp, Zeno, additional, Fujinaka, Hidehiko, additional, Galas, David J., additional, Garrison, Louis, P., additional, Gerhard, Glenn S., additional, Ginsburg, Geoffrey S., additional, Gjertsen, Bjorn T., additional, Glass, Michael, additional, Goldstein, David B., additional, Gordon, Erynn S., additional, Gosnell, Tucker, additional, Grass, Peter, additional, Green, Eric D., additional, Grossman, Iris, additional, Gwinn, Marta, additional, Haefliger, Carolina, additional, Haga, Susanne B., additional, Hall, Per, additional, Hare, Joshua M., additional, Hariri, Ahmad, additional, Heath, James R., additional, Hegele, Robert A., additional, Heidecker, Bettina, additional, Hislop, Shona, additional, Hoffman, Eric P., additional, Holton, John, additional, Hood, Leroy, additional, Huang, Andrew T., additional, Huang, Erich S., additional, Hubbard, Carlos A., additional, Hunter, Kent, additional, Hyland, Courtney, additional, Ihm, Chunhwa, additional, Ilkayeva, Olga, additional, Irizarry, Rafael, additional, Jain, Shushant, additional, Johnson, Melissa D., additional, Kantoff, Philip W., additional, Kathiresan, Sekar, additional, Kathuria, Hasmeena, additional, Kawamoto, Kensaku, additional, Keyser, Filip De, additional, Khalid, Asif, additional, Khoury, Muin, additional, Kingsmore, Stephen F., additional, Kittleson, Michelle M., additional, Koshy, Beena T., additional, Krishnan, Ranga, additional, Krouse, Robert S., additional, Kundra, Vikas, additional, Lai-Goldman, Myla, additional, Lakhani, Vipul, additional, Langer, Robert, additional, Lawler, Sean E., additional, Lee, Inyoul, additional, Lee, Charles, additional, Lee, Arthur S., additional, Leong, Stanely, additional, Lesche, Ralf, additional, Levy, Samuel, additional, Liu, Edison T., additional, Lobach, David F., additional, Lorens, James B., additional, Lusis, Aldons J., additional, Lyerly, H. Kim, additional, Madamanchi, Nageswara R., additional, Martinez, J. Alfredo, additional, Masignani, Vega, additional, McGrath, Kevin, additional, McHutchison, John, additional, Middleton, Frank, additional, Mielants, Herman, additional, Muehlbauer, Michael J., additional, Müller-Ladner, Ulf, additional, Nelson, Mark A., additional, Neri, Monica, additional, Netea, Mihai, additional, Newby, L. Kristin, additional, Newgard, Christopher B., additional, Ng, Maggie, additional, Noble, Paul W., additional, Ntziachristos, Vasilis, additional, Nussbaum, Robert L., additional, O'Donoghue, Meghan B., additional, Odunsi, Kunle, additional, Olden, Kenneth, additional, Ommen, Steve R., additional, Ordovas, Jose M., additional, Patarca, Roberto, additional, Patel, Jeetendra, additional, Patel, K., additional, Pato, Carlos N., additional, Pato, Michele T., additional, Pejovic, Tanja, additional, Perin, Noah C., additional, Pham, Michael, additional, Plenge, Robert M., additional, Plum, Achim, additional, Podgoreanu, Mihai V., additional, Pollack, Jonathan R., additional, Pollex, Rebecca L., additional, Price, Nathan D., additional, Quertermous, Thomas, additional, Quintana, Francisco J., additional, Raby, Benjamin A., additional, Rader, Daniel J., additional, Ramaswamy, Sridhar, additional, Rammensee, Hans-Georg, additional, Ramsey, Scott D., additional, Rappuoli, Rino, additional, Rifai, Nader, additional, Rimsza, Lisa, additional, Rogers, Yu-Hui, additional, Roses, Allen D., additional, Ross, Jeffrey S., additional, Roubenoff, Ronenn, additional, Runge, Marschall S., additional, Scheuner, Maren T., additional, Schuster, Matthias, additional, Schwartz, David A., additional, Schwinn, Debra A., additional, Seng, Chia Kee, additional, Shackel, Nicholas A., additional, Shannon, M. Frances, additional, Sherry, A. Dean, additional, Shi, Jiaqi, additional, Shianna, Kevin, additional, Shnayder, Yelizaveta, additional, Singleton, Andrew B., additional, Slavin, T.P., additional, Smith, Desmond J., additional, Snoeckx, Rikkert L., additional, Snyderman, Ralph, additional, Spira, Avrum, additional, Spraggs, Colin F., additional, Stevens, Robert D., additional, Stewart, Nicolas A., additional, Stewart, Alison, additional, Stewart, F., additional, Strausberg, Robert L., additional, Szyf, Moshe, additional, Tan, Weihong, additional, Tepper, Robert I., additional, Tettelin, Hervé, additional, Thomas, Giovana R., additional, Thompson, John D., additional, Thongboonkerd, Visith, additional, Topol, Eric J., additional, Towbin, Jeffrey A., additional, Bodegraven, Ad A. van, additional, Van Den Bogaert, Kris, additional, Van den Bosch, Filip, additional, Vatta, Matte, additional, Veenstra, Timothy D., additional, Veenstra, David L., additional, Vendrov, Aleksandr E., additional, Verfaillie, Catherine M., additional, Walley, Nicole M., additional, Wang, Ling, additional, Weale, Mike, additional, Weinblatt, Michael E., additional, Weiner, Howard L., additional, Weiss, Scott T., additional, Weissleder, Ralph, additional, Wells, Samuel A., additional, Wenner, Brett R., additional, Wiechers, Ilse R., additional, Wiesner, Georgia L., additional, Wiggs, Janey L., additional, Wijmenga, Cisca, additional, Willard, Huntington F., additional, Wilson, James M., additional, Wivel, Nelson A., additional, Wohlgemuth, Jay, additional, Woodcock, Janet, additional, Woods, Christopher W., additional, Woon, Paula W., additional, Yagil, Chana, additional, Yagil, Yoram, additional, Yamamoto, Tadashi, additional, Yao, Gang, additional, Yee, Andrew J., additional, Yoo, Hyuntae, additional, You, Y. Nancy, additional, Yu, Li-Rong, additional, Zagury, Jean-François, additional, Zimmern, Ron, additional, and Züchner, Stephan, additional

