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3. Session 18 Crop physiology

Author

Cochrane, M. P., Duffus, C. M., Debrunner, N., Feller, U., Dedov, A. V., De Visser, R., Vianden, H., Schnyder, H., Ehrenbergerová, J., DítĚtová, J., Feller, U., Hölzer, R., Gebbing, T., Schnyder, H., KÜhbauch, W., Gniazdowska-Skoczek, H., Surma, M., Adamski, T., Goubitz, S., Van Den Boogaard, R., Veneklaas, E., Grigortschuk, A. P., Hiller, L. K., Horák, J., Fojtík, A., JanáČek, J., MoČová, Š., ZámeČník, J., Kamínek, M., TrČková, M., Motyka, V., Gaudinová, A., Kervinen, J., TÖrmÄkangas, K., Runeberg-Roos, P., Gal, S., Kovaleva, V., Raikhel, N., Teeri, T. H., Kiriziy, D. A., Leja, M., Locher, R., Bucheli, P., Majidi, E. H., Fooman, A. A., Marx, S., Meyer, I., Macinnes, W. M., Schlienger, C., Bucheli, P., Nikolenko, V. F., Alexeeva, D. I., Novák, V., DvoŘák, M., Kumar, Y., Orthen, B., Popp, M., Ottosen C. -O., Mentz J., Prášil, I., Prioul, J. L., Rocher, J. P., Causse, M., De Vienne, D., Quarrie, S. A., Steed, A., Lebreton, C., Lazic-Jancic, V., Pekic, S., Santos, ConceiçĀo V., Caldeira, Gustavo, Štajner, D., GaŠič, O., Matkovics, B., Varga, Sz. I., Mimica-Dukić, N., Popovič, M., Touraine, B., Veneklaas, E. J., Kreulen, R., Van Den Boogaard, H. A. G. M., Lambers, H., Peacock, J. M., Warringa, J. W., Marinissen, M. J., ZámeČník, J., and Bieblova, J.

Published
1994
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47. Involvement of oxygen-derived free radicals in L-arginine-induced acute pancreatitis.

Author

Czakó, L, Takács, T, Varga, I S, Tiszlavicz, L, Hai, D Q, Hegyi, P, Matkovics, B, and Lonovics, J

Subjects
REACTIVE oxygen species, ANIMAL experimentation, ARGININE, FREE radicals, OXIDOREDUCTASES, PANCREAS, PANCREATITIS, RATS, SUPEROXIDE dismutase, MALONDIALDEHYDE, ACUTE diseases, ALLOPURINOL, CHEMICAL inhibitors, PHARMACODYNAMICS
Abstract

This study was aimed at an assessment of the role of oxygen-derived free radicals in the pathogenesis of L-arginine (Arg)-induced acute pancreatitis in rat, by measuring the levels of malonyl dialdehyde (MDA), glutathione peroxidase (GPx), catalase, and superoxide dismutase (Mn- and Cu,Zn-SOD) in the pancreatic tissue, and evaluating the protective effect of the xanthine oxidase inhibitor allopurinol. Acute pancreatitis was induced in male Wistar rats by injecting 2 x 250 mg/100 g body weight of Arg intraperitoneally in a 1-hr interval, as a 20% solution in 0.15 M NaCl. Control rats received the same quantity of glycine. Allopurinol, 100 or 200 mg/kg, was administered subcutaneously 30 min before the first Arg injection. Rats were killed at 6, 12, 24, and 48 hr following Arg administration, and acute pancreatitis was confirmed by a serum amylase level elevation and typical inflammatory features observed microscopically. The serum level of amylase reached the peak level at 24 hr after the Arg injection (30,800+/-3813 vs 6382+/-184 units/liter in the control) and normalized at 48 hr. The tissue concentration of MDA was significantly elevated at 24 hr and reached the peak value at 48 hr (5.00+/-1.75 vs 0.28+/-0.05 nM/mg protein in the control). The catalase and Mn-SOD activities were significantly decreased throughout the study, while the GPx activity was significantly reduced at 6 and 12 hr, and the Cu,Zn-SOD activity was significantly lower at 12 hr after the Arg injection as compared with the controls. Allopurinol treatment markedly reduced the serum amylase elevation (12.631+/-2.257 units/liter at 24 hr) and prevented the increase in tissue MDA concentration (0.55+/-0.09 nM/mg protein at 48 hr). Both doses of allopurinol significantly ameliorated the pancreatic edema, necrosis, and inflammation at 48 hr after Arg administration. Oxygen-derived free radicals are generated at an early stage of Arg-induced acute pancreatitis. Prophylactic allopurinol treatment prevents the generation of reactive oxygen metabolites, reduces the serum amylase concentration, and exerts a beneficial effect on the development of histopathological changes. [ABSTRACT FROM AUTHOR]

Published
1998

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