Search

Your search keyword '"Matarese, F."' showing total 154 results
Start Over Author "Matarese, F."
154 results on '"Matarese, F."'

2. A multi-block method to improve 2D tracking in outdoor Augmented Reality applications

Author

Magrini M., Magnavacca J., and Matarese F.

Subjects
Augmented-reality, Image Tracking and recognition, Unity3D
Abstract

Augmented reality techniques have recently found many applications in the field of cultural heritage. This work describes an example of application in Pinocchio Park (Collodi, Italy). Several recognition problems arise during the on-site test, due to unstable light conditions. The authors propose a solution based on a multi-blocks image target segmentation and a dedicated add-on for the Unity3D game engine.

Published
2022
Full Text
View/download PDF

3. SI-Lab annual research report 2021

Author

Righi M., Leone G. R., Carboni A., Caudai C., Colantonio S., Kuruoglu E. E., Leporini B., Magrini M., Paradisi P., Pascali M. A., Pieri G., Reggiannini M., Salerno E., Scozzari A., Tonazzini A., Fusco G., Galesi G., Martinelli M., Pardini F., Tampucci M., Berti A., Bruno A., Buongiorno R., Carloni G., Conti F., Germanese D., Ignesti G., Matarese F., Omrani A., Pachetti E., Papini O., Benassi A., Bertini G., Coltelli P., Tarabella L., Straface S., Salvetti O., and Moroni D.

Subjects
Human-Computer Interaction, Artificial Intelligence, Signal Processing, Intelligent systems, Topological data analysis, Quality-of-Life, Computer vision, Inclusion and accessibility
Abstract

The Signal & Images Laboratory is an interdisciplinary research group in computer vision, signal analysis, intelligent vision systems and multimedia data understanding. It is part of the Institute of Information Science and Technologies (ISTI) of the National Research Council of Italy (CNR). This report accounts for the research activities of the Signal and Images Laboratory of the Institute of Information Science and Technologies during the year 2021.

Published
2022

4. Venturino Venturi e la Piazzetta dei Mosaici del Parco di Pinocchio

Author

Matarese F. and Magrini M.

Subjects
Patrimonio Culturale, Realtà Aumentata, Unity3D
Abstract

Nel cuore del Parco dedicato al burattino più famoso del mondo si trova un'opera straordinaria: una piazzetta quadrangolare di 30 m di lato, interamente mosaicata, che offre al visitatore un eccezionale crocevia artistico delle figure che popolano la storia di Pinocchio. Venturino Venturi, che insieme agli architetti Renato Baldi e Lionello De Luigi ha realizzato il progetto, ha dato vita a un ludus estetico spiazzante e fiabesco che continua a risuonare con elementi della contemporaneità, ispirando le nuove tecnologie digitali: la realtà aumentata infatti permetterà una visione inedita di questo spazio magico. Un'indagine su un grande artista del Novecento italiano, sulla sua opera maggiore e sul suo rapporto con Pinocchio, che lo ha accompagnato artisticamente ed esistenzialmente per tutta la vita, diventando un vero e proprio simbolo della sua poetica

Published
2021

6. Augmented reality and intelligent systems in Industry 4.0

Author

Benassi A., Carboni A., Colantonio S., Coscetti S., Germanese D., Jalil B., Leone R., Magnavacca J., Magrini M., Martinelli M., Matarese F., Moroni D., Paradisi P., Pardini F., Pascali M., Pieri G., Reggiannini M., Righi M., Salvetti O., Tampucci M., Istituto di Scienza e Tecnologie dell'Informazione 'A. Faedo' (ISTI), and Consiglio Nazionale delle Ricerche [Roma] (CNR)

Subjects
Artificial intelligence, Software_OPERATINGSYSTEMS, Hardware_MEMORYSTRUCTURES, Topological data analysis, [INFO.INFO-CV]Computer Science [cs]/Computer Vision and Pattern Recognition [cs.CV], 020206 networking & telecommunications, Augmented reality, 02 engineering and technology, Industry 4.0, Intelligent systems, Human-computer interaction, [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI], [INFO.INFO-MC]Computer Science [cs]/Mobile Computing, Statistical signal processing, [INFO.INFO-LG]Computer Science [cs]/Machine Learning [cs.LG], 0202 electrical engineering, electronic engineering, information engineering, Computer vision, [INFO]Computer Science [cs], 020201 artificial intelligence & image processing
Abstract

This presentation was delivered in the framework of Artes 4.0 seminars. It deals with the applicationof computer vision, intelligent systems and AR/VR/MR/XR technologies to Industry 4.0.

