Search

Your search keyword '"Masip, Jenifer' showing total 24 results
Start Over Author "Masip, Jenifer
24 results on '"Masip, Jenifer'

1. Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events

Author

Jarrín, Inma, Dalmau, David, Navarro, M. Luisa, González, M. Isabel, Garcia, Federico, Poveda, Eva, Iribarren, Jose Antonio, Gutiérrez, Félix, Rubio, Rafael, Vidal, Francesc, Berenguer, Juan, González, Juan, Muñoz-Fernández, M. Ángeles, Jarrín, Inmaculada, Moreno, Cristina, Rava, Marta, Izquierdo, Rebeca, Mauleón, Elba, Portilla, Joaquín, Portilla, Irene, Merino, Esperanza, García, Gema, Agea, Iván, Sánchez-Payá, José, Rodríguez, Juan Carlos, Giner, Livia, Reus, Sergio, Boix, Vicente, Torrus, Diego, Pérez, Verónica, Portilla, Julia, Gómez, Juan Luís, Hernández, Jehovana, Lirola, Ana López, García, Dácil, Díaz-Flores, Felicitas, Alonso, M. Mar, Pelazas, Ricardo, Alemán, M. Remedios, Asensi, Víctor, Rivas Carmenado, María Eugenia, Suarez-Zarracina, Tomás, Pulido, Federico, Bisbal, Otilia, Hernando, M. Asunción, Rial, David, de Lagarde, María, Arce, Octavio, Pinto, Adriana, Bermejo, Laura, Santacreu, Mireia, Navarro, Roser, Gonzalez, Candela, Aramburu, M. José, Camino, Xabier, Ángel von Wichmann, Miguel, Goenaga, Miguel Ángel, Bustinduy, M. Jesús, Azkune, Harkaitz, Ibarguren, Maialen, Kortajarena, Xabier, Álvarez-Rodriguez, Ignacio, Gil, Leire, Martínez, Lourdes, Robledano, Catalina, Masiá, Mar, Padilla, Sergio, Adsuar, Araceli, Pascual, Rafael, Fernández, Marta, Galiana, Antonio, García, José Alberto, Barber, Xavier, Agullo, Vanessa, Abellán, Javier Garcia, Pascual, Reyes, Telenti, Guillermo, Guillén, Lucia, Botella, Ángela, Muga, Roberto, Sanvisens, Arantza, Fuster, Daniel, Gutierrez, Isabel, López, Juan Carlos, Ramírez, Margarita, Padilla, Belén, Gijón, Paloma, Aldamiz-Echevarría, Teresa, Tejerina, Francisco, Diez, Cristina, Pérez, Leire, Fanciulli, Chiara, Corral, Saray, Martí, Anna, Peraire, Joaquín, Viladés, Consuelo, Vargas, Montserrat, Olona, Montserrat, Rull, Anna, Alba, Verónica, Yeregui, Elena, Masip, Jenifer, García-Pardo, Graciano, Bertomeu, Frederic Gómez, Espineira, Sonia, Montero, Marta, Cuéllar, Sandra, Blanes, Marino, Tasias, María, Calabuig, Eva, Salavert, Miguel, Fernández, Juan, Segarra, Inmaculada, González-García, Juan, Delgado, Ana, Arnalich, Francisco, Arribas, José Ramón, Bernardino, Jose Ignacio, Castro, Juan Miguel, Escosa, Luis, Herranz, Pedro, Hontañón, Victor, García-Bujalance, Silvia, García, Milagros, González-Baeza, Alicia, Martín-Carbonero, M. Luz, Mayoral, Mario, Mellado, M. Jose, Esteban, Rafael, Montejano, Rocío, Montes, M. Luisa, Moreno, Victoria, Pérez-Valero, Ignacio, Rodés, Berta, Rúa, Guadalupe, Sainz, Talía, Sendagorta, Elena, Valencia, Eulalia, Busca, Carmen, Cano, Joanna, Cardiñanos, Julen, de Miguel, Rosa, Blanco, Jose Ramón, Pérez-Martínez, Laura, Oteo, José Antonio, Ibarra, Valvanera, Metola, Luis, Sanz, Mercedes, Arazo, Piedad, Sampériz, Gloria, Martinez, Marina, Jaén, Angels, Sanmartí, Montse, Cairó, Mireia, Martinez-Lacasa, Javier, Velli, Pablo, Font, Roser, Xercavins, Mariona, Alonso, Noemí, Aiello, Francesco, Rivero, María, Piérola, Beatriz, Goikoetxea, Maider, Gracia, María, Ibero, Carlos, Moreno, Estela, Repáraz, Jesús, Navarro, Gemma, Garcia, Manel Cervantes, Isbert, Sonia Calzado, Vilasaro, Marta Navarro, Garcia, Belen Lopez, Santos, Ignacio de los, Santos, Alejandro de los, Sanz, Jesús, García-Fraile, Lucio, Martín, Enrique, Sánchez-Cerrillo, Ildefonso, Calvet, Marta, Barrios, Ana, Bautista, Azucena, Sáez, Carmen, Ciudad, Marianela, Gutiérrez, Ángela, Moreno, Santiago, Campo, Santos del, Casado, José Luis, Dronda, Fernando, Moreno, Ana, Pérez, M. Jesús, Serrano, Sergio, Vivancos, M<ce:sup loc='post">a</ce:sup> Jesús, Martínez-Sanz, Javier, Vallejo, Alejandro, Sanchez, Matilde, Pérez-Molina, Jose Antonio, Hermida, José Manuel, Bernal, Enrique, Alcaraz, Antonia, Bravo, Joaquín, Muñoz, Ángeles, Tomás, Cristina, Martínez, Mónica, Villalba, M. Carmen, García, Federico, Martínez, Clara, Hernández, José, Medina, Leopoldo Muñoz, Álvarez, Marta, Chueca, Natalia, Vinuesa, David, de Salazar, Adolfo, Fuentes, Ana, Guirao, Emilio, Viñuela, Laura, Ruiz-Sancho, Andrés, Anguita, Francisco, Del Romero, Jorge, Raposo, Montserrat, Rodríguez, Carmen, Puerta, Teresa, Carrió, Juan Carlos, Vera, Mar, Ballesteros, Juan, Ayerdi, Oskar, Baza, Begoña, Orviz, Eva, Antela, Antonio, Losada, Elena, Riera, Melchor, Peñaranda, María, Ribas, M. Angels, Campins, Antoni A., Garcia-Gazalla, Mercedes, Fanjul, Francisco J., Murillas, Javier, Homar, Francisco, Vilchez, Helem H., Martin, Luisa, Payeras, Antoni, Santos, Jesús, López, María, Gómez, Crisitina, Viciana, Isabel, Palacios, Rosario, López-Cortés, Luis Fernando, Espinosa, Nuria, Roca, Cristina, Llaves, Silvia, Tiraboschi, Juan Manuel, Imaz, Arkaitz, Silva, Ana Karina, Saumoy, María, Scévola, Sofía Catalina, Curran, Adrián, Falcó, Vicenç, Navarro, Jordi, Burgos, Joaquin, Suanzes, Paula, García, Jorge, Descalzo, Vicente, Álvarez, Patricia, Planas, Bibiana, Sanchiz, Marta, Rodríguez, Lucía, Olalla, Julián, Sánchez, M José, Pérez, Javier, Arco, Alfonso del, Torre, Javier de la, Prada, José Luis, Martínez, Onofre Juan, Martinez, Lorena, Vera, Francisco Jesús, García, Josefina, Alcaraz, Begoña, Sánchez Guirao, Antonio Jesús, Mena, Alvaro, Castro, Angeles, Pernas, Berta, Vázquez, Pilar, López, Soledad, Ibarra, Sofía, García, Guillermo, Mirena, Josu, Ferrero, Oscar Luis, López, Josefina, Cámara, M. Mar, Peña, Mireia de la, Lopez, Miriam, Lopez, Iñigo, Lombide, Itxaso, Polo, Victor, de Miguel, Joana, Galera, Carlos, Fernández, Marian, Albendin, Helena, Castillo, Antonia, Iborra, Asunción, Moreno, Antonio, Merlos, M. Angustias, Vidal, Asunción, Amador, Concha, Pasquau, Francisco, Gil, Concepcion, Algado, Jose Tomás, Suarez-García, Inés, Malmierca, Eduardo, González-Ruano, Patricia, Ruiz, M. Pilar, Pascual, José Francisco, Sáez, Elena, Balsalobre, Luz, López, M. Villa, Omar, Mohamed, Herrero, Carmen, Gómez, M. Amparo, Alberto de Zarraga, Miguel, Pérez, Desiré, Estrada, Vicente, Sanz, Nieves, Cabello, Noemí, García, Jorge Vergas, Núñez, Maria Jose, Sagastagoitia, Iñigo, Górgolas, Miguel, Cabello, Alfonso, Álvarez, Beatriz, Prieto, Laura, Carrillo, Irene, Sanz, José, Arranz, Alberto, Hernández, Cristina, Novella, María, Galindo, M. José, Ferrer, Ana, Román, Antonio Rivero, Ruíz, Inma, Juárez, Antonio Rivero, López, Pedro, Machuca, Isabel, Frias, Mario, Camacho, Ángela, Pérez, Ignacio, Corona, Diana, Cervero, Miguel, Torres, Rafael, Pineda, Juan Antonio, Rincón, Pilar, Macías, Juan, Real, Luis Miguel, Corma, Anais, Gonzalez-Serna, Alejandro, Pérez, Alexandre, Morano, Luis, Miralles, Celia, Ocampo, Antonio, Pousada, Guillermo, Patiño, Lucía, Dueñas, Carlos, Gutiérrez, Sara, Tapia, Elena, Novoa, Cristina, Egües, Xjoylin, Telleria, Pablo, Díaz-Álvarez, Jorge, Rosas Cancio-Suarez, Marta, Ron, Raquel, Iribarren, José Antonio, Ruiz Sancho, Andrés, Cabello, Noemi, and Serrano-Villar, Sergio

