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1. Real-World Impact of Upfront Cytoreductive Nephrectomy in Metastatic Non-Clear Cell Renal Cell Carcinoma Treated with First-Line Immunotherapy Combinations or Tyrosine Kinase Inhibitors (A Sub-Analysis from the ARON-1 Retrospective Study)

Author

Fiala, Ondřej, Buti, Sebastiano, Bamias, Aristotelis, Massari, Francesco, Pichler, Renate, Maruzzo, Marco, Grande, Enrique, De Giorgi, Ugo, Molina-Cerrillo, Javier, Seront, Emmanuel, Calabrò, Fabio, Myint, Zin W., Facchini, Gaetano, Kopp, Ray Manneh, Berardi, Rossana, Kucharz, Jakub, Vitale, Maria Giuseppa, Pinto, Alvaro, Formisano, Luigi, Büttner, Thomas, Messina, Carlo, Monteiro, Fernando Sabino M., Battelli, Nicola, Kanesvaran, Ravindran, Büchler, Tomáš, Kopecký, Jindřich, Santini, Daniele, Giudice, Giulia Claire, Porta, Camillo, and Santoni, Matteo

Published
2024
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2. Pembrolizumab in patients with advanced upper tract urothelial carcinoma: a real-world study from ARON-2 project

Author

Rizzo, Alessandro, Buti, Sebastiano, Giannatempo, Patrizia, Salah, Samer, Molina-Cerrillo, Javier, Massari, Francesco, Kopp, Ray Manneh, Fiala, Ondřej, Galli, Luca, Myint, Zin W., Tural, Deniz, Soares, Andrey, Pichler, Renate, Mennitto, Alessia, Abahssain, Halima, Calabrò, Fabio, Monteiro, Fernando Sabino M., Albano, Anna, Mollica, Veronica, Giudice, Giulia Claire, Takeshita, Hideki, and Santoni, Matteo

Published
2024
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3. External validation of a red cell-based blood prognostic score in patients with metastatic renal cell carcinoma treated with first-line immunotherapy combinations

Author

Maffezzoli, Michele, Santoni, Matteo, Mazzaschi, Giulia, Rodella, Sara, Lai, Eleonora, Maruzzo, Marco, Basso, Umberto, Bimbatti, Davide, Iacovelli, Roberto, Anghelone, Annunziato, Fiala, Ondřej, Rebuzzi, Sara Elena, Fornarini, Giuseppe, Lolli, Cristian, Massari, Francesco, Rosellini, Matteo, Mollica, Veronica, Nasso, Cecilia, Acunzo, Alessandro, Silini, Enrico Maria, Quaini, Federico, De Filippo, Massimo, Brunelli, Matteo, Banna, Giuseppe L., Rescigno, Pasquale, Signori, Alessio, and Buti, Sebastiano

Published
2024
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5. Global real-world experiences with pembrolizumab in advanced urothelial carcinoma after platinum-based chemotherapy: the ARON-2 study

