21 results on '"Mathew BC"'
Search Results
2. Neuroprotective Effects of Garlic: A Review
- Author
-
MATHEW BC and BIJU RS
- Subjects
garlic ,anti-atherogenic ,anti-oxidant ,anti-apoptotic ,neuroprotective ,Medicine - Abstract
Garlic has been investigated extensively for health benefits, resulting in more than one thousand publications over the last decade alone. It is considered one of the best disease preventive foods, based on its potent and varied effects. Midlife risk factors for cardiovascular diseases, such as high serum total cholesterol, raised LDL, increased LDL oxidation, increased platelet aggregation, impaired fibrinolysis, hypertension and homocystinemia are important risk factors for dementia in later years. These risk factors play a major role in the genesis of atherosclerosis of vital arteries causing both cardiovascular and cerebrovascular disease. Garlic is best known for its lipid lowering and anti-atherogenic effects. Possible mechanisms of action include inhibition of the hepatic activities of lipogenic and cholesterogenic enzymes that are thought to be the genesis for dyslipidemias, increased excretion of cholesterol and suppression of LDL-oxidation. Oxidative stress caused by increased accumulation of reactive oxygen species (ROS) in cells has been implicated in the pathophysiology of several neurodegenerative diseases including Alzheimer's disease (AD). Several studies have demonstrated the antioxidant properties of garlic and its different preparations including Aged Garlic Extract (AGE). AGE and S-allyl-cysteines (SAC), a bioactive and bioavailable component in garlic preparations have been shown in a number of in vitro studies to protect neuronal cells against beta-amyloid (A ) toxicity and apoptosis. Thus the broad range of anti-atherogenic, antioxidant and anti-apoptotic protection afforded by garlic may be extended to its neuroprotective action, helping to reduce the risk of dementia, including vascular dementia and AD.
- Published
- 2008
3. Quit Smoking and Run For Your Life!
- Author
-
Bordom J, Daniel RS, and Mathew BC
- Subjects
Medicine - Abstract
To The Editor: The World Health Organization promotes the World No Tobacco Day on May 31.
- Published
- 2008
4. Seasonal Variation In Cataract Surgery: A Myth or Reality?
- Author
-
Mankad S, Shah D, and Mathew Bc
- Subjects
business.industry ,medicine.medical_treatment ,Medicine ,Seasonality ,Cataract surgery ,business ,medicine.disease ,Demography - Published
- 2021
5. Protectors or Perpetrators
- Author
-
Bordom J, Ian W Campbell, Daniel Rs, and Mathew Bc
- Subjects
Economic growth ,Operations research ,Emergency management ,business.industry ,lcsh:R ,Health infrastructure ,World Health Day ,Global health issue ,lcsh:Medicine ,General Medicine ,World Health Organization ,World health ,Natural hazard ,Terrorism ,Correspondence ,Global health ,Wild Fires ,Medicine ,business ,Natural disaster - Abstract
To The Editor: World Health Day is celebrated globally every year on 7 April, to mark the Anniversary of the 1948 founding of the World Health Organization (WHO). The aim of celebrating this day every year is to raise awareness on a key global health issue. The theme of World Health Day 2009 is – “Save lives. Make hospitals safe in emergencies”, which focuses on the importance of investing in health infrastructure and that is able to withstand natural hazards, conflicts or a deteriorating situation and that is able to serve and protect people in immediate need [1]. Events around the world will highlight successes, campaign for safe facility design and construction, and build momentum for widespread emergency preparedness. Health facilities, large or small, urban or rural are critical life-lines to the community in case of emergencies and the safety of these centers become crucial in the successful management of any disaster [1]. They can be affected by natural calamities such as earthquakes, floods, hurricanes, landslides, volcanic eruptions, wild fires, avalanches, drought, and rock falls. Man-made events such as fires, gas leaks, explosions and terrorist attacks can also destroy them [2].
