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197 results on '"Masuda, Tatsuya"'

1. Polarity of homoepitaxial ZnO films grown by Nd:YAG pulsed laser deposition.

Author

Masuda, Tatsuya, Sato, Toshihiro, Lippmaa, Mikk, Dazai, Takuro, Sekine, Norihiko, Hosako, Iwao, Koinuma, Hideomi, and Takahashi, Ryota

Subjects
*ZINC oxide films, *PULSED laser deposition, *ND-YAG lasers, *ION scattering, *SUBSTRATES (Materials science), *YTTRIUM aluminum garnet
Abstract

We investigate the stability of the polar surface of ZnO films grown homoepitaxially on atomically flat ZnO (000 1 ¯) O-face substrates by neodymium yttrium aluminum garnet (Nd:YAG) pulsed laser deposition (PLD). For films grown in the temperature range from 500 to 700 °C, ion scattering spectroscopy showed that the film surface termination was the same as the ZnO substrate. Even for a Mg0.2Zn0.8O/ZnO superlattice, no polarity reversal occurred, indicating that the ZnO (000 1 ¯) O-face is highly stable, despite the film surface sputtering caused by the high kinetic energy of the PLD plume generated by the Nd:YAG laser. [ABSTRACT FROM AUTHOR]

Published
2024
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6. RUNX1–Survivin Axis Is a Novel Therapeutic Target for Malignant Rhabdoid Tumors

Author

Mikami, Masamitsu, primary, Masuda, Tatsuya, additional, Kanatani, Takuya, additional, Noura, Mina, additional, Umeda, Katsutsugu, additional, Hiramatsu, Hidefumi, additional, Kubota, Hirohito, additional, Daifu, Tomoo, additional, Iwai, Atsushi, additional, Hattori, Etsuko Yamamoto, additional, Furuichi, Kana, additional, Takasaki, Saho, additional, Tanaka, Sunao, additional, Matsui, Yasuzumi, additional, Matsuo, Hidemasa, additional, Hirata, Masahiro, additional, Kataoka, Tatsuki R., additional, Nakahata, Tatsutoshi, additional, Kuwahara, Yasumichi, additional, Iehara, Tomoko, additional, Hosoi, Hajime, additional, Imai, Yoichi, additional, Takita, Junko, additional, Sugiyama, Hiroshi, additional, Adachi, Souichi, additional, and Kamikubo, Yasuhiko, additional

Published
2022
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10. RUNX1 transactivates BCR‐ABL1 expression in Philadelphia chromosome positive acute lymphoblastic leukemia

Author

Masuda, Tatsuya, primary, Maeda, Shintaro, additional, Shimada, Sae, additional, Sakuramoto, Naoya, additional, Morita, Ken, additional, Koyama, Asami, additional, Suzuki, Kensho, additional, Mitsuda, Yoshihide, additional, Matsuo, Hidemasa, additional, Kubota, Hirohito, additional, Kato, Itaru, additional, Tanaka, Kuniaki, additional, Takita, Junko, additional, Hirata, Masahiro, additional, Kataoka, Tatsuki R, additional, Nakahata, Tatsutoshi, additional, Adachi, Souichi, additional, Hirai, Hideyo, additional, Mizuta, Shuichi, additional, Naka, Kazuhito, additional, Imai, Yoichi, additional, Kimura, Shinya, additional, Sugiyama, Hiroshi, additional, and Kamikubo, Yasuhiko, additional

Published
2021
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11. RUNX inhibitor suppresses graft‐versus‐host disease through targeting RUNX‐NFATC2 axis

Author

Kubota, Hirohito, primary, Masuda, Tatsuya, additional, Noura, Mina, additional, Furuichi, Kana, additional, Matsuo, Hidemasa, additional, Hirata, Masahiro, additional, Kataoka, Tatsuki R., additional, Hiramatsu, Hidefumi, additional, Yasumi, Takahiro, additional, Nakahata, Tatsutoshi, additional, Imai, Yoichi, additional, Takita, Junko, additional, Adachi, Souichi, additional, Sugiyama, Hiroshi, additional, and Kamikubo, Yasuhiko, additional

Published
2021
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12. Suppression of malignant rhabdoid tumors through Chb‐M′‐mediated RUNX1 inhibition

