Search

Your search keyword '"Matchar, David Bruce"' showing total 230 results
Start Over Author "Matchar, David Bruce"
230 results on '"Matchar, David Bruce"'

2. Development of a real-world database for asthma and COPD: The SingHealth-Duke-NUS-GSK COPD and Asthma Real-World Evidence (SDG-CARE) collaboration

Author

Lam, Sean Shao Wei, Fang, Andrew Hao Sen, Koh, Mariko Siyue, Shantakumar, Sumitra, Yeo, See-Hwee, Matchar, David Bruce, Ong, Marcus Eng Hock, Poon, Ken Mei Ting, Huang, Liming, Harikrishan, Sudha, Milea, Dominique, Burke, Des, Webb, Dave, Ragavendran, Narayanan, Tan, Ngiap Chuan, and Loo, Chian Min

Published
2023
Full Text
View/download PDF

6. Health Services Use and Functional Recovery Following Blunt Trauma in Older Persons – A National Multicentre Prospective Cohort Study

Author

Wong, Ting-Hway, Tan, Timothy Xin Zhong, Malhotra, Rahul, Nadkarni, Nivedita V., Chua, Wei Chong, Loo, Lynette Ma, Iau, Philip Tsau Choong, Ang, Arron Seng Hock, Goo, Jerry Tiong Thye, Chan, Kim Chai, Matchar, David Bruce, Seow, Dennis Chuen Chai, Nguyen, Hai V., Ng, Yee Sien, Chan, Angelique, Fook-Chong, Stephanie, Tang, Tjun Yip, and Ong, Marcus Eng Hock

Published
2022
Full Text
View/download PDF

8. Mapping the value for money of precision medicine : a systematic literature review and meta-analysis

Author

Chen, Wenjia, Wong, Chong Boon Nigel, Wang, Yi, Zemlyanska, Yaroslava, Butani, Dimple, Virabhak, Suchin, Matchar, David Bruce, Prapinvanich, Thittaya, Teerawattananon, Yot, Chen, Wenjia, Wong, Chong Boon Nigel, Wang, Yi, Zemlyanska, Yaroslava, Butani, Dimple, Virabhak, Suchin, Matchar, David Bruce, Prapinvanich, Thittaya, and Teerawattananon, Yot

Abstract

Objective: This study aimed to quantify heterogeneity in the value for money of precision medicine (PM) by application types across contexts and conditions and to quantify sources of heterogeneity to areas of particular promises or concerns as the field of PM moves forward. Methods: A systemic search was performed in Embase, Medline, EconLit, and CRD databases for studies published between 2011 and 2021 on cost-effectiveness analysis (CEA) of PM interventions. Based on a willingness-to-pay threshold of one-time GDP per capita of each study country, the net monetary benefit (NMB) of PM was pooled using random-effects meta-analyses. Sources of heterogeneity and study biases were examined using random-effects meta-regressions, jackknife sensitivity analysis, and the biases in economic studies checklist. Results: Among the 275 unique CEAs of PM, publicly sponsored studies found neither genetic testing nor gene therapy cost-effective in general, which was contradictory to studies funded by commercial entities and early stage evaluations. Evidence of PM being cost-effective was concentrated in a genetic test for screening, diagnosis, or as companion diagnostics (pooled NMBs, $48,152, $8,869, $5,693, p < 0.001), in the form of multigene panel testing (pooled NMBs = $31,026, p < 0.001), which only applied to a few disease areas such as cancer and high-income countries. Incremental effectiveness was an essential value driver for varied genetic tests but not gene therapy. Conclusion: Precision medicine’s value for money across application types and contexts was difficult to conclude from published studies, which might be subject to systematic bias. The conducting and reporting of CEA of PM should be locally based and standardized for meaningful comparisons.

Published
2024

9. Validation and application of a needs-based segmentation tool for cross-country comparisons

Author

Duminy, Lize, Sivapragasam, Nirmali Ruth, Matchar, David Bruce, Visaria, Abhijit, Ansah, John Pastor, Blankart, Carl Rudolf, and Schoenenberger, Lukas

Subjects
Chronic diseases -- Care and treatment, Health care industry -- International aspects -- Comparative analysis, Health planning -- International aspects -- Comparative analysis, Health care industry, Business
Abstract