Published
2023
Full Text
View/download PDF

2. High circulating SDF-1and MCP-1 levels and genetic variations in CXCL12, CCL2 and CCR5: Prognostic signature of immune recovery status in treated HIV-positive patients

Author

Yeregui, Elena, Viladés, Consuelo, Domingo, Pere, Ceausu, Andra, Pacheco, Yolanda María, Veloso, Sergi, Inciarte, Alexy, Vidal-González, Judit, Peraire, Maria, Perpiñán, Carles, Falcó, Vicenç, Masip, Jenifer, Alba, Verónica, Vargas, Montserrat, Martí, Anna, Reverté, Laia, Mallolas, Josep, Vidal, Francesc, Peraire, Joaquim, and Rull, Anna

Published
2020
Full Text
View/download PDF

3. Elevated α-Ketoglutaric Acid Concentrations and a Lipid-Balanced Signature Are the Key Factors in Long-Term HIV Control

Author

Jenifer Masip, Norma Rallón, Elena Yeregui, Montserrat Olona, Salvador Resino, José M. Benito, Consuelo Viladés, Graciano García-Pardo, José Alcamí, Ezequiel Ruiz-Mateos, Frederic Gómez-Bertomeu, Montserrat Vargas, Marta Navarro, José A. Oteo, Juan A. Pineda, Anna Martí, Verónica Alba, Francesc Vidal, Joaquin Peraire, and Anna Rull

Subjects
metabolomics, lipidomics, elite controllers (ECs), HIV infection, Kreb's cycle, long-term, Immunologic diseases. Allergy, RC581-607
Abstract

Long-term elite controllers (LTECs) are a fascinating small subset of HIV individuals with viral and immunological HIV control in the long term that have been designated as models of an HIV functional cure. However, data on the LTEC phenotype are still scarce, and hence, the metabolomics and lipidomics signatures in the LTEC-extreme phenotype, LTECs with more than 10 years of viral and immunological HIV control, could be pivotal to finding the keys for functional HIV remission. Metabolomics and lipidomics analyses were performed using high-resolution mass spectrometry (ultra-high-performance liquid chromatography–electrospray ionization–quadrupole time of flight [UHPLC-(ESI) qTOF] in plasma samples of 13 patients defined as LTEC-extreme, a group of 20 LTECs that lost viral and/or immunological control during the follow-up study (LTEC-losing) and 9 EC patients with short-term viral and immunological control (less than 5 years; no-LTEC patients). Long-term viral and immunological HIV-1 control was found to be strongly associated with elevated tricarboxylic acid (TCA) cycle function. Interestingly, of the nine metabolites identified in the TCA cycle, α-ketoglutaric acid (p = 0.004), a metabolite implicated in the activation of the mTOR complex, a modulator of HIV latency and regulator of several biological processes, was found to be a key metabolite in the persistent control. On the other hand, a lipidomics panel combining 45 lipid species showed an optimal percentage of separation and an ability to differentiate LTEC-extreme from LTEC-losing, revealing that an elevated lipidomics plasma profile could be a predictive factor for the reignition of viral replication in LTEC individuals.

Published
2022
Full Text
View/download PDF

4. Evolution of Serum Acute-Phase Glycoproteins Assessed by 1H-NMR in HIV Elite Controllers

Author

Ana-Irene Malo, Joaquim Peraire, Ezequiel Ruiz-Mateos, Jenifer Masip, Núria Amigó, José Alcamí, Santiago Moreno, Josefa Girona, Graciano García-Pardo, Rosaura Reig, Francesc Vidal, Antoni Castro, Lluís Masana, and Anna Rull

Subjects
elite controllers, HIV, inflammation, acute-phase glycoproteins, proton nuclear magnetic resonance, Immunologic diseases. Allergy, RC581-607
Abstract

Elite controllers (ECs) are an exceptional group of people living with HIV (PLWH) who maintain undetectable viral loads (VLs) despite not being on antiretroviral therapy (ART). However, this phenotype is heterogeneous, with some of these subjects losing virological control over time. In this longitudinal retrospective study, serum acute-phase glycoprotein profile assessed by proton nuclear magnetic resonance (1H-NMR) was determined in 11 transient controllers (TCs) who spontaneously lost virological control and 11 persistent controllers (PCs) who persistently maintained virological control over time. Both PCs and TCs showed similar acute-phase glycoprotein profiles, even when TCs lost the virological control (GlycB, p = 0.824 and GlycA, p = 0.710), and the serum acute-phase glycoprotein signature in PCs did not differ from that in HIV-negative subjects (GlycB, p = 0.151 and GlycA, p = 0.243). Differences in serum glycoproteins A and B were significant only in ECs compared to HIV-typical progressors (TPs) with < 100 CD4+ T-cells (p < 0.001). 1H-NMR acute-phase glycoprotein profile does not distinguish TCs form PCs before the loss of viral control. ECs maintain a low-grade inflammatory state compared to TPs. PCs revealed a closer serum signature to HIV-negative subjects, reaffirming this phenotype as a closer model of functional control of HIV.