- Published
- 2009
6. Swine- Origin Influenza A (H1N1) Pandemic Revisited
- Author
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Mathew Bc, Ian W Campbell, and RS Daniel
- Subjects
Oseltamivir ,medicine.medical_specialty ,business.industry ,medicine.drug_class ,virus diseases ,Outbreak ,Influenza a ,General Medicine ,medicine.disease_cause ,Virology ,Virus ,Special Article ,chemistry.chemical_compound ,chemistry ,Epidemiology ,Influenza A virus ,medicine ,Human mortality from H5N1 ,Antiviral drug ,business - Abstract
Since the beginning of January 2008 sporadic cases of infections in humans caused by influenza A (H1N1) virus- resistant to available anti-influenza drugs have been reported worldwide [1,2]. The World Health Organization (WHO) in its report published on 18 March 2009 indicated that during weeks 1- 4 (28 December 08-24 January 09), the level of overall influenza activity in the world increased. During this period, 1291 of 1362 A (H1N1) cases from 30 countries showed resistance to the antiviral drug osaltamivir. [3]. In Canada, United States of America, Japan, Republic of Korea, Hong Kong, France, Germany, Ireland, Sweden and United Kingdom the prevalence of oseltamivir resistance was reported to be more than 95% [3]. On 24 April WHO released the first alert indicating the occurrence of confirmed human cases of swine influenza (H1N1) in Mexico and the United States [4]. Subsequently the Centre for Disease Control and Prevention (CDC), in the United States confirmed that these human influenza cases were caused by a new strain of influenza A virus subtype (H1N1) [5].
- Published
- 2009
7. Kudos to The Virus Hunters
- Author
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Mathew Bc, Daniel Rs, and Bordom J
- Subjects
medicine.medical_specialty ,Human Papilloma Virus Vaccine ,Epidemic ,lcsh:Medicine ,Human papilloma virus ,Libya ,HPV vaccines ,Genital warts ,Acquired immunodeficiency syndrome (AIDS) ,Correspondence ,medicine ,Cervical cancer ,business.industry ,Gardasil ,lcsh:R ,HPV infection ,HIV ,virus diseases ,General Medicine ,medicine.disease ,Virology ,humanities ,AIDS ,Family medicine ,Cervarix ,business ,medicine.drug - Abstract
To The Editor: On 6th October the Nobel Assembly at Karolinska Institute, Stockholm, Sweden announced The Nobel Prize in Physiology or Medicine for 2008, and virologists all over the world had a lot to cheer about. Three “virus hunters” who worked with two different viruses brought honour to virology. Harald zur Hausen for his discovery of “human papilloma viruses (HPV) causing cervical cancer” and Francoise Barre-Sinoussi and Luc Montagnier for their discovery of “human immunodeficiency virus (HIV)” have been chosen for this year's award [1]. All three will deliver the Nobel Lectures on Sunday 7th December. The entire scientific community is waiting to hear about their encounters, relentless battles, and exploits against these pathogens. Their discoveries have paved the way for an astonishing progress in preventing HPV induced cervical cancer, and more zeal to find a successful vaccine against the HIV. Nobel prizes can be split between a maximum of three individuals and it indeed is a great irony that a stalwart like Robert Gallo, the “co-discoverer” of HIV had to be left out on technical or other reasons best known to the Nobel Committee. The Franco-American virus war between Luc Montaigner and Robert Gallo which started in 1984 and ended in 1987 is now part of scientific folklore. It is now known that the “French” lymphadenopathy associated virus (LAV) and “American” human T-cell leukemia /lymphoma virus type III B ( HTLV-IIIB) were indeed one and the same, which is now known as HIV. Many among the scientific community, and foe turned friend Luc Montaigner himself, acknowledged that Robert Gallo deserved to be the third recipient, had the Nobel Committee honoured only those who contributed to the discovery of HIV [2]. About half a century ago when there was considerable scepticism whether viruses cause cancer, Harald zur Hausen postulated a role for oncogenic human papilloma virus ( HPV) in cervical carcinoma. In 1983 he first identified HPA-DNA in cervix cancer biopsies, and thus the new, tumorigenic HPV16. In 1984 he cloned HPV16 and 18 and thus made these viruses available to the scientific community. His pioneering work demonstrated novel properties of HPV that lead to an understanding of mechanisms for papilloma virus- induced carcinogenesis and predisposing factors for viral persistence and cellular transformation [3]. HPV infection causes >550,000 cases of cervical and anogenital cancer worldwide annually, and is responsible for 99.7% of cervical cancer cases and an estimated 5% of all cancers worldwide [4, 5]. Of the more than 100 HPV types known, HPV 16 and HPV 18 are responsible for approximately 70% of all invasive cervical cancers