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35 results on '"Mathe, Domokos"'

10. Olive Oil Improves While Trans Fatty Acids Further Aggravate the Hypomethylation of LINE-1 Retrotransposon DNA in an Environmental Carcinogen Model

Author

Szabo, Laszlo, primary, Molnar, Richard, additional, Tomesz, Andras, additional, Deutsch, Arpad, additional, Darago, Richard, additional, Varjas, Timea, additional, Ritter, Zsombor, additional, Szentpeteri, Jozsef L., additional, Andreidesz, Kitti, additional, Mathe, Domokos, additional, Hegedüs, Imre, additional, Sik, Attila, additional, Budan, Ferenc, additional, and Kiss, Istvan, additional

Published
2022
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13. Anticancer Potential of L-Histidine-Capped Silver Nanoparticles against Human Cervical Cancer Cells (SiHA)

Author

Mohammed Asik, Rajmohamed, primary, Manikkaraja, Chidhambaram, additional, Tamil Surya, Karuppusamy, additional, Suganthy, Natarajan, additional, Priya Aarthy, Archunan, additional, Mathe, Domokos, additional, Sivakumar, Muthusamy, additional, Archunan, Govindaraju, additional, Padmanabhan, Parasuraman, additional, and Gulyas, Balazs, additional

Published
2021
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14. Folate-Targeted Monodisperse PEG-Based Conjugates Made by Chemo-Enzymatic Methods for Cancer Diagnosis and Treatment

Author

Nagy, Krisztina S., primary, Toth, Krisztina, additional, Pallinger, Eva, additional, Takacs, Angela, additional, Kohidai, Laszlo, additional, Jedlovszky-Hajdu, Angela, additional, Mathe, Domokos, additional, Kovacs, Noemi, additional, Veres, Daniel S., additional, Szigeti, Krisztian, additional, Molnar, Kristof, additional, Krisch, Eniko, additional, and Puskas, Judit E., additional

Published
2021
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18. Thrombocytosis and Effects of IL-6 Knock-Out in a Colitis-Associated Cancer Model

Author

Josa, Valeria, primary, Ferenczi, Szilamer, additional, Szalai, Rita, additional, Fuder, Eniko, additional, Kuti, Daniel, additional, Horvath, Krisztina, additional, Hegedus, Nikolett, additional, Kovacs, Tibor, additional, Bagamery, Gergo, additional, Juhasz, Balazs, additional, Winkler, Zsuzsanna, additional, Veres, Daniel S., additional, Zrubka, Zsombor, additional, Mathe, Domokos, additional, and Baranyai, Zsolt, additional

Published
2020
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21. Effect of 7,12-Dimethylbenz(α)anthracene on the Expression of miR-330, miR-29a, miR-9-1, miR-9-3 and the mTORC1 Gene in CBA/Ca Mice

Author

TOMESZ, ANDRAS, primary, SZABO, LASZLO, additional, MOLNAR, RICHARD, additional, DEUTSCH, ARPAD, additional, DARAGO, RICHARD, additional, MATHE, DOMOKOS, additional, BUDAN, FERENC, additional, GHODRATOLLAH, NOWRASTEH, additional, VARJAS, TIMEA, additional, NEMETH, BALAZS, additional, and KISS, ISTVAN, additional

Published
2020
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24. Engineering tyrosine residues into hemoglobin enhances heme reduction, decreases oxidative stress and increases vascular retention of a hemoglobin based blood substitute

Author

Cooper, Chris E., primary, Silkstone, Gary G.A., additional, Simons, Michelle, additional, Rajagopal, Badri, additional, Syrett, Natalie, additional, Shaik, Thoufieq, additional, Gretton, Svetlana, additional, Welbourn, Elizabeth, additional, Bülow, Leif, additional, Eriksson, Nélida Leiva, additional, Ronda, Luca, additional, Mozzarelli, Andrea, additional, Eke, Andras, additional, Mathe, Domokos, additional, and Reeder, Brandon J., additional

Published
2019
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25. Synthesis, Characterization, and Application of Core–Shell Co0.16Fe2.84O4@NaYF4(Yb, Er) and Fe3O4@NaYF4(Yb, Tm) Nanoparticle as Trimodal (MRI, PET/SPECT, and Optical) Imaging Agents