Author

Massari, Francesco, Santoni, Matteo, Takeshita, Hideki, Okada, Yohei, Tapia, Jose Carlos, Basso, Umberto, Maruzzo, Marco, Scagliarini, Sarah, Büttner, Thomas, Fornarini, Giuseppe, Myint, Zin W., Galli, Luca, Souza, Vinicius Carrera, Pichler, Renate, De Giorgi, Ugo, Gandur, Nathalia, Lam, Elaine T., Gilbert, Danielle, Popovic, Lazar, Grande, Enrique, Mammone, Giulia, Berardi, Rossana, Crabb, Simon J., Kemp, Robert, Molina-Cerrillo, Javier, Freitas, Marcelo, Luz, Murilo, Iacovelli, Roberto, Calabrò, Fabio, Tural, Deniz, Atzori, Francesco, Küronya, Zsófia, Chiari, Rita, Campos, Saul, Caffo, Orazio, Fay, André P., Kucharz, Jakub, Zucali, Paolo Andrea, Rinck, José Augusto, Zeppellini, Annalisa, Bastos, Diogo Assed, Aurilio, Gaetano, Mota, Augusto, Trindade, Karine, Ortega, Cinzia, Sade, Juan Pablo, Rizzo, Mimma, Fiala, Ondřej, Vau, Nuno, Giannatempo, Patrizia, Barillas, Allan, Monteiro, Fernando Sabino M., Dauster, Breno, Mennitto, Alessia, Nogueira, Lucas, de Carvalho Fernandes, Roni, Seront, Emmanuel, Aceituno, Luís Garcia, Grillone, Francesco, Cutuli, Hernan Javier, Fernandez, Mauricio, Bassanelli, Maria, Kopp, Ray Manneh, Roviello, Giandomenico, Abahssain, Halima, Procopio, Giuseppe, Milella, Michele, Kopecky, Jindrich, Martignetti, Angelo, Messina, Carlo, Caitano, Manuel, Inman, Eva, Kanesvaran, Ravindran, Herchhorn, Daniel, Santini, Daniele, Bamias, Aristotelis, Bisonni, Renato, Mosca, Alessandra, Morelli, Franco, Maluf, Fernando, Soares, Andrey, Nunes, Fernando, Pinto, Alvaro, Zgura, Anca, Incorvaia, Lorena, Ansari, Jawaher, Zabalza, Ignacio Ortego, Landmesser, Johannes, Rizzo, Alessandro, Mollica, Veronica, Marchetti, Andrea, Rosellini, Matteo, Sorgentoni, Giulia, Battelli, Nicola, Buti, Sebastiano, Porta, Camillo, and Bellmunt, Joaquim

Published
2024
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7. Sex and survival outcomes in patients with renal cell carcinoma receiving first-line immune-based combinations

Author

Incorvaia, Lorena, Monteiro, Fernando Sabino Marques, Massari, Francesco, Park, Se Hoon, Roviello, Giandomenico, Fiala, Ondřej, Myint, Zin W., Kucharz, Jakub, Molina-Cerrillo, Javier, Santini, Daniele, Buttner, Thomas, Poprach, Alexandr, Kopecky, Jindrich, Zeppellini, Annalisa, Pichler, Martin, Buchler, Tomas, Pichler, Renate, Facchini, Gaetano, Fay, Andre Poisl, Soares, Andrey, Manneh, Ray, Iezzi, Laura, Kuronya, Zsofia, Russo, Antonio, Bourlon, Maria T., Bhuva, Dipen, Ansari, Jawaher, Kanesvaran, Ravindran, Grande, Enrique, Buti, Sebastiano, and Santoni, Matteo

Published
2024
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9. Bone targeting agents, but not radiation therapy, improves survival in patients with bone metastases from advanced urothelial carcinoma receiving pembrolizumab: results from the ARON-2 study

Author

Santoni, Matteo, Massari, Francesco, Takeshita, Hideki, Tapia, Jose Carlos, Dionese, Michele, Pichler, Renate, Rizzo, Mimma, Lam, Elaine T., Grande, Enrique, Kemp, Robert, Molina-Cerrillo, Javier, Calabrò, Fabio, Tural, Deniz, Küronya, Zsófia, Kucharz, Jakub, Fiala, Ondrej, Seront, Emmanuel, Kopp, Ray Manneh, Abahssain, Halima, Kopecky, Jindrich, Martignetti, Angelo, Kanesvaran, Ravindran, Zakopoulou, Roubini, Ansari, Jawaher, Landmesser, Johannes, Mollica, Veronica, Porta, Camillo, Bellmunt, Joaquim, Salah, Samer, and Santini, Daniele

Published
2023
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11. Evaluation of an institutional series of low-grade oncocytic tumor (LOT) of the kidney and review of the mutational landscape of LOT

Author

Ricci, Costantino, Ambrosi, Francesca, Franceschini, Tania, Giunchi, Francesca, Grillini, Alessia, Franchini, Eugenia, Grillini, Marco, Schiavina, Riccardo, Massari, Francesco, Mollica, Veronica, Tateo, Valentina, Bianchi, Federico Mineo, Bianchi, Lorenzo, Droghetti, Matteo, Maloberti, Thais, Tallini, Giovanni, Colecchia, Maurizio, Acosta, Andres Martin, Lobo, João, Trpkov, Kiril, Fiorentino, Michelangelo, and de Biase, Dario

Published
2023
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12. Use of concomitant proton pump inhibitors, statins or metformin in patients treated with pembrolizumab for metastatic urothelial carcinoma: data from the ARON-2 retrospective study