Published
2020
Full Text
View/download PDF

7. Potential impact of celiac disease genetic risk factors on T cell receptor signaling in gluten-specific CD4+T cells

Author

Bakker, Olivier B., Ramirez-Sanchez, Aaron D., Borek, Zuzanna A., Klein, Niek de, Li, Y., Modderman, Rutger, Matarese, F., Martens, J.H.A., Kumar, V., Withoff, Sebo, Jonkers, Iris H., Bakker, Olivier B., Ramirez-Sanchez, Aaron D., Borek, Zuzanna A., Klein, Niek de, Li, Y., Modderman, Rutger, Matarese, F., Martens, J.H.A., Kumar, V., Withoff, Sebo, and Jonkers, Iris H.

Abstract

Contains fulltext : 235047.pdf (Publisher’s version ) (Open Access)

Published
2021

9. Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes

Author

Yi, G., Wierenga, A., Petraglia, F., Narang, P., Janssen-Megens, E., Mandoli, A., Merkel, A., Berentsen, K., Kim, B., Matarese, F., Singh, A., Habibi, E., Prange, K., Mulder, A., Jansen, J., Clarke, L., Heath, S., van der Reijden, B., Flicek, P., Yaspo, M., Gut, I., Bock, C., Schuringa, J., Altucci, L., Vellenga, E., Stunnenberg, H., Martens, J., H., A., Yi, Guoqiang, Wierenga, Albertus T. J., Petraglia, Francesca, Narang, Pankaj, Janssen-Megens, Eva M., Mandoli, Amit, Merkel, Angelika, Berentsen, Kim, Kim, Bowon, Matarese, Filomena, Singh, Abhishek A., Habibi, Ehsan, Prange, Koen H. M., Mulder, André B., Jansen, Joop H., Clarke, Laura, Heath, Simon, van der Reijden, Bert A., Flicek, Paul, Yaspo, Marie-Laure, Gut, Ivo, Bock, Christoph, Schuringa, Jan Jacob, Altucci, Lucia, Vellenga, Edo, Stunnenberg, Hendrik G., Martens, Joost H. A., Medical Biochemistry, ACS - Atherosclerosis & ischemic syndromes, Stem Cell Aging Leukemia and Lymphoma (SALL), and Guided Treatment in Optimal Selected Cancer Patients (GUTS)

Subjects
Spliceosome, NPM1, Oncogene Proteins, Fusion, chromatin state, Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2], DNA accessibility, epigenome, Biology, acute myeloid leukemia, Article, General Biochemistry, Genetics and Molecular Biology, stemness, 03 medical and health sciences, chemistry.chemical_compound, All institutes and research themes of the Radboud University Medical Center, 0302 clinical medicine, AML, hemic and lymphatic diseases, Humans, chromatin states, histone mark, Molecular Biology, 030304 developmental biology, Genetics, 0303 health sciences, Biochemistry, Genetics and Molecular Biology (all), histone marks, Nuclear Proteins, Myeloid leukemia, Epigenome, Phenotype, Chromatin, stemne, Leukemia, Myeloid, Acute, Histone, RUNX1, chemistry, 030220 oncology & carcinogenesis, Core Binding Factor Alpha 2 Subunit, Mutation, biology.protein, transcriptome, Nucleophosmin, human activities
Abstract

Summary Global investigation of histone marks in acute myeloid leukemia (AML) remains limited. Analyses of 38 AML samples through integrated transcriptional and chromatin mark analysis exposes 2 major subtypes. One subtype is dominated by patients with NPM1 mutations or MLL-fusion genes, shows activation of the regulatory pathways involving HOX-family genes as targets, and displays high self-renewal capacity and stemness. The second subtype is enriched for RUNX1 or spliceosome mutations, suggesting potential interplay between the 2 aberrations, and mainly depends on IRF family regulators. Cellular consequences in prognosis predict a relatively worse outcome for the first subtype. Our integrated profiling establishes a rich resource to probe AML subtypes on the basis of expression and chromatin data.

Published
2019

10. Erratum: miR-194-5p/BCLAF1 deregulation in AML tumorigenesis

Author

Dell'Aversana, C, primary, Giorgio, C, additional, D'Amato, L, additional, Lania, G, additional, Matarese, F, additional, Saeed, S, additional, Di Costanzo, A, additional, Belsito Petrizzi, V, additional, Ingenito, C, additional, Martens, J H A, additional, Pallavicini, I, additional, Minucci, S, additional, Carissimo, A, additional, Stunnenberg, H G, additional, and Altucci, L, additional

Published
2017
Full Text
View/download PDF

12. Time-resolved analysis of DNA-protein interactions in living cells by UV laser pulses

Author

Nebbioso, A, Benedetti, R., Conte, M., Carafa, V., Bellis, F. de, Shaik, J., Matarese, F., Della Ventura, B., Gesuele, F., Velotta, R., Martens, J.H.A., Stunnenberg, H.G., Altucci, C., Altucci, L., Nebbioso, A, Benedetti, R., Conte, M., Carafa, V., Bellis, F. de, Shaik, J., Matarese, F., Della Ventura, B., Gesuele, F., Velotta, R., Martens, J.H.A., Stunnenberg, H.G., Altucci, C., and Altucci, L.

