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1. Parent-Mediated Interventions for Infants under 24 Months at Risk for Autism Spectrum Disorder: A Systematic Review of Randomized Controlled Trials

Author

Law, Mei L., Singh, Jatinder, Mastroianni, Mathilde, and Santosh, Paramala

Abstract

Prodromal symptoms of Autism Spectrum Disorder (ASD) have been detected within the first year of life. This review evaluated evidence from randomized controlled trials (RCTs) of parent-mediated interventions for infants under 24 months who are at risk for ASD. Electronic databases, including grey literature, were searched up till November 2019. Seven RCTs were identified. There was substantial heterogeneity in recruitment, outcome measures and effect size calculations. Interventions did not reduce the risk of later ASD diagnosis and post-intervention effects on infant outcomes were inconsistent, with five studies reporting significant improvements across both treatment and control groups. Moderate level of evidence of intervention effects on parental interaction skills and the small number of RCTs, and significant limitations restrict generalizability across studies.

Published
2022
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2. Different whole-brain functional connectivity correlates of reactive-proactive aggression and callous-unemotional traits in children and adolescents with disruptive behaviors

Author

Werhahn, Julia E., Smigielski, Lukasz, Sacu, Seda, Mohl, Susanna, Willinger, David, Naaijen, Jilly, Mulder, Leandra M., Glennon, Jeffrey C., Hoekstra, Pieter J., Dietrich, Andrea, Deters, Renee Kleine, Aggensteiner, Pascal M., Holz, Nathalie E., Baumeister, Sarah, Banaschewski, Tobias, Saam, Melanie C., Schulze, Ulrike M.E., Lythgoe, David J., Sethi, Arjun, Craig, Michael, Mastroianni, Mathilde, Sagar-Ouriaghli, Ilyas, Santosh, Paramala J., Rosa, Mireia, Bargallo, Nuria, Castro-Fornieles, Josefina, Arango, Celso, Penzol, Maria J., Zwiers, Marcel P., Franke, Barbara, Buitelaar, Jan K., Walitza, Susanne, and Brandeis, Daniel

Published
2023
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3. Development and Psychometric Properties of a New Questionnaire to Assess Mental Health and Concerning Behaviors in Children and Young People with Autism Spectrum Disorder (ASD): The Assessment of Concerning Behavior (ACB) Scale

Author

Tarver, Joanne, Vitoratou, Silia, Mastroianni, Mathilde, Heaney, Natalie, Bennett, Eleanor, Gibbons, Felicity, Fiori, Federico, Absoud, Michael, Ramasubramanian, Lakshmi, Simonoff, Emily, and Santosh, Paramala

Abstract

Although 70% of autistic children and young people meet criteria for co-occurring psychiatric conditions, there are few screening measures specifically for autistic individuals. We describe the development and validation of the Assessment of Concerning Behavior (ACB), an instrument co-developed with the autistic community to assess mental health and problematic/risky behaviors. Items include descriptions to facilitate symptom recognition by autistic people, and carers/professionals. The ACB was completed by 255 parents, 149 autistic children and young people and 30 teachers. Internal consistency, stability and validity was assessed. The ACB parent-version fit a two-factor model (internalizing and externalizing problems) and showed adequate test-retest reliability, internal consistency and construct validity. The ACB is a promising new measure for research and clinical use in autism.

Published
2021
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4. Leaving child and adolescent mental health services in the MILESTONE cohort: a longitudinal cohort study on young people's mental health indicators, care pathways, and outcomes in Europe

Author

Appleton, Rebecca, Davidović, Nikolina, Ferrari, Sabrina, Fiori, Federico, Gatherer, Charlotte, Hendrickx, Gaëlle, Holme, Ingrid, Jardri, Renaud, Kolozsvari, Alfred, Lievesley, Kate, Mastroianni, Mathilde, Maurice, Virginie, Morini, Giorgia, Parenti, Aesa, Russet, Frédérick, Saam, Melanie, Sagar-Ouriaghli, Ilyas, Sartor, Anne, Signorini, Giulia, Singh, Jatinder, Tah, Priya, Tuffrey, Amanda, van Amelsvoort, Therese AMJ, Varvara, Pamela, Vicari, Stefano, Walker, Leanne, Wilson, Anna, Jerkovic, Helena, Gerritsen, Suzanne E, van Bodegom, Larissa S, Overbeek, Mathilde M, Maras, Athanasios, Verhulst, Frank C, Wolke, Dieter, Rizopoulos, Dimitris, de Girolamo, Giovanni, Franić, Tomislav, Madan, Jason, McNicholas, Fiona, Paul, Moli, Purper-Ouakil, Diane, Santosh, Paramala J, Schulze, Ulrike M E, Singh, Swaran P, Street, Cathy, Tremmery, Sabine, Tuomainen, Helena, and Dieleman, Gwendolyn C

Published
2022
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5. Aggression subtypes relate to distinct resting state functional connectivity in children and adolescents with disruptive behavior

Author

Werhahn, Julia E., Mohl, Susanna, Willinger, David, Smigielski, Lukasz, Roth, Alexander, Hofstetter, Christoph, Stämpfli, Philipp, Naaijen, Jilly, Mulder, Leandra M., Glennon, Jeffrey C., Hoekstra, Pieter J., Dietrich, Andrea, Kleine Deters, Renee, Aggensteiner, Pascal M., Holz, Nathalie E., Baumeister, Sarah, Banaschewski, Tobias, Saam, Melanie C., Schulze, Ulrike M. E., Lythgoe, David J., Sethi, Arjun, Craig, Michael C., Mastroianni, Mathilde, Sagar-Ouriaghli, Ilyas, Santosh, Paramala J., Rosa, Mireia, Bargallo, Nuria, Castro-Fornieles, Josefina, Arango, Celso, Penzol, Maria J., Zwiers, Marcel P., Franke, Barbara, Buitelaar, Jan K., Walitza, Susanne, and Brandeis, Daniel

Published
2021
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6. Specific cortical and subcortical alterations for reactive and proactive aggression in children and adolescents with disruptive behavior

Author

Naaijen, Jilly, Mulder, Leandra M, Ilbegi, Shahrzad, de Bruijn, Sanne, Kleine-Deters, Renee, Dietrich, Andrea, Hoekstra, Pieter J, Marsman, Jan-Bernard C, Aggensteiner, Pascal M, Holz, Nathalie E, Boettinger, Boris, Baumeister, Sarah, Banaschewski, Tobias, Saam, Melanie C, M E Schulze, Ulrike, Santosh, Paramala J, Sagar-Ouriaghli, Ilyas, Mastroianni, Mathilde, Castro Fornieles, Josefina, Bargallo, Nuria, Rosa, Mireia, Arango, Celso, Penzol, Maria J, Werhahn, Julia E, Walitza, Susanne, Brandeis, Daniel, Glennon, Jeffrey C, Franke, Barbara, Zwiers, Marcel P, and Buitelaar, Jan K

Published
2020
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7. Distinct associations between fronto-striatal glutamate concentrations and callous-unemotional traits and proactive aggression in disruptive behavior

Author

Craig, Michael C., Mulder, Leandra M., Zwiers, Marcel P., Sethi, Arjun, Hoekstra, Pieter J., Dietrich, Andrea, Baumeister, Sarah, Aggensteiner, Pascal M., Banaschewski, Tobias, Brandeis, Daniel, Werhahn, Julia E., Walitza, Susanne, Castro-Fornieles, Josefina, Arango, Celso, Schulze, Ulrike M.E., Glennon, Jeffrey C., Franke, Barbara, Santosh, Paramala J., Mastroianni, Mathilde, van Asten, Jack J.A., Buitelaar, Jan K., Lythgoe, David J., and Naaijen, Jilly

