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1. Estimating motor unit numbers from a CMAP scan:Repeatability study on three muscles at 15 centres

Author

Sørensen, D. M., Bostock, H., Abrahao, A., Alaamel, A., Alaydin, H. C., Ballegaard, M., Boran, E., Cengiz, B., de Carvalho, M., Dunker, Fuglsang-Frederiksen, A., Graffe, C. C., Jones, K. E., Kallio, M., Kalra, S., Krarup, C., Krøigård, T., Liguori, R., Lupescu, T., Maitland, S., Matamala, J. M., Moldovan, M., Moreno-Roco, J., Nilsen, K. B., Phung, L., Santos, M. O., Themistocleous, A. C., Uysal, H., Vacchiano, V., Whittaker, R. G., Zinman, L., Tankisi, H., Sørensen, D. M., Bostock, H., Abrahao, A., Alaamel, A., Alaydin, H. C., Ballegaard, M., Boran, E., Cengiz, B., de Carvalho, M., Dunker, Fuglsang-Frederiksen, A., Graffe, C. C., Jones, K. E., Kallio, M., Kalra, S., Krarup, C., Krøigård, T., Liguori, R., Lupescu, T., Maitland, S., Matamala, J. M., Moldovan, M., Moreno-Roco, J., Nilsen, K. B., Phung, L., Santos, M. O., Themistocleous, A. C., Uysal, H., Vacchiano, V., Whittaker, R. G., Zinman, L., and Tankisi, H.

Abstract

Objective: To assess the repeatability and suitability for multicentre studies of MScanFit motor unit number estimation (MUNE), which involves modelling compound muscle action potential (CMAP) scans. Methods: Fifteen groups in 9 countries recorded CMAP scans twice, 1–2 weeks apart in healthy subjects from abductor pollicis brevis (APB), abductor digiti minimi (ADM) and tibialis anterior (TA) muscles. The original MScanFit program (MScanFit-1) was compared with a revised version (MScanFit-2), designed to accommodate different muscles and recording conditions by setting the minimal motor unit size as a function of maximum CMAP. Results: Complete sets of 6 recordings were obtained from 148 subjects. CMAP amplitudes differed significantly between centres for all muscles, and the same was true for MScanFit-1 MUNE. With MScanFit-2, MUNE differed less between centres but remained significantly different for APB. Coefficients of variation between repeats were 18.0% for ADM, 16.8% for APB, and 12.1% for TA. Conclusions: It is recommended for multicentre studies to use MScanFit-2 for analysis. TA provided the least variable MUNE values between subjects and the most repeatable within subjects. Significance: MScanFit was primarily devised to model the discontinuities in CMAP scans in patients and is less suitable for healthy subjects with smooth scans.

Published
2023

8. Cortical inexcitability defines an adverse clinical profile in amyotrophic lateral sclerosis.

Author

Dharmadasa, T., Howells, J., Matamala, J. M., Simon, N. G., Burke, D., Vucic, S., and Kiernan, M. C.

Subjects
AMYOTROPHIC lateral sclerosis, EVOKED potentials (Electrophysiology), TRANSCRANIAL magnetic stimulation, SURVIVAL analysis (Biometry), MOTOR cortex
Abstract

Background and purpose: In amyotrophic lateral sclerosis, studies using threshold‐tracking transcranial magnetic stimulation (TMS) have identified corticomotoneuronal dysfunction as a key pathogenic mechanism. Some patients, however, display no motor response at maximal TMS intensities, termed here an 'inexcitable' motor cortex. The extent to which this cortical difference impacts clinical outcomes remains unclear. The aim of this study was to determine the clinical profile of patients with inexcitability to TMS. Methods: Motor cortex excitability was evaluated using TMS. Patients in whom a motor evoked potential could not be recorded in one or more limbs at maximal TMS intensities were classified as four‐limb or partially inexcitable. Demographic information, clinical variables and survival data were analysed. Results: From 133 patients, 40 were identified with inexcitability. Patients with four‐limb inexcitability were younger (P = 0.03) and had lower‐limb disease onset (64%), greater functional disability (P < 0.001) and faster disease progression (P = 0.02), particularly if inexcitability developed within 1 year of symptoms (P < 0.01). Patients with partial inexcitability had higher resting motor thresholds compared to the excitable cohort (P < 0.01), but averaged short‐interval intracortical inhibition was similar (P = 0.5). Mean survival was reduced if inexcitability involved all limbs within 12 months of symptom onset (P = 0.04). Conclusion: Amyotrophic lateral sclerosis patients with inexcitability of all four limbs to TMS have a distinct clinical profile of younger age and lower‐limb onset. Importantly, these patients display a more malignant disease trajectory, with faster progression, greater functional disability and reduced survival when occurring in early disease. This measure may provide an important prognostic marker in amyotrophic lateral sclerosis. [ABSTRACT FROM AUTHOR]