Abstract

Contains fulltext : 178024.pdf (publisher's version ) (Open Access)

Published
2017

13. Mir-194-5p/BCLAF1 deregulation in AML tumorigenesis

Author

Dell'aversana, C., Giorgio, C., D'Amato, L., Lania, G., Matarese, F., Saeed, S., Di Costanzo, A., Belsito Petrizzi, V., Ingenito, C., Martens, J.H.A., Pallavicini, I., Minucci, S., Carissimo, A., Stunnenberg, H., Altucci, L., Dell'aversana, C., Giorgio, C., D'Amato, L., Lania, G., Matarese, F., Saeed, S., Di Costanzo, A., Belsito Petrizzi, V., Ingenito, C., Martens, J.H.A., Pallavicini, I., Minucci, S., Carissimo, A., Stunnenberg, H., and Altucci, L.

Abstract

Contains fulltext : 168891.pdf (publisher's version ) (Open Access), Deregulation of epigenetic mechanisms, including microRNA, contributes to leukemogenesis and drug resistance by interfering with cancer-specific molecular pathways. Here, we show that the balance between miR-194-5p and its newly discovered target BCL2-associated transcription factor 1 (BCLAF1) regulates differentiation and survival of normal hematopoietic progenitors. In acute myeloid leukemias this balance is perturbed, locking cells into an immature, potentially /`immortal/' state. Enhanced expression of miR-194-5p by treatment with the histone deacetylase inhibitor SAHA or by exogenous miR-194-5p expression re-sensitizes cells to differentiation and apoptosis by inducing BCLAF1 to shuttle between nucleus and cytosol. miR-194-5p/BCLAF1 balance was found commonly deregulated in 60 primary acute myeloid leukemia patients and was largely restored by ex vivo SAHA treatment. Our findings link treatment responsiveness to re-instatement of miR-194-5p/BCLAF1 balance.

Published
2017

14. EPIGENETIC-BASED DRUGS IN STEM CELL DIFFERENTIATION

Author

FRANCI G., MENAFRA R., LAMBAZZI G., CASALINO L., RADIC B., TARALLO V., BENEDETTI R., MATARESE F., PETRAGLIA F., BALDI, Alfonso, STUNNENBERG H. G., ALTUCCI, Lucia, Franci, G., Menafra, R., Lambazzi, G., Casalino, L., Radic, B., Tarallo, V., Benedetti, R., Matarese, F., Petraglia, F., Baldi, Alfonso, Stunnenberg, H. G., and Altucci, Lucia

Published
2010

15. miR-194-5p/BCLAF1 deregulation in AML tumorigenesis

Author

Dell'Aversana, C, primary, Giorgio, C, additional, D'Amato, L, additional, Lania, G, additional, Matarese, F, additional, Saeed, S, additional, Di Costanzo, A, additional, Belsito Petrizzi, V, additional, Ingenito, C, additional, Martens, J H A, additional, Pallavicini, I, additional, Minucci, S, additional, Carissimo, A, additional, Stunnenberg, H G, additional, and Altucci, L, additional

Published
2017
Full Text
View/download PDF

16. Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells

Author

Chen, L., Ge, B., Casale, F.P., Vasquez, L., Kwan, T., Garrido-Martin, D., Watt, S., Yan, Y., Kundu, K., Ecker, S., Datta, A., Richardson, D., Burden, F., Mead, D., Mann, A.L., Fernandez, J.M., Rowlston, S., Wilder, S.P., Farrow, S., Shao, X., Lambourne, J.J., Redensek, A., Albers, C.A., Amstislavskiy, V., Ashford, S., Berentsen, K., Bomba, L., Bourque, G., Bujold, D., Busche, S., Caron, M., Chen, S.H., Cheung, W., Delaneau, O., Dermitzakis, E.T., Elding, H., Colgiu, I., Bagger, F.O., Flicek, P., Habibi, E., Iotchkova, V., Janssen-Megens, E., Kim, B., Lehrach, H., Lowy, E., Mandoli, A., Matarese, F., Maurano, M.T., Morris, J.A., Pancaldi, V., Pourfarzad, F., Rehnstrom, K., Rendon, A., Risch, T., Sharifi, N., Simon, M.M., Sultan, M., Valencia, A., Walter, K., Wang, S.Y., Frontini, M., Antonarakis, S.E., Clarke, L., Yaspo, M.L., Beck, S., Guigo, R., Rico, D., Martens, J.H., Ouwehand, W.H., Kuijpers, T.W., Paul, D.S., Stunnenberg, H.G., Stegle, O., Downes, K., Pastinen, T., Soranzo, N., Chen, L., Ge, B., Casale, F.P., Vasquez, L., Kwan, T., Garrido-Martin, D., Watt, S., Yan, Y., Kundu, K., Ecker, S., Datta, A., Richardson, D., Burden, F., Mead, D., Mann, A.L., Fernandez, J.M., Rowlston, S., Wilder, S.P., Farrow, S., Shao, X., Lambourne, J.J., Redensek, A., Albers, C.A., Amstislavskiy, V., Ashford, S., Berentsen, K., Bomba, L., Bourque, G., Bujold, D., Busche, S., Caron, M., Chen, S.H., Cheung, W., Delaneau, O., Dermitzakis, E.T., Elding, H., Colgiu, I., Bagger, F.O., Flicek, P., Habibi, E., Iotchkova, V., Janssen-Megens, E., Kim, B., Lehrach, H., Lowy, E., Mandoli, A., Matarese, F., Maurano, M.T., Morris, J.A., Pancaldi, V., Pourfarzad, F., Rehnstrom, K., Rendon, A., Risch, T., Sharifi, N., Simon, M.M., Sultan, M., Valencia, A., Walter, K., Wang, S.Y., Frontini, M., Antonarakis, S.E., Clarke, L., Yaspo, M.L., Beck, S., Guigo, R., Rico, D., Martens, J.H., Ouwehand, W.H., Kuijpers, T.W., Paul, D.S., Stunnenberg, H.G., Stegle, O., Downes, K., Pastinen, T., and Soranzo, N.