Published
2021
Full Text
View/download PDF

5. Differential miRNA plasma profiles associated with the spontaneous loss of HIV‐1 control: miR‐199a‐3p and its potential role as a biomarker for quick screening of elite controllers

Author

Jenifer Masip, Carmen Gasca‐Capote, María Reyes Jimenez‐Leon, Joaquim Peraire, Alberto Perez‐Gomez, Verónica Alba, Ana‐Irene Malo, Lorna Leal, Carmen Rodríguez Martín, Norma Rallón, Consuelo Viladés, Montserrat Olona, Francesc Vidal, Ezequiel Ruiz‐Mateos, Anna Rull, and ECRIS integrated in the Spanish AIDS Research Network (Annex S1)

Subjects
Medicine (General), R5-920
Published
2021
Full Text
View/download PDF

6. Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events

Author

Martínez-Sanz, Javier, primary, Díaz-Álvarez, Jorge, additional, Rosas Cancio-Suarez, Marta, additional, Ron, Raquel, additional, Iribarren, José Antonio, additional, Bernal, Enrique, additional, Gutiérrez, Félix, additional, Ruiz Sancho, Andrés, additional, Cabello, Noemi, additional, Olalla, Julián, additional, Moreno, Santiago, additional, Serrano-Villar, Sergio, additional, Jarrín, Inma, additional, Dalmau, David, additional, Navarro, M. Luisa, additional, González, M. Isabel, additional, Garcia, Federico, additional, Poveda, Eva, additional, Iribarren, Jose Antonio, additional, Rubio, Rafael, additional, Vidal, Francesc, additional, Berenguer, Juan, additional, González, Juan, additional, Muñoz-Fernández, M. Ángeles, additional, Jarrín, Inmaculada, additional, Moreno, Cristina, additional, Rava, Marta, additional, Izquierdo, Rebeca, additional, Mauleón, Elba, additional, Portilla, Joaquín, additional, Portilla, Irene, additional, Merino, Esperanza, additional, García, Gema, additional, Agea, Iván, additional, Sánchez-Payá, José, additional, Rodríguez, Juan Carlos, additional, Giner, Livia, additional, Reus, Sergio, additional, Boix, Vicente, additional, Torrus, Diego, additional, Pérez, Verónica, additional, Portilla, Julia, additional, Gómez, Juan Luís, additional, Hernández, Jehovana, additional, Lirola, Ana López, additional, García, Dácil, additional, Díaz-Flores, Felicitas, additional, Alonso, M. Mar, additional, Pelazas, Ricardo, additional, Alemán, M. Remedios, additional, Asensi, Víctor, additional, Rivas Carmenado, María Eugenia, additional, Suarez-Zarracina, Tomás, additional, Pulido, Federico, additional, Bisbal, Otilia, additional, Hernando, M. Asunción, additional, Rial, David, additional, de Lagarde, María, additional, Arce, Octavio, additional, Pinto, Adriana, additional, Bermejo, Laura, additional, Santacreu, Mireia, additional, Navarro, Roser, additional, Gonzalez, Candela, additional, Aramburu, M. José, additional, Camino, Xabier, additional, Ángel von Wichmann, Miguel, additional, Goenaga, Miguel Ángel, additional, Bustinduy, M. Jesús, additional, Azkune, Harkaitz, additional, Ibarguren, Maialen, additional, Kortajarena, Xabier, additional, Álvarez-Rodriguez, Ignacio, additional, Gil, Leire, additional, Martínez, Lourdes, additional, Robledano, Catalina, additional, Masiá, Mar, additional, Padilla, Sergio, additional, Adsuar, Araceli, additional, Pascual, Rafael, additional, Fernández, Marta, additional, Galiana, Antonio, additional, García, José Alberto, additional, Barber, Xavier, additional, Agullo, Vanessa, additional, Abellán, Javier Garcia, additional, Pascual, Reyes, additional, Telenti, Guillermo, additional, Guillén, Lucia, additional, Botella, Ángela, additional, Muga, Roberto, additional, Sanvisens, Arantza, additional, Fuster, Daniel, additional, Gutierrez, Isabel, additional, López, Juan Carlos, additional, Ramírez, Margarita, additional, Padilla, Belén, additional, Gijón, Paloma, additional, Aldamiz-Echevarría, Teresa, additional, Tejerina, Francisco, additional, Diez, Cristina, additional, Pérez, Leire, additional, Fanciulli, Chiara, additional, Corral, Saray, additional, Martí, Anna, additional, Peraire, Joaquín, additional, Viladés, Consuelo, additional, Vargas, Montserrat, additional, Olona, Montserrat, additional, Rull, Anna, additional, Alba, Verónica, additional, Yeregui, Elena, additional, Masip, Jenifer, additional, García-Pardo, Graciano, additional, Bertomeu, Frederic Gómez, additional, Espineira, Sonia, additional, Montero, Marta, additional, Cuéllar, Sandra, additional, Blanes, Marino, additional, Tasias, María, additional, Calabuig, Eva, additional, Salavert, Miguel, additional, Fernández, Juan, additional, Segarra, Inmaculada, additional, González-García, Juan, additional, Delgado, Ana, additional, Arnalich, Francisco, additional, Arribas, José Ramón, additional, Bernardino, Jose Ignacio, additional, Castro, Juan Miguel, additional, Escosa, Luis, additional, Herranz, Pedro, additional, Hontañón, Victor, additional, García-Bujalance, Silvia, additional, García, Milagros, additional, González-Baeza, Alicia, additional, Martín-Carbonero, M. Luz, additional, Mayoral, Mario, additional, Mellado, M. Jose, additional, Esteban, Rafael, additional, Montejano, Rocío, additional, Montes, M. Luisa, additional, Moreno, Victoria, additional, Pérez-Valero, Ignacio, additional, Rodés, Berta, additional, Rúa, Guadalupe, additional, Sainz, Talía, additional, Sendagorta, Elena, additional, Valencia, Eulalia, additional, Busca, Carmen, additional, Cano, Joanna, additional, Cardiñanos, Julen, additional, de Miguel, Rosa, additional, Blanco, Jose Ramón, additional, Pérez-Martínez, Laura, additional, Oteo, José Antonio, additional, Ibarra, Valvanera, additional, Metola, Luis, additional, Sanz, Mercedes, additional, Arazo, Piedad, additional, Sampériz, Gloria, additional, Martinez, Marina, additional, Jaén, Angels, additional, Sanmartí, Montse, additional, Cairó, Mireia, additional, Martinez-Lacasa, Javier, additional, Velli, Pablo, additional, Font, Roser, additional, Xercavins, Mariona, additional, Alonso, Noemí, additional, Aiello, Francesco, additional, Rivero, María, additional, Piérola, Beatriz, additional, Goikoetxea, Maider, additional, Gracia, María, additional, Ibero, Carlos, additional, Moreno, Estela, additional, Repáraz, Jesús, additional, Navarro, Gemma, additional, Garcia, Manel Cervantes, additional, Isbert, Sonia Calzado, additional, Vilasaro, Marta Navarro, additional, Garcia, Belen Lopez, additional, Santos, Ignacio de los, additional, Santos, Alejandro de los, additional, Sanz, Jesús, additional, García-Fraile, Lucio, additional, Martín, Enrique, additional, Sánchez-Cerrillo, Ildefonso, additional, Calvet, Marta, additional, Barrios, Ana, additional, Bautista, Azucena, additional, Sáez, Carmen, additional, Ciudad, Marianela, additional, Gutiérrez, Ángela, additional, Campo, Santos del, additional, Casado, José Luis, additional, Dronda, Fernando, additional, Moreno, Ana, additional, Pérez, M. Jesús, additional, Serrano, Sergio, additional, Vivancos, Ma Jesús, additional, Martínez-Sanz, Javier, additional, Vallejo, Alejandro, additional, Sanchez, Matilde, additional, Pérez-Molina, Jose Antonio, additional, Hermida, José Manuel, additional, Alcaraz, Antonia, additional, Bravo, Joaquín, additional, Muñoz, Ángeles, additional, Tomás, Cristina, additional, Martínez, Mónica, additional, Villalba, M. Carmen, additional, García, Federico, additional, Martínez, Clara, additional, Hernández, José, additional, Medina, Leopoldo Muñoz, additional, Álvarez, Marta, additional, Chueca, Natalia, additional, Vinuesa, David, additional, de Salazar, Adolfo, additional, Fuentes, Ana, additional, Guirao, Emilio, additional, Viñuela, Laura, additional, Ruiz-Sancho, Andrés, additional, Anguita, Francisco, additional, Del Romero, Jorge, additional, Raposo, Montserrat, additional, Rodríguez, Carmen, additional, Puerta, Teresa, additional, Carrió, Juan Carlos, additional, Vera, Mar, additional, Ballesteros, Juan, additional, Ayerdi, Oskar, additional, Baza, Begoña, additional, Orviz, Eva, additional, Antela, Antonio, additional, Losada, Elena, additional, Riera, Melchor, additional, Peñaranda, María, additional, Ribas, M. Angels, additional, Campins, Antoni A., additional, Garcia-Gazalla, Mercedes, additional, Fanjul, Francisco J., additional, Murillas, Javier, additional, Homar, Francisco, additional, Vilchez, Helem H., additional, Martin, Luisa, additional, Payeras, Antoni, additional, Santos, Jesús, additional, López, María, additional, Gómez, Crisitina, additional, Viciana, Isabel, additional, Palacios, Rosario, additional, López-Cortés, Luis Fernando, additional, Espinosa, Nuria, additional, Roca, Cristina, additional, Llaves, Silvia, additional, Tiraboschi, Juan Manuel, additional, Imaz, Arkaitz, additional, Silva, Ana Karina, additional, Saumoy, María, additional, Scévola, Sofía Catalina, additional, Curran, Adrián, additional, Falcó, Vicenç, additional, Navarro, Jordi, additional, Burgos, Joaquin, additional, Suanzes, Paula, additional, García, Jorge, additional, Descalzo, Vicente, additional, Álvarez, Patricia, additional, Planas, Bibiana, additional, Sanchiz, Marta, additional, Rodríguez, Lucía, additional, Sánchez, M José, additional, Pérez, Javier, additional, Arco, Alfonso del, additional, Torre, Javier de la, additional, Prada, José Luis, additional, Martínez, Onofre Juan, additional, Martinez, Lorena, additional, Vera, Francisco Jesús, additional, García, Josefina, additional, Alcaraz, Begoña, additional, Sánchez Guirao, Antonio Jesús, additional, Mena, Alvaro, additional, Castro, Angeles, additional, Pernas, Berta, additional, Vázquez, Pilar, additional, López, Soledad, additional, Ibarra, Sofía, additional, García, Guillermo, additional, Mirena, Josu, additional, Ferrero, Oscar Luis, additional, López, Josefina, additional, Cámara, M. Mar, additional, Peña, Mireia de la, additional, Lopez, Miriam, additional, Lopez, Iñigo, additional, Lombide, Itxaso, additional, Polo, Victor, additional, de Miguel, Joana, additional, Galera, Carlos, additional, Fernández, Marian, additional, Albendin, Helena, additional, Castillo, Antonia, additional, Iborra, Asunción, additional, Moreno, Antonio, additional, Merlos, M. Angustias, additional, Vidal, Asunción, additional, Amador, Concha, additional, Pasquau, Francisco, additional, Gil, Concepcion, additional, Algado, Jose Tomás, additional, Suarez-García, Inés, additional, Malmierca, Eduardo, additional, González-Ruano, Patricia, additional, Ruiz, M. Pilar, additional, Pascual, José Francisco, additional, Sáez, Elena, additional, Balsalobre, Luz, additional, López, M. Villa, additional, Omar, Mohamed, additional, Herrero, Carmen, additional, Gómez, M. Amparo, additional, Alberto de Zarraga, Miguel, additional, Pérez, Desiré, additional, Estrada, Vicente, additional, Sanz, Nieves, additional, Cabello, Noemí, additional, García, Jorge Vergas, additional, Núñez, Maria Jose, additional, Sagastagoitia, Iñigo, additional, Górgolas, Miguel, additional, Cabello, Alfonso, additional, Álvarez, Beatriz, additional, Prieto, Laura, additional, Carrillo, Irene, additional, Sanz, José, additional, Arranz, Alberto, additional, Hernández, Cristina, additional, Novella, María, additional, Galindo, M. José, additional, Ferrer, Ana, additional, Román, Antonio Rivero, additional, Ruíz, Inma, additional, Juárez, Antonio Rivero, additional, López, Pedro, additional, Machuca, Isabel, additional, Frias, Mario, additional, Camacho, Ángela, additional, Pérez, Ignacio, additional, Corona, Diana, additional, Cervero, Miguel, additional, Torres, Rafael, additional, Pineda, Juan Antonio, additional, Rincón, Pilar, additional, Macías, Juan, additional, Real, Luis Miguel, additional, Corma, Anais, additional, Gonzalez-Serna, Alejandro, additional, Pérez, Alexandre, additional, Morano, Luis, additional, Miralles, Celia, additional, Ocampo, Antonio, additional, Pousada, Guillermo, additional, Patiño, Lucía, additional, Dueñas, Carlos, additional, Gutiérrez, Sara, additional, Tapia, Elena, additional, Novoa, Cristina, additional, Egües, Xjoylin, additional, and Telleria, Pablo, additional

