1. Association of variability in antibody binding affinity with a clinical course of anti-MAG neuropathy.
- Author
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Matsui, Taro, Hamada, Yukihiro, Kuwahara, Motoi, Morise, Jyoji, Oka, Shogo, Kaida, Kenichi, and Kusunoki, Susumu
- Subjects
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DISEASE progression , *IMMUNOGLOBULINS , *GLYCOCONJUGATES , *NEUROPATHY - Abstract
Anti-myelin-associated glycoprotein (MAG) neuropathy is mediated by the binding of IgM M-proteins to the human natural killer-1 epitope of several glycoconjugates, including MAG and phosphacan. We recently reported that IgM M-proteins with a higher ratio of anti-phosphacan titer to anti-MAG titer (P/M ratio) were associated with a progressive clinical course. Herein, we investigated the temporal variability of the P/M ratio. The results showed that P/M ratios in worsened cases were significantly increased relative to stable or improved cases. Thus, temporal variability in the specificity of IgM M-proteins may be related to the disease course of anti-MAG neuropathy. Unlabelled Image • Δ P/M ratios are higher in a worsened patients than improve or stable patients. • ΔP/M ratios are correlated to ΔINCAT scores. • P/M ratios may be useful as a novel biomarker of anti-MAG neuropathy. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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