Published
2019
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8. Effect of managed transition on mental health outcomes for young people at the child-adult mental health service boundary:A randomised clinical trial

Author

Singh, S. P., Tuomainen, H., Bouliotis, G., Canaway, A., De Girolamo, G., Dieleman, G. C., Franić, T., Madan, J., Maras, A., McNicholas, F., Paul, M., Purper-Ouakil, D., Santosh, P., Schulze, U. M.E., Street, C., Tremmery, S., Verhulst, F. C., Wells, P., Wolke, D., Warwick, J., Tah, Priya, Griffin, James, Appleton, Rebecca, Heaney, Natalie, Lievesley, Kate, Mastroianni, Mathilde, Singh, Jatinder, Adams, Laura, Signorini, Giulia, Ferrari, Alessandro, Gheza, Elisa, Ferrari, Cecilia, Rivolta, Laura, Levi, Flavia, Cataldo, Maria, Manenti, Lidia, Morini, Giorgia, Pastore, Adriana, Stagni, Pamela, Toselli, Cecilia, Varvara, Pamela, Russet, Frédérick, Maurice, Virginie, Humbertclaude, Véronique, Bodegom, Larissa S.Van, Overbeek, Mathilde M., Gerritsen, Suzanne E., Saam, Melanie, Breuninger, Ulrike, Hendrickx, Gaëlle, Singh, S. P., Tuomainen, H., Bouliotis, G., Canaway, A., De Girolamo, G., Dieleman, G. C., Franić, T., Madan, J., Maras, A., McNicholas, F., Paul, M., Purper-Ouakil, D., Santosh, P., Schulze, U. M.E., Street, C., Tremmery, S., Verhulst, F. C., Wells, P., Wolke, D., Warwick, J., Tah, Priya, Griffin, James, Appleton, Rebecca, Heaney, Natalie, Lievesley, Kate, Mastroianni, Mathilde, Singh, Jatinder, Adams, Laura, Signorini, Giulia, Ferrari, Alessandro, Gheza, Elisa, Ferrari, Cecilia, Rivolta, Laura, Levi, Flavia, Cataldo, Maria, Manenti, Lidia, Morini, Giorgia, Pastore, Adriana, Stagni, Pamela, Toselli, Cecilia, Varvara, Pamela, Russet, Frédérick, Maurice, Virginie, Humbertclaude, Véronique, Bodegom, Larissa S.Van, Overbeek, Mathilde M., Gerritsen, Suzanne E., Saam, Melanie, Breuninger, Ulrike, and Hendrickx, Gaëlle

Abstract

Background Poor transition planning contributes to discontinuity of care at the child-adult mental health service boundary (SB), adversely affecting mental health outcomes in young people (YP). The aim of the study was to determine whether managed transition (MT) improves mental health outcomes of YP reaching the child/adolescent mental health service (CAMHS) boundary compared with usual care (UC). Methods A two-arm cluster-randomised trial (ISRCTN83240263 and NCT03013595) with clusters allocated 1:2 between MT and UC. Recruitment took place in 40 CAMHS (eight European countries) between October 2015 and December 2016.

Published
2023

9. The effects of callous-unemotional traits and aggression subtypes on amygdala activity in response to negative faces – ERRATUM

Author

Aggensteiner, Pascal-M; https://orcid.org/0000-0002-1048-9044, Holz, Nathalie E, Böttinger, Boris W, Baumeister, Sarah, Hohmann, Sarah, Werhahn, Julia E, Naaijen, Jilly, Ilbegi, Shahrzad, Glennon, Jeffrey C, Hoekstra, Pieter J, Dietrich, Andrea, Deters, Renee Kleine, Saam, Melanie C, Schulze, Ulrike M E, Lythgoe, David J, Sethi, Arjun, Craig, Michael C, Mastroianni, Mathilde, Sagar-Ouriaghli, Ilyas, Santosh, Paramala J, Rosa, Mireia, Bargallo, Nuria, Castro-Fornieles, Josefina, Arango, Celso, Penzol, Maria J, Vidal, Jorge, Franke, Barbara, Zwiers, Marcel P, Buitelaar, Jan K, Walitza, Susanne, Banaschewski, Tobias, Brandeis, Daniel, Aggensteiner, Pascal-M; https://orcid.org/0000-0002-1048-9044, Holz, Nathalie E, Böttinger, Boris W, Baumeister, Sarah, Hohmann, Sarah, Werhahn, Julia E, Naaijen, Jilly, Ilbegi, Shahrzad, Glennon, Jeffrey C, Hoekstra, Pieter J, Dietrich, Andrea, Deters, Renee Kleine, Saam, Melanie C, Schulze, Ulrike M E, Lythgoe, David J, Sethi, Arjun, Craig, Michael C, Mastroianni, Mathilde, Sagar-Ouriaghli, Ilyas, Santosh, Paramala J, Rosa, Mireia, Bargallo, Nuria, Castro-Fornieles, Josefina, Arango, Celso, Penzol, Maria J, Vidal, Jorge, Franke, Barbara, Zwiers, Marcel P, Buitelaar, Jan K, Walitza, Susanne, Banaschewski, Tobias, and Brandeis, Daniel

Published
2023

10. Different Whole-Brain Functional Connectivity Correlates of Reactive-Proactive Aggression and Callous-Unemotional Traits in Children and Adolescents with Disruptive Behaviors

Author

Werhahn, Julia E, Smigielski, Lukasz, Sacu, Seda; https://orcid.org/0000-0003-4734-9835, Mohl, Susanna, Willinger, David, Naaijen, Jilly, Mulder, Leandra M, Glennon, Jeffrey C, Hoekstra, Pieter J, Dietrich, Andrea, Deters, Renee Kleine, Aggensteiner, Pascal M, Holz, Nathalie E, Baumeister, Sarah, Banaschewski, Tobias, Saam, Melanie C, Schulze, Ulrike M E, Lythgoe, David J, Sethi, Arjun, Craig, Michael, Mastroianni, Mathilde, Sagar-Ouriaghli, Ilyas, Santosh, Paramala J, Rosa, Mireia, Bargallo, Nuria, Castro-Fornieles, Josefina, Arango, Celso, Penzol, Maria J, Zwiers, Marcel P, Franke, Barbara, Buitelaar, Jan K, Walitza, Susanne; https://orcid.org/0000-0002-8161-8683, Brandeis, Daniel, Werhahn, Julia E, Smigielski, Lukasz, Sacu, Seda; https://orcid.org/0000-0003-4734-9835, Mohl, Susanna, Willinger, David, Naaijen, Jilly, Mulder, Leandra M, Glennon, Jeffrey C, Hoekstra, Pieter J, Dietrich, Andrea, Deters, Renee Kleine, Aggensteiner, Pascal M, Holz, Nathalie E, Baumeister, Sarah, Banaschewski, Tobias, Saam, Melanie C, Schulze, Ulrike M E, Lythgoe, David J, Sethi, Arjun, Craig, Michael, Mastroianni, Mathilde, Sagar-Ouriaghli, Ilyas, Santosh, Paramala J, Rosa, Mireia, Bargallo, Nuria, Castro-Fornieles, Josefina, Arango, Celso, Penzol, Maria J, Zwiers, Marcel P, Franke, Barbara, Buitelaar, Jan K, Walitza, Susanne; https://orcid.org/0000-0002-8161-8683, and Brandeis, Daniel