Published
2021
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9. The addition of fermented milk with plant sterols improves the adherence to lifestyle changes in hypercholesterolemic patients. The RECIPE study

Author

Masana L., Lagares M., Pinto X., Reinares L., Zuniga M., Descamps O., Bosi E., Allaert F. A., Chapman J., Bruckert E., Hernandez T., Martin C., Gomes H., Perez P. J., Gil E. M., Moro A., Jorda M. D., Lopez J. L., Alba M., Bilbao I., Alustiza M. R., Aliaga M., Munoz J. G., Terol A. M., Gomez P., Marcos M. A., Gonzalez M., Rodriguez M. J., Lopez M. V., Romero M. A., Puyo N., Egido J. F., Monreal I., Ramirez A., Madariaga M. A., De Miguel M. C., Lorda A., Munoz G., Moreno I. M., Martinez A., Sanchez A., Espino A., Gonzalez. F. J., Pracht C., Ocana C., Pena M. A., Domingo C., Gilaberte M. T., Garcia C., Diez J. A., Fornes F. V., Gutierrez M. D., Macarra E., Bugella J. I., Del. J. M., Bravo A., Becerra M. J., Carbonell C., De Miguel M., Perez A., Martin A., Romero J., Gonzalez P., Iglesias A., Lopez B., Villalonga G., Carvajal P., Marin C., Cardona F., Gonzalez A., Fernandez G., Gomez D., Sanchez C. L., Viveros D., De Lucas M. G., Marin J. M., Osorno J., Pumares C., Gimenez R., Latorre J., Barreiro M. C., Villanueva J. R., Lopez J. A., Balaguer I., Baron J., Espuga M., Firas R., Trias F., Moran A., Velasco V., Vazquez F., Hernando A., Manzanares A., Abad J. L., Peraferrer M., Obarrio A., Alonso M. L., Gomez L., Roca J., Ayus B. E., Urban F., Gonzalez E., Masegosa C., Barrilero E., Jimenez M. C., Carratala M. M., Petitbo D., Ferrandiz J., Mialdea M. J., Montoro J., Muncharaz M. E., Shehchar A., De Paula L., Cano A., Sanchez L., Perez J., Alarcon C., Martinez J. F., Garrido T., Martinez F., Gomariz I., Caparros M., Kseibi T., Palomo L., Jimenez T., Luque I., Villar P., Gonzalez J. J., Aparicio J., Jimenez O., Munoz J. J., Baez F., Marcos M. P., Gonzalez T., Estevez J. A., Garcia J., Ajuria-Gogeasko S., Cabrera M., Manzano J. M., Segura G., Abat X., Yanovsky N., Borrachero J. M., Fortuny M., Martinez M. D., Gutierrez A. R., Najem N., Romero M. C., Martin S., Valverde R. J., Molina C., Martinez B., Izquierdo L., Vazquez I., Martinez M. T., Mateos A., Quiles F., Aranda F. J., Iborra R., Valero A. B., Fornes M. T., Quinza V., Colado F., Arribas B., Martinez J. E. L., Garces M. P., Valero J. M., Frigola J. L., Rubio J. M., Gongora A., Triana J., Gomez C., Garcia M. L., Diez C., Pombo G., Gutierrez M. C., Nazara C. A., De Oca M. A., Maquieira N., Pilo A., Buenadicha J. L., Duran F., Pena J. E., Navarro S., Serrano F. J., Sanchez S., Mesa S., Salazar J. A., De La Escosura A., Perez F., Solera J., Tarraga P., Ramos L., Gutierrez J. A., Caldelas S., Albinana F., Lopez J. F., Florian J., Rocha E., Rodriguez J., Mellado M. L., Calvillo M. R., Cruz T., Capitan M., Diaz J., Tome J., Prieto A., Tome V., Caro M., Montero A., Ontoria M., Garcia D. L., Gil F., De Zarate V., Casaponsa J., Matamala J., Salvande A., Trueba M. A., Cidra J. L., Garcia A., Toro A., Berna J. R., Zornoza B., Prieto M. T., Garcia L., Lopez C., Garcia P., Echegaray M. C., Navarro B., Moro M. L., Herrero A., Tamargo C., Perez S. J., Antero E., Penacho M. C., Blanco Y., Lucena J., Sisto C. A., Salido E., Dolz F., Granja J. M., Saavedra F., Sanchez-Oro I., Mas-Magro F., Artundo T., Fernandez A., Vaquer J. V., Aso K., Palacios A., Morante J. L., Seller T., Vendrell