Objective: To compare countries' health care needs by segmenting populations into a set of needs-based health states. Data sources: We used seven waves of the Survey of Health, Aging and Retirement in Europe (SHARE) panel survey data. Study design: We developed the Cross-Country Simple Segmentation Tool (CCSST), a validated clinician-administered instrument for categorizing older individuals by distinct, homogeneous health and related social service needs. Using clinical indicators, self-reported physician diagnosis of chronic disease, and performance-based tests conducted during the survey interview, individuals were assigned to 1-5 global impressions (Gi) segments and assessed for having any of the four identifiable complicating factors (CFs). We used Cox proportional hazard models to estimate the risk of mortality by segment. First, we show the segmentation cross-sectionally to assess cross-country differences in the fraction of individuals with different levels of medical needs. Second, we compare the differences in the rate at which individuals transition between those levels and death. Data collection/extraction methods: We segmented 270,208 observations (from Austria, Belgium, Czech Republic, Denmark, France, Germany, Greece, Israel, Italy, the Netherlands, Poland, Spain, Sweden, and Switzerland) from 96,396 individuals into GI and CF categories. Principal findings: The CCSST is a valid tool for segmenting populations into needsbased states, showing Switzerland with the lowest fraction of individuals in high medical needs segments, followed by Denmark and Sweden, and Poland with the highest fraction, followed by Italy and Israel. Comparing hazard ratios of transitioning between health states may help identify country-specific areas for analysis of ecological and cultural risk factors. Conclusions: The CCSST is an innovative tool for aggregate cross-country comparisons of both health needs and transitions between them. A cross-country comparison gives policy makers an effective means of comparing national health system performance and provides targeted guidance on how to identify strategies for curbing the rise of high-need, high-cost patients. KEYWORDS access/demand/utilization of services, chronic disease, comparative health systems/international health, geriatrics, health care organizations and systems, integrated delivery systems, modeling: multi-level, survey research and questionnaire design What is known on this topic * Population segmentation is a promising approach for health care resource planning and policy making. * A number of needs-based segmentation approaches exist, which either are conceptual or use utilization-based metrics. * Needs-based segmentation studies are limited to regional data sources. What this study adds * The Cross-Country Simple Segmentation Tool (CCSST) segments individuals into five ordinal medical complexity categories, called 'Global Impressions' (Gl) segments, and identifies the presence of four patient characteristics, which, if present, would increase the complexity of care, called 'Complicating Factors' (CFs). * The CCSST is applied to the SHARE panel survey dataset and allows for comparisons across countries. * Our approach helps policy makers identify country-specific areas of analysis of services and factors that may confound transition rates., 1 | INTRODUCTION Chronic conditions have been called 'the healthcare challenge of this century' by the World Health Organization. (1) The prevalence of patients with numerous and complex health care [...]

Published
2021
Full Text
View/download PDF

13. Plasma Acylcarnitines as Metabolic Signatures of Declining Health-Related Quality of Life Measure in Community-Dwelling Older Adults: A Combined Cross-sectional and Longitudinal Pilot Study.

Author

Ng, Ted Kheng Siang, Wee, Hai Ning, Ching, Jianhong, Kovalik, Jean-Paul, Chan, Angelique W, and Matchar, David Bruce

Subjects
QUALITY of life, OLDER people, ADULTS, CARBON metabolism, LONGITUDINAL method
Abstract

Background Health-related quality of life (HRQoL) measures are predictors of adverse health outcomes in older adults. Studies have demonstrated cross-sectional associations between HRQoL measures and blood-based biochemical markers. Acylcarnitines (ACs) are a class of metabolites generated in the mitochondria and are predictive of multiple geriatric syndromes. Changes in ACs reflect alterations in central carbon metabolic pathways. However, the prospective relationship between plasma ACs and declining HRQoL has not been examined. This study aimed to investigate both cross-sectional and longitudinal associations of baseline ACs with baseline and declining EuroQol-5 Dimension/EuroQol Visual Analogue Scale (EQ-5D/EQ-VAS) in community-dwelling older adults. Methods One hundred and twenty community-dwelling older adults with EQ-5D/EQ-VAS measurements at baseline and follow-up were included. We quantified ACs at baseline using targeted plasma metabolomics profiling. Multivariate regressions were performed to examine cross-sectional and longitudinal associations between the measures. Results Cross-sectionally, ACs showed no significant associations with either EQ-5D index or EQ-VAS scores. Longitudinally, multiple baseline short-chain ACs were significantly and inversely associated with declining EQ-5D index score, explaining up to 8.5% of variance in the decline. Conclusions Within a cohort of community-dwelling older adults who had high HRQoL at baseline, we showed that higher levels of short-chain ACs are longitudinally associated with declining HRQoL. These findings reveal a novel association between central carbon metabolic pathways and declining HRQoL. Notably, dysregulation in mitochondrial central carbon metabolism could be detected prior to clinically important decline in HRQoL, providing the first evidence of objective biomarkers as novel predictors to monitor HRQoL in nonpharmacological interventions and epidemiology. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

17. Systems modelling as an approach for eliciting the mechanisms for hip fracture recovery among older adults in a participatory stakeholder engagement setting