worldwide, and HPV types 6 and 11 cause approximately 90% of cases of genital warts [4, 6]. The development of the human papilloma virus vaccine is a major milestone in the development of cancer vaccines. Following the success of several clinical trials, pharmaceutical giant Merck in 2006 submitted a successful Biologics License Application for its prophylactic HPV virus like particle (VLP) vaccine Gardasil TM to the US Food and Drug Administration. Subsequently, Gardasil TM received a European license, and many other countries also permitted its licensing. This vaccine for girls and women aged 9–26 years, protect against HPV types 6/11/16/18. The second prophylactic HPV vaccine Cervarix TM, manufactured by GlaxoSmithKline against HPV types 16 and 18 has been licensed this year [6]. A recent systematic review of randomized controlled trials of prophylactic HPV vaccination have indicated that among women aged 15–25 years not previously infected with vaccine type HPV strains, prophylactic HPV vaccination was 96%–100% effective in preventing HPV 6/11/16/18-related cervical and anogenital precancers and genital warts [7]. Despite the remarkable promise of the current prophylactic HPV vaccines, their introduction into developing countries will present unique and considerable challenges. These include lack of national data on type- specific HPV incidence, poor public awareness and attitudes toward HPV vaccination, complexities of vaccine introduction, and sociocultural issues related to HPV vaccines. A recent study in the United Kingdom to assess public knowledge about HPV and cervical cancer indicated that even in this developed country, the majority of participants had no knowledge about the problem or benefits of the vaccine [8]. A multifaceted and coordinated strategy would be needed to increase awareness and implementation of HPV vaccination programmes. Several international organizations such as PATH, International Agency for Research on Cancer, World Health Organization (WHO) and the Bill and Melinda Gates Foundation are playing an active role in introducing HPV vaccines in developing countries The history of AIDS is a short one, but the consequences of the global AIDS epidemic has been nothing less than catastrophic. Since its first description in the 1980s among homosexual men in San Fransisco, USA, 25 million have fallen victim to the deadly virus, and millions are living with the HIV infection worldwide [9]. Table 1 indicates the latest statistics on the world epidemic of AIDS and HIV which were published by UNAIDS/ WHO in July 2008, and refer to the end of 2007 [10]. Regional statistics for HIV and AIDS show that among the global total of 33 million adults and children living with HIV/AIDS, 22 million were in Sub-Saharan Africa. In three southern African countries national adult HIV prevalence rate now exceeds 20%. These countries are Botswana (23.9%), Lesotho (23.2%) and Swaziland (26.1%). A national survey conducted in 2004–2005 with 67,711 participants randomly recruited from across Libya showed that HIV prevalence among the general population had reached 0.67% in Alkoufra governorate in the south-east of the country, 0.4% in Tripoli compared with national prevalence of 0.13% [11]. Unlike the tremendous success achieved in developing the prophylactic vaccine against HPV, we are no nearer a cure and certainly years away from a vaccine against HIV [12]. Cost effective interventions such as male and female condom promotion, sex worker interventions, AIDS education in schools, voluntary counseling and testing, blood supply safety measures, encouraging partner reduction, and prevention of mother-to-child transmission can play a major role in containing the spread of this epidemic. The World AIDS day is observed every year on December 1st. The World Health Organization established World AIDS Day in 1988. The twentieth anniversary this year is another reminder for all of us to collectively work to raise awareness and focus attention on the global AIDS epidemic. From the bottom of our hearts let us thank the “virus hunters” for their great service to humanity and hope that their tribe grows to conquer these deadly pathogens. Table 1 Global HIV/AIDS estimates, end of 2007
- Published
- 2009
8. Neuroprotective Effects of Garlic A Review
- Author
-
Biju Rs and Mathew Bc
- Subjects
Antioxidant ,anti-atherogenic ,medicine.medical_treatment ,lcsh:Medicine ,Review Article ,Pharmacology ,medicine.disease_cause ,Neuroprotection ,chemistry.chemical_compound ,garlic ,medicine ,Dementia ,anti-apoptotic ,Vascular dementia ,chemistry.chemical_classification ,Reactive oxygen species ,Cholesterol ,business.industry ,anti-oxidant ,lcsh:R ,food and beverages ,neuroprotective ,General Medicine ,medicine.disease ,chemistry ,Toxicity ,business ,Oxidative stress - Abstract