Abstract

Background: Disruptive behavior in children and adolescents can manifest as reactive aggression and proactive aggression and is modulated by callous-unemotional traits and other comorbidities. Neural correlates of these aggression dimensions or subtypes and comorbid symptoms remain largely unknown. This multi-center study investigated the relationship between resting state functional connectivity (rsFC) and aggression subtypes considering comorbidities. Methods: The large sample of children and adolescents aged 8–18 years (n = 207; mean age = 13.30 ± 2.60 years, 150 males) included 118 cases with disruptive behavior (80 with Oppositional Defiant Disorder and/or Conduct Disorder) and 89 controls. Attention-deficit/hyperactivity disorder (ADHD) and anxiety symptom scores were analyzed as covariates when assessing group differences and dimensional aggression effects on hypothesis-free global and local voxel-to-voxel whole-brain rsFC based on functional magnetic resonance imaging at 3 Tesla. Results: Compared to controls, the cases demonstrated altered rsFC in frontal areas, when anxiety but not ADHD symptoms were controlled. For cases, reactive and proactive aggression scores related to global and local rsFC in the central gyrus and precuneus, regions linked to aggression-related impairments. Callous-unemotional trait severity was correlated with ICC in the inferior and middle temporal regions implicated in empathy, emotion, and reward processing. Most observed aggression subtype-specific patterns could only be identified when ADHD and anxiety were controlled for. Conclusions: This study clarifies that hypothesis-free brain connectivity measures can disentangle distinct though overlapping dimensions of aggression in youths. Moreover, our results highlight the importance of considering comorbid symptoms to detect aggression-related rsFC alterations in youths.

Published
2023

11. Cohort profile

Author

Gerritsen, Suzanne E., Maras, Athanasios, van Bodegom, Larissa S., Overbeek, Mathilde M., Verhulst, Frank C., Wolke, Dieter, Appleton, Rebecca, Bertani, Angelo, Cataldo, Maria G., Conti, Patrizia, Da Fonseca, David, Davidović, Nikolina, Dodig-Ćurković, Katarina, Ferrari, Cecilia, Fiori, Federico, Franić, Tomislav, Gatherer, Charlotte, De Girolamo, Giovanni, Heaney, Natalie, Hendrickx, Gaëlle, Kolozsvari, Alfred, Levi, Flavia Micol, Lievesley, Kate, Madan, Jason, Martinelli, Ottaviano, Mastroianni, Mathilde, Maurice, Virginie, McNicholas, Fiona, O'Hara, Lesley, Paul, Moli, Purper-Ouakil, Diane, de Roeck, Veronique, Russet, Frédérick, Saam, Melanie C., Sagar-Ouriaghli, Ilyas, Santosh, Paramala J., Sartor, Anne, Schandrin, Aurélie, Schulze, Ulrike M. E., Signorini, Giulia, Singh, Swaran P., Singh, Jatinder, Street, Cathy, Tah, Priya, Tanase, Elena, Tremmery, Sabine, Tuffrey, Amanda, Tuomainen, Helena, van Amelsvoort, Therese A. M. J., Wilson, Anna, Walker, Leanne, Dieleman, Gwen C., Adams, Laura, Allibrio, Giovanni, Armando, Marco, Aslan, Sonja, Baccanelli, Nadia, Balaudo, Monica, Bergamo, Fabia, Berriman, Jo, Rethore, Chrystèle Bodier, Bonnet-Brilhault, Frédérique, Boon, Albert, Braamse, Karen, Breuninger, Ulrike, Buttiglione, Maura, Buttle, Sarah, Cammarano, Marco, Canaway, Alastair, Cantini, Fortunata, Cappellari, Cristiano, Carenini, Marta, Carrà, Giuseppe, Charvin, Isabelle, Chianura, Krizia, Coleman, Philippa, Colonna, Annalisa, Conese, Patrizia, Costanzo, Raffaella, Daffern, Claire, Danckaerts, Marina, Giacomo, Andrea de, Dineen, Peter, Ermans, Jean-Pierre, Farmer, Alan, Fegert, Jörg M., Ferrari, Alessandro, Ferrari, Sabrina, Galea, Giuliana, Gatta, Michela, Gheza, Elisa, Goglia, Giacomo, Grandetto, MariaRosa, Griffin, James, Healy, Elaine, Holmes, Keith, Humbertclaude, Véronique, Ingravallo, Nicola, Invernizzi, Roberta, Jardri, Renaud, Keeley, Helen, Kelly, Caoimhe, Killilea, Meghan, Kirwan, James, Klockaerts, Catherine, Kovač, Vlatka, Lida-Pulik, Hélène, Liew, Ashley, Lippens, Christel, Lynch, Fionnuala, Macchi, Francesca, Manenti, Lidia, Margari, Francesco, Margari, Lucia, Martinelli, Paola, McDonald, James, McFadden, Leighton, Menghini, Deny, Migone, Maria, Miller, Sarah, Monzani, Emiliano, Morini, Giorgia, Mutafov, Todor, Nacinovich, Renata, Negrinotti, Cristina, Nelis, Emmanuel, Neri, Francesca, Nikolova, Paulina, Nossa, Marzia, Noterdaeme, Michele, Operto, Francesca, Panaro, Vittoria, Parenti, Aesa, Pastore, Adriana, Pemmaraju, Vinuthna, Pepermans, Ann, Petruzzelli, Maria Giuseppina, Presicci, Anna, Prigent, Catherine, Rinaldi, Francesco, Riva, Erika, Rivolta, Laura, Roekens, Anne, Rogers, Ben, Ronzini, Pablo, Sakar, Vehbi, Salvetti, Selena, Sandhu, Tanveer, Schepker, Renate, Scocco, Paolo, Siviero, Marco, Slowik, Michael, Smyth, Courtney, Spadone, Maria Antonietta, Speranza, Mario, Stagi, Paolo, Stagni, Pamela, Starace, Fabrizio, Stoppa, Patrizia, Tansini, Lucia, Toselli, Cecilia, Trabucchi, Guido, Tubito, Maria, Dam, Arno van, Gutschoven, Hanne Van, West, Dirk van, Vanni, Fabio, Vannicola, Chiara, Varuzza, Cristiana, Varvara, Pamela, Ventura, Patrizia, Vicari, Stefano, Vicini, Stefania, Bentzel, Carolin von, Wells, Philip, Williams, Beata, Zabarella, Marina, Zamboni, Anna, Zanetti, Edda, RS: MHeNs - R2 - Mental Health, Psychiatrie & Neuropsychologie, MUMC+: MA Med Staf Spec Psychiatrie (9), Child and Adolescent Psychiatry / Psychology, Clinical Child and Family Studies, LEARN! - Child rearing, and APH - Mental Health

Subjects
Adult, Internationality, SAMPLE, RJ, child & adolescent psychiatry, ADOLESCENT, Jugendpsychiatrie, Cohort Studies, SDG 3 - Good Health and Well-being, ddc:150, QUALITY-OF-LIFE, Psychiatrische Versorgung, Child psychiatry, Humans, Prospective Studies, SCALE, Demography, Retrospective Studies, Psychiatry, Internationalität, OUTCOMES, DDC 150 / Psychology, Adolescent psychiatry, international health services, General Medicine, WHOQOL-BREF, Europe, Mental Health, Mental health services, CROSS, Adolescent Health Services, EXPERIENCE, Kinderpsychiatrie, adult psychiatry, RA, TRANSITION, RC
Abstract

