Search

Your search keyword '"Massoud, Salah S."' showing total 459 results
Start Over Author "Massoud, Salah S."
459 results on '"Massoud, Salah S."'

6. Structurally diverse zinc(II) complexes containing tripodal tetradentate phenoxido-amines with promising antiproliferative effects.

Author

Massoud, Salah S., Mautner, Franz A., Louka, Febee R., Salem, Nahed M. H., Fischer, Roland C., Torvisco, Ana, Vančo, Ján, Belza, Jan, Dvořák, Zdeněk, and Trávníček, Zdeněk

Subjects
*CELL cycle, *CYTOTOXINS, *ZINC, *LIGANDS (Biochemistry), *MEMBRANE potential, *MITOCHONDRIAL membranes, *LIGANDS (Chemistry), *ZINC compounds
Abstract

Structurally diverse zinc(II) complexes with tripodal tetradentate phenolic-amines of variable substituents in the phenol and amine moieties were synthesized and thoroughly characterized. The two dinuclear [Zn2(L1)2](ClO4)2·MeOH (1), [Zn2(L2)2](ClO4)2 (2), and four mononuclear [Zn(L3)(H2O)]·MeOH (3), [Zn(L4)] (4), [Zn(L5)] (5) and [Zn(L6)] (6) complexes revealed distorted octahedral, trigonal–bipyramidal or tetrahedral geometries. The free HL1 and H2L3–6 ligands, and complexes 1–6 were evaluated for in vitro cytotoxicity against human cancer cell lines (A2780, A2780R, PC-3 and 22Rv1) and normal healthy MRC-5 cells. Overall results revealed high-to-moderate cytotoxicity (with the best IC50 values for complex 6 ranging from 2.4 to 4.5 μM), which is however, significantly higher than that of the reference drug cisplatin. The moderately active complexes 1–4 showed considerable selectivity on A2780 cells (IC50 ≈ 16.3–19.5 μM) over MRC-5 ones (with IC50 >50 μM for 1, 2 and 4, and with IC50 >25 μM for 3). The complexes 1, 2, and 6 and the ligand H2L6 were chosen for subsequent deeper biological evaluations. Their time-resolved cellular uptake and other cellular effects in A2780 cells were studied, such as cell cycle profile, intracellular ROS production, induction of apoptosis and activation of caspases 3/7. Complexes 1 and 2 caused significant G0/G1 cell cycle arrest in A2780 cells and antioxidant effects at normal conditions. They showed only limited effects on cellular processes connected with cytotoxicity, i.e. induction of apoptosis, depletion of mitochondrial membrane potential, and autophagy. These findings can be at least partly attributed to the low ability of the complexes to enter the A2780 cells and the depression of metabolic activity of the target cancer cells. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

26. Structure and magnetic characterization of some bicompartmental [N6O2] divalent metal(II) complexes using bis(phenolato) ligands bearing two pendant bis(pyridyl) amine arms.

Author

Mautner, Franz A., Fischer, Roland C., Torvisco, Ana, Nakashima, Kai, Handa, Makoto, Mikuriya, Masahiro, Salem, Nahed M. H., Overby, Gabriel J., Maier, Madison R., Louka, Febee R., and Massoud, Salah S.

Subjects
MAGNETIC structure, LIGANDS (Chemistry), COPPER, METALS, MAGNETIC susceptibility, MAGNETIC measurements, ATOMS, PROTON transfer reactions
Abstract

Reactions of the bicompartmental bis(phenolato) compound 6,6′-methylenebis(2-((bis(pyridin-2-ylmethyl)amino)methyl)-4-chlorophenol)hemihydrate (H2L ½H2O) with 3d metal(II) ions afforded novel fully structurally characterized bridged acetato dinuclear complexes [Mn2(HL)(μ1,2-OAc)2]PF6 (1) [Zn2(HL)(μ1,2-OAc)(H2O)0.75(MeOH)0.25](PF6)2·0.45(H2O) (5) and [Cd2(HL)(μ1,1,2-OAc)(OAc)(H2O)]PF6·H2O (6) as well as the polymeric bridged-azido tetranuclear catena-[Cu4(HL)2(μ1,1-N3)2(μ1,3-N3)2](NO3)2·5H2O (4). The complex [Cu4(HL)2(ClO4)3(H2O)5](ClO4)3·5H2O (2) was partially characterized. In addition, three more dinuclear complexes [Cu2(H2L)(NO3)2(H2O)2](NO3)2 (3), [Cu2(HL)(OAc)(CH3OH)](PF6)2 (7) and [Cu2(HL)(NCS)2]NO3·2H2O (8) were also isolated. All complexes were characterized by CHN elemental analysis, IR and UV-Vis spectroscopy, ESI-MS, conductivity measurements and X-ray single crystal crystallography for compounds 1, 4, 5 and 6, where the bis(phenolato) ligand displayed different deprotonation (H2L, HL− and L2−). The magnetic susceptibility measurements over the temperature range 2–300 K revealed very weak antiferromagnetic coupling in dimanganese(II) 1 (J = −1.64(1) cm−1) and almost negligible magnetic interaction in dicopper(II) 2 (J = 0(3) cm−1). In the azido catena-[Cu4(HL)2(μ1,1-N3)2(μ1,3-N3)2](NO3)2·5H2O (4) complex, the J value of −133(3) cm−1 was obtained upon moderate-to-strong antiferromagnetic coupling through the di-μ1,3-N3-bridged dicopper(II) unit with no magnetic interaction between the two copper(II) ions in the di-μ1,1-N3-bridged unit. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

27. Structure and magnetic characterization of some bicompartmental [N6O2] divalent metal(ii) complexes using bis(phenolato) ligands bearing two pendant bis(pyridyl) amine arms

Author

Mautner, Franz A., primary, Fischer, Roland C., additional, Torvisco, Ana, additional, Nakashima, Kai, additional, Handa, Makoto, additional, Mikuriya, Masahiro, additional, Salem, Nahed M. H., additional, Overby, Gabriel J., additional, Maier, Madison R., additional, Louka, Febee R., additional, and Massoud, Salah S., additional

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results