Author

Fiala, Ondřej, Buti, Sebastiano, Takeshita, Hideki, Okada, Yohei, Massari, Francesco, Palacios, Georgia Anguera, Dionese, Michele, Scagliarini, Sarah, Büttner, Thomas, Fornarini, Giuseppe, Myint, Zin W., Galli, Luca, Souza, Vinicius Carrera, Pichler, Renate, De Giorgi, Ugo, Quiroga, María Natalia Gandur, Gilbert, Danielle, Popovic, Lazar, Grande, Enrique, Mammone, Giulia, Berardi, Rossana, Crabb, Simon J., Molina-Cerrillo, Javier, Freitas, Marcelo, Luz, Murilo, Iacovelli, Roberto, Calabrò, Fabio, Tural, Deniz, Atzori, Francesco, Küronya, Zsófia, Chiari, Rita, Campos, Saul, Caffo, Orazio, Fay, André P., Kucharz, Jakub, Zucali, Paolo Andrea, Rinck, José Augusto, Zeppellini, Annalisa, Bastos, Diogo Assed, Aurilio, Gaetano, Mota, Augusto, Trindade, Karine, Ortega, Cinzia, Sade, Juan Pablo, Rizzo, Mimma, Vau, Nuno, Giannatempo, Patrizia, Barillas, Allan, Monteiro, Fernando Sabino Marques, Dauster, Breno, Cattrini, Carlo, Nogueira, Lucas, de Carvalho Fernandes, Roni, Seront, Emmanuel, Aceituno, Luís Garcia, Grillone, Francesco, Cutuli, Hernan Javier, Fernandez, Mauricio, Bassanelli, Maria, Roviello, Giandomenico, Abahssain, Halima, Procopio, Giuseppe, Milella, Michele, Kopecky, Jindrich, Martignetti, Angelo, Messina, Carlo, Caitano, Manuel, Inman, Eva, Kanesvaran, Ravindran, Herchenhorn, Daniel, Santini, Daniele, Manneh, Ray, Bisonni, Renato, Zakopoulou, Roubini, Mosca, Alessandra, Morelli, Franco, Maluf, Fernando, Soares, Andrey, Nunes, Fernando, Pinto, Alvaro, Zgura, Anca, Incorvaia, Lorena, Ansari, Jawaher, Zabalza, Ignacio Ortego, Landmesser, Johannes, Rizzo, Alessandro, Mollica, Veronica, Sorgentoni, Giulia, Battelli, Nicola, Porta, Camillo, Bellmunt, Joaquim, and Santoni, Matteo

Published
2023
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13. Real-world effectiveness of pembrolizumab as first-line therapy for cisplatin-ineligible patients with advanced urothelial carcinoma: the ARON-2 study

Author

Santoni, Matteo, Myint, Zin W., Büttner, Thomas, Takeshita, Hideki, Okada, Yohei, Lam, Elaine T., Gilbert, Danielle, Küronya, Zsófia, Tural, Deniz, Pichler, Renate, Grande, Enrique, Crabb, Simon J., Kemp, Robert, Massari, Francesco, Scagliarini, Sarah, Iacovelli, Roberto, Vau, Nuno, Basso, Umberto, Maruzzo, Marco, Molina-Cerrillo, Javier, Galli, Luca, Bamias, Aristotelis, De Giorgi, Ugo, Zucali, Paolo Andrea, Rizzo, Mimma, Seront, Emmanuel, Popovic, Lazar, Caffo, Orazio, Buti, Sebastiano, Kanesvaran, Ravindran, Kopecky, Jindrich, Kucharz, Jakub, Zeppellini, Annalisa, Fiala, Ondřej, Landmesser, Johannes, Ansari, Jawaher, Giannatempo, Patrizia, Rizzo, Alessandro, Zabalza, Ignacio Ortego, Monteiro, Fernando Sabino M., Battelli, Nicola, Calabrò, Fabio, and Porta, Camillo

Published
2023
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14. Clinical Outcomes and Prognostic Factors in Patients With Penile Carcinoma: A Sub-Analysis From Meet-URO 23 (I-RARE) Registry Study

