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6. Generalized pustular psoriasis: A nationwide population‐based study using the National Health Data System in France.

Author

Viguier, Manuelle, Bentayeb, Malek, Azzi, Jessica, de Pouvourville, Gérard, Gloede, Tristan, Langellier, Bérengère, Massol, Jacques, Medina, Patricia, Thoma, Christian, and Bachelez, Hervé

Subjects
PYODERMA gangrenosum, PROPENSITY score matching, PSORIASIS, INTENSIVE care units, FRENCH people, SKIN diseases
Abstract

Background: GPP is a rare, chronic, neutrophilic skin disease, with limited real‐world data characterizing patients with flares and the impact of flares on disease progression and morbidity. Objective: Describe the clinical characteristics of patients with GPP, comorbidities, disease epidemiology and frequency and severity of flares, and compare patients with GPP with a matched severe psoriasis population. Methods: In this population‐based real‐world cohort study an algorithm was developed to identify patients with GPP flares. Three cohorts were identified using the Système National des Données de Santé (SNDS) database covering almost the entire French population; a prevalent cohort (2010–2018), an incident cohort (2012–2015). A severe psoriasis cohort was compared with the GPP incident cohort using propensity score matching. Results: The prevalent and incident cohorts comprised 4195 and 1842 patients, respectively. In both cohorts, mean age was 58 years; 53% were male. Comorbidities were significantly more common in the incident cohort versus matched psoriasis cohort, respectively, including hypertension (44% vs. 26%), ischaemic heart disease (26% vs. 18%) and hyperlipidaemia (25% vs. 15%). In the incident cohort, the flare rate was 0.1 flares/person‐year and 0.4 flares/person‐year among the 569 out of 1842 patients hospitalized with flares. These patients had a mean (±SD) stay of 11.6 ± 10.4 days; 25% were admitted to the intensive care unit. In 2017, the cumulative incidence and cumulative GPP age–sex standardized prevalence were 7.1 and 45.2 per million, respectively. Conclusions: Patients with GPP had a distinct comorbidity profile compared to patients with severe psoriasis, and GPP flares were associated with long hospitalizations. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Assessment and Non-clinical Impact of Medical Devices

Author

Dervaux, Benoît, Szwarcensztein, Karine, Josseran, Anne, Barna, Alexandre, Carbonneil, Cédric, Chevrie, Karine, Debroucker, Frédérique, Grumblat, Anne, Grumel, Olivier, Massol, Jacques, Maugendre, Philippe, Méchin, Hubert, Orlikowski, David, Roussel, Christophe, Rumeau-Pichon, Catherine, Sales, Jean-Patrick, and Vicaut, Eric

Published
2015
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9. Evaluation et impact non clinique des dispositifs médicaux

Author

Dervaux, Benoît, Szwarcensztein, Karine, Josseran, Anne, Barna, Alexandre, Carbonneil, Cédric, Chevrie, Karine, Debroucker, Frédérique, Grumblat, Anne, Grumel, Olivier, Massol, Jacques, Maugendre, Philippe, Méchin, Hubert, Orlikowski, David, Roussel, Christophe, Rumeau-Pichon, Catherine, Sales, Jean-Patrick, and Vicaut, Eric

Published
2015
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14. Guide de la Haute autorité de santé (HAS) : les études post-inscription sur les technologies de santé (médicaments, dispositifs médicaux et actes) : principes et méthodes

Author

Auquier, Pascal, Baumelou, Elisabeth, de Bels, Frédéric, Bene, Marie-Christine, Bernard, Alain, Boissel, Jean-Pierre, Carrere, Marie-Odile, Czernichow, Pierre, Dervaux, Benoit, Eschwege, Eveline, Fabbro-Peray, Pascale, Falissard, Bruno, Fourrier, Annie, Guillemot, Didier, Lacoin, François, Lapeyre-Mestre, Maryse, Maison, Patrick, Massol, Jacques, Oger, Emmanuel, Roudot-Thoraval, Françoise, Trouiller, Patrice, Vray, Muriel, Zureik, Mahmoud, Stamenkovic, Sophie, Solesse, Anne, Zanetti, Laura, and Zagury, Pascale

Published
2012
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15. Apport de la modélisation et des populations virtuelles pour transposer les résultats des essais cliniques à la vie réelle et éclairer la décision publique