Garlic has been investigated extensively for health benefits, resulting in more than one thousand publications over the last decade alone. It is considered one of the best disease preventive foods, based on its potent and varied effects. Midlife risk factors for cardiovascular diseases, such as high serum total cholesterol, raised LDL, increased LDL oxidation, increased platelet aggregation, impaired fibrinolysis, hypertension and homocystinemia are important risk factors for dementia in later years. These risk factors play a major role in the genesis of atherosclerosis of vital arteries causing both cardiovascular and cerebrovascular disease. Garlic is best known for its lipid lowering and anti-atherogenic effects. Possible mechanisms of action include inhibition of the hepatic activities of lipogenic and cholesterogenic enzymes that are thought to be the genesis for dyslipidemias, increased excretion of cholesterol and suppression of LDL-oxidation. Oxidative stress caused by increased accumulation of reactive oxygen species (ROS) in cells has been implicated in the pathophysiology of several neurodegenerative diseases including Alzheimer's disease (AD). Several studies have demonstrated the antioxidant properties of garlic and its different preparations including Aged Garlic Extract (AGE). AGE and S-allyl-cysteines (SAC), a bioactive and bioavailable component in garlic preparations have been shown in a number of in vitro studies to protect neuronal cells against beta-amyloid (A ) toxicity and apoptosis. Thus the broad range of anti-atherogenic, antioxidant and anti-apoptotic protection afforded by garlic may be extended to its neuroprotective action, helping to reduce the risk of dementia, including vascular dementia and AD. Key words: garlic, anti-atherogenic, anti-oxidant, anti-apoptotic, neuroprotective
- Published
- 2008
9. Protectors or Perpetrators
- Author
-
Mathew, BC, primary, Daniel, RS, additional, Bordom, JA, additional, and Campbell, IW, additional
- Published
- 2009
- Full Text
- View/download PDF
10. CHOLESTEROL: A CENTURY OF RESEARCH AND DEBATE
- Author
-
Mathew, BC, primary and Daniel, RS, additional
- Published
- 2008
- Full Text
- View/download PDF
11. Quit Smoking and Run For Your Life!
- Author
-
Mathew, BC, primary, Daniel, RS, additional, and Bordom, J, additional
- Published
- 2008
- Full Text
- View/download PDF
12. Assessment of intraocular pressure measurement between Goldman applanation tonometer, rebound tonometer, non-contact tonometer, and its correlation with central corneal thickness.
- Author
-
Porwal AC, Shrishrimal M, Punamia RP, and Mathew BC
- Subjects
- Humans, Cross-Sectional Studies, Prospective Studies, Cornea, Reproducibility of Results, Intraocular Pressure, Tonometry, Ocular methods
- Abstract
Purpose: To compare readings of intraocular pressure (IOP) taken with the Goldmann applanation tonometer (GAT), the non-contact tonometer (NCT), and the rebound tonometer (RBT), and to compare their correlation with central corneal thickness (CCT)., Methods: This was a prospective, cross-sectional, observational study to which patients above 18 years of age were enrolled. A total of 400 eyes of 200 non-glaucomatous patients underwent IOP recordings using the GAT, NCT, and RBT, and CCT was also noted. Informed consent of the patients was taken. The IOP readings taken via the three methods were compared and correlated with CCT. Paired t test was used to compare the two devices. Simple and multivariate linear regression analyses were used to study the relationship between factors. A P value less than 0.05 was considered significant. Correlation was determined using the Pearson correlation coefficient, and a Bland-Altman graph was plotted., Results: Mean IOP measured by the NCT was 15.65 ± 2.80 mmHg, by the RBT was 14.23 ± 3.05 mmHg, and by the GAT was 14.69 ± 2.97 mmHg. The mean CCT was 510.61 ± 33.83 microns. The difference between mean IOP recorded by the NCT and that by the RBT was 1.41 ± 2.39 mmHg, between the NCT and GAT was 0.95 ± 2.03 mmHg, and between the GAT and RBT was 0.45 ± 2.22 mmHg. The difference between the IOP values was statistically significant (P < 0.005). All tonometers showed a statistically significant correlation with CCT, but it was observed that the NCT had a stronger correlation (0.4037)., Conclusion: The IOP readings taken by all the three methods were comparable; however, RBT values were closer to GAT values. CCT did influence the IOP values, and this should be kept in mind while evaluating., Competing Interests: None
- Published
- 2023
- Full Text
- View/download PDF
13. Surgeon fatigue: A factor in intraoperative complications in high volume tertiary eye care center.
- Author
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Porwal AC, Mathew BC, and Abhishek P
- Subjects
- Humans, Postoperative Complications, Tertiary Care Centers, Intraoperative Complications, Surgeons