Published
2009
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30. 4CMenB vaccine induces elite cross-protective human antibodies that compete with human factor H for binding to meningococcal fHbp

Author

Veggi, Daniele, primary, Bianchi, Federica, additional, Santini, Laura, additional, Lo Surdo, Paola, additional, Chesterman, Chelsy C., additional, Pansegrau, Werner, additional, Bechi, Nicoletta, additional, Huang, Ying, additional, Masignani, Vega, additional, Pizza, Mariagrazia, additional, Rappuoli, Rino, additional, Bottomley, Matthew J., additional, Cozzi, Roberta, additional, and Maione, Domenico, additional

Published
2020
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31. Approaches to Target Conserved Conformational Epitopes in HIV Envelope

Author

Rappuoli Rino, Srivastava Ranjana, Megede Jan, Masignani Vega, Capecchi Barbara, Martin Erick, Vita Claudio, Zuckermann Ron, Connolly Michael, Lian Ying, Sun Yide, Kan Elaine, Sharma Victoria, Srivastava Indresh K, Donnelly John, Ulmer Jeffrey B, and Barnett Susan W

Subjects
Immunologic diseases. Allergy, RC581-607
Published
2005
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32. Contributors

Author

Acharya, K. Ravi, primary, Acquadro, Martin A., additional, Aktories, Klaus, additional, Alouf, Joseph E., additional, Arnold, Ralf, additional, Babon, Aurélie, additional, Backert, Steffen, additional, Baker, Matthew D., additional, Barbieri, Joseph T., additional, Basak, Ajit K., additional, Bast, Darrin J., additional, Billington, Stephen J., additional, Bohnert, Stephanie, additional, Boquet, Patrice, additional, Borodic, Gary E., additional, Braun, Volkmar, additional, Bryant, Amy E., additional, Carniol, Karen, additional, Carnoy, Christophe, additional, Chenal, Alexandre, additional, Cole, Ambrose, additional, Colin, Didier A., additional, Collier, John, additional, Cover, Timothy L., additional, Dalla Serra, Mauro, additional, de Azavedo, Joyce C.S., additional, Deinhardt, Kartrin, additional, Dobrindt, Ulrich, additional, D'Souza, Jocelyne M., additional, Dubreuil, Daniel, additional, Feil, Susanne C., additional, Flateau, Gilles, additional, Fournier, Bénédicte, additional, Franco, Augusto A., additional, Frank, Dara W., additional, Fraser, John D., additional, Frey, Joachim, additional, Frisan, Teresa, additional, Galmiche, Antoine, additional, Gauthier, Michel, additional, Giddings, Kara S., additional, Gillet, Daniel, additional, Gilmore, Michael S., additional, Goebel, Werner, additional, Granum, Per Einar, additional, Gurcel, Laure, additional, Hacker, Jörg, additional, Hertle, Ralf, additional, Hirst, Timothy R., additional, Ho, Mangfei, additional, Holmes, Randall K., additional, Holmgren, Jan, additional, Horiguchi, Yasuhiko, additional, Iacovache, Ioan, additional, Imanishi, Ken-ichi, additional, Johannes, Ludger, additional, Johnson, Arthur E., additional, Johnson, Eric