Author

Ferrante, Béatrice Augendre, Benichou, Jacques, Berdeaux, Gilles, Blin, Patrick, Borel, Thomas, Rey-Coquais, Cecile, Joubert, Jean-Michel, Meyer, François, Muller, Sophie, Pibouleau, Leslie, Pinet, Marion, Vidal, Christel, Gueyffier, François, Strang, Catherine Brun, França, Lionel Riou, and Massol, Jacques

Published
2012
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16. Contribution of Modeling Approaches and Virtual Populations in Transposing the Results of Clinical Trials into Real Life and in Enlightening Public Health Decisions

Author

Ferrante, Béatrice Augendre, Benichou, Jacques, Berdeaux, Gilles, Blin, Patrick, Borel, Thomas, Rey-Coquais, Cecile, Joubert, Jean-Michel, Meyer, François, Muller, Sophie, Pibouleau, Leslie, Pinet, Marion, Vidal, Christel, Gueyffier, François, Strang, Catherine Brun, França, Lionel Riou, and Massol, Jacques

Published
2012
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21. Définition des populations cibles des médicaments : comment anticiper au mieux la définition des populations cibles en vue du remboursement ?

Author

Alperovitch, Annick, Auquier, Pascal, Bamberger, Marion, Banzet, Marie-Noëlle, Boissel, Jean-Pierre, Borel, Thomas, Denis, Catherine, Flahault, Antoine, Gourlay, Marie-Laurence, Jolliet, Pascale, Joubert, Jean-Michel, Lièvre, Michel, Maison, Patrick, Meyer, Arlette, Moore, Nicholas, Prestat-Sledziewski, Laure, Rouby, Frank, Schmidely, Nathalie, Solesse, Anne, Teisseire, Bernard, Vasmant, Daniel, Veron, Didier, Villani, Patrick, Zanetti, Laura, Zureik, Mahmoud, Zylberman, Myriam, Homers, Françoise F., Massol, Jacques, and Maillère, Patricia

Published
2010
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22. How to Best Define Target Populations of Medicines in View of Their Coverage by the National Health Insurance Scheme?

Author

Alperovitch, Annick, Auquier, Pascal, Bamberger, Marion, Banzet, Marie-Noëlle, Boissel, Jean-Pierre, Borel, Thomas, Denis, Catherine, Flahault, Antoine, Gourlay, Marie-Laurence, Jolliet, Pascale, Joubert, Jean-Michel, Lièvre, Michel, Maison, Patrick, Meyer, Arlette, Moore, Nicholas, Prestat-Sledziewski, Laure, Rouby, Frank, Schmidely, Nathalie, Solesse, Anne, Teisseire, Bernard, Vasmant, Daniel, Veron, Didier, Villani, Patrick, Zanetti, Laura, Zureik, Mahmoud, Zylberman, Myriam, Hamers, Françoise F., Massol, Jacques, and Maillère, Patricia

Published
2010
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23. Études post-AMM : apport dans la réinscription des produits

Author

Allicar, Marie-Pierre, Ameye, Véronique, Avouac, Bernard, Banzet, Marie-Noëlle, Becquemont, Laurent, Blin, Patrick, Duguay, Corinne, Fagnani, Francis, Girault, Danièle, Haim, Muriel, Hamers, Françoise, Lalaude, Olivier, Lamarque, Véronique, Maillere, Patricia, Massol, Jacques, Maugendre, Philippe, Meyer, Arlette, Moreau-Defarges, Thierry, Pathak, Atul, Perillat, Anne, Ravoire, Sophie, Spriet, Alain, Tardieu, Sophie, Teisseire, Bernard, MoniqueWeber, Zanetti, Laura, Molimard, Mathieu, Bamberger, Marion, and Vray, Muriel

Published
2009
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24. Value of Post-Registration Studies for Reimbursement Renewal

Author

Allicar, Marie-Pierre, Ameye, Véronique, Avouac, Bernard, Banzet, Marie-Noëlle, Becquemont, Laurent, Blin, Patrick, Duguay, Corinne, Fagnani, Francis, Girault, Danièle, Haim, Muriel, Hamers, Françoise, Lalaude, Olivier, Lamarque, Véronique, Maillere, Patricia, Massol, Jacques, Maugendre, Philippe, Meyer, Arlette, Moreau-Defarges, Thierry, Pathak, Atul, Perillat, Anne, Ravoire, Sophie, Spriet, Alain, Tardieu, Sophie, Teisseire, Bernard, Weber, Monique, Zanetti, Laura, Molimard, Mathieu, Bamberger, Marion, and Vray, Muriel