Author

Cui, Xianjin, primary, Mathe, Domokos, additional, Kovács, Noémi, additional, Horváth, Ildikó, additional, Jauregui-Osoro, Maite, additional, Torres Martin de Rosales, Rafael, additional, Mullen, Gregory E. D., additional, Wong, Wilson, additional, Yan, Yong, additional, Krüger, Dirk, additional, Khlobystov, Andrei N., additional, Gimenez-Lopez, Maria, additional, Semjeni, Mariann, additional, Szigeti, Krisztián, additional, Veres, Dániel S, additional, Lu, Haizhou, additional, Hernández, Ignacio, additional, Gillin, William P., additional, Protti, Andrea, additional, Petik, Katalin Kis, additional, Green, Mark A., additional, and Blower, Philip J., additional

Published
2015
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27. Synthesis, Characterization, and Application of Core-Shell Co0.16Fe2.84O4@NaYF4(Yb, Er) and Fe3O4@NaYF4(Yb, Tm) Nanoparticle as Trimodal (MRI, PET/SPECT, and Optical)...

Author

Xianjin Cui, Mathe, Domokos, Kovács, Noémi, Horváth, Ildikó, Jauregui-Osoro, Maite, de Rosales, Rafael Torres Martin, Mullen, Gregory E. D., Wilson Wong, Yong Yan, Krüger, Dirk, Khlobystov, Andrei N., Gimenez-Lopez, Maria, Semjeni, Mariann, Szigeti, Krisztián, Veres, Dániel S., Haizhou Lu, Hernández, Ignacio, Gillin, William P., Protti, Andrea, and Petik, Katalin Kis

Published
2016
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30. Automated material map generation from MRI scout pairs for preclinical PET attenuation correction.

Author

Bandi, Peter, Zsoter, Norbert, Koncz, Peter, Babos, Magor, Hobor, Sandor, Mathe, Domokos, and Papp, Laszlo

Abstract

A novel method is presented to perform material map segmentation from preclinical MRI for corresponding PET attenuation correction. MRI does not provide attenuation ratio, hence segmenting a material map from it is challenging. Furthermore the MRI images often suffer from ghost artifacts. On the contrary MRI has no radiation dose. Our method operated with fast spin echo scout pairs that had perpendicular frequency directions. This way the direction of the ghost artifacts were perpendicular as well. Our body-air segmentation method built on this a priori information and successfully erased the ghost artifacts from the final binary mask. Visual and quantitative validation was performed by two preclinical specialists. Results indicate that our method is effective against MRI scout ghost artifacts and that PET attenuation correction based on MRI makes sense even on preclinical images. [ABSTRACT FROM PUBLISHER]

Published
2012
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31. Usefulness of 99mTc(V)--dimercaptosuccinic acid scintigraphy in the assessment of response to external radiation therapy in soft tissue sarcoma in Giant Schnauzer dog.

Author

Chaudhari, Pradip R., Mathe, Domokos, Balogh, Lajos, Andocs, Gabor, and Janoki, Gyzo A.

Subjects
GIANT schnauzer, CANCER in animals, TUMORS in animals, DOG diseases, CANCER treatment
Abstract

A nine-year-old male black Giant Schnauzer dog was referred for the scintigraphic evaluation with a history of malignant fibrosarcoma with a rapidly growing non painful mass on the left shoulder region quite near to the site of an operation performed four months ago. We carried out oncological scintigraphy using pentavalent 99mTechnetium labelled dimercaptosuccinic acid [99mTc(V)-DMSA], a tumour localising radiopharmaceutical agent. The study was performed to assess the margins, vascularity of the tumour and response to the cancer therapy. Uniform intense radiopharmaceutical uptake was observed in the lesion indicating its margins, vascularity and malignant nature. The dog was subjected to external radiation therapy to control the growth of the cancer and to bring the tumour mass to an operable size. The dog was followed up with 99mTc(V)-DMSA scintigraphy pre-irradiation and post-irradiation. Immediately after the post-irradiation scintigraphy, the dog was operated on. During the surgery, resection of the tumour margins was performed carefully using a hand held gamma probe to assure that no tumour tissue was left inside. In conclusion, the authors would like to state that 99mTc(V)-DMSA oncoscintigraphy is valuable in the assessment and evaluation of therapy in canine soft tissue cancer. [ABSTRACT FROM AUTHOR]