Author

Daifu, Tomoo, primary, Mikami, Masamitsu, additional, Hiramatsu, Hidefumi, additional, Iwai, Atsushi, additional, Umeda, Katsutsugu, additional, Noura, Mina, additional, Kubota, Hirohito, additional, Masuda, Tatsuya, additional, Furuichi, Kana, additional, Takasaki, Saho, additional, Noguchi, Yuki, additional, Morita, Ken, additional, Bando, Toshikazu, additional, Hirata, Masahiro, additional, Kataoka, Tatsuki R., additional, Nakahata, Tatsutoshi, additional, Kuwahara, Yasumichi, additional, Iehara, Tomoko, additional, Hosoi, Hajime, additional, Takita, Junko, additional, Sugiyama, Hiroshi, additional, Adachi, Souichi, additional, and Kamikubo, Yasuhiko, additional

Published
2020
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13. RUNX-NFAT Axis As a Novel Therapeutic Target for AML and T Cell Immunity

Author

Masuda, Tatsuya, primary, Kubota, Hirohito, additional, Sakuramoto, Naoya, additional, Hada, Asuka, additional, Horiuchi, Ayaka, additional, Sasaki, Asami, additional, Takeda, Kanako, additional, Takeda, Mizuho, additional, Matsuo, Hidemasa, additional, Sugiyama, Hiroshi, additional, Adachi, Souichi, additional, and Kamikubo, Yasuhiko, additional

Published
2020
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14. RUNX1 transactivates BCR‐ABL1 expression in Philadelphia chromosome positive acute lymphoblastic leukemia.

Author

Masuda, Tatsuya, Maeda, Shintaro, Shimada, Sae, Sakuramoto, Naoya, Morita, Ken, Koyama, Asami, Suzuki, Kensho, Mitsuda, Yoshihide, Matsuo, Hidemasa, Kubota, Hirohito, Kato, Itaru, Tanaka, Kuniaki, Takita, Junko, Hirata, Masahiro, Kataoka, Tatsuki R, Nakahata, Tatsutoshi, Adachi, Souichi, Hirai, Hideyo, Mizuta, Shuichi, and Naka, Kazuhito

Abstract

The emergence of tyrosine kinase inhibitors as part of a front‐line treatment has greatly improved the clinical outcome of the patients with Ph+ acute lymphoblastic leukemia (ALL). However, a portion of them still become refractory to the therapy mainly through acquiring mutations in the BCR‐ABL1 gene, necessitating a novel strategy to treat tyrosine kinase inhibitor (TKI)‐resistant Ph+ ALL cases. In this report, we show evidence that RUNX1 transcription factor stringently controls the expression of BCR‐ABL1, which can strategically be targeted by our novel RUNX inhibitor, Chb‐M'. Through a series of in vitro experiments, we identified that RUNX1 binds to the promoter of BCR and directly transactivates BCR‐ABL1 expression in Ph+ ALL cell lines. These cells showed significantly reduced expression of BCR‐ABL1 with suppressed proliferation upon RUNX1 knockdown. Moreover, treatment with Chb‐M' consistently downregulated the expression of BCR‐ABL1 in these cells and this drug was highly effective even in an imatinib‐resistant Ph+ ALL cell line. In good agreement with these findings, forced expression of BCR‐ABL1 in these cells conferred relative resistance to Chb‐M'. In addition, in vivo experiments with the Ph+ ALL patient‐derived xenograft cells showed similar results. In summary, targeting RUNX1 therapeutically in Ph+ ALL cells may lead to overcoming TKI resistance through the transcriptional regulation of BCR‐ABL1. Chb‐M' could be a novel drug for patients with TKI‐resistant refractory Ph+ ALL. [ABSTRACT FROM AUTHOR]

Published
2022
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18. Investigation of Carrot Reduction Effect on 4H-Silicon Carbide Epitaxial Wafers with Optimized Buffer Layer

Author

Daisuke Muto, Masuda Tatsuya, Kenji Momose, Y. Mabuchi, and Hiroshi Osawa

Subjects
010302 applied physics, Materials science, Yield (engineering), business.industry, Mechanical Engineering, 02 engineering and technology, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Epitaxy, 01 natural sciences, Buffer (optical fiber), Carbide, chemistry.chemical_compound, chemistry, Mechanics of Materials, 0103 physical sciences, MOSFET, Electronic engineering, Silicon carbide, Optoelectronics, General Materials Science, Wafer, 0210 nano-technology, business, Layer (electronics)
Abstract

