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661 results on '"Matsuki, N."'

3. Oxygen supersaturated fluid using fine micro/nanobubbles

Author

Matsuki N, Ishikawa T, Ichiba S, Shiba N, Ujike Y, and Yamaguchi T

Subjects
Medicine (General), R5-920
Abstract

Noriaki Matsuki,1 Takuji Ishikawa,2 Shingo Ichiba,3 Naoki Shiba,3 Yoshihito Ujike,3 Takami Yamaguchi4 1Department of Biomedical Engineering, Graduate School of Engineering, Okayama University of Science, Okayama, 2Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, Sendai, 3Department of Emergency and Critical Care Medicine, Okayama University Hospital, Okayama, 4Graduate School of Biomedical Engineering, Tohoku University, Sendai, JapanAbstract: Microbubbles show peculiar properties, such as shrinking collapse, long lifetime, high gas solubility, negative electric charge, and free radical production. Fluids supersaturated with various gases can be easily generated using microbubbles. Oxygen microbubble fluid can be very useful for oxygen delivery to hypoxic tissues. However, there have been no reports of comparative investigations into adding fluids containing oxygen fine micro/nanobubbles (OFMNBs) to common infusion solutions in daily medical care. In this study, it was demonstrated that OFMNBs can generate oxygen-supersaturated fluids, and they may be sufficiently small to infuse safely into blood vessels. It was found that normal saline solution is preferable for generating an oxygen-rich infusion fluid, which is best administered as a 30-minute intravenous infusion. It was also concluded that dextran solution is suitable for drug delivery substances packing oxygen gas over a 1-hour intravenous infusion. In addition, normal saline solution containing OFMNBs was effective for improving blood oxygenation. Thus, the use of OFMNB-containing fluids is a potentially effective novel method for improving blood oxygenation in cases involving hypoxia, ischemic diseases, infection control, and anticancer chemoradiation therapies.Keywords: microbubble, fine micro/nanobubble, nanobubble, oxygenation, fluid oxygenation

Published
2014

21. Cover Image, Volume 16, Issue 3

Author

Sakai, K., primary, Maeda, S., additional, Yamada, Y., additional, Chambers, J. K., additional, Uchida, K., additional, Nakayama, H., additional, Yonezawa, T., additional, and Matsuki, N., additional

Published
2018
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25. Particle-Based Methods for Multiscale Modeling of Blood Flow in the Circulation and in Devices: Challenges and Future Directions

Author

Yamaguchi, T., Ishikawa, T., Imai, Y., Matsuki, N., Xenos, M., Deng, Y. F., and Bluestein, D.

Subjects
computer-simulation, boundary-conditions, von-willebrand-factor, dpd, clotting, element-method, multiscale modeling, parallel molecular-dynamics, numerical-simulation, particle dynamics, cell motion, capillary vessels, transport processes, numerical methods, platelets, blood flow, devices, porous-media
Abstract

A major computational challenge for a multiscale modeling is the coupling of disparate length and timescales between molecular mechanics and macroscopic transport, spanning the spatial and temporal scales characterizing the complex processes taking place in flow-induced blood clotting. Flow and pressure effects on a cell-like platelet can be well represented by a continuum mechanics model down to the order of the micrometer level. However, the molecular effects of adhesion/aggregation bonds are on the order of nanometer. A successful multiscale model of platelet response to flow stresses in devices and the ensuing clotting responses should be able to characterize the clotting reactions and their interactions with the flow. This paper attempts to describe a few of the computational methods that were developed in recent years and became available to researchers in the field. They differ from traditional approaches that dominate the field by expanding on prevailing continuum-based approaches, or by completely departing from them, yielding an expanding toolkit that may facilitate further elucidation of the underlying mechanisms of blood flow and the cellular response to it. We offer a paradigm shift by adopting a multidisciplinary approach with fluid dynamics simulations coupled to biophysical and biochemical transport. Ann Biomed Eng

Published
2010

27. Another view of T cell antigen recognition: cooperative engagement of glycolipid antigens by Va14Ja18 natural T(iNKT) cell receptor [corrected]

Author

Stanic, A, Shashidharamurthy, R, Bezbradica, J, Matsuki, N, Yoshimura, Y, Miyake, S, Choi, E, Schell, T, Van Kaer, L, Tevethia, S, Roopenian, D, Yamamura, T, and Joyce, S

Subjects
Receptors, Antigen, T-Cell, alpha-beta, Galactosylceramides, Mice, Transgenic, Cytotoxicity Tests, Immunologic, Lymphocyte Activation, Sensitivity and Specificity, Cell Line, Clone Cells, Antigens, CD1, Killer Cells, Natural, Mice, Inbred C57BL, Kinetics, Mice, Structure-Activity Relationship, Sphingosine, T-Lymphocyte Subsets, Animals, Antigens, Antigens, CD1d
Abstract

Va14Ja18 natural T (iNKT) cells rapidly elicit a robust effector response to different glycolipid Ags, with distinct functional outcomes. Biochemical parameters controlling iNKT cell function are partly defined. However, the impact of iNKT cell receptor beta-chain repertoire and how alpha-galactosylceramide (alpha-GalCer) analogues induce distinct functional responses have remained elusive. Using altered glycolipid ligands, we discovered that the Vb repertoire of iNKT cells impacts recognition and Ag avidity, and that stimulation with suboptimal avidity Ag results in preferential expansion of high-affinity iNKT cells. iNKT cell proliferation and cytokine secretion, which correlate with iNKT cell receptor down-regulation, are induced within narrow biochemical thresholds. Multimers of CD1d1-alphaGalCer- and alphaGalCer analogue-loaded complexes demonstrate cooperative engagement of the Va14Ja18 iNKT cell receptor whose structure and/or organization appear distinct from conventional alphabeta TCR. Our findings demonstrate that iNKT cell functions are controlled by affinity thresholds for glycolipid Ags and reveal a novel property of their Ag receptor apparatus that may have an important role in iNKT cell activation.

Published
2003

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