PurposeThe presence of distinct child and adolescent mental health services (CAMHS) and adult mental health services (AMHS) impacts continuity of mental health treatment for young people. However, we do not know the extent of discontinuity of care in Europe nor the effects of discontinuity on the mental health of young people. Current research is limited, as the majority of existing studies are retrospective, based on small samples or used non-standardised information from medical records. The MILESTONE prospective cohort study aims to examine associations between service use, mental health and other outcomes over 24 months, using information from self, parent and clinician reports.ParticipantsSeven hundred sixty-three young people from 39 CAMHS in 8 European countries, their parents and CAMHS clinicians who completed interviews and online questionnaires and were followed up for 2 years after reaching the upper age limit of the CAMHS they receive treatment at.Findings to dateThis cohort profile describes the baseline characteristics of the MILESTONE cohort. The mental health of young people reaching the upper age limit of their CAMHS varied greatly in type and severity: 32.8% of young people reported clinical levels of self-reported problems and 18.6% were rated to be ‘markedly ill’, ‘severely ill’ or ‘among the most extremely ill’ by their clinician. Fifty-seven per cent of young people reported psychotropic medication use in the previous half year.Future plansAnalysis of longitudinal data from the MILESTONE cohort will be used to assess relationships between the demographic and clinical characteristics of young people reaching the upper age limit of their CAMHS and the type of care the young person uses over the next 2 years, such as whether the young person transitions to AMHS. At 2 years follow-up, the mental health outcomes of young people following different care pathways will be compared.Trial registration numberNCT03013595., publishedVersion

Published
2021
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12. Leaving child and adolescent mental health services in the MILESTONE cohort: a longitudinal cohort study on young people's mental health indicators, care pathways, and outcomes in Europe

Author

Gerritsen, Suzanne E, primary, van Bodegom, Larissa S, additional, Overbeek, Mathilde M, additional, Maras, Athanasios, additional, Verhulst, Frank C, additional, Wolke, Dieter, additional, Rizopoulos, Dimitris, additional, de Girolamo, Giovanni, additional, Franić, Tomislav, additional, Madan, Jason, additional, McNicholas, Fiona, additional, Paul, Moli, additional, Purper-Ouakil, Diane, additional, Santosh, Paramala J, additional, Schulze, Ulrike M E, additional, Singh, Swaran P, additional, Street, Cathy, additional, Tremmery, Sabine, additional, Tuomainen, Helena, additional, Dieleman, Gwendolyn C, additional, Appleton, Rebecca, additional, Davidović, Nikolina, additional, Ferrari, Sabrina, additional, Fiori, Federico, additional, Gatherer, Charlotte, additional, Hendrickx, Gaëlle, additional, Holme, Ingrid, additional, Jardri, Renaud, additional, Kolozsvari, Alfred, additional, Lievesley, Kate, additional, Mastroianni, Mathilde, additional, Maurice, Virginie, additional, Morini, Giorgia, additional, Parenti, Aesa, additional, Russet, Frédérick, additional, Saam, Melanie, additional, Sagar-Ouriaghli, Ilyas, additional, Sartor, Anne, additional, Signorini, Giulia, additional, Singh, Jatinder, additional, Tah, Priya, additional, Tuffrey, Amanda, additional, van Amelsvoort, Therese AMJ, additional, Varvara, Pamela, additional, Vicari, Stefano, additional, Walker, Leanne, additional, Wilson, Anna, additional, and Jerkovic, Helena, additional

Published
2022
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13. Development and Psychometric Properties of the Multi-System Profile of Symptoms Scale in Patients with Rett Syndrome

Author

Singh, Jatinder, primary, Fiori, Federico, additional, Law, Mei Lin, additional, Ahmed, Ruksana, additional, Ameenpur, Shashidhar, additional, Basheer, Salah, additional, Chishti, Samiya, additional, Lawrence, Rosie, additional, Mastroianni, Mathilde, additional, Mosaddegh, Abdolreza, additional, and Santosh, Paramala, additional

Published
2022
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14. The effects of callous-unemotional traits and aggression subtypes on amygdala activity in response to negative faces

Author

Aggensteiner, Pascal-M, Holz, Nathalie E, Böttinger, Boris W, Baumeister, Sarah, Hohmann, Sarah, Werhahn, Julia E, Walitza, Susanne, Brandeis, Daniel, Naaijen, Jilly, Ilbegi, Shahrzad, Glennon, Jeffrey C, Hoekstra, Pieter J, Dietrich, Andrea, Deters, Renee Kleine, Saam, Melanie C, Schulze, Ulrike M E, Lythgoe, David J, Sethi, Arjun, Craig, Michael C, Mastroianni, Mathilde, Sagar-Ouriaghli, Ilyas, Santosh, Paramala J, Rosa, Mireia, Bargallo, Nuria, Castro-Fornieles, Josefina, Arango, Celso, Penzol, Maria J, Vidal, Jorge, Franke, Barbara, Zwiers, Marcel P, Buitelaar, Jan K, Banaschewski, Tobias, University of Zurich, and Aggensteiner, Pascal-M

Subjects
2738 Psychiatry and Mental Health, 610 Medicine & health, 10058 Department of Child and Adolescent Psychiatry, 10064 Neuroscience Center Zurich, 3202 Applied Psychology
Published
2022

15. Effect of managed transition on mental health outcomes for young people at the child–adult mental health service boundary : a randomised clinical trial

Author

Singh, S. P., Tuomainen, H., Bouliotis, G., Canaway, A., De Girolamo, G., Dieleman, G. C., Franić, T., Madan, J., Maras, A., McNicholas, F., Paul, M., Purper-Ouakil, D., Santosh, P., Schulze, U. M.E., Street, C., Tremmery, S., Verhulst, F. C., Wells, P., Wolke, D., Warwick, J., Tah, Priya, Griffin, James, Appleton, Rebecca, Heaney, Natalie, Lievesley, Kate, Mastroianni, Mathilde, Singh, Jatinder, Adams, Laura, Signorini, Giulia, Ferrari, Alessandro, Gheza, Elisa, Ferrari, Cecilia, Rivolta, Laura, Levi, Flavia, Cataldo, Maria, Manenti, Lidia, Morini, Giorgia, Pastore, Adriana, Stagni, Pamela, Toselli, Cecilia, Varvara, Pamela, Russet, Frédérick, Maurice, Virginie, Humbertclaude, Véronique, Bodegom, Larissa S.Van, Overbeek, Mathilde M., Gerritsen, Suzanne E., Saam, Melanie, Breuninger, Ulrike, Hendrickx, Gaëlle, The MILESTONE Consortium, and Child and Adolescent Psychiatry / Psychology

Subjects
Clinical trial, Psychiatry and Mental health, medicine.medical_specialty, SDG 3 - Good Health and Well-being, RJ, medicine, Psychiatry, Psychology, Mental health, Applied Psychology, Boundary (real estate), Mental health service
Abstract