Abstract

Contains fulltext : 167824.pdf (Publisher’s version ) (Open Access)

Published
2016

17. beta-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance

Author

Novakovic, B., Habibi, E., Wang, S.Y., Arts, R.J., Davar, R., Megchelenbrink, W., Kim, B., Kuznetsova, T., Kox, M., Zwaag, J., Matarese, F., Heeringen, S.J. van, Janssen-Megens, E.M., Sharifi, N., Wang, C., Keramati, F., Schoonenberg, V., Flicek, P., Clarke, L., Pickkers, P., Heath, S., Gut, I., Netea, M.G., Martens, J.H., Logie, C., Stunnenberg, H.G., Novakovic, B., Habibi, E., Wang, S.Y., Arts, R.J., Davar, R., Megchelenbrink, W., Kim, B., Kuznetsova, T., Kox, M., Zwaag, J., Matarese, F., Heeringen, S.J. van, Janssen-Megens, E.M., Sharifi, N., Wang, C., Keramati, F., Schoonenberg, V., Flicek, P., Clarke, L., Pickkers, P., Heath, S., Gut, I., Netea, M.G., Martens, J.H., Logie, C., and Stunnenberg, H.G.

Abstract

Contains fulltext : 165879.pdf (publisher's version ) (Open Access), Innate immune memory is the phenomenon whereby innate immune cells such as monocytes or macrophages undergo functional reprogramming after exposure to microbial components such as lipopolysaccharide (LPS). We apply an integrated epigenomic approach to characterize the molecular events involved in LPS-induced tolerance in a time-dependent manner. Mechanistically, LPS-treated monocytes fail to accumulate active histone marks at promoter and enhancers of genes in the lipid metabolism and phagocytic pathways. Transcriptional inactivity in response to a second LPS exposure in tolerized macrophages is accompanied by failure to deposit active histone marks at promoters of tolerized genes. In contrast, beta-glucan partially reverses the LPS-induced tolerance in vitro. Importantly, ex vivo beta-glucan treatment of monocytes from volunteers with experimental endotoxemia re-instates their capacity for cytokine production. Tolerance is reversed at the level of distal element histone modification and transcriptional reactivation of otherwise unresponsive genes. VIDEO ABSTRACT.

Published
2016

18. The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-ETO Oncogene Overexpression and Onset of the Apoptosis Program in t(8;21) AMLs

Author

Mandoli, A., Singh, A.A., Prange, K.H.M., Tijchon, E., Oerlemans, M., Dirks, R.A.M., Huurne, M.C. ter, Wierenga, A.T., Janssen-Megens, E.M., Berentsen, K., Sharifi, N., Kim, B., Matarese, F., Nguyen, L.N., Hubner, N.C., Rao, N.A.S., van den Akker, E., Altucci, L., Vellenga, E., Stunnenberg, H., Martens, J.H.A., Mandoli, A., Singh, A.A., Prange, K.H.M., Tijchon, E., Oerlemans, M., Dirks, R.A.M., Huurne, M.C. ter, Wierenga, A.T., Janssen-Megens, E.M., Berentsen, K., Sharifi, N., Kim, B., Matarese, F., Nguyen, L.N., Hubner, N.C., Rao, N.A.S., van den Akker, E., Altucci, L., Vellenga, E., Stunnenberg, H., and Martens, J.H.A.