Author

Mollica, Veronica, Massari, Francesco, Maruzzo, Marco, Bimbatti, Davide, Claps, Melanie, Maiorano, Brigida Anna, Vitale, Maria Giuseppa, Iacovelli, Roberto, Ermacora, Paola, Roviello, Giandomenico, Calabrò, Fabio, Caffo, Orazio, Vignani, Francesca, Grillone, Francesco, Pierantoni, Francesco, Di Napoli, Marilena, Mennitto, Alessia, Marchetti, Andrea, Mattana, Alvise, Cavo, Alessia, Bassanelli, Maria, Formisano, Luigi, Prati, Veronica, Giudice, Giulia Claire, and Buti, Sebastiano

Published
2024
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15. Global Real-World Outcomes of Patients Receiving Immuno-Oncology Combinations for Advanced Renal Cell Carcinoma: The ARON-1 Study

Author

Santoni, Matteo, Massari, Francesco, Myint, Zin W., Iacovelli, Roberto, Pichler, Martin, Basso, Umberto, Kopecky, Jindrich, Kucharz, Jakub, Buti, Sebastiano, Rizzo, Mimma, Galli, Luca, Büttner, Thomas, De Giorgi, Ugo, Kanesvaran, Ravindran, Fiala, Ondřej, Grande, Enrique, Zucali, Paolo Andrea, Fornarini, Giuseppe, Bourlon, Maria T., Scagliarini, Sarah, Molina-Cerrillo, Javier, Aurilio, Gaetano, Matrana, Marc R., Pichler, Renate, Cattrini, Carlo, Büchler, Tomas, Seront, Emmanuel, Calabrò, Fabio, Pinto, Alvaro, Berardi, Rossana, Zgura, Anca, Mammone, Giulia, Ansari, Jawaher, Atzori, Francesco, Chiari, Rita, Bamias, Aristotelis, Caffo, Orazio, Procopio, Giuseppe, Bassanelli, Maria, Merler, Sara, Messina, Carlo, Küronya, Zsófia, Mosca, Alessandra, Bhuva, Dipen, Vau, Nuno, Incorvaia, Lorena, Rebuzzi, Sara Elena, Roviello, Giandomenico, Zabalza, Ignacio Ortego, Rizzo, Alessandro, Mollica, Veronica, Sorgentoni, Giulia, Monteiro, Fernando Sabino M., Montironi, Rodolfo, Battelli, Nicola, and Porta, Camillo

Published
2023
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19. Radiofrequency Ablation Provides Rapid and Durable Pain Relief for the Palliative Treatment of Lytic Bone Metastases Independent of Radiation Therapy: Final Results from the OsteoCool Tumor Ablation Post-Market Study

Author

Levy, Jason, David, Elizabeth, Hopkins, Thomas, Morris, Jonathan, Tran, Nam D., Farid, Hamed, Massari, Francesco, O’Connell, William G., Vogel, Alexander, Gangi, Afshin, Sunenshine, Peter, Dixon, Robert, Von der Höh, Nicolas, and Bagla, Sandeep

Published
2023
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20. Experimental Evidence that Empowerment May Drive Exploration in Sparse-Reward Environments

Author

Massari, Francesco, Biehl, Martin, Meeden, Lisa, and Kanai, Ryota

Subjects
Computer Science - Artificial Intelligence
Abstract

Reinforcement Learning (RL) is known to be often unsuccessful in environments with sparse extrinsic rewards. A possible countermeasure is to endow RL agents with an intrinsic reward function, or 'intrinsic motivation', which rewards the agent based on certain features of the current sensor state. An intrinsic reward function based on the principle of empowerment assigns rewards proportional to the amount of control the agent has over its own sensors. We implemented a variation on a recently proposed intrinsically motivated agent, which we refer to as the 'curious' agent, and an empowerment-inspired agent. The former leverages sensor state encoding with a variational autoencoder, while the latter predicts the next sensor state via a variational information bottleneck. We compared the performance of both agents to that of an advantage actor-critic baseline in four sparse reward grid worlds. Both the empowerment agent and its curious competitor seem to benefit to similar extents from their intrinsic rewards. This provides some experimental support to the conjecture that empowerment can be used to drive exploration., Comment: 6 pages, 3 figures, to be published in proceedings of the International Conference on Development and Learning 2021

Published
2021

22. Systemic Immune-Inflammation Index in Patients Treated With First-Line Immune Combinations for Metastatic Renal Cell Carcinoma: Insights From the ARON-1 Study