A., additional, Jost, B. Helen, additional, Just, Ingo, additional, Kato, Hidehito, additional, König, Wolfgang, additional, König, Brigitte, additional, Lacharme, Lizeth, additional, Ladhani, Shamez N., additional, Lamaze, Christophe, additional, Lemaitre, Nadine, additional, Lemichez, Emmanuel, additional, Leppla, Stephen, additional, Lereclus, Didier, additional, Liu, George, additional, Locht, Camille, additional, Ludwig, Albrecht, additional, Mahillon, Jacques, additional, Maresso, Anthony W., additional, Masignani, Vega, additional, Masin, Jiri, additional, McClain, Mark, additional, McClane, Bruce, additional, Mekada, Eisuke, additional, Melton, Jody, additional, Menestrina, Gianfranco†, additional, Ménez, André, additional, Michelet, Nathalie, additional, Mitchell, Tim J., additional, Miyoshi, Shin-ichi, additional, Miyoshi-Akiyama, Tohru, additional, Molgo, Jordi, additional, Monteil, Henri, additional, Mourey, Lionel, additional, Müller-Alouf, Heide, additional, Nizet, Victor, additional, Ölschläger, Tobias, additional, Olsnes, Sjur, additional, Oram, Diana Marra, additional, Parker, Michael W., additional, Perier, Aurélie, additional, Pizza, Mariagrazia, additional, Polekhina, Galina, additional, Popoff, Michel R., additional, Poulain, Bernard, additional, Prévost, Gilles, additional, Proft, Thomas, additional, Rappuoli, Rino, additional, Rood, Julian I., additional, Rossjohn, Jamie, additional, Rupnik, Maha, additional, Salim, Kowthar Y., additional, Salinas, Sara, additional, Sandkvist, Maria, additional, Sandvig, Kirsten, additional, Schiavo, Giampetro, additional, Scortti, Mariela, additional, Scott, Maria E., additional, Sears, Cynthia L., additional, Sebo, Peter, additional, Shinoda, Sumio, additional, Simonet, Michel, additional, Smith, Leonard A., additional, Stachowiak, Radek, additional, Stevens, Dennis L., additional, Stiles, Bradley G., additional, Svennerholm, Ann-Mari, additional, Tang, Julian, additional, Thelestam, Monica, additional, Titball, Richard W., additional, Tweten, Rodney K., additional, Uchiyama, Takehiko, additional, van der Goot, F. Gisou, additional, Vásquez-Boland, José A., additional, Wesche, Jørgen, additional, Wilson, Brenda Anne, additional, and Wu, Shaoguang, additional

Published
2006
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34. Vaccines against Pathogenic Streptococci

Author

Telford, John L., primary, Ros, Immaculada Margarit Y, additional, Maione, Domenico, additional, Masignani, Vega, additional, Tettelin, Hervé, additional, Bensi, Giuliano, additional, and Grandi, Guido, additional

Published
2005
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35. Phylogeny of the SARS Coronavirus

Author

Eickmann, Markus, Becker, Stephan, Klenk, Hans-Dieter, Doerr, Hans Wilhelm, Stadler, Konrad, Censini, Stefano, Guidotti, Silvia, Masignani, Vega, Scarselli, Maria, Mora, Marirosa, Donati, Claudio, Han, Jang H., Song, Hyun Chul, Abrignani, Sergio, Covacci, Antonello, and Rappuoli, Rino