Published
2009
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25. 26591 Characterization of flares in patients with generalized pustular psoriasis—A population-based study from the French National Health Data System database (SNDS)

Author

Bachelez, Hervé, primary, Massol, Jacques, additional, de Pouvourville, Gérard, additional, Gloede, Tristan, additional, Medina, Patricia, additional, Esser, Dirk, additional, Bentayeb, Malek, additional, Le Lay, Katell, additional, Thoma, Christian, additional, and Viguier, Manuelle, additional

Published
2021
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26. Epidemiology, Mortality and Healthcare Resource Utilization Associated With Systemic Sclerosis-Associated Interstitial Lung Disease in France

Author

Cottin, Vincent, primary, Larrieu, Sophie, additional, Boussel, Loic, additional, Si-Mohamed, Salim, additional, Bazin, Fabienne, additional, Marque, Sébastien, additional, Massol, Jacques, additional, Thivolet-Bejui, Françoise, additional, Chalabreysse, Lara, additional, Maucort-Boulch, Delphine, additional, Jouneau, Stéphane, additional, Hachulla, Eric, additional, Chollet, Julien, additional, and Nasser, Mouhamad, additional

Published
2021
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28. Additional file 1 of Estimates of epidemiology, mortality and disease burden associated with progressive fibrosing interstitial lung disease in France (the PROGRESS study)

Author

Nasser, Mouhamad, Larrieu, Sophie, Loic Boussel, Si-Mohamed, Salim, Bazin, Fabienne, Marque, Sébastien, Massol, Jacques, Thivolet-Bejui, Françoise, Chalabreysse, Lara, Maucort-Boulch, Delphine, Hachulla, Eric, Jouneau, Stéphane, Lay, Katell Le, and Cottin, Vincent

Subjects
Data_FILES
Abstract

Additional file 1. Additional methods and results.

Published
2021
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30. Recherche non interventionnelle et soins courants : définition, aspects réglementaires, difficultés et propositions

Author

Barraud, Béatrice, Becquemont, Laurent, Billon, Nathalie, Birraux, Guillaume, Cellier, Dominic, Childs, Mark, Daurat, Véronique, Deplanque, Dominique, Depont-Hebert, Fanny, Fourrier-Reglat, Annie, Frija-Orvoen, Elisabeth, Gaudin, Anne-Françoise, Esteller, Sylvie Hansel, Lalaude, Olivier, Laurent-Vo, Jean-Marc, Lebrun, Eléonore, Lechat, Philippe, Libersa, Christian, Massol, Jacques, Maugendre, Philippe, Montestruc, François, Rey-Quinio, Catherine, Rusch, Philippe, Sibenaler, Claire, Simon, Tabassome, Tardieu, Sophie, Van Ganse, Eric, Vial, Thierry, Zanetti, Laura, Lemaire, François, Ravoire, Sophie, and Golinelli, Danielle

Published
2008
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31. Non-interventional Research and Usual Care: Definition, Regulatory Aspects, Difficulties and Recommendations

Author

Barraud, Béatrice, Becquemont, Laurent, Billon, Nathalie, Birraux, Guillaume, Cellier, Dominic, Childs, Mark, Daurat, Véronique, Deplanque, Dominique, Depont-Hebert, Fanny, Fourrier-Reglat, Annie, Frija-Orvoen, Elisabeth, Gaudin, Anne-Françoise, Esteller, Sylvie Hansel, Lalaude, Olivier, Laurent-Vo, Jean-Marc, Lebrun, Eléonore, Lechat, Philippe, Libersa, Christian, Massol, Jacques, Maugendre, Philippe, Montestruc, François, Rey-Quinio, Catherine, Rusch, Philippe, Sibenaler, Claire, Simon, Tabassome, Tardieu, Sophie, Van Ganse, Eric, Vial, Thierry, Zanetti, Laura, Lemaire, François, Ravoire, Sophie, and Golinelli, Danielle

Published
2008
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32. How to Anticipate the Assessment of the Public Health Benefit of New Medicines?

Author

Alperovitch, A., Bamberger, M., Begaud, B., Blin, O., Blin, P., Breart, G., Brun Strang, C., Buyse, M., Castot, A., Chauvenet, M., Chicoye, A., David, N., De Bels, F., De Sahb Berkovitch, R., Dohin, E., Fagnani, F., Falissard, B., Gastaldi-Menager, C., Giri, I., Haim, M., Joubert, J.M., Lapeyre-Mestre, M., Lassale, C., Marchant Ramirez, I., Meyer, F., Micallef, J., Mollimard, M., Moreau-Defarges, T., Pazart, L., Perret, L., Pigeon, M., Rumeau Pichon, C., Tcheng, Ph., Woler, M., Zanetti, L., Zylberman, M., Massol, Jacques, Puech, Alain, and Boissel, Jean-Pierre

Published
2007
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33. Comment anticiper l’évaluation de l’intérêt de santé publique des médicaments ?