J. M., Masana, L., Lagares, M., Pinto, X., Reinares, L., Zuniga, M., Descamps, O., Bosi, E., Allaert, F. A., Chapman, J., Bruckert, E., Hernandez, T., Martin, C., Gomes, H., Perez, P. J., Gil, E. M., Moro, A., Jorda, M. D., Lopez, J. L., Alba, M., Bilbao, I., Alustiza, M. R., Aliaga, M., Munoz, J. G., Terol, A. M., Gomez, P., Marcos, M. A., Gonzalez, M., Rodriguez, M. J., Lopez, M. V., Romero, M. A., Puyo, N., Egido, J. F., Monreal, I., Ramirez, A., Madariaga, M. A., De Miguel, M. C., Lorda, A., Munoz, G., Moreno, I. M., Martinez, A., Sanchez, A., Espino, A., Gonzale, z. F. J., Pracht, C., Ocana, C., Pena, M. A., Domingo, C., Gilaberte, M. T., Garcia, C., Diez, J. A., Fornes, F. V., Gutierrez, M. D., Macarra, E., Bugella, J. I., De, l. J. M., Bravo, A., Becerra, M. J., Carbonell, C., De Miguel, M., Perez, A., Martin, A., Romero, J., Gonzalez, P., Iglesias, A., Lopez, B., Villalonga, G., Carvajal, P., Marin, C., Cardona, F., Gonzalez, A., Fernandez, G., Gomez, D., Sanchez, C. L., Viveros, D., De Lucas, M. G., Marin, J. M., Osorno, J., Pumares, C., Gimenez, R., Latorre, J., Barreiro, M. C., Villanueva, J. R., Lopez, J. A., Balaguer, I., Baron, J., Espuga, M., Firas, R., Trias, F., Moran, A., Velasco, V., Vazquez, F., Hernando, A., Manzanares, A., Abad, J. L., Peraferrer, M., Obarrio, A., Alonso, M. L., Gomez, L., Roca, J., Ayus, B. E., Urban, F., Gonzalez, E., Masegosa, C., Barrilero, E., Jimenez, M. C., Carratala, M. M., Petitbo, D., Ferrandiz, J., Mialdea, M. J., Montoro, J., Muncharaz, M. E., Shehchar, A., De Paula, L., Cano, A., Sanchez, L., Perez, J., Alarcon, C., Martinez, J. F., Garrido, T., Martinez, F., Gomariz, I., Caparros, M., Kseibi, T., Palomo, L., Jimenez, T., Luque, I., Villar, P., Gonzalez, J. J., Aparicio, J., Jimenez, O., Munoz, J. J., Baez, F., Marcos, M. P., Gonzalez, T., Estevez, J. A., Garcia, J., Ajuria-Gogeasko, S., Cabrera, M., Manzano, J. M., Segura, G., Abat, X., Yanovsky, N., Borrachero, J. M., Fortuny, M., Martinez, M. D., Gutierrez, A. R., Najem, N., Romero, M. C., Martin, S., Valverde, R. J., Molina, C., Martinez, B., Izquierdo, L., Vazquez, I., Martinez, M. T., Mateos, A., Quiles, F., Aranda, F. J., Iborra, R., Valero, A. B., Fornes, M. T., Quinza, V., Colado, F., Arribas, B., Martinez, J. E. L., Garces, M. P., Valero, J. M., Frigola, J. L., Rubio, J. M., Gongora, A., Triana, J., Gomez, C., Garcia, M. L., Diez, C., Pombo, G., Gutierrez, M. C., Nazara, C. A., De Oca, M. A., Maquieira, N., Pilo, A., Buenadicha, J. L., Duran, F., Pena, J. E., Navarro, S., Serrano, F. J., Sanchez, S., Mesa, S., Salazar, J. A., De La Escosura, A., Perez, F., Solera, J., Tarraga, P., Ramos, L., Gutierrez, J. A., Caldelas, S., Albinana, F., Lopez, J. F., Florian, J., Rocha, E., Rodriguez, J., Mellado, M. L., Calvillo, M. R., Cruz, T., Capitan, M., Diaz, J., Tome, J., Prieto, A., Tome, V., Caro, M., Montero, A., Ontoria, M., Garcia, D. L., Gil, F., De Zarate, V., Casaponsa, J., Matamala, J., Salvande, A., Trueba, M. A., Cidra, J. L., Garcia, A., Toro, A., Berna, J. R., Zornoza, B., Prieto, M. T., Garcia, L., Lopez, C., Garcia, P., Echegaray, M. C., Navarro, B., Moro, M. L., Herrero, A., Tamargo, C., Perez, S. J., Antero, E., Penacho, M. C., Blanco, Y., Lucena, J., Sisto, C. A., Salido, E., Dolz, F., Granja, J. M., Saavedra, F., Sanchez-Oro, I., Mas-Magro, F., Artundo, T., Fernandez, A., Vaquer, J. V., Aso, K., Palacios, A., Morante, J. L., Seller, T., and Vendrell, J. M.