Author

Monteiro, Fernando Sabino Marques, Fiala, Ondřej, Massari, Francesco, Myint, Zin W., Kopecky, Jindrich, Kucharz, Jakub, Büttner, Thomas, Grande, Enrique, Bourlon, Maria Teresa, Molina-Cerrillo, Javier, Pichler, Renate, Buchler, Tomas, Seront, Emmanuel, Ansari, Jawaher, Bamias, Aristotelis, Bhuva, Dipen, Vau, Nuno, Porta, Camillo, Fay, Andre Poisl, and Santoni, Matteo

Published
2024
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24. Real-world Outcome of Patients with Advanced Renal Cell Carcinoma and Intermediate- or Poor-risk International Metastatic Renal Cell Carcinoma Database Consortium Criteria Treated by Immune-oncology Combinations: Differential Effectiveness by Risk Group?

Author

Santoni, Matteo, Buti, Sebastiano, Myint, Zin W., Maruzzo, Marco, Iacovelli, Roberto, Pichler, Martin, Kopecky, Jindrich, Kucharz, Jakub, Rizzo, Mimma, Galli, Luca, Büttner, Thomas, De Giorgi, Ugo, Kanesvaran, Ravindran, Fiala, Ondřej, Grande, Enrique, Zucali, Paolo Andrea, Kopp, Ray Manneh, Fornarini, Giuseppe, Bourlon, Maria T., Scagliarini, Sarah, Molina-Cerrillo, Javier, Aurilio, Gaetano, Matrana, Marc R., Pichler, Renate, Cattrini, Carlo, Büchler, Tomas, Massari, Francesco, Seront, Emmanuel, Calabrò, Fabio, Pinto, Alvaro, Berardi, Rossana, Zgura, Anca, Mammone, Giulia, Ansari, Jawaher, Atzori, Francesco, Chiari, Rita, Bamias, Aristotelis, Caffo, Orazio, Procopio, Giuseppe, Sunela, Kaisa, Bassanelli, Maria, Ortega, Cinzia, Grillone, Francesco, Landmesser, Johannes, Milella, Michele, Messina, Carlo, Küronya, Zsófia, Mosca, Alessandra, Bhuva, Dipen, Santini, Daniele, Vau, Nuno, Morelli, Franco, Incorvaia, Lorena, Rebuzzi, Sara Elena, Roviello, Giandomenico, Soares, Andrey, Bisonni, Renato, Bimbatti, Davide, Zabalza, Ignacio Ortego, Rizzo, Alessandro, Mollica, Veronica, Sorgentoni, Giulia, Monteiro, Fernando Sabino M., Battelli, Nicola, Bracarda, Sergio, and Porta, Camillo

Published
2024
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25. Avelumab First-line Maintenance for Advanced Urothelial Carcinoma: Analysis from JAVELIN Bladder 100 by Duration of First-line Chemotherapy and Interval Before Maintenance

Author

Sridhar, Srikala S., Powles, Thomas, Climent Durán, Miguel Á., Park, Se Hoon, Massari, Francesco, Thiery-Vuillemin, Antoine, Valderrama, Begoña P., Ullén, Anders, Tsuchiya, Norihiko, Aragon-Ching, Jeanny B., Gupta, Shilpa, Petrylak, Daniel P., Bellmunt, Joaquim, Wang, Jing, Laliberte, Robert J., di Pietro, Alessandra, Costa, Nuno, Grivas, Petros, Sternberg, Cora N., and Loriot, Yohann

Published
2024
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28. Avelumab Plus Intermittent Axitinib in Previously Untreated Patients with Metastatic Renal Cell Carcinoma. The Tide-A Phase 2 Study

Author

Iacovelli, Roberto, Ciccarese, Chiara, Buti, Sebastiano, Zucali, Paolo Andrea, Fantinel, Emanuela, Bimbatti, Davide, Verzoni, Elena, Accettura, Caterina, Bonomi, Lucia, Buttigliero, Consuelo, Fornarini, Giuseppe, Pipitone, Stefania, Atzori, Francesco, Masini, Cristina, Massari, Francesco, Primi, Francesca, Strusi, Alessandro, Giudice, Giulia Claire, Perrino, Matteo, Maruzzo, Marco, Milella, Michele, Giannarelli, Diana, Brunelli, Matteo, Procopio, Giuseppe, and Tortora, Giampaolo