Abstract

Contains fulltext : 163345.pdf (publisher's version ) (Open Access), The t(8;21) acute myeloid leukemia (AML)-associated oncoprotein AML1-ETO disrupts normal hematopoietic differentiation. Here, we have investigated its effects on the transcriptome and epigenome in t(8,21) patient cells. AML1-ETO binding was found at promoter regions of active genes with high levels of histone acetylation but also at distal elements characterized by low acetylation levels and binding of the hematopoietic transcription factors LYL1 and LMO2. In contrast, ERG, FLI1, TAL1, and RUNX1 bind at all AML1-ETO-occupied regulatory regions, including those of the AML1-ETO gene itself, suggesting their involvement in regulating AML1-ETO expression levels. While expression of AML1-ETO in myeloid differentiated induced pluripotent stem cells (iPSCs) induces leukemic characteristics, overexpression increases cell death. We find that expression of wild-type transcription factors RUNX1 and ERG in AML is required to prevent this oncogene overexpression. Together our results show that the interplay of the epigenome and transcription factors prevents apoptosis in t(8;21) AML cells.

Published
2016

19. Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131

Author

Varier, R. A., Carrillo de Santa Pau, E., van der Groep, P., Lindeboom, R.G.H., Matarese, F., Mensinga, A., Smits, A.H., Edupuganti, V.S.R.R., Baltissen, M.P., Jansen, P. W., Ter Hoeve, N., van Weely, D.R., Poser, I., van Diest, P.J., Stunnenberg, H., Vermeulen, M., Varier, R. A., Carrillo de Santa Pau, E., van der Groep, P., Lindeboom, R.G.H., Matarese, F., Mensinga, A., Smits, A.H., Edupuganti, V.S.R.R., Baltissen, M.P., Jansen, P. W., Ter Hoeve, N., van Weely, D.R., Poser, I., van Diest, P.J., Stunnenberg, H., and Vermeulen, M.

Abstract

Contains fulltext : 161825.pdf (publisher's version ) (Open Access)

Published
2016

20. ZMYND8 Co-localizes with NuRD on Target Genes and Regulates Poly(ADP-Ribose)-Dependent Recruitment of GATAD2A/NuRD to Sites of DNA Damage

Author

Spruijt, C.G., Luijsterburg, M.S., Menafra, R., Lindeboom, R.G.H., Jansen, P. W., Edupuganti, V.S.R.R., Baltissen, M.P., Wiegant, W.W., Voelker-Albert, M.C., Matarese, F., Mensinga, A., Poser, I., Vos, H.R., Stunnenberg, H., van Attikum, H., Vermeulen, M., Spruijt, C.G., Luijsterburg, M.S., Menafra, R., Lindeboom, R.G.H., Jansen, P. W., Edupuganti, V.S.R.R., Baltissen, M.P., Wiegant, W.W., Voelker-Albert, M.C., Matarese, F., Mensinga, A., Poser, I., Vos, H.R., Stunnenberg, H., van Attikum, H., and Vermeulen, M.

Abstract

Contains fulltext : 161839.pdf (publisher's version ) (Open Access)

Published
2016

21. eFORGE: A Tool for Identifying Cell Type-Specific Signal in Epigenomic Data

Author

Breeze, C.E., Paul, D.S., van Dongen, J., Butcher, L.M., Ambrose, J.C., Barrett, J.E., Lowe, R., Rakyan, V.K., Iotchkova, V., Frontini, M., Downes, K., Ouwehand, W.H., Laperle, J., Jacques, P.E., Bourque, G., Bergmann, A.K., Siebert, R., Vellenga, E., Saeed, S., Matarese, F., Martens, J.H.A., Stunnenberg, H., Teschendorff, A.E., Herrero, J., Birney, E., Dunham, I., Beck, S., Breeze, C.E., Paul, D.S., van Dongen, J., Butcher, L.M., Ambrose, J.C., Barrett, J.E., Lowe, R., Rakyan, V.K., Iotchkova, V., Frontini, M., Downes, K., Ouwehand, W.H., Laperle, J., Jacques, P.E., Bourque, G., Bergmann, A.K., Siebert, R., Vellenga, E., Saeed, S., Matarese, F., Martens, J.H.A., Stunnenberg, H., Teschendorff, A.E., Herrero, J., Birney, E., Dunham, I., and Beck, S.

Abstract

Contains fulltext : 161675.pdf (publisher's version ) (Open Access)

Published
2016

23. Genotyping of Italian regional grapevine accessions by SNPs analysis

Author

D’Onofrio, C., Barbagallo, M. G., Bignami, Cristina, Crespan, M., DE MICHELE, M., DE PALMA, L, Imazio, Serena Anna, Matarese, F, Mercati, F., Morcia, C., Muganu, M, Novello, V., Nuzzo, V., Pilo, L., Raimondi, S., Ruffa, P., Sacco, L., Scalabrelli, G., Schneider, A., and Storchi, P.