Published
2023
Full Text
View/download PDF

9. Lipoprotein Profile in Immunological Non-Responders PLHIV after Antiretroviral Therapy Initiation

Author

Masip, Jenifer, primary, Jorba, Rosa, additional, López-Dupla, Miguel, additional, Domingo, Pere, additional, Pacheco, Yolanda María, additional, García-Pardo, Graciano, additional, Martínez, Esteban, additional, Viladés, Consuelo, additional, Veloso, Sergi, additional, Alba, Verónica, additional, Olona, Montserrat, additional, Vidal, Francesc, additional, Gómez-Bertomeu, Frederic, additional, Peraire, Joaquim, additional, and Rull, Anna, additional

Published
2022
Full Text
View/download PDF

10. Elevated α-Ketoglutaric Acid Concentrations and a Lipid-Balanced Signature Are the Key Factors in Long-Term HIV Control

Author

Masip, Jenifer, Rallón, Norma, Yeregui, Elena, Olona, Montserrat, Resino, Salvador, Benito, José Miguel, Viladés, Consuelo, García-Pardo, Graciano, Alcamí, José, Ruiz-Mateos, Ezequiel, Gómez-Bertomeu, Frederic, Vargas, Montserrat, Navarro, Marta, Oteo, José A, Pineda, Juan A, Martí, Anna, Alba, Verónica, Vidal, Francesc, Peraire, Joaquin, Rull, Anna, ECRIS integrated in the Spanish AIDS Research Network, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Red de Investigación Cooperativa en Investigación en Sida (España), Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas), Rovira i Virgili University (España), Instituto de Salud Carlos III, Consejo Superior de Investigaciones Científicas (España), Unión Europea. Fondo Social Europeo (ESF/FSE), Agency for Administration of University and Research, Gilead Sciences (Spain), European Commission, Generalitat de Catalunya, Gilead Research Scholars, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España), Universidad Rovira i Virgili, Institut d'Investigació Sanitària Pere Virgili, and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica

Subjects
Mass spectrometry, Immunology, HIV Infections, HIV infection, Lipids, Long-term, Lipidomics, HIV-1, Immunology and Allergy, Metabolomics, Humans, Ketoglutaric Acids, Elite controllers (ECs), Viral, Kreb's cycle, Follow-Up Studies
Abstract