BackgroundPoor transition planning contributes to discontinuity of care at the child–adult mental health service boundary (SB), adversely affecting mental health outcomes in young people (YP). The aim of the study was to determine whether managed transition (MT) improves mental health outcomes of YP reaching the child/adolescent mental health service (CAMHS) boundary compared with usual care (UC).MethodsA two-arm cluster-randomised trial (ISRCTN83240263 and NCT03013595) with clusters allocated 1:2 between MT and UC. Recruitment took place in 40 CAMHS (eight European countries) between October 2015 and December 2016. Eligible participants were CAMHS service users who were receiving treatment or had a diagnosed mental disorder, had an IQ ⩾ 70 and were within 1 year of reaching the SB. MT was a multi-component intervention that included CAMHS training, systematic identification of YP approaching SB, a structured assessment (Transition Readiness and Appropriateness Measure) and sharing of information between CAMHS and adult mental health services. The primary outcome was HoNOSCA (Health of the Nation Outcome Scale for Children and Adolescents) score 15-months post-entry to the trial.ResultsThe mean difference in HoNOSCA scores between the MT and UC arms at 15 months was −1.11 points (95% confidence interval −2.07 to −0.14, p = 0.03). The cost of delivering the intervention was relatively modest (€17–€65 per service user).ConclusionsMT led to improved mental health of YP after the SB but the magnitude of the effect was small. The intervention can be implemented at low cost and form part of planned and purposeful transitional care.

Published
2021

16. Development and Psychometric Properties of a New Questionnaire to Assess Mental Health and Concerning Behaviors in Children and Young People with Autism Spectrum Disorder (ASD):The Assessment of Concerning Behavior (ACB) Scale

Author

Tarver, Joanne, Vitoratou, Silia, Mastroianni, Mathilde, Heaney, Natalie, Bennett, Eleanor, Gibbons, Felicity, Fiori, Federico, Absoud, Michael, Ramasubramanian, Lakshmi, Simonoff, Emily, and Santosh, Paramala

Subjects
education
Abstract

Although 70% of autistic children and young people meet criteria for co-occurring psychiatric conditions, there are few screening measures specifically for autistic individuals. We describe the development and validation of the Assessment of Concerning Behavior (ACB), an instrument co-developed with the autistic community to assess mental health and problematic/risky behaviors. Items include descriptions to facilitate symptom recognition by autistic people, and carers/professionals. The ACB was completed by 255 parents, 149 autistic children and young people and 30 teachers. Internal consistency, stability and validity was assessed. The ACB parent-version fit a two-factor model (internalizing and externalizing problems) and showed adequate test–retest reliability, internal consistency and construct validity. The ACB is a promising new measure for research and clinical use in autism.

Published
2021

17. Cohort profile: demographic and clinical characteristics of the MILESTONE longitudinal cohort of young people approaching the upper age limit of their child mental health care service in Europe

Author

Gerritsen, Suzanne E, primary, Maras, Athanasios, additional, van Bodegom, Larissa S, additional, Overbeek, Mathilde M, additional, Verhulst, Frank C, additional, Wolke, Dieter, additional, Appleton, Rebecca, additional, Bertani, Angelo, additional, Cataldo, Maria G, additional, Conti, Patrizia, additional, Da Fonseca, David, additional, Davidović, Nikolina, additional, Dodig-Ćurković, Katarina, additional, Ferrari, Cecilia, additional, Fiori, Federico, additional, Franić, Tomislav, additional, Gatherer, Charlotte, additional, De Girolamo, Giovanni, additional, Heaney, Natalie, additional, Hendrickx, Gaëlle, additional, Kolozsvari, Alfred, additional, Levi, Flavia Micol, additional, Lievesley, Kate, additional, Madan, Jason, additional, Martinelli, Ottaviano, additional, Mastroianni, Mathilde, additional, Maurice, Virginie, additional, McNicholas, Fiona, additional, O'Hara, Lesley, additional, Paul, Moli, additional, Purper-Ouakil, Diane, additional, de Roeck, Veronique, additional, Russet, Frédérick, additional, Saam, Melanie C, additional, Sagar-Ouriaghli, Ilyas, additional, Santosh, Paramala J, additional, Sartor, Anne, additional, Schandrin, Aurélie, additional, Schulze, Ulrike M E, additional, Signorini, Giulia, additional, Singh, Swaran P, additional, Singh, Jatinder, additional, Street, Cathy, additional, Tah, Priya, additional, Tanase, Elena, additional, Tremmery, Sabine, additional, Tuffrey, Amanda, additional, Tuomainen, Helena, additional, van Amelsvoort, Therese A M J, additional, Wilson, Anna, additional, Walker, Leanne, additional, and Dieleman, Gwen C, additional

Published
2021
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19. Cohort profile:Demographic and clinical characteristics of the MILESTONE longitudinal cohort of young people approaching the upper age limit of their child mental health care service in Europe

Author

Gerritsen, Suzanne E., Maras, Athanasios, Van Bodegom, Larissa S., Overbeek, Mathilde M., Verhulst, Frank C., Wolke, Dieter, Appleton, Rebecca, Bertani, Angelo, Cataldo, Maria G., Conti, Patrizia, Da Fonseca, David, Davidović, Nikolina, Dodig-A †urković, Katarina, Ferrari, Cecilia, Fiori, Federico, Franić, Tomislav, Gatherer, Charlotte, De Girolamo, Giovanni, Heaney, Natalie, Hendrickx, Gaëlle, Kolozsvari, Alfred, Levi, Flavia Micol, Lievesley, Kate, Madan, Jason, Martinelli, Ottaviano, Mastroianni, Mathilde, Maurice, Virginie, McNicholas, Fiona, O'Hara, Lesley, Paul, Moli, Purper-Ouakil, Diane, De Roeck, Veronique, Russet, Frédérick, Saam, Melanie C., Sagar-Ouriaghli, Ilyas, Santosh, Paramala J., Sartor, Anne, Schandrin, Aurélie, Schulze, Ulrike M.E., Signorini, Giulia, Singh, Swaran P., Singh, Jatinder, Street, Cathy, Tah, Priya, Tanase, Elena, Tremmery, Sabine, Tuffrey, Amanda, Tuomainen, Helena, Van Amelsvoort, Therese A.M.J., Wilson, Anna, Walker, Leanne, Dieleman, Gwen C., Gerritsen, Suzanne E., Maras, Athanasios, Van Bodegom, Larissa S., Overbeek, Mathilde M., Verhulst, Frank C., Wolke, Dieter, Appleton, Rebecca, Bertani, Angelo, Cataldo, Maria G., Conti, Patrizia, Da Fonseca, David, Davidović, Nikolina, Dodig-A †urković, Katarina, Ferrari, Cecilia, Fiori, Federico, Franić, Tomislav, Gatherer, Charlotte, De Girolamo, Giovanni, Heaney, Natalie, Hendrickx, Gaëlle, Kolozsvari, Alfred, Levi, Flavia Micol, Lievesley, Kate, Madan, Jason, Martinelli, Ottaviano, Mastroianni, Mathilde, Maurice, Virginie, McNicholas, Fiona, O'Hara, Lesley, Paul, Moli, Purper-Ouakil, Diane, De Roeck, Veronique, Russet, Frédérick, Saam, Melanie C., Sagar-Ouriaghli, Ilyas, Santosh, Paramala J., Sartor, Anne, Schandrin, Aurélie, Schulze, Ulrike M.E., Signorini, Giulia, Singh, Swaran P., Singh, Jatinder, Street, Cathy, Tah, Priya, Tanase, Elena, Tremmery, Sabine, Tuffrey, Amanda, Tuomainen, Helena, Van Amelsvoort, Therese A.M.J., Wilson, Anna, Walker, Leanne, and Dieleman, Gwen C.