Published
2005

32. Short-lived and extended half-life target modules for redirecting UniCAR T-cells against sialyl-Tn expressing cancer cells

Author

Loureiro, Liliana, Anja Feldmann, Bergmann, Ralf, Koristka, Stefanie, Berndt, Nicole, Hegedus, Nikolett, Mathe, Domokos, Videira, Paula, Bachmann, Michael, and Arndt, Claudia

Abstract

Background The development of chimeric antigen receptors (CARs) has rapidly emerged as a promising approach in cancer immunotherapy. Nonetheless, drawbacks associated with CAR T cell therapies include on-target/off-tumor effects and cytokine release syndrome. Aiming an increased clinical safety while preserving the efficacy of such therapy, we developed a novel modular universal CAR platform termed UniCAR. UniCAR T-cells are exclusively activated in the presence of a target module (TM), which establishes the cross-link between antigen-specific cancer cells and UniCAR T-cells in an individualized time- and target-dependent manner. The carbohydrate antigen sialyl-Tn (STn) is a particularly interesting target due to its expression in several types of cancer and absence in normal healthy tissues. Given the small size of such TMs, they are rapidly eliminated and thus, possible side effects and activation of UniCAR T-cells can be easily controlled by TM dosing. In late phases of treatment, TMs with extended half-life may play an important role by improving the eradication of residual tumor cells. Methods In this work, a novel longer-lasting TM against STn was developed, characterized and compared to the previously developed short-lived anti-STn TM. Short-lived TMs are composed of a tumor-specific binding moiety fused to the La peptide epitope (E5B9) which is recognized by UniCAR T-cells. In extended half-life TMs, these two components are fused via an Fc domain derived from the human IgG4 molecule. Functional and pharmacokinetic properties were assessed using in vitro and in vivo assays. Results The developed anti-STn IgG4-based TM efficiently activates and redirects UniCAR T-cells to STn-expressing tumors in a highly efficient target-specific and target-dependent manner, promoting the secretion of pro-inflammatory cytokines, tumor cell lysis of breast and bladder cancer cells in vitro and of breast cancer cells in experimental mice. A comparable or increased killing efficiency was obtained at a lower concentration range in comparison to the results obtained for the anti-STn scFv-based TM. Additionally, PET studies demonstrate the specific enrichment of the anti-STn IgG4-based TM at the tumor site presenting a prolonged serum half-life compared to the scFv short-lived TM. Conclusions Taken together, these data demonstrate the effective and potential application of this CAR T cell-derived modular system to target STn in different types of cancer using different TM formats. The use and combination of such molecules with different formats and half-lives provides highly promising and customized tools for retargeting of UniCAR T-cells in a flexible, individualized and safe manner at different stages of treatment.

33. Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging.

Author

Cui, Xianjin, Belo, Salome, Krüger, Dirk, Yan, Yong, de Rosales, Rafael T.M., Jauregui-Osoro, Maite, Ye, Haitao, Su, Shi, Mathe, Domokos, Kovács, Noémi, Horváth, Ildikó, Semjeni, Mariann, Sunassee, Kavitha, Szigeti, Krisztian, Green, Mark A., and Blower, Philip J.

Subjects
*ALUMINUM hydroxide, *MANGANESE compounds, *FERRIC oxide, *MAGNETIC resonance imaging, *POSITRON emission tomography, *IMAGE analysis
Abstract

Abstract: Magnetic nanoparticles (NPs) MnFe2O4 and Fe3O4 were stabilised by depositing an Al(OH)3 layer via a hydrolysis process. The particles displayed excellent colloidal stability in water and a high affinity to [18F]-fluoride and bisphosphonate groups. A high radiolabeling efficiency, 97% for 18F-fluoride and 100% for 64Cu-bisphosphonate conjugate, was achieved by simply incubating NPs with radioactivity solution at room temperature for 5 min. The properties of particles were strongly dependant on the thickness and hardness of the Al(OH)3 layer which could in turn be controlled by the hydrolysis method. The application of these Al(OH)3 coated magnetic NPs in molecular imaging has been further explored. The results demonstrated that these NPs are potential candidates as dual modal probes for MR and PET. In vivo PET imaging showed a slow release of 18F from NPs, but no sign of efflux of 64Cu. [Copyright &y& Elsevier]