Subjects
molecular markers, Vitis vinifera, Vitis vinifera, grapevine, germplasm, identification, molecular markers, identification, germplasm, grapevine
Published
2014

30. Genomic view of estrogen actions in hormone responsive breast cancer cells

Author

WEISZ A, CICATIELLO L, CAPORALI S, IMAI M, CARISTI S, CANCEMI M, MATARESE F, FACCHIANO A, CALOGERO R, BRESCIANI F., ALTUCCI, Lucia, Weisz, A, Cicatiello, L, Caporali, S, Imai, M, Caristi, S, Cancemi, M, Matarese, F, Altucci, Lucia, Facchiano, A, Calogero, R, and Bresciani, F.

Published
2001

32. Estrogens do not modify MAP kinase-dependent nuclear signaling during stimulation of early G(1) progression in human breast cancer cells

Author

Caristi S, Jl, Galera, Matarese F, Imai M, Caporali S, Cancemi M, Altucci L, Cicatiello L, Teti D, Bresciani F, Alessandro Weisz, Caristi, S, Galera, Jl, Matarese, F, Imai, M, Caporali, S, Cancemi, M, Altucci, Lucia, Cicatiello, L, Teti, D, Bresciani, F, and Weisz, A.

Subjects
Cell Nucleus, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase Kinases, Mitogen-Activated Protein Kinase 3, Estradiol, MAP Kinase Kinase 4, MAP Kinase Signaling System, Estrogens, human breast cancer cells, G1 Phase, JNK Mitogen-Activated Protein Kinases, MAP Kinase Kinase Kinase 1, Breast Neoplasms, Protein Serine-Threonine Kinases, Cyclic AMP-Dependent Protein Kinases, Retinoblastoma Protein, p38 Mitogen-Activated Protein Kinases, Gene Expression Regulation, Neoplastic, Tumor Cells, Cultured, Humans, Cyclin D1, Mitogen-Activated Protein Kinases, Phosphorylation
Abstract

Estrogens are direct mitogens for hormone-responsive human breast cancercells, where they promote cell cycle progression and induce transcriptional activation of "immediate early" and cyclin genes. Nongenomic signaling by estrogens, including rapid changes of mitogen-activated protein(MAP) kinase and other signal-transduction-cascades activity, has been proposed to be essential for the mitogenic actions of these hormones and their nuclear receptors. Because regulation of gene transcription is considered a key step in cell cycle control by mitogenic protein kinase cascades, here we investigated the possibility that estrogen might induce the activation of extracellular signal-regulated kinase (Erk) 1/2-, c-Jun NH(2)-terminal kinase-, p38- or protein kinase A-responsive transcription factors in the cell nucleus during stimulation of early G(1) progression, a timing coincident with the maximum effects of these hormones on such enzyme activity. No significant changes in protein kinase-mediated transcription factor activity could be detected here after estrogen stimulation of either MCF-7 or ZR-75.1 cells. Furthermore, these steroids were able to induce activation of the human CCND1 gene promoter, accumulation of cyclin D1 and pRb phosphorylation, all key events in cell cycle stimulation by mitogens, even in the presence of Erk1/2 activation blockade by a MAP kinase-activating kinase (Mek)1/2 inhibitor. Thus, estrogens do not appear to convey significant protein kinase-dependent signaling to the cell nucleus during the early phases of human breast cancer cell stimulation. Furthermore, hormonal regulation of G(1) gene transcription can occur even without additional activation of the Mek-Erk1/2 pathway by estrogen receptors.

Published
2001

33. DON on wheat crop residues: effects on mycobiota as a source of potential antagonists of Fusarium culmorum

Author

Sarrocco, S., Matarese, F., Moretti, A., EDITH MIRIAM HAIDUKOWSKI, and Vannacci, G.

Subjects
lcsh:Botany, deoxynivalenol, food and beverages, biological control, straw competition, mycobiota, lcsh:QK1-989
Abstract

Fusarium culmorum, a pathogenic fungal species associated with Fusarium Head Blight (FHB) of wheat, can produce the mycotoxin deoxynivalenol (DON) that is frequently found as contaminant in cereals. Wheat haulms, as decomposing plant material, are an important inoculum source of F. culmorum for subsequent crops. In the present work we exploited the mycobiota of haulms buried in natural soil as a source of potential antagonists of F. culmorum and evaluated the role played by DON in determining the composition of such mycobiota. DON was added to wheat haulm pieces that were incubated in three natural soils, namely sandy, clayey and mixed, all with a previous history of wheat cultivation. Composition of mycobiota associated with DON-treated cultural debris was evaluated and compared with mycobiota from control haulms, in order to evaluate the effect of soil type and of the presence of the mycotoxin. Our results showed that DON affected neither the number nor species profile of fungal isolates. Among fungi associated with cultural debris, thirty-nine Pythium spp. isolates were collected and five of them, both from treated and not treated haulms, were tested for their antagonistic ability against F. culmorum. The two strains showing the highest antagonistic activity were further tested against F. oxysporum, a species considered a major competitor of F. culmorum for wheat residues, and frequently recovered from haulms in our experiments. The two Pythium spp. isolates showed a positive antagonistic and mycoparasitic activity against F. culmorum, without affecting the growth of F. oxysporum. Mycobiota of haulms buried in soil represents an interesting source of potential antagonists and competitors for future exploitation in a multitrophic approach for biocontrol of FHB.