Subjects
Hypercholesterolemia, Phytosterol, Fermented milk, Lifestyle, Diet
Abstract

Introduction: RECIPE study was designed to assess the impact of dietary supplementation with fermented milk enriched with plant sterols (FMPS) on the nutritional behavior, lifestyle and the joint therapeutic responsibility of hypercholesterolemic patients. Methods: Observational, prospective, multicenter, international study, was conducted to assess dietary habits and other lifestyle components in hypercholesterolemic patients in whom the general practitioner indicated FMPS supplementation. Nutritional, lifestyle and clinical data were collected at the initial visit and after a 4 months follow-up. The biochemical and anthropometric data were retrieved from medical records obtained at baseline and 4 months. Results: We report the results of Spain. Two hundred and one physicians who provided valid data of 1044 patients participated. The addition of FMPS was associated with improved overall nutritional index, being adequate initially in 28.2% of patients, and increasing up to 75.2% at the end of the study (P< 001). This nutritional change was associated with an improvement in the lipid profile and anthropometric data. Patients more adherent to therapy generally achieved a better result in all parameters compared to non-compliant ones. Conclusions: The addition of FMPS to a diet designed to reduce the LDL enhances the patient's attitude regarding changes in lifestyle, leading to better overall control of dyslipidemia and anthropometric improvement. © 2012 Elsevier España, S.L. and SEA.

Published
2012

10. Análisis y comparación de ciclos termodinámicos para la generación de potencia a partir de recursos geotermales nacionales e media y alta entalpía

Author

Matamala, J., Valencia, Alvaro, Morata, Diego, and Universidad de Chile

Abstract

El aumento progresivo en los costos de producción de electricidad en nuestro país, sumado al déficit que se prevé que este insumo presentará considerando el crecimiento gradual de su demanda frente a la cobertura actual de su oferta, se debe, entre otras INGENIERO CIVIL MECÁNICO FONDAP FONDAP CEGA

Published
2014

11. Improving health through policies that promote active travel: A review of evidence to support integrated health impact assessment

Author

de Nazelle, A, Nieuwenhuijsen, MJ, Anto, JM, Brauer, M, Briggs, D, Braun-Fahrlander, C, Cavill, N, Cooper, AR, Desqueyroux, H, Fruin, S, Hoek, G, Panis, LI, Janssen, N, Jerrett, M, Joffe, M, Andersen, ZJ, van Kempen, E, Kingham, S, Kubesch, N, Leyden, KM, Marshall, JD, Matamala, J, Mellios, G, Mendez, M, Nassif, H, Ogilvie, D, Peiro, R, Perez, K, Rabl, A, Ragettli, M, Rodriguez, D, Rojas, D, Ruiz, P, Sallis, JF, Terwoert, J, Toussaint, JF, Tuomisto, J, Zuurbier, M, and Lebret, E

Subjects
Built environment, Physical activity, Air pollution, Cycling, Walking, Risk assessment
Abstract

Background: Substantial policy changes to control obesity, limit chronic disease, and reduce air pollution emissions, including greenhouse gasses, have been recommended. Transportation and planning policies that promote active travel by walking and cycling can contribute to these goals, potentially yielding further co-benefits. Little is known, however, about the interconnections among effects of policies considered, including potential unintended consequences. Objectives and methods: We review available literature regarding health impacts from policies that encourage active travel in the context of developing health impact assessment (HIA) models to help decision-makers propose better solutions for healthy environments. We identify important components of HIA models of modal shifts in active travel in response to transport policies and interventions. Results and discussion: Policies that increase active travel are likely to generate large individual health benefits through increases in physical activity for active travelers. Smaller, but population-wide benefits could accrue through reductions in air and noise pollution. Depending on conditions of policy implementations, risk tradeoffs are possible for some individuals who shift to active travel and consequently increase inhalation of air pollutants and exposure to traffic injuries. Well-designed policies may enhance health benefits through indirect outcomes such as improved social capital and diet, but these synergies are not sufficiently well understood to allow quantification at this time. Conclusion: Evaluating impacts of active travel policies is highly complex; however, many associations can be quantified. Identifying health-maximizing policies and conditions requires integrated HIAs. (C) 2011 Elsevier Ltd. All rights reserved.

Published
2011

12. Ceramic production in the northwestern Iberian Peninsula: studying the functional features of pottery by analyzing organic material

Author

Prieto-Martínez, M. Pilar, Juan Tresserras, Jordi, and Matamala, J. C.