- Abstract
Competing Interests: None
- Published
- 2021
- Full Text
- View/download PDF
14. Incidence of postoperative endophthalmitis with and without use of intracameral moxifloxacin.
- Author
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Porwal AC, Patel A, Mathew BC, and Jethani JN
- Subjects
- Anterior Chamber, Anti-Bacterial Agents therapeutic use, Cefuroxime, Fluoroquinolones adverse effects, Humans, Incidence, Moxifloxacin adverse effects, Postoperative Complications drug therapy, Postoperative Complications epidemiology, Cataract Extraction, Endophthalmitis diagnosis, Endophthalmitis epidemiology, Endophthalmitis etiology, Eye Infections, Bacterial diagnosis, Eye Infections, Bacterial drug therapy, Eye Infections, Bacterial epidemiology
- Abstract
Competing Interests: None
- Published
- 2021
- Full Text
- View/download PDF
15. An overview of electrochemiluminescent (ECL) technology in laboratory investigations.
- Author
-
Mathew BC, Biju RS, and Thapalia N
- Subjects
- Humans, Nepal, Immunoassay methods, Luminescent Measurements methods
- Published
- 2005
16. Cholesterol-lowering effect of organosulphur compounds from garlic: a possible mechanism of action.
- Author
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Mathew BC, Prasad NV, and Prabodh R
- Subjects
- Cholesterol biosynthesis, Garlic chemistry, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors isolation & purification, Hyperlipidemias drug therapy, Sulfhydryl Compounds isolation & purification, Sulfhydryl Compounds therapeutic use, Hydroxymethylglutaryl-CoA Reductase Inhibitors chemistry, Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use, Sulfhydryl Compounds chemistry
- Abstract
Objectives: Hyperlipidemia constitutes a major etiopathological factor for atherosclerosis. The medicinal value of garlic is best known for its lipid lowering effects and antiatherogenic effects. The mechanism by which lipid soluble organosulphur compounds from garlic reduce plasma lipids has not been fully investigated. The author had previously shown that the hepatic activity of beta-hydroxy-beta-methylglutaryl-CoA (HMG-CoA) reductase, the rate limiting enzyme in cholesterol biosynthesis and the incorporation of radiolabeled (1, 2 14C), acetate into hepatic free and esterified cholesterol was significantly decreased in rat treated with garlic derived organosulphur compounds. We hypothesised that the antiatherogenic effect of the organosulphur compounds may be attributed to the formation of protein internal disulphide and thus inactivation of thiol (-SH) group enzymes such as HMG-CoA reductase and the multienzyme complex of fatty acid synthesis. The objective of the present study is to elucidate the inhibitory mechanism by in vitro studies., Method: Lipid soluble organosulphur compounds from garlic were treated in vitro with Luke's cysteine reagent (representing the thiol (-SH) group of enzymes) and the interaction products were separated by paper chromatography., Result: The result indicated that the organosulphur compounds were capable of interacting with the thiol (-SH) group of cysteine and thus forming cysteine derivatives., Conclusion: The antiatherogenic effects of these organosulphur compounds can be attributed to such reactions that inhibit HMG-CoA reductase and other lipogenic enzymes. The anticarcinogenic effects of these compounds may also be due to inhibitory reactions on enzymes that activate carcinogens.
- Published
- 2004
17. Antioxidant effect of two flavonoids from the bark of Ficus bengalensis Linn in hyperlipidemic rats.
- Author
-
Daniel RS, Mathew BC, Devi KS, and Augusti KT
- Subjects
- Animals, Antioxidants isolation & purification, Antioxidants metabolism, Cellobiose isolation & purification, Cellobiose pharmacology, Chromans isolation & purification, Flavonoids isolation & purification, Hyperlipidemias drug therapy, Hyperlipidemias metabolism, Lipid Peroxidation drug effects, Male, Mannosides isolation & purification, Quercetin pharmacology, Rats, Rats, Sprague-Dawley, Rosales chemistry, Trees chemistry, Anthocyanins, Antioxidants pharmacology, Cellobiose analogs & derivatives, Chromans pharmacology, Flavonoids pharmacology, Mannosides pharmacology
- Abstract
Two flavonoid compounds, viz. 5,7-dimethyl ether of leucopelargonidin 3-0-alpha-L rhamnoside and 5,3'-dimethyl ether of leucocyanidin 3-0-alpha-D galactosyl cellobioside obtained from the bark of F. bengalensis were evaluated for their antioxidant action in hyperlipidemic rats. The results were compared with the activity of a structurally similar flavonoid, quercetin, a known antioxidant. The Ficus compounds showed significant antioxidant effects which may be attributed to their polyphenolic nature. The methylation of two hydrozyl groups in the Ficus flavonoids might have slowed down their antioxidant action as compared to quercetin.