Author

Ansah, John Pastor, primary, Chia, Aloysius Wei-Yan, additional, Koh, Vanessa Jean Wen, additional, Lai, Wei Xuan, additional, Koh, Joyce Suang Bee, additional, Goh, Kiat Sern, additional, Yeo, William, additional, Howe, Tet Sen, additional, Seow, Dennis Chuen Chai, additional, Mamun, Kaysar, additional, Balasubramanian, Diraviyam, additional, Varman, Surendra Doraiswamy, additional, Yeo, Andy Kuei Siong, additional, Elamin, Amal, additional, Chan, Angelique Wei-Ming, additional, and Matchar, David Bruce, additional

Published
2023
Full Text
View/download PDF

18. Pragmatic multicentre stepped-wedge cluster randomised trial to investigate the effectiveness of community-based falls prevention programme for older adults with falls risk in Singapore: a protocol paper

Author

Tan, Pey June, primary, Ginting, Mimaika Luluina, additional, Lim, Zoe Zon Be, additional, Balachandar, Nivedha, additional, Sultana, Rehena, additional, Kadir, Mumtaz Mohamed, additional, Xu, Tianma, additional, Ismail, Noor Hafizah, additional, Yap, Joyce Kwee Yong, additional, Wong, Sweet Fun, additional, Yoong, Joanne, additional, Matchar, David Bruce, additional, Hill, Keith, additional, and Wong, Chek Hooi, additional

Published
2023
Full Text
View/download PDF

19. Coronavirus disease 2019 (COVID-19): an evidence map of medical literature

Author

Liu, Nan, Chee, Marcel Lucas, Niu, Chenglin, Pek, Pin Pin, Siddiqui, Fahad Javaid, Ansah, John Pastor, Matchar, David Bruce, Lam, Sean Shao Wei, Abdullah, Hairil Rizal, Chan, Angelique, Malhotra, Rahul, Graves, Nicholas, Koh, Mariko Siyue, Yoon, Sungwon, Ho, Andrew Fu Wah, Ting, Daniel Shu Wei, Low, Jenny Guek Hong, and Ong, Marcus Eng Hock

Published
2020
Full Text
View/download PDF

27. Can acute clinical outcomes predict health-related quality of life after stroke: a one-year prospective study of stroke survivors

Author

Yeoh, Yen Shing, Koh, Gerald Choon-Huat, Tan, Chuen Seng, Lee, Kim En, Tu, Tian Ming, Singh, Rajinder, Chang, Hui Meng, De Silva, Deidre A., Ng, Yee Sien, Ang, Yan Hoon, Yap, Philip, Chew, Effie, Merchant, Reshma Aziz, Yeo, Tseng Tsai, Chou, Ning, Venketasubramanian, N., Young, Sherry H., Hoenig, Helen, Matchar, David Bruce, and Luo, Nan

Published
2018
Full Text
View/download PDF

29. Negative and positive experiences of caregiving among family caregivers of older blunt trauma patients

Author

Wong, Ting-Hway, primary, Tan, Timothy Xin Zhong, additional, Loo, Lynette Ma, additional, Chua, Wei Chong, additional, Iau, Philip Tsau Choong, additional, Ang, Arron Seng Hock, additional, Goo, Jerry Tiong Thye, additional, Chan, Kim Chai, additional, Nguyen, Hai V., additional, Nadkarni, Nivedita V., additional, Matchar, David Bruce, additional, Seow, Dennis Chuen Chai, additional, Ng, Yee Sien, additional, Chan, Angelique, additional, Fook-Chong, Stephanie, additional, Tang, Tjun Yip, additional, Ong, Marcus Eng Hock, additional, and Malhotra, Rahul, additional

Published
2022
Full Text
View/download PDF

44. Development and Assessment of an Interpretable Machine Learning Triage Tool for Estimating Mortality After Emergency Admissions

Author

Xie, Feng, primary, Ong, Marcus Eng Hock, additional, Liew, Johannes Nathaniel Min Hui, additional, Tan, Kenneth Boon Kiat, additional, Ho, Andrew Fu Wah, additional, Nadarajan, Gayathri Devi, additional, Low, Lian Leng, additional, Kwan, Yu Heng, additional, Goldstein, Benjamin Alan, additional, Matchar, David Bruce, additional, Chakraborty, Bibhas, additional, and Liu, Nan, additional

Published
2021
Full Text
View/download PDF

48. Frailty and length of stay in older adults with blunt injury in a national multicentre prospective cohort study

Author

Tan, Timothy Xin Zhong, primary, Nadkarni, Nivedita V., additional, Chua, Wei Chong, additional, Loo, Lynette Ma, additional, Iau, Philip Tsau Choong, additional, Ang, Arron Seng Hock, additional, Goo, Jerry Tiong Thye, additional, Chan, Kim Chai, additional, Malhotra, Rahul, additional, Ong, Marcus Eng Hock, additional, Matchar, David Bruce, additional, Seow, Dennis Chuen Chai, additional, Nguyen, Hai V., additional, Ng, Yee Sien, additional, Chan, Angelique, additional, and Wong, Ting-Hway, additional

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results