Subjects
Landscape Archaeology Laboratory, Patrimonio Cultural, Cultural Heritage, Período galaico-romano, Laboratorio de Arqueología del Paisaje, Galicia, Neolítico tardío, Heritage Laboratory, LAr, Technological Operative Chain, Galaico-Roman period, Laboratorio de Patrimonio, Cadena Tecnológica Operativa, Late Neolithic, LaPa
Abstract

[ES] En este artículo ofrecemos una interpretación preliminar de los resultados analíticos de materia orgánica procedente de cerámica encontrada en once yacimientos en Galicia, en el noroeste de la Península Ibérica. Los yacimientos pertenecen a distintos períodos cronológicos, desde el Neolítico tardío hasta el período galaico-romano. Empezamos con una breve presentación de los contextos, luego un resumen de los materiales cerámicos y finalmente presentamos los resultados del análisis. Las cerámicas fueron estudiadas aplicando el concepto teórico y metodológico de "Cadena Tecnológica Operativa" (Cobas y Prieto 2003). Esta es la primera vez que un proyecto de investigación de este tipo y alcance has sido puesto en práctica en Galicia. [EN] In this article we offer a preliminary interpretation of analytical results of organic material taken from pottery found in eleven sites in Galicia, in the northwestern Iberian Peninsula. The sites are from different chronological periods, ranging from the Late Neolithic until the Galaico-Roman period. We start with a short presentation of the contexts, then a summary of the ceramic materials, and finally present the results of the analyses. The ceramics were studied applying the theoretical and methodological concept of the "Technological Operative Chain" (Cobas and Prieto 2003). This is the first time that an investigation project of this type and scope has been carried out in Galicia.

Published
2005

19. Neuro-otological findings in tinnitus patients with normal hearing.

Author

MORALES-GARCIA, C., QUIROZ, G., MATAMALA, J. M., and TAPIA, C.

Subjects
TINNITUS, OTOLOGY, NEUROLOGY, COCHLEA, HEARING, DISEASES, PATIENTS
Abstract

Introduction: Tinnitus is usually associated with hearing loss, and patients with tinnitus and normal hearing are unusual. Neuro-otological findings have not previously been described in tinnitus patients with normal hearing. Aim: To analyse neuro-otological examination results from a group of tinnitus patients with normal hearing. Materials and methods: Seventeen normal-hearing tinnitus patients seen over a 10-year period were retrospectively evaluated. Their results were compared with those of a control group of 17 normal subjects without tinnitus. Results: The main neuro-otological finding in the tinnitus patients was caloric test abnormality: a unilateral canal paresis was present in 15 of the 17 patients. Caloric tests were normal in 15 of the 17 control subjects. Conclusion: We may infer from these results that tinnitus could be the only clinical manifestation of a cochlear -- and presumably cochleo-vestibular -- lesion, and that unilateral canal paresis may be the only abnormal finding on neuro-otological examination. [ABSTRACT FROM AUTHOR]

Published
2010
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20. Estimating motor unit numbers from a CMAP scan: Repeatability study on three muscles at 15 centres.

Author

Sørensen DM, Bostock H, Abrahao A, Alaamel A, Alaydin HC, Ballegaard M, Boran E, Cengiz B, de Carvalho M, Dunker Ø, Fuglsang-Frederiksen A, Graffe CC, Jones KE, Kallio M, Kalra S, Krarup C, Krøigård T, Liguori R, Lupescu T, Maitland S, Matamala JM, Moldovan M, Moreno-Roco J, Nilsen KB, Phung L, Santos MO, Themistocleous AC, Uysal H, Vacchiano V, Whittaker RG, Zinman L, and Tankisi H

Subjects
Humans, Action Potentials physiology, Healthy Volunteers, Electromyography, Motor Neurons physiology, Muscle, Skeletal diagnostic imaging, Muscle, Skeletal physiology
Abstract

Objective: To assess the repeatability and suitability for multicentre studies of MScanFit motor unit number estimation (MUNE), which involves modelling compound muscle action potential (CMAP) scans., Methods: Fifteen groups in 9 countries recorded CMAP scans twice, 1-2 weeks apart in healthy subjects from abductor pollicis brevis (APB), abductor digiti minimi (ADM) and tibialis anterior (TA) muscles. The original MScanFit program (MScanFit-1) was compared with a revised version (MScanFit-2), designed to accommodate different muscles and recording conditions by setting the minimal motor unit size as a function of maximum CMAP., Results: Complete sets of 6 recordings were obtained from 148 subjects. CMAP amplitudes differed significantly between centres for all muscles, and the same was true for MScanFit-1 MUNE. With MScanFit-2, MUNE differed less between centres but remained significantly different for APB. Coefficients of variation between repeats were 18.0% for ADM, 16.8% for APB, and 12.1% for TA., Conclusions: It is recommended for multicentre studies to use MScanFit-2 for analysis. TA provided the least variable MUNE values between subjects and the most repeatable within subjects., Significance: MScanFit was primarily devised to model the discontinuities in CMAP scans in patients and is less suitable for healthy subjects with smooth scans., (Copyright © 2023. Published by Elsevier B.V.)