Published
2003

38. CONTRIBUTORS

Author

Aseffa, Abraham, primary, Ballou, W. Ripley, additional, Batson, Amie, additional, Best, Jennifer M., additional, Birmingham, Maureen, additional, Bjorvatn, Bjarne, additional, Bloom, Barry R., additional, Bresee, Joseph S., additional, Choi, Elisa I., additional, Clemens, John D., additional, Del Giudice, Giuseppe, additional, de Quadros, Ciro A., additional, Finlay, B. Brett, additional, Gentsch, Jon, additional, Gissmann, Lutz, additional, Glass, Roger I., additional, Glass, Sarah, additional, Greenwood, Brian, additional, Gumy, Alain, additional, Hackell, Jill G., additional, Halsey, Neal A., additional, Hoffman, Stephen L., additional, Koo, Hye-Won, additional, Lambert, Paul-Henri, additional, Launois, Pascal, additional, Letvin, Norman L., additional, Levine, Ruth E., additional, Louis, Jacques A., additional, Macklin, Ruth, additional, Mascola, John R., additional, Masignani, Vega, additional, Miller, Elizabeth, additional, Mulholland, Edward Kim, additional, O'shea, Siobhan, additional, Parashar, Umesh, additional, Pizza, Mariagrazia, additional, Plotkin, Stanley A., additional, Rappuoli, Rino, additional, Richie, Thomas L., additional, Röcken, Martin, additional, Salmaso, Stefania, additional, Seder, Robert A., additional, Seiguer, Erica, additional, Siegrist, Claire-Anne, additional, Stein, Claudia, additional, Tacchini-Cottier, Fabienne, additional, Tuomanen, Elaine I., additional, Voigt, Heike, additional, Weiser, Jeffrey N., additional, Young, Douglas B., additional, and Zinkernagel, Rolf M., additional

Published
2003
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42. Design, synthesis, computational studies, and homodimerization of polymethelylene-bridged resorc(4)arenes

Author

Botta, Bruno, Monache, Giuliano Delle, De Rosa, M. Cristina, Seri, Catia, Benedetti, Ettore, Iacovino, Rosa, Botta, Maurizio, Corelli, Federico, Masignani, Vega, Tafi, Andrea, Gacs-Baitz, Eszter, Santini, Antonello, and Misiti, Domenico

Subjects
Aromatic compounds, Molecular structure -- Research, Biological sciences, Chemistry
Abstract

The synthesis and characterization of polymethylene-bridged resorc(4)arenes are described. The scheme involves the reaction of tetraalcohol with glutaroyl, adipoyl and pimeloyl dichlorides in the presence of ET3N to form the corresponding double-spanned calix(4)resorcarenes. Insertion of two polymethylene bridges affords to target compounds. The compounds were characterized by NMR, X-ray and molecular dynamic analysis.

Published
1997

46. Structural basis for cooperativity of human monoclonal antibodies to meningococcal factor H-binding protein

Author

Novartis, European Commission, Peschiera, Ilaria, Giuliani, Maria, Giusti, Fabiola, Melero, Roberto, Paccagnini, Eugenio, Donnarumma, Danilo, Pansegrau, Werner, Carazo, José M., Sorzano, Carlos Óscar S., Scarselli, María, Masignani, Vega, Liljeroos, Lassi J., Ferlenghi, Ilaria, Novartis, European Commission, Peschiera, Ilaria, Giuliani, Maria, Giusti, Fabiola, Melero, Roberto, Paccagnini, Eugenio, Donnarumma, Danilo, Pansegrau, Werner, Carazo, José M., Sorzano, Carlos Óscar S., Scarselli, María, Masignani, Vega, Liljeroos, Lassi J., and Ferlenghi, Ilaria

Abstract

Monoclonal antibody (mAb) cooperativity is a phenomenon triggered when mAbs couples promote increased bactericidal killing compared to individual partners. Cooperativity has been deeply investigated among mAbs elicited by factor H-binding protein (fHbp), a Neisseria meningitidis surface-exposed lipoprotein and one of the key antigens included in both serogroup B meningococcus vaccine Bexsero and Trumenba. Here we report the structural and functional characterization of two cooperative mAbs pairs isolated from Bexsero vaccines. The 3D electron microscopy structures of the human mAb–fHbp–mAb cooperative complexes indicate that the angle formed between the antigen binding fragments (fAbs) assume regular angle and that fHbp is able to bind simultaneously and stably the cooperative mAbs pairs and human factor H (fH) in vitro. These findings shed light on molecular basis of the antibody-based mechanism of protection driven by simultaneous recognition of the different epitopes of the fHbp and underline that cooperativity is crucial in vaccine efficacy.

Published
2019

48. NarE: a novel ADP-ribosyltransferase from Neisseria meningitidis

Author

Masignani, Vega, Balducci, Enrico, Di Marcello, Federica, Savino, Silvana, Serruto, Davide, Veggi, Daniele, Bambini, Stefania, Scarselli, Maria, Aricò, Beatrice, Comanducci, Maurizio, Adu-Bobie, Jeannette, Giuliani, Marzia M., Rappuoli, Rino, and Pizza, Mariagrazia

Published
2003

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