Published
2014
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34. Synthesis, Characterization, and Application of Core-Shell Co0.16Fe2.84O4@NaYF4(Yb, Er) and Fe3O4@NaYF4(Yb, Tm) Nanoparticle as Trimodal (MRI, PET/SPECT, and Optical) Imaging Agents.

Author

Cui X, Mathe D, Kovács N, Horváth I, Jauregui-Osoro M, Torres Martin de Rosales R, Mullen GE, Wong W, Yan Y, Krüger D, Khlobystov AN, Gimenez-Lopez M, Semjeni M, Szigeti K, Veres DS, Lu H, Hernández I, Gillin WP, Protti A, Petik KK, Green MA, and Blower PJ

Subjects
Animals, Diphosphonates chemistry, Diphosphonates pharmacokinetics, Ferrosoferric Oxide pharmacokinetics, Fluorides pharmacokinetics, Male, Mice, Inbred C57BL, Mice, Nude, Multimodal Imaging methods, Polyethylene Glycols chemistry, Polyethylene Glycols pharmacokinetics, Tomography, Emission-Computed, Single-Photon methods, Yttrium pharmacokinetics, Ferrosoferric Oxide chemistry, Fluorides chemistry, Magnetic Resonance Imaging methods, Nanoparticles chemistry, Optical Imaging methods, Positron-Emission Tomography methods, Yttrium chemistry
Abstract

Multimodal nanoparticulate materials are described, offering magnetic, radionuclide, and fluorescent imaging capabilities to exploit the complementary advantages of magnetic resonance imaging (MRI), positron emission tomography/single-photon emission commuted tomography (PET/SPECT), and optical imaging. They comprise Fe3O4@NaYF4 core/shell nanoparticles (NPs) with different cation dopants in the shell or core, including Co0.16Fe2.84O4@NaYF4(Yb, Er) and Fe3O4@NaYF4(Yb, Tm). These NPs are stabilized by bisphosphonate polyethylene glycol conjugates (BP-PEG), and then show a high transverse relaxivity (r2) up to 326 mM(-1) s(-1) at 3T, a high affinity to [(18)F]-fluoride or radiometal-bisphosphonate conjugates (e.g., (64)Cu and (99m)Tc), and fluorescent emissions from 500 to 800 nm under excitation at 980 nm. The biodistribution of intravenously administered particles determined by PET/MR imaging suggests that negatively charged Co0.16Fe2.84O4@NaYF4(Yb, Er)-BP-PEG (10K) NPs cleared from the blood pool more slowly than positively charged NPs Fe3O4@NaYF4(Yb, Tm)-BP-PEG (2K). Preliminary results in sentinel lymph node imaging in mice indicate the advantages of multimodal imaging.

Published
2016
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35. Automated material map generation from MRI scout pairs for preclinical PET attenuation correction.

Author

Bandi P, Zsoter N, Koncz P, Babos M, Hobor S, Mathe D, and Papp L

Subjects
Automation, Magnetic Resonance Imaging, Positron-Emission Tomography
Abstract

A novel method is presented to perform material map segmentation from preclinical MRI for corresponding PET attenuation correction. MRI does not provide attenuation ratio, hence segmenting a material map from it is challenging. Furthermore the MRI images often suffer from ghost artifacts. On the contrary MRI has no radiation dose. Our method operated with fast spin echo scout pairs that had perpendicular frequency directions. This way the direction of the ghost artifacts were perpendicular as well. Our body-air segmentation method built on this a priori information and successfully erased the ghost artifacts from the final binary mask. Visual and quantitative validation was performed by two preclinical specialists. Results indicate that our method is effective against MRI scout ghost artifacts and that PET attenuation correction based on MRI makes sense even on preclinical images.

Published
2012
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