Published
2023
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21. Quantitative muscle ultrasound as a biomarker in Charcot-Marie-Tooth neuropathy.

Author

Shahrizaila N, Noto Y, Simon NG, Huynh W, Shibuya K, Matamala JM, Dharmadasa T, Devenney E, Kennerson ML, Nicholson GA, and Kiernan MC

Subjects
Adult, Charcot-Marie-Tooth Disease physiopathology, Female, Humans, Male, Middle Aged, Muscle, Skeletal physiopathology, Neural Conduction physiology, Prospective Studies, Charcot-Marie-Tooth Disease diagnostic imaging, Muscle, Skeletal diagnostic imaging, Ultrasonography methods
Abstract

Objective: The utility of quantitative muscle ultrasound as a marker of disease severity in Charcot-Marie-Tooth (CMT) disease subtypes was investigated., Methods: Muscle ultrasound was prospectively performed on 252 individual muscles from 21 CMT patients (9 CMT1A, 8 CMTX1, 4 CMT2A) and compared to 120 muscles from 10 age and gender-matched controls. Muscle ultrasound recorded echogenicity and thickness in representative muscles including first dorsal interosseus (FDI) and tibialis anterior (TA)., Results: Muscle volume of FDI and thickness of TA correlated with MRC strength. Muscle echogenicity was significantly increased in FDI (65.05 vs 47.09; p<0.0001) and TA (89.45 vs 66.30; p<0.0001) of CMT patients. In TA, there was significantly higher muscle thickness (23 vs 18 vs 16mm; p<0.0001) and lower muscle echogenicity (80 vs 95 vs 108; p<0.0001) in CMT1A compared to CMTX1 and CMT2A. This corresponded to disease severity based on muscle strength (MRC grading CMT1A vs CMTX1 vs CMT2A: 59 vs 48 vs 44; p=0.002)., Conclusion: In CMT, quantitative muscle ultrasound of FDI and TA is a useful marker of disease severity., Significance: The current findings suggest that quantitative muscle ultrasound has potential as a surrogate marker of disease progression in future interventional trials in CMT., (Copyright © 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.)

Published
2017
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22. [Extrapulmonary pneumocystosis: a case report].

Author

Valdebenito C, Bonacic M, Matamala J, and Wolff M

Subjects
Adult, Humans, Male, AIDS-Related Opportunistic Infections diagnosis, Pneumocystis Infections diagnosis, Pneumocystis carinii
Abstract

We report a case of a middle-age male patient, with newly HIV infection in AIDS stage diagnosis, no comorbitidies, who was hospitalized for subacute malaise, fever, self-limited unproductive cough and no bloody chronic diarrea. The diagnosis of Pneumocystis jiroveci pneumonia was performed by imagenological suspicion and stains of cysts of this pathogen with bronchoalveolar lavage samples. Treatment was initiated with oral cotrimoxazole and starting HAART with good clinical outcome. Concomitantly, an etiologic study was conducted for chronic diarrhea and through histopathological examination of colonic mucosa, numerous extracellular cystic structures Pneumocystis characteristics were observed, performing the diagnosis of extrapulmonary pneumocystosis. Extrapulmonary pneumocystosis is a rare cause of P. jiroveci infection, requires a high index of suspicion and should be approached in HIV patients with severe AIDS which is common in co-infection of various infections and is peremptory to make an etiologic diagnosis and early treatment.

Published
2015
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23. Improving estimates of air pollution exposure through ubiquitous sensing technologies.

Author

de Nazelle A, Seto E, Donaire-Gonzalez D, Mendez M, Matamala J, Nieuwenhuijsen MJ, and Jerrett M

Subjects
Activities of Daily Living, Adult, Female, Geographic Information Systems, Humans, Inhalation Exposure analysis, Male, Spain, Air Pollution statistics & numerical data, Environmental Monitoring methods, Inhalation Exposure statistics & numerical data
Abstract

Traditional methods of exposure assessment in epidemiological studies often fail to integrate important information on activity patterns, which may lead to bias, loss of statistical power, or both in health effects estimates. Novel sensing technologies integrated with mobile phones offer potential to reduce exposure measurement error. We sought to demonstrate the usability and relevance of the CalFit smartphone technology to track person-level time, geographic location, and physical activity patterns for improved air pollution exposure assessment. We deployed CalFit-equipped smartphones in a free-living population of 36 subjects in Barcelona, Spain. Information obtained on physical activity and geographic location was linked to space-time air pollution mapping. We found that information from CalFit could substantially alter exposure estimates. For instance, on average travel activities accounted for 6% of people's time and 24% of their daily inhaled NO2. Due to the large number of mobile phone users, this technology potentially provides an unobtrusive means of enhancing epidemiologic exposure data at low cost., (Copyright © 2013 Elsevier Ltd. All rights reserved.)