- Published
- 1998
18. Biochemical effects of garlic protein diet and garlic oil on glycosaminoglycan metabolism in cholesterol fed rats.
- Author
-
Mathew BC and Augusti KT
- Subjects
- Animals, Male, Rats, Rats, Sprague-Dawley, Allyl Compounds, Cholesterol, Dietary adverse effects, Garlic, Glycosaminoglycans metabolism, Plant Oils pharmacology, Plant Proteins pharmacology, Plants, Medicinal, Sulfides pharmacology
- Abstract
Garlic protein diet or daily administration of garlic oil to 2% cholesterol fed rats controlled significantly the increases in sulphated glycosaminoglycans in their heart and aorta. However hyaluronic acid level increased. UDPG dehydrogenase decreased and several degrading enzymes increased in the aorta on treatment. The effects of treatment were just the reverse in liver. The high percentage of cysteine in garlic protein and the reactive disulphide group in the oil may be responsible for their beneficial effects.
- Published
- 1996
19. Hypolipidemic effect of garlic protein substituted for casein in diet of rats compared to those of garlic oil.
- Author
-
Mathew BC, Daniel RS, and Augusti KT
- Subjects
- Animals, Male, Rats, Rats, Sprague-Dawley, Allyl Compounds, Diet, Garlic chemistry, Lipids blood, Plant Oils pharmacology, Plant Proteins pharmacology, Plants, Medicinal, Sulfides pharmacology
- Abstract
Garlic (Allium sativum Linn.) is ascribed with many therapeutic effects. For the present study, the water soluble proteins and the essential oil of garlic were investigated for their hypolipidemic effect on hyperlipidemia induced by cholesterol containing diet in albino rats. Both garlic protein (16% of diet) and garlic oil (100 mg/kg body weight/day) exhibited significant lipid lowering effects. The hypolipidemic action is primarily due to a decrease in hepatic cholesterogenesis in the treated rats. Even though garlic oil was found to be more effective, the garlic protein is more palatable and free from an obnoxious smell.
- Published
- 1996
20. Antidiabetic and hypolipidemic effects of S-methyl cysteine sulfoxide isolated from Allium cepa Linn.
- Author
-
Kumari K, Mathew BC, and Augusti KT
- Subjects
- Animals, Cysteine isolation & purification, Cysteine pharmacology, Male, Rats, Rats, Sprague-Dawley, Allium chemistry, Cysteine analogs & derivatives, Diabetes Mellitus, Experimental drug therapy, Hypoglycemic Agents pharmacology, Hypolipidemic Agents pharmacology
- Abstract
S-methyl cysteine sulphoxide (SMCS), a sulphur containing amino acid isolated from onion (Allium cepa Linn) showed antidiabetic and antihyperlipidemic effects. Oral administration of SMCS daily at a dose of 200 mg/kg body weight for a period of 45 days to alloxan diabetic rats controlled significantly their blood glucose and lipids in serum and tissues and altered the activities of liver hexokinase, glucose 6-phosphatase and HMG CoA reductase towards normal. The above effects of SMCS were comparable to those of glibenclamide and insulin.
- Published
- 1995
21. Hypoglycemic effects of leucodelphinidin derivative isolated from Ficus bengalensis (Linn).
- Author
-
Geetha BS, Mathew BC, and Augusti KT
- Subjects
- Animals, Blood Glucose drug effects, Blood Glucose metabolism, Flavonoids isolation & purification, Flavonoids therapeutic use, Glucose Tolerance Test, Glyburide therapeutic use, Plant Extracts therapeutic use, Rats, Diabetes Mellitus, Experimental drug therapy, Flavonoids pharmacology, Glyburide pharmacology, Hypoglycemia chemically induced, Plant Extracts pharmacology
- Abstract
A Leucodelphinidin derivative isolated from the bark of Ficus bengalensis Linn demonstrated hypoglycemic action at a dosage of 250 mg/kg given both in normal and alloxan diabetic rats. It's action is closely similar to that of an effective dose of glibenclamide (2 mg/kg) tested under the same conditions. However, after a glucose load the plant product is only just significantly active but not as effective as the sulphonylurea. The efficacy of the plant product as a hydroglycemic agent adds to its other therapeutic effects, as it belongs to the class of flavonoids.
- Published
- 1994
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