Author

Alperovitch, A., Bamberger, M., Bégaud, B., Blin, O., Blin, P., Bréart, G., Brun Strang, C., Buyse, M., Castot, A., Chauvenet, M., Chicoye, A., David, N., De Bels, F., De Sahb Berkovitch, R., Dohin, E., Fagnani, F., Falissard, B., Gastaldi-Menager, C., Giri, I., Haim, M., Joubert, J.M., Lapeyre-Mestre, M., Lassale, C., Marchant Ramirez, I., Meyer, F., Micallef, J., Mollimard, M., Moreau-Defarges, T., Pazart, L., Perret, L., Pigeon, M., Rumeau Pichon, C., Tcheng, Ph., Woler, M., Zanetti, L., Zylberman, M., Massol, Jacques, Puech, Alain, and Boissel, Jean-Pierre

Published
2007
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38. Utilisation des études étrangères : transposition des résultats, prédiction des effets thérapeutiques en population française, modélisation de l’Intérêt de Santé Publique

Author

Abenhaïm, L., Ambrosi, P., Bardou, M., Boissel, J-P., Brun, C., Castaigne, A., Chassany, O., de Bels, F., de Sahb-Berkovitch, R., El-Hasnaoui, A., Fagagni, F., Fourrier-Reglat, A., Gastaldi-Meninger, C., Goehrs, J.-M., Gueffier, F., Hotton, J.-M., Ichou, F., Lechat, P., Maillère, P., Meyer, F., Micallef, J., Molimard, M., Moreau-Defarges, T., Perillat, A., Pigeon, M., Poitrinal, P., Rey-Quino, C., Ricordeau, P., Ropers, J., Massol, Jacques, Zylberman, Myriam, and Goehrs, Jean-Marie

Published
2006
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39. Use of the Foreign Studies: Transposition of the Results, Prediction of the Therapeutic Effects in the French Population, Modelling of the Public Health Interest

Author

Abenhaïm, L., Ambrosi, P., Bardou, M., Boissel, J-P., Brun, C., Castaigne, A., Chassany, O., de Bels, F., de Sahb Berkovitch, R., El Hasnaoui, A., Fagagni, F., Fourrier-Reglat, A., Gastaldi-Meninger, C., Goehrs, J.-M., Gueffier, F., Hotton, J.-M., Ichou, F., Lechat, P., Maillère, P., Meyer, F., Micallef, J., Molimard, M., Moreau-Defarges, T., Perillat, A., Pigeon, M., Poitrinal, P., Rey-Quino, C., Ricordeau, P., Ropers, J., Massol, Jacques, Zylberman, Myriam, and Goehrs, Jean-Marie

Published
2006
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41. Epidemiology and mortality of non-idiopathic pulmonary fibrosis (IPF) progressive fibrosing interstitial lung disease (PF-ILD) using the French national health insurance system (SNDS) database in France: the PROGRESS study

Author

Nasser, Mouhamad, primary, Larrieu, Sophie, additional, Boussel, Loïc, additional, Si-Mohamed, Salim, additional, Diaz, Fabienne, additional, Marque, Sébastien, additional, Massol, Jacques, additional, Revel, Didier, additional, Thivolet-Bejui, Francoise, additional, Chalabreysse, Lara, additional, Maucort-Boulch, Delphine, additional, and Cottin, Vincent, additional

Published
2020
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42. Prevalence and mortality of systemic sclerosis-associated interstitial lung disease (SSc-ILD) using the French national health insurance system (SNDS) database in France

Author

Nasser, Mouhamad, primary, Larrieu, Sophie, additional, Boussel, Loic, additional, Si-Mohamed, Salim, additional, Bazin, Fabienne, additional, Marque, Sébastien, additional, Massol, Jacques, additional, Revel, Didier, additional, Thivolet-Bejui, Francoise, additional, Chalabreysse, Lara, additional, Maucort-Boulch, Delphine, additional, Hachulla, Eric, additional, Jouneau, Stéphane, additional, and Cottin, Vincent, additional