Published
2013
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24. Improving health through policies that promote active travel: a review of evidence to support integrated health impact assessment.

Author

de Nazelle A, Nieuwenhuijsen MJ, Antó JM, Brauer M, Briggs D, Braun-Fahrlander C, Cavill N, Cooper AR, Desqueyroux H, Fruin S, Hoek G, Panis LI, Janssen N, Jerrett M, Joffe M, Andersen ZJ, van Kempen E, Kingham S, Kubesch N, Leyden KM, Marshall JD, Matamala J, Mellios G, Mendez M, Nassif H, Ogilvie D, Peiró R, Pérez K, Rabl A, Ragettli M, Rodríguez D, Rojas D, Ruiz P, Sallis JF, Terwoert J, Toussaint JF, Tuomisto J, Zuurbier M, and Lebret E

Subjects
Accidents, Traffic statistics & numerical data, Air Pollution adverse effects, Air Pollution statistics & numerical data, Bicycling statistics & numerical data, Environmental Exposure statistics & numerical data, Environmental Policy, Health Behavior, Health Status, Hot Temperature adverse effects, Humans, Noise, Transportation adverse effects, Noise, Transportation statistics & numerical data, Sunlight adverse effects, Walking statistics & numerical data, Exercise, Health Policy, Transportation statistics & numerical data, Travel
Abstract

Background: Substantial policy changes to control obesity, limit chronic disease, and reduce air pollution emissions, including greenhouse gasses, have been recommended. Transportation and planning policies that promote active travel by walking and cycling can contribute to these goals, potentially yielding further co-benefits. Little is known, however, about the interconnections among effects of policies considered, including potential unintended consequences., Objectives and Methods: We review available literature regarding health impacts from policies that encourage active travel in the context of developing health impact assessment (HIA) models to help decision-makers propose better solutions for healthy environments. We identify important components of HIA models of modal shifts in active travel in response to transport policies and interventions., Results and Discussion: Policies that increase active travel are likely to generate large individual health benefits through increases in physical activity for active travelers. Smaller, but population-wide benefits could accrue through reductions in air and noise pollution. Depending on conditions of policy implementations, risk tradeoffs are possible for some individuals who shift to active travel and consequently increase inhalation of air pollutants and exposure to traffic injuries. Well-designed policies may enhance health benefits through indirect outcomes such as improved social capital and diet, but these synergies are not sufficiently well understood to allow quantification at this time., Conclusion: Evaluating impacts of active travel policies is highly complex; however, many associations can be quantified. Identifying health-maximizing policies and conditions requires integrated HIAs., (Copyright © 2011 Elsevier Ltd. All rights reserved.)

Published
2011
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25. Diminished response to food deprivation of the rat brown adipose tissue mitochondrial uncoupling system with age.

Author

Garcia-Palmer FJ, Pericas J, Matamala JC, Puigserver P, Bonet ML, Palou A, and Gianotti M

Subjects
Adipose Tissue, Brown physiology, Age Factors, Animals, Body Temperature Regulation physiology, Body Weight physiology, Electron Transport Complex IV metabolism, Female, Guanosine Diphosphate metabolism, Mitochondria chemistry, Organ Size physiology, Proteins chemistry, Rats, Rats, Wistar, Starvation, Adipose Tissue physiology, Food Deprivation, Mitochondria physiology
Abstract

The aim of the present work is to investigate the effect of starvation on brown adipose tissue thermogenic activity with aging. Interscapular brown adipose tissue from female Wistar rats of different ages was used; half of them were fed and the other half were starved for 24 hours. Mitochondria were isolated and mitochondrial protein content, GDP-binding, Cytochrome-c Oxidase activity and uncoupling protein levels were measured. Results show a decrease of all studied parameters, indicating a diminished thermogenic activity with age. The response to starvation is almost the same in all the parameters studied: a general reduction with starvation and a progressive disappearance of this response to starvation with aging. On the whole, these results would indicate a deficient regulation of brown adipose tissue thermogenic activity in old animals, as it happens in other animal models with an alterated thermogenesis.

Published
1997
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27. Changes induced by fasting and dietetic obesity in thermogenic parameters of rat brown adipose tissue mitochondrial subpopulations.