Abstract

Purpose The presence of distinct child and adolescent mental health services (CAMHS) and adult mental health services (AMHS) impacts continuity of mental health treatment for young people. However, we do not know the extent of discontinuity of care in Europe nor the effects of discontinuity on the mental health of young people. Current research is limited, as the majority of existing studies are retrospective, based on small samples or used non-standardised information from medical records. The MILESTONE prospective cohort study aims to examine associations between service use, mental health and other outcomes over 24 months, using information from self, parent and clinician reports. Participants Seven hundred sixty-three young people from 39 CAMHS in 8 European countries, their parents and CAMHS clinicians who completed interviews and online questionnaires and were followed up for 2 years after reaching the upper age limit of the CAMHS they receive treatment at. Findings to date This cohort profile describes the baseline characteristics of the MILESTONE cohort. The mental health of young people reaching the upper age limit of their CAMHS varied greatly in type and severity: 32.8% of young people reported clinical levels of self-reported problems and 18.6% were rated to be € markedly ill', € severely ill' or € among the most extremely ill' by their clinician. Fifty-seven per cent of young people reported psychotropic medication use in the previous half year. Future plans Analysis of longitudinal data from the MILESTONE cohort will be used to assess relationships between the demographic and clinical characteristics of young people reaching the upper age limit of their CAMHS and the type of care the young person uses over the next 2 years, such as whether the young person transitions to AMHS. At 2 years follow-up, the mental health outcomes of young people following different care pathways will be compared. Trial registration number NCT03013595.

Published
2021

20. Aggression subtypes relate to distinct resting state functional connectivity in children and adolescents with disruptive behavior

Author

Werhahn, Julia E; https://orcid.org/0000-0003-2837-1674, Mohl, Susanna, Willinger, David, Smigielski, Lukasz, Roth, Alexander, Hofstetter, Christoph, Stämpfli, Philipp, Naaijen, Jilly, Mulder, Leandra M, Glennon, Jeffrey C, Hoekstra, Pieter J, Dietrich, Andrea, Kleine Deters, Renee, Aggensteiner, Pascal M, Holz, Nathalie E, Baumeister, Sarah, Banaschewski, Tobias, Saam, Melanie C, Schulze, Ulrike M E, Lythgoe, David J, Sethi, Arjun, Craig, Michael C, Mastroianni, Mathilde, Sagar-Ouriaghli, Ilyas, Santosh, Paramala J, Rosa, Mireia, Bargallo, Nuria, Castro-Fornieles, Josefina, Arango, Celso, Penzol, Maria J, Zwiers, Marcel P, Franke, Barbara, Buitelaar, Jan K, Walitza, Susanne; https://orcid.org/0000-0002-8161-8683, Brandeis, Daniel, Werhahn, Julia E; https://orcid.org/0000-0003-2837-1674, Mohl, Susanna, Willinger, David, Smigielski, Lukasz, Roth, Alexander, Hofstetter, Christoph, Stämpfli, Philipp, Naaijen, Jilly, Mulder, Leandra M, Glennon, Jeffrey C, Hoekstra, Pieter J, Dietrich, Andrea, Kleine Deters, Renee, Aggensteiner, Pascal M, Holz, Nathalie E, Baumeister, Sarah, Banaschewski, Tobias, Saam, Melanie C, Schulze, Ulrike M E, Lythgoe, David J, Sethi, Arjun, Craig, Michael C, Mastroianni, Mathilde, Sagar-Ouriaghli, Ilyas, Santosh, Paramala J, Rosa, Mireia, Bargallo, Nuria, Castro-Fornieles, Josefina, Arango, Celso, Penzol, Maria J, Zwiers, Marcel P, Franke, Barbara, Buitelaar, Jan K, Walitza, Susanne; https://orcid.org/0000-0002-8161-8683, and Brandeis, Daniel

Abstract

There is increasing evidence for altered brain resting state functional connectivity in adolescents with disruptive behavior. While a considerable body of behavioral research points to differences between reactive and proactive aggression, it remains unknown whether these two subtypes have dissociable effects on connectivity. Additionally, callous-unemotional traits are important specifiers in subtyping aggressive behavior along the affective dimension. Accordingly, we examined associations between two aggression subtypes along with callous-unemotional traits using a seed-to-voxel approach. Six functionally relevant seeds were selected to probe the salience and the default mode network, based on their presumed role in aggression. The resting state sequence was acquired from 207 children and adolescents of both sexes [mean age (standard deviation) = 13.30 (2.60); range = 8.02-18.35] as part of a Europe-based multi-center study. One hundred eighteen individuals exhibiting disruptive behavior (conduct disorder/oppositional defiant disorder) with varying comorbid attention-deficit/hyperactivity disorder (ADHD) symptoms were studied, together with 89 healthy controls. Proactive aggression was associated with increased left amygdala-precuneus coupling, while reactive aggression related to hyper-connectivities of the posterior cingulate cortex (PCC) to the parahippocampus, the left amygdala to the precuneus and to hypo-connectivity between the right anterior insula and the nucleus caudate. Callous-unemotional traits were linked to distinct hyper-connectivities to frontal, parietal, and cingulate areas. Additionally, compared to controls, cases demonstrated reduced connectivity of the PCC and left anterior insula to left frontal areas, the latter only when controlling for ADHD scores. Taken together, this study revealed aggression-subtype-specific patterns involving areas associated with emotion, empathy, morality, and cognitive control.

Published
2021

21. Transition as a topic in psychiatry training throughout Europe: trainees' perspectives

Author

Hendrickx, Gaelle, De Roeck, Veronique, Russet, Frederick, Dieleman, Gwen, Franic, Tomislav, Maras, Athanasios, McNicholas, Fiona, Paul, Moli, Santosh, Paramala, Schulze, Ulrike, Signorini, Giulia, Singh, Swaran P, Street, Cathy, Tuomainen, Helena, Verhulst, Frank, Wolke, Dieter, Purper-Ouakil, Diane, Tremmery, Sabine, Singh, Swaran, Madan, Jason, Warwick, Jane, Tah, Priya, Appleton, Rebecca, Canaway, Alastair, Griffin, James, Wells, Philip, Lomax, Rose-Marie, de Girolamo, Giovanni, Heaney, Natalie, Mastroianni, Mathilde, Fiori, Federico, Maurice, Virginie, Humbertclaude, Veronique, van Bodegom, Larissa, Overbeek, Mathilde, Saam, Melanie, Breuninger, Ulrike, Sartor, Anne, Tanase, Elena, Gronostaj, Aleksandra, Holme, Ingrid, Davidovic, Nikolina, Gerritsen, Suzanne, Lievesley, Kate, Tuffrey, Amanda, Wilson, Anna, Gatherer, Charlotte, Walker, Leanne, Wohner, Andrea, Child and Adolescent Psychiatry / Psychology, Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Department of Child and Adolescent Psychiatry, University Hospitals Leuven [Leuven], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Erasmus University Medical Center [Rotterdam] (Erasmus MC), University of Split, Yulius Academy, University College Dublin [Dublin] (UCD), The Geary Institute, Our Lady's Hospital for Sick Children, Warwick Medical School, University of Warwick [Coventry], University Hospital Coventry Warwickshire (UHCW), University Hospital Coventry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, King‘s College London, Universitätsklinikum Ulm - University Hospital of Ulm, and Saint John of God Clinical Research Centre