Published
2024
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30. A macro agent and its actions

Author

Albantakis, Larissa, Massari, Francesco, Beheler-Amass, Maggie, and Tononi, Giulio

Subjects
Quantitative Biology - Neurons and Cognition, Computer Science - Artificial Intelligence, Computer Science - Neural and Evolutionary Computing, Quantitative Biology - Quantitative Methods
Abstract

In science, macro level descriptions of the causal interactions within complex, dynamical systems are typically deemed convenient, but ultimately reducible to a complete causal account of the underlying micro constituents. Yet, such a reductionist perspective is hard to square with several issues related to autonomy and agency: (1) agents require (causal) borders that separate them from the environment, (2) at least in a biological context, agents are associated with macroscopic systems, and (3) agents are supposed to act upon their environment. Integrated information theory (IIT) (Oizumi et al., 2014) offers a quantitative account of causation based on a set of causal principles, including notions such as causal specificity, composition, and irreducibility, that challenges the reductionist perspective in multiple ways. First, the IIT formalism provides a complete account of a system's causal structure, including irreducible higher-order mechanisms constituted of multiple system elements. Second, a system's amount of integrated information ($\Phi$) measures the causal constraints a system exerts onto itself and can peak at a macro level of description (Hoel et al., 2016; Marshall et al., 2018). Finally, the causal principles of IIT can also be employed to identify and quantify the actual causes of events ("what caused what"), such as an agent's actions (Albantakis et al., 2019). Here, we demonstrate this framework by example of a simulated agent, equipped with a small neural network, that forms a maximum of $\Phi$ at a macro scale., Comment: 18 pages, 5 figures; to appear as a chapter in "Top-Down Causation and Emergence" published by Springer as part of the Synthese Library Book Series; F.M. and M.B. contributed equally to this work

Published
2020

31. Site of metastasis and clinical outcomes in patients with advanced renal cell carcinoma treated with TKI monotherapy or combination therapy: A real-world analysis.

Author

Nuvola, Giacomo, primary, Navarro, Victor, additional, Mollica, Veronica, additional, Marmolejo Castañeda, David Humberto, additional, González, Macarena, additional, Morales-Barrera, Rafael, additional, Vega, Sharela, additional, Santoni, Matteo, additional, Catalan, Laia, additional, Trilla, Enrique, additional, Carles, Joan, additional, Massari, Francesco, additional, and Suárez, Cristina, additional

Published
2024
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32. TAMs PD-L1(+) in the reprogramming of germ cell tumors of the testis

Author

Melotti, Sofia, Ambrosi, Francesca, Franceschini, Tania, Giunchi, Francesca, Filippo, Giorgia Di, Franchini, Eugenia, Massari, Francesco, Mollica, Veronica, Tateo, Valentina, Bianchi, Federico Mineo, Colecchia, Maurizio, Acosta, Andres Martin, Lobo, João, Fiorentino, Michelangelo, and Ricci, Costantino

Published
2023
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33. Assessment of thrombectomy procedure difficulty by neurointerventionalists based on vessel geometry parameters from carotid artery 3D reconstructions

Author

Shazeeb, Mohammed Salman, Moholkar, Viraj, King, Robert M., Vedantham, Srinivasan, Vardar, Zeynep, Kraitem, Afif, Lindsay, Clifford, Anagnostakou, Vania, Singh, Jasmeet, Massari, Francesco, de Macedo Rodrigues, Katyucia, Naragum, Varun, Puri, Ajit S., Carniato, Sarena, Gounis, Matthew J., and Kühn, Anna Luisa

Published
2023
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35. Concomitant Use of Statins, Metformin, or Proton Pump Inhibitors in Patients with Advanced Renal Cell Carcinoma Treated with First-Line Combination Therapies

Author

Santoni, Matteo, Molina-Cerrillo, Javier, Myint, Zin W., Massari, Francesco, Buchler, Tomas, Buti, Sebastiano, Matrana, Marc R., De Giorgi, Ugo, Rizzo, Mimma, Zabalza, Ignacio Ortego, Galli, Luca, Zucali, Paolo Andrea, Aurilio, Gaetano, Incorvaia, Lorena, Bassanelli, Maria, Mammone, Giulia, Salfi, Alessia, Isella, Luca, Mollica, Veronica, Grande, Enrique, Porta, Camillo, and Battelli, Nicola

