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3. Secretome-Based Identification and Characterization of Potential Biomarkers in Thyroid Cancer

Author

Kashat, Lawrence, So, Anthony K.-C., Masui, Olena, Wang, X. Simon, Cao, Jun, Meng, Xianwang, MacMillan, Christina, Ailles, Laurie E., Siu, K. W. Michael, Ralhan, Ranju, and Walfish, Paul G.

Abstract

In search of thyroid cancer biomarkers, proteins secreted by thyroid cancer cell lines, papillary-derived TPC-1 and anaplastic-derived CAL62, were analyzed using liquid chromatography−tandem mass spectrometry. Of 46 high-confidence identifications, 6 proteins were considered for verification in thyroid cancer patients’ tissue and blood. The localization of two proteins, nucleolin and prothymosin-α (PTMA), was confirmed in TPC-1 and CAL62 cells by confocal microscopy and immunohistochemically in xenografts of TPC-1 cells in NOD/SCID/γ mice and human thyroid cancers (48 tissues). Increased nuclear and cytoplasmic expression of PTMA was observed in anaplastic compared to papillary and poorly differentiated carcinomas. Nuclear expression of nucleolin was observed in all subtypes of thyroid carcinomas, along with faint cytoplasmic expression in anaplastic cancers. Importantly, PTMA, nucleolin, clusterin, cysteine-rich angiogenic inducer 61, enolase 1, and biotinidase were detected in thyroid cancer patients’ sera, warranting future analysis to confirm their potential as blood-based thyroid cancer markers. In conclusion, we demonstrated the potential of secretome analysis of thyroid cancer cell lines to identify novel proteins that can be independently verified in cell lines, xenografts, tumor tissues, and blood samples of thyroid cancer patients. These observations support their potential utility as minimally invasive biomarkers for thyroid carcinomas and their application in management of these diseases upon future validation.

Published
2024
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5. Nuclear heterogeneous nuclear ribonucleoprotein D is associated with poor prognosis and interactome analysis reveals its novel binding partners in oral cancer

Author

Kumar, Manish, primary, Matta, Ajay, additional, Masui, Olena, additional, Srivastava, Gunjan, additional, Kaur, Jatinder, additional, Thakar, Alok, additional, Shukla, Nootan Kumar, additional, RoyChoudhury, Ajoy, additional, Sharma, Meherchand, additional, Walfish, Paul G., additional, Michael Siu, K. W., additional, Chauhan, Shyam Singh, additional, and Ralhan, Ranju, additional

Published
2015
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6. Lactate Dehydrogenase A is a potential prognostic marker in clear cell renal cell carcinoma

Author

Girgis, Hala, primary, Masui, Olena, additional, White, Nicole MA, additional, Scorilas, Andreas, additional, Rotondo, Fabio, additional, Seivwright, Annetta, additional, Gabril, Manal, additional, Filter, Emily R, additional, Girgis, Andrew HA, additional, Bjarnason, Georg A, additional, Jewett, Michael AS, additional, Evans, Andrew, additional, Al-Haddad, Sahar, additional, Siu, KW Michael, additional, and Yousef, George M, additional

Published
2014
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7. Quantitative proteomic analysis reveals potential diagnostic markers and pathways involved in pathogenesis of renal cell carcinoma

Author

White, Nicole M.A., primary, Masui, Olena, additional, DeSouza, Leroi V., additional, Krakovska, Olga, additional, Metias, Shereen, additional, Romaschin, Alexander D., additional, Honey, R. John, additional, Stewart, Robert, additional, Pace, Kenneth, additional, Lee, Jason, additional, Jewett, Michael AS, additional, Bjarnason, Georg A., additional, Siu, K.W. Michael, additional, and Yousef, George M., additional

Published
2014
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10. Quantitative Proteomic Analysis in Metastatic Renal Cell Carcinoma Reveals a Unique Set of Proteins with Potential Prognostic Significance

Author

Masui, Olena, primary, White, Nicole M.A., additional, DeSouza, Leroi V., additional, Krakovska, Olga, additional, Matta, Ajay, additional, Metias, Shereen, additional, Khalil, Bishoy, additional, Romaschin, Alexander D., additional, Honey, R. John, additional, Stewart, Robert, additional, Pace, Kenneth, additional, Bjarnason, Georg A., additional, Siu, K.W. Michael, additional, and Yousef, George M., additional

Published
2013
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14. Additional file 3: of Nuclear heterogeneous nuclear ribonucleoprotein D is associated with poor prognosis and interactome analysis reveals its novel binding partners in oral cancer

Author

Kumar, Manish, Matta, Ajay, Masui, Olena, Srivastava, Gunjan, Kaur, Jatinder, Thakar, Alok, Nootan Shukla, Ajoy RoyChoudhury, Meherchand Sharma, Walfish, Paul, K. Michael Siu, Chauhan, Shyam, and Ranju Ralhan

Subjects
3. Good health
Abstract

Table S1. List of key proteins identified as binding partners of hnRNPD in OSCC cells (SCC-4 / MDA1986) using IP-LC-MS/MS.

15. Additional file 3: of Nuclear heterogeneous nuclear ribonucleoprotein D is associated with poor prognosis and interactome analysis reveals its novel binding partners in oral cancer

Author

Kumar, Manish, Matta, Ajay, Masui, Olena, Srivastava, Gunjan, Kaur, Jatinder, Thakar, Alok, Nootan Shukla, Ajoy RoyChoudhury, Meherchand Sharma, Walfish, Paul, K. Michael Siu, Chauhan, Shyam, and Ranju Ralhan

Subjects
3. Good health
Abstract

Table S1. List of key proteins identified as binding partners of hnRNPD in OSCC cells (SCC-4 / MDA1986) using IP-LC-MS/MS.

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