Subjects
Male, medicine.medical_specialty, MESH: Psychiatry, RJ, Europe, Psychiatry, Trainee, Training, Transition, education, Training (civil), Mental health service, Child and adolescent, 03 medical and health sciences, 0302 clinical medicine, Surveys and Questionnaires, Developmental and Educational Psychology, medicine, Milestone (project management), Child and adolescent psychiatry, Humans, 0501 psychology and cognitive sciences, MESH: Surveys and Questionnaires, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, MESH: Humans, Transition (fiction), 05 social sciences, digestive, oral, and skin physiology, General Medicine, Mental health, MESH: Male, 030227 psychiatry, 3. Good health, Psychiatry and Mental health, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Pediatrics, Perinatology and Child Health, Female, Continuity of care, MESH: Europe, Psychology, MESH: Female, 050104 developmental & child psychology
Abstract

The majority of adolescents with mental health problems do not experience continuity of care when they reach the transition boundary of their child and adolescent mental health service. One of the obstacles for a smooth transition to adult mental health services concerns the lack of training for health-care professionals involved in the transition process. This study aims to seek psychiatric trainees' opinions regarding training on transition and the knowledge and skills required for managing transition. A survey was distributed to trainees residing in European countries. Trainees from 36 countries completed the questionnaire, of which 63% reported that they came into contact with youth and young adults (16-26 years) during their clinical practice. Twenty-seven percent of trainees stated they have good to very good knowledge about the transition process. Theoretical training about transition was reported in only 17% of the countries, and practical training in 28% of the countries. Ninety-four percent of trainees indicated that further training about transition is necessary. The content of subsequent transition-related training can be guided by the findings of the MILESTONE project. ispartof: EUROPEAN CHILD & ADOLESCENT PSYCHIATRY vol:29 issue:1 pages:41-49 ispartof: location:Germany status: published

Published
2020
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22. Assessment of Concerning Behavior

Author

Tarver, Joanne, primary, Vitoratou, Silia, additional, Mastroianni, Mathilde, additional, Heaney, Natalie, additional, Bennett, Eleanor, additional, Gibbons, Felicity, additional, Fiori, Federico, additional, Absoud, Michael, additional, Ramasubramanian, Lakshmi, additional, Simonoff, Emily, additional, and Santosh, Paramala, additional

Published
2021
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23. Development and Psychometric Properties of a New Questionnaire to Assess Mental Health and Concerning Behaviors in Children and Young People with Autism Spectrum Disorder (ASD): The Assessment of Concerning Behavior (ACB) Scale

Author

Tarver, Joanne, primary, Vitoratou, Silia, additional, Mastroianni, Mathilde, additional, Heaney, Natalie, additional, Bennett, Eleanor, additional, Gibbons, Felicity, additional, Fiori, Federico, additional, Absoud, Michael, additional, Ramasubramanian, Lakshmi, additional, Simonoff, Emily, additional, and Santosh, Paramala, additional

Published
2020
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24. The effects of callous-unemotional traits and aggression subtypes on amygdala activity in response to negative faces – ERRATUM

Author

Aggensteiner, Pascal-M, primary, Holz, Nathalie E., additional, Böttinger, Boris W., additional, Baumeister, Sarah, additional, Hohmann, Sarah, additional, Werhahn, Julia E., additional, Naaijen, Jilly, additional, Ilbegi, Shahrzad, additional, Glennon, Jeffrey C., additional, Hoekstra, Pieter J., additional, Dietrich, Andrea, additional, Deters, Renee Kleine, additional, Saam, Melanie C., additional, Schulze, Ulrike M. E., additional, Lythgoe, David J., additional, Sethi, Arjun, additional, Craig, Michael C., additional, Mastroianni, Mathilde, additional, Sagar-Ouriaghli, Ilyas, additional, Santosh, Paramala J., additional, Rosa, Mireia, additional, Bargallo, Nuria, additional, Castro-Fornieles, Josefina, additional, Arango, Celso, additional, Penzol, Maria J., additional, Vidal, Jorge, additional, Franke, Barbara, additional, Zwiers, Marcel P., additional, Buitelaar, Jan K., additional, Walitza, Susanne, additional, Banaschewski, Tobias, additional, and Brandeis, Daniel, additional

Published
2020
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25. Aggression subtypes relate to distinct resting state functional connectivity in children and adolescents with disruptive behavior

Author

Werhahn, Julia E., primary, Mohl, Susanna, additional, Willinger, David, additional, Smigielski, Lukasz, additional, Roth, Alexander, additional, Hofstetter, Christoph, additional, Stämpfli, Philipp, additional, Naaijen, Jilly, additional, Mulder, Leandra M., additional, Glennon, Jeffrey C., additional, Hoekstra, Pieter J., additional, Dietrich, Andrea, additional, Kleine Deters, Renee, additional, Aggensteiner, Pascal M., additional, Holz, Nathalie E., additional, Baumeister, Sarah, additional, Banaschewski, Tobias, additional, Saam, Melanie C., additional, Schulze, Ulrike M. E., additional, Lythgoe, David J., additional, Sethi, Arjun, additional, Craig, Michael C., additional, Mastroianni, Mathilde, additional, Sagar-Ouriaghli, Ilyas, additional, Santosh, Paramala J., additional, Rosa, Mireia, additional, Bargallo, Nuria, additional, Castro-Fornieles, Josefina, additional, Arango, Celso, additional, Penzol, Maria J., additional, Zwiers, Marcel P., additional, Franke, Barbara, additional, Buitelaar, Jan K., additional, Walitza, Susanne, additional, and Brandeis, Daniel, additional

Published
2020
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26. Validation of the Transition Readiness and Appropriateness Measure (TRAM) for the Managing the Link and Strengthening Transition from Child to Adult Mental Healthcare in Europe (MILESTONE) study

Author

Santosh, Paramala, primary, Singh, Jatinder, additional, Adams, Laura, additional, Mastroianni, Mathilde, additional, Heaney, Natalie, additional, Lievesley, Kate, additional, Sagar-Ouriaghli, Ilyas, additional, Allibrio, Giovanni, additional, Appleton, Rebecca, additional, Davidović, Nikolina, additional, de Girolamo, Giovanni, additional, Dieleman, Gwen, additional, Dodig-Ćurković, Katarina, additional, Franić, Tomislav, additional, Gatherer, Charlotte, additional, Gerritsen, Suzanne, additional, Gheza, Elisa, additional, Madan, Jason, additional, Manenti, Lidia, additional, Maras, Athanasios, additional, Margari, Francesco, additional, McNicholas, Fiona, additional, Pastore, Adriana, additional, Paul, Moli, additional, Purper-Ouakil, Diane, additional, Rinaldi, Francesco, additional, Sakar, Vehbi, additional, Schulze, Ulrike, additional, Signorini, Giulia, additional, Street, Cathy, additional, Tah, Priya, additional, Tremmery, Sabine, additional, Tuffrey, Amanda, additional, Tuomainen, Helena, additional, Verhulst, Frank, additional, Warwick, Jane, additional, Wilson, Anna, additional, Wolke, Dieter, additional, Fiori, Federico, additional, and Singh, Swaran, additional

Published
2020
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27. Different Whole-Brain Functional Connectivity Correlates of Reactive-Proactive Aggression and Callous-Unemotional Traits in Disruptive Children and Adolescents