Published
2012

37. Genome-wide modeling of transcription kinetics reveals patterns of RNA production delays

Author

Honkela, A., Peltonen, J., Topa, H., Charapitsa, I., Matarese, F., Grote, K., Stunnenberg, H.G., Reid, G., Lawrence, N.D., Rattray, M., Honkela, A., Peltonen, J., Topa, H., Charapitsa, I., Matarese, F., Grote, K., Stunnenberg, H.G., Reid, G., Lawrence, N.D., and Rattray, M.

Abstract

Contains fulltext : 149102.pdf (Publisher’s version ) (Closed access)

Published
2015

38. Physiological parameters and protective energy dissipation mechanisms expressed in the leaves of two Vitis vinifera L. genotypes under multiple summer stresses

Author

Palliotti, A., Tombesi, Sergio, Frioni, Tommaso, Silvestroni, O., Lanari, V., D'Onofrio, C., Matarese, F., Bellincontro, A., Poni, Stefano, Tombesi, Sergio (ORCID:0000-0002-5126-0561), Frioni, Tommaso (ORCID:0000-0002-8663-3022), Poni, Stefano (ORCID:0000-0002-7238-2613), Palliotti, A., Tombesi, Sergio, Frioni, Tommaso, Silvestroni, O., Lanari, V., D'Onofrio, C., Matarese, F., Bellincontro, A., Poni, Stefano, Tombesi, Sergio (ORCID:0000-0002-5126-0561), Frioni, Tommaso (ORCID:0000-0002-8663-3022), and Poni, Stefano (ORCID:0000-0002-7238-2613)

Abstract

Photosynthetic performances and energy dissipation mechanisms were evaluated on the anisohydric cv. Sangiovese and on the isohydric cv. Montepulciano (Vitis vinifera L.) under conditions of multiple summer stresses. Potted vines of both cultivars were maintained at 90% and 40% of maximum water availability from fruit-set to veraison. One week before veraison, at predawn and midday, main gas-exchange and chlorophyll fluorescence parameters, chlorophyll content, xanthophyll pool and cycle and catalase activity were evaluated. Under water deficit and elevated irradiance and temperature, contrary to cv. Montepulciano and despite a significant leaf water potential decrease, Sangiovese's leaves kept their stomata more open and continued to assimilate CO2 while also showing higher water use efficiency. Under these environmental conditions, in comparison with the isohydric cv. Montepulciano, the protective mechanisms of energy dissipation exerted by the anisohydric cv. Sangiovese were: (i) higher stomatal conductance and thermoregulation linked to higher transpiration rate; (ii) greater ability at dissipating more efficiently the excess energy via the xanthophylls cycle activity (thermal dissipation) due to higher VAZ pool and greater increase of de-epoxidation activity.

Published
2015

41. Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

Author

Saeed, S., Quintin, J., Kerstens, H.H., Rao, N.A., Aghajanirefah, A., Matarese, F., Cheng, S.C., Ratter, J., Berentsen, K., Ent, M.A. van der, Sharifi, N., Janssen-Megens, E.M., Huurne, M.C. ter, Mandoli, A., Schaik, T. van, Ng, A., Burden, F., Downes, K., Frontini, M., Kumar, V., Giamarellos-Bourboulis, E.J., Ouwehand, W.H., Meer, J.W.M. van der, Joosten, L.A., Wijmenga, C., Martens, J.H., Xavier, R.J., Logie, C., Netea, M.G., Stunnenberg, H.G., Saeed, S., Quintin, J., Kerstens, H.H., Rao, N.A., Aghajanirefah, A., Matarese, F., Cheng, S.C., Ratter, J., Berentsen, K., Ent, M.A. van der, Sharifi, N., Janssen-Megens, E.M., Huurne, M.C. ter, Mandoli, A., Schaik, T. van, Ng, A., Burden, F., Downes, K., Frontini, M., Kumar, V., Giamarellos-Bourboulis, E.J., Ouwehand, W.H., Meer, J.W.M. van der, Joosten, L.A., Wijmenga, C., Martens, J.H., Xavier, R.J., Logie, C., Netea, M.G., and Stunnenberg, H.G.