Long-term elite controllers (LTECs) are a fascinating small subset of HIV individuals with viral and immunological HIV control in the long term that have been designated as models of an HIV functional cure. However, data on the LTEC phenotype are still scarce, and hence, the metabolomics and lipidomics signatures in the LTEC-extreme phenotype, LTECs with more than 10 years of viral and immunological HIV control, could be pivotal to finding the keys for functional HIV remission. Metabolomics and lipidomics analyses were performed using high-resolution mass spectrometry (ultra-high-performance liquid chromatography-electrospray ionization-quadrupole time of flight [UHPLC-(ESI) qTOF] in plasma samples of 13 patients defined as LTEC-extreme, a group of 20 LTECs that lost viral and/or immunological control during the follow-up study (LTEC-losing) and 9 EC patients with short-term viral and immunological control (less than 5 years; no-LTEC patients). Long-term viral and immunological HIV-1 control was found to be strongly associated with elevated tricarboxylic acid (TCA) cycle function. Interestingly, of the nine metabolites identified in the TCA cycle, α-ketoglutaric acid (p = 0.004), a metabolite implicated in the activation of the mTOR complex, a modulator of HIV latency and regulator of several biological processes, was found to be a key metabolite in the persistent control. On the other hand, a lipidomics panel combining 45 lipid species showed an optimal percentage of separation and an ability to differentiate LTEC-extreme from LTEC-losing, revealing that an elevated lipidomics plasma profile could be a predictive factor for the reignition of viral replication in LTEC individuals., This work was supported by the Fondo de Investigación Sanitaria [PI13/0796, PI16/00503, PI16/0684, PI18/1532, PI19/00004, PI19/01127, PI19/01337 PI16/001769, PI19/00973, and PI20/00326]-ISCIII-FEDER (co-funded by the European Regional Development Fund/European Social Fund; “A way to make Europe”/”Investing in your future”); Programa de Suport als Grups de Recerca AGAUR (2017SGR948); Gilead Fellowship Program GLD14/293; The SPANISH AIDS Research Network [RD16/0002/0001, RD16/0002/0002, RD16/0025/0006, RD16/0025/0013, and RD16/0025/0020]-ISCIII-FEDER (Spain); and the Centro de Investigación Biomédica en Red de Enfermedades Infecciosas-ISCIII [CB21/13/00015, CB21/13/00020, and CB21/13/00044], Madrid, Spain. JM is supported by the Universitat Rovira I Virgili under grant agreement “2019PMF-PIPF-18,” through the call “Martí Franquès Research Fellowship Programme.” NR is a Miguel Servet researcher from the ISCIII [CPII19/00025]. EY is supported by the Instituto de Salud Carlos III (ISCIII) under grant agreement “FI20/0011800” through the program “Contratos Predoctorales de Formación en Investigación en Salud.” ER-M was supported by the Spanish National Research Council (CSIC). FV is supported by grants from the Programa de Intensificación de Investigadores (INT20/00031)-ISCIII and by “Premi a la Trajectòria Investigadora als Hospitals de l’ICS 2018.” AR is supported by IISPV through the project “2019/IISPV/05” (Boosting Young Talent), by GeSIDA through the “III Premio para Jóvenes Investigadores 2019,” and by the Instituto de Salud Carlos III (ISCIII) under grant agreement “CP19/00146” through the Miguel Servet Program.

Published
2022

11. Adipokines as New Biomarkers of Immune Recovery: Apelin Receptor, RBP4 and ZAG Are Related to CD4+ T-Cell Reconstitution in PLHIV on Suppressive Antiretroviral Therapy

Author

Instituto de Salud Carlos III, European Commission, Agència de Gestió d'Ajuts Universitaris i de Recerca, Red Española de Investigación en SIDA, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España), Institut d'Investigació Sanitària Pere Virgili, Yeregui, Elena, Masip, Jenifer, Viladés, Consuelo, Domingo, Pere, Pacheco, Yolanda M., Blanco, Julià, Mallolas, Josep, Alba, Verónica, Vargas, Montserrat, García-Pardo, Graciano, Negredo, Eugenia, Olona, Montserrat, Vidal-González, Judit, Peraire, Maria, Martí, Anna, Reverté, Laia, Gómez-Bertomeu, Frederic, Leal, Manuel, Vidal, Francesc, Peraire, Joaquim, Rull, Anna, Instituto de Salud Carlos III, European Commission, Agència de Gestió d'Ajuts Universitaris i de Recerca, Red Española de Investigación en SIDA, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España), Institut d'Investigació Sanitària Pere Virgili, Yeregui, Elena, Masip, Jenifer, Viladés, Consuelo, Domingo, Pere, Pacheco, Yolanda M., Blanco, Julià, Mallolas, Josep, Alba, Verónica, Vargas, Montserrat, García-Pardo, Graciano, Negredo, Eugenia, Olona, Montserrat, Vidal-González, Judit, Peraire, Maria, Martí, Anna, Reverté, Laia, Gómez-Bertomeu, Frederic, Leal, Manuel, Vidal, Francesc, Peraire, Joaquim, and Rull, Anna

Abstract

A significant proportion of people living with HIV (PLHIV) who successfully achieve virological suppression fail to recover CD4+ T-cell counts. Since adipose tissue has been discovered as a key immune organ, this study aimed to assess the role of adipokines in the HIV immunodiscordant response. This is a multicenter prospective study including 221 PLHIV starting the first antiretroviral therapy (ART) and classified according to baseline CD4+ T-cell counts/µL (controls > 200 cells/µL and cases ≤ 200 cells/µL). Immune failure recovery was considered when cases did not reach more than 250 CD4+ T cells/µL at 144 weeks (immunological nonresponders, INR). Circulating adipokine concentrations were longitudinally measured using enzyme-linked immunosorbent assays. At baseline, apelin receptor (APLNR) and zinc-alpha-2-glycoprotein (ZAG) concentrations were significantly lower in INRs than in immunological responders (p = 0.043 and p = 0.034), and they remained lower during all ART follow-up visits (p = 0.044 and p = 0.028 for APLNR, p = 0.038 and p = 0.010 for ZAG, at 48 and 144 weeks, respectively). ZAG levels positively correlated with retinol-binding protein 4 (RBP4) levels (p < 0.01), and low circulating RBP4 concentrations were related to a low CD4+ T-cell gain (p = 0.018 and p = 0.039 at 48 and 144 weeks, respectively). Multiple regression adjusted for clinical variables and adipokine concentrations confirmed both low APLNR and RBP4 as independent predictors for CD4+ T cells at 144 weeks (p < 0.001). In conclusion, low APLNR and RBP4 concentrations were associated with poor immune recovery in treated PLHIV and could be considered predictive biomarkers of a discordant immunological response.

Published
2022

12. Lipoprotein Profile in Immunological Non-Responders PLHIV after Antiretroviral Therapy Initiation

Author

Universitat Rovira i Virgili, Masip, Jenifer; Jorba, Rosa; Lopez-Dupla, Miguel; Domingo, Pere; Maria Pacheco, Yolanda; Garcia-Pardo, Graciano; Martinez, Esteban; Vilades, Consuelo; Veloso, Sergi; Alba, Veronica; Olona, Montserrat; Vidal, Francesc; Gomez-Bertomeu, Frederic; Peraire, Joaquim; Rull, Anna, Universitat Rovira i Virgili, and Masip, Jenifer; Jorba, Rosa; Lopez-Dupla, Miguel; Domingo, Pere; Maria Pacheco, Yolanda; Garcia-Pardo, Graciano; Martinez, Esteban; Vilades, Consuelo; Veloso, Sergi; Alba, Veronica; Olona, Montserrat; Vidal, Francesc; Gomez-Bertomeu, Frederic; Peraire, Joaquim; Rull, Anna

Abstract

Nuclear magnetic resonance (NMR)-based advanced lipoprotein tests have demonstrated that LDL and HDL particle numbers (LDL-P and HDL-P) are more powerful cardiovascular (CV) risk biomarkers than conventional cholesterol markers. Of interest, in people living with HIV (PLHIV), predictors of preclinical atherosclerosis and vascular dysfunction may be associated with impaired immune function. We previously stated that immunological non-responders (INR) were at higher CV risk than immunological responders (IR) before starting antiretroviral therapy (ART). Using Liposcale (R) tests, we characterized the lipoprotein profile from the same cohort of PLHIV at month 12 and month 36 after starting ART, intending to explore what happened with these indicators of CV risk during viral suppression. ART initiation dissipates the differences in lipoprotein-based CV risk markers between INR and IR, and only an increase in the number of HDL-P was found in INR + IR when compared to controls (p = 0.047). Interestingly, CD4(+) T-cell counts negatively correlated with medium HDL-P concentrations at month 12 in all individuals (p = -0.335, p = 0.003). Longitudinal analyses showed an important increase in LDL-P and HDL-P at month 36 when compared to baseline values in both IR and INR. A proper balance between a proatherogenic and atherogenic environment may be related to the reconstitution of CD4(+) T-cell count in PLHIV.