Author

Werhahn, Julia E, primary, Mohl, Susanna, additional, Willinger, David, additional, Smigielski, Lukasz, additional, Roth, Alexander, additional, Naaijen, Jilly, additional, Mulder, Leandra M, additional, Glennon, Jeffrey C, additional, Hoekstra, Pieter J, additional, Dietrich, Andrea, additional, Deters, Renee Kleine, additional, Aggensteiner, Pascal M, additional, Holz, Nathalie E, additional, Baumeister, Sarah, additional, Banaschewski, Tobias, additional, Saam, Melanie C, additional, Schulze, Ulrike M E, additional, Lythgoe, David J, additional, Sethi, Arjun, additional, Craig, Michael, additional, Mastroianni, Mathilde, additional, Sagar-Ouriaghli, Ilyas, additional, Santosh, Paramala J, additional, Rosa, Mireia, additional, Bargallo, Nuria, additional, Castro-Fornieles, Josefina, additional, Arango, Celso, additional, Penzol, Maria J, additional, Zwiers, Marcel P, additional, Franke, Barbara, additional, Buitelaar, Jan K, additional, Walitza, Susanne, additional, and Brandeis, Daniel, additional

Published
2019
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28. Reactive/proactive aggression specific cortical and subcortical alterations in children and adolescents with disruptive behavior

Author

Naaijen, Jilly, primary, Mulder, Leandra M, additional, Ilbegi, Shahrzad, additional, Bruijn, Sanne de, additional, Kleine-Deters, Renee, additional, Dietrich, Andrea, additional, Hoekstra, Pieter J, additional, Marsman, Jan-Bernard C, additional, Aggensteiner, Pascal M, additional, Holz, Nathalie E, additional, Boettinger, Boris, additional, Baumeister, Sarah, additional, Banaschewski, Tobias, additional, Saam, Melanie C, additional, Schulze, Ulrike M E, additional, Santosh, Paramala J, additional, Sagar-Ouriaghli, Ilyas, additional, Mastroianni, Mathilde, additional, Fornieles, Josefina Castro, additional, Bargallo, Nuria, additional, Rosa, Mireia, additional, Arango, Celso, additional, Penzol, Maria J, additional, Werhahn, Julia E, additional, Walitza, Susanne, additional, Brandeis, Daniel, additional, Glennon, Jeffrey C, additional, Franke, Barbara, additional, Zwiers, Marcel P, additional, and Buitelaar, Jan K, additional

Published
2018
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29. Aggression Subtypes Relate to Distinct Resting State Functional Connectivity in Disruptive Children and Adolescents

Author

Werhahn, Julia E, primary, Mohl, Susanna, additional, Willinger, David, additional, Smigielski, Lukasz, additional, Roth, Alexander, additional, Hofstetter, Christoph, additional, Stämpfli, Philipp, additional, Häberling, Isabelle, additional, Naaijen, Jilly, additional, Mulder, Leandra M, additional, Glennon, Jeffrey C, additional, Hoekstra, Pieter J, additional, Dietrich, Andrea, additional, Deters, Renee Kleine, additional, Aggensteiner, Pascal M, additional, Holz, Nathalie E, additional, Baumeister, Sarah, additional, Banaschewski, Tobias, additional, Saam, Melanie C, additional, Schulze, Ulrike M E, additional, Lythgoe, David J, additional, Sethi, Arjun, additional, Craig, Michael, additional, Mastroianni, Mathilde, additional, Sagar-Ouriaghli, Ilyas, additional, Santosh, Paramala J, additional, Rosa, Mireia, additional, Bargallo, Nuria, additional, Castro-Fornieles, Josefina, additional, Aragno, Celso, additional, Penzol, Maria J, additional, Franke, Barbara, additional, Zwiers, Marcel P, additional, Buitelaar, Jan K, additional, Walitza, Susanne, additional, and Brandeis, Daniel, additional

Published
2018
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30. The effects of callous-unemotional traits and aggression subtypes on amygdala activity in response to negative faces – ERRATUM.

Author

Aggensteiner, Pascal-M, Holz, Nathalie E., Böttinger, Boris W., Baumeister, Sarah, Hohmann, Sarah, Werhahn, Julia E., Naaijen, Jilly, Ilbegi, Shahrzad, Glennon, Jeffrey C., Hoekstra, Pieter J., Dietrich, Andrea, Deters, Renee Kleine, Saam, Melanie C., Schulze, Ulrike M. E., Lythgoe, David J., Sethi, Arjun, Craig, Michael C., Mastroianni, Mathilde, Sagar-Ouriaghli, Ilyas, and Santosh, Paramala J.

Subjects
BEHAVIOR disorders, BEHAVIOR disorders in children, EMOTIONS, AMYGDALOID body, ANTISOCIAL personality disorders
Abstract

A correction is presented to the article "effects of callous-unemotional traits and aggression subtypes on amygdala activity in response to negative faces."

Published
2023
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31. The effects of callous-unemotional traits and aggression subtypes on amygdala activity in response to negative faces.

Author

Aggensteiner PM, Holz NE, Böttinger BW, Baumeister S, Hohmann S, Werhahn JE, Naaijen J, Ilbegi S, Glennon JC, Hoekstra PJ, Dietrich A, Deters RK, Saam MC, Schulze UME, Lythgoe DJ, Sethi A, Craig MC, Mastroianni M, Sagar-Ouriaghli I, Santosh PJ, Rosa M, Bargallo N, Castro-Fornieles J, Arango C, Penzol MJ, Vidal J, Franke B, Zwiers MP, Buitelaar JK, Walitza S, Banaschewski T, and Brandeis D

Subjects
Adolescent, Aggression psychology, Amygdala diagnostic imaging, Attention Deficit and Disruptive Behavior Disorders, Child, Emotions physiology, Humans, Conduct Disorder, Problem Behavior
Abstract

Background: Brain imaging studies have shown altered amygdala activity during emotion processing in children and adolescents with oppositional defiant disorder (ODD) and conduct disorder (CD) compared to typically developing children and adolescents (TD). Here we aimed to assess whether aggression-related subtypes (reactive and proactive aggression) and callous-unemotional (CU) traits predicted variation in amygdala activity and skin conductance (SC) response during emotion processing., Methods: We included 177 participants (n = 108 cases with disruptive behaviour and/or ODD/CD and n = 69 TD), aged 8-18 years, across nine sites in Europe, as part of the EU Aggressotype and MATRICS projects. All participants performed an emotional face-matching functional magnetic resonance imaging task., Results: Differences between cases and TD in affective processing, as well as specificity of activation patterns for aggression subtypes and CU traits, were assessed. Simultaneous SC recordings were acquired in a subsample (n = 63). Cases compared to TDs showed higher amygdala activity in response to negative faces (fearful and angry) v. shapes. Subtyping cases according to aggression-related subtypes did not significantly influence on amygdala activity; while stratification based on CU traits was more sensitive and revealed decreased amygdala activity in the high CU group. SC responses were significantly lower in cases and negatively correlated with CU traits, reactive and proactive aggression., Conclusions: Our results showed differences in amygdala activity and SC responses to emotional faces between cases with ODD/CD and TD, while CU traits moderate both central (amygdala) and peripheral (SC) responses. Our insights regarding subtypes and trait-specific aggression could be used for improved diagnostics and personalized treatment.

Published
2022
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