Abstract

Item does not contain fulltext, Monocyte differentiation into macrophages represents a cornerstone process for host defense. Concomitantly, immunological imprinting of either tolerance or trained immunity determines the functional fate of macrophages and susceptibility to secondary infections. We characterized the transcriptomes and epigenomes in four primary cell types: monocytes and in vitro-differentiated naive, tolerized, and trained macrophages. Inflammatory and metabolic pathways were modulated in macrophages, including decreased inflammasome activation, and we identified pathways functionally implicated in trained immunity. beta-glucan training elicits an exclusive epigenetic signature, revealing a complex network of enhancers and promoters. Analysis of transcription factor motifs in deoxyribonuclease I hypersensitive sites at cell-type-specific epigenetic loci unveiled differentiation and treatment-specific repertoires. Altogether, we provide a resource to understand the epigenetic changes that underlie innate immunity in humans.

Published
2014

42. Context-selective death of acute myeloid leukemia cells triggered by the novel hybrid retinoid-hdac inhibitor mc2392

Author

Bellis, F. de, Carafa, V., Conte, M., Rotili, D., Petraglia, F., Matarese, F., Francoijs, C.J.J., Ablain, J., Valente, S., Castellano, R., Goubard, A., Collette, Y., Mandoli, A., Martens, J.H., The, H. de, Nebbioso, A., Mai, A., Stunnenberg, H.G., Altucci, L., Bellis, F. de, Carafa, V., Conte, M., Rotili, D., Petraglia, F., Matarese, F., Francoijs, C.J.J., Ablain, J., Valente, S., Castellano, R., Goubard, A., Collette, Y., Mandoli, A., Martens, J.H., The, H. de, Nebbioso, A., Mai, A., Stunnenberg, H.G., and Altucci, L.

Abstract

Item does not contain fulltext

Published
2014

44. Genome-wide binding of mbd2 reveals strong preference for highly methylated loci

Author

Menafra, R., Brinkman, A.B., Matarese, F., Franci, G., Bartels, S.J., Nguyen, L. Thi Ngoc, Shimbo, T., Wade, P.A., Hubner, N.C., Stunnenberg, H.G., Menafra, R., Brinkman, A.B., Matarese, F., Franci, G., Bartels, S.J., Nguyen, L. Thi Ngoc, Shimbo, T., Wade, P.A., Hubner, N.C., and Stunnenberg, H.G.

Abstract

Contains fulltext : 128075.pdf (publisher's version ) (Open Access)

Published
2014

48. Whole-genome bisulfite sequencing of two distinct interconvertible DNA methylomes of mouse embryonic stem cells

Author

Habibi, E., Brinkman, A.B., Arand, J., Kroeze, L., Kerstens, H.H., Matarese, F., Lepikhov, K., Gut, M., Brun-Heath, I., Hubner, N.C., Benedetti, R., Altucci, L., Jansen, J.H., Walter, J., Gut, I.G., Marks, H., Stunnenberg, H.G., Habibi, E., Brinkman, A.B., Arand, J., Kroeze, L., Kerstens, H.H., Matarese, F., Lepikhov, K., Gut, M., Brun-Heath, I., Hubner, N.C., Benedetti, R., Altucci, L., Jansen, J.H., Walter, J., Gut, I.G., Marks, H., and Stunnenberg, H.G.

Abstract

Contains fulltext : 128583.pdf (Publisher’s version ) (Closed access), The use of two kinase inhibitors (2i) enables derivation of mouse embryonic stem cells (ESCs) in the pluripotent ground state. Using whole-genome bisulfite sequencing (WGBS), we show that male 2i ESCs are globally hypomethylated compared to conventional ESCs maintained in serum. In serum, female ESCs are hypomethyated similarly to male ESCs in 2i, and DNA methylation is further reduced in 2i. Regions with elevated DNA methylation in 2i strongly correlate with the presence of H3K9me3 on endogenous retroviruses (ERVs) and imprinted loci. The methylome of male ESCs in serum parallels postimplantation blastocyst cells, while 2i stalls ESCs in a hypomethylated, ICM-like state. WGBS analysis during adaptation of 2i ESCs to serum suggests that deposition of DNA methylation is largely random, while loss of DNA methylation during reversion to 2i occurs passively, initiating at TET1 binding sites. Together, our analysis provides insight into DNA methylation dynamics in cultured ESCs paralleling early developmental processes.

Published
2013

50. Sequential ChIP-bisulfite sequencing enables direct genome-scale investigation of chromatin and DNA methylation cross-talk

Author

Brinkman, A.B., Gu, H., Bartels, S.J.J., Zhang, Y., Matarese, F., Simmer, F., Marks, H., Bock, C., Gnirke, A., Meissner, A., Stunnenberg, H.G., Brinkman, A.B., Gu, H., Bartels, S.J.J., Zhang, Y., Matarese, F., Simmer, F., Marks, H., Bock, C., Gnirke, A., Meissner, A., and Stunnenberg, H.G.

Abstract

Contains fulltext : 94090.pdf (preprint version ) (Open Access)

Published
2012

Catalog

Books, media, physical & digital resources
See catalog results