Author

Matamala JC, Gianotti M, Pericás J, Quevedo S, Roca P, Palou A, and García-Palmer FJ

Subjects
Adipose Tissue, Brown ultrastructure, Animals, Carrier Proteins genetics, Diet, Energy Metabolism, Fasting, Female, Ion Channels, Membrane Proteins genetics, Mitochondrial Proteins, Obesity, RNA, Messenger metabolism, Rats, Rats, Wistar, Uncoupling Protein 1, Adipose Tissue, Brown metabolism, Carrier Proteins metabolism, Membrane Proteins metabolism, Mitochondria metabolism
Abstract

The effects of starvation on the thermogenic parameters of three different mitochondrial subpopulations in brown adipose tissue (BAT) of both post-cafeteria obese and lean rats were investigated. Tissue from different BAT depots from fed and 24 h starved rats were collected, pooled and three mitochondrial subpopulations were isolated by differential centrifugation; the M1 fraction (1000 g), the M3 fraction (3000 g) and the M15 fraction (15,000 g). Thermogenic parameters were measured in the three mitochondrial subtypes, and uncoupling protein (UCP) mRNA was determined in BAT. The results showed that starvation induced a decrease in mitochondrial turnover in BAT from both lean and obese rats. Moreover, a selective net loss of UCP from the lightest mitochondrial fraction (M15) in lean rats, with a concomitant reduction of UCP mRNA was observed. The reductions did not occur in obese rats and, as a result, a change in UCP distribution between the mitochondrial subpopulations was produced, with an increase in the M1 mitochondrial subtype. The lack of response of UCP to starvation observed in BAT of obese rats compared with the decrease seen in lean animals, is a consequence of a different mitochondrial subpopulation composition and/or a different response of a particular subpopulation to starvation.

Published
1996
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28. In vitro interactions between nuclear proteins and uncoupling protein gene promoter reveal several putative transactivating factors including Ets1, retinoid X receptor, thyroid hormone receptor, and a CACCC box-binding protein.

Author

Cassard-Doulcier AM, Larose M, Matamala JC, Champigny O, Bouillaud F, and Ricquier D

Subjects
Adipose Tissue, Brown metabolism, Animals, Base Sequence, CHO Cells, Carrier Proteins metabolism, Cells, Cultured, Cricetinae, Deoxyribonuclease I metabolism, Ion Channels, Liver metabolism, Membrane Proteins metabolism, Mice, Mitochondria metabolism, Mitochondrial Proteins, Molecular Sequence Data, Proto-Oncogene Proteins c-ets, Rats, Receptors, Cytoplasmic and Nuclear metabolism, Retinoid X Receptors, Transcription Factors metabolism, Transcriptional Activation, Uncoupling Protein 1, Carrier Proteins genetics, DNA-Binding Proteins metabolism, Membrane Proteins genetics, Oncogene Proteins, Promoter Regions, Genetic, Receptors, Retinoic Acid, Receptors, Thyroid Hormone metabolism
Abstract

Previous studies of rat ucp (uncoupling protein) gene organization carried out in this laboratory identified regulatory sequences located in the 5'-flanking region. In this work, DNase I footprint analysis of the enhancer revealed two domains at base pairs (bp) -2444 to -2423 and bp -2352 to -2319. The former domain can bind in vitro, in a cooperative manner, factors related to nuclear factor 1 and Ets1; the latter domain contains a type 3 directly repeated sequence that was shown to be able to bind the retinoid X and triiodothyronine receptors. Moreover, a positive effect of retinoic acid on ucp mRNA levels in immortalized brown adipocytes was observed. DNase I footprint analysis identified two hypersensitive regions, A and B, at bp -509 to -472 and bp -403 to -350, respectively; region A contains a repeated CACCC box, and region B can bind protein related to Ets1. The A box differentially binds liver and brown adipose tissue nuclear proteins and could be involved in uncoupling protein induction. Further analysis showed three foot-printed boxes, C-E, at bp -182 to -159, -147 to -120, and -111 to -85, able to bind in vitro proteins related to nuclear factor 1, cAMP response element-binding protein, and Sp1, respectively.

Published
1994

29. Metabolic utilization of muscular L-proline in 24-hr starved rats.

Author

Pericas J, Pico C, Matamala JC, Palou A, and Pons A

Subjects
Animals, Female, Intestinal Mucosa metabolism, Liver metabolism, Proline blood, Rats, Rats, Wistar, Starvation blood, Muscles metabolism, Proline metabolism, Starvation metabolism
Abstract

1. The aim of this paper was to study the in vivo skeletal muscle L-proline related to its destination to other key tissues such as liver and intestine as well as to give some insight into the role of blood cells in proline handling. 2. L-U-[14C]Proline was injected intramuscularly and following by sampling of blood, liver, intestine and contralateral muscle at 20 and 30 min after injection. 3. The distribution of radioactivity between blood cells and plasma and in total and individual amino acids, protein and glycogen fractions was determined in the above tissues. 4. The pattern of well fed rats was compared with those submitted to 24-hr complete starvation. 5. During starvation a minor degree of proline oxidation occurs. 6. The main destruction of proline in the liver seem to be the synthesis of proteins. 7. The radioactivity recovered in the blood proline fraction of starved rats is twice that of the fed rats and that it could be attributed mainly to plasma protein. 8. We have obtained in vivo evidence for the role of erythrocyte in the interorgan proline transport.

Published
1992
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