Published
2020
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49. Who seeks primary care for musculoskeletal disorders (MSDs) with physicians prescribing homeopathic and other complementary medicine? Results from the EPI3-LASER survey in France

Author

Magnier Anne-Marie, Guillemot Didier, Duru Gérard, Massol Jacques, Bénichou Jacques, Rouillon Frédéric, Lert France, Bégaud Bernard, Avouac Bernard, Rossignol Michel, Grimaldi-Bensouda Lamiae, and Abenhaim Lucien

Subjects
Diseases of the musculoskeletal system, RC925-935
Abstract

Abstract Background There is a paucity of information describing patients with musculoskeletal disorders (MSDs) using complementary and alternative medicines (CAMs) and almost none distinguishing homeopathy from other CAMs. The objective of this study was to describe and compare patients with MSDs who consulted primary care physicians, either certified homeopaths (Ho) or regular prescribers of CAMs in a mixed practice (Mx), to those consulting physicians who strictly practice conventional medicine (CM), with regard to the severity of their MSD expressed as chronicity, co-morbidity and quality of life (QOL). Methods The EPI3-LASER study was a nationwide observational survey of a representative sample of general practitioners and their patients in France. The sampling strategy ensured a sufficient number of GPs in each of the three groups to allow comparison of their patients. Patients completed a questionnaire on socio-demographics, lifestyle and QOL using the Short Form 12 (SF-12) questionnaire. Chronicity of MSDs was defined as more than twelve weeks duration of the current episode. Diagnoses and co-morbidities were recorded by the physician. Results A total of 825 GPs included 1,692 MSD patients (predominantly back pain and osteoarthritis) were included, 21.6% in the CM group, 32.4% Ho and 45.9% Mx. Patients in the Ho group had more often a chronic MSD (62.1%) than the CM (48.6%) or Mx (50.3%) groups, a result that was statistically significant after controlling for patients' characteristics (Odds ratio = 1.43; 95% confidence interval (CI): 1.07 - 1.89). Patients seen by homeopaths or mixed practice physicians who were not the regular treating physician, had more often a chronic MSD than those seen in conventional medicine (Odds ratios were1.75; 95% CI: 1.22 - 2.50 and 1.48; 95% CI: 1.06 - 2.12, respectively). Otherwise patients in the three groups did not differ for co-morbidities and QOL. Conclusion MSD patients consulting primary care physicians who prescribed homeopathy and CAMs differed from those seen in conventional medicine. Chronic MSD patients represented a greater proportion of the clientele in physicians offering alternatives to conventional medicine. In addition, these physicians treated chronic patients as consulting rather than regular treating physicians, with potentially important impacts upon professional health care practices and organisation.

Published
2011
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50. L'« Evidence Based Medicine » (EBM) : utile reflet de la réalité ou dangereux miroir de sorcière ?

Author

Massol, Jacques, Université Paris 1 Panthéon-Sorbonne - UFR Philosophie (UP1 UFR10), Université Paris 1 Panthéon-Sorbonne (UP1), and Jean Gayon

Subjects
Réalité, [SHS.PHIL]Humanities and Social Sciences/Philosophy, Vérité, Épidémiologie clinique, Preuves, Médecine fondée sur les preuves
Abstract

Modèle dominant actuel de la Médecine dans bon nombre de pays au monde, l’«Evidence Based Medicine » (EBM), dénommée ainsi, par Gordon Guyatt en 1992, a été difficilement traduite en français. On parlera surtout de Médecine fondée sur les preuves. Apparue au Canada, dans le sillage de l’épidémiologie clinique, l’EBM a été développée et promue tout d’abord comme outil d’apprentissage de la Médecine par le groupe de travail international « Evidence based working group ». Il s’agissait alors de procurer aux étudiants un outil capable de distinguer les études probantes au sein d’une littérature médicale qui commençait à foisonner et de développer du même coup leur esprit critique à partir des articles scientifiques (sources primaires d’information). Mais l’EBM est bien vite devenue la théorie d’une pratique, une façon d’exercer la médecine clinique. On est ainsi passé rapidement d’une méthode de tri de la littérature médicale « scientifique » selon un certain niveau de preuve, à l’exploitation des résultats des études issues de ce tri (source secondaire d’information) : revues systématiques de la littérature, recommandations de bonne pratique et autres documents en vue d'améliorer les décisions cliniques mais aussi en tant qu'instruments de régulation des pratiques, des produits et des actes.

Published
2016

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