We investigated the carrot-defect reduction effect by optimizing the buffer layers of 4H-Silion Carbide (SiC) epitaxial wafers. The SiC epitaxial wafer with the 0.5 μm-thick optimized condition-B buffer layer show the carrot-defect density of 0.13 cm-2, since that with the conventional-A buffer layer were 0.68 cm-2. Although the average bunching length with the optimized condition-B buffer layer was 7-times longer than those with the conventional condition-A buffer layer, we could reduce the bunching length by applying the optimized condition-B only to the initial 0.05 μm-thick buffer layer. Finally, with the initial 0.05 μm-thick optimized condition-B buffer layers, we could achieve the SiC epitaxial wafers with only half the carrot-defect densities of those with the conventional condition-A buffer layers, while the average bunching lengths were less than 100 μm. With this condition, we could achieve the estimated yield of 90.1% with 4 x 4 mm chips, while that with the conventional condition-A buffer layer was 81.9%.

Published
2017

19. Improvement on 150 mm 4H-SiC Epitaxial Wafer Quality

Author

Hitoshi Osawa, Akira Miyasaka, Kenji Momose, Jun Norimatsu, Daisuke Muto, Yutaka Tajima, and Masuda Tatsuya

Subjects
010302 applied physics, Engineering drawing, Materials science, business.industry, Mechanical Engineering, 02 engineering and technology, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Epitaxy, 01 natural sciences, Smooth surface, Quality (physics), Mechanics of Materials, 0103 physical sciences, Optoelectronics, General Materials Science, Wafer, 0210 nano-technology, business, Layer (electronics)
Abstract

For the popularization of SiC power device, improvement on both productivity and quality of 150 mm diameter SiC epitaxial wafer is inevitable. With highly productive 8x150-mm CVD reactor, we have grown epitaxial layer on 4° off 4H-SiC wafer Si-and C-face. Modifying some reactor parts and optimizing growth conditions enabled us to achieve a good balance between high uniformity and smooth surface.

Published
2016

25. Study on Mechanisms of Environmental Change in an Artificial Tidal Flat

Author

Morimoto, Kentaro, Takikawa, Kiyoshi, Tanaka, Kenji, and Masuda, Tatsuya

Subjects
Field Observation, Environmental Change, Artificial Tidal Flat, Ecosystem
Abstract

The Ariake Sea, a typical closed bay on the west coast of Kyushu Island, has suffered from several external impacts. However, the relative contribution of the various factors and processes is still unclear. In this study, field observations were conducted inside the artificial tidal flat to model the physical, chemical and ecological attributes of the tidal flat system for the preservation and recovery of the coastal environment in the Ariake Sea. The communities and environment within the artificial tidal flat pond became established within one year of the artificial pond being completed. Meteorological and tidal conditions were found to strongly affect the topography of the pond, particularly the region between the sub-tidal zone to the supra littoral zone, the development of which itself resulted in stabilization of the tidal flat habitat within the pond.

Published
2005

34. Androgen Receptor Silences Thioredoxin‐interacting Protein and Competitively Inhibits Glucocorticoid Receptor‐Mediated Apoptosis in Pancreatic β‐Cells

Author

Harada, Naoki, primary, Katsuki, Takahiro, additional, Takahashi, Yuji, additional, Masuda, Tatsuya, additional, Yoshinaga, Mariko, additional, Adachi, Tetsuya, additional, Izawa, Takeshi, additional, Kuwamura, Mitsuru, additional, Nakano, Yoshihisa, additional, Yamaji, Ryoichi, additional, and Inui, Hiroshi, additional

Published
2015
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41. Study on Rehabilitation Technology and Evaluation Method at the Tidal Flat in Ariake Bay

Author

Masuda, Tatsuya

Subjects
人工巣穴, 耕転, 377.5, ハビタット, なぎさ線, 熊本港, 野鳥の池
Abstract

本研究では、有明海を豊饒の海として再生するために、様々考えられている環境悪化要因のなかから、海岸線付近に位置する沿岸干潟域における底質環境の悪化と自然の浄化作用を有する干潟や塩性湿地の喪失という2つの要因に着目し、有明海の沿岸干潟環境の現況を調べるとともに、その改善･再生技術の開発と実証試験及び再生策の事業化に向けた評価手法の検討までを幅広く行なった。

Published
2009

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