Published
2022

13. Elevated α-Ketoglutaric Acid Concentrations and a Lipid-Balanced Signature Are the Key Factors in Long-Term HIV Control

Author

Masip, Jenifer, primary, Rallón, Norma, additional, Yeregui, Elena, additional, Olona, Montserrat, additional, Resino, Salvador, additional, Benito, José M., additional, Viladés, Consuelo, additional, García-Pardo, Graciano, additional, Alcamí, José, additional, Ruiz-Mateos, Ezequiel, additional, Gómez-Bertomeu, Frederic, additional, Vargas, Montserrat, additional, Navarro, Marta, additional, Oteo, José A., additional, Pineda, Juan A., additional, Martí, Anna, additional, Alba, Verónica, additional, Vidal, Francesc, additional, Peraire, Joaquin, additional, and Rull, Anna, additional

Published
2022
Full Text
View/download PDF

14. Adipokines as New Biomarkers of Immune Recovery: Apelin Receptor, RBP4 and ZAG Are Related to CD4

Author

Elena, Yeregui, Jenifer, Masip, Consuelo, Viladés, Pere, Domingo, Yolanda M, Pacheco, Julià, Blanco, Josep, Mallolas, Verónica, Alba, Montserrat, Vargas, Graciano, García-Pardo, Eugènia, Negredo, Montserrat, Olona, Judit, Vidal-González, Maria, Peraire, Anna, Martí, Laia, Reverté, Fréderic, Gómez-Bertomeu, Manuel, Leal, Francesc, Vidal, Joaquim, Peraire, and Anna, Rull

Subjects
Adult, CD4-Positive T-Lymphocytes, Male, Apelin Receptors, HIV Infections, Middle Aged, Viral Load, CD4 Lymphocyte Count, Adipokines, Antiretroviral Therapy, Highly Active, HIV-1, Humans, Female, Prospective Studies, Retinol-Binding Proteins, Plasma, Biomarkers
Abstract

A significant proportion of people living with HIV (PLHIV) who successfully achieve virological suppression fail to recover CD4

Published
2022

15. Adipokines as New Biomarkers of Immune Recovery: Apelin Receptor, RBP4 and ZAG Are Related to CD4+ T-Cell Reconstitution in PLHIV on Suppressive Antiretroviral Therapy

Author

Yeregui, Elena, primary, Masip, Jenifer, additional, Viladés, Consuelo, additional, Domingo, Pere, additional, Pacheco, Yolanda M., additional, Blanco, Julià, additional, Mallolas, Josep, additional, Alba, Verónica, additional, Vargas, Montserrat, additional, García-Pardo, Graciano, additional, Negredo, Eugènia, additional, Olona, Montserrat, additional, Vidal-González, Judit, additional, Peraire, Maria, additional, Martí, Anna, additional, Reverté, Laia, additional, Gómez-Bertomeu, Fréderic, additional, Leal, Manuel, additional, Vidal, Francesc, additional, Peraire, Joaquim, additional, and Rull, Anna, additional

Published
2022
Full Text
View/download PDF

16. Lipoprotein Profile in Immunological Non-Responders PLHIV after Antiretroviral Therapy Initiation

Author

Jenifer Masip, Rosa Jorba, Miguel López-Dupla, Pere Domingo, Yolanda María Pacheco, Graciano García-Pardo, Esteban Martínez, Consuelo Viladés, Sergi Veloso, Verónica Alba, Montserrat Olona, Francesc Vidal, Frederic Gómez-Bertomeu, Joaquim Peraire, Anna Rull, Instituto de Salud Carlos III, European Commission, Generalitat de Catalunya, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España), Universidad Rovira i Virgili, Fundación SEIMC-GESIDA, Jorba, Rosa, López-Dupla, Miguel, Domingo, Pere, and Rull, Anna

Subjects
cardiovascular risk, Anti-HIV Agents, antiretroviral therapy, immunological non-responder, lipoproteins, longitudinal analysis, nuclear magnetic resonance, people living with HIV, Lipoproteins, HIV Infections, Catalysis, Nuclear magnetic resonance, Inorganic Chemistry, Humans, Physical and Theoretical Chemistry, Molecular Biology, Spectroscopy, Organic Chemistry, Longitudinal analysis, Immunological non-responder, General Medicine, Atherosclerosis, Cardiovascular risk, Antiretroviral therapy, Computer Science Applications, People living with HIV, Cholesterol, Biomarkers
Abstract

Nuclear magnetic resonance (NMR)-based advanced lipoprotein tests have demonstrated that LDL and HDL particle numbers (LDL-P and HDL-P) are more powerful cardiovascular (CV) risk biomarkers than conventional cholesterol markers. Of interest, in people living with HIV (PLHIV), predictors of preclinical atherosclerosis and vascular dysfunction may be associated with impaired immune function. We previously stated that immunological non-responders (INR) were at higher CV risk than immunological responders (IR) before starting antiretroviral therapy (ART). Using Liposcale® tests, we characterized the lipoprotein profile from the same cohort of PLHIV at month 12 and month 36 after starting ART, intending to explore what happened with these indicators of CV risk during viral suppression. ART initiation dissipates the differences in lipoprotein-based CV risk markers between INR and IR, and only an increase in the number of HDL-P was found in INR + IR when compared to controls (p = 0.047). Interestingly, CD4+ T-cell counts negatively correlated with medium HDL-P concentrations at month 12 in all individuals (ρ = -0.335, p = 0.003). Longitudinal analyses showed an important increase in LDL-P and HDL-P at month 36 when compared to baseline values in both IR and INR. A proper balance between a proatherogenic and atherogenic environment may be related to the reconstitution of CD4+ T-cell count in PLHIV., This research was funded by the Fondo de Investigacion Sanitaria [PI16/00503, PI19/01337 and PI20/00326]-ISCIII-FEDER (co-funded by the European Regional Development Fund/European Social Fund; “A way to make Europe”/”Investing in your future”); Programa de Suport als Grups de Recerca AGAUR (2017SGR948), the SPANISH AIDS Research Network [RD16/0025/0006]-ISCIII-FEDER (Spain) and the Centro de Investigación Biomédica en Red de Enfermedades Infecciosas-ISCIII (CIBERINFEC) [CB21/13/00020], Madrid, Spain. JM is supported by the Universitat Rovira I Virgili under grant agreement “2019PMF-PIPF-18”, through the call “Martí Franquès Research Fellowship Programme”. FV is supported by grants from the Programa de Intensificación de Investigadores (INT20/00031)-ISCIII and by “Premi a la Trajectòria Investigadora dels Hospitals de l’ICS 2018”. AR is supported by a grant from IISPV through the project “2019/IISPV/05” (Boosting Young Talent), by GeSIDA through the “III Premio para Jóvenes Investigadores 2019” and by the Instituto de Salud Carlos III (ISCIII) under grant agreement “CP19/00146” through the Miguel Servet Program.