Published
2022
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37. Pivotal Trial of the Neuroform Atlas Stent for Treatment of Anterior Circulation Aneurysms

Author

Zaidat, Osama O, Hanel, Ricardo A, Sauvageau, Eric A, Aghaebrahim, Amin, Lin, Eugene, Jadhav, Ashutosh P, Jovin, Tudor G, Khaldi, Ahmad, Gupta, Rishi G, Johnson, Andrew, Frei, Donald, Loy, David, Malek, Adel, Toth, Gabor, Siddiqui, Adnan, Reavey-Cantwell, John, Thomas, Ajith, Hetts, Steven W, Jankowitz, Brian T, Gross, Bradley, Ducruet, Andrew, Panczkowski, David, Shoirah, Hazem, Al-Bayati, Alhamza, Weiner, Greg, Kenmuir, Cynthia, Tadi, Prasanna, Walker, Gregory, Johnson, K, Frei, Don, Bellon, Richard, Atchie, Benjamin, Kaminsky, Ian, Huddle, Dan, Bain, Mark, Rasmussen, Peter, Hussain, M Shazam, Moore, Nina, Masaryk, Thomas, Elgabaly, Mohamed, Cerejo, Russell, Hardman, Julian, John, Seby, Bauer, Andrew, Peih-Chir Tsai, Jenny, Levy, Elad, Snyder, Kenneth, Davies, Jason, Ogilvy, Christopher, Rivet, Dennis, Alexander, Michael, Moser, Franklin, Maya, Marcel, Schiraldi, Michael, Eboli, Paula, Caplan, Justin, Jiang, Bowen, Bender, Matthew, Colby, Geoffrey, Satti, Sudhakar, Sivapatham, Thinesh, Kung, David, Pukenas, Bryan, Hurst, Robert, Smith, Michelle J, Puri, Ajit, Massari, Francesco, Rex, David, Fraser, Justin, Grupke, Stephen, Alhajeri, Abdulnasser, Klucznik, Richard, Diaz, Orlando, Britz, Gavin, Zhan, Yi, Spiotta, Alejandro, Lena, Jonathan, Turk, Aquilla, Chaudry, Mohamad, Fargen, Kyle, Turner, Raymond, Kan, Peter, Duckworth, Edward, Asif Taqi, Muhammad, Hou, Samuel, Arthur, Adam S, Elijovich, Lucas, Hoit, Daniel, Nickele, Christopher, Vachhani, Jay, Thomas Doss, Vinodh, Crowley, Richard, Lopes, Demetrius, Chen, Michael, Hallam, Danial, Ghodke, Basavaraj, Kim, Louis, Callison, Richard, Alshekhlee, Amer, and Kale, Sushant

Subjects
Bioengineering, Stroke, Assistive Technology, Neurosciences, Clinical Research, Clinical Trials and Supportive Activities, Brain Disorders, Adult, Aged, Embolization, Therapeutic, Endovascular Procedures, Female, Humans, Intracranial Aneurysm, Male, Middle Aged, Stents, Treatment Outcome, angiography, intracranial aneurysm, middle cerebral artery, retreatment, stent, ATLAS Investigators, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurology & Neurosurgery
Abstract