Published
2022
Full Text
View/download PDF

17. Evolution of Serum Acute-Phase Glycoproteins Assessed by 1H-NMR in HIV Elite Controllers

Author

Malo, Ana-Irene, primary, Peraire, Joaquim, additional, Ruiz-Mateos, Ezequiel, additional, Masip, Jenifer, additional, Amigó, Núria, additional, Alcamí, José, additional, Moreno, Santiago, additional, Girona, Josefa, additional, García-Pardo, Graciano, additional, Reig, Rosaura, additional, Vidal, Francesc, additional, Castro, Antoni, additional, Masana, Lluís, additional, and Rull, Anna, additional

Published
2021
Full Text
View/download PDF

18. High circulating SDF-1and MCP-1 levels and genetic variations in CXCL12, CCL2 and CCR5: Prognostic signature of immune recovery status in treated HIV-positive patients

Author

Laia Reverté, Francesc Vidal, Andra Ceausu, Josep Mallolas, Carles Perpiñán, Alexy Inciarte, Jenifer Masip, Sergi Veloso, Verónica Alba, Pere Domingo, Judit Vidal-Gonzalez, Joaquim Peraire, Yolanda M. Pacheco, Anna Rull, Elena Yeregui, Montserrat Vargas, Anna Martí, Vicenç Falcó, Consuelo Viladés, Maria Peraire, Instituto de Salud Carlos III, European Commission, Generalitat de Catalunya, and Junta de Andalucía

Subjects
0301 basic medicine, Male, CCR2, Chemokine, animal diseases, Polymorphisms variants, lcsh:Medicine, HIV Infections, medicine.disease_cause, 0302 clinical medicine, Risk Factors, Antiretroviral Therapy, Highly Active, CX3CR1, Chemokine CCL2, lcsh:R5-920, biology, hemic and immune systems, General Medicine, Middle Aged, Prognosis, 030220 oncology & carcinogenesis, Chemokine secretion, Female, Chemokines, lcsh:Medicine (General), Poor immune recovery, Research Paper, Adult, Genotype, Receptors, CCR5, Genetic polymorphisms, General Biochemistry, Genetics and Molecular Biology, CCL5, Immunomodulation, 03 medical and health sciences, Immune system, parasitic diseases, medicine, VIH (Virus), Immunodeficiency, Humans, CX3CL1, Alleles, Genetic Association Studies, Immunodeficiència, business.industry, HIV (Viruses), Polimorfisme genètic, Chemokine receptors, lcsh:R, Immunity, Genetic Variation, HIV, Immune dysregulation, Chemokine CXCL12, CD4 Lymphocyte Count, 030104 developmental biology, Case-Control Studies, Immunology, biology.protein, business
Abstract

© 2020 The Authors., [Background]: The underlying mechanisms of incomplete immune reconstitution in treated HIV-positive patients are very complex and may be multifactorial, but perturbation of chemokine secretion could play a key role in CD4+ T-cell turnover., [Methods]: We evaluated the circulating baseline and 48-week follow-up concentrations of SDF-1/CXCL12, fractalkine/CX3CL1, MCP-1/CCL2, MIP-α/CCL3, MIP-β/CCL4 and RANTES/CCL5, and we estimated their association with CXCL12, CX3CR1, CCR2, CCL5 and CCR5 single nucleotide polymorphisms (SNPs) to investigate multiple chemokine-chemokine receptor signatures associated with immune dysregulation preceding poor immune recovery., [Findings]: The circulating concentrations and gene expression patterns of SDF-1/CXCL12 (CXCL12 rs1801157) and MCP-1/CCL2 (CCR2 rs1799864_814) were associated with immune recovery status. CCR2 rs1799864_814 and CCR5 rs333_814 (Δ32) determine the baseline plasma RANTES and MIP-α concentrations, respectively, in participants with poor immune response., [Interpretation]: SDF-1/CXCL12 and MCP-1/CCL2 could be considered prognostic markers of immune failure despite suppressive antiretroviral therapy. The strong linkage disequilibrium (LD) between CCR2 rs1799864_814 and CCR5 rs1800024 indicated that the alleles of each gene are inherited together more often than would be expected by chance., This work was supported by the Fondo de Investigacion Sanitaria [PI10/02635, PI13/0796, PI14/ 0063, PI14/0700, PI16/00503, PI17/0420, PI17/0498, PI18/01216, PI19/01337 and PI20/00326]-ISCIII-FEDER (co-funded by the European Regional Development Fund/European Social Fund; “A way to make Europe”/”Investing in your future”); Programa de Suport als Grups de Recerca AGAUR (2014SGR250, 2017SGR948); Gilead Fellowship Program GLD14/293and GLD19/00,008; and The SPANISH AIDS Research Network [RD12/0017/0005, RD16/0025/0002, RD16/0025/0006, RD16/0025/0019]-ISCIII-FEDER (Spain). FV is supported by grants from the Programa de Intensificación de Investigadores (INT20/00031)-ISCIII. PD is supported by grants from the Programa de Intensificación de Investigadores (INT19/00036)-ISCIII. YMP is supported by the Servicio Andaluz de Salud through Programa Nicolás Monardes (C-0013/17). JVG is supported by the Instituto de Salud Carlos III (ISCIII) under grant agreement “FI19/00330″ through the program “Contratos Predoctorales de Formación en Investigación en Salud”. EY is supported by the Instituto de Salud Carlos III (ISCIII) under grant agreement “FI20/00118″ through the program “Contratos Predoctorales de Formación en Investigación en Salud”. LR is supported by the Instituto de Salud Carlos III (ISCIII) under grant agreement “CD20/00105″ through the program “Sara Borrell”. AR is supported by a grant from the Acció Instrumental d'incorporació de científics i tecnòòlegs (PERIS SLT002/16/00,101), Departament de Salut, Generalitat de Catalunya, by IISPV through the project “2019/IISPV/05″ (Boosting Young Talent), by GeSIDA through the "III Premio para Jóvenes Investigadores 2019″ and by the Instituto de Salud Carlos III (ISCIII) under grant agreement “CP19/00,146″ through the Miguel Servet Program.

Published
2020

19. Evolution of Serum Acute-Phase Glycoproteins Assessed by 1H-NMR in HIV Elite Controllers

Author

Instituto de Salud Carlos III, European Commission, Agència de Gestió d'Ajuts Universitaris i de Recerca, Red Española de Investigación en SIDA, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España), Universidad Rovira i Virgili, Malo, Ana-Irene, Peraire, Joaquim, Ruiz-Mateos, Ezequiel, Masip, Jenifer, Amigó, Núria, Alcamí, José, Moreno, Santiago, Girona, Josefa, García-Pardo, Graciano, Reig, Rosauro, Vidal, Francesc, Castro Dorado, Antonio, Masana, Lluis, Rull, Anna, Instituto de Salud Carlos III, European Commission, Agència de Gestió d'Ajuts Universitaris i de Recerca, Red Española de Investigación en SIDA, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España), Universidad Rovira i Virgili, Malo, Ana-Irene, Peraire, Joaquim, Ruiz-Mateos, Ezequiel, Masip, Jenifer, Amigó, Núria, Alcamí, José, Moreno, Santiago, Girona, Josefa, García-Pardo, Graciano, Reig, Rosauro, Vidal, Francesc, Castro Dorado, Antonio, Masana, Lluis, and Rull, Anna

Abstract

Elite controllers (ECs) are an exceptional group of people living with HIV (PLWH) who maintain undetectable viral loads (VLs) despite not being on antiretroviral therapy (ART). However, this phenotype is heterogeneous, with some of these subjects losing virological control over time. In this longitudinal retrospective study, serum acute-phase glycoprotein profile assessed by proton nuclear magnetic resonance (1H-NMR) was determined in 11 transient controllers (TCs) who spontaneously lost virological control and 11 persistent controllers (PCs) who persistently maintained virological control over time. Both PCs and TCs showed similar acute-phase glycoprotein profiles, even when TCs lost the virological control (GlycB, p = 0.824 and GlycA, p = 0.710), and the serum acute-phase glycoprotein signature in PCs did not differ from that in HIV-negative subjects (GlycB, p = 0.151 and GlycA, p = 0.243). Differences in serum glycoproteins A and B were significant only in ECs compared to HIV-typical progressors (TPs) with < 100 CD4+ T-cells (p < 0.001). 1H-NMR acute-phase glycoprotein profile does not distinguish TCs form PCs before the loss of viral control. ECs maintain a low-grade inflammatory state compared to TPs. PCs revealed a closer serum signature to HIV-negative subjects, reaffirming this phenotype as a closer model of functional control of HIV.