Background and purposeStent-assisted coil embolization using the new generation Neuroform Atlas Stent System has shown promising safety and efficacy. The primary study results of the anterior circulation aneurysm cohort of the treatment of wide-neck, saccular, intracranial, aneurysms with the Neuroform Atlas Stent System (ATLAS trial [Safety and Effectiveness of the Treatment of Wide Neck, Saccular Intracranial Aneurysms With the Neuroform Atlas Stent System]) are presented.MethodsATLAS IDE trial (Investigational Device Exemption) is a prospective, multicenter, single-arm, open-label study of wide-neck (neck ≥4 mm or dome-to-neck ratio 50%) at the target location. The primary safety end point was any major stroke or ipsilateral stroke or neurological death within 12 months. Adjudication of the primary end points was performed by an independent Imaging Core Laboratory and the Clinical Events Committee.ResultsA total of 182 patients with wide-neck anterior circulation aneurysms at 25 US centers were enrolled. The mean age was 60.3±11.4 years, 73.1% (133/182) women, and 80.8% (147/182) white. Mean aneurysm size was 6.1±2.2 mm, mean neck width was 4.1±1.2 mm, and mean dome-to-neck ratio was 1.2±0.3. The most frequent aneurysm locations were the anterior communicating artery (64/182, 35.2%), internal carotid artery ophthalmic artery segment (29/182, 15.9%), and middle cerebral artery bifurcation (27/182, 14.8%). Stents were placed in the anticipated anatomic location in all patients. The study met both primary safety and efficacy end points. The composite primary efficacy end point of complete aneurysm occlusion (Raymond-Roy 1) without parent artery stenosis or aneurysm retreatment was achieved in 84.7% (95% CI, 78.6%-90.9%) of patients. Overall, 4.4% (8/182, 95% CI, 1.9%-8.5%) of patients experienced a primary safety end point of major ipsilateral stroke or neurological death.ConclusionsIn the ATLAS IDE anterior circulation aneurysm cohort premarket approval study, the Neuroform Atlas stent with adjunctive coiling met the primary end points and demonstrated high rates of long-term complete aneurysm occlusion at 12 months, with 100% technical success and

Published
2020

39. Comparative assessment of early mortality risk upon immune checkpoint inhibitors alone or in combination with other agents across solid malignancies: a systematic review and meta-analysis

Author

Viscardi, Giuseppe, Tralongo, Antonino C., Massari, Francesco, Lambertini, Matteo, Mollica, Veronica, Rizzo, Alessandro, Comito, Francesca, Di Liello, Raimondo, Alfieri, Salvatore, Imbimbo, Martina, Della Corte, Carminia M., Morgillo, Floriana, Simeon, Vittorio, Lo Russo, Giuseppe, Proto, Claudia, Prelaj, Arsela, De Toma, Alessandro, Galli, Giulia, Signorelli, Diego, Ciardiello, Fortunato, Remon, Jordi, Chaput, Nathalie, Besse, Benjamin, de Braud, Filippo, Garassino, Marina C., Torri, Valter, Cinquini, Michela, and Ferrara, Roberto

Published
2022
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42. Tumor growth rate to assess therapy response to immune-based combinations for metastatic renal cell carcinoma

Author

Mollica, Veronica, primary, Rosellini, Matteo, additional, Brocchi, Stefano, additional, Galuppi, Francesco, additional, Paccapelo, Alexandro, additional, Tateo, Valentina, additional, Marchetti, Andrea, additional, Tassinari, Elisa, additional, Mantuano, Francesco, additional, Santoni, Matteo, additional, and Massari, Francesco, additional

Published
2024
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43. The interaction between early life complications and a polygenic risk score for schizophrenia is associated with brain activity during emotion processing in healthy participants

Author

Toro, Veronica Debora, primary, Antonucci, Linda A., additional, Quarto, Tiziana, additional, Passiatore, Roberta, additional, Fazio, Leonardo, additional, Ursini, Gianluca, additional, Chen, Qiang, additional, Masellis, Rita, additional, Torretta, Silvia, additional, Sportelli, Leonardo, additional, Kikidis, Gianluca Christos, additional, Massari, Francesco, additional, D'Ambrosio, Enrico, additional, Rampino, Antonio, additional, Pergola, Giulio, additional, Weinberger, Daniel R., additional, Bertolino, Alessandro, additional, and Blasi, Giuseppe, additional

Published
2024
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47. Adjuvant atezolizumab versus placebo for patients with renal cell carcinoma at increased risk of recurrence following resection (IMmotion010): a multicentre, randomised, double-blind, phase 3 trial

Author

Pal, Sumanta Kumar, Uzzo, Robert, Karam, Jose Antonio, Master, Viraj A, Donskov, Frede, Suarez, Cristina, Albiges, Laurence, Rini, Brian, Tomita, Yoshihiko, Kann, Ariel Galapo, Procopio, Giuseppe, Massari, Francesco, Zibelman, Matthew, Antonyan, Igor, Huseni, Mahrukh, Basu, Debasmita, Ci, Bo, Leung, William, Khan, Omara, Dubey, Sarita, and Bex, Axel

Published
2022
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