Published
2021

20. High Circulating SDF-1 and MCP-1 Levels and Genetic Variations in CXCL12, CCL2 and CCR5: Prognostic Signature of Immune Recovery Status in Treated HIV-Infected Patients

Author

Elena Yeregui, Consuelo Viladés, Pere Domingo, Andra Ceausu, Yolanda María Pacheco, Sergi Veloso, Alexy Inciarte, Judit Vidal-González, Maria Peraire, Carles Perpiñán, Vicenç Falcó, Jenifer Masip, Veronica Alba, Montserrat Vargas, Anna Martí, Laia Reverté, Francesc Vidal Marsal, Joaquim Peraire, and Anna Rull

Published
2020
Full Text
View/download PDF

21. High Circulating SDF-1 and MCP-1 Levels and Genetic Variations in CXCL12, CCL2 and CCR5: Prognostic Signature of Immune Recovery Status in Treated HIV-Infected Patients

Author

Yeregui, Elena, primary, Viladés, Consuelo, additional, Domingo, Pere, additional, Ceausu, Andra, additional, Pacheco, Yolanda María, additional, Veloso, Sergi, additional, Inciarte, Alexy, additional, Vidal-González, Judit, additional, Peraire, Maria, additional, Perpiñán, Carles, additional, Falcó, Vicenç, additional, Masip, Jenifer, additional, Alba, Veronica, additional, Vargas, Montserrat, additional, Martí, Anna, additional, Reverté, Laia, additional, Vidal Marsal, Francesc, additional, Peraire, Joaquim, additional, and Rull, Anna, additional

Published
2020
Full Text
View/download PDF

22. Evolution of Serum Acute-Phase Glycoproteins Assessed by 1H-NMR in HIV Elite Controllers.

Author

Malo, Ana-Irene, Peraire, Joaquim, Ruiz-Mateos, Ezequiel, Masip, Jenifer, Amigó, Núria, Alcamí, José, Moreno, Santiago, Girona, Josefa, García-Pardo, Graciano, Reig, Rosaura, Vidal, Francesc, Castro, Antoni, Masana, Lluís, and Rull, Anna

Subjects
PROTON magnetic resonance, GLYCOPROTEINS, NUCLEAR magnetic resonance, HIV-positive persons, HIV
Abstract

Elite controllers (ECs) are an exceptional group of people living with HIV (PLWH) who maintain undetectable viral loads (VLs) despite not being on antiretroviral therapy (ART). However, this phenotype is heterogeneous, with some of these subjects losing virological control over time. In this longitudinal retrospective study, serum acute-phase glycoprotein profile assessed by proton nuclear magnetic resonance (1H-NMR) was determined in 11 transient controllers (TCs) who spontaneously lost virological control and 11 persistent controllers (PCs) who persistently maintained virological control over time. Both PCs and TCs showed similar acute-phase glycoprotein profiles, even when TCs lost the virological control (GlycB, p = 0.824 and GlycA, p = 0.710), and the serum acute-phase glycoprotein signature in PCs did not differ from that in HIV-negative subjects (GlycB, p = 0.151 and GlycA, p = 0.243). Differences in serum glycoproteins A and B were significant only in ECs compared to HIV-typical progressors (TPs) with < 100 CD4+ T-cells (p < 0.001). 1H-NMR acute-phase glycoprotein profile does not distinguish TCs form PCs before the loss of viral control. ECs maintain a low-grade inflammatory state compared to TPs. PCs revealed a closer serum signature to HIV-negative subjects, reaffirming this phenotype as a closer model of functional control of HIV. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

23. Differential miRNA plasma profiles associated with the spontaneous loss of HIV‐1 control: miR‐199a‐3p and its potential role as a biomarker for quick screening of elite controllers.

Author

Masip, Jenifer, Gasca‐Capote, Carmen, Jimenez‐Leon, María Reyes, Peraire, Joaquim, Perez‐Gomez, Alberto, Alba, Verónica, Malo, Ana‐Irene, Leal, Lorna, Martín, Carmen Rodríguez, Rallón, Norma, Viladés, Consuelo, Olona, Montserrat, Vidal, Francesc, Ruiz‐Mateos, Ezequiel, and Rull, Anna

Subjects
BIOMARKERS, HIV infections, MICRORNA, HIGH density lipoproteins, METABOLOMICS, LONG-term non-progressors
Abstract

Differential miRNA plasma profiles associated with the spontaneous loss of HIV-1 control: miR-199a-3p and its potential role as a biomarker for quick screening of elite controllers People living with HIV (PLWH) who are able to maintain suppressed viral load (VL) for years in the absence of antiretroviral therapy (ART) are known as elite controllers (ECs). From the 23 miRNAs, 22 miRNAs were positively correlated with viral load (VL), seven miRNAs were positively correlated with CD4 SP + sp T-cell counts, and 11 miRNAs were positively correlated with CD8 SP + sp T-cell counts (Table S3). Then, we also evaluated the plasma miRNA profile in TCs under the postloss condition and we found 38 miRNAs differentially expressed among groups, suggesting that viremia strongly influences the plasma miRNA profile of ECs (Figure 2A, Table S4). [Extracted from the article]

Published
2021
Full Text
View/download PDF

24. Adipokines as New Biomarkers of Immune Recovery: Apelin Receptor, RBP4 and ZAG Are Related to CD4 + T-Cell Reconstitution in PLHIV on Suppressive Antiretroviral Therapy.

Author

Yeregui, Elena, Masip, Jenifer, Viladés, Consuelo, Domingo, Pere, Pacheco, Yolanda M., Blanco, Julià, Mallolas, Josep, Alba, Verónica, Vargas, Montserrat, García-Pardo, Graciano, Negredo, Eugènia, Olona, Montserrat, Vidal-González, Judit, Peraire, Maria, Martí, Anna, Reverté, Laia, Gómez-Bertomeu, Fréderic, Leal, Manuel, Vidal, Francesc, and Peraire, Joaquim

Subjects
ADIPOKINES, ANTIRETROVIRAL agents, APELIN, RETINOL-binding proteins, ENZYME-linked immunosorbent assay, CD4 antigen
Abstract

A significant proportion of people living with HIV (PLHIV) who successfully achieve virological suppression fail to recover CD4+ T-cell counts. Since adipose tissue has been discovered as a key immune organ, this study aimed to assess the role of adipokines in the HIV immunodiscordant response. This is a multicenter prospective study including 221 PLHIV starting the first antiretroviral therapy (ART) and classified according to baseline CD4+ T-cell counts/µL (controls > 200 cells/µL and cases ≤ 200 cells/µL). Immune failure recovery was considered when cases did not reach more than 250 CD4+ T cells/µL at 144 weeks (immunological nonresponders, INR). Circulating adipokine concentrations were longitudinally measured using enzyme-linked immunosorbent assays. At baseline, apelin receptor (APLNR) and zinc-alpha-2-glycoprotein (ZAG) concentrations were significantly lower in INRs than in immunological responders (p = 0.043 and p = 0.034), and they remained lower during all ART follow-up visits (p = 0.044 and p = 0.028 for APLNR, p = 0.038 and p = 0.010 for ZAG, at 48 and 144 weeks, respectively). ZAG levels positively correlated with retinol-binding protein 4 (RBP4) levels (p < 0.01), and low circulating RBP4 concentrations were related to a low CD4+ T-cell gain (p = 0.018 and p = 0.039 at 48 and 144 weeks, respectively). Multiple regression adjusted for clinical variables and adipokine concentrations confirmed both low APLNR and RBP4 as independent predictors for CD4+ T cells at 144 weeks (p < 0.001). In conclusion, low APLNR and RBP4 concentrations were associated with poor immune recovery in treated PLHIV and could be considered predictive biomarkers of a discordant immunological response. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results